liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Association of Platelet Serotonin Levels in Alzheimers Disease with Clinical and Cerebrospinal Fluid Markers
Novum, Sweden.
Novum, Sweden.
Novum, Sweden; Kings Coll London, England; University of Khartoum, Sudan.
Karolinska Institute, Sweden.
Show others and affiliations
2016 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 53, no 2, 621-630 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Serotonin (5-HT) is involved in the pathology of Alzheimers disease (AD). Objective: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (A beta(42)), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Methods: 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD). Results: Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/A beta(42) ratio (p = 0.001), compared to those with high 5-HT levels. Conclusion: AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden.

Place, publisher, year, edition, pages
IOS PRESS , 2016. Vol. 53, no 2, 621-630 p.
Keyword [en]
Alzheimers disease; amyloid; cognition; platelet; serotonin
National Category
URN: urn:nbn:se:liu:diva-131591DOI: 10.3233/JAD-160022ISI: 000381207500019PubMedID: 27163811OAI: diva2:974628

Funding Agencies|Konung Gustaf V och Drottning Victorias Stiftelse; Hultmans Stiftelse

Available from: 2016-09-27 Created: 2016-09-27 Last updated: 2016-09-27

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
Journal of Alzheimer's Disease

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 6 hits
ReferencesLink to record
Permanent link

Direct link