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  • 1.
    Erlandsson, Helen
    et al.
    Karolinska Inst, Sweden.
    Qureshi, Abdul Rashid
    Linköping University, Department of Health, Medicine and Caring Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Scholz, Tim
    Uppsala Univ Hosp, Sweden.
    Lundgren, Torbjorn
    Karolinska Inst, Sweden.
    Bruchfeld, Annette
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Medicine Center, Department of Nephrology. Karolinska Inst, Sweden.
    Stenvinkel, Peter
    Karolinska Inst, Sweden.
    Wennberg, Lars
    Karolinska Inst, Sweden.
    Lindner, Per
    Univ Gothenburg, Sweden.
    Observational study of risk factors associated with clinical outcome among elderly kidney transplant recipients in Sweden - a decade of follow-up2021In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 34, no 11, p. 2363-2370Article in journal (Refereed)
    Abstract [en]

    Kidney transplantation (Ktx) in elderly has become increasingly accepted worldwide despite their higher burden of comorbidities. We investigated important risk factors affecting long-term patient and graft survival. We included all (n = 747) Ktx patients >60 years from 2000 to 2012 in Sweden. Patients were age-stratified, 60-64, 65-69 and >70 years. Follow-up time was up to 10 years (median 7.9 years, 75% percentile >10 years). Primary outcome was 10-year patient survival in age-stratified groups. Secondary outcomes were 5-year patient and graft survival in age-stratified groups and the impact of risk factors including Charlson comorbidity index (CCI) on patient and graft survival. Mortality was higher in patients >70 years, after 10 years (HR 1.94; 95% CI 1.24-3.04; P = 0.004). Males had a higher 10-year risk of death (HR 1.39; CI 95% 1.04-1.86; P = 0.024). Five-year patient survival did not differ between age groups. In multivariate Cox analysis (n = 500), hazard ratio for 10-year mortality was 4.6 in patients with CCI >= 7 vs. <4 (95% CI 2.42-8.62; P = 0.0001). Higher CCI identified ESKD patients with 4.6 times higher risk of death after Ktx. We suggest that this index should be used as a part of the preoperative evaluation in elderly.

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  • 2.
    Farris, Alton B.
    et al.
    Emory Univ, GA 30322 USA.
    Alexander, Mariam P.
    Mayo Clin, MN USA.
    Balis, Ulysses G. J.
    Univ Michigan, MI USA.
    Barisoni, Laura
    Duke Univ, NC USA.
    Boor, Peter
    Rhein Westfalische TH RWTH Aachen Univ Clin, Germany; RWTH Aachen Univ Clin, Germany.
    Bulow, Roman D.
    Rhein Westfalische TH RWTH Aachen Univ Clin, Germany.
    Cornell, Lynn D.
    Mayo Clin, MN USA.
    Demetris, Anthony J.
    Univ Pittsburgh, PA USA.
    Farkash, Evan
    Univ Michigan, MI USA.
    Hermsen, Meyke
    Radboud Univ Nijmegen, Netherlands.
    Hogan, Julien
    Emory Univ, GA 30322 USA; Univ Paris, France.
    Kain, Renate
    Med Univ Vienna, Austria.
    Kers, Jesper
    Univ Amsterdam, Netherlands; Leiden Univ, Netherlands.
    Kong, Jun
    Georgia State Univ, GA USA; Emory Univ, GA USA.
    Levenson, Richard M.
    Univ Calif Davis Hlth Syst, CA USA.
    Loupy, Alexandre
    Univ Paris, France.
    Naesens, Maarten
    Katholieke Univ Leuven, Belgium.
    Sarder, Pinaki
    Univ Florida Gainesville, FL USA.
    Tomaszewski, John E.
    SUNY Buffalo, NY USA.
    van der Laak, Jeroen
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology. Linköping University, Center for Medical Image Science and Visualization (CMIV). Radboud Univ Nijmegen, Netherlands.
    van Midden, Dominique
    Radboud Univ Nijmegen, Netherlands.
    Yagi, Yukako
    Mem Sloan Kettering Canc Ctr, NY USA.
    Solez, Kim
    Univ Alberta, Canada.
    Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments2023In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 36, article id 11783Article in journal (Refereed)
    Abstract [en]

    The Banff Digital Pathology Working Group (DPWG) was established with the goal to establish a digital pathology repository; develop, validate, and share models for image analysis; and foster collaborations using regular videoconferencing. During the calls, a variety of artificial intelligence (AI)-based support systems for transplantation pathology were presented. Potential collaborations in a competition/trial on AI applied to kidney transplant specimens, including the DIAGGRAFT challenge (staining of biopsies at multiple institutions, pathologists visual assessment, and development and validation of new and pre-existing Banff scoring algorithms), were also discussed. To determine the next steps, a survey was conducted, primarily focusing on the feasibility of establishing a digital pathology repository and identifying potential hosts. Sixteen of the 35 respondents (46%) had access to a server hosting a digital pathology repository, with 2 respondents that could serve as a potential host at no cost to the DPWG. The 16 digital pathology repositories collected specimens from various organs, with the largest constituent being kidney (n = 12,870 specimens). A DPWG pilot digital pathology repository was established, and there are plans for a competition/trial with the DIAGGRAFT project. Utilizing existing resources and previously established models, the Banff DPWG is establishing new resources for the Banff community.

  • 3.
    Gullestad, Lars
    et al.
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research, University of Oslo, Oslo, Norway.
    Eiskjaer, Hans
    Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
    Gustafsson, Finn
    Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
    Riise, Gerdt C
    Department of Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Karason, Kristjan
    Department of Cardiology and Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Dellgren, Göran
    Department of Cardiology and Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Rådegran, Göran
    Department of Clinical Sciences Lund, Cardiology, Lund University and the Section for Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden.
    Hansson, Lennart
    Department of Respiratory Medicine, Lund University Hospital and Skåne University Hospital, Lund, Sweden.
    Gude, Einar
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research, University of Oslo, Oslo, Norway.
    Bjørtuft, Øystein
    Department of Respiratory Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
    Jansson, Kjell
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
    Schultz, Hans Henrik
    Division of Lung Transplantation, Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
    Solbu, Dag
    Novartis Norge AS, Oslo, Norway.
    Iversen, Martin
    Division of Lung Transplantation, Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
    Long-term outcomes of thoracic transplant recipients following conversion to everolimus with reduced calcineurin inhibitor in a multicenter, open-label, randomized trial2016In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 29, no 7, p. 819-829Article in journal (Refereed)
    Abstract [en]

    The NOCTET study randomized 282 patients ≥1 year after heart or lung transplantation to continue conventional calcineurin inhibitor (CNI) therapy or to start everolimus with reduced-exposure CNI. Last follow-up, at ≥5 years postrandomization (mean: 5.6 years) was attended by 72/140 everolimus patients (51.4%) and 91/142 controls (64.1%). Mean measured GFR remained stable in the everolimus group from randomization (51.3 ml/min) to last visit (51.4 ml/min) but decreased in controls (from 50.5 ml/min to 45.3 ml/min) and was significantly higher with everolimus at last follow-up (P = 0.004). The least squares mean (SE) change from randomization was -1.5 (1.7)ml/min with everolimus versus -7.2 (1.7)ml/min for controls (difference: 5.7 [95% CI 1.7; 9.6]ml/min; P = 0.006). The difference was accounted for by heart transplant patients (difference: 6.9 [95% 2.3; 11.5]ml/min; P = 0.004). Lung transplant patients showed no between-group difference at last follow-up. Rates of rejection, death, and major cardiac events were similar between groups, as was graft function. Pneumonia was more frequent with everolimus (18.3% vs. 6.4%). In conclusion, introducing everolimus in maintenance heart transplant patients, with reduced CNI, achieves a significant improvement in renal function which is maintained for at least 5 years, but an early renal benefit in lung transplant patients was lost. Long-term immunosuppressive efficacy was maintained.

  • 4. Nowak, G
    et al.
    Westermark, P
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Molecular and Immunological Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Wernerson, A
    Herlenius, G
    Sletten, K
    Ericzon, BG
    Liver transplantation as rescue treatment in a patient with primary AL kappa.2000In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 13, p. 92-97Article in journal (Refereed)
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