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  • 1.
    Gullestad, Lars
    et al.
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research, University of Oslo, Oslo, Norway.
    Eiskjaer, Hans
    Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
    Gustafsson, Finn
    Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
    Riise, Gerdt C
    Department of Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Karason, Kristjan
    Department of Cardiology and Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Dellgren, Göran
    Department of Cardiology and Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Rådegran, Göran
    Department of Clinical Sciences Lund, Cardiology, Lund University and the Section for Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden.
    Hansson, Lennart
    Department of Respiratory Medicine, Lund University Hospital and Skåne University Hospital, Lund, Sweden.
    Gude, Einar
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research, University of Oslo, Oslo, Norway.
    Bjørtuft, Øystein
    Department of Respiratory Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
    Jansson, Kjell
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
    Schultz, Hans Henrik
    Division of Lung Transplantation, Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
    Solbu, Dag
    Novartis Norge AS, Oslo, Norway.
    Iversen, Martin
    Division of Lung Transplantation, Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
    Long-term outcomes of thoracic transplant recipients following conversion to everolimus with reduced calcineurin inhibitor in a multicenter, open-label, randomized trial2016In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 29, no 7, 819-829 p.Article in journal (Refereed)
    Abstract [en]

    The NOCTET study randomized 282 patients ≥1 year after heart or lung transplantation to continue conventional calcineurin inhibitor (CNI) therapy or to start everolimus with reduced-exposure CNI. Last follow-up, at ≥5 years postrandomization (mean: 5.6 years) was attended by 72/140 everolimus patients (51.4%) and 91/142 controls (64.1%). Mean measured GFR remained stable in the everolimus group from randomization (51.3 ml/min) to last visit (51.4 ml/min) but decreased in controls (from 50.5 ml/min to 45.3 ml/min) and was significantly higher with everolimus at last follow-up (P = 0.004). The least squares mean (SE) change from randomization was -1.5 (1.7)ml/min with everolimus versus -7.2 (1.7)ml/min for controls (difference: 5.7 [95% CI 1.7; 9.6]ml/min; P = 0.006). The difference was accounted for by heart transplant patients (difference: 6.9 [95% 2.3; 11.5]ml/min; P = 0.004). Lung transplant patients showed no between-group difference at last follow-up. Rates of rejection, death, and major cardiac events were similar between groups, as was graft function. Pneumonia was more frequent with everolimus (18.3% vs. 6.4%). In conclusion, introducing everolimus in maintenance heart transplant patients, with reduced CNI, achieves a significant improvement in renal function which is maintained for at least 5 years, but an early renal benefit in lung transplant patients was lost. Long-term immunosuppressive efficacy was maintained.

  • 2. Nowak, G
    et al.
    Westermark, P
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Molecular and Immunological Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Wernerson, A
    Herlenius, G
    Sletten, K
    Ericzon, BG
    Liver transplantation as rescue treatment in a patient with primary AL kappa.2000In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 13, 92-97 p.Article in journal (Refereed)
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