Aortic pulse wave velocity predicts incident cardiovascular events in patients with type 2 diabetes treated in primary care
2016 (English)In: Journal of diabetes and its complications, ISSN 1056-8727, E-ISSN 1873-460X, Vol. 30, no 7, 1223-1228 p.Article in journal (Refereed) Published
Aims: The aim was to evaluate the predictive value of aortic pulse wave velocity (aPWV) on incident cardiovascular events in patients with type 2 diabetes without previous cardiovascular disease who were treated in primary care, after adjustment for traditional risk factors. Methods: We measured aPWV in 627 patients who participated in the epidemiological study CARDIPP (Cardiovascular Risk Factors in Patients with Diabetes-a Prospective Study in Primary Care; ClinicalTrials.gov identifier NCT01049737) and who did not have previously known myocardial infarction or stroke. The outcome variable was a composite endpoint consisting of cardiovascular mortality, hospitalization for myocardial infarction and hospitalization for stroke. Results: During a median follow-up time of almost eight years, the unadjusted HR per each increment of aPWV by 1 m/s was 1.239 (95% CI 1.114-1.379, P amp;lt; 0.001) for the primary endpoint. Following adjustments for age, sex, diabetes duration, office systolic blood pressure, resting heart rate, total cholesterol, HbA1c, estimated glomerular filtration rate and smoking status, the adjusted hazard ratio was 1.142 (95% CI 1.003-1.301, P = 0.044). Conclusions: In primary preventive patients with type 2 diabetes treated in primary care, aPWV predicted a composite outcome of incident cardiovascular events independently of diabetes-specific and traditional risk factors. (C) 2016 Elsevier Inc. All rights reserved.
Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2016. Vol. 30, no 7, 1223-1228 p.
Diabetes mellitus; Hypertension; Arterial stiffness; Macrovascular complications; Epidemiology
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:liu:diva-131496DOI: 10.1016/j.jdiacomp.2016.06.008ISI: 000382097600004PubMedID: 27400814OAI: oai:DiVA.org:liu-131496DiVA: diva2:974472
Funding Agencies|FORSS; Research Council of Southeastern Sweden; King Gustaf V and Queen Victoria Freemason Foundation, Sweden2016-09-262016-09-232016-09-26