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  • 1.
    Ahnesjö, Anders
    et al.
    Uppsala University, Sweden.
    van Veelen, Bob
    Elekta Brachytherapy, Netherlands.
    Carlsson Tedgren, Åsa
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US. Karolinska University Hospital, Sweden.
    Collapsed cone dose calculations for heterogeneous tissues in brachytherapy using primary and scatter separation source data2017Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 139, s. 17-29Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background and Objective: Brachytherapy is a form of radiation therapy using sealed radiation sources inserted within or in the vicinity of the tumor of, e.g., gynecological, prostate or head and neck cancers. Accurate dose calculation is a crucial part of the treatment planning. Several reviews have called for clinical software with model-based algorithms that better take into account the effects of patient individual distribution of tissues, source-channel and shielding attenuation than the commonly employed TG-43 formalism which simply map homogeneous water dose distributions onto the patient. In this paper we give a comprehensive and thorough derivation of such an algorithm based on collapsed cone point-kernel superposition, and describe details of its implementation into a commercial treatment planning system for clinical use. Methods: A brachytherapy version of the collapsed-cone algorithm using analytical raytraces of the primary photon radiation followed by successive scattering dose calculation for once and multiply scattered photons is described in detail, including derivation of the corresponding set of recursive equations for energy transport along cone axes/transport lines and the coupling to clinical source modeling. Specific implementation issues for setting up of the calculation grid, handling of intravoxel gradients and voxels partly containing non patient applicator material are given. Results: Sample runs for two clinical cases are shown, one being a gynecological application with a tungsten-shielded applicator and one a breast implant. These two cases demonstrate the impact of improved dose calculation versus TG-43 formalism. Conclusions: Use of model-based dose calculation algorithms for brachytherapy taking the three-dimensional treatment geometry into account increases the dosimetric accuracy in planning and follow up of treatments. The comprehensive description and derivations provided gives a rigid background for further clinical, educational and research applications. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

  • 2.
    Bauwens, Maite
    et al.
    Vrije Universiteit Brussel, Belgium.
    Ohlsson, Henrik
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska högskolan.
    Barbé, Kurt
    Vrije Universiteit Brussel, Belgium.
    Beelaerts, Veerle
    Vrije Universiteit Brussel, Belgium.
    Dehairs, Frank
    Vrije Universiteit Brussel, Belgium.
    Schoukens, Johan
    Vrije Universiteit Brussel, Belgium.
    On Climate Reconstruction Using Bivalve Shells: Three Methods To Interpret the Chemical Signature of a Shell2011Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 104, nr 2, s. 104-111Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    To improve our understanding of the climate process and to assess the human impact on current global warming, past climate reconstruction is essential. The chemical composition of a bivalve shell is strongly coupled to environmental variations and therefore ancient shells are potential climate archives. The nonlinear nature of the relation between environmental condition (e.g. the seawater temperature) and proxy composition makes it hard to predict the former from the latter, however. In this paper we compare the ability of three nonlinear system identification methods to reconstruct the ambient temperature from the chemical composition of a shell. The comparison shows that nonlinear multi-proxy approaches are potentially useful tools for climate reconstructions and that manifold based methods result in smoother and more precise temperature reconstruction.

  • 3. Edvardsson, Hannes
    et al.
    Smedby, Örjan
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Radiologi. Östergötlands Läns Landsting, Bildmedicinskt centrum, Avdelningen för radiologi US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Compact and efficient 3D shape description through radial function approximation2003Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 72, nr 2, s. 89-97Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A fast and simple method for three-dimensional shape description is described. The method views a 3D object as a radial distance function on the unit sphere, and thus reduces the dimensionality of the description problem by one. The radial distance function is approximated by Fourier methods in the basis of the spherical harmonic polynomials. The necessary integration is carried out on the object boundary, rather than on the unit sphere. Consequently, there is no need of a parameterisation of the object surface. The description makes it possible to compare shapes in a computationally very simple way. Solutions on how to cope with translated and rotated objects are discussed. The method is developed for star-shaped objects, but is stable even if the input image is non-star-shaped. The method is tested in a data set from magnetic resonance imaging (MRI) of the brain. Potential medical applications are discussed. ⌐ 2002 Elsevier Science Ireland Ltd. All rights reserved.

  • 4.
    Eklund, Anders
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Andersson, Mats
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Knutsson, Hans
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    fMRI Analysis on the GPU - Possibilities and Challenges2012Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 105, nr 2, s. 145-161Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Functional magnetic resonance imaging (fMRI) makes it possible to non-invasively measure brain activity with high spatial resolution.There are however a number of issues that have to be addressed. One is the large amount of spatio-temporal data that needsto be processed. In addition to the statistical analysis itself, several preprocessing steps, such as slice timing correction and motioncompensation, are normally applied. The high computational power of modern graphic cards has already successfully been used forMRI and fMRI. Going beyond the first published demonstration of GPU-based analysis of fMRI data, all the preprocessing stepsand two statistical approaches, the general linear model (GLM) and canonical correlation analysis (CCA), have been implementedon a GPU. For an fMRI dataset of typical size (80 volumes with 64 x 64 x 22 voxels), all the preprocessing takes about 0.5 s on theGPU, compared to 5 s with an optimized CPU implementation and 120 s with the commonly used statistical parametric mapping(SPM) software. A random permutation test with 10 000 permutations, with smoothing in each permutation, takes about 50 s ifthree GPUs are used, compared to 0.5 - 2.5 h with an optimized CPU implementation. The presented work will save time forresearchers and clinicians in their daily work and enables the use of more advanced analysis, such as non-parametric statistics, bothfor conventional fMRI and for real-time fMRI.

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  • 5.
    Gustafsson, Mikael
    et al.
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Medicinsk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
    Magnusson, Karl-Eric
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Medicinsk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
    A distributed image-processing system for measurements of intracellular calcium in living cells1991Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 36, nr 4, s. 199-221Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    During the last decade, image-processing techniques have been introduced as a valuable tool in biologically oriented research. In combination with novel fluorescent probes, these techniques permit assessment of subcellular distributions of several intracellularly important cations, such as free calcium ions and protons. Typically, systems used for image processing are located centrally around the experimental setup. This configuration has drawbacks, mainly because the laborious extraction and processing of data that generally follow an experimental session limits the access to the system for other investigators. We describe here the principles of a distributed image processing system, based on IBM-compatible personal computers (PCs), that without extra hardware can cope with all the necessary image processing involved in imaging of intracellular cations. The potential of the PC as an image processor, however, reaches beyond this specific application and many image processing tasks can be carried out successfully on a standard PC. Thus, the centrally located dedicated image processor is used only for image acquisition in the experimental situation. This in turn optimizes the utilization of expensive resources and increases efficiency. The mouse-operated software is described in detail, so that interested investigators can extract useful parts for integration into their own applications and experimental environment.

  • 6.
    Hallberg, Niklas
    et al.
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för datavetenskap, MDALAB - Human Computer Interfaces.
    Johansson, M
    Timpka, Toomas
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för hälsa och samhälle, Socialmedicin och folkhälsovetenskap. Östergötlands Läns Landsting, Folkhälsovetenskapligt centrum, Folkhälsovetenskapligt centrum.
    A prototype computer network service for occupational therapists. 1999Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 59, s. 45-54Artikel i tidskrift (Refereegranskat)
  • 7.
    Knutsson, Hans
    et al.
    Linköpings universitet, Institutionen för systemteknik, Bildbehandling. Linköpings universitet, Tekniska högskolan.
    Andersson, Mats T.
    Linköpings universitet, Institutionen för systemteknik, Bildbehandling. Linköpings universitet, Tekniska högskolan.
    Kronander, Torbjörn
    SECTRA AB, Linköping, Sweden.
    Hemmendorff, Magnus
    Linköpings universitet, Institutionen för systemteknik, Bildbehandling. Linköpings universitet, Tekniska högskolan.
    Spatio-temporal filtering of digital angiography image data1998Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 57, nr 1-2, s. 115-123Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    As welfare diseases become more common all over the world the demand for angiography examinations is increasing rapidly. The development of advanced medical signal processing methods has with few exceptions been concentrated towards CT and MR while traditional contrast based radiology depend on methods developed for ancient photography techniques despite the fact that angiography sequences are generally recorded in digital form. This article presents a new approach for processing of angiography sequences based on advanced image processing methods. The developed algorithm automatically processes angiography sequences containing motion artifacts that cannot be processed by conventional methods like digital subtraction angiography (DSA) and pixel shift due to non uniform motions. The algorithm can in simple terms be described as an ideal pixelshift filter carrying out shifts of different directions and magnitude according to the local motions in the image. In difference to conventional methods it is fully automatic, no mask image needs to be defined and the manual pixelshift operations, which are extremely time consuming, are eliminated. The algorithm is efficient and robust and is designed to run on standard hardware of a powerful workstation which excludes the need for expensive dedicated angiography platforms. Since there is no need to make additional recordings if the patient moves, the patient is exposed to less amount of radiation and contrast fluid. The most exciting benefits by this method are, however, that it opens up new areas for contrast based angiography that are not possible to process with conventional methods e.g. nonuniform motions and multiple layers of moving tissue. Advanced image processing methods provide significantly better image quality and noise suppression but do also provide the means to compute flow velocity and visualize the flow dynamics in the arterial trees by e.g. using color. Initial tests have proven that it is possible to discriminate capillary blood flow from angiography data which opens up interesting possibilities for estimating the blood flow in the heart muscle without use of nuclear methods.

  • 8.
    Kohli, Sunil
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Sahlén, K.
    Linköpings universitet, Hälsouniversitetet.
    Löfman, Owe
    Linköpings universitet, Hälsouniversitetet.
    Sivertun, Åke
    Linköpings universitet, Hälsouniversitetet.
    Foldevi, Mats
    Linköpings universitet, Institutionen för hälsa och samhälle, Allmänmedicin. Linköpings universitet, Hälsouniversitetet.
    Trell, Erik
    Linköpings universitet, Institutionen för hälsa och samhälle, Allmänmedicin. Linköpings universitet, Hälsouniversitetet.
    Wigertz, Ove
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Individuals living in areas with high background radon: a GIS method to identify populations at risk1997Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 53, nr 2, s. 105-112Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: to identify and link populations and individuals that live within high risk areas. Design: census registers and disease registers which contain data on individuals can only give aggregate statistics relating to postal code districts, town, county or state boundaries. However environmental risk factors rarely, if ever, respect these man-made boundaries. What is needed is a method to rapidly identify individuals who may live within a described area or region and to further identify the disease(s) occurring among these individuals and/or in these areas. Method: this paper describes a method for linking the standard registers available in Sweden, notably the residence-property addresses they contain and the geographical coordinate setting of these, to map the population as a point coverage. Using standard GIS methods this coverage could be linked, merged or intersected with any other map to create new subsets of population. Representation of populations down to the individual level by automatised spatialisation of available census data is in its simplicity a new informatics method which in the designated GIS medium adds a new power of resolution. Results: we demonstrate this using the radon maps provided by the local communes. The Swedish annual population registration records of 1991 for the county ofÖstergötland and the property register available at the Central Statistical Bureau of Sweden formed the main data sources. By coupling the address in the population register to the property register each individual was mapped to the centroid of a property. By intersecting the population coverage with the radon maps, the population living in high, normal or low risk areas was identified and then analysed and stratified by commune, sex and age. The resulting tables can be linked to other databases, e.g. disease registers, to visualise and analyse geographical and related patterns. The methodology can be adapted for use with any other environmental map or small area. It can also be expanded to the fourth dimension by linking likewise available migration information to generate immediately coordinate-set, accumulated exposition and similar data.

  • 9.
    Malusek, Alexandr
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet.
    Sandborg, Michael
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.
    Alm Carlsson, Gudrun
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet.
    CTmod: a toolkit for Monte Carlo simulation of projections including scatter in computed tomography2008Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 90, nr 2, s. 167-178Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The CTmod toolkit is a set of C++ class libraries based on the CERN’s application development framework ROOT. It uses the Monte Carlo method to simulate energy imparted to a CT-scanner detector array. Photons with a given angle–energy distribution are emitted from the X-ray tube approximated by a point source, transported through a phantom, and their contribution to the energy imparted per unit surface area of each detector element is scored. Alternatively, the scored quantity may be the fluence, energy fluence, plane fluence, plane energy fluence, or kerma to air in the center of each detector element. Phantoms are constructed from homogenous solids or voxel arrays via overlapping. Implemented photon interactions (photoelectric effect, coherent scattering, and incoherent scattering) are restricted to the energy range from 10 to 200 keV. Variance reduction techniques include the collision density estimator and survival biasing combined with the Russian roulette. The toolkit has been used to estimate the amount of scatter in cone beam computed tomography and planar radiography.

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  • 10.
    Nyänen, P
    et al.
    Technical Research Centre of Finland Tampere.
    Chowdhury, Shamsul
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Evaluation of decision support systems in medicine1991Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 34, s. 229-238Artikel i tidskrift (Refereegranskat)
  • 11.
    Pham, Tuan D
    School of Engineering and Information Technology, University of New South Wales, Canberra, Australia.
    Supervised restoration of degraded medical images using multiple-point geostatistics2012Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 106, nr 3, s. 201-209Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Reducing noise in medical images has been an important issue of research and development for medical diagnosis, patient treatment, and validation of biomedical hypotheses. Noise inherently exists in medical and biological images due to the acquisition and transmission in any imaging devices. Being different from image enhancement, the purpose of image restoration is the process of removing noise from a degraded image in order to recover as much as possible its original version. This paper presents a statistically supervised approach for medical image restoration using the concept of multiple-point geostatistics. Experimental results have shown the effectiveness of the proposed technique which has potential as a new methodology for medical and biological image processing.

  • 12.
    Rudowski, Robert
    et al.
    Inst Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Waraw.
    Frostell, Clas
    Danderyds sjukhus .
    Gill, Hans
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    A knowledge-based support system for mechanical ventilation of hte lungs. The KUSIVAR concept and prototype1989Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 30, s. 59-70Artikel i tidskrift (Refereegranskat)
  • 13.
    Rudowski, Robert
    et al.
    Polish Acadmy of Science Worsaw, Poland.
    Ludwigs, Ulf
    Södersjukhuset Stockholm.
    Gill, Hans
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Matuszewski, A
    Polish Academy of Science Warsaw, Poland.
    Baehrendz, S
    Karolinska Institutet Stockholm.
    Matell, George
    Karolinska Institutet Stockholm.
    Statistical models for prediction of arterial oxygen and carbon dioxide tensions during mechanical ventilation1991Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 34, s. 191-199Artikel i tidskrift (Refereegranskat)
  • 14.
    Sandborg, Michael
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Radiofysikavdelningen. Linköpings universitet, Hälsouniversitetet.
    Dance, David
    The Royal Marsden Hospital.
    Persliden, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet.
    Alm Carlsson, Gudrun
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet.
    A Monte Carlo program for the calculation of contrast, noise and absorbed dose in diagnostic radiology1994Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 42, nr 3, s. 167-180Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A Monte Carlo computer program has been developed for the simulation of X-ray photon transport in diagnostic X-ray examinations. The simulation takes account of the incident photon energy spectrum and includes a phantom (representing the patient), an anti-scatter grid and an image receptor. The primary objective for developing the program was to study and optimise the design of anti-scatter grids. The program estimates image quality in terms of contrast and signal-to-noise ratio, and radiation risk in terms of mean absorbed dose in the patient. It therefore serves as a tool for the optimisation of the radiographic procedure. A description is given of the program and the variance-reduction techniques used. The computational method was validated by comparison with measurements and other Monte Carlo simulations.

  • 15.
    Saranummi, Niilo
    et al.
    Medical Engineering Lab Tampere.
    Groth, Torgny
    Uppsala universitet .
    Rosenfalck, Annelise
    Aalborg University .
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Knowledge-based systems in medicine - a Nordic research and development programme1991Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 34, s. 81-89Artikel i tidskrift (Refereegranskat)
  • 16.
    Shahsavar, Nosrat
    et al.
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Gill, Hans
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Frostell, Claes
    Danderyds Hospital .
    Matell, George
    Södersjukhuset Stockholm.
    Ludwigs, Ulf
    Södersjukhuset Stockholm.
    KAVE: a tool for knowledge acquisition to support artificial ventilation1991Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 34, s. 115-123Artikel i tidskrift (Refereegranskat)
  • 17.
    Singh, A.K.
    et al.
    Rajasthan India.
    Moidu, Khalid
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Trell, Erik
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för hälsa och samhälle, Allmänmedicin.
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Impact on the management and delivery of primary health care by a computer-based information system1992Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 37, s. 55-64Artikel i tidskrift (Refereegranskat)
  • 18.
    Smedby, Örjan
    Department of Diagnostic Radiology, Uppsala University.
    A scanning system for digital analysis of cineangiography films1992Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 39, nr 1-2, s. 103-111Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A system for scanning and digital analysis of cinefilms is presented and its performance is compared with entirely digital radiographic equipment. Apart from the difference between logarithmic and linear gray-scale representation, a higher noise level was found in the scanning system. When its spatial resolution was assessed visually, it was comparable to that of the digital system, although lower than when the cinefilming and scanning steps were evaluated separately. Algorithms for the correction of varying exposure and geometric ("pin-cushion") distortion are also presented. It is concluded that digital analysis after scanning of cinefilms can be a useful alternative to completely digital cineradiographic studies.

  • 19.
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Clinical decision support - how, when and for whom1995Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 48, s. 15-20Artikel i tidskrift (Refereegranskat)
  • 20.
    Xiao-Ming, Gao
    et al.
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Johansson, Bo
    IMT .
    Shahsavar, Nosrat
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Arkad, Kristina
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Åhlfeldt, Hans
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Pre-compiling medical logic modules into C++ in building medical decision support systems1993Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 41, s. 107-119Artikel i tidskrift (Refereegranskat)
  • 21.
    Zhou, Yijun
    et al.
    Div. of Biomedical Engineering, Dept. of Materials Science and Engineering, Uppsala University, Sweden.
    Klintström, Eva
    Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för diagnostik och specialistmedicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Klintström, Benjamin
    Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge, Sweden.
    Ferguson, Stephen J.
    Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.
    Helgason, Benedikt
    Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.
    Persson, Cecilia
    Div. of Biomedical Engineering, Dept. of Materials Science and Engineering, Uppsala University, Sweden.
    A convolutional neural network-based method for the generation of super-resolution 3D models from clinical CT images2024Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 245, artikel-id 108009Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background and Objective

    The accurate evaluation of bone mechanical properties is essential for predicting fracture risk based on clinical computed tomography (CT) images. However, blurring and noise in clinical CT images can compromise the accuracy of these predictions, leading to incorrect diagnoses. Although previous studies have explored enhancing trabecular bone CT images to super-resolution (SR), none of these studies have examined the possibility of using clinical CT images from different instruments, typically of lower resolution, as a basis for analysis. Additionally, previous studies rely on 2D SR images, which may not be sufficient for accurate mechanical property evaluation, due to the complex nature of the 3D trabecular bone structures. The objective of this study was to address these limitations.

    Methods

    A workflow was developed that utilizes convolutional neural networks to generate super-resolution 3D models across different clinical CT instruments. The morphological and finite-element-derived mechanical properties of these super-resolution models were compared with ground truth models obtained from micro-CT scans.

    Results

    A significant improvement in analysis accuracy was demonstrated, where the new SR models increased the accuracy by up to 700% compared with the low-resolution data, i.e. clinical CT images. Additionally, we found that the mixture of different CT image datasets may improve the super-resolution model performance.

    Conclusions

    Super-resolution images, generated by convolutional neural networks, outperformed clinical CT images in the determination of morphological and mechanical properties. The developed workflow could be implemented for fracture risk prediction, potentially leading to improved diagnoses and subsequent clinical decision making.

  • 22.
    Åhlfeldt, Hans
    et al.
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Shahsavar, Nosrat
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Xiao-Ming, Gao
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Arkad, Kristina
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Johansson, Bo
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Wigertz, Ove
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik.
    Data driven medical decision support based on Arden Syntax within the HELIOS environment1994Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 45, nr suppl, s. S97-S106Artikel i tidskrift (Refereegranskat)
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