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  • 1.
    Alkaissi, Aidah
    et al.
    Linköping University, Department of Medicine and Health Sciences, Anesthesiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Intensive Care UHL.
    Ledin, Torbjörn
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Ödkvist, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Kalman, Sigga
    Linköping University, Department of Medicine and Health Sciences, Anesthesiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Anaesthesiology and Intensive Care VHN.
    P6 acupressure increases tolerance to nausogenic motion stimulation in women with high risk for PONV2005In: Canadian Journal of Anesthesia, ISSN 1496-8975, Vol. 52, p. 703-709Article in journal (Refereed)
    Abstract [en]

    Purpose: In a previous study we noticed that P6 acupressure decreased postoperative nausea and vomiting (PONV) more markedly after discharge. As motion sickness susceptibility is increased by, for example, opioids we hypothesized that P6 acu-pressure decreased PONV by decreasing motion sickness susceptibility. We studied time to nausea by a laboratory motion challenge in a group of volunteers, during P6 and placebo acupressure.

    Methods: 60 women with high and low susceptibilities for motion sickness participated in a randomized and double-blind study with an active P6 acupressure, placebo acupressure, and a control group (n = 20 in each group). The risk score for PONV was over 50%. The motion challenge was by eccentric rotation in a chair, blindfolded and with chin to chest movements of the head. The challenge was stopped when women reported moderate nausea. Symptoms were recorded.

    Results: Mean time to moderate nausea was longer in the P6 acu-pressure group compared to the control group. P6 acupressure = 352 (259–445), mean (95% confidence interval) in seconds, control = 151 (121–181) and placebo acupressure = 280 (161–340); (P = 0.006). No difference was found between P6 and placebo acupressure or placebo acupressure and control groups. Previous severity of motion sickness did not influence time to nausea (P = 0.107). The cumulative number of symptoms differed between the three groups (P < 0.05). Fewer symptoms were reported in the P6 acupressure compared to the control group P < 0.009. Overall, P6 acupressure was only marginally more effective than placebo acupressure on the forearms.

    Conclusion: In females with a history of motion sickness P6 acu-pressure increased tolerance to experimental nauseogenic stimuli, and reduced the total number of symptoms reported.

  • 2.
    Aschan, Gunnar
    et al.
    Linköping University.
    Bunnfors, Irja
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Experimentella studier över industriellt använda lösningsmedels toxicitet på balanssinnet i centrala nervsystemet1979Report (Other academic)
  • 3.
    Aschan, Gunnar
    et al.
    Linköping University.
    Bunnfors, Irja
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Experimentella studier över industriellt använda lösningsmedels toxicitet på balanssinnet i centrala nervsystemet1982Report (Other academic)
  • 4.
    Aschan, Gunnar
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Bunnfors, Irja
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Xylene exposure. Electronystagmografic and gaschromatografic studies in rabbit1977In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 84, no 1-6, p. 370-376Article in journal (Refereed)
    Abstract [en]

    Complaints of vertigo from people who are exposed to industrial solvents have focused interest on their toxic effect on the nervous system. In order to evaluate the influence of an organic solvent, xylene, on the mammalian vestibular system, a series of rabbit experiments were performed. To achieve a constant concentration, the xylene was infused as a lipid emulsion. Blood concentrations were estimated by gas chromatography. Elec-tronystagmography in darkness revealed that at blood xylene concentrations of 30 ppm all rabbits had a positional nystagmus. The beat direction was the opposite of positional alcohol nystagmus. Another difference between the alcohol and the xylene reaction was that rotatory nystagmus responses were exaggerated. The relations between the present findings and the reactions and blood concentrations in people exposed to industrial solvents are discussed.

  • 5.
    Aschan, Gunnar
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Lösningsmedels toxicitet på balanssinnet i centrala nervsystemet. Experimentella studier på kanin1979Report (Other academic)
  • 6.
    Aschan, Gunnar
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Påverkan av vestibularissystemet i en djurexperimentell modell1977In: Svensk Otolaryngol förening, ISSN 0280-7939, Vol. 1, no 2, p. 1-4Article in journal (Other academic)
  • 7.
    Bergenius, Johan
    et al.
    Karolinska Institutet.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Möller, Claes
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Frenzels brillor eller datoriserad otoneurologi1990Conference paper (Other academic)
  • 8.
    Ekblad, Sara
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Lönnberg, Barbro
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Berg, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Ödkvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Ledin, Torbjörn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Hammar, Mats
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Estrogen effects on postural balance in postmenopausal women without vasomotor symptoms: A randomized masked trial2000In: Obstetrics and Gynecology, ISSN 0029-7844, E-ISSN 1873-233X, Vol. 95, no 2, p. 278-283Article in journal (Refereed)
    Abstract [en]

    Objective: To assess whether estrogen treatment given to postmenopausal women without vasomotor symptoms improves balance more than placebo. Methods: Forty healthy postmenopausal women without vasomotor symptoms were randomized to transdermal 17▀-estradiol (E2) 50 ╡g/day for 14 weeks or identical transdermal placebo patches. Postural balance was measured with dynamic posturography before and after 4, 12, and 14 weeks of therapy. In this test, the visual, vestibular, and somatosensory systems were provoked with increasing difficulty and body sway was measured with a dual forceplate. A low score showed large sway and a score of 100 showed no sway at all. Results: Thirty-eight women completed the study. Both groups had normal balance for their ages and near maximum scores in the three easier balance tests at baseline. In the most difficult test, both groups improved their postural balance significantly (from 13 to 32 and from 22 to 39, respectively) after 4 weeks. Thereafter, no change was seen. One problem was low statistical power, but the relative change in balance did not differ between groups. The comparison did not show even a minute advantage of E2 over placebo, so a study with higher power would probably not have shown a more pronounced effect of estrogen than placebo. The change over time did not differ between groups, which indicates a significant learning effect.Conclusion: In women without vasomotor symptoms, estrogen therapy did not seem to increase postural balance significantly more than placebo. However, we could not rule out that estrogens affect postural balance in women with vasomotor symptoms. Copyright (C) 2000 The American College of Obstetricians and Gynecologists.

  • 9.
    Grahn Kronhed, Ann-Charlotte
    et al.
    Linköping University, Department of Medicine and Health Sciences, Division of Preventive and Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences.
    Hallberg, Inger
    Linköping University, Department of Medicine and Health Sciences, Nursing Science. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Möller, Margareta
    Centre for Health Care Sciences, Örebro University Hospital.
    Effect of training on health-related quality of life, pain and falls in osteoporotic women2009In: Advances in Physiotherapy, ISSN 1403-8196, E-ISSN 1651-1948, Vol. 11, no 3, p. 154-165Article in journal (Refereed)
    Abstract [en]

    Physical inactivity is a risk factor for osteoporosis and fractures. The aim of the study was to see if supervised training would improve health-related quality of life (HRQL), reduce pain and falls in osteoporotic women. Women with established osteoporosis (n=124) were invited to a 1-year, follow-up study. Seventy-three women aged 60-81 years met the inclusion criteria and were randomized to an exercise (E) or control (C) group. A 4-month, supervised group training programme was designed. Participants were studied using HRQL questionnaires, clinical tests and dynamic posturography. Thirty-one women in the E-group and 34 women in the C-group completed the study. The E-group improved in six SF-36 domains and mental component summary (MCsum) index and also in worst pain intensity (p<0.01) after the supervised exercise training. Differences were found between the groups when comparing changes in four SF-36 domains, MCsum and worst pain (p=0.001). Physical activity level decreased in the E-group after the supervised period. Mean time to first fall occurred earlier in the C-group than in the E-group for the first 4 months but the trend did not last for the 1-year follow-up. The study suggests that supervised group training is beneficial for women with established osteoporosis.

  • 10. Gripmark, M.
    et al.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University.
    Perceived subjective horizontal during eccentric rotatory testing1995In: NES, 1995, 1995Conference paper (Other academic)
  • 11.
    Hagert, Britt
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Nursing Science.
    Wahren, Lis Karin
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Wikblad, K
    Ödkvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Hälsorelaterad livskvalité hos personer opererade för snarkning1999In: Hälso- och sjukvårdsstämman,1999, Stockholm: Vårdförb. SHSTF , 1999Conference paper (Other academic)
  • 12.
    Hagert, Britt
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Nursing Science.
    Wahren, Lis Karin
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Wikblad, K
    Ödkvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Patients' and cohabitants' reports on snoring and daytime sleepiness, 1-8 years after surgical treatment of snoring.1999In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, E-ISSN 1423-0275, Vol. 61, p. 19-24Article in journal (Refereed)
  • 13.
    Hagert, Britt
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Nursing Science.
    Wikblad, K
    Ödqvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery.
    Wahren, Lis Karin
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Side effects after surgical treatment of snoring2000In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, E-ISSN 1423-0275, Vol. 62, no 2, p. 76-80Article in journal (Refereed)
    Abstract [en]

    In a questionnaire study detailed side effects after snoring surgery were examined in 415 individuals 2-8 years after surgery. Three years later a new questionnaire was answered by those with side effects affecting taste, smell and voice (n = 74). At the first follow-up 255 had side effects of globus, regurgitation, taste, smell and voice. The globus was the most common (40%). In all spheres except the globus, a significant improvement was seen 3 years later. However, pharyngeal dryness and phlegm had a reported frequency of nearly 60%. No significant differences were seen between the uvulopalatopharyngoplasty and laser uvulopalatoplasty methods. Taste disturbances might be due to surgical damage to the nerves or oral dryness. The olfactory impairment present in 7 patients still needs to be explained.

  • 14.
    Hedin-Skogman, Barbro
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Croner, Stefan
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Ödkvist, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Acute facial palsy in children - a 2-year follow-up study with focus on Lyme neuroborreliosis2003In: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, Vol. 67, no 6, p. 597-602Article in journal (Refereed)
    Abstract [en]

    Objective: Acute facial palsy in children is believed to be a rather benign neurological condition. Follow-up-studies are sparse, especially including a thorough otoneurological re-examination. The aim of this study was to examine children with a history of facial palsy in order to register the incidence of complete recovery and the severity and nature of sequelae. We also wanted to investigate whether there was a correlation between sequelae and Lyme Borreliosis, treatment or other health problems.

    Methods: Twenty-seven children with a history of facial palsy were included. A re-examination was performed by an Ear-Nose-Throat (ENT) specialist 1–2.9 years (median 2) after the acute facial palsy. The otoneurological examination included grading the three branches of the facial nerve with the House-Brackman score, otomicroscopy and investigation with Frenzel glasses. A paediatrician interviewed the families. Medical files were analysed.

    Result: The incidence of complete recovery was 78% at the 2-year follow-up. In six out of 27 children (22%), the facial nerve function was mildly or moderately impaired. Four children reported problems with tear secretion and pronunciation. There was no correlation between sequelae after the facial palsy and gender, age, related symptoms, Lyme neuroborreliosis (NB), treatment, other health problems or performance.

    Conclusion: One fifth of children with an acute facial palsy get a permanent dysfunction of the facial nerve. Other neurological symptoms or health problems do not accompany the sequelae of the facial palsy. Lyme NB or treatment seems to have no correlation to clinical outcome. Factors of importance for complete recovery after an acute facial palsy are still not known.

  • 15.
    Hydén, Dag
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden).
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden).
    Schwartz, D. W. F.
    University of Toronto, Ontario, Canada.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden).
    Quantification of slow compensatory eye movements in patients with bilateral vestibular loss: A Study with a Broad Frequency-band Rotatory Test1983In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 96, no 3-4, p. 199-206Article in journal (Refereed)
  • 16.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Thell, Jan
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköping University.
    Rotatory test results in patients with acoustic tumours before and after surgery1987In: / [ed] Pirodda E, Pompeiano O., 1987, p. 118-118Conference paper (Other academic)
  • 17.
    Hydén, Dag
    et al.
    Linköping University. Department of Otalaryngology, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otalaryngology, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otalaryngology, Linköping University, Linköping, Sweden.
    Broad frequency rotatory testing1988In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 105, no s455, p. 48-52Article in journal (Refereed)
    Abstract [en]

    The method of broad-frequency-band rotatory testing with results from normal subjects and patients with peripheral uni- and bilateral loss as well as central vestibular disorders are reviewed. The following conclusions are drawn: adequate testing of the vestibulo-ocular reflex including side detection of unilateral loss in light or in darkness can only be done with either random or high-frequency (2.5–3 Hz) sinusoidal stimulation. Measurements of compensatory eye movements at lower frequencies where vestibular and non-vestibular signals interact are of interest for central vestibular diagnosis. A decreased ability to suppress vestibular nystagmus is not an uncommon finding in patients with large acoustic neuromas or pathology in the brainstem or cerebellum.

  • 18.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Clinical value of the broad spectrum rotatory test1995In: NES,1995;10, 1995, p. 303-309Conference paper (Other academic)
  • 19.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Klinisk applikation av ett bredfrekvent rotationstest1982In: Sv Otolaryngol förening 1982;2, 1982Conference paper (Other academic)
  • 20.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Objective measurement of vestibular compensation1993In: NES, 1993, 1993Conference paper (Other academic)
  • 21.
    Hydén, Dag
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Quantification of compensatory eye movements in light and darkness1984In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 96, no s406, p. 209-211Article in journal (Refereed)
    Abstract [en]

    A broad frequency-band rotatory test has been used to quantify compensatory eye movements in 13 healthy subjects during light and darkness conditions. Eye movements were recorded by EOG. Head movements were recorded either by a potentiometer attached to the chair's axis of rotation or by an angular rate sensor attached to a bite-board. Gain and phase values between eye and head velocity were calculated. A systematic error in the higher frequency range is introduced in the results by assuming head movement equal to chair movement. Different instructions in the dark can alter the gain values at lower frequencies (up to 2 Hz) during sinusoidal stimulation. During pseudorandom stimulation no such differences can be obtained. During all test conditions with the rate sensor the gain values approach unity at about 3 Hz.

     

  • 22.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    The oscillatory test in patient with bilateral vestibular loss1982In: Nordic symposium on data processing of eye movements, 1982, p. 21-22Conference paper (Other academic)
  • 23.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Visual suppression tests in diagnosis of of diseases of the central nervous system1983In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 30, p. 205-209Article in journal (Refereed)
  • 24.
    Hydén, Dag
    et al.
    Linköping University. Department of Otolaryngology, Linköping University, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, Linköping University, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, Linköping University, Sweden.
    Möller, Claes
    Östergötlands Läns Landsting. Department of Otolaryngology, Linköping University, Sweden.
    Visual suppression tests in acoustic neuroma patients1989In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 108, no s468, p. 349-351Article in journal (Refereed)
    Abstract [en]

    Fifty-five patients with a unilateral acoustic neuroma were investigated preoperatively with visual suppression tests during rotatory oscillation and caloric irrigation. During a sinusoidal oscillation, 29% of the patients showed a reduced suppression compared to 9% during pseudo-random oscillation and 11% in the caloric test. In the sinusoidal and caloric tests the majority of the patients with deficient suppression had large or medium-sized tumors. In a few patients with small tumors, pathology was observed in both sinusoidal and randomized tests, presumably as a sign of unconcentration. The study shows that the sinusoidal visual suppression test and to a lesser degree suppression during caloric irrigation are of value for identification of brainstem-cerebellum compression of acoustic neuromas.

  • 25.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköping University.
    Visual Suppression Tests in Aucustic Neuroma Patients1988Conference paper (Other academic)
  • 26.
    Hydén, Dag
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Tham, Richard
    Linköping University.
    Impairment of visuo-vestibular interaction in humans exposed to toluene1983In: Journal for Oto-Rhino-Laryngology, Head and Neck Surgery, ISSN 0301-1569, Vol. 45, no 5, p. 262-269Article in journal (Refereed)
    Abstract [en]

    15 healthy volunteers were investigated in a vestibulo-oculomotor test battery during toluene exposure. The concentration was comparable to the threshold limit value. The results were compared to an identical air experiment. The intoxication caused an impaired visual suppression during a pseudo-random oscillatory swing test and also an increased saccade speed. Other vestibular-oculomotor parameters were normal. The findings are in accordance with our earlier study on styrene in humans, showing that the visual suppression test and the saccade test are sensitive parameters assessing neurotoxic influences by organic solvents.

  • 27.
    Kammerlind, Ann-Sofi C.
    et al.
    Ryhov County Hospital.
    Ledin, Torbjörn
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of ENT - Head and Neck Surgery UHL.
    Ödkvist, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of ENT - Head and Neck Surgery UHL.
    Skargren, Elisabeth
    Linköping University, Department of Medical and Health Sciences, Physiotherapy. Linköping University, Faculty of Health Sciences.
    Recovery after acute unilateral vestibular loss and predictors for remaining symptoms2011In: American Journal of Otolaryngology, ISSN 0196-0709, E-ISSN 1532-818X, Vol. 32, no 5, p. 366-375Article in journal (Refereed)
    Abstract [en]

    Purpose: The aims of this study were to follow recovery during the first 6 months after acute unilateral vestibular loss (AUVL) and to determine predictors for self-rated remaining symptoms. Materials and methods: Forty-two subjects were included less than 10 days after AUVL. Static and dynamic clinical balance tests, visual analogue scales, University of California Los Angeles Dizziness Questionnaire, Dizziness Beliefs Scale, European Quality of Life questionnaire, Dizziness Handicap Inventory, and Hospital Anxiety and Depression Scale were performed at inclusion and at 7 follow-ups over 6 months. Subjects rated their symptoms on visual analogue scales daily at home. Videonystagmography was performed in the acute stage and after 10 weeks. Results: Decrease of symptoms and improvement of balance function were larger during the first compared with the latter part of the follow-up period. Visual analogue scale ratings for balance problems were higher than those for dizziness. A prediction model was created based on the results of 4 tests in the acute stage: standing on foam with eyes closed, standing on 1 leg with eyes open, visual analogue scale rating of vertigo at rest, and European Quality of Life questionnaire rating of health-related quality of life. The prediction model identified subjects at risk of having remaining symptoms after 6 months with a sensitivity of 86% and a specificity of 79%. Conclusions: Recovery mainly takes place during the first weeks after AUVL. Subjects rate more balance problems than dizziness. Self-rated remaining symptoms after 6 months may be predicted by clinical balance tests and subjective ratings in the acute stage.

  • 28.
    Kammerlind, Ann-Sofi
    et al.
    Linköping University, Department of Department of Health and Society, Division of Physiotherapy. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Skargren, Elisabeth
    Linköping University, Department of Department of Health and Society, Division of Physiotherapy. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Long-term follow-up after acute unilateral vestibular loss and comparison between subjects with and without remaining symptoms2005In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 125, no 9, p. 946-953Article in journal (Refereed)
    Abstract [en]

    Conclusions. About half of the subjects in this study reported remaining symptoms 3–6 years after acute unilateral vestibular loss. Differences could be seen between subjects with and without remaining symptoms regarding health-related quality of life, anxiety and depression.

    Objective. To evaluate the presence of self-rated remaining symptoms 3–6 years after acute unilateral vestibular loss, and to compare subjects with and without such symptoms.

    Material and methods. Firstly, 51 subjects answered a questionnaire which included the EuroQol EQ-5D, the Hospital Anxiety and Depression Scale, the University of California Los Angeles Dizziness Questionnaire, visual analogue scales and the Dizziness Handicap Inventory. Secondly, nine subjects with and nine without remaining symptoms participated in an extended testing procedure, including electronystagmography (ENG), determination of vestibular-evoked myogenic potentials (VEMPs) and clinical balance tests.

    Results. In the first part of the study, 27 subjects reported remaining symptoms, 3 reported 1 additional period of symptoms and 21 had not experienced any symptoms at all in the 3–6 years since acute unilateral vestibular loss. In the second part, the group with remaining symptoms rated a lower health-related quality of life and a higher level of anxiety and depression. There were no differences between the two groups in terms of ENG tests, VEMPs or clinical balance tests.

  • 29.
    Kammerlind, Ann-Sofi
    et al.
    Linköping University, Department of Department of Health and Society, Division of Physiotherapy. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Skargren, Elisabeth
    Linköping University, Department of Department of Health and Society, Division of Physiotherapy. Linköping University, Faculty of Health Sciences.
    Effects of home training and additional physical therapy on recovery after acute unilateral vestibular loss: a randomized study2005In: Clinical Rehabilitation, ISSN 0269-2155, E-ISSN 1477-0873, Vol. 19, no 1, p. 54-62Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate the effects of additional physical therapy on recovery after acute unilateral vestibular loss given to patients receiving home training.

    Design: Randomized controlled trial.

    Setting: Ear, nose and throat departments in three hospitals.

    Subjects: Fifty-four patients (mean age 52 years) with acute unilateral vestibular loss within the last week confirmed with electronystagmography testing were included. Patients with central neurologic or auditory symptoms or other vertigo disease were excluded.

    Interventions: Home training with or without additional physical therapy 12 times during 10 weeks.

    Main measures: Electronystagmography testing was performed before and after the training period. Clinical static (Romberg?s test, sharpened Romberg?s test, standing on foam and standing on one leg) and dynamic (walking forward and backward on a line) balance tests and subjective ratings of vertigo and balance problems on a visual analogue scale were done one week, 10 weeks and six months after the start of training.

    Results: Similar changes were seen in the two training groups.

    Conclusions: No significant differences in outcome regarding balance function or perceived symptoms were found between home training with or without additional physical therapy.

  • 30.
    Kammerlind, Ann-Sofi
    et al.
    Linköping University, Department of Department of Health and Society, Division of Physiotherapy. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Skargren, Elisabeth
    Linköping University, Department of Department of Health and Society, Division of Physiotherapy. Linköping University, Faculty of Health Sciences.
    Influence of asymmetry of vestibular caloric response and age on balance and perceived symptoms after acute unilateral vestibular loss2006In: Clinical Rehabilitation, ISSN 0269-2155, E-ISSN 1477-0873, Vol. 20, no 2, p. 142-148Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate the influence of asymmetry of vestibular caloric response and age on balance and perceived symptoms after acute unilateral vestibular loss.

    Design: Prospective study.

    Setting: Ear, nose and throat departments in three hospitals.

    Subjects: Fifty-four patients (mean age 52 years) with acute unilateral vestibular loss participating in a randomized controlled training study were included.

    Main measures: Electronystagmography testing was performed within one week after onset of symptoms and after 10 weeks. The outcome measures clinical static balance tests (sharpened Romberg's test with eyes closed, standing on foam with eyes closed, and standing on one leg with eyes open and closed) and subjective symptom ratings on a visual analogue scale were done after one week, 10 weeks and six months. The correlation between age and asymmetry of vestibular caloric response, respectively, and the outcome measures were analysed.

    Results: Greater caloric asymmetry correlated with poorer performance at the sharpened Romberg's test and standing on one leg with eyes closed at all three follow-ups (rho=-0.31 to -0.54), and with higher symptom ratings at the 10-week and six-month follow-ups (rho=0.30-0.60). Higher age was associated with poorer performance on the sharpened Romberg's test and standing on one leg at all three follow-ups (rho=0.31-0.64), but did not change over time. Higher age was also associated with higher ratings of vertigo at the six-month follow-up, and less reduction of vertigo between the 10-week and six-month follow-ups (rho=0.29-0.48).

    Conclusions: A higher degree of asymmetry of vestibular caloric response and high age seem to be associated with poor outcome in balance and perceived symptoms after acute unilateral vestibular loss.

  • 31. Kogler, A
    et al.
    Lindfors, J
    Ödkvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Ledin, Torbjörn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Postural control in different neck positions2002In: Neurootol Newslett, ISSN 1023-6422, Vol. 6, p. 25-27Article in journal (Refereed)
  • 32. Kogler, A.
    et al.
    Lindfors, J.
    Ödkvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Ledin, Torbjörn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Postural stability using different neck positions in normal subjects and patients with neck trauma2000In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 120, no 2, p. 151-155Article in journal (Refereed)
    Abstract [en]

    Subjects with neck problems, such as whiplash injuries, often complain of disturbed equilibrium and, in some instances, provocation of the neck position can elicit such problems. The importance of neck proprioceptors for maintaining balance is gaining increased interest, moreover the function or malfunction of the otoliths may disturb equilibrium in certain head positions. The aim of the study was to create a reference material for postural control and its dependence on head position in healthy subjects and to compare this with a set of patients with known neck problems and associated vertiginous problems. A total of 32 healthy subjects (16 men, 16 women, age range 21-58 years) as well as 10 patients age range 27-62 years (mean 44 years) with neck problems and associated balance problems since a whiplash injury were tested for postural control using the EquiTest dynamic posturographic model. The normal subjects were initially split into four age groups in order to estimate the effects of age on performance. The postural stability was evaluated for dependence of support surface conditions (stable or sway-referenced), visual input (eyes open or closed) and head position (neutral, left rotated, right rotated, extended backwards or flexed forward) using analysis of variance (ANOVA) with Tukey's post hoc test in case of a significant factor effect. As expected, visual cues as well as stable support surface improve postural stability (p < 0.001). Postural stability is statistically different in the head extended backwards condition compared with the other four head positions (p < 0.001 in all cases) in both patients and controls. Eliminating this test condition from the analysis, only a slight (p < 0.05) difference between head forwards and head turned left remained. This pattern of results remained if the normal subjects were only split into two age groups instead of four. Finally, the patient group exhibited significantly lower postural performance than all the groups of normal subjects (p < 0.01), but none of the normal groups differed significantly from each other. It is concluded that the postural control system is significantly challenged in the head extended backwards condition in both normal subjects and patients with previous whiplash injury and persistent neck problems. The patient group differed statistically from all groups of normal subjects. This suggests that neck problems impair postural control, and that the head extended position is a more challenging task for the postural system to adapt to. Whether this is due to utricular malpositioning, central integrative functions or cervical proprioceptive afferents is not within the scope of this study to answer. ⌐ 2000 Taylor & Francis.

  • 33.
    Larsby, Birgitta
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    A broad frequency oscillatory test1982In: Nordic symposium on data processing of eye movements, 1982, p. 19-Conference paper (Other academic)
  • 34.
    Larsby, Birgitta
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    A computerized broad spectrum rotatory test1983In: Proc NES 1983, 1983, p. 266-272Conference paper (Other academic)
  • 35.
    Larsby, Birgitta
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Ett bredfrekvent rotationstest1982In: Sv Otolaryngol förening 1982;2, 1982, p. 2-Conference paper (Other academic)
  • 36.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Oto-Rhino-Laryngology, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Department of Oto-Rhino-Laryngology, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Oto-Rhino-Laryngology, Linköping University, Linköping, Sweden.
    Gain and phase characteristics of compensatory eye movements in light and darkness: A study with a broad frequency-band rotatory test1984In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 97, no 3-4, p. 223-232Article in journal (Refereed)
    Abstract [en]

    Thirteen normal subjects were investigated with a broad frequency-band (up to 4.5 Hz) rotatory test. The vestibular stimulation consisted of either a pseudo-random or a sinusoidal frequency sweep oscillation. Eye movements were recorded by EOG. Head movements were recorded either by a potentiometer attached to the chairs axis of rotation or by an angular rate sensor attached to a biteboard. Gain and phase values between eye and head movements were calculated. Measurements were performed in light and darkness during the execution of various fixation tasks. In the higher frequency range there was a difference in gain and phase between potentiometer and rate sensor measurements due to movement of the head relative to the headholder. Visual suppression, in agreement with earlier studies, was more effective during a sinusoidal stimulation than during a pseudorandom stimulation at low frequencies, using the more precise rate sensor measurement technique. Different instructions in the dark could alter the gain values at lower frequencies (up to 2 Hz) during sinusoidal stimulation. During pseudo-random stimulation no such differences could be elicited. Under all test conditions with the rate sensor, the gain values approached unity at about 3 Hz.

  • 37.
    Larsby, Birgitta
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Rotationstest i vestibulär diagnostik1983In: Sv Otolaryngol förening ,1:83, 1983, p. 76-77Conference paper (Other academic)
  • 38.
    Larsby, Birgitta
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Persson, P.
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköping University.
    Caloric and rotatory tests in patients with uni-and bilateral vestibular loss1984In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 97, no 412, p. 111-112Article in journal (Refereed)
  • 39.
    Larsby, Birgitta
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Möller, Claes
    Linköping University.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Smooth pursuit in normals and patients with acoustic neuromas1987In: The Vestibular system: Neurophysiologic and clinical research / [ed] Malcolm D. Graham, John L. Kemink, New York: Raven Press , 1987, p. 293-296Conference paper (Refereed)
  • 40.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Tham, Richard
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Eriksson, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Bunnfors, Irja
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Effects of Trichloroethylene on the human vestibulo-oculomotor system1986In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 101, no 3-4, p. 193-199Article in journal (Refereed)
    Abstract [en]

    Ten healthy volunteers were subjected to a vestibulo-oculomotor test battery before, during and 1 hour after trichloroethylene exposure. The concentration of trichloroethylene in in-spiratory air was 32–78 ppm (176429 mg/m3). The concentration of trichloroethylene in venous blood was followed throughout the experiment. The mean pulmonary uptake was estimated. Each test person was also subjected to a control experiment, breathing air free of trichloroethylene. A decreased ability to visually suppress the vestibulo-oculomotor reflex during sinusoidal stimulation was noticed during trichloroethylene exposure. One hour after exposure the test subjects showed a decreased maximum velocity of the voluntary saccade and a decreased ability to follow a sinusoidally moving target.

     

  • 41.
    Larsby, Birgitta
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Eriksson, Birgitta
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Methods for studying the vestibular and optomotor system in rats1986In: Claussen C-F, Kirtane MV, editors. Vertigo, nausea,tinnitus and hearing loss in cardiovasculr disease.: Elsevier SciencePublishers B.V.; 1986 / [ed] Claussen C-F, Kirtane MV, 1986, p. 265-268Conference paper (Other academic)
  • 42.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Tham, Richard
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Eriksson, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    The effect of toluene on the vestibulo- and opto-oculomotor system in rats: A computerized nystagmographic study1986In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 101, no 5-6, p. 422-428Article in journal (Refereed)
    Abstract [en]

    The short-term effect of exposure to toluene on the vestibulo- and opto-oculomotor system in rats was investigated. Stimulation of the vestibulo- and opto-oculomotor system was either a constant rotatory acceleration, a sinusoidal oscillation, a randomized oscillation or an optokinetic stimulation. Eye movements in response to the different stimulations were recorded by EOG and fed into a computer for analysis. Due to toluene exposure the slow phase velocity gain during constant acceleration increased and the post-acceleratory nystagmus response was prolonged. The optokinetic gain at stimulation velocities above 10 deg/sec decreased during toluene exposure. Toluene also prolonged the duration of optokinetic after-and after-afternystagmus. The findings in this study strongly suggest an effect of toluene on the cerebellum.

     

  • 43.
    Larsby, Birgitta
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Tham, Richard
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Balanspåverkan av industriella lösningsmedel1981In: Nordisk Otolaryngologisk Förenings XXI kongress, Åbo 16.8-19.8 1981, 1981, p. 98-Conference paper (Other academic)
  • 44.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Otolaryngology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Tham, Richard
    Linköping University. Department of Otolaryngology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Influence on the vestibular system by industrial solvents1982In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 93, no s386, p. 246-248Article in journal (Refereed)
  • 45.
    Larsby, Birgitta
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Tham, Richard
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Vestibulo-oculomotor effects of toluene on noulectomized rats1987Conference paper (Other academic)
  • 46.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Bunnfors, Irja
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Exposure of rabbits to styrene. Electronystagmographic findings correlated to the styrene level in blood and cerebrospinal fluid1978In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 4, no 1, p. 60-65Article in journal (Refereed)
    Abstract [en]

    Objective methods for critically evaluating the toxic effect of industrial solvents are highly desirable. As many of these solvents are suspected to cause vertigo, an animal experimental model was set up for studying the effects of solvents on the vestibular systems. The vestibular function was studied by registration of involuntary eye movements--nystagmus--which are elicited via central vestibulo-oculomotor connections. During exposure to styrene a so-called positional nystagmus was demonstrated that indicated vestibular disturbances. Nystagmus is normally elicited by rotatory acceleration. During exposure to styrene the direction of this rotatory nystagmus was reversed. The incidence of the positional nystagmus correlated well with the blood level of the solvent, measured by gas chromatography. Kinetic studies also demonstrated a rapid equilibration between the level of the solvent in arterial blood and cerebrospinal fluid, and therefore suggested that estimation of the arterial level reliably indicates the level in the central nervous system.

  • 47.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Tham, Richard
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Norlander, Björn
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Hydén, Dag
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Aschan, Gunnar
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Rubin, A.
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Exposure of rabbits to methylchloroform. Vestibulardisturbances correlated to blood and cerebrospinal fluid levels1978In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 41, no 1, p. 7-15Article in journal (Refereed)
    Abstract [en]

    A previously described experimental model for studying the effects on the central nervous system of rabbits, specifically the vestibular apparatus, has been applied to methylchloroform. To achieve a steady concentration the solvent was infused as a lipid emulsion. The blood and cerebrospinal fluid kinetics have been studied. The arterial blood level seems to be closely correlated to the concentration in the central nervous tissue. Vestibular function has been studied by recording the involuntary eye movements — nystagmus — which are elicited via central vestibulo-oculomotor connections. At blood levels of methylchloroform above 75 ppm a so called “positional nystagmus”, indicated vestibular disturbances, is demonstrated. The relationship between the present findings in rabbits and the reaction and blood concentrations in people exposed to industrial solvents, are discussed.

  • 48.
    Larsby, Birgitta
    et al.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Change in vestibular-oculomotor function due to transdermally applied scopolamine1985In: In: Myers E, editor.; 1985  Elsevier SiencePublishers B.V., 1985, p. 297-298Conference paper (Other academic)
  • 49.
    Larsby, Birgitta
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Thell, Jan
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Möller, Claes
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    The effect of stimulus predictability and age on human tracking eye movements1988In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 105, p. 21-30Article in journal (Refereed)
    Abstract [en]

    Human tracking eye movements were recorded in healthy volunteers of varying age. The target motion was either predictable (pure sinusoids or sinusoidal frequency sweep) or unpredictable (pseudorandomized). Gain and phase values for the tracking and the smooth pursuit eye movement signal were calculated as a function of target frequency from 0.2 to 2 Hz. Max. target velocity was 20 or 40 deg/sec. In the low frequency area the smooth pursuit gain for predictable stimulation was higher than the gain elicited by the pseudorandomized stimulation. In the high-frequency area, gain values did not differ significantly. For the predictable stimulation, the phase of the smooth component was always a lag, increasing with increasing frequency. At low frequencies of the pseudorandomized signal a phase lead was observed. At higher frequencies the lead turned into a lag that was greater than for the predictable stimulation. The young and old groups showed reduced smooth pursuit gain values, compared with the main group specially when the target waveform was pseudorandomized. The reduced smooth pursuit ability was mostly compensated for by an increased amount of saccades.

  • 50.
    Larsby, Birgitta
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköping University.
    Eriksson, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Optokinetic disturbances caused by styrene. An experimental study in rabbit1995In: NES, 1995;8, 1995, p. 433-441Conference paper (Other academic)
12 1 - 50 of 97
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