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  • 1.
    Ali Malik, Muhammad
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, Faculty of Science & Engineering.
    Gatto, Emanuela
    University Roma Tor Vergata.
    Macken, Stephen
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, Faculty of Science & Engineering.
    DiNatale, Corrado
    University Roma Tor Vergata.
    Paolesse, Roberto
    University Roma Tor Vergata.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Imaging fingerprinting of excitation emission matrices2009In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 635, no 2, p. 196-201Article in journal (Refereed)
    Abstract [en]

    The spectral fingerprinting of the excitation emission matrix (EEM) of fluorescent substances is demonstrated using polychromatic light sources and tri-chromatic image detectors. A model of the measured fingerprints explaining their features and classification performance, based on the polychromatic excitation of the indicators is proposed.

    Substantial amount of spectral information is retained in the fingerprints as corroborated by multivariate analysis and experimental conditions that favor such situation are identified.

    In average, for five different substances, the model shows a fitting goodness measured by the Pearsons r coefficient and the root mean square deviation of 0.8541 and 0.0247 respectively, while principal component classification patterns satisfactorily compare with the EEM spectroscopy classification and respectively explain 96% and 93% of the information in the fist two principal components.

    The measurements can be performed using regular computer screens as illumination and web cameras as detectors, which constitute ubiquitous and affordable platforms compatible with distributed evaluations, in contrast to regular instrumentation for EEM measurements.

  • 2.
    Alimelli, Adriano
    et al.
    Dept of Electronic Engineering University of Rome.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Paolesse, Roberto
    dept of Chemical science and technology University of Rome.
    Moretti, Simonetta
    Instituto sperimentale per l´enologia.
    Ciolfi, Gaetano
    Instituto sperimentale per l´enologia.
    D´Amico, Arnaldo
    Dept. of Electronic Engineering University of Rome.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, Corradeo
    Dept. of Electronic Engineering University of Rome.
    Direct quantitative evaluation of complex substances using computer screen photo-assisted technology: The case of red wine2007In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 597, p. 103-112Article in journal (Refereed)
  • 3. Alimelli, Adriano
    et al.
    Pennazza, Giorgio
    Santonico, Marco
    Paolesse, Roberto
    University of Rome, Italy.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    D´Amico, Arnaldo
    University of Rome, Italy.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, Corrado
    University of Rome, Italy.
    Fish freshness detection by a computer screen photoassisted based gas sensor array2007In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 582, no 2, p. 320-328Article in journal (Refereed)
    Abstract [en]

    In the last years a large number of different measurement methodologies were applied to measure the freshness of fishes. Among them the connection between freshness and headspace composition has been considered by gas chromatographic analysis and from the last two decades by a number of sensors and biosensors aimed at measuring some characteristic indicators (usually amines). More recently also the so-called artificial olfaction systems gathering together many non-specific sensors have shown a certain capability to transduce the global composition of the fish headspace capturing the differences between fresh and spoiled products. One of the main objectives related to the introduction of sensor systems with respect to the analytical methods is the claimed possibility to distribute the freshness control since sensors are expected to be "portable" and "simple". In spite of these objectives, until now sensor systems did not result in any tool that may be broadly distributed. In this paper, we present a chemical sensor array where the optical features of layers of chemicals, sensitive to volatile compounds typical of spoilage processes in fish, are interrogated by a very simple platform based on a computer screen and a web cam. An array of metalloporphyrins is here used to classify fillets of thawed fishes according to their storage days and to monitor the spoilage in filleted anchovies for a time of 8 h. Results indicate a complete identification of the storage days of thawed fillets and a determination of the storage time of anchovies held at room temperature with a root mean square error of validation of about 30 min. The optical system produces a sort of spectral fingerprint containing information about both the absorbance and the emission of the sensitive layer. The system here illustrated, based on computer peripherals, can be easily scaled to any device endowed with a programmable screen and a camera such as cellular phones offering for the first time the possibility to fulfil the sensor expectation of diffused and efficient analytical capabilities. © 2006 Elsevier B.V. All rights reserved.

  • 4.
    Anderson, Tony
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Johansson, Therese
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Svensson, Samuel
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Frog melanophores cultured on fluorescent microbeads: Biomimic-based biosensing2005In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 21, no 1, p. 111-120Article in journal (Refereed)
    Abstract [en]

    Melanophores are pigmented cells in lower vertebrates capable of quick color changes and thereby suitable as whole cell biosensors. In the frog dermis skin layer, the large and dark pigmented melanophore surrounds a core of other pigmented cells. Upon hormonal stimulation the black-brown pigment organelles will redistribute within the melanophore, and thereby cover or uncover the core, making complex color changes possible in the dermis. Previously, melanophores have only been cultured on flat surfaces. Here we mimic the three dimensional biological geometry in the frog dermis by culturing melanophores on fluorescent plastic microbeads. To demonstrate biosensing we use the hormones melatonin and α-melanocyte stimulating hormone (α-MSH) as lightening or darkening stimuli, respectively. Cellular responses were successfully demonstrated on single cell level by fluorescence microscopy, and in cell suspension by a fluorescence microplate reader and a previously demonstrated computer screen photo-assisted technique. The demonstrated principle is the first step towards "single well/multiple read-out" biosensor arrays based on suspensions of different selective-responding melanophores, each cultured on microbeads with distinctive spectral characteristics. By applying small amount of a clinical sample, or a candidate substance in early drug screening, to a single well containing combinations of melanophores on beads, multiple parameter read-outs will be possible. © 2004 Elsevier B.V. All rights reserved.

  • 5.
    Arwin, Hans
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-assisted measurement of intensity or polarization change of light upon interaction with a sample2006Patent (Other (popular science, discussion, etc.))
  • 6.
    Arwin, Hans
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    A computer as imaging ellipsometer: biosensing at home2006In: Europtrode VIII,2006, 2006Conference paper (Other academic)
  • 7.
    Arwin, Hans
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Computer screen photo-assisted ellipsometry2006In: 4th Workshop Ellipsometry,2006, 2006Conference paper (Other academic)
    Abstract [en]

      

  • 8.
    Bakker, Jimmy
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Arwin, Hans
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Biosensor for home use: using the computer as ellipsometer2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Konferensbidrag (muntligt-1:a pris) vid "EUROPT(R)ODE VIII, Tübingen, Germany, 2-5 april

  • 9.
    Bakker, Jimmy
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Fluorescence based sensing in a CSPT setup2005In: Medicinteknikdagarna,2005, 2005Conference paper (Other academic)
  • 10.
    Bakker, Jimmy W. P.
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Enhancing classification capabilities of computer screen photo-assisted fluorescence fingerprinting2005In: Sensors and Actuators B: Chemical, ISSN 0925-4005, Vol. 110, no 2, p. 190-194Article in journal (Refereed)
    Abstract [en]

    The separation of emission from transmitted light for the fingerprinting of fluorescent substances using a computer screen photo-assisted technique (CSPT) is demonstrated. CSPT is a technique for optical evaluation using a simple cell with just a standard computer set and a web camera as instrumentation. It has been demonstrated to be a versatile system for colorimetric and fluorescent fingerprinting. Here the omnidirectional property of fluorescent emission is utilized to separate it from the background, using a simple optical arrangement compatible with CSPT purposes. This enhances the classification capabilities and makes classification at sub-μM concentrations possible.

  • 11.
    Bakker, Jimmy W.P.
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Arwin, Hans
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Computer screen photo-assisted off-null ellipsometry2006In: Applied Optics, ISSN 1559-128X, E-ISSN 2155-3165, Vol. 45, no 30, p. 7795-7799Article in journal (Refereed)
    Abstract [en]

    The ellipsometric measurement of thickness is demonstrated using a computer screen as a light source and a webcam as a detector, adding imaging off-null ellipsometry to the range of available computer screen photoassisted techniques. The results show good qualitative agreement with a simplified theoretical model and a thickness resolution in the nanometer range is achieved. The presented model can be used to optimize the setup for sensitivity. Since the computer screen serves as a homogeneous large area illumination source, which can be tuned to different intensities for different parts of the sample, a large sensitivity range can be obtained without sacrificing thickness resolution.

  • 12.
    Bakker, Jimmy W.P.
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Arwin, Hans
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Immunodetection using computer screen photo-assisted ellipsometry2008In: Physica Status Solidi. C: Current Topics in Solid State Physics, ISSN 1862-6351, Vol. 5, no 5, p. 1431-1433Article in journal (Refereed)
    Abstract [en]

    Detection of antibody-antigen reactions is demonstrated by measuring changes in reflectance of light polarized parallel to the plane of incidence, using a computer screen as light source and a web camera as detector, giving results similar to traditional off-null ellipsometry and in accordance with a simplified theoretical model.

  • 13.
    Bakker, Jimmy W.P.
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Two-dimensional micro array fluorescence fingerprinting with a computer screen photo-assisted technique2005In: Spectral Imaging: Instrumentation, Applications, and Analysis III, 2005, p. 9-15Conference paper (Other academic)
    Abstract [en]

    Detection and classification of fluorescent dyes are demonstrated using a computer screen photo-assisted technique (CSPT). This technique has previously been demonstrated for analyzing fluorescence from 96 wells microtiterplates (200 µl per well) and from a single cuvette with some optics to enhance sensitivity. In this work a custom designed array of wells with a volume of approximately 1 mu;l is used. In order to measure such small volumes without saturating the detector, the transmitted light is masked by placing the sample between two crossed polarizers. This arrangement blocks nearly all the transmitted light, while the emitted light, which is nearly unpolarized, can still be detected. The lowest amount (concentration x volume) of analyte detectable in this setup is about 40 times smaller than in the previous setups.

  • 14. Barkå, Jonas
    et al.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Background compensation in computer screen photo-assisted reflectance fingerprinting2006In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 120, no 1, p. 79-85Article in journal (Refereed)
    Abstract [en]

    The computer screen photo-assisted technique (CSPT) is a method for the classification of colorimetric assays utilizing ordinary computer sets and web cameras as instrumentation. In CSPT measurements the web camera captures the image of the assay under the screen illumination, and typically a spurious spatial distribution of intensities is overlapped on the image. This issue is examined here, focusing on the effect of the sample and illuminating colors on the spatial modulation of intensity. A method for the selection of colors composing an illuminating sequence that minimizes the spatial variability is proposed. The approach is tested for the classification of different color substances showing improvements up to 53% of the intra/inter cluster distance ratio measured in a PCA space, when compared to randomly chosen colors. © 2006 Elsevier B.V. All rights reserved.

  • 15.
    Bjorklund, Robert
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Automatic optimization of experimental conditions for fast evaluation of diagnostic tests using ubiquitous instrumentation2008In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 134, no 1, p. 199-205Article in journal (Refereed)
    Abstract [en]

    Rapid quantitative determinations of creatinine, potassium and glucose, all important parameters in routine medical diagnostics, are demonstrated using a computer screen photo-assisted technique (CSPT). CSPT uses regular computer screens as light sources and web cameras as imaging detectors for supporting optical evaluations of diverse character. The ubiquity and versatility of the setup, makes CSPT an attractive candidate for point of care determinations. A robust procedure for the automatic selection of experimental conditions in CSPT evaluation, including camera channels and illuminating colors that minimize the measuring time up to 5 times is described. The method utilizes the correlation between experimental conditions and classification scores, obtained under a generic 50 color training session, to extract measuring sequences as short as 9 s. The extracted measuring conditions automatically adapted to the different tests provided a general, practical and fast approach for CSPT optimization in real scenarios. © 2008 Elsevier B.V. All rights reserved.

  • 16.
    Bjorklund, Robert
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Generation of illuminating sequences for the computer screen photo-assisted evaluation of creatinine2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster på konferensen " Eurosensors XX, Göteborg, Sweden, 17-20 sept.

  • 17. Comina, German
    et al.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration dagger2015In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 6, no 4, p. 437-451Article in journal (Refereed)
    Abstract [en]

    The unibody lab-on-a-chip (ULOC) concept entails a fast and affordable micro-prototyping system built around a single monolithic 3D printed element (unibody). A consumer-grade stereo lithography (SL) 3D printer can configure ULOCs with different forms of sample delivery, transport, handling and readout, while minimizing material costs and fabrication time. ULOC centralizes all complex fabrication procedures and replaces the need for clean room resources, delivering prototypes for less than 1 US$, which can be printed in 10 min and ready for testing in less than 30 min. Recent examples of ULOC integration of transport, chemical sensing for optical readout and flow mixing capabilities are discussed, as well as the integration of the first check-valves for ULOC devices. ULOC valves are strictly unidirectional up to 100 psi, show an exponential forward flow behavior up to 70 psi and can be entirely fabricated with the ULOC approach.

  • 18.
    Comina, German
    et al.
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Autonomous Chemical Sensing Interface for Universal Cell Phone Readout2015In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 54, no 30, p. 8708-8712Article in journal (Refereed)
    Abstract [en]

    Exploiting the ubiquity of cell phones for quantitative chemical sensing imposes strong demands on interfacing devices. They should be autonomous, disposable, and integrate all necessary calibration and actuation elements. In addition, a single design should couple universally to a variety of cell phones, and operate in their default configuration. Here, we demonstrate such a concept and its implementation as a quantitative glucose meter that integrates finger pumps, unidirectional valves, calibration references, and focusing optics on a disposable device configured for universal video acquisition.

  • 19.
    Comina, German
    et al.
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, The Institute of Technology.
    Low cost lab-on-a-chip prototyping with a consumer grade 3D printer2014In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 14, no 16, p. 2978-2982Article in journal (Refereed)
    Abstract [en]

    Versatile prototyping of 3D printed lab-on-a-chip devices, supporting different forms of sample delivery, transport, functionalization and readout, is demonstrated with a consumer grade printer, which centralizes all critical fabrication tasks. Devices cost 0.57US$ and are demonstrated in chemical sensing and micromixing examples, which exploit established principles from reference technologies.

  • 20.
    Comina, German
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    PDMS lab-on-a-chip fabrication using 3D printed templates2014In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 14, no 2, p. 424-430Article in journal (Refereed)
    Abstract [en]

    The fabrication of conventional PDMS on glass lab-on-a-chip (LOC) devices, using templates printed with a commercial (2299 US$) micro-stereo lithography 3D printer, is demonstrated. Printed templates replace clean room and photolithographic fabrication resources and deliver resolutions of 50 mu m, and up to 10 mu m in localized hindrances, whereas the templates are smooth enough to allow direct transfer and proper sealing to glass substrates. 3D printed templates accommodate multiple thicknesses, from 50 mu m up to several mm within the same template, with no additional processing cost or effort. This capability is exploited to integrate silicone tubing easily, to improve micromixer performance and to produce multilevel fluidics with simple access to independent functional surfaces, which is illustrated by time-resolved glucose detection. The templates are reusable, can be fabricated in under 20 min, with an average cost of 0.48 US$, which promotes broader access to established LOC configurations with minimal fabrication requirements, relieves LOC fabrication from design skills and provides a versatile LOC development platform.

  • 21.
    Comina, German
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering. Not Found:Linkoping Univ, Opt Devices Lab, Dept Phys Chem and Biol IFM, S-58183 Linkoping, Sweden.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Towards autonomous lab-on-a-chip devices for cell phone biosensing2016In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 77, p. 1153-1167Article in journal (Refereed)
    Abstract [en]

    Modern cell phones are a ubiquitous resource with a residual capacity to accommodate chemical sensing and biosensing capabilities. From the different approaches explored to capitalize on such resource, the use of autonomous disposable lab-on-a-chip (LOC) devices conceived as only accessories to complement cell phones underscores the possibility to entirely retain cell phones ubiquity for distributed biosensing. The technology and principles exploited for autonomous LOC devices are here selected and reviewed focusing on their potential to serve cell phone readout configurations. Together with this requirement, the central aspects of cell phones resources that determine their potential for analytical detection are examined. The conversion of these LOC concepts into universal architectures that are readable on unaccessorized phones is discussed within this context. (C) 2015 Elsevier B.V. All rights reserved.

  • 22. Di Natale, C
    et al.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimelli, A.
    Pennazza, G.
    Santonico, M.
    D´Amico, A.
    Paolesse, R.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Ubiquitos chemical sensing and optical imaging for ubiquitos environments2007In: ICRA 2007 Workshop-Robotic olfaction towards real applications,2007, 2007Conference paper (Refereed)
  • 23.
    Di Natale, C
    et al.
    University Roma Tor Vergata.
    Martinelli, E
    University Roma Tor Vergata.
    Paolesse, R
    University Roma Tor Vergata.
    DAmico, A
    University Roma Tor Vergata.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    An artificial olfaction system based on the optical imaging of a large array of chemical reporters2009In: SENSORS AND ACTUATORS B-CHEMICAL, ISSN 0925-4005, Vol. 142, no 2, p. 412-417Article in journal (Refereed)
    Abstract [en]

    Electronic noses are object of research since more than two decades; nonetheless. the analogies between natural and olfaction systems are still limited to the selectivity properties of the receptors. The implementation of more sophisticated features such as the large number of receptors and the glomeruli layer have been hampered by technical difficulties related to the management of a large number of contemporaneous signals. As demonstrated in the past, optical imaging is a read-out technique for sensors development that can provide large sensor arrays. In this paper an artificial olfaction system based on the imaging of a continuous layer of chemical indicators is illustrated. The system incorporates an array of thousands of sensors, corresponding to the pixels of the image. The choice of Computer Screen Photoassisted Technology as a platform for optical interrogation of the sensing layer allows for the definition of a strategy for an automatic definition of a glomeruli layer based on the classification of the optical fingerprints of the image pixels. Chemical indicators were dissolved into a polymeric matrix providing the further property of odor diffusion mimicking the functions of the olfactory mucosa. The system has been tested in a simple experiment and data have been treated applying a lateral inhibition to the glomeruli layer resulting in a dynamic pattern resembling that observed in natural olfaction.

  • 24.
    Di, Natale C.
    et al.
    Di Natale, C., Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
    Martinelli, E.
    Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
    Paolesse, R.
    Department of Chemical Science and Technology, University of Rome Tor Vergata, Rome, Italy.
    D'Amico, A.
    Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    An experimental biomimetic platform for artificial olfaction2008In: PLoS ONE, ISSN 1932-6203, Vol. 3, no 9Article in journal (Refereed)
    Abstract [en]

    Artificial olfactory systems have been studied for the last two decades mainly from the point of view of the features of olfactory neuron receptor fields. Other fundamental olfaction properties have only been episodically considered in artificial systems. As a result, current artificial olfactory systems are mostly intended as instruments and are of poor benefit for biologists who may need tools to model and test olfactory models. Herewith, we show how a simple experimental approach can be used to account for several phenomena observed in olfaction. An artificial epithelium is formed as a disordered distributed layer of broadly selective color indicators dispersed in a transparent polymer layer. The whole epithelium is probed with colored light, imaged with a digital camera and the olfactory response upon exposure to an odor is the change of the multispectral image. The pixels are treated as olfactory receptor neurons, whose optical properties are used to build a convergence classifier into a number of mathematically defined artificial glomeruli. A non-homogenous exposure of the test structure to the odours gives rise to a time and spatial dependence of the response of the different glomeruli strikingly similar to patterns observed in the olfactory bulb. The model seems to mimick both the formation of glomeruli, the zonal nature of olfactory epithelium, and the spatio-temporal signal patterns at the glomeruli level. This platform is able to provide a readily available test vehicle for chemists developing optical indicators for chemical sensing purposes and for biologists to test models of olfactory system organization. © 2008 Di Natale et al.

  • 25. Di Natale, C.
    et al.
    Paolesse, R.
    Alimelli, A.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    D´Amico, A.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    A novel gas-chromatography based sensor array: CSPT imaging of time resolved diffusion of gases in porphyrins embedded polymers2007In: IEEE Sensors 2007,2007, 2007Conference paper (Refereed)
  • 26. Di Natale, C.
    et al.
    Pennazza, G.
    Santonico, M.
    Alimelli, A.
    Paolesse, R.
    D.Amico, A.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    A hybrid sensor array based on optical and mass transducers2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster på konferensen "Eurosensors XX", Göteborg, Sweden, 17-20 sept.

  • 27.
    Di Natale, Corrado
    et al.
    University Roma Tor Vergata.
    Santonico, Marco
    University Roma Tor Vergata.
    Paolesse, Roberto
    University Roma Tor Vergata.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Evaluation of the performance of sensors based on optical imaging of a chemically sensitive layer2010In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY, ISSN 1618-2642, Vol. 397, no 2, p. 613-621Article in journal (Refereed)
    Abstract [en]

    Interest in the use of the optical properties of chemical indicators is growing steadily. Among the optical methods that can be used to capture changes in sensing layers, those producing images of large-area devices are particularly interesting for chemical sensor array development. Until now, few studies addressed the characterization of image sensors from the point of view of their chemical sensor application. In this paper, a method to evaluate such performance is proposed. It is based on the simultaneous measurement of absorption events in a metalloporphyrin layer with an image sensor and a quartz microbalance (QMB). Exploiting the well-known behaviour of QMB, comparison of signals enables estimation of the minimum amount of absorbed molecules that the image sensor can detect. Results indicate that at the single pixel level a standard image sensor (for example a webcam) can easily detect femtomoles of absorbed molecules. It should therefore be possible to design sensor arrays in which the pixels of images of large-area sensing layers are regarded as individual chemical sensors providing a ready and simple method for large sensor array development.

  • 28.
    Dini, Francesca
    et al.
    University Roma Tor Vergata.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Paolesse, Roberto
    University Roma Tor Vergata.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Di Natale, Corrado
    University Roma Tor Vergata.
    Polymers with embedded chemical indicators as an artificial olfactory mucosa2010In: ANALYST, ISSN 0003-2654, Vol. 135, no 6, p. 1245-1252Article in journal (Refereed)
    Abstract [en]

    Physiological investigations suggest that the olfactory mucosa probably plays an ancillary role in the recognition of odours introducing a sort of chromatographic separation that, together with the zonal distribution of olfactory receptors, gives place to selective spatio-temporal response patterns. It has been recently suggested that this behaviour may be simulated by chemical sensors embedded in continuous polymer layers. In this paper, in analogy to the biology of olfaction, a simple and compact platform able to separate and detect gases and vapours on the basis of their diffusion properties is proposed. In such a system, broadly selective colour indicators, such as metalloporphyrins, are embedded in continuous layers of polymers with different sorption properties. The exposure to various alcohols and amines shows that the porphyrins are mainly responsible for the recognition of the molecular family, while the occurring spatio-temporal signal patterns make possible the identification of the individual chemical species.

  • 29.
    Dini, Francesca
    et al.
    University of Roma Tor Vergata, Italy .
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Paolesse, Roberto
    University of Roma Tor Vergata, Italy .
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
    Di Natale, Corrado
    University of Roma Tor Vergata, Italy .
    Computer screen assisted digital photography2013In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 179, no SI, p. 46-53Article in journal (Refereed)
    Abstract [en]

    The computer screen photo-assisted techniques (CSPT) have been developed during the last 10 years through an extensive collaboration between University of Rome "Tor Vergata" and Linkoping University in Sweden. CSPT has thus evolved into a concept we now call computer screen assisted digital photography, yielding detailed information about the interaction between color indicators and (volatile) analytes. In the present paper, we give a brief summary of the CSPT concept and its connection to digital photography. We concentrate, however, on the most recent results, which were obtained by using most of the degrees of freedom offered by a computer screen as a light source and a digital (web) camera as a detector. Thus, we describe in detail recent experiments on cotton yarns impregnated with color indicators for volatile organic molecules. The interaction between the color indicators and molecules, like trimethylamine, was investigated by CSPT in high dynamic imaging together with a background noise limiting algorithm. It is shown that the simultaneous use of the last two additions to the CSPT concept considerably enhances the chemical sensing ability of CSPT. It is concluded that the collaboration between Rome and Linkoping has generated a useful platform for further developments of chemical analysis with a ubiquitous instrumentation, a (computer) screen and a web camera. This technique is aimed at facilitating the assembly of opto-chemical sensors with evident benefits in the reduction of cost of sensor systems and in an increased integrability with the existent telecommunication infrastructures.

  • 30.
    Dini, Francesca
    et al.
    University of Roma Tor Vergata.
    Martinelli, Eugenio
    University of Roma Tor Vergata.
    Paolesse, Roberto
    University of Roma Tor Vergata.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Schild, Detlev
    University of Gottingen.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
    Di Natale, Corrado
    University of Roma Tor Vergata.
    Data processing for image-based chemical sensors: unsupervised region of interest selection and background noise compensation2012In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 402, no 2, p. 823-832Article in journal (Refereed)
    Abstract [en]

    Natural olfaction suggests that numerous replicas of small sensors can achieve large sensitivity. This concept of sensor redundancy can be exploited by use of optical chemical sensors whose use of image sensors enables the simultaneous measurement of several spatially distributed indicators. Digital image sensors split the framed scene into hundreds of thousands of pixels each corresponding to a portion of the sensing layer. The signal from each pixel can be regarded as an independent sensor, which leads to a highly redundant sensor array. Such redundancy can eventually be exploited to increase the signal-to-noise ratio. In this paper we report an algorithm for reduction of the noise of pixel signals. For this purpose, the algorithm processes the output of groups of pixels whose signals share the same time behavior, as is the case for signals related to the same indicator. To define these groups of pixels, unsupervised clustering, based on classification of the indicator colors, is proposed here. This approach to signal processing is tested in experiments on the chemical sensitivity of replicas of eight indicators spotted on to a plastic substrate. Results show that the groups of pixels can be defined independently of the geometrical arrangement of the sensing spots, and substantial improvement of the signal-to-noise ratio is obtained, enabling the detection of volatile compounds at any location on the distributed sensing layer.

  • 31.
    Dini, Francesca
    et al.
    University Roma Tor Vergata.
    Martinelli, Eugenio
    University Roma Tor Vergata.
    Pomarico, Giuseppe
    University Roma Tor Vergata.
    Paolesse, Roberto
    University Roma Tor Vergata.
    Monti, Donato
    University Roma Tor Vergata.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Di Natale , Corrado
    University Roma Tor Vergata.
    Chemical sensitivity of self-assembled porphyrin nano-aggregates2009In: NANOTECHNOLOGY, ISSN 0957-4484 , Vol. 20, no 5, p. 055502-Article in journal (Refereed)
    Abstract [en]

    Nanostructured molecular assemblies may provide additional sensing properties not found in other arrangements of the same basic constituents. Among three-dimensional structures, nanotubes are particularly appealing for applications as chemical sensors, because of the potential inclusion of different guests inside the cavity or the induced modification of the skeletal interaction after analyte binding. Porphyrins are a class of compounds characterized by brilliant sensing properties, appearing also in non-ordered solid-state aggregates. In recent years, it was reported that aggregation of oppositely charged porphyrins led to the formation of self-assembled nanotubes and in this paper their sensing properties, both in solution and in the solid state, have been investigated.

    The interactions of porphyrin nanotubes with guest molecules have been monitored by following the changes in their UV-vis spectra. The results obtained have been exploited to build up a sensing platform based on a computer screen as a light source and a digital camera as detector.

    Porphyrin nanostructures exhibited an enhanced sensitivity to different compounds with respect to those shown by single porphyrin subunits. The reason for the increased sensitivity may be likely found in an additional sensing mechanism related to the modulation of the strength of the forces that keep the supramolecular ensemble together.

  • 32.
    Fallqvist, Amie
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Macken, Stephen
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, Faculty of Science & Engineering.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Optically addressable field effect nano-environments for chemical imaging2009In: Procedia Chemistry, ISSN 1876-6196, Vol. 1, no 1, p. 224-227Article in journal (Refereed)
    Abstract [en]

    An optically addressable field effect device Incorporating functionalized nano-environments is demonstrated for the generation of multiple response signatures of a same analyte-sensing material combination. The device can operate unsupervised and different response mechanism can be simultaneously tested and incorporated in a multidimensional response. This proof of concept explores the well-known Pd-H-2 case, while the concept is a breadboard for chemical imaging experiments.

  • 33.
    Filippini, D.
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Fraigi, L.
    Laboratorio de Sensores, CITEI-National Institute of Industrial Technology, CC 157, 1650 San Martín, Argentina.
    Aragon, R.
    Aragón, R., Laboratorio de Películas Delgadas, Fac. de Ing., Univ. de Buenos Aires and PRINSO-CONICET-CITEFA, Paseo Colon 850, 1063 Cap. Fed., Argentina.
    Weimar, U.
    Institute of Physical and Theoretical Chemistry, University of Tübingen, auf der Morgenstelle 8, D-72076 Tübingen, Germany.
    Thick film Au-gate field-effect devices sensitive to NO22002In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 81, no 2-3, p. 296-300Article in journal (Refereed)
    Abstract [en]

    Screen printed thick film gold gate MOS capacitors are selectively sensitive to the presence of NO2 in air. Metallo-organic gold inks produce open gate structures, with positive flat-band-voltage shifts of 2.72mV/ppm at 140ppm of NO2 in air, comparable to PVD deposited thin film devices. Standard gold pastes are denser, coarser grained thick films of alloyed composition, which reverse the polarity of the flat-band-voltage shift. No cross sensitivity to H2 or NO is apparent. © 2002 Elsevier Science B.V. All rights reserved.

  • 34.
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Optochemical sensing with ubiquitos platforms2007In: Optik i Sverige 2007,2007, 2007Conference paper (Refereed)
  • 35.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimeli, Adriano
    Università degli Studi di Roma Tor Vergata.
    Di Natale, Corrado
    Dipartiment di Ingegneria Elettronica Università degli Studi di Roma Tor Vergata.
    Paolesse, Roberto
    Università degli Studi di Roma Tor Vergata.
    DAmico, Arnaldo
    Università degli Studi di Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical Sensing with Familiar Devices2006In: Angewandte Chemie : : a journal of the Gesellschaft Deutscher Chemiker.. International edition, Vol. 45, no 23, p. 3800-3803Article in journal (Refereed)
  • 36.
    Filippini, Daniel
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Andersson, Tony
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Svensson, Samuel
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, Faculty of Health Sciences.
    Microplate based biosensing with a computer screen aided technique2003In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 19, no 1, p. 35-41Article in journal (Refereed)
    Abstract [en]

    Melanophores, dark pigment cells from the frog Xenopus laevis, have the ability to change light absorbance upon stimulation by different biological agents. Hormone exposure (e.g. melatonin or α-melanocyte stimulating hormone) has been used here as a reversible stimulus to test a new compact microplate reading platform. As an application, the detection of the asthma drug formoterol in blood plasma samples is demonstrated. The present system utilizes a computer screen as a (programmable) large area light source, and a standard web camera as recording media enabling even kinetic microplate reading with a versatile and broadly available platform, which suffices to evaluate numerous bioassays. Especially in the context of point of care testing or self testing applications these possibilities become advantageous compared with highly dedicated comparatively expensive commercial systems.

  • 37.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Fingerprinting of fluorescence substances for diagnostic purposes using computer screen illumination2004In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 106, p. 302-310Article in journal (Refereed)
  • 38.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Fingerprinting of fluorescent substances for diagnostic purposes using computer screen illumination2005In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 106, p. 302-310Article in journal (Refereed)
  • 39.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Comina, G.
    Thin Films Laboratory, Science Faculty, Universidad Nacional De Ingenieria, Lima 31, Peru.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-assisted reflectance fingerprinting2005In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 107, no 2, p. 580-586Article in journal (Refereed)
    Abstract [en]

    The characterization of opaque color samples using reflected light is demonstrated with a computer screen photo-assisted technique (CSPT). CSPT utilizes standard computer screens as light sources and conventional web cameras as detectors to perform colorimetric or fluorescent evaluations that retain key spectral features of the tested substances. In this work, the fingerprinting of samples spectral reflectances is achieved by evaluating the reflected light under controlled computer screen illumination. Two different methods for processing of features are investigated, revealing complementary properties for classifications purposes. The attainable classification enables to distinguish different colors from just hues of a same color. © 2004 Elsevier B.V. All rights reserved.

  • 40.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Comina, G.
    Thin Films Laboratory Universidad National de Ingenieria, Lima, Peru.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Computer screen photo-assisted reflectance fingerprinting2004In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 107, p. 580-586Article in journal (Refereed)
  • 41.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, C.
    Paolese, R.
    Alimelli, A.
    DAmico, A.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Home and global (bio) chemical sensing with computer screen photo-assisted techniques2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Konferensbidrag (muntligt) på 11th World congress on internet in medicine - Mednet 2006, Toronto, Canada, 14-19 okt.

  • 42.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, C
    Paolesse, R
    D´Amico, A.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Distributed chemical monitoring for safety and security with computer screen photo-assissted techniques2007In: Safety and Security in Europe 2007,2007, 2007Conference paper (Refereed)
  • 43.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, Corrado
    University of Rome, Italy.
    Paolesse, R
    Univresity of Rome, Italy.
    D´Amico, A.
    University of Rome, Italy.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-assisted techniques for global monitoring of environmental and sanitary parameters2007In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 121, no 1, p. 93-102Article in journal (Refereed)
    Abstract [en]

    The computer screen photo-assisted technique (CSPT) is a measuring method that uses regular computer screens as controlled light sources and web cameras as imaging detectors for optical evaluations of sensing substances, which optical properties respond to target analytes. The fact, that CSPT uses a globally distributed and familiar infrastructure as instrumentation and that is able to serve multiple targets with the same setup, makes it an attractive candidate for home testing. This article reviews the CSPT concept and focuses in two recent studies that demonstrate thorough CSPT determinations using a handy and eventually disposable assay format, with the potential to be as ubiquitous as the CSPT platforms themselves. The implications of such combination of technologies is discussed, and its potential to support the global monitoring of environmental and sanitary parameters, using Internet geography browsers, is analyzed. © 2006 Elsevier B.V. All rights reserved.

  • 44.
    Filippini, Daniel
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Gatto, Emanuela
    University Roma Tor Vergata.
    Alimelli, Adriano
    University Roma Tor Vergata.
    Ali Malik, Muhammad
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Di Natale, Corrado
    University Roma Tor Vergata.
    Paolesse, Roberto
    University Roma Tor Vergata.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Spectral fingerprinting of porphyrins for distributed chemical sensing2009In: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, ISSN 1088-4246, Vol. 13, no 1, p. 77-83Article in journal (Refereed)
    Abstract [en]

    Recent progress in spectral fingerprinting of fluorescent indicators using distributed instrumentation based on consumer electronic devices is reviewed. In particular, the evaluation of disposable assays using a computer screen photo-assisted technique (CSPT) is discussed. Sample identification and optimization strategies are analyzed as well as the underlying theoretical background for polychromatic spectral fingerprinting.

  • 45.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Gunnarsson, J.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical image generation with a grid-gate device2004In: Journal of Applied Physics, ISSN 0021-8979, E-ISSN 1089-7550, Vol. 96, no 12, p. 7583-7590Article in journal (Refereed)
    Abstract [en]

    Scanning light pulse technique generating distinctive chemical images of diverse gases is demonstrated using a sensing arrangement that allows unrestricted choice of sensing materials, disregarding its conductivity or morphology. The present device, a metal oxide semiconductor structure, disentangles biasing from chemical functions by providing an inert grid as a gate that supplies the proper biasing, while functional materials even in the form of disconnected clusters can be used for sensing. The reading of conductimetric chemical responses of clustered materials, in nominal operating conditions, is demonstrated by the generation of chemical images acquired for inversion biasing conditions. © 2004 American Institute of Physics.

  • 46.
    Filippini, Daniel
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Liedberg, Bo
    Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics . Linköping University, The Institute of Technology.
    SENSORS and ACTUATORS B: Chemical Special Issue: in SENSORS AND ACTUATORS B-CHEMICAL, vol 142, issue 2, pg 4052009Other (Other academic)
    Abstract [en]

    n/a

  • 47.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Adaptive illumination in computer screen assisted spectral fingerprinting2005In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 86, no 8, p. 084101-Article in journal (Refereed)
    Abstract [en]

    The computer screen photoassisted technique (CSPT) uses displays as controlled light sources for measuring spectral fingerprints of color substances, such as those present in bioassays. Here, the possibility of tuning the illuminating sequences for matching CSPT fingerprints with target spectral transmittances is demonstrated. This approach enables robust classification, orders of magnitude form mismatches, and establish a systematic method for adapting optimum illuminating sequences to any unknown measuring platform. © 2005 American Institute of Physics.

  • 48.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical images generated by large area homogeneous illumination of metal-insulator-semiconductor structures2003In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 82, no 21, p. 3791-3793Article in journal (Refereed)
    Abstract [en]

    The induction of distinctive chemical images in the field-effect devices upon gas exposure by the use of a controlled large area illumination provided by a computer screen was reported. To generate two-dimensional photocurrent images, the concurrent optical and chemical modulation of the semiconductor surface potential of a single metal-oxide-semiconductor capacitor was used. It was concluded that the use of a computer screen as a programmable light source simplifies a normally complex setup.

  • 49.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical imaging by a computer screen aided scanning light pulse technique2002In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 81, no 20, p. 3891-3893Article in journal (Refereed)
    Abstract [en]

    The demonstration of a scanning light pulse technique (SLPT) for the generation of selective chemical images was done. The programmable light source provided by a standard cathode-rays tube computer screen was used for this purpose. The testing of the concept was done with a metal-oxide-semiconductor capacitor with catalytic gates of platinum and palladium spatially distributed in transversal directions.

  • 50.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical sensing with computer screen photo-assisted techniques2005In: Eurosensors XIX,2005, 2005Conference paper (Refereed)
123 1 - 50 of 109
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