liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Minimal basilar membrane motion in low-frequency hearing
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Indian Institute Technology, India.
Imperial Coll, England.
Oregon Health and Science University, OR 97239 USA.
Show others and affiliations
2016 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 113, no 30, E4304-E4310 p.Article in journal (Refereed) PublishedText
Abstract [en]

Low-frequency hearing is critically important for speech and music perception, but no mechanical measurements have previously been available from inner ears with intact low-frequency parts. These regions of the cochlea may function in ways different from the extensively studied high-frequency regions, where the sensory outer hair cells produce force that greatly increases the sound-evoked vibrations of the basilar membrane. We used laser interferometry in vitro and optical coherence tomography in vivo to study the low-frequency part of the guinea pig cochlea, and found that sound stimulation caused motion of a minimal portion of the basilar membrane. Outside the region of peak movement, an exponential decline in motion amplitude occurred across the basilar membrane. The moving region had different dependence on stimulus frequency than the vibrations measured near the mechanosensitive stereocilia. This behavior differs substantially from the behavior found in the extensively studied high-frequency regions of the cochlea.

Place, publisher, year, edition, pages
NATL ACAD SCIENCES , 2016. Vol. 113, no 30, E4304-E4310 p.
Keyword [en]
hearing; basilar membrane; optical coherence tomography; hair cells
National Category
URN: urn:nbn:se:liu:diva-130654DOI: 10.1073/pnas.1606317113ISI: 000380346200009PubMedID: 27407145OAI: diva2:954249

Funding Agencies|Swedish Research Council [K2014-63X-14061-14-5]; Torsten Soderberg Foundation; Stiftelsen Tysta Skolan; Strategic Research Area for Systems Neuroscience; NIH National Institute on Deafness and other Communication Disorders [DC 00141, 000105, DC 005983, NS 061800, R01 DC 010399]

Available from: 2016-08-22 Created: 2016-08-19 Last updated: 2016-09-13

Open Access in DiVA

fulltext(1485 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 1485 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Warren, Rebecca L.Fridberger, Anders
By organisation
Department of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDivision of Cell Biology
In the same journal
Proceedings of the National Academy of Sciences of the United States of America

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 37 hits
ReferencesLink to record
Permanent link

Direct link