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Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers
Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.
Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.
Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden/ King's College London, Wolfson Centre for Age Related-Diseases, London, UK / Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
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2016 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 53, no 2, 621-630 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION:

Serotonin (5-HT) is involved in the pathology of Alzheimer's disease (AD).

OBJECTIVE:

We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-β 1-42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms.

METHODS:

15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD).

RESULTS:

Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/Aβ42 ratio (p = 0.001), compared to those with high 5-HT levels.

CONCLUSION:

AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden.

Place, publisher, year, edition, pages
2016. Vol. 53, no 2, 621-630 p.
Keyword [en]
Alzheimer’s disease; amyloid; cognition; platelet; serotonin
National Category
Neurology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:liu:diva-130640DOI: 10.3233/JAD-160022PubMedID: 27163811OAI: oai:DiVA.org:liu-130640DiVA: diva2:953994
Available from: 2016-08-19 Created: 2016-08-19 Last updated: 2016-08-25

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Milovanovic, Micha
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