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In situ cardiac perfusion reveals interspecific variation of intraventricular flow separation in reptiles
Department of Zoophysiology, Aarhus University, Aarhus, Denmark.
Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden..
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Department of Zoophysiology, Aarhus University, Aarhus, Denmark..
2016 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 219, no pt 14, 2220-2227 p.Article in journal (Refereed) Published
Abstract [en]

The ventricles of non-crocodilian reptiles are incompletely dividedand provide an opportunity for mixing of oxygen-poor blood andoxygen-rich blood (intracardiac shunting). However, both cardiacmorphology and in vivo shunting patterns exhibit considerableinterspecific variation within reptiles. In the present study, wedevelop an in situ double-perfused heart approach to characterisethe propensity and capacity for shunting in five reptile species: theturtle Trachemys scripta, the rock python Python sebae, the yellowanaconda Eunectes notaeus, the varanid lizard Varanusexanthematicus and the bearded dragon Pogona vitticeps. Tosimulate changes in vascular bed resistance, pulmonary andsystemic afterloads were independently manipulated and changesin blood flow distribution amongst the central outflow tracts weremonitored. As previously demonstrated in Burmese pythons, rockpythons and varanid lizards exhibited pronounced intraventricularflow separation. As pulmonary or systemic afterload was raised, flowin the respective circulation decreased. However, flow in the othercirculation, where afterload was constant, remained stable. Thiscorrelates with the convergent evolution of intraventricular pressureseparation and the large intraventricular muscular ridge, whichcompartmentalises the ventricle, in these species. Conversely, inthe three other species, the pulmonary and systemic flows werestrongly mutually dependent, such that the decrease in pulmonaryflow in response to elevated pulmonary afterload resulted inredistribution of perfusate to the systemic circuit (and vice versa).Thus, in these species, the muscular ridge appeared labile and bloodcould readily transverse the intraventricular cava. We conclude thatrelatively minor structural differences between non-crocodilianreptiles result in the fundamental changes in cardiac function.Further, our study emphasises that functionally similar intracardiacflow separation evolved independently in lizards (varanids) andsnakes (pythons) from an ancestor endowed with the capacity forlarge intracardiac shunts.

Place, publisher, year, edition, pages
The Company of Bologists , 2016. Vol. 219, no pt 14, 2220-2227 p.
Keyword [en]
Cardiovascular, Cardiac shunting, Reptile, Blood flow, Perfused heart
National Category
Physiology
Identifiers
URN: urn:nbn:se:liu:diva-130523DOI: 10.1242/jeb.139543ISI: 000380141000021PubMedID: 27207643OAI: oai:DiVA.org:liu-130523DiVA: diva2:952255
Note

Funding agencies: Danish Research Council (Det Frie Forskningsrad \ Natur og Univers); Swedish Research Council (Vetenskapsradet)

Available from: 2016-08-12 Created: 2016-08-12 Last updated: 2016-08-29

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The full text will be freely available from 2017-05-13 11:23
Available from 2017-05-13 11:23

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