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  • 1.
    Ahlström, Christer
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Hälsouniversitetet.
    Höglund, Katja
    Hult, Peter
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Hälsouniversitetet.
    Häggström, Jens
    Kvart, Clarence
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Hälsouniversitetet.
    Assessing Aortic Stenosis using Sample Entropy of the Phonocardiographic Signal in Dogs2008Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 55, nr 8, s. 2107-2109Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In aortic valve stenosis (AS), heart murmurs arise as an effect of turbulent blood flow distal to the obstructed valves. With increasing AS severity, the flow becomes more unstable, and the ensuing murmur becomes more complex. We hypothesize that these hemodynamic flow changes can be quantified based on the complexity of the phonocardiographic (PCG) signal. In this study, sample entropy (SampEn) was investigated as a measure of complexity using a dog model. Twenty-seven boxer dogs with various degrees of AS were examined with Doppler echocardiography, and the peak aortic flow velocity (Vmax) was used as a reference of AS severity. SampEn correlated to Vmax with R = 0.70 using logarithmic regression. In a separate analysis, significant differences were found between physiologic murmurs and murmurs caused by AS (p < 0.05), and the area under a receiver operating characteristic curve was calculated to 0.96. Comparison with previously presented PCG measures for AS assessment showed improved performance when using SampEn, especially for differentiation between physiological murmurs and murmurs caused by mild AS. Studies in patients will be needed to properly assess the technique in humans.

  • 2.
    Asplund, Maria
    et al.
    Neuronic Engineering, School of Technology and Health, Royal Institute of Technology, Alfred Nobels Allé 10, 146 57 Huddinge, Stockholm, Sweden.
    Hamedi, Mahiar
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska högskolan.
    Forchheimer, Robert
    Linköpings universitet, Institutionen för systemteknik, Bildkodning. Linköpings universitet, Tekniska högskolan.
    Inganäs, Olle
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska högskolan.
    Holst, Hans von
    Neuronic Engineering, School of Technology and Health, Royal Institute of Technology, Alfred Nobels Allé 10, 146 57 Huddinge, Stockholm, Sweden/Division of Clinical Neuroscience, Section Neurosurgery, Karolinska Institutet, Stockholm, Sweden.
    Construction of wire electrodesand 3D woven logicas a potential technology forneuroprosthetic implants2008Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    New strategies to improve neuron coupling to neuroelectronic implants are needed. In particular, tomaintain functional coupling between implant and neurons, foreign body response like encapsulation must meminimized. Apart from modifying materials to mitigate encapsulation it has been shown that with extremely thinstructures, encapsulation will be less pronounced. We here utilize wire electrochemical transistors (WECTs) usingconducting polymer coated fibers. Monofilaments down to 10 μm can be successfully coated and weaved intocomplex networks with built in logic functions, so called textile logic. Such systems can control signal patterns at alarge number of electrode terminals from a few addressing fibres. Not only is fibre size in the range where lessencapsulation is expected but textiles are known to make successful implants because of their soft and flexiblemechanical properties. Further, textile fabrication provides versatility and even three dimensional networks arepossible. Three possible architectures for neuroelectronic systems are discussed. WECTs are sensitive to dehydrationand materials for better durability or improved encapsulation is needed for stable performance in biologicalenvironments.

  • 3.
    Karlsson, A.
    et al.
    Department of Electroscience, Lund University, Lund 221 00, Sweden, Chalmers University of Technology, Gothenburg, Sweden.
    He, J.
    Department of Electroscience, Lund University, Lund 221 00, Sweden, Zhejiang Normal University, Department of Optical Engineering, Zhejiang University, Department of Physics, Linkoping University, Linkoping, Sweden.
    Swartling, J.
    Department of Physics, Lund University, Lund 221 00, Sweden, Lund Institute of Technology, Lund, Sweden, Department of Physics, Politecnico di Milano, Milan, Italy.
    Andersson-Engels, S.
    Department of Physics, Lund University, Lund 221 00, Sweden, Atom. Phys. Div. at Lund University, Lund, Sweden.
    Numerical simulations of light scattering by red blood cells2005Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 52, nr 1, s. 13-18Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Scattering of electromagnetic waves from a red blood cell is simulated using the finite-difference time-domain method (FDTD), the Rytov approximation and the discrete dipole approximation (DDA). Both FDTD and DDA are fall wave methods that give accurate results in a wide range of wavelengths. The Rytov approximation is a much simpler method that is limited to scattering angles within 30° from the forward direction. The investigation comprehends different wavelengths and different orientations of the cell. It shows that the shape, volume, and orientation of the cell have a large inflaence on the forward scattering.

  • 4.
    Karlsson, S.
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Rehabiliteringsmedicin.
    Yu, J
    Akay, M
    Time-frequency analysis of myoelectric signals during dynamic contractions: A comparative study2000Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 47, nr 2, s. 228-238Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this paper, we introduce the nonstationary signal analysis methods to analyze the myoelectric (ME) signals during dynamic contractions by estimating the time-dependent spectral moments. The time-frequency analysis methods including the short-time Fourier transform, the Wigner-Ville distribution, the Choi-Williams distribution, and the continuous wavelet transform were compared for estimation accuracy and precision on synthesized and real ME signals. It is found that the estimates provided by the continuous wavelet transform have better accuracy and precision than those obtained with the other time-frequency analysis methods on simulated data sets. In addition, ME signals from four subjects during three different tests (maximum static voluntary contraction, ramp contraction, and repeated isokinetic contractions) were also examined.In this paper, we introduce the nonstationary signal analysis methods to analyze the myoelectric (ME) signals during dynamic contractions by estimating the time-dependent spectral moments. The time-frequency analysis methods including the short-time Fourier transform, the Wigner-Ville distribution, the Choi-Williams distribution, and the continuous wavelet transform were compared for estimation accuracy and precision on synthesized and real ME signals. It is found that the estimates provided by the continuous wavelet transform have better accuracy and precision than those obtained with the other time-frequency analysis methods on simulated data sets. In addition, ME signals from four subjects during three different tests (maximum static voluntary contraction, ramp contraction, and repeated isokinetic contractions) were also examined.

  • 5. Karlsson, Stefan
    et al.
    Yu, Jun
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Rehabiliteringsmedicin.
    Enhancement of spectral analysis of myoelectric signals during static concentrations using wavelet methods.1999Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 46, s. 670-684Artikel i tidskrift (Refereegranskat)
  • 6.
    Knutsson, Hans E.
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Edholm, Paul
    n/a.
    Granlund, Gösta H.
    Linköpings universitet, Institutionen för systemteknik, Bildbehandling. Linköpings universitet, Tekniska högskolan.
    Petersson, Christer U.
    n/a.
    Ectomography. A New Radiographic Reconstruction Method: I. Theory and Error Estimates1980Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. BME--27, nr 11, s. 640-645Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Radiographic technology has advanced considerably during the last years with the advent of reconstruction techniques allowing visualization of slices through the body. In spite of the advantage of computed tomography compared to conventional radiographic methods, there are still some shortcomings with the method If a different section of the body is desired, another recording has to be made, the width of the dice reconstructed is fixed, and a full 1800 view angle is required.

  • 7.
    Kukreja, S.L.
    et al.
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska högskolan.
    Galiana, H.L.
    Dept. of Biomedical Engineering, McGill University, Montreal, QC H3A 2T5, Canada.
    Kearney, R.E.
    Dept. of Biomedical Engineering, McGill University, Montreal, QC H3A 2T5, Canada.
    NARMAX representation and identification of ankle dynamics2003Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 50, nr 1, s. 70-81Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Representation and identification of a parallel pathway description of ankle dynamics as a model of the nonlinear autoregressive, moving average exogenous (NARMAX) class is considered. A nonlinear difference equation describing this ankle model is derived theoretically and shown to be of the NARMAX form. Identification methods for NARMAX models are applied to ankle dynamics and its properties investigated via continuous-time simulations of experimental conditions. Simulation results show that 1) the outputs of the NARMAX model match closely those generated using continuous-time methods and 2) NARMAX identification methods applied to ankle dynamics provide accurate discrete-time parameter estimates. Application of NARMAX identification to experimental human ankle data models with high cross-validation variance accounted for.

  • 8.
    Petersson, Christer U.
    et al.
    n/a.
    Edholm, Paul
    n/a.
    Granlund, Gösta H.
    Linköpings universitet, Institutionen för systemteknik, Bildbehandling. Linköpings universitet, Tekniska högskolan.
    Knutsson, Hans E.
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Ectomography. A New Radiographic Reconstruction Method: II. Computer Simulated Experiments1980Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. BME--27, nr 11, s. 649-655Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In a special radiographic process, ectomography, an image of a slice is produced by simple summation of a set of specially filtered component images, of which each represents one of at least 60 different projections of the object. After being digitized, they are stored, filtered, and summed in a computer. Images representing any slice of any thickness in the object may be produced from the same set of component images. All details within the slice are pictured correctly while details outside are almost completely eliminated.

  • 9.
    Pettersson, Johanna
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Palmerius, Karljohan
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Knutsson, Hans
    Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Wahlström, Ola
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
    Tillander, Bo
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
    Borga, Magnus
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Simulation of Patient Specific Cervical Hip Fracture Surgery With a Volume Haptic Interface2008Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 55, nr 4, s. 1255-1265Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The interest for surgery simulator systems with anatomical models generated from authentic patient data is growing as these systems evolve.With access to volumetric patient data, e.g., from a computer tomography scan, haptic and visual feedback can be created directly from this dataset. This opens the door for patient specific simulations. Hip fracture surgery is one area where simulator systems is useful to train new surgeons and plan operations. To simulate the drilling procedure in this type of surgery, a repositioning of the fractured bone into correct position is first needed. This requires a segmentation process in which the bone segments are identified and the position of the dislocated part is determined. The segmentation must be automatic to cope with the large amount of data from the computer tomography scan. This work presents the first steps in the development of a hip fracture surgery simulation with patient specific models. Visual and haptic feedback is generated from the computer tomography data by simulating fluoroscopic images and the drilling process. We also present an automatic segmentation method to identify the fractured bone and determine the dislocation. This segmentation method is based on nonrigid registration with the Morphon method.

  • 10.
    Pham, Tuan
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Yan, Hong
    City University of Hong Kong, Hong Kong.
    Tensor Decomposition of Gait Dynamics in Parkinson's Disease2018Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 65, nr 8, s. 1820-1827Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: The study of gait in Parkinson's disease is important because it can provide insights into the complex neural system and physiological behaviors of the disease, of which understanding can help improve treatment and lead to effective developments of alternative neural rehabilitation programs. This paper aims to introduce an effective computational method for multi-channel or multi-sensor data analysis of gait dynamics in Parkinson's disease.

    Method: A model of tensor decomposition, which is a generalization of matrix-based analysis for higher dimensional analysis, is designed for differentiating multi-sensor time series of gait force between Parkinson's disease and healthy control cohorts.

    Results: Experimental results obtained from the tensor decomposition model using a PhysioNet database show several discriminating characteristics of the two cohorts, and the achievement of 100% sensitivity and 100% specificity under various cross-validations.

    Conclusion: Tensor decomposition is a useful method for the modeling and analysis of multi-sensor time series in patients with Parkinson's disease.

    Significance: Tensor-decomposition factors can be potentially used as physiological markers for Parkinson's disease, and effective features for machine learning that can provide early prediction of the disease progression.

  • 11.
    Prateek, G. V
    et al.
    Washington Univ St Louis, MO 63130 USA.
    Skog, Isaac
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    McNeely, Marie E.
    Washington Univ, MO 63130 USA.
    Duncan, Ryan P.
    Washington Univ, MO 63130 USA.
    Earhart, Gammon M.
    Washington Univ, MO 63130 USA.
    Nehorai, Arye
    Washington Univ St Louis, MO 63130 USA.
    Modeling, Detecting, and Tracking Freezing of Gait in Parkinson Disease Using Inertial Sensors2018Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 65, nr 10, s. 2152-2161Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this paper. we develop new methods to automatically detect the onset and duration of freezing of gait (FOG) in people with Parkinson disease (PD) in real time, using inertial sensors. We first build a physical model that describes the trembling motion during the FOG events. Then, we design a generalized likelihood ratio test framework to develop a two-stage detector for determining the zero-velocity and trembling events during gait. Thereafter, to filter out falsely detected FOG events, we develop a point-process filter that combines the output of the detectors with information about the speed of the foot, provided by a foot-mounted inertial navigation system. We computed the probability of FOG by using the point-process filter to determine the onset and duration of the FOG event. Finally, we validate the performance of the proposed system design using real data obtained from people with PD who performed a set of gait tasks. We compare our FOG detection results with an existing method that only uses accelerometer data. The results indicate that our method yields 81.03% accuracy in detecting FOG events and a threefold decrease in the false-alarm rate relative to the existing method.

  • 12. Storck, K
    et al.
    Karlsson, Matts
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk modellering och simulering.
    Ask, Per
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik.
    Loyd, Dan
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för konstruktions- och produktionsteknik, Mekanisk värmeteori och strömningslära.
    Heat transfer simulation in the evaluation of the nasal thermistor technique1996Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 43, s. 1187-1191Artikel i tidskrift (Refereegranskat)
  • 13.
    Wårdell, Karin
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Jakobsson, A.
    Nilsson, Gert
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Laser Doppler Perfusion Imaging by Dynamic Light Scattering1993Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 40, nr 4, s. 309-316Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A laser Doppler perfusion imaging technique based on dynamic light scattering in tissue is reported. When a laser beam sequentially scans the tissue (maximal area approximately 12 cm*12 cm), moving blood cells generate Doppler components in the backscattered light. A fraction of this light is detected by a remote photodiode and converted into an electrical signal. In the signal processor, a signal proportional to the tissue perfusion at each measurement point is calculated and stored. When the scanning procedure is completed, the system generates a color-coded perfusion image on a monitor. A perfusion image is typically built up of data from 4096 measurement sites, recorded during a time period of 4 min. This image has a spatial resolution of about 2 mm. A theory for the system inherent amplification factor dependence on the distance between individual measurement points and detector is proposed and correction measures are presented. Performance results for the laser Doppler perfusion imager obtained with a flow simulator are presented. The advantages of the method are discussed.

  • 14. Zhong, J
    et al.
    Nilsson, Gert
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik.
    Salerud, Göran
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik.
    A Note on The Compartmental Analysis and Other Related Problems in Laser Doppler Flowmetry1998Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 45, nr 4, s. 534-537Artikel i tidskrift (Refereegranskat)
    Abstract [en]

        

  • 15. Zhong, J
    et al.
    Seifalian, A
    Salerud, Göran
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik.
    Nilsson, Gert
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik.
    A mathematical Analysis on The Biological Zero Problem in Laser Doppler Flowmetry1998Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 45, nr 3, s. 354-364Artikel i tidskrift (Refereegranskat)
    Abstract [en]

       

  • 16.
    Åström, Mattias
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan. Sapiens Steering Brain Stimulation BV, NL-5656 Eindhoven, Netherlands.
    Diczfalusy, Elin
    Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan.
    Martens, Hubert
    Sapiens Steering Brain Stimulation B.V., Eindhoven, The Netherlands.
    Wårdell, Karin
    Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan.
    Relationship between Neural Activation and Electric Field Distribution during Deep Brain Stimulation2015Ingår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 62, nr 2, s. 664-72Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Models and simulations are commonly used to study deep brain stimulation (DBS). Simulated stimulation fields are often defined and visualized by electric field isolevels or volumes of tissue activated (VTA). The aim of the present study was to evaluate the relationship between stimulation field strength as defined by the electric potential V, the electric field E, and the divergence of the electric field ∇(2) V, and neural activation. Axon cable models were developed and coupled to finite-element DBS models in three-dimensional (3-D). Field thresholds ( VT , ET, and ∇(2) VT ) were derived at the location of activation for various stimulation amplitudes (1 to 5 V), pulse widths (30 to 120 μs), and axon diameters (2.0 to 7.5 μm). Results showed that thresholds for VT and ∇(2) VT were highly dependent on the stimulation amplitude while ET were approximately independent of the amplitude for large axons. The activation field strength thresholds presented in this study may be used in future studies to approximate the VTA during model-based investigations of DBS without the need of computational axon models.

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