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Feasibility of MR-based Body Composition Analysis in Large Scale Population Studies
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering.
Nuffield Department of Population Health, University of Oxford.
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 9, e0163332Article in journal (Refereed) Published
Abstract [en]

Introduction

Quantitative and accurate measurements of fat and muscle in the body are important for prevention and diagnosis of diseases related to obesity and muscle degeneration. Manually segmenting muscle and fat compartments in MR body-images is laborious and time-consuming, hindering implementation in large cohorts. In the present study, the feasibility and success-rate of a Dixon-based MR scan followed by an intensity-normalised, non-rigid, multi-atlas based segmentation was investigated in a cohort of 3,000 subjects.

Materials and Methods

3,000 participants in the in-depth phenotyping arm of the UK Biobank imaging study underwent a comprehensive MR examination. All subjects were scanned using a 1.5 T MR-scanner with the dual-echo Dixon Vibe protocol, covering neck to knees. Subjects were scanned with six slabs in supine position, without localizer. Automated body composition analysis was performed using the AMRA Profiler™ system, to segment and quantify visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT) and thigh muscles. Technical quality assurance was performed and a standard set of acceptance/rejection criteria was established. Descriptive statistics were calculated for all volume measurements and quality assurance metrics.

Results

Of the 3,000 subjects, 2,995 (99.83 %) were analysable for fat, 2,828 (94.27 %) were analysable when fat and one thigh was included, and 2,775 (92.50 %) were fully analysable for fat and both thigh muscles. Reasons for not being able to analyse datasets were mainly due to missing slabs in the acquisition, or patient positioned so that large parts of the volume was outside of the field-of-view.

Discussion and Conclusions

In conclusion, this study showed that the rapid UK Biobank MR-protocol was well tolerated by most subjects and sufficiently robust to achieve very high success-rate for body composition analysis. This research has been conducted using the UK Biobank Resource.

Place, publisher, year, edition, pages
Public Library of Science , 2016. Vol. 11, no 9, e0163332
Keyword [en]
Magnetic Resonance, Body Composition Analysis, Population Study, Dixon protocol, Quality Control, Quantitative MRI
National Category
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
Identifiers
URN: urn:nbn:se:liu:diva-131259DOI: 10.1371/journal.pone.0163332OAI: oai:DiVA.org:liu-131259DiVA: diva2:968902
Available from: 2016-09-13 Created: 2016-09-13 Last updated: 2016-09-26Bibliographically approved

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West, JanneDahlqvist Leinhard, OlofRomu, ThobiasBorga, Magnus
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Center for Medical Image Science and Visualization (CMIV)Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Radiological SciencesDepartment of Radiation PhysicsMedical InformaticsFaculty of Science & Engineering
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