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  • 1.
    Slind Olsen, Renate
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Dept Lab Med, Sweden.
    Dimberg, Jan
    Jonkoping Univ, Sweden.
    Geffers, Robert
    Helmholtz Ctr Infect Res, Germany.
    Wågsäter, Dick
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten.
    Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer2019Inngår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, nr 2, s. 99-112Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-beta) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-beta signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.

  • 2.
    Wågsäter, Dick
    et al.
    Karolinska Institute, Stockholm, Sweden.
    Lofgren, Sture
    Ryhov County Hospital, Jönköping, Sweden.
    Zar, Niklas
    Ryhov County Hospital, Jönköping, Sweden.
    Hugander, Anders
    Ryhov County Hospital, Jönköping, Sweden.
    Dimberg, Jan
    University College of Health Sciences, Jönköping, Sweden.
    Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients2010Inngår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 28, nr 8, s. 872-877Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p less than .001) of PEDF in the CRC patient group (1.6 mu g/mL) than in of a healthy control group (3.6 mu g/mL). A single nucleotide polymorphism (rs1136287, Tgreater thanC) was screened. In the control group, the CC genotype showed 30% lower PEDF plasma levels compared with the TT genotype (p less than .01), whereas the CRC patients failed to show any association regarding these genotypes.

  • 3.
    Wågsäter, Dick
    et al.
    Karolinska Institute, Stockholm, Sweden.
    Mumtaz, Melad
    Al-Nahrain University, Baghdad, Iraq.
    Löfgren, Sture
    Ryhov County Hospital, Jönköping, Sweden .
    Hugander, Anders
    University College of Health Sciences, Jönköping, Sweden.
    Dimberg, Jan
    Ryhov County Hospital, Jönköping, Sweden .
    Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter −420C > G genotype2008Inngår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, nr 10, s. 1008-1014Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A single nucleotide polymorphism (SNP) -420Cgreater than G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420Cgreater than G resistin polymorphism is not a potential genetic susceptibility factor.

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