liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Direct Mechanical Stimulation of Stem Cells: A Beating Electromechanically Active Scaffold for Cardiac Tissue Engineering
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering. Imperial Coll London, England.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Silesian Technical University, Poland.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Pomeranian Medical University, Poland.ORCID iD: 0000-0001-9518-1411
Show others and affiliations
2016 (English)In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 5, no 12, 1471-1480 p.Article in journal (Refereed) PublishedText
Abstract [en]

The combination of stem cell therapy with a supportive scaffold is a promising approach to improving cardiac tissue engineering. Stem cell therapy can be used to repair nonfunctioning heart tissue and achieve myocardial regeneration, and scaffold materials can be utilized in order to successfully deliver and support stem cells in vivo. Current research describes passive scaffold materials; here an electroactive scaffold that provides electrical, mechanical, and topographical cues to induced human pluripotent stem cells (iPS) is presented. The poly(lactic-co-glycolic acid) fiber scaffold coated with conductive polymer polypyrrole (PPy) is capable of delivering direct electrical and mechanical stimulation to the iPS. The electroactive scaffolds demonstrate no cytotoxic effects on the iPS as well as an increased expression of cardiac markers for both stimulated and unstimulated protocols. This study demonstrates the first application of PPy as a supportive electroactive material for iPS and the first development of a fiber scaffold capable of dynamic mechanical actuation.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 5, no 12, 1471-1480 p.
Keyword [en]
actuators; conductive polymers; scaffolds; stem cells; tissue engineering
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-130427DOI: 10.1002/adhm.201600307ISI: 000379550400010PubMedID: 27126086OAI: oai:DiVA.org:liu-130427DiVA: diva2:951182
Note

Funding Agencies|Linkoping University, Integrative Regenerative Medicine (IGEN) Center; Swedish Research Council [VR-2014-3079]; COST-Action [MP1003]; Knut och Alice Wallenberg Commemorative Fund; GeCONiI [POIG.02.03.01-24-099/13]; European Research Agency

Available from: 2016-08-07 Created: 2016-08-05 Last updated: 2016-08-22

Open Access in DiVA

The full text will be freely available from 2017-04-29 15:27
Available from 2017-04-29 15:27

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gelmi, AmyCieslar-Pobuda, Arturde Muinck, EboLos, Marek JanRafat, MehrdadJager, Edwin
By organisation
Department of Physics, Chemistry and BiologyFaculty of Science & EngineeringDivision of Cell BiologyFaculty of Medicine and Health SciencesDivision of Cardiovascular MedicineDepartment of Cardiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Biomedical InstrumentationBiosensors and Bioelectronics
In the same journal
Advanced Healthcare Materials
Biophysics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link