liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Rare human nerve growth factor-beta mutation reveals relationship between C-afferent density and acute pain evaluation
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
University of Manchester, England; National Institute Health Research Collaborat Leadership Appl Hlt, England; University of Exeter, England.
Salford Royal Hospital NHS Trust, England; University of Manchester, England; Liverpool John Moores University, England.
Umeå University Hospital, Sweden.
Show others and affiliations
2016 (English)In: Journal of Neurophysiology, ISSN 0022-3077, E-ISSN 1522-1598, Vol. 116, no 2, 425-430 p.Article in journal (Refereed) Published
Abstract [en]

The rare nerve growth factor-beta (NGFB) mutation R221W causes a selective loss of thinly myelinated fibers and especially unmyelinated C-fibers. Carriers of this mutation show altered pain sensation. A subset presents with arthropathic symptoms, with the homozygous most severely affected. The aim of the present study was to investigate the relationship between peripheral afferent loss and pain evaluation by performing a quantification of small-fiber density in the cornea of the carriers, relating density to pain evaluation measures. In vivo corneal confocal microscopy (CCM) was used to quantify C-fiber loss in the cornea of 19 R221W mutation carriers (3 homozygous) and 19 age-matched healthy control subjects. Pain evaluation data via the Situational Pain Questionnaire (SPQ) and the severity of neuropathy based on the Neuropathy Disability Score (NDS) were assessed. Homozygotes, heterozygotes, and control groups differed significantly in corneal C-nerve fiber density, with the homozygotes showing a significant afferent reduction. Importantly, peripheral C-fiber loss correlated negatively with pain evaluation, as revealed by SPQ scores. This study is the first to investigate the contribution of small-fiber density to the perceptual evaluation of pain. It demonstrates that the lower the peripheral small-fiber density, the lower the degree of reported pain intensity, indicating a functional relationship between small-fiber density and higher level pain experience.

Place, publisher, year, edition, pages
AMER PHYSIOLOGICAL SOC , 2016. Vol. 116, no 2, 425-430 p.
Keyword [en]
nerve growth factor-beta gene mutation; corneal confocal microscopy; pain evaluation; Situational Pain Questionnaire; C-fiber
National Category
URN: urn:nbn:se:liu:diva-131581DOI: 10.1152/jn.00667.2015ISI: 000381276400017PubMedID: 27146986OAI: diva2:974659

Funding Agencies|Swedish Research Council Distinguished Young Investigator Award [FF-2013-687]; National Institute for Health Research Wellcome Trust Clinical Research Facility; Heidelberg Engineering UK; Heidelberg Engineering Sweden

Available from: 2016-09-27 Created: 2016-09-27 Last updated: 2016-09-27

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Perini, IreneMorrison, India
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
In the same journal
Journal of Neurophysiology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 7 hits
ReferencesLink to record
Permanent link

Direct link