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  • 1.
    Adolfsson, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Linköping.
    Post-traumatic stiff elbow2018Ingår i: EFORT open reviews, ISSN 2058-5241, Vol. 3, nr 5, s. 210-216Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Post-traumatic and post-operative stiffness of the elbow joint is relatively common and may in pronounced cases markedly interfere with normal upper extremity function.Soft-tissue contractures and heterotopic bone formation are two major causes of limited movement.Extensive recent research has elucidated many of the pathways contributing to these conditions, but the exact mechanisms are still unknown.In the early phase of soft-tissue contractures conservative treatment may be valuable, but in longstanding cases operative treatment is often necessary.Several different options are available depending on the severity of the condition and the underlying offending structures. Surgical treatment may allow significant gains in movement but rarely complete restoration, and complications are not uncommon.The following presentation reviews the recent literature on pathomechanisms and treatment alternatives. Cite this article: EFORT Open Rev 2018;3 DOI: 10.1302/2058-5241.3.170062.

  • 2.
    Ahlström, Christer
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik.
    Liljefeldt, Olle
    Hult, Peter
    Linköpings universitet, Institutionen för medicinsk teknik.
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik.
    Heart sound cancellation from lung sound recordings using recurrence time statistics and nonlinear prediction.2005Ingår i: Medicinteknikdagarna, 2005, Vol. 12, s. 812-815Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    Heart sounds (HS) obscure the interpretation of lung sounds (LS). This letter presents a new method to detect and remove this undesired disturbance. The HS detection algorithm is based on a recurrence time statistic that is sensitive to changes in a reconstructed state space. Signal segments that are found to contain HS are removed, and the arising missing parts are replaced with predicted LS using a nonlinear prediction scheme. The prediction operates in the reconstructed state space and uses an iterated integrated nearest trajectory algorithm. The HS detection algorithm detects HS with an error rate of 4% false positives and 8% false negatives. The spectral difference between the reconstructed LS signal and an LS signal with removed HS was 0 34 0 25, 0 50 0 33, 0 46 0 35, and 0 94 0 64 dB/Hz in the frequency bands 20–40, 40–70, 70–150, and 150–300 Hz, respectively. The cross-correlation index was found to be 99.7%, indicating excellent similarity between actual LS and predicted LS. Listening tests performed by a skilled physician showed high-quality auditory results.

  • 3.
    Alonso Orozco, Fabiola
    Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan.
    Finite Element Method Modelling and Simulations for Comparisonbetween Deep Brain Stimulation Electrodes2012Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The Deep Brain Stimulation (DBS) is an invasive therapy that alleviates the symptoms of several neurological disorders by electrically stimulating specific regions of the brain, generally within the basal ganglia. Until now Medtronic DBS system is the only approved by the Food and Drug Administration, nevertheless European and Australian countries  have recently approved St. Jude DBS systems to treat Parkinson’s disease and related movement disorders.

         Traditionally, voltage-controlled stimulation (the type of systems provided by Medtronic) has been used and clinicians are familiar with its settings; however the knowledge about systems based in current-controlled stimulation (St. Jude systems) is rather scarce. One of the key factors for a successful therapy is the optimal selection of the electrical parameters for stimulation. Due to the critical zone where the surgery is performed, modeling and simulations of DBS systems have been extensively used to observe how the electric field is distributed in the brain tissue and ultimately to help the clinicians to select the best parameters.

         In this thesis two finite element models of the DBS systems mentioned above have been developed; five examinations were designed, based on the physical and electrical differences between the systems, to observe and quantitatively compare the electric field distribution.

        The aim of this thesis was to investigate the differences between two representative models of each company but moreover to contribute with information regarding current-controlled stimulation.

    The results obtained are expected to be useful for further investigations where the magnitude and distribution of the electric field generated by this type of electrodes are needed.

  • 4.
    Andersson, David
    Linköpings universitet, Institutionen för medicinsk teknik.
    Real-time ECG for objective stress level measurement2017Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
  • 5.
    Axelson, Mattias
    Linköpings universitet, Institutionen för medicinsk teknik.
    A Physiological investigation of Rest in Commercial Long-Haul Truck Drivers2018Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
  • 6.
    Bleser, Gabriele
    et al.
    German Research Center for Artificial Intelligence (DFKI), Kaiserslautern, Germany.
    Steffen, Daniel
    German Research Center for Artificial Intelligence (DFKI), Kaiserslautern, Germany.
    Weber, Markus
    German Research Center for Artificial Intelligence (DFKI), Kaiserslautern, Germany.
    Hendeby, Gustaf
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för systemteknik, Reglerteknik.
    Stricker, Didier
    German Research Center for Artificial Intelligence (DFKI), Kaiserslautern, Germany.
    Fradet, Laetitia
    Université de Technologie de Compiègne, France.
    Marin, Frédéric
    Université de Technologie de Compiègne, France.
    Ville, Nathalie
    CIC-IT Inserm 804, Rennes, France.
    Carré, Francois
    CIC-IT Inserm 804, Rennes, France.
    A personalized exercise trainer for the elderly2013Ingår i: Journal of Ambient Intelligence and Smart Environments, ISSN 1876-1364, E-ISSN 1876-1372, Vol. 5, nr 6, s. 547-562Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Regular and moderate physical activity practice provides many physiological benefits. It reduces the risk of disease outcomes and is the basis for proper rehabilitation after a severe disease. Aerobic activity and strength exercises are strongly recommended in order to maintain autonomy with ageing. Balanced activity of both types is important, especially to the elderly population. Several methods have been proposed to monitor aerobic activities. However, no appropriate method is available for controlling more complex parameters of strength exercises. Within this context, the present article introduces a personalized, home-based strength exercise trainer designed for the elderly. The system guides a user at home through a personalized exercise program. Using a network of wearable sensors the user's motions are captured. These are evaluated by comparing them to prescribed exercises, taking both exercise load and technique into account. Moreover, the evaluation results are immediately translated into appropriate feedback to the user in order to assist the correct exercise execution. Besides the direct feedback, a major novelty of the system is its generic personalization by means of a supervised teach-in phase, where the program is performed once under supervision of a physical activity specialist. This teach-in phase allows the system to record and learn the correct execution of exercises for the individual user and to provide personalized monitoring. The user-driven design process, the system development and its underlying activity monitoring methodology are described. Moreover, technical evaluation results as well as results concerning the usability of the system for ageing people are presented. The latter has been assessed in a clinical study with thirty participants of 60 years or older, some of them showing usual diseases or functional limitations observed in elderly population.

  • 7.
    Fredriksson, Ingemar
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan. Perimed AB, Järfälla, Sweden.
    Burdakov, Oleg
    Linköpings universitet, Matematiska institutionen, Optimeringslära. Linköpings universitet, Tekniska högskolan.
    Larsson, Marcus
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Strömberg, Tomas
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Inverse Monte Carlo in a multilayered tissue model: merging diffuse reflectance spectroscopy and laser Doppler flowmetry2013Ingår i: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 18, nr 12, s. 127004-1-127004-14Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The tissue fraction of red blood cells (RBCs) and their oxygenation and speed-resolved perfusion areestimated in absolute units by combining diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry(LDF). The DRS spectra (450 to 850 nm) are assessed at two source–detector separations (0.4 and 1.2 mm), allowingfor a relative calibration routine, whereas LDF spectra are assessed at 1.2mmin the same fiber-optic probe. Data areanalyzed using nonlinear optimization in an inverse Monte Carlo technique by applying an adaptive multilayeredtissue model based on geometrical, scattering, and absorbing properties, as well as RBC flow-speed information.Simulations of 250 tissue-like models including up to 2000 individual blood vessels were used to evaluatethe method. The absolute root mean square (RMS) deviation between estimated and true oxygenation was 4.1percentage units, whereas the relative RMS deviations for the RBC tissue fraction and perfusion were 19% and23%, respectively. Examples of in vivo measurements on forearm and foot during common provocations arepresented. The method offers several advantages such as simultaneous quantification of RBC tissue fractionand oxygenation and perfusion from the same, predictable, sampling volume. The perfusion estimate is speedresolved, absolute (% RBC × mm∕s), and more accurate due to the combination with DRS.

  • 8.
    Fredriksson, Ingemar
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Larsson, Marcus
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Strömberg, Tomas
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Model-Based Quantification of Skin Microcirculatory Perfusion2014Ingår i: Computational Biophysics of the Skin / [ed] Bernard Querleux, Singapore: Pan Stanford Publishing, 2014, 1, s. 395-420Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 9.
    Latorre, Malcolm
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten.
    Salerud, Göran
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten.
    Wårdell, Karin
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten.
    Describing Measurement Behaviour of a Surface Ag-AgCl Electrode Using the Paxon Test Platform2016Ingår i: XIV MEDITERRANEAN CONFERENCE ON MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING 2016, SPRINGER , 2016, Vol. 57, s. 442-445Konferensbidrag (Refereegranskat)
    Abstract [en]

    A better understanding of bioelectrodes can be acquired with extended testing, which will lead to better methodology and data quality. Today electrodes are evaluated for intraelectrode differences and performance with a traditional gain-phase method, while using the physical axon action potential generator (Paxon) test platform offers extended test possibilities. The direct gain-phase measurements are useful to extract the transfer function of the electrode, as well as some other base parameters. The Paxon test platform is a complementary method that tests electrodes under conditions that are more realistic, mimicking real measurement situations in comparison to the gain-phase method. The Paxon also allows tests to be performed beyond what the gain-phase methods can measure, for example electrode rotation, which would uncover variations in the symmetry of the electrode. When tested, the symmetry properties of the electrode, where the electrodes are rotated in steps of 90 degrees, resulted in a peak to peak variation in detected amplitude of 5.3 +/- 8.9 mV. Therefore, the Paxon appears to be a feasible test platform for characterizing electrodes beyond the gain-phase tests in a semiautomatic manner.

  • 10.
    Parlak, Onur
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska fakulteten.
    Tiwari, Ashutosh
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska högskolan.
    Turner, Anthony
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska fakulteten.
    Switchable bioelectronics on graphene interface.2015Ingår i: Biosensing and Nanomedicine-VIII at SPIE Optics and Photonics, San Diego, CA, 9-13 August 2015., 2015Konferensbidrag (Refereegranskat)
    Abstract [en]

    Smart and flexible bioelectronics on graphene have emerged as a new frontier in the field of biosensors and bioelectronics. Graphene has begun to be seen as an ideal signal transducer and a promising alternative for the production of low-cost bioelectronic devices.1-2 However, biological systems used in these devices suffer from a lack of control and regulation. There is an obvious need to develop “switchable” and “smart” interfaces for both fundamental and applied studies. Here, we report the fabrication of a stimuli-responsive graphene interface, which is used to regulate biomolecular reactions.

    The present study aims to address the design and development of a novel auto-switchable graphene bio-interface that is capable of positively responding, by creating smart nanoarchitectures. The smart bio-interface consists of a two-dimensional graphene donor and a polymeric receptor, which are rationally assembled together based in a stoichiometric donor-receptor interaction. By changing the external conditions such as temperature, light and pH of the medium, we acheived control of the biochemical interactions. In the negative mode, access of an associated enzyme to its substrate is largely restricted, resulting in a decrease in the diffusion of reactants and the consequent activity of the system. In contrast, the biosubstrate could freely access the enzyme facilitating bioelectrocatalysis in a positive response. More importantly, this provides the first example of responsive bioelectronics being achieved on a two-dimensional graphene interface by controlling the various external stimuli in an on/off-switchable model.

    Using electrochemical techniques, we demonstrated that interfacial bio-electrochemical properties can be tuned by modest changes in conditions. Such an ability to independently regulate the behaviour of the interface has important implications for the design of novel bioreactors, biofuel cells and biosensors with inbuilt self-control features.

    Reference:

    [1] O. Parlak, A. P. F. Turner, A. Tiwari, Advanced Materials, 3 (2014), 482.

    [2] O. Parlak, A. Tiwari, A. P. F. Turner, A. Tiwari, Biosensors and Bioelectronics 49         (2013), 53.

  • 11.
    Rowa, Per
    et al.
    Linköpings universitet, Institutionen för systemteknik. Linköpings universitet, Tekniska högskolan.
    Antonsson, Dan
    Linköpings universitet, Institutionen för systemteknik. Linköpings universitet, Tekniska högskolan.
    Automated Malaria Parasite Detection1977Rapport (Övrigt vetenskapligt)
    Abstract [en]

    A system for malaria parasite detection in thin blood-smears is presented. Sample slides prepared with standard methods are accepted. A low-cost TV-camera mounted on an ordinary microscope with a computer controlled stage is used as a picture sensor. Frames, digitized in windows of 64 x 64 pixels are fed into a special purpose picture processor at normal frame rate (25 frames/sec). In the picture processor measurements are made on the images at high speed. The classification problem is split into different levels each having different characteristics such as different sampling density. Four classes, three of which are different types of malaria parasites, are recognized. As a whole the classification is best labelled as a sequential pattern recognition procedure.

    In its preliminary version the system has been run at a speed comparable to that of a human operator, that is l 500 cells per minute. A test on 80 000 cells gave 25 false negatives out of 283 parasites (9%) and 41 false positives (0.05%).

  • 12.
    Sedghamiz, Hooman
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik.
    AN ALGORITHM TO PREDICT THEFILAMENT AGING IN C/V MRC TUBES2013Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
  • 13.
    Shamsudin, Nebil
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    A Device for Measurement of Capillary Refilling Time2012Självständigt arbete på avancerad nivå (masterexamen), 80 poäng / 120 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The main objective of this project is to design, construct and validate a portable prototype of a device that is capable of performing a test to accurately measure Capillary Refilling Time (CRT), and to analyze the results with defined parameters; force, area, pressure (compression) and time. This prototype is dedicated to study and evaluate CRT readouts for different pressure values, collected from healthy subjects.The presented prototype of this study is capable of producing skin compressing and to measure the refilling time of capillaries following this compression. This prototype introduces accuracy, mechanical reproducibility and controlling options for the applied pressure and compression time. The presented prototype is non-invasive, portable and it can be used to conduct more CRT tests and other capillary refilling studies.CRT measurement is done by calculating time interval starting from the first point when the applied pressure is released; ending with the recording point at the time when the concentration of red blood cells has reached the level of its pre-occlusion values.Based on the calculated CRT values and the number of iterations of the test in CRT tables, one can observe that given the same applied pressure value, CRT values do not significantly vary when the test is repetitively conducted on the same subject and on the same site.

  • 14.
    Sridharan, Kousik Sarathy
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Real-time acquisition and analysis ofElectro-oculography signals2012Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Electro-oculography signals are corneo-retinal potentials that carry informationpertaining to eye movements. This information can be used to estimate drowsinesslevel of the subject which could provide interesting insights into research of acci-dent prevention. Of all features present, blink duration has been proved to be aneffective measure of drowsiness. The aim of this thesis work is to build a portablesystem to acquire and analyze electro-oculographic (EOG) signals in real-time.The system contains two sub-systems; a hardware sub-system that consists of thefilters, amplifiers, data acquisition card and isolation and the software sub-systemthat contains the program to acquire and analyze the signal and present the resultsto the observer. The filters were designed starting with simulation, implementa-tion on the prototype board, culminating in the design of a printed circuit board(PCB) and packaging. The complete software was written in PythonTMusing sev-eral relevant libraries for data processing. A text-based user interface was createdto enable easy user interaction. The results are graphically displayed in real-time.

    Ex-situ tests were done with two volunteers while in-situ test was done onone subject. The data from the in-situ tests showed "good signal quality" in a"noisy" environment concurring with the design specifications. To motivate theimportance of calibration, two calibration paradigms were used during ex-situtests, where one paradigm records only normal blinks while the other records longblinks and the results showed differences in detection and error rates. The obser-vations made from performance tests at various levels gave "satisfactory results"and proved the usefulness of the system for experimental purposes in-situ.

1 - 14 av 14
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