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  • 1. Arbring, K
    et al.
    Nelson, Nina
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
    Cortisol response to heelstick stressor in preterm infants2000In: Prenatal and Neonatal Medicine, ISSN 1359-8635, E-ISSN 1473-0774, Vol. 5, no 3, p. 182-185Article in journal (Refereed)
    Abstract [en]

    To evaluate the hormonal response to stress in healthy preterm infants, we measured concentrations of serum cortisol at baseline and after capillary heelstick. Eleven preterm infants, five girls and six boys, with gestational ages ranging from 30 to 34 weeks, were studied. We measured the serum cortisol concentration before and 30 min after capillary heelstick on days 1, 3 and 7 of life. On days 3 and 7, but not on day 1, the rise in cortisol was significant (p = 0.02 and 0.04, respectively). The reduced response on day 1 can probably be explained by the significantly higher baseline concentrations. We suggest that a test like this can be useful in evaluating the hormonal stress response in preterm as well as full-term infants.

  • 2.
    Bylund, Bengt
    et al.
    Västerviks sjukhus.
    Cervin, Torsten
    Finnström, Orvar
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences.
    Gäddlin, Per-Olof
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences.
    Leijon, Ingemar
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences.
    Mård, Selina
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Educational Sciences.
    Samuelsson, Stefan
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Educational Sciences.
    Sandstedt, Per
    Wärngård, Olof
    Very low birth weight children at 9 years:  School performance and behaviour in relation to risk factors2000In: Prenatal and Neonatal Medicine, ISSN 1359-8635, E-ISSN 1473-0774, Vol. 5, no 2, p. 124-133Article in journal (Refereed)
    Abstract [en]

    Objectives To investigate the school performance and behavior of very low-birth-weight children in comparison with controls, and relate the findings to risk factors.

    Methods All children with birth weight below 1501 g (VLBW) and normal birth weight (NBW) controls, born in the south-east region of Sweden during a 15-month period in 1987-88, were enrolled in a prospective follow-up study; 81 % (n = 70) and 82% (n = 72), respectively, were re-examined at the age of 9 years regarding growth, neurological status, neurofunctional classification and academic achievement tests (Raven's matrices, mathematics, vocabulary, reading ability). The need for special education at school was assessed and four behavioral problem scores were also assessed (hyperactivity, fine motor skills, gross motor skills, social skills). Children with known handicaps were not re-examined.

    Results VLBW children were shorter and lighter than controls, and differed from them with regard to neurological functional classification. As a group, they produced poorer results in all academic achievement tests except vocabulary, and also in two out of four behavioral subscales (hyperactivity and fine motor skills). When the comparison was restricted to children with normal Raven scores, almost all the differences disappeared. VLBW children had more reading difficulties but were less often than expected defined as dyslexic compared to NEW children.

  • 3.
    Nelson, Nina
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
    Nylander, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Neonatal ventricular hypertrophy without cardiac malformations: A retrospective evaluation of 17 infants2001In: Prenatal and Neonatal Medicine, ISSN 1359-8635, E-ISSN 1473-0774, Vol. 6, no 5, p. 318-322Article in journal (Refereed)
    Abstract [en]

    Cardiac hypertrophy in the neonatal period is usually associated with other congenital defects of the circulatory system. Isolated ventricular hypertrophy can be difficult to evaluate and manage. We present 17 neonates with increased ventricular wall thickness without congenital malformations according to echocardiography during the neonatal period. The echocardiographic findings were defined as either concentric or predominantly septal hypertrophy. Doppler signs of ventricular outflow obstruction were found in six babies. The material consisted of preterm infants with steroid-treated bronchopulmonary dysplasia, metabolic disorders, perinatal infections, hypertrophic cardiomyopathy and babies with no identified underlying disorder. Six out of 17 patients died before the age of 8 months: all three babies with hypertrophic cardiomyopathy, one with toxoplasmosis and two out of four infants with steroid-treated bronchopulmonary dysplasia. It was not possible to predict the outcome from the initial clinical examination or from the first echocardiographic investigation. Ventricular wall thickness and outflow obstruction may undergo significant and rapid changes, and thus we recommend repeated echocardiographic examinations.

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