liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
3D Corneal Shape After Implantation of a Biosynthetic Corneal Stromal Substitute
Maisonneuve Rosemt Hospital, Canada; University of Montreal, Canada.
University of Montreal, Canada.
Maisonneuve Rosemt Hospital, Canada.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
Show others and affiliations
2016 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, no 6, 2355-2365 p.Article in journal (Refereed) PublishedText
Abstract [en]

PURPOSE. The current and projected shortage of transplantable human donor corneas has prompted the development of long-term alternatives to human donor tissue for corneal replacement. The biosynthetic stromal substitutes (BSS) characterized herein represent a potentially safe alternative to donor organ transplantation for anterior corneal stromal diseases. The goal of this phase 1 safety study was to characterize the three-dimensional (3D) corneal shape of the first 10 human patients implanted with a BSS and assess its stability over time. METHODS. Ten patients underwent anterior lamellar keratoplasty using a biosynthetic corneal stromal implant for either advanced keratoconus or central corneal scarring. Surgeries were performed at Linkoping University Hospital, between October and November 2007. Serial corneal topographies were performed on all eyes up to a 4-year follow-up when possible. Three-dimensional shape average maps were constructed for the 10 BSS corneas and for 10 healthy controls. Average 3D shape corneal elevation maps, difference maps, and statistics maps were generated. RESULTS. The biosynthetic stromal substitutes implants remained stably integrated into the host corneas over the 4-year follow-up period, without signs of wound dehiscence or implant extrusion. The biosynthetic stromal substitutes corneas showed steeper surface curvatures and were more irregular than the healthy controls. CONCLUSIONS. Corneal astigmatism and surface steepness were observed 4 years after BSS implantation, while the implants remained stably integrated in the host corneas. Future studies will indicate if biomaterials technology will allow for the optimization of postoperative surface irregularity after anterior stromal replacement, a new window of opportunity that is not available with traditional corneal transplantation techniques.

Place, publisher, year, edition, pages
ASSOC RESEARCH VISION OPHTHALMOLOGY INC , 2016. Vol. 57, no 6, 2355-2365 p.
Keyword [en]
corneal implants; artificial cornea; corneal topography; corneal transplantation; keratoconus
National Category
URN: urn:nbn:se:liu:diva-130307DOI: 10.1167/iovs.15-18271ISI: 000378041700001PubMedID: 27136462OAI: diva2:950494

Funding Agencies|Canadian Institutes of Health Research, Canada [MOP 106517]; Stem Cell Network, Ottawa, ON, Canada; FRQS Research in Vision Network, Montreal, QC, Canada; County Council of Ostergotland, Sweden; Charles-Albert Poissant Research Chair in Corneal Transplantation, University of Montreal, Canada

Available from: 2016-07-31 Created: 2016-07-28 Last updated: 2016-08-18

Open Access in DiVA

fulltext(1419 kB)12 downloads
File information
File name FULLTEXT01.pdfFile size 1419 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lagali, NeilFagerholm, PerGriffith, May
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Ophthalmology in LinköpingDivision of Cell Biology
In the same journal
Investigative Ophthalmology and Visual Science

Search outside of DiVA

GoogleGoogle Scholar
Total: 12 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link