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  • 1.
    Couto, A
    et al.
    Austrian Academy of Science.
    Alenius, Mattias
    Austrian Academy of Science.
    Dickson, BJ
    Austrian Academy of Science.
    Molecular, anatomical, and functional organization of the Drosophila olfactory system2005In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 15, no 17, p. 1535-1547Article in journal (Refereed)
    Abstract [en]

    Background: Olfactory receptor neurons (ORNs) convey chemical information into the brain, producing internal representations of odors detected in the periphery. A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at singlecell resolution. Results: We have constructed near-complete maps of Or expression and ORN targeting in the Drosophila olfactory system. These maps confirm the general validity of the "one neuron-one receptor" and "one glomerulus-one receptor" principles and reveal several additional features of olfactory organization. ORNs in distinct sensilla types project to distinct regions of the antenna[ lobe, but neighbor relations are not preserved. ORNs grouped in the same sensilla do not express similar receptors, but similar receptors tend to map to closely appositioned glomeruli in the antennal lobe. This organization may serve to ensure that odor representations are dispersed in the periphery but clustered centrally. Integrated with electrophysiological data, these maps also predict glomerular representations of specific odorants. Representations of aliphatic and aromatic compounds are spatially segregated, with those of aliphatic compounds arranged topographically according to carbon chain length. Conclusions: These Or expression and ORN connectivity maps provide further insight into the molecular, anatomical, and functional organization of the Drosophila olfactory system. Our maps also provide an essential resource for investigating how internal odor representations are generated and how they are further processed and transmitted to higher brain centers.

  • 2.
    Dean, Rebecca
    et al.
    University of Oxford, UK.
    Cornwallis, Charlie K
    University of Oxford, UK.
    Løvlie, Hanne
    University of Oxford, UK; Stockholm University, Sweden.
    Worley, Kirsty
    University of Oxford, UK; University of East Anglia, UK.
    Richardson, David S.
    University of East Anglia, UK.
    Pizzari, Tommaso
    University of Oxford, UK.
    Male reproductive senescence causes potential for sexual conflict over mating2010In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 20, no 13, p. 1192-1196Article in journal (Refereed)
    Abstract [en]

    The realization that senescence, age-dependent declines in survival and reproductive performance, pervades natural populations has brought its evolutionary significance into sharper focus. However, reproductive senescence remains poorly understood because it is difficult to separate male and female mechanisms underpinning reproductive success. We experimentally investigated male reproductive senescence in feral fowl, Gallus gallus domesticus, where socially dominant males monopolize access to females and the ejaculates of multiple males compete for fertilization. We detected the signal of senescence on multiple determinants of male reproductive success. The effect of age on status was dependent upon the intensity of intrasexual competition: old males were less likely to dominate male-biased groups where competition is intense but were as likely as young males to dominate female-biased groups. Mating and fertilization success declined sharply with male age largely as a result of population-level patterns. These age-dependent declines translated into sexually antagonistic payoffs: old males fertilized more eggs when they were dominant, but this resulted in females suffering a drastic reduction in fertility. Thus, male senescence causes potential for sexual conflict over mating, and the intensity of this conflict is modulated socially, by the probability of old males dominating reproductive opportunities.

  • 3.
    Fernius, Josefin
    et al.
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, UK.
    Nerusheva, Olga O.
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, UK.
    Galander, Stefan
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, UK.
    Alves, Flavia de Lima
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, UK.
    Rappsilber, Juri
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, UK.
    Marston, Adele L.
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, UK.
    Cohesin-dependent association of scc2/4 with the centromere initiates pericentromeric cohesion establishment2013In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 23, no 7, p. 599-606Article in journal (Refereed)
    Abstract [en]

    Cohesin is a conserved ring-shaped multiprotein complex that participates in chromosome segregation, DNA repair, and transcriptional regulation [1, 2]. Cohesin loading onto chromosomes universally requires the Scc2/4 "loader" complex (also called NippedBL/Mau2), mutations in which cause the developmental disorder Cornelia de Lange syndrome in humans [1-9]. Cohesin is most concentrated in the pericentromere, the region surrounding the centromere [10-15]. Enriched pericentromeric cohesin requires the Ctf19 kinetochore subcomplex in budding yeast [16-18]. Here, we uncover the spatial and temporal determinants for Scc2/4 centromere association. We demonstrate that the critical role of the Ctf19 complex is to enable Scc2/4 association with centromeres, through which cohesin loads and spreads onto the adjacent pericentromere. We show that, unexpectedly, Scc2 association with centromeres depends on cohesin itself. The absence of the Scc1/Mcd1/Rad21 cohesin subunit precludes Scc2 association with centromeres from anaphase until late G1. Expression of SCC1 is both necessary and sufficient for the binding of cohesin to its loader, the association of Scc2 with centromeres, and cohesin loading. We propose that cohesin triggers its own loading by enabling Scc2/4 to connect with chromosomal landmarks, which at centromeres are specified by the Ctf19 complex. Overall, our findings provide a paradigm for the spatial and temporal control of cohesin loading.

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  • 4.
    Grenzi, Matteo
    et al.
    Univ Milan, Italy.
    Buratti, Stefano
    Univ Milan, Italy.
    Parmagnani, Ambra Selene
    Univ Milan, Italy.
    Abdel Aziz, Ilaria
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Bernacka Wojcik, Iwona
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Resentini, Francesca
    Univ Milan, Italy.
    Simura, Jan
    Swedish Univ Agr Sci, Sweden.
    Doccula, Fabrizio Gandolfo
    Univ Milan, Italy.
    Alfieri, Andrea
    Univ Milan, Italy; Univ Pavia, Italy.
    Luoni, Laura
    Univ Milan, Italy.
    Ljung, Karin
    Swedish Univ Agr Sci, Sweden.
    Bonza, Maria Cristina
    Univ Milan, Italy.
    Stavrinidou, Eleni
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. Swedish Univ Agr Sci, Sweden.
    Costa, Alex
    Univ Milan, Italy; Natl Res Council Italy CNR, Italy.
    Long-distance turgor pressure changes induce local activation of plant glutamate receptor-like channels2023In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 33, no 6, p. 1019-+Article in journal (Refereed)
    Abstract [en]

    In Arabidopsis thaliana, local wounding and herbivore feeding provoke leaf-to-leaf propagating Ca2+ waves that are dependent on the activity of members of the glutamate receptor-like channels (GLRs). In systemic tissues, GLRs are needed to sustain the synthesis of jasmonic acid (JA) with the subsequent activation of JA dependent signaling response required for the plant acclimation to the perceived stress. Even though the role of GLRs is well established, the mechanism through which they are activated remains unclear. Here, we report that in vivo, the amino-acid-dependent activation of the AtGLR3.3 channel and systemic responses require a functional ligand-binding domain. By combining imaging and genetics, we show that leaf mechanical injury, such as wounds and burns, as well as hypo-osmotic stress in root cells, induces the systemic apoplastic increase of L-glutamate (L-Glu), which is largely independent of AtGLR3.3 that is instead required for systemic cytosolic Ca2+ elevation. Moreover, by using a bioelectronic approach, we show that the local release of minute concentrations of L-Glu in the leaf lamina fails to induce any long-distance Ca2+ waves.

  • 5.
    Guterstam, Arvid
    et al.
    Karolinska Institute, Sweden.
    Björnsdotter Åberg, Malin
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Institute, Sweden.
    Gentile, Giovanni
    Karolinska Institute, Sweden.
    Ehrsson, H. Henrik
    Karolinska Institute, Sweden.
    Posterior Cingulate Cortex Integrates the Senses of Self-Location and Body Ownership2015In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 25, no 11, p. 1416-1425Article in journal (Refereed)
    Abstract [en]

    The senses of owning a body and being localized somewhere in space are two key components of human self-consciousness. Despite a wealth of neurophysiological and neuroimaging research on the representations of the spatial environment in the parietal and medial temporal cortices, the relationship between body ownership and self-location remains unexplored. To investigate this relationship, we used a multisensory out-of-body illusion to manipulate healthy participants perceived self-location, head direction, and sense of body ownership during high-resolution fMRI. Activity patterns in the hippocampus and the posterior cingulate, retrosplenial, and intraparietal cortices reflected the sense of self-location, whereas the sense of body ownership was associated with premotor-intraparietal activity. The functional interplay between these two sets of areas was mediated by the posterior cingulate cortex. These results extend our understanding of the role of the posterior parietal and medial temporal cortices in spatial cognition by demonstrating that these areas not only are important for ecological behaviors, such as navigation and perspective taking, but also support the perceptual representation of the bodily self in space. Our results further suggest that the posterior cingulate cortex has a key role in integrating the neural representations of self-location and body ownership.

  • 6.
    Lao, O.
    et al.
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands.
    Lu, T.T.
    Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Nothnagel, M.
    Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Junge, O.
    Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Freitag-Wolf, S.
    Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Caliebe, A.
    Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Balascakova, M.
    Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic.
    Bertranpetit, J.
    Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain.
    Bindoff, L.A.
    Department of Neurology, Haukeland University Hospital, Institute of Clinical Medicine, 5021 Bergen, Norway.
    Comas, D.
    Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain.
    Holmlund, Gunilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. National Board of Forensic Medicine, Linköping, Sweden.
    Kouvatsi, A.
    Department of Genetics, Development, and Molecular Biology, Aristotle University of Thessaloniki, GR-540 06 Thessaloniki, Greece.
    Macek, M.
    Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic.
    Mollet, I.
    Laboratoire d'Empreintes Génétiques, EFS-RA site de Lyon, 69007 Lyon, France.
    Parson, W.
    Institute of Legal Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria.
    Palo, J.
    Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland.
    Ploski, R.
    Department of Medical Genetics, Medical University Warsaw, 02-007 Warsaw, Poland.
    Sajantila, A.
    Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland.
    Tagliabracci, A.
    Istituto di Medicina Legale, University of Ancona, I-60020 Ancona, Italy.
    Gether, U.
    Molecular Neuropharmacology Group, Center for Pharmacogenomics Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark.
    Werge, T.
    Research Institute of Biological Psychiatry, Center for Pharmacogenomics, Mental Health Center Sct. Hans, DK-4000 Roskilde, Denmark.
    Rivadeneira, F.
    Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands.
    Hofman, A.
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands.
    Uitterlinden, A.G.
    Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands.
    Gieger, C.
    Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany.
    Wichmann, H.-E.
    Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany.
    Ruther, A.
    Rüther, A., Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Schreiber, S.
    Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Becker, C.
    Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany.
    Nurnberg, P.
    Nürnberg, P., Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany.
    Nelson, M.R.
    Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, United States.
    Krawczak, M.
    Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany.
    Kayser, M.
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands.
    Correlation between Genetic and Geographic Structure in Europe2008In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 18, no 16, p. 1241-1248Article in journal (Refereed)
    Abstract [en]

    Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry. © 2008 Elsevier Ltd. All rights reserved.

  • 7.
    Løvlie, Hanne
    et al.
    Stockholm University, Sweden.
    Cornwallis, Charles K.
    University of Sheffield, UK.
    Pizzari, Tommaso
    University of Oxford, UK.
    Male mounting alone reduces female promiscuity in the fowl2005In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 15, no 13, p. 1222-1227Article in journal (Refereed)
    Abstract [en]

    The fertilization success of an insemination is at risk when a female has the possibility to copulate with multiple males, generating sperm competition and sexual conflict over remating. Female propensity to remate is often reduced after copulation, and a staggering diversity of highly derived male traits that discourage female promiscuity have been investigated. However, it is difficult to separate the effect of such specialized traits and insemination products from the more basic effect that the act of mounting per se may have on female remating. Here, we use a novel approach that separates the influence of mounting from that of insemination on female remating in the promiscuous feral fowl. Mounting alone caused a transient but drastic reduction in female propensity to remate, and-crucially-the number of sperm that a female obtained from a new male. Therefore, like other taxa, female fowl show a reduction in promiscuity after copulation, but this is entirely due to mounting alone. This effect of mounting, independent of insemination and fertilization, indicates that even copulations that deliver little or no semen, a puzzling behavior common in many species including the fowl, may play a crucial role in sperm competition.

  • 8.
    Maklakov, Alexei A.
    et al.
    Uppsala University, Sweden.
    Friberg, Urban
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Ageing: Why Males Curtail the Longevity of Their Mates2016In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 26, no 20, p. R929-R932Article in journal (Other academic)
    Abstract [en]

    Male nematodes secrete pheromones that accelerate the somatic senescence of potential mates. A new study shows that this harm most likely is an unintended by-product of the males aim to speed up sexual maturation and delay reproductive senescence of future partners.

  • 9.
    Malmstrom, Helena
    et al.
    Uppsala University.
    Thomas P. Gilbert, M.
    University of Copenhagen.
    G. Thomas, Mark
    UCL.
    Brandstrom, Mikael
    Swedish University of Agricultural Science.
    Stora, Jan
    Stockholm University.
    Molnar, Petra
    Stockholm University.
    KAndersen, Pernille K
    University of Aarhus.
    Bendixen, Christian
    University of Aarhus.
    Holmlund, Gunilla
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Gotherstrom, Anders
    Uppsala University.
    Willerslev, Eske
    University of Copenhagen.
    Ancient DNA Reveals Lack of Continuity between Neolithic Hunter-Gatherers and Contemporary Scandinavians2009In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 19, no 20, p. 1758-1762Article in journal (Refereed)
    Abstract [en]

    The driving force behind the transition from a foraging to a farming lifestyle in prehistoric Europe (Neolithization) has been debated for more than a century[1-3]. Of particular interest is whether population replacement or cultural exchange was responsible [3-5]. Scandinavia holds a unique place in this debate, for it maintained one of the last major hunter-gatherer complexes in Neolithic Europe, the Pitted Ware culture [6]. Intriguingly, these late hunter-gatherers existed in parallel to early farmers for more than a millennium before they vanished some 4,000 years ago [7, 8]. The prolonged coexistence of the two cultures in Scandinavia has been cited as an argument against population replacement between the Mesolithic and the present [7, 8]. Through analysis of DNA extracted from ancient Scandinavian human remains, we show that people of the Pitted Ware culture were not the direct ancestors of modern Scandinavians (including the Saami people of northern Scandinavia) but are more closely related to contemporary populations of the eastern Baltic region. Our findings support hypotheses arising from archaeological analyses that propose a Neolithic or post-Neolithic population replacement in Scandinavia [7]. Furthermore, our data are consistent with the view that the eastern Baltic represents a genetic refugia for some of the European hunter-gatherer populations.

  • 10.
    Monedero Cobeta, Ignacio
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Yaghmaeian Salmani, Behzad
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Thor, Stefan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Anterior-Posterior Gradient in Neural Stem and Daughter Cell Proliferation Governed by Spatial and Temporal Hox Control2017In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 27, no 8, p. 1161-1172Article in journal (Refereed)
    Abstract [en]

    A readily evident feature of animal central nervous systems (CNSs), apparent in all vertebrates and many invertebrates alike, is its "wedge-like appearance, with more cells generated in anterior than posterior regions. This wedge could conceivably be established by an antero-posterior (A-P) gradient in the number of neural progenitor cells, their proliferation behaviors, and/or programmed cell death (PCD). However, the contribution of each of these mechanisms, and the underlying genetic programs, are not well understood. Building upon recent progress in the Drosophila melanogaster (Drosophila) ventral nerve cord (VNC), we address these issues in a comprehensive manner. We find that, although PCD plays a role in controlling cell numbers along the A-P axis, the main driver of the wedge is a gradient of daughter proliferation, with divisions directly generating neurons (type 0) being more prevalent posteriorly and dividing daughters (type I) more prevalent anteriorly. In addition, neural progenitor (NB) cell-cycle exit occurs earlier posteriorly. The gradient of type I amp;gt; 0 daughter proliferation switch and NB exit combine to generate radically different average lineage sizes along the A-P axis, differing by more than 3-fold in cell number. We find that the Hox homeotic genes, expressed in overlapping A-P gradients and with a late temporal onset in NBs, trigger the type I amp;gt; 0 daughter proliferation switch and NB exit. Given the highly evolutionarily conserved expression of overlapping Hox homeotic genes in the CNS, our results point to a common mechanism for generating the CNS wedge.

  • 11.
    Petkova, Valeria I
    et al.
    Brain, Body & Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Björnsdotter, Malin
    Brain, Body & Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Gentile, Giovanni
    Brain, Body & Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Jonsson, Tomas
    Department of Medical Physics, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    Li, Tie-Qiang
    Department of Medical Physics, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    Ehrsson, H Henrik
    Brain, Body & Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    From part- to whole-body ownership in the multisensory brain.2011In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 21, no 13, p. 1118-1122Article in journal (Refereed)
    Abstract [en]

    The question of how we experience ownership of an entire body distinct from the external world is a fundamental problem in psychology and neuroscience [1-6]. Earlier studies suggest that integration of visual, tactile, and proprioceptive information in multisensory areas [7-11] mediates self-attribution of single limbs. However, it is still unknown how ownership of individual body parts translates into the unitary experience of owning a whole body. Here, we used a "body-swap" illusion [12], in which people experienced an artificial body to be their own, in combination with functional magnetic resonance imaging to reveal a coupling between the experience of full-body ownership and neural responses in bilateral ventral premotor and left intraparietal cortices, and left putamen. Importantly, activity in the ventral premotor cortex reflected the construction of ownership of a whole body from the parts, because it was stronger when the stimulated body part was attached to a body, was present irrespective of whether the illusion was triggered by stimulation of the hand or the abdomen, and displayed multivoxel patterns carrying information about full-body ownership. These findings suggest that the unitary experience of owning an entire body is produced by neuronal populations that integrate multisensory information across body segments.

  • 12.
    Thor, Stefan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Nervous System Development: Temporal Patterning of Large Neural Lineages2017In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 27, no 10, p. R392-R394Article in journal (Other academic)
    Abstract [en]

    n/a

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