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Respiratory Tract Infection and Risk of Hospitalization in Children with Congenital Heart Defects During Season and Off-Season: A Swedish National Study
Umeå University, Sweden; Ostersund Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Sahlgrenska University Hospital, Sweden.
Karolinska University Hospital, Sweden.
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2016 (English)In: Pediatric Cardiology, ISSN 0172-0643, E-ISSN 1432-1971, Vol. 37, no 6, 1098-1105 p.Article in journal (Refereed) Published
Abstract [en]

Respiratory tract infections (RTI) are common among young children, and congenital heart defect (CHD) is a risk factor for severe illness and hospitalization. This study aims to assess the relative risk of hospitalization due to RTI in winter and summer seasons for different types of CHD. All children born in Sweden and under the age of two, in 2006-2011, were included. Heart defects were grouped according to type. Hospitalization rates for respiratory syncytial virus (RSV) infection and RTI in general were retrieved from the national inpatient registry. The relative risk of hospitalization was calculated by comparing each subgroup to other types of CHD and otherwise healthy children. The relative risk of hospitalization was increased for all CHD subgroups, and there was a greater increase in risk in summer for the most severe CHD. This included RSV infection, as well as RTI in general. The risk of hospitalization due to RTI is greater for CHD children. Prophylactic treatment with palivizumab, given to prevent severe RSV illness, is only recommended during winter. We argue that information to healthcare staff and parents should include how the risk of severe infectious respiratory tract illnesses, RSV and others, is present all year round for children with CHD.

Place, publisher, year, edition, pages
SPRINGER , 2016. Vol. 37, no 6, 1098-1105 p.
Keyword [en]
Congenital heart defect (CHD); Immunoprophylaxis; Palivizumab; Respiratory syncytial virus; Respiratory tract infection
National Category
URN: urn:nbn:se:liu:diva-131514DOI: 10.1007/s00246-016-1397-4ISI: 000381279300014PubMedID: 27090653OAI: diva2:974412
Available from: 2016-09-26 Created: 2016-09-23 Last updated: 2016-09-26

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Fernlund, Eva
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Division of Clinical SciencesFaculty of Medicine and Health Sciences
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