Klinefelters syndrome (47,XXY) is in excess among men with Sjogrens syndromeCincinnati Childrens Hospital Medical Centre, USA; University of Cincinnati, USA.
Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA; Department Vet Affairs Medical Centre, USA.
Oklahoma Medical Research Fdn, USA.
University of Oklahoma, USA.
University of Oklahoma, USA.
University of Oklahoma, USA; University of Oklahoma, USA.
University of Oklahoma, USA.
University of Oklahoma, USA.
University of Minnesota, USA.
Cedars Sinai Medical Centre, USA.
Cedars Sinai Medical Centre, USA.
Cedars Sinai Medical Centre, USA.
Oklahoma Medical Research Fdn, USA.
Oklahoma Medical Research Fdn, USA; University of Granada, Spain.
Sanat Parque, Argentina.
University of Bergen, Norway; Haukeland Hospital, Norway.
University of Oklahoma, USA.
Strasbourg University, France.
University of Rosario, Colombia.
Kings Coll London, England.
University of Minnesota, USA.
Carolinas Medical Centre, USA.
University of Minnesota, MN USA.
National Institute Dent and Craniofacial Research, MD USA.
University of Paris 11, France.
Mt Sinai Hospital, Canada; University of Toronto, Canada.
Hospital Special Surg, NY USA.
University of Birmingham, England.
University of Toronto, Canada.
Newcastle University, England.
Uppsala University, Sweden.
Örebro University Hospital, Sweden.
Stavanger University Hospital, Norway.
University of Minnesota, USA.
Queen Elizabeth Hospital, Australia; University of Adelaide, Australia.
University of Minnesota, USA.
Karolinska Institute, Sweden.
Hannover Medical Sch, Germany.
University of Paris 11, France.
Oklahoma Medical Research Fdn, USA.
Cincinnati Childrens Hospital Medical Centre, USA; University of Cincinnati, OH USA; Department Vet Affairs Medical Centre, OH USA.
Oklahoma Medical Research Fdn, USA; University of Oklahoma, OK 73190 USA.
Oklahoma Medical Research Fdn, USA; University of Oklahoma, OK 73190 USA; University of Oklahoma, OK 73190 USA; Department Vet Affairs Medical Centre, OK USA.
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2016 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 168, p. 25-29Article in journal (Refereed) Published
Abstract [en]
Primary Sjogrens syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelters syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47)0(Y, p = 0.0012 by Fishers exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fishers exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. Published by Elsevier Inc.
Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2016. Vol. 168, p. 25-29
Keywords [en]
Sjogrens syndrome; X chromosome; Klinefelters syndrome; Sex bias
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-130838DOI: 10.1016/j.clim.2016.04.002ISI: 000380297600004PubMedID: 27109640OAI: oai:DiVA.org:liu-130838DiVA, id: diva2:955820
Note
Funding Agencies|NIH [AR053483, AI082714, AR053734, GM104938]; US Department of Veterans Affairs
2016-08-262016-08-262018-05-18