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  • 1.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Swedish E Science Research Centre SeRC, Sweden.
    Lantz, Jonas
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Swedish E Science Research Centre SeRC, Sweden.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Swedish E Science Research Centre SeRC, Sweden.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Swedish E Science Research Centre SeRC, Sweden.
    Correction: Quantitative Assessment of Turbulence and Flow Eccentricity in an Aortic Coarctation: Impact of Virtual Interventions (vol 6, pg 281, 2015)2015Ingår i: Cardiovascular Engineering and Technology, ISSN 1869-408X, E-ISSN 1869-4098, Vol. 6, nr 4, s. 577-589Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Turbulence and flow eccentricity can be measured by magnetic resonance imaging (MRI) and may play an important role in the pathogenesis of numerous cardiovascular diseases. In the present study, we propose quantitative techniques to assess turbulent kinetic energy (TKE) and flow eccentricity that could assist in the evaluation and treatment of stenotic severities. These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. Patient-specific geometry and flow conditions were derived from MRI data. The unsteady pulsatile flow was resolved by large eddy simulation (LES) including non-Newtonian blood rheology. Results showed an inverse asymptotic relationship between the total amount of TKE and degree of dilatation of the stenosis, where the pre-stenotic hypoplastic segment may limit the possible improvement by treating the CoA alone. Spatiotem-poral maps of TKE and flow eccentricity could be linked to the characteristics of the post-stenotic jet, showing a versatile response between the CoA dilatations. By including these flow markers into a combined MRI-CFD intervention framework, CoA therapy has not only the possibility to produce predictions via simulation, but can also be validated pre-and immediate post treatment, as well as during follow-up studies.

  • 2.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Lantz, Jonas
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Multidirectional WSS disturbances in stenotic turbulent flows: A pre- and post-intervention study in an aortic coarctation2017Ingår i: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 51Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Wall shear stress (WSS) disturbances are commonly expressed at sites of abnormal flow obstructions and may play an essential role in the pathogenesis of various vascular diseases. In laminar flows these disturbances have recently been assessed by the transverse wall shear stress (transWSS), which accounts for the WSS multidirectionality. Site-specific estimations of WSS disturbances in pulsatile transitional and turbulent type of flows are more challenging due to continuous and unpredictable changes in WSS behavior. In these complex flow settings, the transWSS may serve as a more comprehensive descriptor for assessing WSS disturbances of general nature compared to commonly used parameters. In this study large eddy simulations (LES) were used to investigate the transWSS properties in flows subjected to different pathological turbulent flow conditions, governed by a patient-specific model of an aortic coarctation pre and post balloon angioplasty. Results showed that regions of strong near-wall turbulence were collocated with regions of elevated transWSS and turbulent WSS, while in more transitional-like near-wall flow regions a closer resemblance was found between transWSS and low, and oscillatory WSS. Within the frame of this study, the transWSS parameter demonstrated a more multi-featured picture of WSS disturbances when exposed to different types of flow regimes, characteristics which were not depicted by the other parameters alone. (C) 2016 Published by Elsevier Ltd.

  • 3.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Lantz, Jonas
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Quantitative Assessment of Turbulence and Flow Eccentricity in an Aortic Coarctation - Impact of Virtual Interventions2015Ingår i: Cardiovascular Engineering and Technology, ISSN 1869-408X, E-ISSN 1869-4098, Vol. 6, nr 6, s. 281-293Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Turbulence and flow eccentricity can be measured by magnetic resonance imaging (MRI) and may play an important role in the pathogenesis of numerous cardiovascular diseases. In the present study, we propose quantitative techniques to assess turbulent kinetic energy (TKE) and flow eccentricity that could assist in the evaluation and treatment of stenotic severities. These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. Patient-specific geometry and flow conditions were derived from MRI data. The unsteady pulsatile flow was resolved by large eddy simulation (LES) including non-Newtonian blood rheology. Results showed an inverse asymptotic relationship between the total amount of TKE and degree of dilatation of the stenosis, where turbulent flow proximal the constriction limits the possible improvement by treating the CoA alone. Spatiotemporal maps of TKE and flow eccentricity could be linked to the characteristics of the jet, where improved flow conditions were favored by an eccentric dilatation of the CoA. By including these flow markers into a combined MRI-CFD intervention framework, CoA therapy has not only the possibility to produce predictions via simulation, but can also be validated pre- and immediate post treatment, as well as during follow-up studies.

  • 4.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Lantz, Jonas
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Modeling of Subject Arterial Segments Using 3D Fluid Structure Interaction and 1D-0D Arterial Tree Network Boundary Condition2011Konferensbidrag (Refereegranskat)
    Abstract [en]

    Modeling of Subject Specific Arterial Segments Using 3D Fluid Structure Interaction and a 1D-0D Arterial Tree Network Boundary Condition

     

    Magnus Andersson, Jonas Lantz , Matts Karlsson

     

    Department of Management and Engineering, Linköping University, SE-581 83 Linköping, Sweden

     

    Introduction

    In recent years it has been possible to simulate 3D blood flow through CFD including the dilatation effect in elastic arteries using Fluid-Structure Interaction (FSI) to better match in vivo data. Patient specific imposed boundary condition (BC) is often used as the velocity profiles at the inlets. However, for the outlet BC a time-resolved pressure is required and often lacking as it is obtained by an invasive procedure. Numerous models have been developed for capturing the main effects of the vascular bed at these sites, which have been shown crucial and difficult to implement accurately. This work focus on a full scaled FSI simulation at an arterial section including the abdominal aorta, renal arteries and iliac bifurcations, obtained from MRI of an healthy individual. The outlet BC at the iliac arteries is connected with a 1D systemic arterial tree which is truncated with a 0D lumped model. This 3D-(0D-1D) connection can provide the essential features of the peripheral flow and, in contrast to the imposed BC, the 1D-0D coupling allow for investigation of cardiovascular diseases including stenoses and/or hypertension.

     

    Methods

    The MRI images were segmented using an in-house software to obtain a 3D surface of the vessel lumen, Figure 1. The surfaces were meshed with high quality hexahedral element using ANSYS ICEM CFD 12.0 (ANSYS Inc, Canonsburg, PA, USA). A PC-MRI time-resolved massflow at the descending aorta were used as inlet BC, where 22% of the flow was forced into the renal bifurcations assuming negligible pressure wave reflection. The wall was modelled with an isotropic elastic model with addition of an elastic support mimicking the damping effect of the surrounding tissue. The 1D model is based on transmission-line theory which involves an impedance model for the pressure-flow relationship. The arterial topology was extracted from literature and only the central arteries after the iliacs was considered. At the truncation sites a 3-element Windkessel model (known as RRC) was implemented and is the most common model of choice for describing the main effects of all the distal vessels.  The 1D system solves the Fourier frequency impedance coefficients over one heart cycle accounting for wave reflection by using the 15 first harmonics to obtain the corresponding pressure. The 3D-1D connection is done offline, which allows for an independent and more stable 3D simulation. This step is iteratively repeated until convergence is reach between the present 3D outlet flow and previous implemented 1D outlet flow. The simulation was utilized in ANSYS CFX, ANSYS Mechanical, and coupled by ANSYS Multi-Field.

     

    Results

    The (0D-1D)-3D model showed convergence of pressure/flow at the iliac outlets, Figure 2. The method provides realistic pressure and flow responses based on the input parameters and even capture the relative difference in flow/pressure distribution between the right and left illiac artery due to subject specific geometric variability. Parameters such as velocity profiles and WSS can be extracted in the 3D domain.

     

    Conclusions

    This method allows for a better insight of large scale vascular networks effect of the local 3D flow features and also gives a better representation of the peripheral flow compared to a pure 0D (lumped parameter/Windkessel) model. PC-MRI will provide data for validation of velocity profiles in the 3D model. Future work includes a subject specific 1D vascular topology to be combined with the 3D model.   

  • 5.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Lantz, Jonas
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska högskolan.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    NON-INVASIVE INTERVENTION PLANNING OF STENOTIC FLOWS USING SCALE-RESOLVED IMAGE-BASED COMPUTATIONAL FLUID DYNAMICS2013Konferensbidrag (Refereegranskat)
  • 6.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Lantz, Jonas
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska högskolan.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Turbulence Quantification of Stenotic Blood Flow Using Image-Based CFD: Effect of Different Interventions2014Ingår i: WCB 2014, 2014Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    Turbulent blood flow is often associated with some sort of cardiovascular disease, e.g. sharp bends and/or sudden constrictions/expansions of the vessel wall. The energy losses associated with the turbulent flow may increase the heart workload in order to maintain cardiac output (CO). In the present study, the amount of turbulent kinetic energy (TKE) developed in the vicinity of an aortic coarctation was estimated pre-intervention and in a variety of post-intervention configurations, using scale-resolved image-based computational fluid dynamics (CFD). TKE can be measured using magnet resonance imaging (MRI) and have also been validated with CFD simulations [1], i.e. a parameter that not only can be quantified using simulations but can also be measured by MRI.

    Patient-specific geometry and inlet flow conditions were obtained using contrast-enhanced MR angiography and 2D cine phase-contrast MRI, respectively. The intervention procedure was mimicked using an inflation simulation, where six different geometries were obtained. A scale-resolving turbulence model, large eddy simulation (LES), was utilized to resolve the largest turbulent scales and also to capture the laminar-to-turbulent transition. All cases were simulated using baseline CO and with a 20% CO increase to simulate a possible flow adaption after intervention.

    For this patient, results shows a non-linear decay of the total amount of TKE integrated over the cardiac phase as the stenotic cross-sectional area is increased by the intervention.  Figure 1 shows the original segmented geometry and two dilated coarctation with corresponding volume rendering of the TKE at peak systole. Due to turbulent transition at a kink upstream the stenosis further dilation of the coarctation tends to restrict the TKE to a plateau, and continued vessel expansion may therefore only induce unnecessary stresses onto the arterial wall. 

    This patient-specific non-invasive framework has shown the geometrical impact on the TKE estimates. New insight in turbulence development indicates that the studied coarctation can only be improved to a certain extent, where focus should be on the upstream region, if further TKE reduction is motivated. The possibility of including MRI in a combined framework could have great potential for future intervention planning and follow-up studies.  

    [1] J. Lantz, T. Ebbers, J. Engvall and M. Karlsson, Numerical and Experimental Assessment of Turbulent Kinetic Energy in an Aortic Coarctation, Journal of Biomechnics, 2013. 46(11): p. 1851-1858.

  • 7.
    Andersson, Magnus
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Nadali Najafabadi, Hossein
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Wren, Joakim
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Improving Written Communcation Skills in Engineering Programs2016Ingår i: Proceedings of the International CDIO Conference, 2016, artikel-id 225Konferensbidrag (Refereegranskat)
    Abstract [en]

    This study focuses on the improvement of students’ written communication skill in highereducation, aiming at higher quality of reports at different course levels. Towards this aim, twosupportive guideline documents, “report structure” and “report format”, have been writtenaligned with the courses’ syllabi and introduced as complementary material.

  • 8. Andersson, R
    et al.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Pressure sensed non-invasively directly on the extra corporeal bloodline tube2001Ingår i: PROCEEDINGS OF THE 23RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: BUILDING NEW BRIDGES AT THE FRONTIERS OF ENGINEERING AND MEDICINE, 2001, Vol. 23, s. 3179-3181Konferensbidrag (Refereegranskat)
    Abstract [en]

    To clinically measure blood pressure at extra corporeal bloodlines involves a hazard due to the infection risk and a risk for thrombosis formation. The aim was to design a non-invasive pressure sensor, measuring directly on a tube section. A modified tube cross-section was used to improve sensitivity. Using the developed sensing principle, a consistent relation (r=0.999) was obtained between pressure and output signal. The output was stable and an acceptable drift within the temperature-range. The method shows great promise for applications in monitoring of the dialysis process.

  • 9.
    Aneq Åström, Meriam
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Nylander, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Determination of right ventricular volume and function using multiple axially rotated MRI slices2011Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 31, nr 3, s. 233-239Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Pandgt;Background: The conventional magnetic resonance imaging (MRI) method for right ventricular (RV) volume and motion, using short-axis (SA) orientation, is limited by RV anatomy and shape. We suggest an orientation based on six slices rotated around the long axis of the RV, rotated long axis (RLA). Materials and methods: Three phantoms were investigated in SA and RLA using cine balanced steady-state free precession MRI. Volumes were calculated based on segmentation and checked against true volumes. In 23 healthy male volunteers, we used six long-axis planes from the middle of the tricuspid valve to the RV apex, rotated in 30 degrees increments. For comparison, short-axis slices were acquired. Imaging parameters were identical in both acquisitions. Results: Right ventricular end-diastolic (EDV), end-systolic (ESV) and stroke volumes (SV) determined in the RLA 179 center dot 1 +/- 29 center dot 3; 80 center dot 1 +/- 17 center dot 1; 99 center dot 3 +/- 16 center dot 9 ml and in the SA were 174 center dot 0 +/- 21 center dot 1; 78 center dot 8 +/- 13 center dot 6; 95 center dot 3 +/- 14 center dot 5 ml with P-values for the difference from 0 center dot 17 to 0 center dot 64 (ns). Interobserver variability ranged between 3 center dot 2% and 6 center dot 6% and intraobserver variability between 2 center dot 8% and 6 center dot 8%. In SA views, consensus for the definition of the basal slice was necessary in 39% of the volunteers for whom the average volume change was 20% in ESV and 10% in EDV. Conclusions: The RLA method results in better visualization and definition of the RV inflow, outflow and apex. Accurate measurement of RV volumes for diagnosis and follow-up of cardiac diseases are enhanced by the RLA orientation, even though additional acquisition time is required.

  • 10.
    Ask, Per
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    ENGVALL, J
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    THEORETICAL AND EXPERIMENTAL-ANALYSIS OF AORTIC COARCTATION1989Ingår i: IMAGES OF THE TWENTY-FIRST CENTURY, PTS 1-6, 1989, Vol. 11, s. 103-103Konferensbidrag (Refereegranskat)
    Abstract [en]

    Aortic coarctation, which could severely influence the haemodynamic conditions of the body, is discussed. A theory has been developed which relates the pressure drop over the coarctation to the flow. This theory indicates that the pressure drop across the actual coarctation is related to the flow squared. For the collateral flow the expected pressure drop is either linearly or quadratically related to the flow. Model experiments and patient data support the present theoretical model

  • 11.
    Ask, Per
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Hök, B
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Teriö, H
    Bio-acoustic signals from stenotic tube flow: state of the art and perspectives for future methodological development.1995Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 33, nr 5, s. 669-675Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    To study the degree of stenosis from the acoustic signal generated by the turbulent flow in a stenotic vessel, so-called phonoangiography was first suggested over 20 years ago. A reason for the limited use of the technique today may be that, in the early work, the theory of how to relate the spectrum of the acoustic signal to the degree of the stenosis was not clear. However, during the last decade, the theoretical basis for this and other biological tube flow applications has been clarified. Now there is also easy access to computers for frequency analysis. A further explanation for the limited diagnostic use of bio-acoustic techniques for tube flow is the strong competition from ultrasound Doppler techniques. In the future, however, applications may be expected in biological tube flow where the non-invasive, simple and inexpensive bio-acoustic techniques will have a definite role as a diagnostic method.

  • 12.
    Ask, Per
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Regurgitant flow through heart valves: a hydraulic model applicable to ultrasound Doppler measurements.1986Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 24, nr 6, s. 643-646Artikel i tidskrift (Refereegranskat)
  • 13. Barclay, Susan A
    et al.
    Eidenvall, Lars
    Karlsson, Matts
    Andersson, Gunnar
    Xiong, Changsheng
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    The shape of the proximal isovelocity surface area varies with regurgitant orifice size and distance from orifice: computer simulation and model experiments with color M-mode technique.1993Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 6, nr 4, s. 433-445Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The hemispheric proximal isovelocity surface area method for quantification of mitral regurgitant flow (i.e., Qc = 2 pi r2v), where 2 pi r2 is the surface area and v is the velocity at radius r, was investigated as distance from the orifice was increased. Computer simulations and steady flow model experiments were performed for orifices of 4, 6, and 8 mm. Flow rates derived from the centerline velocity and hemispheric assumption were compared with true flow rates. Proximal isovelocity surface area shape varied as distance from each orifice was increased and could only be approximated from the hemispheric equation when a certain distance was exceeded: > 7, > 10, and > 12 mm for the 4, 6, and 8 mm orifices, respectively. Prediction of relative error showed that the best radial zone at which to make measurements was 5 to 9, 6 to 14 and 7 to 17 mm for the 4, 6, and 8 mm orifices, respectively. Although effects of a nonhemispheric shape could be compensated for by use of a correction factor, a radius of 8 to 9 mm can be recommended without the use of a correction factor over all orifices studied if a deviation in calculated as compared with true flow of 15% is considered acceptable. These measurements therefore have implications for the technique in clinical practice.

  • 14.
    Bech-Hanssen, O.
    et al.
    Department of Clinical Physiology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
    Gjertsson, P.
    Gjertsson, P..
    Houltz, E.
    Department of Clinical Physiology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
    Wranne, Bengt
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Caidahl, K.
    Caidahl, K..
    Net Pressure Gradients in Aortic Prosthetic Valves can be Estimated by Doppler2003Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 16, nr 8, s. 858-866Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: In aortic prosthetic valves, both the Doppler-estimated gradients and orifice areas are misleading in the assessment of hemodynamic performance. The parameter of major interest is the net pressure gradient after pressure recovery (PR). We, therefore, investigated, in vitro, our ability to predict the net pressure gradient and applied the formulas in a representative patient population with 2 different valve designs. Methods: We studied the St Jude Medical (SJM) standard valve (size 19-27) and SJM Biocor (size 21-27) in an in vitro steady-flow model with simultaneous Doppler-estimated pressure and catheter pressure measurements. Using echocardiography, we also studied patients who received the SJM (n = 66) and SJM Biocor (n = 45). Results: In the SJM, we observed PR both within the prosthesis and aorta, whereas in the SJM Biocor, PR was only present in the aorta. We estimated the PR within the valve and within the aorta separately from echocardiographic in vitro data, combining a regression equation (valve) with an equation on the basis of fluid mechanics theory (aorta). The difference between estimated and catheter-obtained net gradients (mean ± SD) was 0.6 ± 1.6 mm Hg in the SJM and - 0.2 ± 1.9 mm Hg in the SJM Biocor. When these equations were applied in vivo, we found that PR had an overall value of 57 ± 7% of the peak Doppler gradient in the SJM and 33 ± 9% in the SJM Biocor. Conclusions: The in vitro results indicate that it is possible to predict the net pressure gradient by Doppler in bileaflet and stented biologic valves. Our data indicate that important PR is also present in stented biologic valves.

  • 15.
    Berglund, Martina
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Logistik- och kvalitetsutveckling. Linköpings universitet, Tekniska fakulteten.
    Andersson, Torbjörn
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Maskinkonstruktion. Linköpings universitet, Tekniska fakulteten.
    Hedbrant, Johan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Pavlasevic, Vanja
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Maskinkonstruktion. Linköpings universitet, Tekniska fakulteten.
    Stålhand, Jonas
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanik och hållfasthetslära. Linköpings universitet, Tekniska fakulteten.
    Understanding the user beyond ‘common sense’ – teaching Product Ergonomics to design engineering students2015Ingår i: Proceedings 19th Triennial Congress of the IEA, International Ergonomics Association , 2015Konferensbidrag (Refereegranskat)
    Abstract [en]

    Multidisciplinary frameworks are needed to develop products that fit the human. Ergonomics is a multifaceted field that encompasses physical, cognitive and organizational aspects, and it is therefore a suitable subject to be taught to design engineering students.

    The objective of this paper was to describe and reflect upon how a systems perspective on Ergonomics is developed and conveyed in a course in Product Ergonomics to engineering students at the Design and Product Development (DPD) programme at Linköping University, Sweden. The paper is based on the authors’ experiences from teaching the course in Product Ergonomicsas well ason 52 students’ written reflections about their view on Ergonomics before and after taking the course.

    Means and ideas for teaching Ergonomics with a systems perspective included organizing a theoretical introduction into weekly themes and thereafter integrating and applying these themes in a product concept project under supervision of a multidisciplinary teacher team.

    The paper also reflects on how the systems perspective of Ergonomics is planned for and realized in the intended, implemented and attained curriculum.

  • 16.
    Berglund, Martina
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Logistik- och kvalitetsutveckling. Linköpings universitet, Tekniska fakulteten.
    Pavlasevic, Vanja
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Maskinkonstruktion. Linköpings universitet, Tekniska fakulteten.
    Andersson, Torbjörn
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Maskinkonstruktion. Linköpings universitet, Tekniska fakulteten.
    Hedbrant, Johan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Stålhand, Jonas
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanik och hållfasthetslära. Linköpings universitet, Tekniska fakulteten.
    Theme-based assessment of education in design and product development2014Ingår i: Proceedings of the 10th International CDIO Conference, Universitat Politècnica de Catalunya, 2014Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    One fundamental challenge in choosing an examination form to assess student achievements is to find an examination which, both encourages students to continuously elaborate the course content and constitutes a learning process itself. The objective of this paper is to share and reflect on the development and implementation of a new theme-based examination in a six credit course in Product Ergonomics given in the engineering programme Design and Product Development at Linköping University, Sweden. The course runs during four months and has two parts: one theoretical and one applied. The former focuses on theoretical ergonomic topics, models and methods while the latter is a project aiming at consolidating the students’ understanding of the theory by implementing the knowledge in a product development case. To encourage the students to adapt a deep learning approach, the traditional written mid-term exam for the theoretical part was abandoned and another concept developed. In the new concept, the theoretical part was split onto six weekly themes. Each theme was introduced at the beginning of the week by high-lighting main theories and models followed by a group-work assignment to be elaborated on by the students during the week. The theme was examined at the end of the week through a short written exam and a seminar to discuss and reflect upon the theme. From a student perspective, the positive outcome of the theme-based examination was peer learning and a more active learning style. The students appreciated the theme-based structure of the course. Occasionally, some students commented that weekly examinations could be perceived as stressful. The teachers perceived the students to be more acquainted with ergonomics theory and methods which increased the quality of the course project. The reported theme-based assessment is one example of implementing among others the CDIO syllabus parts 2.2 and 3.1and CDIO standards 8 and 11.

  • 17.
    Berntsson, Fredrik
    et al.
    Linköpings universitet, Matematiska institutionen, Beräkningsmatematik. Linköpings universitet, Tekniska fakulteten.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Kozlov, Vladimir
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Nazarov, Sergei A.
    St Petersburg State University, Russia; St Petersburg State Polytech University, Russia.
    A Modification to the Kirchhoff Conditions at a Bifurcation and Loss Coefficients2018Rapport (Övrigt vetenskapligt)
    Abstract [en]

    One dimensional models for fluid flow in tubes are frequently used tomodel complex systems, such as the arterial tree where a large numberof vessels are linked together at bifurcations. At the junctions transmission conditions are needed. One popular option is the classic Kirchhoffconditions which means conservation of mass at the bifurcation andprescribes a continuous pressure at the joint.

    In reality the boundary layer phenomena predicts fast local changesto both velocity and pressure inside the bifurcation. Thus it is not appropriate for a one dimensional model to assume a continuous pressure. In this work we present a modification to the classic Kirchhoff condi-tions, with a symmetric pressure drop matrix, that is more suitable forone dimensional flow models. An asymptotic analysis, that has beencarried out previously shows that the new transmission conditions hasen exponentially small error.

    The modified transmission conditions take the geometry of the bifurcation into account and can treat two outlets differently. The conditions can also be written in a form that is suitable for implementationin a finite difference solver. Also, by appropriate choice of the pressuredrop matrix we show that the new transmission conditions can producehead loss coefficients similar to experimentally obtained ones.

  • 18.
    Berntsson, Fredrik
    et al.
    Linköpings universitet, Matematiska institutionen, Beräkningsmatematik. Linköpings universitet, Tekniska fakulteten.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Kozlov, Vladimir
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Nazarov, Sergey A.
    St Petersburg State University, St Petersburg State Polytechnical University, and Institute of Problems of Mechanical Engineering RAS, Russia..
    A one-dimensional model of a false aneurysm2017Ingår i: International Journal of Research in Engineering and Science (IJRES), ISSN 2320-9356, Vol. 5, nr 6, s. 61-73Artikel i tidskrift (Refereegranskat)
    Abstract [en]

     A false aneurysm is a hematoma, i.e. collection ofblood outside of a blood vessel, that forms due to a hole  in the wall of an artery . This represents a serious medical condition that needs to be monitored and, under certain conditions, treatedurgently. In this work a one-dimensional model of a false aneurysm isproposed. The new model is based on a one-dimensional model of anartery previously presented by the authors and it takes into accountthe interaction between the hematoma  and the surrounding musclematerial. The model equations are derived  using rigorous asymptoticanalysis for the case of a simplified geometry.   Even though the model is simple it still supports a realisticbehavior for the system consisting of the vessel and the  hematoma. Using numerical simulations we illustrate the behavior ofthe model. We also investigate the effect  of changing the size of the hematoma. The simulations show that ourmodel can reproduce realistic solutions. For instance we show thetypical strong pulsation of an aneurysm by blood entering the hematoma during the work phase of the cardiac cycle, and the blood returning tothe vessel during the resting phase. Also we show that the aneurysmgrows  if the pulse rate is increased due to, e.g., a higher work load. 

  • 19.
    Berntsson, Fredrik
    et al.
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Kozlov, Vladimir
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Nazarov, Sergey A.
    St Petersburg State University, Russia; St Petersburg State Polytech University, Russia; RAS, Russia.
    A one-dimensional model of viscous blood flow in an elastic vessel2016Ingår i: Applied Mathematics and Computation, ISSN 0096-3003, E-ISSN 1873-5649, Vol. 274, s. 125-132Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this paper we present a one-dimensional model of blood flow in a vessel segment with an elastic wall consisting of several anisotropic layers. The model involves two variables: the radial displacement of the vessels wall and the pressure, and consists of two coupled equations of parabolic and hyperbolic type. Numerical simulations on a straight segment of a blood vessel demonstrate that the model can produce realistic flow fields that may appear under normal conditions in healthy blood vessels; as well as flow that could appear during abnormal conditions. In particular we show that weakening of the elastic properties of the wall may provoke a reverse blood flow in the vessel. (C) 2015 Elsevier Inc. All rights reserved.

  • 20.
    Biju, Dona
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    A parametric study of oil-jet lubrication in gear wheels2018Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    A parametric study of oil-jet lubrication in gear wheels is conducted using Computational Fluid Dynamics (CFD) to study the effect of the different design parameters on the cooling performance in a gearbox. Flow in oil jet lubrication is found to be complex with the formation of oil ligaments and droplets. Various hole radii of 1.5, 2 and 2.5 mm along with five oil velocities is analyzed and it is found that at lower volumetric rates, velocity has more effect on the cooling and at higher volumetric rates, hole size has more effect on the cooling. At higher velocities, the heat transfer is much greater than the actual heat production in the gear wheel, hence these velocity ratios are considered less suitable for jet lubrication. At low velocity ratios of below 2, the oil doesn’t fully impinge the gear bottom land and the sides leading to low cooling. Based on the cooling, impingement length and amount of oil lost to the casing surface, 2 mm hole with a velocity ratio of 2.225 is selected for a successful oil jet lubrication. Varying the inlet position in X, Y and Z directions (horizontal, vertical and lateral respectively) is found to have no improvement on the cooling. Making the oil jet hit the gear wheel surface at an angle is found to increase the cooling. Analysis with the use of a pipe to supply oil was conducted with circular and square inlet and it was found that the heat transfer decreases in both cases due to the splitting of oil jet caused by the combination of the effects of high pressure from the pipe and vorticity in the air field. A method has been developed for two gear analysis using overset meshes which can be used for further studies of jet lubrication in multi-gear systems. Single inlet is found to be better for cooling two gear wheels as it would require a reduced volumetric flow rate compared to double inlets. Oil system requirements for jet lubrication was studied and it was concluded that larger pumps have to be used to provide the high volumetric rates and highly pressurized oil required. On comparing the experimental losses from dip lubrication and the analytical losses for jet lubrication, dip lubrication is found to have lesser loses and more suitable for this case. Good quality lubrication would reduce the fuel consumption and also increase the longevity of gearboxes and hence more research into analyzing alternate lubrication systems can be carried out using the results from this thesis.

  • 21.
    Björck, Hanna M.
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet.
    Renner, Johan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Maleki, Shohreh
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Sweden.
    Nilsson, Siv F.E.
    Linköpings universitet, Institutionen för medicin och hälsa, Farmakologi. Linköpings universitet, Hälsouniversitetet.
    Kihlberg, Johan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Folkersen, Lasse
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Sweden.
    Karlsson, Matts
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Eriksson, Per
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Sweden.
    Länne, Toste
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Thorax-kärlkliniken i Östergötland.
    Characterization of Shear-Sensitive Genes in the NormalRat Aorta Identifies Hand2 as a Major Flow-ResponsiveTranscription Factor2012Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, nr 12Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: Shear forces play a key role in the maintenance of vessel wall integrity. Current understanding regarding shear-dependent gene expression is mainly based on in vitro or in vivo observations with experimentally deranged shear, hence reflecting acute molecular events in relation to flow. Our objective was to determine wall shear stress (WSS) in the rat aorta and study flow-dependent vessel wall biology under physiological conditions.

    Methods and Results: Animal-specific aortic WSS magnitude and vector direction were estimated using computational fluid dynamic simulation based on aortic geometry and flow information acquired by MRI. Two distinct flow pattern regions were identified in the normal rat aorta; the distal part of the inner curvature being exposed to low WSS and a non-uniform vector direction, and a region along the outer curvature being subjected to markedly higher levels of WSS and a uniform vector direction. Microarray analysis revealed a strong differential expression between the flow regions, particularly associated with transcriptional regulation. In particular, several genes related to Ca2+-signalling, inflammation, proliferation and oxidative stress were among the most highly differentially expressed.

    Conclusions: Microarray analysis validated the CFD-defined WSS regions in the rat aorta, and several novel flow-dependent genes were identified. The importance of these genes in relation to atherosusceptibility needs further investigation.

  • 22.
    Björe Dahl, Emilia
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Sjöqvist, Mikaela
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ökad resurseffektivitet i kraftvärmesystem genom säsongslagring av värme2014Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Att öka resurseffektiviteten i ett energisystem kan medföra stora ekonomiska och miljömässiga fördelar. Tekniska verken i Linköping AB (Tekniska verken) är ansvariga för Linköpings fjärrvärmeförsörjning. De har som vision att skapa världens mest resurseffektiva region. Ett viktigt steg på vägen för att nå detta är bättre utnyttjande av producerad värme, något som kan uppnås genom integrering av ett säsongsvärmelager i energisystemet. Syftet med detta examensarbete är därmed att utreda vilken ekonomisk och teknisk potential som finns för ett säsongsvärmelager i Tekniska verkens energisystem. Den lagerteknik som undersöks är borrhålslager med två typer av borrhålsvärmeväxlare; u-rör och ringformad koaxial borrhålsvärmeväxlare.

    För att utvärdera hur Tekniska verkens energisystem förändras vid integrering av ett säsongsvärmelager har en beräkningsmodell byggts upp i MATLAB. Två typer av värmepumpar har utvärderats i modellen; absorptionsvärmepumpar och kompressions­värmepumpar. Anledningen till detta är att den säsongslagrade värmen behöver uppgraderas för att kunna användas i ordinarie fjärrvärmenät. Den huvudsakliga metoden som använts vid beräkning av värmeöverföringsprocesser är finita differensmetoden. Vid ekonomiska beräkningar uttrycks investeringens ekonomiska potential enbart i relation till scenariot att lagret inte byggs.

    Fyra system med olika kombinationer av borrhålsvärmeväxlare och värmepumpar har simulerats över en tjugoårsperiod. De simulerade lagren har ett djup på 200-250 meter och en radie på cirka 100 meter vilket motsvarar ungefär 1500 borrhål. Resultatet påvisar små skillnader mellan de två typerna av borrhålsvärmeväxlare. Vilken typ av värmepump som används har dock en avgörande betydelse för det ekonomiska resultatet. Systemen med absorptionsvärmepumpar drivs av värme från befintlig ångproduktion och klarar av att täcka en större andel av topplasten vintertid. Samtidigt medför användning av kompressionsvärmepumpar en stor kostnad för drivel. Detta medför ett negativt nettonuvärde enligt examensarbetets resultat, medan systemen med absorptionsvärmepumpar har en diskonterad avbetalningstid på 12 år. Ytterligare en positiv effekt av systemen med absorptionsvärmepump är minskade utsläpp av koldioxid.

    Utifrån examensarbetets resultat framstår det som att genom integrering av ett borrhålslager med absorptionsvärmepumpar uppnås både ekonomiska vinster och en ökad resurseffektivitet i Tekniska verkens energisystem. Att fortsätta utreda denna potential framstår därmed som fördelaktigt. 

  • 23. Bolger, A F
    et al.
    Eidenvall, L
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Understanding continuous-wave Doppler signal intensity as a measure of regurgitant severity.1997Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 10, nr 6, s. 613-622Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Continuous-wave Doppler signal intensity is commonly expected to reflect the severity of mitral regurgitation. Physical principles predict that alignment of the imaging beam, flow velocity, and turbulence can also be important or even dominant determinants of continuous-wave Doppler signal intensity. The reliability of tracking regurgitant severity with continuous-wave Doppler signal intensity was assessed in vitro with varying volume, velocity, turbulence, and beam alignment. The conditions wherein continuous-wave Doppler signal intensity increased with regurgitant volume were specific but poorly predictable combinations of orifice size, flow volume, and perfect beam alignment. Under other conditions flow velocity and turbulence effects dominated, and continuous-wave Doppler signal intensity did not reflect changing regurgitant volume. Continuous-wave Doppler signal intensity-based impressions of regurgitant severity may be unreliable and even misleading under some circumstances.

  • 24.
    Bolger, Ann F
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Eidenvall, Lars
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    THE MULTIPLE DETERMINANTS OF CONTINUOUS WAVE SIGNAL INTENSITY1992Ingår i: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 86, nr 4, SArtikel i tidskrift (Refereegranskat)
  • 25.
    Boqvist, Emil
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Investigation of a swing check valve using CFD2014Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    This master’s thesis is made to increase the understanding of the dynamic characteristics of a typical large swing check valve used in a system that transports pressurized water to a reactor tank.3D FSI-simulations are performed for a number of transients in order to study the dynamic characteristics their dependence of the deceleration rate. The purpose is to find information about the dynamics that could be used in a future improvement of a 1D-model.Steady state simulations are performed for angles in the whole spectrum. Seven transient FSI-simulations with different constantly decelerating flows from 630 kg/s2 (6.7 m/s2) to 40 320 kg/s2 (430 m/s2) have been performed. The pressure on the disc caused by the hydraulic torque is integrated and the corresponding torque contribution, together with the weight torque, is used in the second law of motion to calculate the movement of the disc throughout the transients.Steady state simulations yield the pressure drop over the valve, which could be compared with field measurements in order to validate the CFD-simulations. Comparison of the pressure distribution on the disc for the steady state and transient simulations shows the importance of taking the disc angular velocity into account when modelling in 1D. Correlations between the angle, angular velocity, torque and mass flow are obtained from the transient FSI-simulations. Torque coefficients according to (Li & Liou, Vol. 125) are also brought out from the simulated transients, but in order to create a model in line with this approach further simulations have to be performed. A prediction of the pressure rise that occurs when a swing check valve closes in backward flow according to the Joukowsky equation is brought out and gives an idea of the loadings that the system has to be able to handle.

  • 26.
    Borger, Hendrik
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Model development for large scale intake manifold optimization using CFD2017Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Continued improvement of combustion engines to operate with lower fuel usage and lower harmful emissions leads to more and more complex engine designs. Computational fluid dynamics (CFD) is a method which helps predicting engine performance, reducing the reliance on engine tests. CFD can be used to optimise a geometry using a design of experiments (DOE). This study focuses on developing a simulation method to use for such large scale optimisation of air intake manifolds.

    The main focus in this study was the difference in flow quantities such as swirl number and pressure drop between the different cylinders for a given manifold. Four different simulation approaches were tested: one steady-state, two transient and one transient with a moving mesh. These simulation methods were tested on five different geometries based on a six cylinder, 13L spark ignited (Otto) combustion engine and a six cylinder, 13L compression ignited (Diesel) combustion engine. The five geometries were compared using the different simulation methods, with the main goal of determining if the different simulation methods provide the same optimal geometry. The most complex simulation model, the transient simulation with moving mesh, was chosen as main reference case in absence of experimental results.

    Results of this mock design of experiments show that the different simulation approaches do not perform consistently enough to recommend using any of the tested methods in further optimisation studies. While the various methods showed significantly different results when comparing the differences in flow parameters between cylinders, using the steady-state or transient methods to predict the flow parameters in a single cylinder is a viable approach.

    Multiple possible causes for the inconsistent results are discussed, chief among which is the chosen grid generation approach and selected convergence criteria. A recommendation is made to improve the reference, moving mesh, case using scale resolving models.

  • 27.
    Borgström, Fredrik
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Coyet, Jonas
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Waste heat recovery system with new thermoelectric materials2015Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Increasing fuel prices, higher demands on "greener" transports and tougher international emission regulations puts requirements on companies in the automotive industry in improving their vehicle fuel efficiency. On a typical heavy duty Scania truck around 30% of the total fuel energy is wasted through the exhaust system in terms of heat dissipated to the environment. Hence, several investigations and experiments are conducted trying to find ways to utilize this wasted heat in what is called a waste heat recovery (WHR) system. At Scania several techniques within the field of WHR are explored to find the profits that could be made.

    This report will cover a WHR-system based on thermoelectricity, where several new thermoelectric (TE) materials will be investigated to explore their performance. A reference material which is built into modules will be mounted in the exhaust gas stream on a truck to allow for measurements in a dyno cell. To analyze new materials a Simulink model of the WHR-system is established and validated using the dyno cell measurements. By adjusting the model to other thermoelectric material properties and data, the performance of new TE materials can be investigated and compared with today’s reference material.

    From the results of the simulations it was found that most of the investigated TE materials do not show any increased performance compared to the reference material in operating points of daily truck driving. This is due to dominance of relatively low exhaust gas temperatures in average, while most advantages in new high performing TE-materials are seen in higher temperature regions. Still, there are candidates that will be of high interest in the future if nanotechnology manufacturing process is enhanced. By using nanostructures, a quantum well based BiTe material would be capable of recovering 5-6 times more net heat power compared to the reference BiTe material. Another material group that could be of interest are TAGS which in terms of daily driving will increase the power output with pending values between 40-80 %. It is clear that for a diesel truck application, materials with high ZT-values in the lower temperature region (100-350°C) must be developed, and with focus put on exhibiting low thermal conductivity for a wide temperature span.

  • 28.
    Bradley, Andreas
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    CFD Simulations for Film Cooling: Reduced Models at Engine Like Conditions2013Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    In gas turbines some parts are exposed to combustion gases with temperatures well above the melting temperature of the material. Therefore, various cooling techniques are utilized in order to protect the parts exposed to these hot gases. One such technique, film cooling, is a common and well established way to protect the exposed parts. Film cooling involves the ejection of cold air on the surface of the parts that are to be protected, thus creating a film of colder air between the surface and the hot gases.

    Computational Fluid Dynamics (CFD) is a way of calculating fluid flow, and can be used to calculate the effectiveness of a cooling film in film cooling applications. CFD is demanding in terms of computer power, especially when advanced methods are to be used. Even the simpler methods, such as Reynolds Average Navier-Stokes (RANS), can be quite demanding, time and computer power-wise, and require resources not always available. Finding ways of limiting the needed computer power is therefore of large interest.

    The aim of this thesis is to reduce the computational time of film cooling CFD-simulations, by using reduced models. To achieve this, simulations has been conducted and compared to experiments. The investigated setup is of an enginelike equipment, where a guide vane is investigated for heat transfer coefficient and film effectiveness. The geometry in the experimental setup is constructed in such a way as to give the same pressure distribution around the guide vane as can be seen in a real gas turbine, although at lower temperatures than those in the real turbine. The CFD-simulations conducted on the test rig includes RANS-simulations using the realizable k- and the SST k-! turbulence models.

    The reduced model contains only the central part of the vane. The walls of the test rig is replaced with periodic boundary conditions. This narrow model gives good agreement with the full model for heat transfer coefficient. Due to the large computational cost required to conduct simulations with cooling on the full model no comparison were made between the cooled narrow and cooled full model.

    To further reduce the size of the computational domain, two additional models were investigated. The first one involves a reduction of the full domain to only include the section being studied, in this case the suction side of the guide vane.

    This infers a reduction of the mesh size to less than ten percent of the size of what a mesh of the cooled full domain would be. The next step to reduce the size of the model and mesh is to make a narrow version of the already shortened model. The results for these two models show that they perform adequately to each other and (in the cases where a comparison is possible), to the full domain.

    Delarbeten
    1. Fan Shaped And Cylindrical Holes Studied in a Vane Film Cooling Test Rig
    Öppna denna publikation i ny flik eller fönster >>Fan Shaped And Cylindrical Holes Studied in a Vane Film Cooling Test Rig
    Visa övriga...
    2010 (Engelska)Ingår i: Proceedings of the Asme Turbo Expo 2010, Vol 4, Pts a and B, 2010, s. 1777-1784Konferensbidrag, Publicerat paper (Refereegranskat)
    Abstract [en]

    In order to optimize the vane film cooling and thereby increase the efficiency of a gas turbine, different film cooling configurations were experimentally investigated. Dynamic similarity was obtained regarding main flow Reynolds number, airfoil pressure coefficient, adiabatic wall temperature and film cooling ejection ratio. The maximum reached Mach number was 0.52. The geometry of the test section, consisting of one vane and two flow paths, was modified in order to meet the dimensionless pressure coefficient distribution around the airfoil experienced by a full stage airfoil. This would ascertain that scaled but engine realistic pressure gradients would be achieved in the rig test.

    During the test, the cold airfoil was suddenly imposed to a hot main stream and the evaluation of both the film cooling effectiveness and the heat transfer coefficient distribution on the visiable surface could be done at one single test using timeresolved temperature measurements obtained through IR thermography. A high resolution MWIR camera was used together with a silicon viewing window. The post-processing allowed for corrections regarding emissions and determination of the desired parameters on the vane surface.

    Results, heat transfer coefficients and film cooling effectiveness, for fan shaped and cylindrical film cooling holes configurations are compared. The results show clear benefit of using shaped holes over cylindrical ditto, especially on the suction side where near hole film effectiveness is enhanced by approximately 25%, but the results also show that this benefit diminishes to nothing in the suction side trailing edge region.

    The local heat transfer coefficients are generally lower for the shaped hole configurations. Contrary to the film effectiveness the shaped holes configurations show lower heat transfer coefficients also at the suction side trailing edge region, making use of the shaped hole configurations superior to cylindrical ones as the heat flux to the surface is reduced.

    Numerical predictions using a boundary layer code, TEXSTAN, and CFD, for a smooth wall configuration corresponds well with the measured results.

    Nationell ämneskategori
    Teknik och teknologier
    Identifikatorer
    urn:nbn:se:liu:diva-91707 (URN)10.1115/GT2010-23308 (DOI)000290693500155 ()978-0-7918-4399-4 (ISBN)978-0-7918-3872-3 (ISBN)
    Konferens
    ASME Turbo Expo 2010: Power for Land, Sea, and Air, GT 2010; Glasgow; United Kingdom
    Tillgänglig från: 2013-04-30 Skapad: 2013-04-30 Senast uppdaterad: 2016-03-14Bibliografiskt granskad
    2. Towards Efficient CFD-Simulations of Engine LikeTurbine Guide Vane Film Cooling
    Öppna denna publikation i ny flik eller fönster >>Towards Efficient CFD-Simulations of Engine LikeTurbine Guide Vane Film Cooling
    Visa övriga...
    2011 (Engelska)Konferensbidrag, Publicerat paper (Övrigt vetenskapligt)
    Abstract [en]

    It is well known that the efficiency of a gas turbine can be increased by using higher combustion temperatures and that this demands improved cooling. This study focuses on strategies to decrease the turnaround time for numerical predictions of film cooling while keeping the ability to resolve details of the flow. Simulations have been carried out for a real vane geometry at close to engine-like conditions and results are compared with corresponding experiments. The investigation includes an un-cooled situation for aerodynamic validation and to determine baseline heat transfer coefficent. Simulations and experiments of film effectiveness and heat transfer coefficient and their dependence of blowing ratio are investigated.

    Ort, förlag, år, upplaga, sidor
    ARC Aerospace Research Central, 2011
    Nyckelord
    Film cooling, gas turbines, CFD
    Nationell ämneskategori
    Strömningsmekanik och akustik
    Identifikatorer
    urn:nbn:se:liu:diva-75567 (URN)10.2514/6.2011-708 (DOI)978-1-60086-950-1 (ISBN)
    Konferens
    49th AIAA Aerospace Science Meeting including the New Horizons Forum and Aerospace Exposition, January 4-7, Orlando, Florida, USA
    Tillgänglig från: 2012-03-08 Skapad: 2012-03-08 Senast uppdaterad: 2016-03-14Bibliografiskt granskad
    3. CFD Simulations Using Reduced Models for Film Cooling Design
    Öppna denna publikation i ny flik eller fönster >>CFD Simulations Using Reduced Models for Film Cooling Design
    Visa övriga...
    2011 (Engelska)Ingår i: 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition 2011, American Institute of Aeronautics and Astronautics, 2011, s. AiAA 2011-710-Konferensbidrag, Publicerat paper (Övrigt vetenskapligt)
    Abstract [en]

    Film cooling technologies are widely used for attaining high efficiency in gas turbine engines. In this study we have investigated the potential for reduced models to capture different aspects of film cooling by means of CFD at low turn-around time while maintaining the accuracy at a reasonable level. CFD simulations and experiments were carried out for an engine-like setting. Subsequently, the computational domain was reduced in two steps in order to decrease the simulation time. Results for all models are compared with experimental data, including aerodynamic validation, heat transfer coefficient and film effectiveness. The aerodynamic results are very similar for experiments and simulations, and the heat transfer coefficient and film cooling effectiveness showed similarities within the expected range. Thus, this strategy could be very useful for e.g. early vane and film cooling design.

    Ort, förlag, år, upplaga, sidor
    American Institute of Aeronautics and Astronautics, 2011
    Nyckelord
    Film Cooling, Gas Turbines, CFD
    Nationell ämneskategori
    Maskinteknik
    Identifikatorer
    urn:nbn:se:liu:diva-76905 (URN)10.2514/6.2011-710 (DOI)978-1-60086-950-1 (ISBN)
    Konferens
    49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition, 4–7 January 2011, Orlando, Florida
    Tillgänglig från: 2012-04-24 Skapad: 2012-04-24 Senast uppdaterad: 2016-05-11Bibliografiskt granskad
  • 29.
    Bradley, Andreas
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Prediction of vane lm cooling in gas turbines Correlations and Parameters2009Rapport (Övrigt vetenskapligt)
    Abstract [en]

    When designing gas turbines, a high combustion temperature is desirable to obtain a good thermal eciency. At the same time, the thermal limitations of the gas turbines components must not be exceeded. High temperatures can lead to large thermal stresses that can reduce the life span of the components and increase the risk of fatigue and failure.

    The trade-o between eciency on the one hand, and reliability, life span, service interval etc. on the other hand, must be handled early in the design process. At the same time, many other aspects such as aerodynamics, structural strength, manufacturing and assembly must be considered simultaneously.

    In the combustor and high pressure turbine, lm cooling is extensively used as one of the major ways to protect parts from the gases of combustion. Film cooling was introduced about 50 years ago, and is today normally actualized by taking air from the compressor and ejecting it out through rows of holes placed on the surfaces that are to be protected.

    Film cooling is a complex process, in uenced by many parameters related to the hole geometry, the flow through the hole, and the free stream above the surface of interest, see e.g. A number of governing parameters have been identied, and their effect has been analyzed, see e.g.

    In order to handle the design of lm cooling along with the rest of the design process, fast and relatively accurate tools for prediction and comparison of film cooling congurations are essential. One early attempt to describe film cooling by a correlation was carried out in the sixties. Since then a number of correlations have been developed and scrutinized, but most of them have considered  at plates without pressure gradients, a case that is not always representative for gas turbine lm cooling. Furthermore, most correlations are developed utilizing experiments, where at least some of the parameters in the correlation have been adopted to t particular experimental data. This give rise to questions regarding, among others, the possibility to generalize the result of the correlations to other presumptions. This investigation summarize some of the correlations presented in the open literature, and discuss their strengths and weaknesses.

  • 30.
    Bradley, Andreas
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Gårdhagen, Roland
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Bird-Like Wing Conguration for Pitch Control of a Tailless Aircraft2012Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    A numerical study of a small bird-like aircraft has been performed. The aim of the study was to investigate how a swing wing (actualized through a constant span morphing wing) can be used for pitch control of a tailless aircraft. The results show that a swing wing can be successfully used, and that the aircraft can be maintained in a trimmed state by only small adjustments of part of the wing. A comparison was also made with a Vortex lattice method, but these results significantly deviated from those obtained with CFD. Copyright © 2012 by the American Institute of Aeronautics and Astronautics, Inc.

  • 31.
    Bradley, Andreas
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Nadali Najafabadi, Hossein
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wren, Joakim
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Utriainen, Esa
    Kinell, Mats
    Towards Efficient CFD-Simulations of Engine LikeTurbine Guide Vane Film Cooling2011Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    It is well known that the efficiency of a gas turbine can be increased by using higher combustion temperatures and that this demands improved cooling. This study focuses on strategies to decrease the turnaround time for numerical predictions of film cooling while keeping the ability to resolve details of the flow. Simulations have been carried out for a real vane geometry at close to engine-like conditions and results are compared with corresponding experiments. The investigation includes an un-cooled situation for aerodynamic validation and to determine baseline heat transfer coefficent. Simulations and experiments of film effectiveness and heat transfer coefficient and their dependence of blowing ratio are investigated.

  • 32.
    Bradley, Andreas
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wren, Joakim
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Comparison of Correlations and Experiments for Prediction of Vane Film Cooling in Gas Turbines2010Rapport (Övrigt vetenskapligt)
    Abstract [en]

    In an earlier report by Bradley, a number of correlations from the open literature were presented and evaluated. All these correlations manage to accurately describe the film cooling eectiveness for the experiments they are based on, but there is doubts regarding the general predictive value of these correlations, especially for engine-like conditions. The correlations have now been analysed to investigate their predictive capabilities - especially the general applicability of correlations is in focus, for example for geometries or flow conditions slightly dierent than those for which the correlations were originally designed.

  • 33.
    Casas Garcia, Belén
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Lantz, Jonas
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Viola, Frederica
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten.
    Cedersund, Gunnar
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Bolger, Ann F.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. University of Calif San Francisco, CA USA.
    Carlhäll, Carljohan
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Bridging the gap between measurements and modelling: a cardiovascular functional avatar2017Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 6214Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Lumped parameter models of the cardiovascular system have the potential to assist researchers and clinicians to better understand cardiovascular function. The value of such models increases when they are subject specific. However, most approaches to personalize lumped parameter models have thus far required invasive measurements or fall short of being subject specific due to a lack of the necessary clinical data. Here, we propose an approach to personalize parameters in a model of the heart and the systemic circulation using exclusively non-invasive measurements. The personalized model is created using flow data from four-dimensional magnetic resonance imaging and cuff pressure measurements in the brachial artery. We term this personalized model the cardiovascular avatar. In our proof-of-concept study, we evaluated the capability of the avatar to reproduce pressures and flows in a group of eight healthy subjects. Both quantitatively and qualitatively, the model-based results agreed well with the pressure and flow measurements obtained in vivo for each subject. This non-invasive and personalized approach can synthesize medical data into clinically relevant indicators of cardiovascular function, and estimate hemodynamic variables that cannot be assessed directly from clinical measurements.

  • 34.
    Colombi, Raffaele
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    CFD Investigation of Aerodynamic Drag Reduction for an Unloaded Timber Truck2018Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The road transport industry is facing a strong need for fuel consumption reduction, driven by the necessity of decreasing polluting emissions, such as CO2 and NOX, as well as coping with strict regulations and increasing fuel costs. For road vehicles the aerodynamic drag constitutes a major source of energy consumption, and for this reason improving the aerodynamic performance of the vehicle is an established approach for reducing fuel consumption and greenhouse gases emissions.

    In this Thesis work, Computational Fluid Dynamics (CFD) investigations have been carried out in order to investigate and improve the aerodynamic performance of an unloaded timber truck. The work has been divided in two parts. In a first phase, a preliminary study was carried out on a simplified tractor-trailer model in order to establish a suitable computational grid and turbulence model. The hexcore-mesh showed a better performance over the tet- and poly-mesh types. Among the selected RANS turbulence models, the Realizable kε with Enhanced Wall Treatment (EWT) and y+ > 30 showed the highest reliability of results in

    comparison with experimental data and existing CFD investigations.

    In a second phase, the flow field around the baseline unloaded timber truck was analysed in order to highlight potential regions for drag reduction. The truck cabin-bulkhead gap, bunks, the exposed wheels and the stakes were found make key contribution to the drag build-up. The analysis confirmed the 5-yaw case to be the most representative for the wind-averaged drag coefficient.

    Geometry modifications were implemented in order to improve the aerodynamic performance in the selected areas, and subsequently combined into aero-kits in order to enhance the performance, analysed for the 5-yaw case. The combination of extended side skirts, bulkhead shield and collapsed stakes yielded a remarkable result of more than 30% decrease in the wind-averaged drag coefficient, achieved by reducing the flow separation on the cabin leeward A-pillar, and by shielding areas of high stagnation pressure from the side wind.

    Furthermore, a parallel study was conducted on the development of a procedure for the automatic post-processing of results. The outcome was a set of Python scripts to be used with Kitaware Paraview in order to automatically obtain figures of surface variables distributions, iso-surfaces, velocity profiles, drag build-up and total pressure contours. The procedure was finally extended to include the case comparison.

  • 35.
    de Vries, Frank
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Inverkan av värme på lagerlägets cylindricitet i ett lagerhus2010Självständigt arbete på grundnivå (högskoleexamen), 10,5 poäng / 16 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Det här examensarbetet har utförts hos och med stöd av SKF Mekan i Katrineholm. Grundfrågeställningen som innebar upphovet till examensarbetet är om värme påverkar lagerlägets cylindricitet hos ett lagerhus. Detta avgränsas senare till att gälla enbart värmepåverkan under produktion för en typ av lagerhus i en storlek men tre olika materialval. Därmed koncentreras arbetet på gjuterilinan för de mindre lagerhusen samt den bearbetningslina som kallas ”Robot line”.

    Inledningsvis ges en presentation vad lager och lagerhus är samt vilken funktion de fyller. Därefter ges en överblick av gjuteriet samt bearbetningen. Berörda linor betraktas mer ingående men även övriga linor ges en övergripande bild av. Övriga resurser såsom mätrum samt testlabb presenteras också.

    De tre olika materialen granskas för att se vilka avgörande skillnader som finns dem emellan. Detta med hjälp av litteratur samt intervjuer med medarbetare hos SKF Mekan, personal vid Linköpings universitet samt SWEREA.

    Två test som genomförts under arbetets gång beskrivs, varav det ena lyckat men det andra misslyckat. Dock fick det andra testet ett överraskande resultat.

    Befintliga kontroller längs med produktionskedjan omtalas.

    Slutligen sammanfattas vilka moment inom gjuteri- samt bearbetningsprocessen där toleransen för cylindriciteten hos lagerläget riskerar att under-/överskridas samt vad som då är orsaken.

  • 36.
    Diczfalusy, Elin
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Dizdar (Dizdar Segrell), Nil
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Neurologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i centrala Östergötland, Neurologiska kliniken.
    Zsigmond, Peter
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Neurokirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Sinnescentrum, Neurokirurgiska kliniken US.
    Kullman, Anita
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk kemi. Linköpings universitet, Hälsouniversitetet.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wårdell, Karin
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Simulations and visualizations for interpretation of brain microdialysis data during deep brain stimulation2012Ingår i: IEEE Engineering in Medicine and Biology Society (EMBC), 2012, IEEE , 2012, s. 6438-6441Konferensbidrag (Refereegranskat)
    Abstract [en]

    Microdialysis of the basal ganglia was used in parallel to deep brain stimulation (DBS) for patients with Parkinson’s disease. The aim of this study was to patientspecifically simulate and visualize the maximum tissue volume of influence (TVImax) for each microdialysis catheter and the electric field generated around each DBS electrode. The finite element method (FEM) was used for the simulations. The method allowed mapping of the anatomical origin of the microdialysis data and the electric stimulation for each patient. It  was seen that the sampling and stimulation targets differed among the patients, and the results will therefore be used in the future interpretation of the biochemical data.

  • 37.
    Diczfalusy, Elin
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    Zsigmond, Peter
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Neurokirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Sinnescentrum, Neurokirurgiska kliniken US.
    Dizdar (Dizdar Segrell), Nil
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Neurologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i centrala Östergötland, Neurologiska kliniken.
    Kullman, Anita
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk kemi. Linköpings universitet, Hälsouniversitetet.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wårdell, Karin
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
    A model for simulation and patient-specific visualization of the tissue volume of influence during brain microdialysis2011Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 49, nr 12, s. 1459-1469Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Microdialysis can be used in parallel to deep brain stimulation (DBS) to relate biochemical changes to the clinical outcome. The aim of the study was to use the finite element method to predict the tissue volume of influence (TVI(max)) and its cross-sectional radius (r (TVImax)) when using brain microdialysis, and visualize the TVI(max) in relation to patient anatomy. An equation based on Fick's law was used to simulate the TVI(max). Factorial design and regression analysis were used to investigate the impact of the diffusion coefficient, tortuosity and loss rate on the r (TVImax). A calf brain tissue experiment was performed to further evaluate these parameters. The model was implemented with pre-(MRI) and post-(CT) operative patient images for simulation of the TVI(max) for four patients undergoing microdialysis in parallel to DBS. Using physiologically relevant parameter values, the r (TVImax) for analytes with a diffusion coefficient D = 7.5 × 10(-6) cm(2)/s was estimated to 0.85 ± 0.25 mm. The simulations showed agreement with experimental data. Due to an implanted gold thread, the catheter positions were visible in the post-operative images. The TVI(max) was visualized for each catheter. The biochemical changes could thereby be related to their anatomical origin, facilitating interpretation of results.

  • 38.
    Djerf, K
    et al.
    Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Linköping.
    Edholm, P
    Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Linköping.
    Hedbrant, Johan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    A simplified roentgen stereophotogrammetric method. Analysis of small movements between the prosthetic stem and the femur after total hip replacement.1987Ingår i: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 28, nr 5, s. 603-606Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A simplified roentgen stereophotogrammetric method is described. It is based on the use of a 50 mm thick reference plate consisting of a carbon-fibre-reinforced polyester box. The patient is placed directly on this box, which makes the methods less cumbersome and more suitable for routine use. The method has been tested in a model experiment designed for detecting small movements between femur and prosthesis at an early stage after total hip replacement. The head and two hemispheres on the prosthesis and three small tantalum balls inserted in the femur serve as reference points. The model experiment now reported shows that the method has acceptable precision.

  • 39.
    Dyverfeldt, Petter
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Extending MRI to the Quantification of Turbulence Intensity2010Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    In cardiovascular medicine, the assessment of blood flow is fundamental to the understanding and detection of disease. Many pharmaceutical, interventional, and surgical treatments impact the flow. The primary purpose of the cardiovascular system is to drive, control and maintain blood flow to all parts of the body. In the normal cardiovascular system, fluid transport is maintained at high efficiency and the blood flow is essentially laminar. Disturbed and turbulent blood flow, on the other hand, appears to be present in many cardiovascular diseases and may contribute to their initiation and progression. Despite strong indications of an important interrelationship between flow and cardiovascular disease, medical imaging has lacked a non-invasive tool for the in vivo assessment of disturbed and turbulent flow. As a result, the extent and role of turbulence in the blood flow of humans have not yet been fully investigated.

    Magnetic resonance imaging (MRI) is a versatile tool for the non-invasive assessment of flow and has several important clinical and research applications, but might not yet have reached its full potential. Conventional MRI techniques for the assessment of flow are based on measurements of the mean velocity within an image voxel. The mean velocity corresponds to the first raw moment of the distribution of velocities within a voxel. An MRI framework for the quantification of any moment (mean, standard deviation, skew, etc.) of arbitrary velocity distributions is presented in this thesis.

    Disturbed and turbulent flows are characterized by velocity fluctuations that are superimposed on the mean velocity. The intensity of these velocity fluctuations can be quantified by their standard deviation, which is a commonly used measure of turbulence intensity. This thesis focuses on the development of a novel MRI method for the quantification of turbulence intensity. This method is mathematically derived and experimentally validated. Limitations and sources of error are investigated and guidelines for adequate application of MRI measurements of turbulence intensity are outlined. Furthermore, the method is adapted to the quantification of turbulence intensity in the pulsatile blood flow of humans and applied to a wide range of cardiovascular diseases. In these applications, elevated turbulence intensity was consistently detected in regions where highly disturbed flow was anticipated, and the effects of potential sources of errors were small.

    Diseased heart valves are often replaced with prosthetic heart valves, which, in spite of improved benefits and durability, continue to fall short of matching native flow patterns. In an in vitro setting, MRI was used to visualize and quantify turbulence intensity in the flow downstream from four common designs of prosthetic heart valves. Marked differences in the extent and degree of turbulence intensity were detected between the different valves.

    Mitral valve regurgitation is a common valve lesion associated with progressive left atrial and left ventricular remodelling, which may often require surgical correction to avoid irreversible ventricular dysfunction. The spatiotemporal dynamics of flow disturbances in mitral regurgitation were assessed based on measurements of flow patterns and turbulence intensity in a group of patients with significant regurgitation arising from similar valve lesions. Peak turbulence intensity occurred at the same time in all patients and the total turbulence intensity in the left atrium appeared closely related to the severity of regurgitation.

    MRI quantification of turbulence intensity has the potential to become a valuable tool in investigating the extent, timing and role of disturbed blood flow in the human cardiovascular system, as well as in the assessment of the effects of different therapeutic options in patients with vascular or valvular disorders.

    Delarbeten
    1. Quantification of intravoxel velocity standard deviation and turbulence intensity by generalizing phase-contrast MRI
    Öppna denna publikation i ny flik eller fönster >>Quantification of intravoxel velocity standard deviation and turbulence intensity by generalizing phase-contrast MRI
    2006 (Engelska)Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 56, nr 4, s. 850-858Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Turbulent flow, characterized by velocity fluctuations, is a contributing factor to the pathogenesis of several cardiovascular diseases. A clinical noninvasive tool for assessing turbulence is lacking, however. It is well known that the occurrence of multiple spin velocities within a voxel during the influence of a magnetic gradient moment causes signal loss in phase-contrast magnetic resonance imaging (PC-MRI). In this paper a mathematical derivation of an expression for computing the standard deviation (SD) of the blood flow velocity distribution within a voxel is presented. The SD is obtained from the magnitude of PC-MRI signals acquired with different first gradient moments. By exploiting the relation between the SD and turbulence intensity (TI), this method allows for quantitative studies of turbulence. For validation, the TI in an in vitro flow phantom was quantified, and the results compared favorably with previously published laser Doppler anemometry (LDA) results. This method has the potential to become an important tool for the noninvasive assessment of turbulence in the arterial tree.

    Nyckelord
    phase-contrast magnetic resonance imaging, turbulent flow, intravoxel velocity distribution, turbulence intensity, atherosclerosis
    Nationell ämneskategori
    Medicin och hälsovetenskap Fysiologi Strömningsmekanik och akustik Medicinsk laboratorie- och mätteknik
    Identifikatorer
    urn:nbn:se:liu:diva-37249 (URN)10.1002/mrm.21022 (DOI)000240897000017 ()34073 (Lokalt ID)34073 (Arkivnummer)34073 (OAI)
    Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2018-01-13
    2. On MRI turbulence quantification
    Öppna denna publikation i ny flik eller fönster >>On MRI turbulence quantification
    Visa övriga...
    2009 (Engelska)Ingår i: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 27, nr 7, s. 913-922Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Turbulent flow, characterized by velocity fluctuations, accompanies many forms of cardiovascular disease and may contribute to their progression and hemodynamic consequences. Several studies have investigated the effects of turbulence on the magnetic resonance imaging (MRI) signal. Quantitative MRI turbulence measurements have recently been shown to have great potential for application both in human cardiovascular flow and in engineering flow. In this article, potential pitfalls and sources of error in MRI turbulence measurements are theoretically and numerically investigated. Data acquisition strategies suitable for turbulence quantification are outlined. The results show that the sensitivity of MRI turbulence measurements to intravoxel mean velocity variations is negligible, but that noise may degrade the estimates if the turbulence encoding parameter is set improperly. Different approaches for utilizing a given amount of scan time were shown to influence the dynamic range and the uncertainty in the turbulence estimates due to noise. The findings reported in this work may be valuable for both in vitro and in vivo studies employing MRI methods for turbulence quantification.

    Nyckelord
    Turbulence quantification, Turbulent flow, Phase-contrast magnetic resonance imaging, Constriction, Numerical flow phantom
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-20746 (URN)10.1016/j.mri.2009.05.004 (DOI)000269613000004 ()
    Anmärkning

    Original Publication: Petter Dyverfeldt, Roland Gårdhagen, Andreas Sigfridsson, Matts Karlsson and Tino Ebbers, On MRI turbulence quantification, 2009, MAGNETIC RESONANCE IMAGING, (27), 7, 913-922. http://dx.doi.org/10.1016/j.mri.2009.05.004 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/

    Tillgänglig från: 2009-09-18 Skapad: 2009-09-18 Senast uppdaterad: 2017-12-13
    3. Assessment of fluctuating velocities in disturbed cardiovascular blood flow: in vivo feasibility of generalized phase-contrast MRI
    Öppna denna publikation i ny flik eller fönster >>Assessment of fluctuating velocities in disturbed cardiovascular blood flow: in vivo feasibility of generalized phase-contrast MRI
    Visa övriga...
    2008 (Engelska)Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 28, nr 3, s. 655-663Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Purpose

    To evaluate the feasibility of generalized phase-contrast magnetic resonance imaging (PC-MRI) for the noninvasive assessment of fluctuating velocities in cardiovascular blood flow.

    Materials and Methods

    Multidimensional PC-MRI was used in a generalized manner to map mean flow velocities and intravoxel velocity standard deviation (IVSD) values in one healthy aorta and in three patients with different cardiovascular diseases. The acquired data were used to assess the kinetic energy of both the mean (MKE) and the fluctuating (TKE) velocity field.

    Results

    In all of the subjects, both mean and fluctuating flow data were successfully acquired. The highest TKE values in the patients were found at sites characterized by abnormal flow conditions. No regional increase in TKE was found in the normal aorta.

    Conclusion

    PC-MRI IVSD mapping is able to detect flow abnormalities in a variety of human cardiovascular conditions and shows promise for the quantitative assessment of turbulence. This approach may assist in clarifying the role of disturbed hemodynamics in cardiovascular diseases.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-43135 (URN)10.1002/jmri.21475 (DOI)000259106900013 ()71980 (Lokalt ID)71980 (Arkivnummer)71980 (OAI)
    Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13
    4. In Vitro Assessment of Flow Patterns and Turbulence Intensity in Prosthetic Heart Valves Using Generalized Phase-Contrast Magnetic Resonance Imaging
    Öppna denna publikation i ny flik eller fönster >>In Vitro Assessment of Flow Patterns and Turbulence Intensity in Prosthetic Heart Valves Using Generalized Phase-Contrast Magnetic Resonance Imaging
    Visa övriga...
    (Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Purpose: To assess in vitro the three-dimensional mean velocity field and the extent and degree of turbulenceintensity in different prosthetic heart valves using a generalization of phase-contrast magnetic resonance imaging(PC-MRI).

    Material and Methods: Four 27 mm aortic valves (Björk-Shiley Monostrut tilting-disc, St. Jude MedicalStandard bileaflet, Medtronic Mosaic stented and Freestyle stentless porcine valve) were tested under steadyinflow conditions in a Plexiglas phantom. Three-dimensional PC-MRI data were acquired to measure the meanvelocity field and the turbulent kinetic energy (TKE), a direction-independent measure of turbulence intensity.

    Results: Velocity and turbulence intensity estimates could be obtained up and downstream of the valves, exceptwhere metallic structure in the valves caused signal void. Distinct differences in the location, extent and peakvalues of velocity and turbulence intensity were observed between the valves tested. The maximum values ofTKE varied between the different valves: tilting disc, 100 J/m3; bileaflet, 115 J/m3; stented, 200 J/m3; stentless,145 J/m3.

    Conclusion: The turbulence intensity downstream from a prosthetic heart valve is dependent on the specificvalve design. Generalized PC-MRI can be used to quantify velocity and turbulence intensity downstream fromprosthetic heart valves, which may allow assessment of these aspects of prosthetic valvular function inpostoperative patients.

    Nyckelord
    Turbulence intensity, prosthetic heart valves, phase-contrast magnetic resonance imaging
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-53189 (URN)
    Tillgänglig från: 2010-01-19 Skapad: 2010-01-19 Senast uppdaterad: 2013-09-03Bibliografiskt granskad
    5. Hemodynamic aspects of mitral regurgitation assessed by generalized phase-contrast MRI
    Öppna denna publikation i ny flik eller fönster >>Hemodynamic aspects of mitral regurgitation assessed by generalized phase-contrast MRI
    Visa övriga...
    2011 (Engelska)Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 33, nr 3, s. 582-588Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Purpose: Mitral regurgitation creates a high velocity jet into the left atrium (LA), contributing both volume andpressure; we hypothesized that the severity of regurgitation would be reflected in the degree of LA flowdistortion.

    Material and Methods: Three-dimensional cine PC-MRI was applied to determine LA flow patterns andturbulent kinetic energy (TKE) in seven subjects (five patients with posterior mitral leaflet prolapse, two normalsubjects). In addition, the regurgitant volume and the time-velocity profiles in the pulmonary veins weremeasured.

    Results: The LA flow in the mitral regurgitation patients was highly disturbed with elevated values of TKE.Peak TKE occurred consistently at late systole. The total LA TKE was closely related to the regurgitant volume.LA flow patterns were characterized by a pronounced vortex in proximity to the regurgitant jet. In some patients,pronounced discordances were observed between individual pulmonary venous inflows, but these could not berelated to the direction of the flow jet or parameters describing global LA hemodynamics.

    Conclusion: PC-MRI permits investigations of atrial and pulmonary vein flow patterns and TKE in significantmitral regurgitation, reflecting the impact of the highly disturbed blood flow that accompanies this importantvalve disease.

    Ort, förlag, år, upplaga, sidor
    John Wiley and Sons, 2011
    Nyckelord
    Hemodynamics, mitral valve insufficiency, turbulent flow, phase-contrast magnetic resonance imaging, pulmonary veins, blood flow velocity
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-53190 (URN)10.1002/jmri.22407 (DOI)000287951100009 ()
    Tillgänglig från: 2010-01-19 Skapad: 2010-01-19 Senast uppdaterad: 2017-12-12
  • 40.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi.
    Escobar Kvitting, John-Peder
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Carlhäll, Carl Johan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Boano, Gabriella
    Östergötlands Läns Landsting, Hjärtcentrum, Kardiologiska kliniken.
    Sigfridsson, Andreas
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Hermansson, Ulf
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Bolger, Ann F.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi.
    Hemodynamic aspects of mitral regurgitation assessed by generalized phase-contrast MRI2011Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 33, nr 3, s. 582-588Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Mitral regurgitation creates a high velocity jet into the left atrium (LA), contributing both volume andpressure; we hypothesized that the severity of regurgitation would be reflected in the degree of LA flowdistortion.

    Material and Methods: Three-dimensional cine PC-MRI was applied to determine LA flow patterns andturbulent kinetic energy (TKE) in seven subjects (five patients with posterior mitral leaflet prolapse, two normalsubjects). In addition, the regurgitant volume and the time-velocity profiles in the pulmonary veins weremeasured.

    Results: The LA flow in the mitral regurgitation patients was highly disturbed with elevated values of TKE.Peak TKE occurred consistently at late systole. The total LA TKE was closely related to the regurgitant volume.LA flow patterns were characterized by a pronounced vortex in proximity to the regurgitant jet. In some patients,pronounced discordances were observed between individual pulmonary venous inflows, but these could not berelated to the direction of the flow jet or parameters describing global LA hemodynamics.

    Conclusion: PC-MRI permits investigations of atrial and pulmonary vein flow patterns and TKE in significantmitral regurgitation, reflecting the impact of the highly disturbed blood flow that accompanies this importantvalve disease.

  • 41.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Escobar Kvitting, John-Peder
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Bolger, Ann F
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Assessment of fluctuating velocities in disturbed cardiovascular blood flow: in vivo feasibility of generalized phase-contrast MRI2008Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 28, nr 3, s. 655-663Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose

    To evaluate the feasibility of generalized phase-contrast magnetic resonance imaging (PC-MRI) for the noninvasive assessment of fluctuating velocities in cardiovascular blood flow.

    Materials and Methods

    Multidimensional PC-MRI was used in a generalized manner to map mean flow velocities and intravoxel velocity standard deviation (IVSD) values in one healthy aorta and in three patients with different cardiovascular diseases. The acquired data were used to assess the kinetic energy of both the mean (MKE) and the fluctuating (TKE) velocity field.

    Results

    In all of the subjects, both mean and fluctuating flow data were successfully acquired. The highest TKE values in the patients were found at sites characterized by abnormal flow conditions. No regional increase in TKE was found in the normal aorta.

    Conclusion

    PC-MRI IVSD mapping is able to detect flow abnormalities in a variety of human cardiovascular conditions and shows promise for the quantitative assessment of turbulence. This approach may assist in clarifying the role of disturbed hemodynamics in cardiovascular diseases.

  • 42.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    Escobar Kvitting, John-Peder
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Sigfridsson, Andreas
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Engvall, Jan
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Bolger, Ann F
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ebbers, Tino
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    In-vivo quantification of turbulent velocity fluctuations2007Ingår i: 15th Int Soc Magn Reson Med,2007, 2007Konferensbidrag (Övrigt vetenskapligt)
  • 43.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Gårdhagen, Roland
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Sigfridsson, Andreas
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tinno
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    MRI Turbulence Quantification2009Ingår i: Proc. Intl. Soc. Mag. Reson. Med., 2009, s. 1858-Konferensbidrag (Refereegranskat)
  • 44.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Gårdhagen, Roland
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    On MRI turbulence quantification2009Ingår i: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 27, nr 7, s. 913-922Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Turbulent flow, characterized by velocity fluctuations, accompanies many forms of cardiovascular disease and may contribute to their progression and hemodynamic consequences. Several studies have investigated the effects of turbulence on the magnetic resonance imaging (MRI) signal. Quantitative MRI turbulence measurements have recently been shown to have great potential for application both in human cardiovascular flow and in engineering flow. In this article, potential pitfalls and sources of error in MRI turbulence measurements are theoretically and numerically investigated. Data acquisition strategies suitable for turbulence quantification are outlined. The results show that the sensitivity of MRI turbulence measurements to intravoxel mean velocity variations is negligible, but that noise may degrade the estimates if the turbulence encoding parameter is set improperly. Different approaches for utilizing a given amount of scan time were shown to influence the dynamic range and the uncertainty in the turbulence estimates due to noise. The findings reported in this work may be valuable for both in vitro and in vivo studies employing MRI methods for turbulence quantification.

  • 45.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Sigfridsson, Andreas
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Escobar Kvitting, John-Peder
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Quantification of intravoxel velocity standard deviation and turbulence intensity by generalizing phase-contrast MRI2006Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 56, nr 4, s. 850-858Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Turbulent flow, characterized by velocity fluctuations, is a contributing factor to the pathogenesis of several cardiovascular diseases. A clinical noninvasive tool for assessing turbulence is lacking, however. It is well known that the occurrence of multiple spin velocities within a voxel during the influence of a magnetic gradient moment causes signal loss in phase-contrast magnetic resonance imaging (PC-MRI). In this paper a mathematical derivation of an expression for computing the standard deviation (SD) of the blood flow velocity distribution within a voxel is presented. The SD is obtained from the magnitude of PC-MRI signals acquired with different first gradient moments. By exploiting the relation between the SD and turbulence intensity (TI), this method allows for quantitative studies of turbulence. For validation, the TI in an in vitro flow phantom was quantified, and the results compared favorably with previously published laser Doppler anemometry (LDA) results. This method has the potential to become an important tool for the noninvasive assessment of turbulence in the arterial tree.

  • 46.
    Dyverfeldt, Petter
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Knutsson, Hans
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tino
    Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära.
    A novel MRI framework for the quantification of any moment of arbitrary velocity distributions2011Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 65, nr 3, s. 725-731Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    MRI can measure several important hemodynamic parameters but might not yet have reached its full potential. The most common MRI method for the assessment of flow is phase-contrast MRI velocity mapping that estimates the mean velocity of a voxel. This estimation is precise only when the intravoxel velocity distribution is symmetric. The mean velocity corresponds to the first raw moment of the intravoxel velocity distribution. Here, a generalized MRI framework for the quantification of any moment of arbitrary velocity distributions is described. This framework is based on the fact that moments in the function domain (velocity space) correspond to differentials in the Fourier transform domain (kv-space). For proof-of-concept, moments of realistic velocity distributions were estimated using finite difference approximations of the derivatives of the MRI signal. In addition, the framework was applied to investigate the symmetry assumption underlying phase-contrast MRI velocity mapping; we found that this assumption can substantially affect phase-contrast MRI velocity estimates and that its significance can be reduced by increasing the velocity encoding range.

  • 47.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Flow Imaging: Cardiac Applications of 3D Cine Phase-Contrast MRI2011Ingår i: Current Cardiovascular Imaging Reports, ISSN 1941-9074, Vol. 4, nr 2, s. 127-133Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Global and regional blood flow dynamics are of pivotal importance to cardiac function. Fluid mechanical forces can affect hemolysis and platelet aggregation, as well as myocardial remodeling. In recent years, assessment of blood flow patterns based on time-resolved, three-dimensional, three-directional phase-contrast MRI (3D cine PC MRI) has become possible and rapidly gained popularity. Initially, this technique was mainly known for its intuitive and appealing visualizations of the cardiovascular blood flow. Most recently, the technique has begun to go beyond compelling images toward comprehensive and quantitative assessment of blood flow. In this article, cardiac applications of 3D cine PC MRI data are discussed, starting with a review of the acquisition and analysis techniques, and including descriptions of promising applications of cardiac 3D cine PC MRI for the clinical evaluation of myocardial, valvular, and vascular disorders.

  • 48. EIDENVALL, L
    et al.
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    DETERMINATION OF REGURGITANT FLOW IN A PULSATILE MODEL BY INTEGRATING VELOCITIES FROM THE ENTIRE 3D PROXIMAL VELOCITY-FIELD1993Ingår i: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 88, nr 4, 2Artikel i tidskrift (Refereegranskat)
  • 49. Eidenvall, Lars
    et al.
    Sjöberg, Birgitta Janero
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Two-dimensional color Doppler flow velocity profiles can be time corrected with an external ECG-delay device.1992Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 5, nr 4, s. 405-413Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Although two-dimensional ultrasound color flow imaging is often considered to be a real-time technique, the acquisition time for two-dimensional color images may be up to 200 msec. Time correction is therefore necessary to obtain correct flow velocity profiles. We have developed a time-correction method in which a specially designed unit detects the QRS complex from the patient and creates a trig pulse that is delayed incrementally in relation to the QRS complex. This trig pulse controls the acquisition of the ultrasound images. A number of consecutively delayed images, with known incremental delay between the sweeps, can thus be stored in the memory of the echocardiograph and transferred digitally to a computer. The time-corrected flow velocity profile is obtained by interpolation of data from the time-delayed profiles. The system was evaluated in a Doppler string phantom test. With this technique it is possible to study time-corrected flow velocity profiles without the need to alter existing ultrasound Doppler equipment.

  • 50. Eidenvall, Lars
    et al.
    Sjöberg, Birgitta Janero
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Loyd, Dan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ask, Per
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan.
    INFORMATION IN THE AORTIC BLOOD VELOCITY SIGNAL - A SIMULATION STUDY1991Ingår i: PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 13, PTS 1-5, 1991, s. 2248-2249Konferensbidrag (Refereegranskat)
123456 1 - 50 av 290
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