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  • 1.
    Gauffin, Fredrika
    et al.
    Karolinska University Hospital.
    Diffner, Eva
    Malmö University Hospital.
    Gustafsson, Bertil
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Nordgren, Ann
    Karolinska Institute.
    Gjorloff Wingren, Anette
    Malmö University Hospital.
    Sander, Birgitta
    Karolinska Institute.
    Liao Persson, Jenny
    Lund University.
    Gustafsson, Britt
    Karolinska Institute.
    Expresson of PTEN and SHP1, Ivestigated from Tissue Microarrays in Pediatric Acute Lymphoblastic, Leukemia2009In: Pediatric Hematology & Oncology, ISSN 0888-0018, E-ISSN 1521-0669, Vol. 26, no 1, p. 48-56Article in journal (Refereed)
    Abstract [en]

    PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.

  • 2. Gustafsson, Britt
    et al.
    Axelsson, Birgitta
    Gustafsson, Bertil
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Christensson, Birger
    Winiarski, Jacek
    MDM2 and p53 in childhood acute lymphoblastic leukemia: Higher expression in childhood leukemias with poor prognosis compared to long-term survivors2001In: Pediatric Hematology & Oncology, ISSN 0888-0018, E-ISSN 1521-0669, Vol. 18, p. 497-508Article in journal (Refereed)
1 - 2 of 2
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