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Staphylococcus aureus colonization related to severity of hand eczema
Ryhov County Hospital, Jönköping, Sweden.
Ryhov County Hospital, Jönköping, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Medicine and Health Sciences.
Ryhov County Hospital, Jönköping, Sweden.
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2016 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 35, no 8, 1355-1361 p.Article in journal (Refereed) Published
Abstract [en]

Knowledge on Staphylococcus aureus colonization rates and epidemiology in hand eczema is limited. The aim of this study was to clarify some of these issues. Samples were collected by the "glove juice" method from the hands of 59 patients with chronic hand eczema and 24 healthy individuals. Swab samples were taken from anterior nares and throat from 43 of the 59 patients and all healthy individuals. S. aureus were spa typed and analysed by DNA-microarray-based genotyping. The extent of the eczema was evaluated by the hand eczema extent score (HEES). The colonization rate was higher on the hands of hand eczema patients (69 %) compared to healthy individuals (21 %, p amp;lt; 0.001). This was also seen for bacterial density (p = 0.002). Patients with severe hand eczema (HEES a parts per thousand yen 13) had a significantly higher S. aureus density on their hands compared to those with milder eczema (HEES = 1 to 12, p = 0.004). There was no difference between patients and healthy individuals regarding colonization rates in anterior nares or throat. spa typing and DNA-microarray-based genotyping indicated certain types more prone to colonize eczematous skin. Simultaneous colonization, in one individual, with S. aureus of different types, was identified in 60-85 % of the study subjects. The colonization rate and density indicate a need for effective treatment of eczema and may have an impact on infection control in healthcare.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 35, no 8, 1355-1361 p.
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URN: urn:nbn:se:liu:diva-130833DOI: 10.1007/s10096-016-2672-2ISI: 000380089800017PubMedID: 27193891OAI: diva2:955825

Funding Agencies|Medical Research Council of Southeast Sweden; Futurum - the Academy of Healthcare, County Council, Jonkoping; Medeca Pharma AB, Uppsala

Available from: 2016-08-26 Created: 2016-08-26 Last updated: 2016-09-01

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Henricson, JoakimLindgren, Per-EricAnderson, Chris
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SurgeryFaculty of Medicine and Health SciencesDivision of Microbiology and Molecular MedicineDivision of Neuro and Inflammation ScienceDepartment of Dermatology and Venerology
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European Journal of Clinical Microbiology and Infectious Diseases

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