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  • 1.
    Wågsäter, Dick
    et al.
    University of Örebro, Sweden.
    Sirsjö, Allan
    University of Örebro, Sweden.
    Dimberg, Jan
    School of Health Sciences, Jönköping; Sweden.
    Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)2003In: Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, E-ISSN 1756-9966, Vol. 22, no 3, p. 471-475Article in journal (Refereed)
    Abstract [en]

    Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.

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