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  • 1.
    Miehlke, Stephan
    et al.
    Internal Med Ctr Eppendorf, Germany; Univ Hosp Eppendorf, Germany.
    Verhaegh, Bas
    Maastricht Univ, Netherlands.
    Tontini, Gian Eugenio
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy.
    Madisch, Ahmed
    CRH Clin Siloah, Germany.
    Langner, Cord
    Med Univ Graz, Austria.
    Münch, Andreas
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology.
    Microscopic colitis: pathophysiology and clinical management2019In: The Lancet Gastroenterology & Hepatology, ISSN 2468-1253, Vol. 4, no 4, p. 305-314Article, review/survey (Refereed)
    Abstract [en]

    Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished-collagenous colitis and lymphocytic colitis-but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity.

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