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Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Institute, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, Faculty of Science & Engineering.
FibroGen Inc, CA 94158 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 61, 55745-55749 p.Article in journal (Refereed) PublishedText
Abstract [en]

Extracellular matrix proteins like collagen promote regeneration as implants in clinical studies. However, collagens are large and unwieldy proteins, making small functional peptide analogs potentially ideal substitutes. Self-assembling collagen-like-peptides conjugated with PEG-maleimide were assembled into hydrogels. When tested pre-clinically as corneal implants in mini-pigs, they promoted cell and nerve regeneration, forming neo-corneas structurally and functionally similar to natural corneas.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2016. Vol. 6, no 61, 55745-55749 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-130324DOI: 10.1039/c6ra08895cISI: 000378275400008OAI: oai:DiVA.org:liu-130324DiVA: diva2:950295
Note

Funding Agencies|Vinnova Indo-Sweden grant [2013-04645]; Integrative Regenerative Medicine Centre, Linkoping University (LiU); Region Ostergotland; Swedish Research Council grant [621-2012-4286]

Available from: 2016-07-29 Created: 2016-07-28 Last updated: 2016-08-24

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The full text will be freely available from 2017-06-01 14:34
Available from 2017-06-01 14:34

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Islam, Mohammad MirazulRavichandran, RanjithkumarKozak Ljunggren, MonikaFagerholm, PerLee, Chyan-JangGriffith, MayPhopase, Jaywant
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Division of Cell BiologyFaculty of Medicine and Health SciencesMolecular PhysicsFaculty of Science & EngineeringDivision of Neuro and Inflammation ScienceDepartment of Ophthalmology in LinköpingSensor Science and Molecular PhysicsThe Institute of TechnologyDepartment of Clinical and Experimental Medicine
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