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  • 1.
    Aaboen, Lise
    et al.
    Department of Industrial Economics and Technology Management, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
    Fredriksson, Anna
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Kommunikations- och transportsystem. Linköpings universitet, Tekniska fakulteten.
    The relationship development aspect of production transfer2016Inngår i: Journal of Purchasing and Supply Management, ISSN 1478-4092, E-ISSN 1873-6505, Vol. 22, nr 1, s. 53-65Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Production transfers are a result of outsourcing and offshoring decisions. Because of the strategic focus of the outsourcing literature, the operational issues of relationship development between sender and receiver and its impact on the transfer progress have not been fully depicted. The purpose of the present paper is to explore relationship development during production transfer. To fulfil this purpose, we studied three different production transfers and derived four propositions for further testing. Our main conclusions included that dependence and power gradually shift between the sender and the receiver and that the relationship between them sets the arena for what types of relationships can be developed between the receiver and the suppliers. Furthermore, short social distances can bridge cultural and technological distances to some extent, because it motivates the actors to bring their relationship into a more developed state. Finally, we noticed that the headquarters’ involvement can work both as an inhibitor as well as a converter.

    Fulltekst (pdf)
    fulltext
  • 2.
    Aarts, B.
    et al.
    Netherlands Forensic Institute, Biological Traces and DNA, The Hague, Netherlands.
    Kokshoorn, B.
    Netherlands Forensic Institute, Biological Traces and DNA, The Hague, Netherlands.
    Mc Kenna, L.G.
    Forensic Science Ireland, DNA department, Dublin, Ireland.
    Drotz, W.
    Swedish National Forensic Centre, DNA department, Linköping, Sweden.
    Ansell, Ricky
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. Swedish National Forensic Centre, DNA department, Linköping, Sweden.
    van Oorschot, R.A.
    Office of the Chief Forensic Scientist, Victoria Police Forensic Services Department, Macleod- Victoria, Australia.
    Kloosterman, A.D.
    Netherlands Forensic Institute, Biological Traces and DNA, The Hague, Netherlands.
    DNActivity: International cooperation in activity level interpretation of forensic DNA evidence.2015Inngår i: Abstract book, 7th European Academy of Forensic Science, EAFS, Prag, Tjeckien, 2015., 2015, s. 555-Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    Questions posed to expert witnesses by the legal community and the courts are expanding to include not just those relating to source level (i.e. ‘who is the donor of the trace?’) but also those relating to activitity level (i.e. ‘how did the DNA get there?’). The answers to these questions are usually formulated as the probability of the evidence under alternative scenarios. As activity level questions are part of investigative and legal considerations it is of paramount importance that expert witnesses are provided with knowledge and tools to address these questions.

    To answer such questions within a probabilistic framework, empirical data is needed to estimate probabilities of transfer, persistence and recovery of DNA as well as background levels of DNA on everyday objects. There is a paucity of empirical data on these topics, but the number of studies is increasing both through in-house experiments and experimental data published in international scientific journals.

    Laboratories that conduct such studies all use different experimental setups, trace recovery strategies and techniques and DNA analysis systems and equipment. It is essential for the forensic genetics community in general to establish whether the data generated by different labs are in concordance, and can therefore be readily used by the forensic community.

    Moreover, if existing data and data generated from future experiments are made available to the (forensic) community, knowledge is needed on the key factors that underlie potential interlaboratory variation.

    The aims and objectives of this ENFSI Monopoly 2013 project are to conduct a study of methodologies and data from different laboratories and to assess the comparability of the scientific data on transfer, persistence and recovery of DNA. This comparison will allow us to identify key factors that underlie potential variation. This information will be used to setup guidelines to enable sharing and database-storage of relevant scientific

    data. This will improve the ability of forensic scientists and other professionals of the Criminal Justice System to give evidence-based answers to questions that relate to the activity level of the crime under investigation.

  • 3.
    Abafogi, Abdurhaman Teyib
    et al.
    Sungkyunkwan Univ, South Korea.
    Kim, Jaewon
    Sungkyunkwan Univ, South Korea.
    Lee, Jinyeop
    Sungkyunkwan Univ, South Korea.
    Mohammed, Merem Omer
    Sungkyunkwan Univ, South Korea.
    van Noort, Danny
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten. Univ Ljubljana, Slovenia; Univ Ingn and Tecnol UTEC, Peru.
    Park, Sungsu
    Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea.
    3D-Printed Modular Microfluidic Device Enabling Preconcentrating Bacteria and Purifying Bacterial DNA in Blood for Improving the Sensitivity of Molecular Diagnostics2020Inngår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, SENSORS, Vol. 20, nr 4, artikkel-id 1202Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Molecular diagnostics for sepsis is still a challenge due to the presence of compounds that interfere with gene amplification and bacteria at concentrations lower than the limit of detection (LOD). Here, we report on the development of a 3D printed modular microfluidic device (3Dpm mu FD) that preconcentrates bacteria of interest in whole blood and purifies their genomic DNA (gDNA). It is composed of a W-shaped microchannel and a conical microchamber. Bacteria of interest are magnetically captured from blood in the device with antibody conjugated magnetic nanoparticles (Ab-MNPs) at 5 mL/min in the W-shaped microchannel, while purified gDNA of the preconcentrated bacteria is obtained with magnetic silica beads (MSBs) at 2 mL/min in the conical microchamber. The conical microchamber was designed to be connected to the microchannel after the capturing process using a 3D-printed rotary valve to minimize the exposure of the MSBs to interfering compounds in blood. The pretreatment process of spiked blood (2.5 mL) can be effectively completed within about 50 min. With the 3Dpm mu FD, the LOD for the target microorganism Escherichia coli O157:H7 measured by both polymerase chain reaction (PCR) with electrophoresis and quantitative PCR was 10 colony forming unit (CFU) per mL of whole blood. The results suggest that our method lowers the LOD of molecular diagnostics for pathogens in blood by providing bacterial gDNA at high purity and concentration.

    Fulltekst (pdf)
    fulltext
  • 4.
    Abara, Precious Ugo
    et al.
    Univ Padua, Italy; Tech Univ Munich, Germany.
    Ticozzi, Francesco
    Univ Padua, Italy; Dartmouth Coll, NH 03755 USA.
    Altafini, Claudio
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Spectral Conditions for Stability and Stabilization of Positive Equilibria for a Class of Nonlinear Cooperative Systems2018Inngår i: IEEE Transactions on Automatic Control, ISSN 0018-9286, E-ISSN 1558-2523, Vol. 63, nr 2, s. 402-417Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nonlinear cooperative systems associated to vector fields that are concave or subhomogeneous describe well interconnected dynamics that are of key interest for communication, biological, economical, and neural network applications. For this class of positive systems, we provide conditions that guarantee existence, uniqueness and stability of strictly positive equilibria. These conditions can be formulated directly in terms of the spectral radius of the Jacobian of the system. If control inputs are available, then it is shown how to use state feedback to stabilize an equilibrium point in the interior of the positive orthant.

    Fulltekst (pdf)
    fulltext
  • 5.
    Abarghouyi, Hadis
    et al.
    IUST, Iran; MTNi Co, Iran.
    Razavizadeh, S. Mohammad
    IUST, Iran.
    Björnson, Emil
    Linköpings universitet, Institutionen för systemteknik, Kommunikationssystem. Linköpings universitet, Tekniska fakulteten.
    QoE-Aware Beamforming Design for Massive MIMO Heterogeneous Networks2018Inngår i: IEEE Transactions on Vehicular Technology, ISSN 0018-9545, E-ISSN 1939-9359, Vol. 67, nr 9, s. 8315-8323Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    One of the main goals of the future wireless networks is improving the users quality of experience (QoE). In this paper, we consider the problem of the QoE-based resource allocation in the downlink of a massive multiple-input multiple-output heterogeneous network. The network consists of a macrocell with a number of small cells embedded in it. The small cells base stations (BSs) are equipped with a few antennas, while the macro BS is equipped with a massive number of antennas. We consider the two services Video and Web Browsing and design the beamforming vectors at the BSs. The objective is to maximize the aggregated mean opinion score (MOS) of the users under constraints on the BSs powers and the required quality of service of the users. We also consider extra constraints on the QoE of users to more strongly enforce the QoE in the beamforming design. To reduce the complexity of the optimization problem, we suggest suboptimal and computationally efficient solutions. Our results illustrate that increasing the number of antennas at the BSs and also increasing the number of small cells antennas in the network leads to a higher user satisfaction.

  • 6.
    Abbas, Malik Waseem
    et al.
    Natl Inst Biotechnol and Genet Engn, Pakistan.
    Soomro, Razium Ali
    Natl Inst Biotechnol and Genet Engn, Pakistan; Univ Sindh, Pakistan; Univ Bristol, England.
    Kalwar, Nazar Hussain
    Shah Abdul Latif Univ, Pakistan.
    Zahoor, Mehvish
    Natl Inst Biotechnol and Genet Engn, Pakistan.
    Avci, Ahmet
    Selcuk Univ, Turkey.
    Pehlivan, Erol
    Selcuk Univ, Turkey.
    Hallam, Keith Richard
    Univ Bristol, England.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik, elektroteknik och matematik. Linköpings universitet, Tekniska fakulteten.
    Carbon quantum dot coated Fe3O4 hybrid composites for sensitive electrochemical detection of uric acid2019Inngår i: Microchemical journal (Print), ISSN 0026-265X, E-ISSN 1095-9149, Vol. 146, s. 517-524Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The study explores carbon quantum dots (C-dots) as potential candidates for enhancing the signal sensitivity of an electrochemical sensor devised for biologically important molecule, such as uric acid (UA). The C-dots were evaluated for their electrochemical characteristics in combination with Fe3O4 nanoparticles (Fe3O4 NPs), which were applied as the primary electro-catalytic promoter. The hybrid nanocomposite (C-dots/Fe3O4 HCs) formation was achieved by facilitating the adsorption of C-dots over Fe3O4 NPs using amine-carbonyl interactions. Unlike, one pot method, the proposed strategy enables aggregation-free coverage of Fe3O4 NPs with highly conductive layer of C-dots that can act as conduction centres to support ultra-fast electron transfer kinetics to satisfy the need of high signal sensitivity. The hybrid composite demonstrated remarkable signal improvement when tested against the electrochemical oxidation of UA. The heighten current response and lower over-potential values enabled development of a DC-amperometric (DC-AMP) sensor for UA with a linear working range of 0.01 to 0.145 mu M and signal sensitivity measurable up to 6.0 x 10(-9) M. The said improvement was manifested as a synergetic outcome of active redox couple (Fe (III/II)), larger surface area of Fe3O4 NPs engulfed with a layer of highly conductive C-dots acting as efficient charge sensitisers.

  • 7.
    Abbas, Zaheer
    et al.
    Beijing Univ Chem Technol, Peoples R China.
    Soomro, Razium Ali
    Beijing Univ Chem Technol, Peoples R China; Beijing Univ Chem Technol, Peoples R China.
    Kalwar, Nazar Hussain
    Shah Abdul Latif Univ Khairpur, Pakistan.
    Tunesi, Mawada
    Beijing Univ Chem Technol, Peoples R China.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik, elektroteknik och matematik. Linköpings universitet, Tekniska fakulteten.
    Karakus, Selcan
    Istanbul Univ Cerrahpa Avcilar, Turkey.
    Kilislioglu, Ayben
    Istanbul Univ Cerrahpa Avcilar, Turkey.
    In Situ Growth of CuWO4 Nanospheres over Graphene Oxide for Photoelectrochemical (PEC) Immunosensing of Clinical Biomarker2020Inngår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, SENSORS, Vol. 20, nr 1, artikkel-id 148Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Procalcitonin (PCT) protein has recently been identified as a clinical marker for bacterial infections based on its better sepsis sensitivity. Thus, an increased level of PCT could be linked with disease diagnosis and therapeutics. In this study, we describe the construction of the photoelectrochemical (PEC) PCT immunosensing platform based on it situ grown photo-active CuWO4 nanospheres over reduced graphene oxide layers (CuWO4@rGO). The in situ growth strategy enabled the formation of small nanospheres (diameter of 200 nm), primarily composed of tiny self-assembled CuWO4 nanoparticles (2-5 nm). The synergic coupling of CuWO4 with rGO layers constructed an excellent photo-active heterojunction for photoelectrochemical (PEC) sensing. The platform was then considered for electrocatalytic (EC) mechanism-based detection of PCT, where inhibition of the photocatalytic oxidation signal of ascorbic acid (AA), subsequent to the antibody-antigen interaction, was recorded as the primary signal response. This inhibition detection approach enabled sensitive detection of PCT in a concentration range of 10 pgmL(-1) to 50 ng.mL(-1) with signal sensitivity achievable up to 0.15 pgmL(-1). The proposed PEC hybrid (CuWO4@rGO) could further be engineered to detect other clinically important species.

    Fulltekst (pdf)
    fulltext
  • 8.
    Abbey-Lee, Robin
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. Max Planck Inst Ornithol, Germany.
    Araya-Ajoy, Yimen G.
    Norwegian Univ Sci and Technol, Norway.
    Mouchet, Alexia
    Max Planck Inst Ornithol, Germany.
    Moiron, Maria
    Max Planck Inst Ornithol, Germany.
    Stuber, Erica F.
    Univ Nebraska Lincoln, NE USA.
    Kempenaers, Bart
    Max Planck Inst Ornithol, Germany.
    Dingemanse, Niels J.
    Max Planck Inst Ornithol, Germany; Ludwig Maximilians Univ Munchen, Germany.
    Does perceived predation risk affect patterns of extra-pair paternity? A field experiment in a passerine bird2018Inngår i: Functional Ecology, ISSN 0269-8463, E-ISSN 1365-2435, Vol. 32, nr 4, s. 1001-1010Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Non-consumptive predator effects have been shown to influence a wide range of behavioural, life history and morphological traits. Extra-pair reproduction is widespread among socially monogamous birds and may incur predation costs. Consequently, altered rates of extra-pair reproduction are expected in circumstances characterized by increased adult perceived predation risk. In addition, extra-pair reproduction is expected to be most affected for birds with phenotypes that generally increase predation risk (such as more active individuals). In two consecutive years, perceived predation risk was manipulated for great tits Parus major breeding in 12 nest-box plots by broadcasting sounds of their main predator (European sparrowhawk Accipiter nisus; six plots). As a control treatment, sounds of a sympatric, avian non-predator species were broadcast (Eurasian blackbird Turdus merula; six plots). Levels of extra-pair paternity did not differ between plots with different predation risk treatments. Males that moved more in a novel environment (more active or faster exploring) tended to have offspring with fewer partners, but this effect did not vary with predation risk treatment. From an adaptive viewpoint, predation costs associated with extra-pair reproduction may be small and may not outweigh the benefits of extra-pair behaviour. Research on a broader range of taxa with different mating strategies is now needed to confirm the generality of our findings.

  • 9.
    Abbey-Lee, Robin
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. Max Planck Inst Ornithol, Germany.
    Dingemanse, Niels J.
    Ludwig Maximilians Univ Munchen, Germany.
    Adaptive individual variation in phenological responses to perceived predation levels2019Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, artikkel-id 1601Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The adaptive evolution of timing of breeding (a component of phenology) in response to environmental change requires individual variation in phenotypic plasticity for selection to act upon. A major question is what processes generate this variation. Here we apply multi-year manipulations of perceived predation levels (PPL) in an avian predator-prey system, identifying phenotypic plasticity in phenology as a key component of alternative behavioral strategies with equal fitness payoffs. We show that under low-PPL, faster (versus slower) exploring birds breed late (versus early); the pattern is reversed under high-PPL, with breeding synchrony decreasing in conjunction. Timing of breeding affects reproductive success, yet behavioral types have equal fitness. The existence of alternative behavioral strategies thus explains variation in phenology and plasticity in reproductive behavior, which has implications for evolution in response to anthropogenic change.

    Fulltekst (pdf)
    fulltext
  • 10.
    Abbey-Lee, Robin N.
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Kreshchenko, Anastasia
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Fernandez Sala, Xavier
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Petkova, Irina
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Løvlie, Hanne
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks2019Dataset
    Abstract [en]

    Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been implicated in correlations with physiological functions as well as affecting fitness-related traits. Variation in many aspects of monoamine systems, such as metabolite levels and gene polymorphisms, has been linked to behavioral variation. Therefore, here we investigated the potential role of monoamines in explaining individual variation in personality, using two common pharmaceuticals that respectively alter the levels of serotonin and dopamine in the brain: fluoxetine and ropinirole. We exposed three- spined sticklebacks, a species that shows animal personality, to either chemical alone or to a combination of the two chemicals, for 18 days. During the experiment, fish were assayed at four time points for the following personality traits: exploration, boldness, aggression and sociability. To quantify brain gene expression on short- and longer-term scales, fish were sampled at two time points. Our results show that monoamine manipulations influence fish behavior. Specifically, fish exposed to either fluoxetine or ropinirole were significantly bolder, and fish exposed to the two chemicals together tended to be bolder than control fish. Our monoamine manipulations did not alter the gene expression of monoamine or stress-associated neurotransmitter genes, but control, untreated fish showed covariation between gene expression and behavior. Specifically, exploration and boldness were predicted by genes in the dopaminergic, serotonergic and stress pathways, and sociability was predicted by genes in the dopaminergic and stress pathways. These results add further support to the links between monoaminergic systems and personality, and show that exposure to monoamines can causally alter animal personality.

    Fulltekst (xlsx)
    Raw Data
  • 11.
    Abbey-Lee, Robin N.
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Kreshchenko, Anastasia
    Mechanical and Aeronautical Engineering Division L5, Department of Mechanical, Aerospace & Civil Engineering, Dalton Nuclear Institute, FSE Research Institutes,The University of Manchester, UK.
    Fernandez Sala, Xavier
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten.
    Petkova, Irina
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. School of Biological Sciences, Centre for Ecology,Evolution and Behaviour, Royal Holloway University of London, Egham UK.
    Løvlie, Hanne
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks2019Inngår i: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 222, nr 20, artikkel-id jeb211888Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been correlated with physiological functions as well as fitness-related traits. Variation in many aspects of monoamine systems, such as metabolite levels and gene polymorphisms, has been linked to behavioral variation. Therefore, here we experimentally investigated the potential role of monoamines in explaining individual variation in personality, using two common pharmaceuticals that respectively alter the levels of serotonin and dopamine in the brain: fluoxetine and ropinirole. We exposed three-spined sticklebacks, a species that shows animal personality, to either chemical alone or to a combination of the two chemicals, for 18 days. During the experiment, fish were assayed at four time points for the following personality traits: exploration, boldness, aggression and sociability. To quantify brain gene expression on short- and longer-term scales, fish were sampled at two time points. Our results show that monoamine manipulations influence fish behavior. Specifically, fish exposed to either fluoxetine or ropinirole were significantly bolder, and fish exposed to the two chemicals together tended to be bolder than control fish. Our monoamine manipulations did not alter the gene expression of monoamine or stress-associated neurotransmitter genes, but control, untreated fish showed covariation between gene expression and behavior. Specifically, exploration and boldness were predicted by genes in the dopaminergic, serotonergic and stress pathways, and sociability was predicted by genes in the dopaminergic and stress pathways. These results add further support to the links between monoaminergic systems and personality, and show that exposure to monoamines can causally alter animal personality.

    Fulltekst (pdf)
    fulltext
  • 12.
    Abbey-Lee, Robin N.
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Uhrig, Emily J.
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden.
    Zidar, Josefina
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Favati, Anna
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden.
    Almberg, Johan
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Dahlblom, Josefin
    Department of Neuroscience, Uppsala Biomedical Centre BMC, Uppsala University, Uppsala, Sweden.
    Winberg, Svante
    Department of Neuroscience, Uppsala Biomedical Centre BMC, Uppsala University, Uppsala, Sweden.
    Løvlie, Hanne
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    The influence of rearing on behavior, brain monoamines and gene expression in three-spined sticklebacks2018Dataset
    Abstract [en]
    1. The causes of individual variation in behavior are often not well understood, and potential underlying mechanisms include both intrinsic and extrinsic factors, such as early environmental, physiological, and genetic differences.
    2. In an exploratory laboratory study, we raised three-spined sticklebacks (Gasterosteus aculeatus) under 4 different environmental conditions (simulated predator environment, complex environment, variable social environment, and control). We investigated how these manipulations related to behavior, brain physiology and gene expression later in life, with focus on brain dopamine and serotonin levels, turnover rates, and gene expression.
    3. The different rearing environments influenced behavior and gene expression, but did not alter monoamine levels or metabolites. Specifically, compared to control fish, fish exposed to a simulated predator environment tended to be less aggressive, more exploratory, and more neophobic; and fish raised in both complex and variable social environments tended to be less neophobic. Exposure to a simulated predator environment tended to lower expression of dopamine receptor DRD4A, a complex environment increased expression of dopamine receptor DRD1B, while a variable social environment tended to increase serotonin receptor 5-HTR2B and increased serotonin transporter SLC6A4A expression. Despite both behavior and gene expression varying with early environment, there was no evidence that gene expression mediated the relationship between early environment and behavior.
    4. Our results confirm that environmental conditions early in life can affect phenotypic variation. However, the mechanistic pathway of the monoaminergic systems translating early environmental variation into observed behavioral responses was not detected.
    Fulltekst (xlsx)
    dataset
  • 13.
    Abbey-Lee, Robin N.
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Uhrig, Emily
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Zidar, Josefina
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Favati, A.
    Department of Zoology, Stockholm University, Stockholm, Sweden.
    Almberg, J.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Dahlbom, J.
    Department of Neuroscience, Uppsala Biomedical Centre BMC, Uppsala University, Uppsala, Sweden.
    Winberg, S.
    Department of Neuroscience, Uppsala Biomedical Centre BMC, Uppsala University, Uppsala, Sweden.
    Løvlie, Hanne
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    The Influence of Rearing on Behavior, Brain Monoamines, and Gene Expression in Three-Spined Sticklebacks2018Inngår i: Brain, behavior, and evolution, ISSN 0006-8977, E-ISSN 1421-9743, Vol. 91, nr 4, s. 201-213Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The causes of individual variation in behavior are often not well understood, and potential underlying mechanisms include both intrinsic and extrinsic factors, such as early environmental, physiological, and genetic differences. In an exploratory laboratory study, we raised three-spined sticklebacks <i>(Gasterosteus aculeatus)</i> under 4 different environmental conditions (simulated predator environment, complex environment, variable social environment, and control). We investigated how these manipulations related to behavior, brain physiology, and gene expression later in life, with focus on brain dopamine and serotonin levels, turnover rates, and gene expression. The different rearing environments influenced behavior and gene expression, but did not alter monoamine levels or metabolites. Specifically, compared to control fish, fish exposed to a simulated predator environment tended to be less aggressive, more exploratory, and more neophobic; and fish raised in both complex and variable social environments tended to be less neophobic. Exposure to a simulated predator environment tended to lower expression of dopamine receptor DRD4A, a complex environment increased expression of dopamine receptor DRD1B, while a variable social environment tended to increase serotonin receptor 5-HTR2B and serotonin transporter SLC6A4A expression. Despite both behavior and gene expression varying with early environment, there was no evidence that gene expression mediated the relationship between early environment and behavior. Our results confirm that environmental conditions early in life can affect phenotypic variation. However, the mechanistic pathway of the monoaminergic systems translating early environmental variation into observed behavioral responses was not detected.

    Fulltekst (pdf)
    fulltext
  • 14.
    Abbey-Lee, Robin
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Uhrig, Emily
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. Southern Oregon Univ, OR 97520 USA.
    Garnham, Laura
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Lundgren, Kristoffer
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Child, Sarah
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. Univ Manchester, England.
    Lovlie, Hanne
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Experimental manipulation of monoamine levels alters personality in crickets2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 16211Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Animal personality has been described in a range of species with ecological and evolutionary consequences. Factors shaping and maintaining variation in personality are not fully understood, but monoaminergic systems are consistently linked to personality variation. We experimentally explored how personality was influenced by alterations in two key monoamine systems: dopamine and serotonin. This was done using ropinirole and fluoxetine, two common human pharmaceuticals. Using the Mediterranean field cricket (Gryllus bimaculatus), we focused on the personality traits activity, exploration, and aggression, with confirmed repeatability in our study. Dopamine manipulations explained little variation in the personality traits investigated, while serotonin manipulation reduced both activity and aggression. Due to limited previous research, we created a dose-response curve for ropinirole, ranging from concentrations measured in surface waters to human therapeutic doses. No ropinirole dose level strongly influenced cricket personality, suggesting our results did not come from a dose mismatch. Our results indicate that the serotonergic system explains more variation in personality than manipulations of the dopaminergic system. Additionally, they suggest that monoamine systems differ across taxa, and confirm the importance of the mode of action of pharmaceuticals in determining their effects on behaviour.

    Fulltekst (pdf)
    fulltext
  • 15.
    Abbott, Rebecca
    et al.
    Northwestern Univ, IL 60611 USA.
    Peolsson, Anneli
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för fysioterapi. Linköpings universitet, Medicinska fakulteten.
    West, Janne
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Medicinska fakulteten.
    Elliott, James M.
    Northwestern Univ, IL 60611 USA; Univ Queensland, Australia; Zurich Univ Appl Sci, Switzerland.
    Åslund, Ulrika
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för fysioterapi. Linköpings universitet, Medicinska fakulteten.
    Karlsson, Anette
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Dahlqvist Leinhard, Olof
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    The qualitative grading of muscle fat infiltration in whiplash using fat and water magnetic resonance imaging2018Inngår i: The spine journal, ISSN 1529-9430, E-ISSN 1878-1632, Vol. 18, nr 5, s. 717-725Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND CONTEXT: The development of muscle fat infiltration (MFI) in the neck muscles is associated with poor functional recovery following whiplash injury. Custom software and time-consuming manual segmentation of magnetic resonance imaging (MRI) is required for quantitative analysis and presents as a barrier for clinical translation. PURPOSE: The purpose of this work was to establish a qualitative MRI measure for MFI and evaluate its ability to differentiate between individuals with severe whiplash-associated disorder (WAD), mild or moderate WAD, and healthy controls. STUDY DESIGN/SETTING: This is a cross-sectional study. PATIENT SAMPLE: Thirty-one subjects with WAD and 31 age-and sex-matched controls were recruited from an ongoing randomized controlled trial. OUTCOME MEASURES: The cervical multifidus was visually identified and segmented into eighths in the axial fat/water images (C4-C7). Muscle fat infiltration was assessed on a visual scale: 0 for no or marginal MFI, 1 for light MFI, and 2 for distinct MFI. The participants with WAD were divided in two groups: mild or moderate and severe based on Neck Disability Index % scores. METHODS: The mean regional MFI was compared between the healthy controls and each of the WAD groups using the Mann-Whitney U test. Receiver operator characteristic (ROC) analyses were carried out to evaluate the validity of the qualitative method. RESULTS: Twenty (65%) patients had mild or moderate disability and 11 (35%) were considered severe. Inter- and intra-rater reliability was excellent when grading was averaged by level or when frequency of grade II was considered. Statistically significant differences (pamp;lt;.05) in regional MFI were particularly notable between the severe WAD group and healthy controls. The ROC curve, based on detection of distinct MFI, showed an area-under-the curve of 0.768 (95% confidence interval 0.59-0.94) for discrimination of WAD participants. CONCLUSIONS: These preliminary results suggest a qualitative MRI measure for MFI is reliable and valid, and may prove useful toward the classification of WAD in radiology practice. (C) 2017 Elsevier Inc. All rights reserved.

  • 16. Bestill onlineKjøp publikasjonen >>
    Abdalla, Hassan
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Charge and Energy Transport in Disordered Organic Semiconductors2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Improvement of the performance of organic disordered semiconductors (OSC) is driven by the understanding   of the underlying charge transport mechanisms and systematic exploitation thereof. There exists a multitude of materials and material systems based on polymers and small molecules with promising performance for use in organic light emitting diodes, photovoltaics, organic field-effect transistors and thermoelectrics. However, universal understanding of many classes of these materials has eluded researchers, due to their broad   spectrum of morphologies, molecular structures and electrical properties. Building on the large body of existing models, this thesis deals with charge transport phenomena from the perspective of transport energetics, by studying the interplay between a few but important concepts commonly accepted to play a crucial role in all  OSC materials; energetic disorder, charge carrier hopping and Coulomb interactions. The influence of these concepts on the energetic landscape through which charge carriers move and how this translates to experimentally observed transport phenomena are studied by a combination of experimental work, kinetic Monte Carlo (MC) simulations and empirical and analytical models.

    The universal scaling and collapse of the temperature and electric field dependence of the conductivity of PEDOT:PSS to a single curve is shown to be functionally equivalent to the scaling of the effective temperature, which describes the effect of field heating as a broadening of the charge carrier distribution. From numerical investigation of the energy relaxation, an empirical model is developed that relates the physical meaning   behind both concepts to the heat balance between Joule heating of the carrier distribution via the effective temperature and energy loss to the lattice. For this universal description to be applicable a strongly energy- dependent density of states (DOS) as well as Coulomb interactions and large carrier concentrations are needed.

    Chemical doping is a common way of improving charge transport in OSC and is also beneficial for energy transport, which combined leads to an increased thermoelectric power factor. The ensuing thermoelectric investigations not only showed the potential of these materials for use in thermoelectric generators, but are  also helpful in unraveling charge transport mechanism as they give direct insight into the energetics of a material. Interestingly, doped OSC exhibit the same universal power-law relationship between thermopower and conductivity, independent of material system or doping method, pointing towards a common energy and charge transport mechanism. In this thesis an analytical model is presented, which reproduces said universal power-law behavior and is able to attribute it to Variable Range Hopping (VRH) or a transition between Nearest Neighbour Hopping (NNH) and VRH at higher concentrations. This model builds on an existing three- dimensional hopping formalism that includes the effect of the attractive Coulomb potential of ionized dopants that leads to a broadening of the DOS. Here, this model is extended by including the energy offset between   host and dopant material and is positively tested against MC simulations and a set of thermoelectric measurements covering different material groups and doping mechanisms.

    Organic field effect transistors (OFETs) have become increasingly comparable in electrical mobility to their inorganic (silicon) counterparts. The spatial extent of charge transport in OFETs has been subject to debate since their inception with many experimental, numerical and analytical studies having been undertaken. Here it is shown that the common way of analyzing the dimensionality of charge transport in OFETs may be prone to misinterpretations. Instead, the results in this thesis suggest that charge transport in OFETs is, in fact, quasi- two-dimensional (2D) due to the confinement of the gate field in addition to a morphology-induced preferred in-plane direction of the transport. The inherently large charge carrier concentrations in OFETs in addition to   the quasi-2D confinement leads to increased Coulomb interaction between charge carriers as compared to bulk material, leading to a thermoelectric behavior that deviates from doped organic systems. At very large concentrations interesting charge transport phenomena are observed, including an unexpected simultaneous increase of the concentration dependence and the magnitude of the mobility, the appearance of a negative transconductance, indicating a transition to an insulating Mott-Hubbard phase. The experimental and   numerical results in this thesis relate these phenomena the intricacies of the interplay between Coulomb interactions, energetic disorder and charge carrier hopping.

    Delarbeid
    1. Effective Temperature and Universal Conductivity Scaling in Organic Semiconductors
    Åpne denne publikasjonen i ny fane eller vindu >>Effective Temperature and Universal Conductivity Scaling in Organic Semiconductors
    2015 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, artikkel-id 16870Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    We investigate the scalability of the temperature-and electric field-dependence of the conductivity of disordered organic semiconductors to universal curves by two different but commonly employed methods; by so-called universal scaling and by using the effective temperature concept. Experimentally both scaling methods were found to be equally applicable to the out-of-plane charge transport in PEDOT: PSS thin films of various compositions. Both methods are shown to be equivalent in terms of functional dependence and to have identical limiting behavior. The experimentally observed scaling behavior can be reproduced by a numerical nearest-neighbor hopping model, accounting for the Coulomb interaction, the high charge carrier concentration and the energetic disorder. The underlying physics can be captured in a simple empirical model, describing the effective temperature of the charge carrier distribution as the outcome of a heat balance between Joule heating and (effective) temperature-dependent energy loss to the lattice.

    sted, utgiver, år, opplag, sider
    Nature Publishing Group, 2015
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-123329 (URN)10.1038/srep16870 (DOI)000364933800002 ()26581975 (PubMedID)
    Tilgjengelig fra: 2015-12-14 Laget: 2015-12-11 Sist oppdatert: 2019-09-26
    2. Impact of doping on the density of states and the mobility in organic semiconductors
    Åpne denne publikasjonen i ny fane eller vindu >>Impact of doping on the density of states and the mobility in organic semiconductors
    2016 (engelsk)Inngår i: PHYSICAL REVIEW B, ISSN 2469-9950, Vol. 93, nr 23, s. 235203-Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    We experimentally investigated conductivity and mobility of poly(3-hexylthiophene) (P3HT) doped with tetrafluorotetracyanoquinodimethane (F(4)TCNQ) for various relative doping concentrations ranging from ultralow (10(-5)) to high (10(-1)) and various active layer thicknesses. Although the measured conductivity monotonously increases with increasing doping concentration, the mobilities decrease, in agreement with previously published work. Additionally, we developed a simple yet quantitative model to rationalize the results on basis of a modification of the density of states (DOS) by the Coulomb potentials of ionized dopants. The DOS was integrated in a three-dimensional (3D) hopping formalism in which parameters such as energetic disorder, intersite distance, energy level difference, and temperature were varied. We compared predictions of our model as well as those of a previously developed model to kinetic Monte Carlo (MC) modeling and found that only the former model accurately reproduces the mobility of MC modeling in a large part of the parameter space. Importantly, both our model and MC simulations are in good agreement with experiments; the crucial ingredient to both is the formation of a deep trap tail in the Gaussian DOS with increasing doping concentration.

    sted, utgiver, år, opplag, sider
    AMER PHYSICAL SOC, 2016
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-130276 (URN)10.1103/PhysRevB.93.235203 (DOI)000378813800009 ()
    Merknad

    Funding Agencies|Chinese Scholarship Council (CSC)

    Tilgjengelig fra: 2016-08-01 Laget: 2016-07-28 Sist oppdatert: 2018-08-29
    3. Range and energetics of charge hopping in organic semiconductors
    Åpne denne publikasjonen i ny fane eller vindu >>Range and energetics of charge hopping in organic semiconductors
    2017 (engelsk)Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 96, nr 24, artikkel-id 241202Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    The recent upswing in attention for the thermoelectric properties of organic semiconductors (OSCs) adds urgency to the need for a quantitative description of the range and energetics of hopping transport in organic semiconductors under relevant circumstances, i.e., around room temperature (RT). In particular, the degree to which hops beyond the nearest neighbor must be accounted for at RT is still largely unknown. Here, measurements of charge and energy transport in doped OSCs are combined with analytical modeling to reach the univocal conclusion that variable-range hopping is the proper description in a large class of disordered OSC at RT. To obtain quantitative agreement with experiment, one needs to account for the modification of the density of states by ionized dopants. These Coulomb interactions give rise to a deep tail of trap states that is independent of the materials initial energetic disorder. Insertion of this effect into a classical Mott-type variable-range hopping model allows one to give a quantitative description of temperature-dependent conductivity and thermopower measurements on a wide range of disordered OSCs. In particular, the model explains the commonly observed quasiuniversal power-law relation between the Seebeck coefficient and the conductivity.

    sted, utgiver, år, opplag, sider
    AMER PHYSICAL SOC, 2017
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-144143 (URN)10.1103/PhysRevB.96.241202 (DOI)000418616700001 ()
    Merknad

    Funding Agencies|Chinese Scholarship Council (CSC); Knut och Alice Wallenberg stiftelse

    Tilgjengelig fra: 2018-01-10 Laget: 2018-01-10 Sist oppdatert: 2018-08-29
    4. Investigation of the dimensionality of charge transport in organic field effect transistors
    Åpne denne publikasjonen i ny fane eller vindu >>Investigation of the dimensionality of charge transport in organic field effect transistors
    2017 (engelsk)Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 95, nr 8, artikkel-id 85301Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Ever since the first experimental investigations of organic field effect transistors (OFETs) the dimensionality of charge transport has alternately been described as two dimensional (2D) and three dimensional (3D). More recently, researchers have turned to an analytical analysis of the temperature-dependent transfer characteristics to classify the dimensionality as either 2D or 3D as well as to determine the disorder of the system, thereby greatly simplifying dimensionality investigations. We applied said analytical analysis to the experimental results of our OFETs comprising molecularly well-defined polymeric layers as the active material as well as to results obtained from kinetic Monte Carlo simulations and found that it was not able to correctly distinguish between 2D and 3D transports or give meaningful values for the disorder and should only be used for quasiquantitative and comparative analysis. We conclude to show that the dimensionality of charge transport in OFETs is a function of the interplay between transistor physics and morphology of the organic material.

    sted, utgiver, år, opplag, sider
    AMER PHYSICAL SOC, 2017
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-138929 (URN)10.1103/PhysRevB.95.085301 (DOI)000402194500006 ()
    Merknad

    Funding Agencies|Knut och Alice Wallenbergs stiftelse; Advanced Functional Materials Center at Linkoping University [2009-00971]; VINNOVA [2015-04859]

    Tilgjengelig fra: 2017-06-27 Laget: 2017-06-27 Sist oppdatert: 2018-03-14
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    Charge and Energy Transport in Disordered Organic Semiconductors
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  • 17.
    Abdalla, Hassan
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Fabiano, Simone
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Kemerink, Martijn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Investigation of the dimensionality of charge transport in organic field effect transistors2017Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 95, nr 8, artikkel-id 85301Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Ever since the first experimental investigations of organic field effect transistors (OFETs) the dimensionality of charge transport has alternately been described as two dimensional (2D) and three dimensional (3D). More recently, researchers have turned to an analytical analysis of the temperature-dependent transfer characteristics to classify the dimensionality as either 2D or 3D as well as to determine the disorder of the system, thereby greatly simplifying dimensionality investigations. We applied said analytical analysis to the experimental results of our OFETs comprising molecularly well-defined polymeric layers as the active material as well as to results obtained from kinetic Monte Carlo simulations and found that it was not able to correctly distinguish between 2D and 3D transports or give meaningful values for the disorder and should only be used for quasiquantitative and comparative analysis. We conclude to show that the dimensionality of charge transport in OFETs is a function of the interplay between transistor physics and morphology of the organic material.

    Fulltekst (pdf)
    fulltext
  • 18.
    Abdalla, Hassan
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    van de Ruit, Kevin
    Eindhoven University of Technology, Netherlands.
    Kemerink, Martijn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten. Eindhoven University of Technology, Netherlands.
    Effective Temperature and Universal Conductivity Scaling in Organic Semiconductors2015Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, artikkel-id 16870Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We investigate the scalability of the temperature-and electric field-dependence of the conductivity of disordered organic semiconductors to universal curves by two different but commonly employed methods; by so-called universal scaling and by using the effective temperature concept. Experimentally both scaling methods were found to be equally applicable to the out-of-plane charge transport in PEDOT: PSS thin films of various compositions. Both methods are shown to be equivalent in terms of functional dependence and to have identical limiting behavior. The experimentally observed scaling behavior can be reproduced by a numerical nearest-neighbor hopping model, accounting for the Coulomb interaction, the high charge carrier concentration and the energetic disorder. The underlying physics can be captured in a simple empirical model, describing the effective temperature of the charge carrier distribution as the outcome of a heat balance between Joule heating and (effective) temperature-dependent energy loss to the lattice.

    Fulltekst (pdf)
    fulltext
  • 19.
    Abdalla, Hassan
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Zuo, Guangzheng
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Kemerink, Martijn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Range and energetics of charge hopping in organic semiconductors2017Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 96, nr 24, artikkel-id 241202Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The recent upswing in attention for the thermoelectric properties of organic semiconductors (OSCs) adds urgency to the need for a quantitative description of the range and energetics of hopping transport in organic semiconductors under relevant circumstances, i.e., around room temperature (RT). In particular, the degree to which hops beyond the nearest neighbor must be accounted for at RT is still largely unknown. Here, measurements of charge and energy transport in doped OSCs are combined with analytical modeling to reach the univocal conclusion that variable-range hopping is the proper description in a large class of disordered OSC at RT. To obtain quantitative agreement with experiment, one needs to account for the modification of the density of states by ionized dopants. These Coulomb interactions give rise to a deep tail of trap states that is independent of the materials initial energetic disorder. Insertion of this effect into a classical Mott-type variable-range hopping model allows one to give a quantitative description of temperature-dependent conductivity and thermopower measurements on a wide range of disordered OSCs. In particular, the model explains the commonly observed quasiuniversal power-law relation between the Seebeck coefficient and the conductivity.

  • 20.
    Abdallah, Nancy
    et al.
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik.
    Hansson, Mikael
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Hultman, Axel
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Topology of posets with special partial matchings2019Inngår i: Advances in Mathematics, ISSN 0001-8708, E-ISSN 1090-2082, Vol. 348, s. 255-276Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Special partial matchings (SPMs) are a generalisation of Brentis special matchings. Let a pircon be a poset in which every non-trivial principal order ideal is finite and admits an SPM. Thus pircons generalise Mariettis zircons. We prove that every open interval in a pircon is a PL ball or a PL sphere. It is then demonstrated that Bruhat orders on certain twisted identities and quasiparabolic W-sets constitute pircons. Together, these results extend a result of Can, Cherniaysky, and Twelbeck, prove a conjecture of Hultman, and confirm a claim of Rains and Vazirani.

  • 21.
    Abdallah, Nancy
    et al.
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Hultman, Axel
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    Combinatorial invariance of Kazhdan-Lusztig-Vogan polynomials for fixed point free involutions2018Inngår i: Journal of Algebraic Combinatorics, ISSN 0925-9899, E-ISSN 1572-9192, Vol. 47, nr 4, s. 543-560Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    When acts on the flag variety of , the orbits are in bijection with fixed point free involutions in the symmetric group . In this case, the associated Kazhdan-Lusztig-Vogan polynomials can be indexed by pairs of fixed point free involutions , where denotes the Bruhat order on . We prove that these polynomials are combinatorial invariants in the sense that if is a poset isomorphism of upper intervals in the Bruhat order on fixed point free involutions, then for all v amp;gt;= u.

    Fulltekst (pdf)
    fulltext
  • 22.
    Abdelfattah, Ahmed
    et al.
    Univ Mediterranea Reggio Calabria, Italy.
    Malacrinò, Antonino
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Wisniewski, Michael
    USDA ARS, WV 25430 USA.
    Cacciola, Santa O.
    Univ Catania, Italy.
    Schena, Leonardo
    Univ Mediterranea Reggio Calabria, Italy.
    Metabarcoding: A powerful tool to investigate microbial communities and shape future plant protection strategies2018Inngår i: Biological control (Print), ISSN 1049-9644, E-ISSN 1090-2112, Vol. 120Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Microorganisms are the main drivers shaping the functioning and equilibrium of all ecosystems, contributing to nutrient cycling, primary production, litter decomposition, and multi-trophic interactions. Knowledge about the microbial assemblies in specific ecological niches is integral to understanding the assemblages interact and function the function, and becomes essential when the microbiota intersects with human activities, such as protecting crops against pests and diseases. Metabarcoding has proven to be a valuable tool and has been widely used for characterizing the microbial diversity of different environments and has been utilized in many research endeavors. Here we summarize the current status of metabarcoding technologies, the advantages and challenges in utilizing this technique, and how this pioneer approach is being applied to studying plant diseases and pests, with a focus on plant protection and biological control. Current and future developments in this technology will foster a more comprehensive understanding of microbial ecology, and the development of new, innovative pest control strategies.

  • 23.
    Abd-Elmagid, Mohamed A.
    et al.
    Virginia Tech, VA 24061 USA.
    Pappas, Nikolaos
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Kommunikations- och transportsystem. Linköpings universitet, Tekniska fakulteten.
    Dhillon, Arpreet S.
    Virginia Tech, VA 24061 USA.
    On the Role of Age of Information in the Internet of Things2019Inngår i: IEEE Communications Magazine, ISSN 0163-6804, E-ISSN 1558-1896, Vol. 57, nr 12, s. 72-77Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this article, we provide an accessible introduction to the emerging idea of Age of Information (AoI) that quantifies freshness of information and explore its possible role in the efficient design of freshness-aware Internet of Things (IoT). We start by summarizing the concept of AoI and its variants with emphasis on the differences between AoI and other well-known performance metrics in the literature, such as throughput and delay. Building on this, we explore freshness-aware IoT design for a network in which IoT devices sense potentially different physical processes and are supposed to frequently update the status of these processes at a destination node (e.g., a cellular base station). Inspired by recent interest, we also assume that these IoT devices are powered by wireless energy transfer by the destination node. For this setting, we investigate the optimal sampling policy that jointly optimizes wireless energy transfer and scheduling of update packet transmissions from IoT devices with the goal of minimizing long-term weighted sum-AoI. Using this, we characterize the achievable AoI region. We also compare this AoI-optimal policy with the one that maximizes average throughput (throughput-optimal policy), and demonstrate the impact of system state on their structures. Several promising directions for future research are also presented.

    Fulltekst (pdf)
    fulltext
  • 24.
    Abdollahi Sani, Negar
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska fakulteten.
    Mirbel, Deborah
    Univ Bordeaux, France.
    Fabiano, Simone
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Simon, Daniel
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Engquist, Isak
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Brochon, Cyril
    Univ Bordeaux, France.
    Cloutet, Eric
    Univ Bordeaux, France.
    Hadziioannou, Georges
    Univ Bordeaux, France.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    A ferroelectric polymer introduces addressability in electrophoretic display cells2019Inngår i: FLEXIBLE AND PRINTED ELECTRONICS, ISSN 2058-8585, Vol. 4, nr 3, artikkel-id 035004Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    During the last decades, tremendous efforts have been carried out to develop flexible electronics for a vast array of applications. Among all different applications investigated in this area, flexible displays have gained significant attention, being a vital part of large-area devices, portable systems and electronic labels etc electrophoretic (EP) ink displays have outstanding properties such as a superior optical switch contrast and low power consumption, besides being compatible with flexible electronics. However, the EP ink technology requires an active matrix-addressing scheme to enable exclusive addressing of individual pixels. EP ink pixels cannot be incorporated in low cost and easily manufactured passive matrix circuits due to the lack of threshold voltage and nonlinearity, necessities to provide addressability. Here, we suggest a simple method to introduce nonlinearity and threshold voltage in EP ink display cells in order to make them passively addressable. Our method exploits the nonlinearity of an organic ferroelectric capacitor that introduces passive addressability in display cells. The organic ferroelectric material poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) is here chosen because of its simple manufacturing protocol and good polarizability. We demonstrate that a nonlinear EP cell with bistable states can be produced by depositing a P(VDF-TrFE) film on the bottom electrode of the display cell. The P(VDF-TrFE) capacitor and the EP ink cell are separately characterized in order to match the surface charge at their respective interfaces and to achieve and optimize bistable operation of display pixels.

    Fulltekst (pdf)
    fulltext
  • 25.
    Abdollahi Sani, Negar
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Wang, Xin
    Acreo Swedish ICT AB, Sweden.
    Granberg, Hjalmar
    INNVENTIA AB, Sweden.
    Andersson Ersman, Peter
    Acreo Swedish ICT AB, Sweden.
    Crispin, Xavier
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Dyreklev, Peter
    Acreo Swedish ICT AB, Sweden.
    Engquist, Isak
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Gustafsson, Göran
    Acreo Swedish ICT AB, Sweden.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Flexible Lamination-Fabricated Ultra-High Frequency Diodes Based on Self-Supporting Semiconducting Composite Film of Silicon Micro-Particles and Nano-Fibrillated Cellulose2016Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, nr 28921Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Low cost and flexible devices such as wearable electronics, e-labels and distributed sensors will make the future "internet of things" viable. To power and communicate with such systems, high frequency rectifiers are crucial components. We present a simple method to manufacture flexible diodes, operating at GHz frequencies, based on self-adhesive composite films of silicon micro-particles (Si-mu Ps) and glycerol dispersed in nanofibrillated cellulose (NFC). NFC, Si-mu Ps and glycerol are mixed in a water suspension, forming a self-supporting nanocellulose-silicon composite film after drying. This film is cut and laminated between a flexible pre-patterned Al bottom electrode and a conductive Ni-coated carbon tape top contact. A Schottky junction is established between the Al electrode and the Si-mu Ps. The resulting flexible diodes show current levels on the order of mA for an area of 2 mm(2), a current rectification ratio up to 4 x 10(3) between 1 and 2 V bias and a cut-off frequency of 1.8 GHz. Energy harvesting experiments have been demonstrated using resistors as the load at 900 MHz and 1.8 GHz. The diode stack can be delaminated away from the Al electrode and then later on be transferred and reconfigured to another substrate. This provides us with reconfigurable GHz-operating diode circuits.

    Fulltekst (pdf)
    fulltext
  • 26.
    Abdul Nazar, Mohamed
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Design of a Gysel Combiner at 100 MHz2019Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    This thesis relates to the design and implementation of a Gysel power combiner consisting of two input ports. The design is implemented using discrete (lumped) components over the conventional transmission line architecture and operates at 100 MHz. Because of the high power requirements for the power combiner, special attention is given to the power handling capabilities of the lumped elements and the other components involved. Simulations of an S-parameter of Gysel power combiner are performed using the Advanced Design System (ADS) from Keysight Technologies. The final design of two-way Gysel power combiner using PCB toroidal inductor was implemented, simulated and optimized at centre frequency of 100 MHz. Satisfactory results were obtained in terms of Insertion loss, Return loss and Port Isolation.

    Fulltekst (pdf)
    Design of a Gysel Combiner at 100 MHz
  • 27.
    Abdulla, Ariyan
    et al.
    Linköpings universitet, Matematiska institutionen, Optimeringslära. Linköpings universitet, Tekniska fakulteten.
    Andersson, Erik
    Linköpings universitet, Matematiska institutionen, Optimeringslära. Linköpings universitet, Tekniska fakulteten.
    Heuristiska algoritmer för schemaläggning i real-tidssystem med hänsyn till data beroenden2018Independent thesis Basic level (degree of Bachelor), 10,5 poäng / 16 hpOppgave
    Abstract [en]

    The schedule for the jobs in a real-time system can have a huge impact on how the system behave. Since real-time systems are common in safety applications it is important that the scheduling is done in a valid way. Furthermore, one can enhance the performance of the applications by minimizing data latency and jitter. A challenge is that jobs in real-time systems usually have complex constraints making it too time consuming to minimize data latency and jitter to optimality. The purpose of this report is to investigate the possibility of creating high quality schedules using heuristics, with the goal to keep the computational time under one minute. This will be done by comparing three different algorithms that will be used on real scheduling instances provided by the company Arcticus. The first algorithm is a greedy heuristic, the second one a local search and the third one is a metaheuristic, simulated annealing. The results indicate that the data latency can be reduced whilst keeping the computational time below one minute.

    Fulltekst (pdf)
    fulltext
  • 28.
    Abdulla, Parosh Aziz
    et al.
    Uppsala Univ, Sweden.
    Atig, Mohamed Faouzi
    Uppsala Univ, Sweden.
    Chen, Yu-Fang
    Acad Sinica, Taiwan.
    Phi Diep, Bui
    Uppsala Univ, Sweden.
    Holik, Lukas
    Brno Univ Technol, Czech Republic.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska fakulteten.
    Rummer, Philipp
    Uppsala Univ, Sweden.
    TRAU : SMT solver for string constraints2018Inngår i: PROCEEDINGS OF THE 2018 18TH CONFERENCE ON FORMAL METHODS IN COMPUTER AIDED DESIGN (FMCAD), IEEE , 2018, s. 165-169Konferansepaper (Fagfellevurdert)
    Abstract [en]

    We introduce TRAU, an SMT solver for an expressive constraint language, including word equations, length constraints, context-free membership queries, and transducer constraints. The satisfiability problem for such a class of constraints is in general undecidable. The key idea behind TRAU is a technique called flattening, which searches for satisfying assignments that follow simple patterns. TRAU implements a Counter-Example Guided Abstraction Refinement (CEGAR) framework which contains both an under- and an over-approximation module. The approximations are refined in an automatic manner by information flow between the two modules. The technique implemented by TRAU can handle a rich class of string constraints and has better performance than state-of-the-art string solvers.

  • 29.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University.
    Atig, Mohammed Faouzi
    Uppsala University.
    Ganjei, Zeinab
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska fakulteten.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Zhu, Yunyun
    Uppsala University.
    Verification of Cache Coherence Protocols wrt. Trace Filters2015Konferansepaper (Fagfellevurdert)
    Abstract [en]

    We address the problem of parameterized verification of cache coherence protocols for hardware accelerated transactional memories. In this setting, transactional memories leverage on the versioning capabilities of the underlying cache coherence protocol. The length of the transactions, their number, and the number of manipulated variables (i.e., cache lines) are parameters of the verification problem. Caches in such systems are finite-state automata communicating via broadcasts and shared variables. We augment our system with filters that restrict the set of possible executable traces according to existing conflict resolution policies. We show that the verification of coherence for parameterized cache protocols with filters can be reduced to systems with only a finite number of cache lines. For verification, we show how to account for the effect of the adopted filters in a symbolic backward reachability algorithm based on the framework of constrained monotonic abstraction. We have implemented our method and used it to verify transactional memory coherence protocols with respect to different conflict resolution policies.

  • 30.
    Abellán, C.
    et al.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Acín, A.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain / ICREA - Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
    Alarcón, A.
    Millennium Institute for Research in Optics, Universidad de Concepción, Universidad de Concepción, Concepción, Chile / Departamento de Ingeniería Eléctrica, Universidad de Concepción, Concepción, Chile.
    Alibart, O.
    Université Côte d’Azur, CNRS UMR 7010, Institut de Physique de Nice (INPHYNI), Nice, France.
    Andersen, C. K.
    Department of Physics, ETH Zurich,, Zurich, Switzerland.
    Andreoli, F.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Beckert, A.
    Department of Physics, ETH Zurich,, Zurich, Switzerland.
    Beduini, F. A.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Bendersky, A.
    Departamento de Computación, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Investigación en Ciencias de la Comunicación (ICC), CONICET, Buenos Aires, Argentina.
    Bentivegna, M.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Bierhorst, P.
    National Institute of Standards and Technology, Boulder, CO, USA.
    Burchardt, D.
    Ludwig-Maximilians-Universität, Munich, Germany.
    Cabello, A.
    Departamento de Física Aplicada II, Universidad de Sevilla, Seville, Spain.
    Cariñe, J.
    Millennium Institute for Research in Optics, Universidad de Concepción, Universidad de Concepción, Concepción, Chile.
    Carrasco, S.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Carvacho, G.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Cavalcanti, D.
    Chaves, R.
    Cortés-Vega, J.
    Cuevas, A.
    Delgado, A.
    de Riedmatten, H.
    Eichler, C.
    Farrera, P.
    Fuenzalida, J.
    García-Matos, M.
    Garthoff, R.
    Gasparinetti, S.
    Gerrits, T.
    Ghafari Jouneghani, F.
    Glancy, S.
    Gómez, E. S.
    González, P.
    Guan, J. -Y.
    Handsteiner, J.
    Heinsoo, J.
    Heintze, G.
    Hirschmann, A.
    Jiménez, O.
    Kaiser, F.
    Knill, E.
    Knoll, L. T.
    Krinner, S.
    Kurpiers, P.
    Larotonda, M. A.
    Larsson, Jan-Åke
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska fakulteten.
    Lenhard, A.
    Li, H.
    Li, M. -H.
    Lima, G.
    Liu, B.
    Liu, Y.
    López Grande, I. H.
    Lunghi, T.
    Ma, X.
    Magaña-Loaiza, O. S.
    Magnard, P.
    Magnoni, A.
    Martí­-Prieto, M.
    Martínez, D.
    Mataloni, P.
    Mattar, A.
    Mazzera, M.
    Mirin, R. P.
    Mitchell, M. W.
    Nam, S.
    Oppliger, M.
    Pan, J. -W.
    Patel, R. B.
    Pryde, G. J.
    Rauch, D.
    Redeker, K.
    Rieländer, D.
    Ringbauer, M.
    Roberson, T.
    Rosenfeld, W.
    Salathé, Y.
    Santodonato, L.
    Sauder, G.
    Scheidl, T.
    Schmiegelow, C. T.
    Sciarrino, F.
    Seri, A.
    Shalm, L. K.
    Shi, S. -C
    Slussarenko, S.
    Stevens, M. J.
    Tanzilli, S.
    Toledo, F.
    Tura, J.
    Ursin, R.
    Vergyris, P.
    Verma, V. B.
    Walter, T.
    Wallraff, A.
    Wang, Z.
    Weinfurter, H.
    Weston, M. M.
    White, A. G.
    Wu, C.
    Xavier, Guilherme B.
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska fakulteten.
    You, L.
    Yuan, X.
    Zeilinger, A.
    Zhang, Q.
    Zhang, W.
    Zhong, J.
    Challenging Local Realism with Human Choices2018Inngår i: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 557, s. 212-216Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A Bell test is a randomized trial that compares experimental observations against the philosophical worldview of local realism , in which the properties of the physical world are independent of our observation of them and no signal travels faster than light. A Bell test requires spatially distributed entanglement, fast and high-efficiency detection and unpredictable measurement settings. Although technology can satisfy the first two of these requirements, the use of physical devices to choose settings in a Bell test involves making assumptions about the physics that one aims to test. Bell himself noted this weakness in using physical setting choices and argued that human 'free will' could be used rigorously to ensure unpredictability in Bell tests. Here we report a set of local-realism tests using human choices, which avoids assumptions about predictability in physics. We recruited about 100,000 human participants to play an online video game that incentivizes fast, sustained input of unpredictable selections and illustrates Bell-test methodology. The participants generated 97,347,490 binary choices, which were directed via a scalable web platform to 12 laboratories on five continents, where 13 experiments tested local realism using photons, single atoms, atomic ensembles and superconducting devices. Over a 12-hour period on 30 November 2016, participants worldwide provided a sustained data flow of over 1,000 bits per second to the experiments, which used different human-generated data to choose each measurement setting. The observed correlations strongly contradict local realism and other realistic positions in bi-partite and tri-partite 12 scenarios. Project outcomes include closing the 'freedom-of-choice loophole' (the possibility that the setting choices are influenced by 'hidden variables' to correlate with the particle properties), the utilization of video-game methods for rapid collection of human-generated randomness, and the use of networking techniques for global participation in experimental science.

    Fulltekst (pdf)
    Challenging local realism with human choices
  • 31.
    Abouzeedan, Adli
    et al.
    Innovation and Entrepreneurship, Department of Medicine Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden.
    Hedner, Thomas
    Innovation and Entrepreneurship, Department of Medicine Sahlgrenska Academy, University of.
    Klofsten, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Projekt, innovationer och entreprenörskap. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, HELIX Competence Centre.
    Innovation and entrepreneurship – new themes for new times2010Inngår i: Annals of Innovation & Entrepreneurship, ISSN 2000-7396, E-ISSN 2000-7396, ISSN ISSN 2000-7396, Vol. 1, nr 1, s. 1-3Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    Throughout history, innovators and entrepreneurs have had a tremendous impact on development, exploration, trade, education, science, and integration. During the 20th century, innovation and entrepre-neurship have been regarded as key drivers in technological progress and productivity development worldwide. New radical innovations from new fields of knowledge such as information and communication technologies and biotechnology have emerged to influence everyday life for most people. Realizing this, policy makers as well as individuals argue that innovative and entrepreneurial change processes need to be further implemented on the micro as well as macro levels in society (Abouzeedan, Busler, & Hedner, 2009; Busenitz, Gomez, & Spencer, 2000). The study of innovation is therefore likely to be an increasingly important topic in, for example, economics, business, entrepreneurship, tech-nology, engineering, medicine, environmental biology, sociology, design, and reregional development (cf. Etzkowitz & Klofsten, 2005).

    Fulltekst (pdf)
    fulltext
  • 32.
    Abrahamsson, Annelie
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Onkologiska kliniken US.
    Rzepecka, Anna
    Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping.
    Romu, Thobias
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Borga, Magnus
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Dahlqvist Leinhard, Olof
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Lundberg, Peter
    Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Kihlberg, Johan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping.
    Dabrosin, Charlotta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Onkologiska kliniken US.
    Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo2016Inngår i: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 5, nr 10, artikkel-id e1229723Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment.Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes. On the MRI, lean tissue fraction (LTF) was calculated for a continuous measurement of breast density. LTF confirmed the selection from the mammograms and gave a continuous measurement of breast density. Microdialysis revealed significantly increased extracellular in vivo levels of IL-6, IL-8, vascular endothelial growth factor, and CCL5 in dense breast tissue as compared with nondense breasts. Moreover, the ratio IL-1Ra/IL-1 was decreased in dense breasts. No differences were found in levels of IL-1, IL-1Ra, CCL2, leptin, adiponectin, or leptin:adiponectin ratio between the two breast tissue types. Significant positive correlations between LTF and the pro-inflammatory cytokines as well as between the cytokines were detected. Stainings of the core biopsies exhibited increased levels of immune cells in dense breast tissue.Our data show that dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment and, if confirmed in a larger cohort, suggests novel targets for prevention therapies for women with dense breast tissue.

  • 33.
    Abrahamsson, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Logistik- och kvalitetsutveckling. Linköpings universitet, Tekniska fakulteten.
    Affärsmodeller för citylogistik & samordnad varudistribution: Handbok för kommuner och privata aktörer2017Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Den här handboken är resultatet av forskningsprojektet ”Affärsmodeller för citylogistik” som har finansierats av Vinnova och genomförts av forskare på Linköpings Universitet vid avdelningen Logistik- & Kvalitetsutveckling under perioden 2015 – 2017. Projektet är en direkt uppföljning av Färdplan Citylogistik – Godstransporter i urbana miljöer som visade att citylogistik och samordnad varudistribution behövs för att kunna driva utvecklingen mot mer hållbara och attraktiva städer med emissionsfria godstransporter. Den här boken presenterar en modell som syftar till att hjälpa kommuner och företag att komma igång med citylogistik och samordnad varudistribution – En affärsmodell som också fungerar som ett beslutsunderlag. Projektet grundar sig också i Forsknings- och innovationsagenda för framtidens logistik, där citylogistik lyfts fram som ett av de viktigaste utvecklingsområdena inom logistikområdet i framtiden.

    Fulltekst (pdf)
    Affärsmodeller för citylogistik & samordnad varudistribution : Handbok för kommuner och privata aktörer
  • 34.
    Abrahamsson, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Logistik- och kvalitetsutveckling. Linköpings universitet, Tekniska fakulteten.
    Logistik för ökad svensk konkurrenskraft: Forsknings- och innovationsagenda för framtidens logistik2013Rapport (Annet vitenskapelig)
    Abstract [sv]

    Framtidens logistik står inför mycket stora utmaningar som har direkt bäring på svenska företags och organisationers förmåga till tillväxt, hållbarhet och konkurrenskraft. 

    Det står utom all tvivel att logistikens betydelse kommer att öka ännu mer i framtiden. Vinnare på de globala, rörliga marknaderna kommer ett vara de flödeseffektiva företagen, som har förmåga att hantera förändringarna på marknaden med en effektiv logistik som grund. För att lyckas behövs ett Logistiklyft för Sverige, med ett medvetet fokus på att utveckla de dynamiska förmågorna i företag och organisationer. Detta gäller i de allra flesta branscher och typ av företag.

    Den här innovations- och forskningsagendan utgår från den svenska traditionen och internationellt sett unika kunskapen och förmågan att med en systemsyn som grund designa, utveckla och styra komplexa system där flera olika kompetenser samverkar. Logistikens systemkunskap handlar om att lära sig att utforma och styra omfattande och allt mer komplexa försörjningskedjor (supply chains) från råvara till slutkund i syfte att öka svenska företags internationella konkurrenskraft och förmåga att växa på ett miljömässigt och ekonomiskt hållbart sätt

    Agendan adresserar behovet av kompetens och kunskap för mer innovativ logistikutveckling som följer:

    • Utveckling av kunskap om nya och mer innovativa logistiksystem och modeller för industri & handel 
    • Tjänsteutveckling för transport/logistik och IT-företag som stöd för mer innovativa logistiksystem, men också att ta till vara och stimulera den omfattande tjänsteutveckling som finns i förnyelsen av svenskt näringsliv, t ex mot högre grad av e-handel. 
    • Tillämpning av befintliga logistikkunskaper för områden och sektorer i behov av ett logistiklyft och ökad flödeseffektivitet, t.ex. logistik för små- och medelstora företag (SME) med fokus på HUR (genomförandeprocesser) istället för VAD (utformning av koncept och modeller). 
    • Utveckling av kunskaper om hur logistiksystem kan bidra till en hållbar utveckling, såväl miljömässigt som socialt.
    • Utveckling av kunskap om och tillämpning av logistiklösningar med primär samhällsnytta, t ex sjukvårdslogistik och citylogistik samt effektiv och hållbar försörjning av livsmedel, energi etc.

    Den här forsknigs- och innovationsagendan är utvecklad i samarbete mellan Linköpings Universitet, Lunds Tekniska Högskola, Chalmers Tekniska Högskola och en lång rad företag där Axis, SKF, Volvo och Nobel Biocare har funnits med i projektets styrgrupp. 

    Agendan finns endast som PDF. Kontakta Mats Abrahamsson, Linköpings Universitet. mats.abrahamsson@liu.se

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    Logistik för ökad svensk konkurrenskraft
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  • 35.
    Abrahamsson, Mats
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Logistik- och kvalitetsutveckling. Linköpings universitet, Tekniska fakulteten.
    Christopher, Martin
    Cranfield School of Management, Cranfield, Bedford, UK.
    Stensson, Bo-Inge
    SKF, Sverige.
    Mastering Supply Chain Management in an era of uncertainty at SKF2015Inngår i: Global Business and Organizational Excellence: a review of research & best practices, ISSN 1932-2054, Vol. 34, nr 6, s. 6-17Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    To stay ahead in an increasingly competitive business environment, organizations need agile supply chain systems that are holistically designed and managed. The experiences of SKF, a Swedish multinational firm, point to the benefits of reengineering upstream capabilities to create value downstream. To foster the flexibility, responsiveness, and other dynamic capabilities needed to manage increased supply chain complexity, the company established programs to involve its suppliers in the value creation process, making them an extension of the organization’s resource base. The overall objective has been to migrate from a business model based on economies of scale in operations to one that exploits both economies of scope and economies of integration. As a result of its efforts to create a more agile and cost-efficient supply chain, the company has been able to decrease supply risks while improving its value creation process and responsiveness to new customer demands and advancing its sustainability and social responsibility initiatives. 

  • 36.
    Abrahamsson, Olle
    Linköpings universitet, Matematiska institutionen, Matematik och tillämpad matematik. Linköpings universitet, Tekniska fakulteten.
    A Gröbner basis algorithm for fast encoding of Reed-Müller codes2016Independent thesis Basic level (degree of Bachelor), 10,5 poäng / 16 hpOppgave
    Abstract [en]

    In this thesis the relationship between Gröbner bases and algebraic coding theory is investigated, and especially applications towards linear codes, with Reed-Müller codes as an illustrative example. We prove that each linear code can be described as a binomial ideal of a polynomial ring, and that a systematic encoding algorithm for such codes is given by the remainder of the information word computed with respect to the reduced Gröbner basis. Finally we show how to apply the representation of a code by its corresponding polynomial ring ideal to construct a class of codes containing the so called primitive Reed-Müller codes, with a few examples of this result.

    Fulltekst (pdf)
    fulltext
  • 37.
    Abrahamsson, Tobias
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Poxson, David
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Gabrielsson, Erik
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Sandberg, Mats
    RISE Acreo AB, Sweden.
    Simon, Daniel T
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Formation of Monolithic Ion-Selective Transport Media Based on "Click" Cross-Linked Hyperbranched Polyglycerol2019Inngår i: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 7, artikkel-id 484Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the emerging field of organic bioelectronics, conducting polymers and ion-selective membranes are combined to form resistors, diodes, transistors, and circuits that transport and process both electronic and ionic signals. Such bioelectronics concepts have been explored in delivery devices that translate electronic addressing signals into the transport and dispensing of small charged biomolecules at high specificity and spatiotemporal resolution. Manufacturing such "iontronic" devices generally involves classical thin film processing of polyelectrolyte layers and insulators followed by application of electrolytes. This approach makes miniaturization and integration difficult, simply because the ion selective polyelectrolytes swell after completing the manufacturing. To advance such bioelectronics/iontronics and to enable applications where relatively larger molecules can be delivered, it is important to develop a versatile material system in which the charge/size selectivity can be easily tailormade at the same time enabling easy manufacturing of complex and miniaturized structures. Here, we report a one-pot synthesis approach with minimal amount of organic solvent to achieve cationic hyperbranched polyglycerol films for iontronics applications. The hyperbranched structure allows for tunable pre multi-functionalization, which combines available unsaturated groups used in crosslinking along with ionic groups for electrolytic properties, to achieve a one-step process when applied in devices for monolithic membrane gel formation with selective electrophoretic transport of molecules.

    Fulltekst (pdf)
    fulltext
  • 38.
    Abramavicius, V.
    et al.
    Vilnius University, Lithuania; Centre Phys Science and Technology, Lithuania.
    Pranculis, V.
    Centre Phys Science and Technology, Lithuania.
    Melianas, Armantas
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska fakulteten.
    Inganäs, Olle
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska fakulteten.
    Gulbinas, V.
    Centre Phys Science and Technology, Lithuania.
    Abramavicius, D.
    Vilnius University, Lithuania.
    Role of coherence and delocalization in photo-induced electron transfer at organic interfaces2016Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, nr 32914Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Photo-induced charge transfer at molecular heterojunctions has gained particular interest due to the development of organic solar cells (OSC) based on blends of electron donating and accepting materials. While charge transfer between donor and acceptor molecules can be described by Marcus theory, additional carrier delocalization and coherent propagation might play the dominant role. Here, we describe ultrafast charge separation at the interface of a conjugated polymer and an aggregate of the fullerene derivative PCBM using the stochastic Schrodinger equation (SSE) and reveal the complex time evolution of electron transfer, mediated by electronic coherence and delocalization. By fitting the model to ultrafast charge separation experiments, we estimate the extent of electron delocalization and establish the transition from coherent electron propagation to incoherent hopping. Our results indicate that even a relatively weak coupling between PCBM molecules is sufficient to facilitate electron delocalization and efficient charge separation at organic interfaces.

    Fulltekst (pdf)
    fulltext
  • 39.
    Abramian, David
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Eklund, Anders
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Institutionen för datavetenskap, Statistik och maskininlärning. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    REFACING: RECONSTRUCTING ANONYMIZED FACIAL FEATURES USING GANS2019Inngår i: 2019 IEEE 16TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2019), IEEE , 2019, s. 1104-1108Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Anonymization of medical images is necessary for protecting the identity of the test subjects, and is therefore an essential step in data sharing. However, recent developments in deep learning may raise the bar on the amount of distortion that needs to be applied to guarantee anonymity. To test such possibilities, we have applied the novel CycleGAN unsupervised image-to-image translation framework on sagittal slices of T1 MR images, in order to reconstruct, facial features from anonymized data. We applied the CycleGAN framework on both face-blurred and face-removed images. Our results show that face blurring may not provide adequate protection against malicious attempts at identifying the subjects, while face removal provides more robust anonymization, but is still partially reversible.

    Fulltekst (pdf)
    fulltext
  • 40.
    Abramian, David
    et al.
    Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik.
    Larsson, Martin
    Centre for Mathematical Sciences, Lund University.
    Eklund, Anders
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Behjat, Hamid
    Department of Biomedical Engineering, Lund University.
    Improved Functional MRI Activation Mapping in White Matter Through Diffusion-Adapted Spatial Filtering2020Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Brain activation mapping using functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) contrast has been conventionally focused on probing gray matter, the BOLD contrast in white matter having been generally disregarded. Recent results have provided evidence of the functional significance of the white matter BOLD signal, showing at the same time that its correlation structure is highly anisotropic, and related to the diffusion tensor in shape and orientation. This evidence suggests that conventional isotropic Gaussian filters are inadequate for denoising white matter fMRI data, since they are incapable of adapting to the complex anisotropic domain of white matter axonal connections. In this paper we explore a graph-based description of the white matter developed from diffusion MRI data, which is capable of encoding the anisotropy of the domain. Based on this representation we design localized spatial filters that adapt to white matter structure by leveraging graph signal processing principles. The performance of the proposed filtering technique is evaluated on semi-synthetic data, where it shows potential for greater sensitivity and specificity in white matter activation mapping, compared to isotropic filtering.

  • 41.
    Abramian, David
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik.
    Sidén, Per
    Linköpings universitet, Institutionen för datavetenskap, Statistik och maskininlärning. Linköpings universitet, Filosofiska fakulteten.
    Knutsson, Hans
    Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Villani, Mattias
    Linköpings universitet, Institutionen för datavetenskap, Statistik och maskininlärning. Linköpings universitet, Filosofiska fakulteten. Department of Statistics, Stockholm University.
    Eklund, Anders
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för datavetenskap, Statistik och maskininlärning. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik.
    Anatomically Informed Bayesian Spatial Priors for FMRI Analysis2020Inngår i: / [ed] IEEE, 2020Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Existing Bayesian spatial priors for functional magnetic resonance imaging (fMRI) data correspond to stationary isotropic smoothing filters that may oversmooth at anatomical boundaries. We propose two anatomically informed Bayesian spatial models for fMRI data with local smoothing in each voxel based on a tensor field estimated from a T1-weighted anatomical image. We show that our anatomically informed Bayesian spatial models results in posterior probability maps that follow the anatomical structure.

  • 42.
    Abrikosov, Igor A.
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teoretisk Fysik. Linköpings universitet, Tekniska fakulteten.
    Alling, Björn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Steneteg, Peter
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Hultberg, Lasse
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten.
    Hellman, Olle
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teoretisk Fysik. Linköpings universitet, Tekniska fakulteten.
    Yu Mosyagin, Igor
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teoretisk Fysik. Linköpings universitet, Tekniska fakulteten. Department of Theoretical Physics and Quantum Technologies, National Research, Technological University MISiS, Moscow, Russia.
    Lugovskoy, Andrey V.
    Department of Theoretical Physics and Quantum Technologies, National Research, Technological University MISiS, Russia.
    Barannikova, Svetlana A.
    Institute of Strength Physics and Materials Science, Siberian Branch of Russian Academy of Science, Tomsk, Russia; Department of Physics and Engineering, Tomsk State University, Tomsk, Russia.
    Finite Temperature, Magnetic, and Many-Body Effects in Ab Initio Simulations of Alloy Thermodynamics2013Inngår i: TMS2013 Supplemental Proceedings, John Wiley & Sons, 2013, s. 617-626Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Ab initio electronic structure theory is known as a useful tool for prediction of materials properties. However, majority of simulations still deal with calculations in the framework of density functional theory with local or semi-local functionals carried out at zero temperature. We present new methodological solution.s, which go beyond this approach and explicitly take finite temperature, magnetic, and many-body effects into account. Considering Ti-based alloys, we discuss !imitations of the quasiharmonic approximation for the treatment of lattice vibrations, and present an accurate and easily extendable method to calculate free ,energies of strongly anharmonic solids. We underline the necessity to going beyond the state-of-the-art techniques for the determination of effective cluster interactions in systems exhibiting mctal-to-insulator transition, and describe a unified cluster expansion approach developed for this class of materials. Finally, we outline a first-principles method, disordered local moments molecular dynamics, for calculations of thermodynamic properties of magnetic alloys, like Cr1-x,.AlxN, in their high-temperature paramagnetic state. Our results unambiguously demonstrate importance of finite temperature effects in theoretical calculations ofthermodynamic properties ofmaterials.

  • 43.
    Abrikosov, Igor
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teoretisk Fysik. Linköpings universitet, Tekniska fakulteten. National University of Science and Technology MISIS, Russia.
    Ponomareva, A. V.
    National University of Science and Technology MISIS, Russia.
    Steneteg, Peter
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Barannikova, S. A.
    National University of Science and Technology MISIS, Russia; National Research Tomsk State University, Russia; SB RAS, Russia.
    Alling, Björn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Recent progress in simulations of the paramagnetic state of magnetic materials2016Inngår i: Current opinion in solid state & materials science, ISSN 1359-0286, E-ISSN 1879-0348, Vol. 20, nr 2, s. 85-106Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    We review recent developments in the field of first-principles simulations of magnetic materials above the magnetic order disorder transition temperature, focusing mainly on 3d-transition metals, their alloys and compounds. We review theoretical tools, which allow for a description of a system with local moments, which survive, but become disordered in the paramagnetic state, focusing on their advantages and limitations. We discuss applications of these theories for calculations of thermodynamic and mechanical properties of paramagnetic materials. The presented examples include, among others, simulations of phase stability of Fe, Fe-Cr and Fe-Mn alloys, formation energies of vacancies, substitutional and interstitial impurities, as well as their interactions in Fe, calculations of equations of state and elastic moduli for 3d-transition metal alloys and compounds, like CrN and steels. The examples underline the need for a proper treatment of magnetic disorder in these systems. (C) 2015 Elsevier Ltd. All rights reserved.

    Fulltekst (pdf)
    fulltext
  • 44.
    Abrikossova, Natalia
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Investigation of nanoparticle-cell interactions for development of next generation of biocompatible MRI contrast agents2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Progress in synthesis technologies and advances in fundamental understanding of materials with low dimensionality has led to the birth of a new scientific field, nanoscience, and to strong expectations of multiple applications of nanomaterials. The physical properties of small particles are unique, bridging the gap between atoms and molecules, on one side, and bulk materials on the other side. The work presented in this thesis investigates the potential of using magnetic nanoparticles as the next generation of contrast agents for biomedical imaging. The focus is on gadolinium-based nanoparticles and cellular activity including the uptake, morphology and production of reactive oxygen species.

    Gd ion complexes, like Gd chelates, are used today in the clinic, world-wide. However, there is a need for novel agents, with improved contrast capabilities and increased biocompatibility. One avenue in their design is based on crystalline nanoparticles. It allows to reduce the total number of Gd ions needed for an examination. This can be done by nanotechnology, which allows one to improve and fine tune the physico- chemical properties on the nanomaterial in use, and to increase the number of Gd atoms at a specific site that interact with protons and thereby locally increase the signal. In the present work, synthesis, purification and surface modification of crystalline Gd2O3-based nanoparticles have been performed. The nanoparticles are selected on the basis of their physical properties, that is they show enhanced magnetic properties and therefore may be of high potential interest for applications as contrast agents.

    The main synthesis method of Gd2O3 nanoparticles in this work was the modified “polyol” route, followed by purification of as-synthesized DEG-Gd2O3 nanoparticles suspensions. In most cases the purification step involved dialysis of the nanoparticle samples. In this thesis, organosilane were chosen as an exchange agent for further functionalization. Moreover, several paths have been explored for modification of the nanoparticles, including Tb3+ doping and capping with sorbitol.

    Biocompatibility of the newly designed nanoparticles is a prerequisite for their use in medical applications. Its evaluation is a complex process involving a wide range of biological phenomena. A promising path adopted in this work is to study of nanoparticle interactions with isolated blood cells. In this way one could screen nanomaterial prior to animal studies.

    The primary cell type considered in the thesis are polymorphonuclear neutrophils (PMN) which represent a type of the cells of human blood belonging to the granulocyte family of leukocytes. PMNs act as the first defense of the immune system against invading pathogens, which makes them valuable for studies of biocompatibility of newly synthesized nanoparticles. In addition, an immortalized murine alveolar macrophage cell line (MH-S), THP-1 cell line, and Ba/F3 murine bone marrow-derived cell line were considered to investigate the optimization of the cell uptake and to examine the potential of new intracellular contrast agent for magnetic resonance imaging.

    In paper I, the nanoparticles were investigated in a cellular system, as potential probes for visualization and targeting intended for bioimaging applications. The production of reactive oxygen species (ROS) by means of luminol-dependent chemiluminescence from human neutrophils was studied in presence of Gd2O3 nanoparticles. In paper II, a new design of functionalized ultra-small rare earth-based nanoparticles was reported. The synthesis was done using polyol method followed by PEGylation, and dialysis. Supersmall gadolinium oxide (DEG-Gd2O3) nanoparticles, in the range of 3-5 nm were obtained and carefully characterized. Neutrophil activation after exposure to this nanomaterial was studied by means of fluorescence microscopy. In paper III, cell labeling with Gd2O3 nanoparticles in hematopoietic cells was monitored by magnetic resonance imaging (MRI). In paper IV, ultra-small gadolinium oxide nanoparticles doped with terbium ions were synthesized as a potentially bifunctional material with both fluorescent and magnetic contrast agent properties. Paramagnetic behavior was studied. MRI contrast enhancement was received, and the luminescent/ fluorescent property of the particles was attributable to the Tb3+ ion located on the crystal lattice of the Gd2O3 host. Fluorescent labeling of living cells was obtained. In manuscript V, neutrophil granulocytes were investigated with rapid cell signaling communicative processes in time frame of minutes, and their response to cerium-oxide based nanoparticles were monitored using capacitive sensors based on Lab-on-a-chip technology. This showed the potential of label free method used to measure oxidative stress of neutrophil granulocytes. In manuscript VI, investigations of cell-(DEGGd2O3) nanoparticle interactions were carried out. Plain (DEG-Gd2O3) nanoparticles, (DEG-Gd2O3) nanoparticles in presence of sorbitol and (DEG-Gd2O3) nanoparticles capped with sorbitol were studied. Relaxation studies and measurements of the reactive oxygen species production by neutrophils were based on chemiluminescence. Cell morphology was evaluated as a parameter of the nanoparticle induced inflammatory response by means of the fluorescence microscopy.

    The thesis demonstrates high potential of novel Gd2O3-based nanoparticles for development of the next generation contrast agents, that is to find biocompatible compounds with high relaxivity that can be detected at lower doses, and in the future enable targeting to provide great local contrast.

    Delarbeid
    1. Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes
    Åpne denne publikasjonen i ny fane eller vindu >>Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes
    Vise andre…
    2012 (engelsk)Inngår i: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 23, nr 27, s. 275101-Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    We have previously shown that gadolinium oxide (Gd2O3) nanoparticles are promising candidates to be used as contrast agents in magnetic resonance (MR) imaging applications. In this study, these nanoparticles were investigated in a cellular system, as possible probes for visualization and targeting intended for bioimaging applications. We evaluated the impact of the presence of Gd2O3 nanoparticles on the production of reactive oxygen species (ROS) from human neutrophils, by means of luminol-dependent chemiluminescence. Three sets of Gd2O3 nanoparticles were studied, i.e. as synthesized, dialyzed and both PEG-functionalized and dialyzed Gd2O3 nanoparticles. In addition, neutrophil morphology was evaluated by fluorescent staining of the actin cytoskeleton and fluorescence microscopy. We show that surface modification of these nanoparticles with polyethylene glycol (PEG) is essential in order to increase their biocompatibility. We observed that the as synthesized nanoparticles markedly decreased the ROS production from neutrophils challenged with prey (opsonized yeast particles) compared to controls without nanoparticles. After functionalization and dialysis, more moderate inhibitory effects were observed at a corresponding concentration of gadolinium. At lower gadolinium concentration the response was similar to that of the control cells. We suggest that the diethylene glycol (DEG) present in the as synthesized nanoparticle preparation is responsible for the inhibitory effects on the neutrophil oxidative burst. Indeed, in the present study we also show that even a low concentration of DEG, 0.3%, severely inhibits neutrophil function. In summary, the low cellular response upon PEG-functionalized Gd2O3 nanoparticle exposure indicates that these nanoparticles are promising candidates for MR-imaging purposes.

    sted, utgiver, år, opplag, sider
    Institute of Physics, 2012
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-79667 (URN)10.1088/0957-4484/23/27/275101 (DOI)000305802000001 ()
    Tilgjengelig fra: 2012-08-14 Laget: 2012-08-13 Sist oppdatert: 2018-11-12
    2. Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement
    Åpne denne publikasjonen i ny fane eller vindu >>Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement
    Vise andre…
    2010 (engelsk)Inngår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 26, nr 8, s. 5753-5762Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Recently, much attention has been given to the development of biofunctionalized nanoparticles with magnetic properties for novel biomedical imaging. Guided, smart, targeting nanoparticulate magnetic resonance imaging (MRI) contrast agents inducing high MRI signal will be valuable tools for future tissue specific imaging and investigation of molecular and cellular events. In this study, we report a new design of functionalized ultrasmall rare earth based nanoparticles to be used as a positive contrast agent in MRI. The relaxivity is compared to commercially available Gd based chelates. The synthesis, PEGylation, and dialysis of small (3−5 nm) gadolinium oxide (DEG-Gd2O3) nanoparticles are presented. The chemical and physical properties of the nanomaterial were investigated with Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and dynamic light scattering. Neutrophil activation after exposure to this nanomaterial was studied by means of fluorescence microscopy. The proton relaxation times as a function of dialysis time and functionalization were measured at 1.5 T. A capping procedure introducing stabilizing properties was designed and verified, and the dialysis effects were evaluated. A higher proton relaxivity was obtained for as-synthesized diethylene glycol (DEG)-Gd2O3 nanoparticles compared to commercial Gd-DTPA. A slight decrease of the relaxivity for as-synthesized DEG-Gd2O3 nanoparticles as a function of dialysis time was observed. The results for functionalized nanoparticles showed a considerable relaxivity increase for particles dialyzed extensively with r1 and r2 values approximately 4 times the corresponding values for Gd-DTPA. The microscopy study showed that PEGylated nanoparticles do not activate neutrophils in contrast to uncapped Gd2O3. Finally, the nanoparticles are equipped with Rhodamine to show that our PEGylated nanoparticles are available for further coupling chemistry, and thus prepared for targeting purposes. The long term goal is to design a powerful, directed contrast agent for MRI examinations with specific targeting possibilities and with properties inducing local contrast, that is, an extremely high MR signal at the cellular and molecular level.

    sted, utgiver, år, opplag, sider
    American Chemical Society (ACS), 2010
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-54946 (URN)10.1021/la903566y (DOI)000276562300061 ()
    Tilgjengelig fra: 2010-04-23 Laget: 2010-04-23 Sist oppdatert: 2018-10-29bibliografisk kontrollert
    3. Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement
    Åpne denne publikasjonen i ny fane eller vindu >>Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement
    Vise andre…
    2011 (engelsk)Inngår i: International journal of nano medicine, ISSN 1178-2013, Vol. 6, s. 3233-3240Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    As the utility of magnetic resonance imaging (MRI) broadens, the importance of having specific and efficient contrast agents increases and in recent time there has been a huge development in the fields of molecular imaging and intracellular markers. Previous studies have shown that gadolinium oxide (Gd2O3) nanoparticles generate higher relaxivity than currently available Gd chelates: In addition, the Gd2O3 nanoparticles have promising properties for MRI cell tracking. The aim of the present work was to study cell labeling with Gd2O3 nanoparticles in hematopoietic cells and to improve techniques for monitoring hematopoietic stem cell migration by MRI. Particle uptake was studied in two cell lines: the hematopoietic progenitor cell line Ba/F3 and the monocytic cell line THP-1. Cells were incubated with Gd2O3 nanoparticles and it was investigated whether the transfection agent protamine sulfate increased the particle uptake. Treated cells were examined by electron microscopy and MRI, and analyzed for particle content by inductively coupled plasma sector field mass spectrometry. Results showed that particles were intracellular, however, sparsely in Ba/F3. The relaxation times were shortened with increasing particle concentration. Relaxivities, r1 and r2 at 1.5 T and 21°C, for Gd2O3 nanoparticles in different cell samples were 3.6–5.3 s-1 mM-1 and 9.6–17.2 s-1 mM-1, respectively. Protamine sulfate treatment increased the uptake in both Ba/F3 cells and THP-1 cells. However, the increased uptake did not increase the relaxation rate for THP-1 as for Ba/F3, probably due to aggregation and/or saturation effects. Viability of treated cells was not significantly decreased and thus, it was concluded that the use of Gd2O3 nanoparticles is suitable for this type of cell labeling by means of detecting and monitoring hematopoietic cells. In conclusion, Gd2O3 nanoparticles are a promising material to achieve positive intracellular MRI contrast; however, further particle development needs to be performed.

    sted, utgiver, år, opplag, sider
    Manchester, UK: Dove Medical Press Ltd, 2011
    Emneord
    gadolinium oxide, magnetic resonance imaging, contrast agent, cell labeling, Ba/F3 cells, THP-1 cells
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-72275 (URN)10.2147/IJN.S23940 (DOI)000298164300001 ()
    Merknad

    funding agencies|Swedish Research Council| 621-2007-3810 621-2009-5148 521-2009-3423 |VINNOVA| 2009-00194 |Center in Nanoscience and Technology at LiTH (CeNano)||

    Tilgjengelig fra: 2011-11-24 Laget: 2011-11-24 Sist oppdatert: 2018-10-29
    4. Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties
    Åpne denne publikasjonen i ny fane eller vindu >>Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties
    Vise andre…
    2009 (engelsk)Inngår i: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 113, nr 17, s. 6913-6920Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Ultrasmall gadolinium oxide nanoparticles doped with terbium ions were synthesized by the polyol route and characterized as a potentially bifunctional material with both fluorescent and magnetic contrast agent properties. The structural, optical, and magnetic properties of the organic-acid-capped and PEGylated Gd2O3:Tb3+ nanocrystals were studied by HR-TEM, XPS, EDX, IR, PL, and SQUID. The luminescent/fluorescent property of the particles is attributable to the Tb3+ ion located on the crystal lattice of the Gd2O3 host. The paramagnetic behavior of the particles is discussed. Pilot studies investigating the capability of the nanoparticles for fluorescent labeling of living cells and as a MRI contrast agent were also performed. Cells of two cell lines (THP-1 cells and fibroblasts) were incubated with the particles, and intracellular particle distribution was visualized by confocal microscopy. The MRI relaxivity of the PEGylated nanoparticles in water at low Gd concentration was assessed showing a higher T-1 relaxation rate compared to conventional Gd-DTPA chelates and comparable to that of undoped Gd2O3 nanoparticles.

    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-12944 (URN)10.1021/jp808708m (DOI)000265529700009 ()
    Merknad

    On the day of the defence date the status of this article was Submitted

    Tilgjengelig fra: 2008-02-21 Laget: 2008-02-21 Sist oppdatert: 2018-10-29bibliografisk kontrollert
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  • 45.
    Abrikossova, Natalia
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Skoglund, Caroline
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska högskolan.
    Ahrén, Maria
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Bengtsson, Torbjorn
    University of Örebro, Sweden .
    Uvdal, Kajsa
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes2012Inngår i: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 23, nr 27, s. 275101-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We have previously shown that gadolinium oxide (Gd2O3) nanoparticles are promising candidates to be used as contrast agents in magnetic resonance (MR) imaging applications. In this study, these nanoparticles were investigated in a cellular system, as possible probes for visualization and targeting intended for bioimaging applications. We evaluated the impact of the presence of Gd2O3 nanoparticles on the production of reactive oxygen species (ROS) from human neutrophils, by means of luminol-dependent chemiluminescence. Three sets of Gd2O3 nanoparticles were studied, i.e. as synthesized, dialyzed and both PEG-functionalized and dialyzed Gd2O3 nanoparticles. In addition, neutrophil morphology was evaluated by fluorescent staining of the actin cytoskeleton and fluorescence microscopy. We show that surface modification of these nanoparticles with polyethylene glycol (PEG) is essential in order to increase their biocompatibility. We observed that the as synthesized nanoparticles markedly decreased the ROS production from neutrophils challenged with prey (opsonized yeast particles) compared to controls without nanoparticles. After functionalization and dialysis, more moderate inhibitory effects were observed at a corresponding concentration of gadolinium. At lower gadolinium concentration the response was similar to that of the control cells. We suggest that the diethylene glycol (DEG) present in the as synthesized nanoparticle preparation is responsible for the inhibitory effects on the neutrophil oxidative burst. Indeed, in the present study we also show that even a low concentration of DEG, 0.3%, severely inhibits neutrophil function. In summary, the low cellular response upon PEG-functionalized Gd2O3 nanoparticle exposure indicates that these nanoparticles are promising candidates for MR-imaging purposes.

  • 46.
    Acevedo, Juan Pablo
    et al.
    Univ Los Andes, Chile; Cells Cells, Chile.
    Angelopoulos, Ioannis
    Univ Los Andes, Chile; Cells Cells, Chile.
    van Noort, Danny
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten. Univ Los Andes, Chile.
    Khoury, Maroun
    Univ Los Andes, Chile; Cells Cells, Chile; Consorcio Regenero, Chile.
    Microtechnology applied to stem cells research and development2018Inngår i: Regenerative Medicine, ISSN 1746-0751, E-ISSN 1746-076X, Vol. 13, nr 2, s. 233-248Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Microfabrication and microfluidics contribute to the research of cellular functions of cells and their interaction with their environment. Previously, it has been shown that microfluidics can contribute to the isolation, selection, characterization and migration of cells. This review aims to provide stem cell researchers with a toolkit of microtechnology (mT) instruments for elucidating complex stem cells functions which are challenging to decipher with traditional assays and animal models. These microdevices are able to investigate about the differentiation and niche interaction, stem cells transcriptomics, therapeutic functions and the capture of their secreted microvesicles. In conclusion, microtechnology will allow a more realistic assessment of stem cells properties, driving and accelerating the translation of regenerative medicine approaches to the clinic.

  • 47.
    Achichi, Manel
    et al.
    Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier (LIRMM), France; University of Montpellier, France.
    Cheatham, Michelle
    Wright State University, USA.
    Dragisic, Zlatan
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Euzenat, Jerome
    INRIA, France; University Grenoble Alpes, Grenoble, France.
    Faria, Daniel
    Instituto Gulbenkian de Ciencia, Lisbon, Portugal.
    Ferrara, Alfio
    Universita degli studi di Milano, Italy.
    Flouris, Giorgos
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Fundulaki, Irini
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Harrow, Ian
    Pistoia Alliance Inc., USA.
    Ivanova, Valentina
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Jimenez-Ruiz, Ernesto
    University of Oslo, Norway.
    Kolthoff, Kristian
    University of Mannheim, Germany.
    Kuss, Elena
    University of Mannheim, Germany.
    Lambrix, Patrick
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Leopold, Henrik
    Vrije Universiteit Amsterdam, Netherlands.
    Li, Huanyu
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Meilicke, Christian
    University of Mannheim, Germany.
    Mohammadi, Majid
    Technical University of Delft, Netherlands.
    Montanelli, Stefano
    Universita degli studi di Milano, Italy.
    Pesquita, Catia
    Universidade de Lisboa, Portugal.
    Saveta, Tzanina
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Shvaiko, Pavel
    Informatica Trentina, Trento, Italy.
    Splendiani, Andrea
    Pistoia Alliance Inc., USA.
    Stuckenschmidt, Heiner
    University of Mannheim, Germany.
    Thieblin, Elodie
    Institut de Recherche en Informatique de Toulouse (IRIT), France; Universite Toulouse II, Toulouse, France.
    Todorov, Konstantin
    Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier (LIRMM), France; University of Montpellier, France.
    Trojahn, Cassia
    Institut de Recherche en Informatique de Toulouse (IRIT); Universite Toulouse II, Toulouse, France.
    Zamazal, Ondrej
    University of Economics, Prague, Czech Republic.
    Results of the Ontology Alignment Evaluation Initiative 20172017Inngår i: Proceedings of the 12th International Workshop on Ontology Matching co-located with the 16th International Semantic Web Conference (ISWC 2017) / [ed] Pavel Shvaiko, Jerome Euzenat, Ernesto Jimenez-Ruiz, Michelle Cheatham, Oktie Hassanzadeh, Aachen, Germany: CEUR Workshop Proceedings , 2017, s. 61-113Konferansepaper (Fagfellevurdert)
  • 48.
    Achichi, Manel
    et al.
    LIRMM, University of Montpellier, France.
    Cheatham, Michelle
    Wright State University, USA.
    Dragisic, Zlatan
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Euzenat, Jerome
    INRIA, France; Univ. Grenoble Alpes, Grenoble, France.
    Faria, Daniel
    Instituto Gulbenkian de Ciencia, Lisbon, Portugal.
    Ferrara, Alfio
    Universita degli studi di Milano, Italy.
    Flouris, Giorgos
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Fundulaki, Irini
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Harrow, Ian
    Pistoia Alliance Inc., USA.
    Ivanova, Valentina
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Jiménez-Ruiz, Ernesto
    University of Oslo, Norway; University of Oxford, UK.
    Kuss, Elena
    University of Mannheim, Germany.
    Lambrix, Patrick
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Leopold, Henrik
    Vrije Universiteit Amsterdam, The Netherlands.
    Li, Huanyu
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Meilicke, Christian
    University of Mannheim, Germany.
    Montanelli, Stefano
    Universita degli studi di Milano, Italy.
    Pesquita, Catia
    Universidade de Lisboa, Portugal.
    Saveta, Tzanina
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Shvaiko, Pavel
    TasLab, Informatica Trentina, Trento, Italy.
    Splendiani, Andrea
    Novartis Institutes for Biomedical Research, Basel, Switzerland.
    Stuckenschmidt, Heiner
    University of Mannheim, Germany.
    Todorov, Konstantin
    LIRMM, University of Montpellier, France.
    Trojahn, Cassia
    IRIT, Toulouse, France; Université Toulouse II, Toulouse, France.
    Zamazal, Ondřej
    University of Economics, Prague, Czech Republic.
    Results of the Ontology Alignment Evaluation Initiative 20162016Inngår i: Proceedings of the 11th International Workshop on Ontology Matching, Aachen, Germany: CEUR Workshop Proceedings , 2016, s. 73-129Konferansepaper (Fagfellevurdert)
  • 49.
    Achten, Peter
    et al.
    INNAS, Netherlands.
    Mommers, Robin
    INNAS, Netherlands.
    Nishiumi, Takao
    Natl Def Acad, Japan.
    Murrenhoff, Hubertus
    Ifas RWTH Aachen Univ, Germany.
    Sepehri, Nariman
    Univ Manitoba, Canada.
    Stetson, Kim
    Univ Minnesota, MN USA.
    Palmberg, Jan-Ove
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Fluida och mekatroniska system. Linköpings universitet, Tekniska fakulteten.
    Schmitz, Katharina
    Ifas RWTH Aachen Univ, Germany.
    MEASURING THE LOSSES OF HYDROSTATIC PUMPS AND MOTORS: A CRITICAL REVIEW OF ISO4409:20072020Inngår i: PROCEEDINGS OF THE ASME/BATH SYMPOSIUM ON FLUID POWER AND MOTION CONTROL, 2019, AMER SOC MECHANICAL ENGINEERS , 2020, artikkel-id UNSP V001T01A007Konferansepaper (Fagfellevurdert)
    Abstract [en]

    ISO 4409 is the most important international standard for measuring the efficiency of hydraulic pumps and motors, the latest edition being 4409:2007. The standard describes methods for determining the steady-state performance in terms of overall efficiency. It also defines equations for calculating the volumetric efficiency of pumps and motors. The hydromechanical efficiency is only defined for motors, not for pumps. This paper analyses the efficiency and losses of pumps and motors in an alternative way. The preference is on loss analysis instead of efficiencies. Especially the effects of the bulk modulus are considered in a different and more inclusive manner. The new methodology results in a higher total loss for motor and a lower total loss for pumps than the current ISO 4409 standard. Furthermore, it results in significant changes of the hydro-mechanical and volumetric losses. The differences between the new methodology and ISO 4409 become larger for high load pressures. The new methodology demands knowledge about the minimum volume of the displacement chamber. The ratio between this volume and the full displacement of a single displacement chamber strongly influences the hydro mechanical and volumetric losses of the pump or motor. The new methodology is valid for all positive displacement hydrostatic pumps and motors. The volumetric efficiency, as defined in ISO 4409, can still be used as a flow rate factor, but should not be regarded as an energy conversion efficiency. The importance of adopting the proposed methodology is further demonstrated by analyzing and comparing the measurement data about a fixed displacement pump and motor, showing the differences in the loss analysis by means of ISO 4409 and the new equations. The methodology, observations and validation results presented in this paper are significant and can pave the road for improving the current ISO 4409:2007 standard, which would ultimately benefit the industry.

  • 50. Bestill onlineKjøp publikasjonen >>
    Adam, Rania Elhadi
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik, elektroteknik och matematik. Linköpings universitet, Tekniska fakulteten.
    Synthesis and Characterization of Some Nanostructured Materials for Visible Light-driven Photo Processes2020Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Nanostructured materials for visible light driven photo-processes such as photodegradation of organic pollutants and photoelectrochemical (PEC) water oxidation for hydrogen production are very attractive because of the positive impact on the environment. Metal oxides-based nanostructures are widely used in these photoprocesses due to their unique properties. But single nanostructured metal oxide material might suffer from low efficiency and instability in aqueous solutions under visible light. These facts make it important to have an efficient and reliable nanocomposite for the photo-processes. The combination of different nanomaterials to form a composite configuration can produce a material with new properties. The new properties which are due to the synergetic effect, are a combination of the properties of all the counterparts of the nanocomposite. Zinc oxides (ZnO) have unique optical and electrical properties which grant it to be used in optoelectronics, sensors, solar cells, nanogenerators, and photocatalysis activities. Although ZnO absorbs visible light from the sun due to the deep level band, it mainly absorbs ultraviolet wavelengths which constitute a small portion of the whole solar spectrum range. Also, ZnO has a problem with the high recombination rate of the photogenerated electrons. These problems might reduce its applicability to the photo-process. Therefore, our aim is to develop and investigate different nanocomposites materials based on the ZnO nanostructures for the enhancement of photocatalysis processes using the visible solar light as a green source of energy. Two photo-processes were applied to examine the developed nanocomposites through photocatalysis: (1) the photodegradation of organic dyes, (2) PEC water splitting. In the first photo-process, we used the ZnO nanoparticles (NPs), Magnesium (Mg)-doped ZnO NPs, and plasmonic ZnO/graphene-based nanocomposite for the decomposition of some organic dyes that have been used in industries. For the second photo-process, ZnO photoelectrode composite with different silver-based semiconductors to enhance the performance of the ZnO photoelectrode was used for PEC reaction analysis to perform water splitting. The characterization and photocatalysis experiment results showed remarkable enhancement in the photocatalysis efficiency of the synthesized nanocomposites. The observed improved properties of the ZnO are due to the synergetic effects are caused by the addition of the other nanomaterials. Hence, the present thesis attends to the synthesis and characterization of some nanostructured materials composite with ZnO that are promising candidates for visible light-driven photo-processes.  

    Delarbeid
    1. Synthesis of ZnO nanoparticles by co-precipitation method for solar driven photodegradation of Congo red dye at different pH
    Åpne denne publikasjonen i ny fane eller vindu >>Synthesis of ZnO nanoparticles by co-precipitation method for solar driven photodegradation of Congo red dye at different pH
    2018 (engelsk)Inngår i: PHOTONICS AND NANOSTRUCTURES-FUNDAMENTALS AND APPLICATIONS, ISSN 1569-4410, Vol. 32, s. 11-18Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Solar driven photocatalytic processes to remove organic pollutants from wastewater and other aqueous solutions is very important and useful due to its environmental benefits regarding sustainability aspect. In this article, we report a study on the use of bare zinc oxide (ZnO) nanoparticles (NPs) prepared by the chemical low temperature co-precipitation method and used as a catalyst to degrade the Congo red dye from aqueous solution using solar radiation. We performed the photocatalytic experiments for degradation of Congo red dye under solar radiation at different pH values. The results showed that the ZnO NPs are effective under solar radiation for degradation of Congo red dye. Even when the pH was varied down to 4 or raised to 10, the degradation was observed to be slightly improved. This result is due to the excess of radicals species, which enhance the photocatalytic process. In general, the observed degradation efficiency of the ZnO NPs is due to the deep level defects within the band gap that were introduced during the growth process of the ZnO NPs, which enhance the absorption wavelength band towards the visible light region. Recycling of the ZnO NPs for 3 successive runs have indicated the feasibility of reusing the NPs for several times. This implies that by using bare ZnO NPs an efficient approach for degradation of toxic waste can be achieved. Radical scavengers were used to evaluate the role of the radicals in the reaction mechanism.

    sted, utgiver, år, opplag, sider
    ELSEVIER SCIENCE BV, 2018
    Emneord
    ZnO nanoparticles; Point defects; Photocatalytic
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-153525 (URN)10.1016/j.photonics.2018.08.005 (DOI)000451653700003 ()
    Merknad

    Funding Agencies|department of Science and Technology, Linkoping University, Sweden

    Tilgjengelig fra: 2018-12-20 Laget: 2018-12-20 Sist oppdatert: 2020-03-18
    2. Synthesis of Mg-doped ZnO NPs via a chemical low-temperature method and investigation of the efficient photocatalytic activity for the degradation of dyes under solar light
    Åpne denne publikasjonen i ny fane eller vindu >>Synthesis of Mg-doped ZnO NPs via a chemical low-temperature method and investigation of the efficient photocatalytic activity for the degradation of dyes under solar light
    Vise andre…
    2020 (engelsk)Inngår i: Solid State Sciences, ISSN 1293-2558, E-ISSN 1873-3085, Vol. 99, artikkel-id 106053Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Doped semiconductors nanostructures (NSs) have shown great interest as a potential for green and efficient photocatalysis activities. Magnesium (Mg)-doped zinc oxide (ZnO) nanoparticles (NPs) has been synthesized by a one-step chemical low temperature (60 °C) co-precipitation method without further calcination and their photocatalytic performance for photodegradation of Methylene blue (MB) dye under the illumination of solar light is investigated. The crystal structure of the synthesized NPs is examined by X-ray diffraction (XRD). XRD data indicates a slight shift towards higher 2θ angle in Mg-doped samples as compared to the pure ZnO NPs which suggest the incorporation of Mg2+ into ZnO crystal lattice. X-ray photoelectron spectroscopy (XPS), UV–Vis spectrophotometer and cathodoluminescence (CL) spectroscopy, were used to study electronics, and optical properties, respectively. The XPS analysis confirms the substitution of the Zn2+ by the Mg2+ into the ZnO crystal lattice in agreement with the XRD data. The photocatalytic activities showed a significant enhancement of the Mg-doped ZnO NPs in comparison with pure ZnO NPs. Hole/radical scavengers were used to reveal the mechanism of the photodegradation. It was found that the addition of the Mg to the ZnO lattices increases the absorption of the hydroxyl ions at the surface of the NPs and hence acts as a trap site leading to decrease the electron-hole pair and consequently enhancing the photodegradation.

    sted, utgiver, år, opplag, sider
    Elsevier, 2020
    Emneord
    ZnO nanoparticles, Mg-doped ZnO NPs, Photocatalytic, Photodegradation, Methylene blue, Congo red
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-164333 (URN)10.1016/j.solidstatesciences.2019.106053 (DOI)000516720100024 ()2-s2.0-85074706430 (Scopus ID)
    Tilgjengelig fra: 2020-03-18 Laget: 2020-03-18 Sist oppdatert: 2020-03-24bibliografisk kontrollert
    3. Graphene-based plasmonic nanocomposites for highly enhanced solar-driven photocatalytic activities
    Åpne denne publikasjonen i ny fane eller vindu >>Graphene-based plasmonic nanocomposites for highly enhanced solar-driven photocatalytic activities
    Vise andre…
    2019 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 9, nr 52, s. 30585-30598Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    High-efficiency photocatalysts are crucial for the removal of organic pollutants and environmental sustainability. In the present work, we report on a new low-temperature hydrothermal chemical method, assisted by ultrasonication, to synthesize disruptive plasmonic ZnO/graphene/Ag/AgI nanocomposites for solar-driven photocatalysis. The plasmonic nanocomposites were investigated by a wide range of characterization techniques, confirming successful formation of photocatalysts with excellent degradation efficiency. Using Congo red as a model dye molecule, our experimental results demonstrated a photocatalytic reactivity exceeding 90% efficiency after one hour simulated solar irradiation. The significantly enhanced degradation efficiency is attributed to improved electronic properties of the nanocomposites by hybridization of the graphene and to the addition of Ag/AgI which generates a strong surface plasmon resonance effect in the metallic silver further improving the photocatalytic activity and stability under solar irradiation. Scavenger experiments suggest that superoxide and hydroxyl radicals are responsible for the photodegradation of Congo red. Our findings are important for the fundamental understanding of the photocatalytic mechanism of ZnO/graphene/Ag/AgI nanocomposites and can lead to further development of novel efficient photocatalyst materials.

    sted, utgiver, år, opplag, sider
    Royal Meteorological Society, 2019
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-160568 (URN)10.1039/C9RA06273D (DOI)000487989300064 ()
    Merknad

    Funding agencies: Department of Science and Technology (ITN) at Campus Norrkoping, Linkoping University, Sweden; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation

    Tilgjengelig fra: 2019-09-30 Laget: 2019-09-30 Sist oppdatert: 2020-03-18bibliografisk kontrollert
    4. n–n ZnO–Ag2CrO4 heterojunction photoelectrodes with enhanced visible-light photoelectrochemical properties
    Åpne denne publikasjonen i ny fane eller vindu >>n–n ZnO–Ag2CrO4 heterojunction photoelectrodes with enhanced visible-light photoelectrochemical properties
    Vise andre…
    2019 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 9, nr 14, s. 7992-8001Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    In this study, ZnO nanorods (NRs) were hydrothermally grown on an Au-coated glass substrate at a relatively low temperature (90 °C), followed by the deposition of Ag2CrO4 particles via a successive ionic layer adsorption and reaction (SILAR) route. The content of the Ag2CrO4 particles on ZnO NRs was controlled by changing the number of SILAR cycles. The fabricated ZnO–Ag2CrO4 heterojunction photoelectrodes were subjected to morphological, structural, compositional, and optical property analyses; their photoelectrochemical (PEC) properties were investigated under simulated solar light illumination. The photocurrent responses confirmed that the ability of the ZnO–Ag2CrO4 heterojunction photoelectrodes to separate the photo-generated electron–hole pairs is stronger than that of bare ZnO NRs. Impressively, the maximum photocurrent density of about 2.51 mA cm−2 at 1.23 V (vs. Ag/AgCl) was measured for the prepared ZnO–Ag2CrO4 photoelectrode with 8 SILAR cycles (denoted as ZnO–Ag2CrO4-8), which exhibited about 3-fold photo-enhancement in the current density as compared to bare ZnO NRs (0.87 mA cm−2) under similar conditions. The improvement in photoactivity was attributed to the ideal band gap and high absorption coefficient of the Ag2CrO4 particles, which resulted in improved solar light absorption properties. Furthermore, an appropriate annealing treatment was proven to be an efficient process to increase the crystallinity of Ag2CrO4 particles deposited on ZnO NRs, which improved the charge transport characteristics of the ZnO–Ag2CrO4-8 photoelectrode annealed at 200 °C and increased the performance of the photoelectrode. The results achieved in the present work present new insights for designing n–n heterojunction photoelectrodes for efficient and cost-effective PEC applications and solar-to-fuel energ

    sted, utgiver, år, opplag, sider
    Royal Society of Chemistry, 2019
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-155657 (URN)10.1039/C9RA00639G (DOI)000462646000051 ()2-s2.0-85062919263 (Scopus ID)
    Merknad

    Funding agencies: University of Mohaghegh Ardabili-Iran and Linkoping University-Sweden; AForsk [17-457

    Tilgjengelig fra: 2019-03-22 Laget: 2019-03-22 Sist oppdatert: 2020-03-18bibliografisk kontrollert
    5. ZnO/Ag/Ag2WO4 photo-electrodes with plasmonic behavior for enhanced photoelectrochemical water oxidation
    Åpne denne publikasjonen i ny fane eller vindu >>ZnO/Ag/Ag2WO4 photo-electrodes with plasmonic behavior for enhanced photoelectrochemical water oxidation
    Vise andre…
    2019 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 9, nr 15, s. 8271-8279Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Ag-based compounds are excellent co-catalyst that can enhance harvesting visible light and increase photo-generated charge carrier separation owing to its surface plasmon resonance (SPR) effect in photoelectrochemical (PEC) applications. However, the PEC performance of a ZnO/Ag/Ag2WO4 heterostructure with SPR behavior has not been fully studied so far. Here we report the preparation of a ZnO/Ag/Ag2WO4 photo-electrode with SPR behavior by a low temperature hydrothermal chemical growth method followed by a successive ionic layer adsorption and reaction (SILAR) method. The properties of the prepared samples were investigated by different characterization techniques, which confirm that Ag/Ag2WO4 was deposited on the ZnO NRs. The Ag2WO4/Ag/ZnO photo-electrode showed an enhancement in PEC performance compared to bare ZnO NRs. The observed enhancement is attributed to the red shift of the optical absorption spectrum of the Ag2WO4/Ag/ZnO to the visible region (>400 nm) and to the SPR effect of surface metallic silver (Ag0) particles from the Ag/Ag2WO4 that could generate electron–hole pairs under illumination of low energy visible sun light. Finally, we proposed the PEC mechanism of the Ag2WO4/Ag/ZnO photo-electrode with an energy band structure and possible electron–hole separation and transportation in the ZnO/Ag/Ag2WO4 heterostructure with SPR effect for water oxidation. ER

    sted, utgiver, år, opplag, sider
    Royal Society of Chemistry, 2019
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-155655 (URN)10.1039/C8RA10141H (DOI)000461445300016 ()
    Tilgjengelig fra: 2019-03-22 Laget: 2019-03-22 Sist oppdatert: 2020-03-18bibliografisk kontrollert
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