liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Post-mortem 1.5T MR quantification of regular anatomical brain structures
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Institute of Forensic Medicine, University of Bern, Switzerland.
Institute of Forensic Medicine, University of Bern, Bern, Switzerland.
Institute of Forensic Medicine, University of Bern, Bern, Switzerland.
Institute of Forensic Medicine, University of Bern, Bern, Switzerland; Department of Diagnostic, Interventional and Pediatric Radiology, University of Bern, Inselspital, Bern, Switzerland.
Show others and affiliations
2016 (English)In: International journal of legal medicine (Print), ISSN 0937-9827, E-ISSN 1437-1596, Vol. 130, no 4, 1071-1080 p.Article in journal (Refereed) PublishedText
Abstract [en]

Recently, post-mortem MR quantification has been introduced to the field of post-mortem magnetic resonance imaging. By usage of a particular MR quantification sequence, T1 and T2 relaxation times and proton density (PD) of tissues and organs can be quantified simultaneously. The aim of the present basic research study was to assess the quantitative T1, T2, and PD values of regular anatomical brain structures for a 1.5T application and to correlate the assessed values with corpse temperatures. In a prospective study, 30 forensic cases were MR-scanned with a quantification sequence prior to autopsy. Body temperature was assessed during MR scans. In synthetically calculated T1, T2, and PD-weighted images, quantitative T1, T2 (both in ms) and PD (in %) values of anatomical structures of cerebrum (Group 1: frontal gray matter, frontal white matter, thalamus, internal capsule, caudate nucleus, putamen, and globus pallidus) and brainstem/cerebellum (Group 2: cerebral crus, substantia nigra, red nucleus, pons, cerebellar hemisphere, and superior cerebellar peduncle) were assessed. The investigated brain structures of cerebrum and brainstem/cerebellum could be characterized and differentiated based on a combination of their quantitative T1, T2, and PD values. MANOVA testing verified significant differences between the investigated anatomical brain structures among each other in Group 1 and Group 2 based on their quantitative values. Temperature dependence was observed mainly for T1 values, which were slightly increasing with rising temperature in the investigated brain structures in both groups. The results provide a base for future computer-aided diagnosis of brain pathologies and lesions in post-mortem magnetic resonance imaging.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 130, no 4, 1071-1080 p.
Keyword [en]
Brain, MR quantification, Post-mortem magnetic resonance imaging (PMMR), Forensic, Neuroimaging
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-130269DOI: 10.1007/s00414-016-1318-3ISI: 000378817900026PubMedID: 26872469OAI: oai:DiVA.org:liu-130269DiVA: diva2:950630
Available from: 2016-08-01 Created: 2016-07-28 Last updated: 2016-08-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Zech, Wolf-DieterPersson, AndersWarntjes, Marcel Jan Bertus
By organisation
Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Division of Cardiovascular MedicineDepartment of Clinical Physiology in Linköping
In the same journal
International journal of legal medicine (Print)
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 45 hits
ReferencesLink to record
Permanent link

Direct link