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  • 1.
    Börjesson, L.
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Stockhaus, J.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Gauffin, Helena
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Ragnehed, Mattias
    Linköping University, Department of Medicine and Care, Medical Radiology. Linköping University, Faculty of Health Sciences.
    Lundberg, Peter
    Linköping University, Department of Medicine and Care, Radiation Physics. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Söderfeldt, Birgitta
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Comparison between fMRI and Wada test2004In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, Vol. 45, no Suppl. 3, p. 84-84Article in journal (Refereed)
    Abstract [en]

    Purpose: Language lateralisation in patients with epilepsy is more often atypical compared to a normal population. The Wada procedure for testing language and memory has some shortcomings; it is invasive and there is always a risk that the patient becomes too sedated, leading to difficulties in performing the tests. fMR1have shown promising results, showing good correlation to the Wadaprocedure concerning language-lateralisation. The aim of this studywas to investigate if fMRI could be used to determine which hemisphere was language dominant and compare the fMR1 results with the Wada-tests with a focus on patients with a complicated lateralisation.

    Method: 4 subjects were tested and they had a heterogeneous (I left handed, I ambidexter and 2 right handed) lateralisation and one had a severe dyslexia. A standard Wada procedure was used and compared with a fMRl investigation using a language paradigm.

    Results: The patients studied showed different language lateralisation patterns (2 left hemisphere and 2 bilateral). In two patients the two tests were fully concordant, in the others the fMRI showed a more bilateral pattern.

    Conclusion: fMR1 adds valuable information in the pre-surgical investigation for patients with a complex language lateralisation.

  • 2. Caceres, R
    et al.
    Leerbeck, K
    Landtblom, Anne-Marie
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Cardiac symptoms in epilepsy: Monitoring strategies2005In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, Vol. 6, p. 889-889Article in journal (Other academic)
  • 3.
    Klatt, Juliane
    et al.
    University of Freiburg, Germany.
    Feldwisch-Drentrup, Hinnerk
    University of Freiburg, Germany.
    Ihle, Matthias
    University Hospital of Freiburg, Germany.
    Navarro, Vincent
    CHU Pitie-Salpetriere, Paris, France.
    Neufang, Markus
    University Hospital of Freiburg, Germany.
    Teixeira, Cesar
    University of Coimbra, Portugal .
    Adam, Claude
    CHU Pitie-Salpetriere, Paris, France.
    Valderrama, Mario
    University of Paris 06, France .
    Alvarado-Rojas, Catalina
    University of Paris 06, France .
    Witon, Adrien
    University of Paris 06, France .
    Le Van Quyen, Michel
    University of Paris 06, France .
    Sales, Francisco
    University of Coimbra, Portugal .
    Dourado, Antonio
    University of Coimbra, Portugal .
    Timmer, Jens
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Schulze-Bonhage, Andreas
    University Hospital of Freiburg, Germany.
    Schelter, Bjoern
    University of Freiburg, Germany.
    The EPILEPSIAE database: An extensive electroencephalography database of epilepsy patients2012In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, Vol. 53, no 9, p. 1669-1676Article in journal (Refereed)
    Abstract [en]

    From the very beginning the seizure prediction community faced problems concerning evaluation, standardization, and reproducibility of its studies. One of the main reasons for these shortcomings was the lack of access to high-quality long-term electroencephalography (EEG) data. In this article we present the EPILEPSIAE database, which was made publicly available in 2012. We illustrate its content and scope. The EPILEPSIAE database provides long-term EEG recordings of 275 patients as well as extensive metadata and standardized annotation of the data sets. It will adhere to the current standards in the field of prediction and facilitate reproducibility and comparison of those studies. Beyond seizure prediction, it may also be of considerable benefit for studies focusing on seizure detection, basic neurophysiology, and other fields.

  • 4.
    Landtblom, Anne-Marie
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    The "Sensed Presence": An epileptic aura with religious overtones2005In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, p. 1004-1004Article in journal (Other academic)
  • 5. Leerbeck, K
    et al.
    Caceres, R
    Landtblom, Anne-Marie
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Effect of antiepileptic drugs on blood levels of homocysteine2005In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, p. 845-845Article in journal (Other academic)
  • 6. Öhman, Inger
    et al.
    Vitols, S
    Luef, Gerhard
    Söderfeldt, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Tomson, Torbjörn
    Topiramate kinetics during delivery, lactation, and in the neonate: Preliminary observations2002In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, Vol. 43, no 10, p. 1157-1160Article in journal (Refereed)
    Abstract [en]

    Purpose: To study the pharmacokinetics of topiramate (TPM) during delivery, lactation, and in the neonate. Methods: TPM concentrations in plasma and breast milk were measured with fluorescence polarization immunoassay (FPIA) in five women with epilepsy treated with TPM during pregnancy and lactation. Blood samples were obtained at delivery from mothers, from the umbilical cord, and from the newborns on three occasions (24, 48, and 72 h) after delivery. Blood and breast milk also were collected from mothers 2 weeks, and 1 and 3 months postpartum. Blood samples also were drawn from the infants during breast-feeding. Three of the mother-infant pairs were studied both at delivery and during lactation, two contributed with data from delivery only. Results: The umbilical cord plasma/maternal plasma ratios were close to unity, suggesting extensive transplacental transfer of TPM. The mean milk/maternal plasma concentration ratio was 0.86 (range, 0.67-1.1) at 2-3 weeks after delivery. The milk/maternal plasma concentration ratios at sampling 1 and 3 months after delivery were similar (0.86 and 0.69, respectively). Two to 3 weeks after delivery, two of the breast-fed infants had detectable (>0.9 ╡M) concentrations of TPM, although below the limit of quantification (2.8 ╡M), and one had an undetectable concentration. Conclusions: Our limited data suggest free passage of TPM over the placenta and an extensive transfer into breast milk. Breast-fed infants had very low TPM concentrations, and no adverse effects were observed in the infants.

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