liu.seSearch for publications in DiVA
Change search
Refine search result
1 - 10 of 10
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Bauhofer, A.
    et al.
    Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Lorenz, W.
    Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Stinner, B.
    Department of General Surgery, Philipps-University Marburg, Germany.
    Rothmund, M.
    Department of General Surgery, Philipps-University Marburg, Germany.
    Koller, M.
    Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Sitter, H.
    Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Celik, I.
    Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Farndon, J.R.
    Department of Surgery, Bristol Royal Infirmary, Bristol, United Kingdom.
    Fingerhut, A.
    Department of Surgery, Centre Hospitalier Intercommunal, Poissy, France.
    Hay, J.M.
    Department of Surgery, Hopital Louis Mourier, Colombes, France.
    Lefering, R.
    2nd Department of Surgery, University of Cologne, Germany.
    Lorijn, R.
    AMGEN Europe, Lucerne, Switzerland.
    Nyström, Per-Olof
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Schafer, H.
    Schäfer, H., Institute of Medical Biometrics and Epidemiology, Philipps-University Marburg, Germany.
    Schein, M.
    Department of Surgery, New York Methodist Hospital, Cornell University, United States.
    Solomkin, J.
    Department of Surgery, University of Cincinnati, College of Medicine, United States.
    Troidl, H.
    2nd Department of Surgery, University of Cologne, Germany.
    Volk, H.-D.
    Institute of Medical Immunology, Humboldt-University Berlin, Germany.
    Wittmann, D.H.
    Department of Surgery, Medical College of Wisconsin, Milwaukee, United States.
    Wyatt, J.
    School of Public Policy, University College London, United Kingdom.
    Granulocyte-colony stimulating factor in the prevention of postoperative infectious complications and sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4). Protocol for a controlled clinical trial developed by consensus of an international study group: Part two2001In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 50, no 4, p. 187-205Article, review/survey (Refereed)
    Abstract [en]

    General design: Presentation of a new type of a study protocol for evaluation of the effectiveness of an immune modifier (rhG-CSF, filgrastim): prevention of postoperative infectious complications and of sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4) This part describes the design of the randomised, placebo controlled, double-blinded, single-centre study performed at an university hospital (n = 40 patients for each group). Objective: The trial design includes the following elements for a prototype protocol: - The study population is restricted to patients with colorectal cancer, including a left sided resection and an increased perioperative risk (ASA 3 and 4). - Patients are allocated by random to the control or treatment group. - The double blinding strategy of the trial is assessed by psychometric indices - An endpoint construct with quality of life (EORTC QLQ-C30) and a recovery index (modified Mc Peek index) are used as primary endpoints Qualitative analysis of clinical relevance of the endpoints is performed by both patients and doctors. - Statistical analysis uses an area under the curve (AUC) model for improvement of quality of life on leaving hospital and two and six months after operation. A confirmatory statistical model with quality of life as the first primary endpoint in the hierarchic test procedure is used. Expectations of patients and surgeons and the negative affect are analysed by social psychological scales. Conclusion: This study design differs from other trials on preoperative prophylaxis and postoperative recovery, and has been developed to try a new concept and avoid previous failures.

  • 2.
    Davidsson, Anette
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Clinical Physiology . Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Schmekel, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Clinical Physiology . Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Histamine release from blood cells and serum ECP in patients with asthma, during and after a mild pollen season2005In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 54, p. S76-S77Article in journal (Refereed)
  • 3. Fogel, WA
    et al.
    Andrzejewski, W
    Sasiak, K
    Granerus, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Lönnqvist, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology.
    Tuomisto, L
    Tarhanen, J
    Can urinary N-tele methylimidazoleacetic acid (t-MeImAA) serve as a marker of histaminergic activity in hepatic encephalopathy (HE)?2002In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 51, no SUPPL.1Article in journal (Refereed)
  • 4.
    Fägerstam, JP
    et al.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Whiss, PA
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Ström, Magnus
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, GE: gastromed.
    Andersson, RGG
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease2000In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 49, no 9, p. 466-472Article in journal (Refereed)
    Abstract [en]

    Objective and Design: P-selectin, a membrane glycoprotein which is expressed on activated platelets and endothelial cells, plays a crucial role in the inflammatory response. The main action is adhesion of leukocytes, facilitation of diapedesis and induction of cytokine production from monocytes (MCP-1 and IL-8), mediated via RANTES released from activated platelets. An abnormal platelet activity has been reported in patients with ulcerative colitis (uc) and Crohn's disease (CD), jointly referred to as inflammatory bowel disease (IBD), which could have an aggravating influence on the inflammatory response. In addition, an up-regulation of platelet IL-8 receptors among patients with IBD has been reported. To reveal a presumptuous platelet dysfunction we analysed the expression of platelet surface P-selectin at resting state and after stimulation with thrombin, collagen, epinephrine and interleukin 8 (IL-8), and plasma levels of soluble P-selectin, neuropeptide Y (NPY) and RANTES in patients with IBD. Subjects: Blood from twelve healthy subjects (control group) and twenty-one patients with IBD who had not taken any anti-platelet drugs or steroids were analysed. Methods: Patients were sub-grouped according to disease entity, disease activity and 5ASA medication. Surface P-selectin expression on isolated human platelets and plasma P-selectin, NPY and RANTES were analysed with ELISA. All values are presented as mean ▒ standard error of the mean (SEM). Mann-Whitney U test and Wilcoxon matched rank test were used for statistical analyses. Results: Patients with IBD in remission (n = 9) had higher basal P-selectin expression, 0.38 ▒ 0.04, compared to the control group (n = 12), 0.22 ▒ 0.03, p < 0.01. UC patients (n = 16) showed down-regulation of P-selectin expression after stimulation with IL-8, 0.26 ▒ 0.03 to 0.22 ▒ 0.02, p < 0.05. No significant differences could be observed concerning soluble P-selectin and NPY in plasma. Patients with 5ASA (n = 12) had lower levels of plasma RANTES, 2.39 ▒ 0.06 ╡g/l, compared to the control group (n = 12), 3.29 ▒ 0.19 ╡g/l, p < 0.01, and patients without 5ASA (n = 9), 2.90 ▒ 0.17 ╡g/l, p < 0.05. Conclusions: Patients with IBD in remission have higher basal platelet surface P-selectin expression. An exaggerated platelet activity with increased expression of platelet P-selectin and release of inflammatory mediators such as RANTES, which is chemotactic and induce chemokine production, could have a reinforcing and aggravating influence on the inflammatory response and increase the susceptibility to IBD. In addition IL-8 has a down-regulating effect on platelet surface P-selectin expression and 5ASA medication seems to lower plasma RANTES. If 5ASA is responsible for lowering the concentration of RANTES this could be one of the beneficial outcomes of 5ASA medication.

  • 5.
    Granerus, Göran
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Lönnqvist, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology.
    Stenström, Mats
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radio Physics.
    No sex difference in the urinary excretion of the histamine metabolite methlimidazoleacetic acid (MeImAA) when corrected for creatinine excretion.1999In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 48, p. 92-93Article in journal (Refereed)
  • 6.
    Granerus, Göran
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Lönnqvist, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology.
    Wass, U
    Determination of the histamine metabolite telemethlimidazoleatic acid and of creatinine in urine by the same HPLC systems.1999In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 48, p. 75-80Article in journal (Refereed)
  • 7.
    Johansson, A-C
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Nursing Science.
    Lönnqvist, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Granerus, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    The relationship between body size and the urinary excretion of the main histamine metabolite tele-methylimidazoleacetic acid in man2001In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 50, no SUPPL. 2Article in journal (Refereed)
  • 8.
    Larsson, Jenny
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Pathology. Linköping University, Faculty of Health Sciences.
    Serrander, Lena
    Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Stendahl, Olle
    Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Lundqvist-Gustafsson, Helen
    Linköping University, Department of Neuroscience and Locomotion, Pathology. Linköping University, Faculty of Health Sciences.
    Involvement of the ß2-integrin CD18 in apoptosis signal transduction in human neutrophils2000In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 49, no 9, p. 452-459Article in journal (Refereed)
    Abstract [en]

    Objective and design: To examine the hypothesis that an accelerated rate of neutrophil apoptosis occurs following β2-integrin activation, and further investigate the signal transduction pathways involved.

    Material: Human polymorphonuclear neutrophils.

    Treatment: Neutrophils were challenged with pansorbins coated with antibodies towards the β2-integrin subunit CD18 in a proportion of 1:100 with or without the inhibitors diphenylene iodonium (10 M), cytochalasin B (5 μg/ml), genistein (10 nM), herbimycin A (10 M) and Z-VAD-FMK (10 μM).

    Methods: Measurement of phosphatidylserine exposure and DNA fragmentation in flow cytometry and assessment of H2O2-production through spectrofluorometry. The results were analysed using Mann Whitney U test and Kruskal Wallis.

    Results: Pansorbins coated with antibodies to CD18 induce apoptosis in neutrophils (p < 0.01), and activate the production of reactive oxygen species (p < 0.01). Pre-treatment with the inhibitors have no effect on anti-CD18 induced apoptosis.

    Conclusion: Anti-CD18 pansorbins induce apoptosis in neutrophils through an alternative pathway not involving reactive oxygen species and independent of tyrosine phosphorylation, cytoskeletal reorganisation and caspases.

  • 9.
    Lorenz, W.
    et al.
    Institute of Theoretical Surgery, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Stinner, B.
    Department of General Surgery, Philipps-University of Marburg, Germany.
    Bauhofer, A.
    Institute of Theoretical Surgery, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Rothmund, M.
    Department of General Surgery, Philipps-University of Marburg, Germany.
    Celik, I.
    Institute of Theoretical Surgery, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Fingerhut, A.
    Surgical Unit, Centre Hospitalier Intercommunal, Poissy (Paris), France.
    Koller, M.
    Institute of Theoretical Surgery, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Lorijn, R.H.W.
    AMGEN Europe, Lucerne, Switzerland.
    Nyström, Per-Olof
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Sitter, H.
    Institute of Theoretical Surgery, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany.
    Schein, M.
    Cornell University, Medical College, NY, United States.
    Solomkin, J.S.
    Department of Surgery, University of Cincinnati College of Medicine, United States.
    Troidl, H.
    2nd Department of Surgery, University of Cologne, Germany.
    Wyatt, J.
    School of Public Policy, University College London, United Kingdom.
    Wittmann, D.H.
    Department of Surgery, Medical College of Wisconsin, Milwaukee, United States.
    Granulocyte-colony stimulating factor in the prevention of postoperative infectious complications and sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4): Part one2001In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 50, no 3, p. 115-122Article, review/survey (Refereed)
    Abstract [en]

    General design: Presentation of a novel study protocol to evalue the effectiveness of an immune modifier (rhG-CSF, filgrastim): prevention of postoperative infectious complications and sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4). The rationale and hypothesis are presented in this part of the protocol of the randomised, placebo controlled, double-blinded, single-centre study performed at an - university hospital (n = 40 patients for each group). Objective: Part one of this protocol describes the concepts of three major sections of the study: - Definition of optimum and sub-optimal recovery after operation. Recovery, as an outcome, is not a simple univariate endpoint, but a complex construction of mechanistic variables (i. e. death, complications and health status assessed by the surgeon), quality of life expressed by the patient, and finally a weighted outcome judgement by both the patient and the surgeon (true endpoint). Its conventional early assessment within 14-28 days is artificial: longer periods (such as 6 months) are needed for the patient to state: "I am now as well as I was before". Identification of suitable target patients: - the use of biological response modifiers (immune modulators) in addition to traditional prophylaxes (i. e. antibiotics, heparin, volume substitutes) may improve postoperative outcome in appropriate selected patients with reduced host defence and increased immunological stress response, but these have to be defined. Patients classified as ASA 3 and 4 (American Society for Anaesthesiologists) and with colorectal cancer will be studied to prove this hypothesis. Choice of biological response modifier: - Filgrastim has been chosen as an example of a biological response modifier because it was effective in a new study type, clinic-modelling randomised trials in rodents, and has shown promise in some clinical trials for indications other than preoperative prophylaxis. It has also enhanced host defence and has been anti-inflammatory in basic research. Conclusion: The following hypothesis will be tested in patients with operations for colorectal cancer and increased preoperative risk (ASA 3 and 4): is the outcome as evaluated by the hermeneutic endpoint (quality of life expressed by the patient) and mechanistic endpoints (mortality rate, complication rate, relative hospital stay, assessed by the doctor) improved in the group receiving filgrastim prophylaxis in comparison with the placebo group? Quality of life will be the first primary endpoint in the hierarchical, statistical testing of confirmatory analysis.

  • 10.
    Stinner, B
    et al.
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Bauhofer, A
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Lorenz, W
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Rothmund, M
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Plaul, U
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Torossian, A
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Celik, I
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Sitter, H
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Koller, M
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Black, A
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Duda, D
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Encke, A
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Greger, B
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    van Goor, H
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Hanisch, E
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Hesterberg, R
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Klose, KJ
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Lacaine, F
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Lorijn, RHW
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Margolis, C
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Neugebauer, E
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Nyström, Per-Olof
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Reemst, PHM
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Schein, M
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Solovera, J
    Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg, Dept Gen Surg, D-35032 Marburg, Germany Univ Marburg, Dept Anaesthesia & Intens Care Med, D-35032 Marburg, Germany Bristol Royal Infirm, Dept Anaesthesia, Bristol, Avon, England Rot Kreuz Clin, Dept Surg, Kassel, Germany Univ Frankfurt, Dept Surg, D-6000 Frankfurt, Germany Dept Surg, Lichtenfels, Germany Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands Knappschafts Clin, Dept Surg, Dortmund, Germany St Hildegardes Clin, Dept Anaesthesia, Mainz, Germany Univ Marburg, Dept Radiol, D-35032 Marburg, Germany Hosp Tenon, Dept Surg, Paris, France Amgen Inc Europe, Lucerne, Switzerland Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Med Descis Making, IL-84105 Beer Sheva, Israel Univ Cologne, Dept Surg 2, Biochem & Expt Div, D-5000 Cologne 41, Germany Linkoping Univ, Dept Med Surg Gastroenterol, S-58183 Linkoping, Sweden Diakonissenhuis, Dept Surg, Eindhoven, Netherlands Cornell Univ, New York Methodist Hosp, Dept Surg, Ithaca, NY 14853 USA.
    Granulocyte-colony stimulating factor in the prevention of postoperative infectious complications and sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4) - Protocol of a controlled clinical trial developed by consensus of an international study group Part three: individual patient, complication algorithm and quality management2001In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 50, no 5, p. 233-248Article, review/survey (Refereed)
    Abstract [en]

    General design: Presentation of a new type of a study protocol for evaluation of the effectiveness of an immune modifier (rhG-CSF, filgrastim): prevention of postoperative infectious complications and of sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4). A randomised placebo controlled, double-blinded, single-centre study is performed at an University Hospital (n = 40 patients for each group). This part presents the course of the individual patient and a complication algorithm for the management of anastomotic leakage and quality management. Objective: In part three of the protocol, the three major sections include: - The course of the individual patient using a comprehensive graphic display, including the perioperative period, hospital stay and post discharge outcome. - A center based clinical practice guideline for the management of the most important postoperative complication anastomotic leakage - including evidence based support for each step of the algorithm. - Data management, ethics and organisational structure. Conclusions: Future studies with immune modifiers will also fail if not better structured (reduction of variance) to achieve uniform patient management in a complex clinical scenario. This new type of a single-centre trial aims to reduce the gap between animal experiments and clinical trials or - if it fails - at least demonstrates new ways for explaining the failures.

1 - 10 of 10
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf