Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation
2016 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 61, 55745-55749 p.Article in journal (Refereed) PublishedText
Extracellular matrix proteins like collagen promote regeneration as implants in clinical studies. However, collagens are large and unwieldy proteins, making small functional peptide analogs potentially ideal substitutes. Self-assembling collagen-like-peptides conjugated with PEG-maleimide were assembled into hydrogels. When tested pre-clinically as corneal implants in mini-pigs, they promoted cell and nerve regeneration, forming neo-corneas structurally and functionally similar to natural corneas.
Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2016. Vol. 6, no 61, 55745-55749 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:liu:diva-130324DOI: 10.1039/c6ra08895cISI: 000378275400008OAI: oai:DiVA.org:liu-130324DiVA: diva2:950295
Funding Agencies|Vinnova Indo-Sweden grant [2013-04645]; Integrative Regenerative Medicine Centre, Linkoping University (LiU); Region Ostergotland; Swedish Research Council grant [621-2012-4286]2016-07-292016-07-282016-08-24