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Klinefelters syndrome (47,XXY) is in excess among men with Sjogrens syndrome
Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA.
University of Oklahoma,USA; Department Vet Affairs Medical Centre, OK USA.
Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA.
Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA; Department Vet Affairs Medical Centre, OK USA.
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2016 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 168, 25-29 p.Article in journal (Refereed) Published
Abstract [en]

Primary Sjogrens syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelters syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47)0(Y, p = 0.0012 by Fishers exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fishers exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. Published by Elsevier Inc.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2016. Vol. 168, 25-29 p.
Keyword [en]
Sjogrens syndrome; X chromosome; Klinefelters syndrome; Sex bias
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-130838DOI: 10.1016/j.clim.2016.04.002ISI: 000380297600004PubMedID: 27109640OAI: oai:DiVA.org:liu-130838DiVA: diva2:955820
Note

Funding Agencies|NIH [AR053483, AI082714, AR053734, GM104938]; US Department of Veterans Affairs

Available from: 2016-08-26 Created: 2016-08-26 Last updated: 2016-08-26

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Omdal, Roald
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Faculty of Medicine and Health SciencesDivision of Neuro and Inflammation Science
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