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Teenage girls with type 1 diabetes have poorer metabolic control than boys and face more complications in early adulthood
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Ryhov County Hospital, Sweden.
University of Gothenburg, Sweden.
Copenhagen University Hospital, Denmark.
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2016 (English)In: Journal of diabetes and its complications, ISSN 1056-8727, E-ISSN 1873-460X, Vol. 30, no 5, 917-922 p.Article in journal (Refereed) PublishedText
Abstract [en]

Aims: To compare metabolic control between males and females with type 1 diabetes during adolescence and as young adults, and relate it to microvascular complications. Methods: Data concerning 4000 adolescents with type 1 diabetes registered in the Swedish paediatric diabetes quality registry, and above the age of 18 years in the Swedish National Diabetes Registry was used. Results: When dividing HbA1c values in three groups; amp;lt; 7.4% (57 mmol/mol), 7.4-93% (57-78 mmol/mol) and amp;gt;9.3% (78 mmol/mol), there was a higher proportion of females in the highest group during adolescence. In the group with the highest HbA1c values during adolescence and as adults, 51.7% were females, expected value 46.2%; in the group with low HbA1c values in both registries, 34.2% were females, p amp;lt; 0.001. As adults, more females had retinopathy, p amp;lt; 0.05. Females had higher mean HbAlc values at diagnosis, 112 vs. 10.9% (99 vs. 96 mmol/mol), p amp;lt; 0.03, during adolescence, 8.5 vs. 82% (69 vs. 66 mmol/mol) p amp;lt; 0.01, but not as young adults. Conclusions: Worse glycaemic control was found in adolescent females, and they had a higher frequency of microvascular complications. Improved paediatric diabetes care is of great importance for increasing the likelihood of lower mortality and morbidity later in life. (C) 2016 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2016. Vol. 30, no 5, 917-922 p.
Keyword [en]
HbA1c; Type 1 diabetes; Gender; Microvascular complications; Quality of care
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:liu:diva-130403DOI: 10.1016/j.jdiacomp.2016.02.007ISI: 000378759700028PubMedID: 27052153OAI: diva2:952676

Funding Agencies|Association of Local Authorities and Regions, SALAR; Futurum - Academy for Health and Care, Jonkoping County Council, Sweden

Available from: 2016-08-15 Created: 2016-08-05 Last updated: 2016-09-08

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Samuelsson, UlfHanberger, Lena
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Paediatrics in LinköpingDivision of Nursing Science
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Journal of diabetes and its complications
Endocrinology and Diabetes

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