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  • 1.
    Ludvigsson, Johnny
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Immune intervention in children with type 1 diabetes2010In: Current Diabetes Reports, ISSN 1534-4827, E-ISSN 1539-0829, Vol. 10, no 5, p. 370-379Article in journal (Refereed)
    Abstract [en]

    Not only T cells but also B cells play a role in the autoimmune process. Both monoclonal antiCD3 and antiCD20 antibodies seem efficacious. However, such treatments need to be refined to minimize adverse events. Use of autoantigens to create tolerance is a concept with great potential. GAD65 treatment has shown efficacy without adverse events thus far, and administration of the insulin B chain shows interesting immunologic effects. Other more or less speculative approaches to modulate the immune process need further studies with good design. Risks that are too serious cannot be motivated. In addition, as the beta cells may die even though the autoimmune process is stopped, protective measures may be valuable (eg, active insulin treatment, and perhaps interleukin-1 receptor antagonists to reduce the nonautoimmune inflammation). Combination of immune intervention, protection of the beta cells, and stimulation of regeneration may lead to a milder disease or even a cure in the future, and prevention is no longer unrealistic.

  • 2. Westermark, Per
    et al.
    Andersson, Arne
    Westermark, Gunilla
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
    Is aggregate IAPP a cause of beta-cell failure in transplanted human pancreatic islets?2005In: Current Diabetes Reports, ISSN 1534-4827, E-ISSN 1539-0829, Vol. 5, no 3, p. 184-188Article in journal (Refereed)
    Abstract [en]

    Aggregation of the β-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the β-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on β cells that die, leading to reduced β-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased β-cell death and reduced β-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further. Copyright © 2005 by Current Science Inc.

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