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The mu (µ) and delta (δ) opioid receptors modulate boar sperm motility
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-0256-1958
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-5194-2124
2016 (English)In: Molecular Reproduction and Development, ISSN 1040-452X, E-ISSN 1098-2795Article in journal (Refereed) Epub ahead of print
Abstract [en]

Endogenous and exogenous opioids modulate reproductive functions in target cells via opioid receptors (µ, δ, and κ). Sperm motility is a metric of gamete functionality, and serves as a suitable parameter for in vitro drug-induced toxicity assays. This study identifies the presence and location of opioid receptors in pig spermatozoa as well as their functional response after in vitro challenge with known agonists (morphine [µ]; [D-Pen 2,5]-enkephanile [δ]; and U 50488 [κ]) and antagonists (naloxone [µ]; naltrindole [δ]; and nor-binaltrorphimine [κ]). Only the µ- and δ-opioid receptors were present in the sperm plasma membrane, overlying the acrosome, neck, and principal piece. Challenge experiments with agonists and antagonists identified both µ- and δ-opioid receptors as regulators of sperm kinematics, wherein µ maintains or increases sperm movement whereas δ decreases sperm motility over time. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
John Wiley & Sons, 2016.
Keyword [en]
opioids, membrane receptors, kinematics, pig
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:liu:diva-130181DOI: 10.1002/mrd.22675PubMedID: 27391529OAI: oai:DiVA.org:liu-130181DiVA: diva2:948845
Available from: 2016-07-14 Created: 2016-07-14 Last updated: 2016-08-21Bibliographically approved

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The full text will be freely available from 2017-07-08 18:01
Available from 2017-07-08 18:01

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Vicente Carrillo, AlejandroAlvarez-Rodriguez, ManuelRodriguez-Martinez, Heriberto
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Molecular Reproduction and Development
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