liu.seSearch for publications in DiVA
Change search
Refine search result
1 - 12 of 12
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Fick, J.
    et al.
    Department of Chemistry, Umeå University, Umeå, Sweden.
    Lindberg, R.H.
    Department of Chemistry, Umeå University, Umeå, Sweden.
    Tysklind, M.
    Department of Chemistry, Umeå University, Umeå, Sweden.
    Haemig, P.D.
    Section for Zoonotic Ecology and Epidemiology, Kalmar University, Kalmar, Sweden.
    Waldenstrom, J.
    Waldenström, J., Section for Zoonotic Ecology and Epidemiology, Kalmar University, Kalmar, Sweden, Department of Animal Ecology, Lund University, Lund, Sweden.
    Wallensten, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Olsen, B.
    Section for Zoonotic Ecology and Epidemiology, Kalmar University, Kalmar, Sweden, Section of Infectious Diseases, Department of Clinical Sciences, Uppsala University Hospital, Uppsala, Sweden.
    Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: Implications for development of resistance by influenza A virus2007In: PLoS ONE, ISSN 1932-6203, Vol. 2, no 10Article in journal (Refereed)
    Abstract [en]

    Oseltamivir is the main antiviral for treatment and prevention of pandemic influenza. The increase in oseltamivir resistance reported recently has therefore sparked a debate on how to use oseltamivir in non pandemic influenza and the risks associated with wide spread use during a pandemic. Several questions have been asked about the fate of oseltamivir in the sewage treatment plants and in the environment. We have assessed the fate of oseltamivir and discuss the implications of environmental residues of oseltamivir regarding the occurrence of resistance. A series of batch experiments that simulated normal sewage treatment with oseltamivir present was conducted and the UV-spectra of oseltamivir were recorded. Findings. Our experiments show that the active moiety of oseltamivir is not removed in normal sewage water treatments and is not degraded substantially by UV light radiation, and that the active substance is released in waste water leaving the plant. Our conclusion is that a ubiquitous use of oseltamivir may result in selection pressures in the environment that favor development of drug-resistance. © 2007 Fick et al.

  • 2.
    Fouchier, Ron A. M.
    et al.
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Munster, Vincent J.
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Wallensten, Anders
    Smedby Health Care Center, Kalmar.
    Bestebroer, Theo M.
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Herfst, Sander
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Smith, Derek
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Rimmelzwaan, Gus F.
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Olsen, Björn
    Department of Biology and Environmental Science, Kalmar University, Kalmar, Sweden.
    Osterhaus, Albert D. M. E.
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from Black-headed Gulls2005In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 79, no 5, p. 2814-2822Article in journal (Refereed)
    Abstract [en]

    In wild aquatic birds and poultry around the world, influenzaA viruses carrying 15 antigenic subtypes of hemagglutinin (HA)and 9 antigenic subtypes of neuraminidase (NA) have been described.Here we describe a previously unidentified antigenic subtypeof HA (H16), detected in viruses circulating in black-headedgulls in Sweden. In agreement with established criteria forthe definition of antigenic subtypes, hemagglutination inhibitionassays and immunodiffusion assays failed to detect specificreactivity between H16 and the previously described subtypesH1 to H15. Genetically, H16 HA was found to be distantly relatedto H13 HA, a subtype also detected exclusively in shorebirds,and the amino acid composition of the putative receptor-bindingsite of H13 and H16 HAs was found to be distinct from that inHA subtypes circulating in ducks and geese. The H16 virusescontained NA genes that were similar to those of other Eurasianshorebirds but genetically distinct from N3 genes detected inother birds and geographical locations. The European gull viruseswere further distinguishable from other influenza A virusesbased on their PB2, NP, and NS genes. Gaining information onthe full spectrum of avian influenza A viruses and creatingreagents for their detection and identification will remainan important task for influenza surveillance, outbreak control,and animal and public health. We propose that sequence analysesof HA and NA genes of influenza A viruses be used for the rapididentification of existing and novel HA and NA subtypes.

  • 3.
    Karlsson, M.
    et al.
    Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden.
    Wallensten, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Lundkvist, A.
    Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden, Microbiology and Tumor Biology Center, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Olsen, B.
    Section of Infectious Diseases, Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden, Department of Biology and Environmental Science, University of Kalmar, SE-391 82 Kalmar, Sweden.
    Brytting, M.
    Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden.
    A real-time PCR assay for the monitoring of influenza a virus in wild birds2007In: Journal of Virological Methods, ISSN 0166-0934, E-ISSN 1879-0984, Vol. 144, no 1-2, p. 27-31Article in journal (Refereed)
    Abstract [en]

    A screening system including a new real-time PCR assay for the monitoring of influenza A virus in wild birds was developed. The real-time PCR assay uses SYBR green chemistry and the primers are targeting the matrix gene of influenza A virus. The performance of the assay was compared with two other assays, one assay also using SYBR green chemistry and one assay using TaqMan chemistry, i.e. a specific probe. A total of 45 fecal bird samples were analysed for influenza A virus in three different PCR reactions. Overall, 26 samples were positive in at least one of the three real-time PCR assays. Of the 26 samples, 18 were positive by all three reactions. Eight samples were found positive exclusively by the two SYBR green reactions, six of which were detected by both SYBR green reactions. Of the 26 positive samples, 15 samples were verified as positive either by virus isolation or influenza A M2-gene PCR. The results showed that the two SYBR green systems had a higher performance regarding the detection of influenza A as compared to the PCR reaction using a specific probe. © 2007 Elsevier B.V. All rights reserved.

  • 4.
    Munster, Vincent J.
    et al.
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Wallensten, Anders
    Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology . Linköping University, Faculty of Health Sciences.
    Baas, Chantal
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Rimmelzwaan, Guus F.
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Schutten, Martin
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Olsen, Björn
    Umea University, Umea, Sweden.
    Osterhaus, Albert D.M.E
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Fouchier, Ron A.M
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe2005In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 11, no 10, p. 1545-1551Article in journal (Refereed)
    Abstract [en]

    Outbreaks of highly pathogenic avian influenza (HPAI), which originate in poultry upon transmission of low pathogenic viruses from wild birds, have occurred relatively frequently in the last decade. During our ongoing surveillance studies in wild birds, we isolated several influenza A viruses of hemagglutinin subtype H5 and H7 that contain various neuraminidase subtypes. For each of the recorded H5 and H7 HPAI outbreaks in Europe since 1997, our collection contained closely related virus isolates recovered from wild birds, as determined by sequencing and phylogenetic analyses of the hemagglutinin gene and antigenic characterization of the hemagglutinin glycoprotein. The minor genetic and antigenic diversity between the viruses recovered from wild birds and those causing HPAI outbreaks indicates that influenza A virus surveillance studies in wild birds can help generate prototypic vaccine candidates and design and evaluate diagnostic tests, before outbreaks occur in animals and humans.

  • 5.
    Munster, V.J.
    et al.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Baas, C.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Lexmond, P.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Waldenstrom, J.
    Waldenström, J., Section for Zoonotic Ecology and Epidemiology, Department of Biology and Environmental Science, University of Kalmar, Kalmar, Sweden.
    Wallensten, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Fransson, T.
    Bird Ringing Center, Swedish Museum of Natural History, Stockholm, Sweden.
    Rimmelzwaan, G.F.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Beyer, W.E.P.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Schutten, M.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Olsen, B.
    Section for Zoonotic Ecology and Epidemiology, Department of Biology and Environmental Science, University of Kalmar, Kalmar, Sweden, Department of Clinical Science, Uppsala University Hospital, Uppsala, Sweden.
    Osterhaus, A.D.M.E.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Fouchier, R.A.M.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands.
    Spatial, temporal, and species variation in prevalence of influenza a viruses in wild migratory birds2007In: PLoS Pathogens, ISSN 1553-7366, Vol. 3, no 5, p. 0630-0638Article in journal (Refereed)
    Abstract [en]

    Although extensive data exist on avian influenza in wild birds in North America, limited information is available from elsewhere, including Europe. Here, molecular diagnostic tools were employed for high-throughput surveillance of migratory birds, as an alternative to classical labor-intensive methods of virus isolation in eggs. This study included 36,809 samples from 323 bird species belonging to 18 orders, of which only 25 species of three orders were positive for influenza A virus. Information on species, locations, and timing is provided for all samples tested. Seven previously unknown host species for avian influenza virus were identified: barnacle goose, bean goose, brent goose, pink-footed goose, bewick's swan, common gull, and guillemot. Dabbling ducks were more frequently infected than other ducks and Anseriformes, this distinction was probably related to bird behavior rather than population sizes. Waders did not appear to play a role in the epidemiology of avian influenza in Europe, in contrast to the Americas. The high virus prevalence in ducks in Europe in spring as compared with North America could explain the differences in virus-host ecology between these continents. Most influenza A virus subtypes were detected in ducks, but H13 and H16 subtypes were detected primarily in gulls. Viruses of subtype H6 were more promiscuous in host range than other subtypes. Temporal and spatial variation in influenza virus prevalence in wild birds was observed, with influenza A virus prevalence varying by sampling location, this is probably related to migration patterns from northeast to southwest and a higher prevalence farther north along the flyways. We discuss the ecology and epidemiology of avian influenza A virus in wild birds in relation to host ecology and compare our results with published studies. These data are useful for designing new surveillance programs and are particularly relevant due to increased interest in avian influenza in wild birds. © 2007 Munster et al.

  • 6.
    Olsen, Björn
    et al.
    Department of Infectious Diseases, Umeå University, Umeå, Sweden.
    Munster, Vincent J.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands..
    Wallensten, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Waldenström, Jonas
    Department of Animal Ecology, Lund University, Lund, Sweden..
    Osterhaus, Albert D. M. E.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands..
    Fouchier, Ron A.M.
    Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands..
    Global patterns of influenza A virus in wild birds2006In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 312, no 5772, p. 384-388Article in journal (Refereed)
    Abstract [en]

    The outbreak of highly pathogenic avian influenza of the H5N1 subtype in Asia, which has subsequently spread to Russia, the Middle East, Europe, and Africa, has put increased focus on the role of wild birds in the persistence of influenza viruses. The ecology, epidemiology, genetics, and evolution of pathogens cannot be fully understood without taking into account the ecology of their hosts. Here, we review our current knowledge on global patterns of influenza virus infections in wild birds, discuss these patterns in the context of host ecology and in particular birds' behavior, and identify some important gaps in our current knowledge.

  • 7.
    Wallensten, Anders
    Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology . Linköping University, Faculty of Health Sciences.
    Influenza A virus in wild birds2006Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Influenza virus is a RNA virus that exists as different types and subtypes. Influenza A virus strains are known to cause disease in several bird and mammalian species. Wild birds are believed to constitute the natural reservoir for influenza A virus.

    In humans, influenza A virus causes yearly seasonal influenza epidemics of respiratory disease resulting in high morbidity and severe economic consequences. Due to the virus’ ability to change its antigenic properties by mutation, yearly vaccination is required for protection from the disease.

    There are many different subtypes of influenza virus which are characterized according to two surface structures - the hemagglutinin and neuraminidase proteins - , for example; H5N1. These subtypes have the ability to recombine, and thereby creating new variant combinations. If a subtype that the living population of humans has not encountered before starts to spread among humans, it can result in a pandemic. Pandemic outbreaks have occurred at irregular intervals throughout history and have had a devastating impact on mankind. For example the Spanish influenza pandemic of 1918 is thought to have killed more than 50 million people.

    Influenza A virus is also an important cause of disease in poultry where virus strains of some subtypes may change into forms that are highly pathogenic. These virus strains may transmit directly to man and multiple other species. This has been the case in the ongoing outbreak that started in South East Asia in 2003. All known subtypes of influenza A virus have been isolated from wild birds living in aquatic environments, mainly dabbling ducks. These species are considered to be the reservoir for influenza A virus. The virus causes sub clinical gastrointestinal infection in ducks. High amounts of virus are excreted in the feces and spread via the fecal-oral route through water where it can persist for a prolonged time.

    There are still many unknowns about the ecology of influenza virus in the wild bird reservoir. This thesis includes five articles where data are presented that add new knowledge on this subject. We add proof that wild ducks are indeed the host for most influenza A virus subtypes by presenting data from a meta-analysis on all published screening data from wild birds and by presenting data from a four year screening of migratory ducks that were caught and sampled at Ottenby Bird Observatory. Our investigations have shown that the prevalence of influenza virus in the wild duck population of western Eurasia shows temporal differences in comparison to the results found in studies in North America. The prevalence in western Eurasian ducks is high during the period August to December and also rises in the spring. These findings are of importance for the understanding of how influenza virus is perpetuated in nature. During the course of the study only low pathogenic subtypes were isolated. Of concern is the high frequency of isolation of virus strains of the H5 and H7 subtypes that are prone to change into highly pathogenic variants in poultry. Many of the strains isolated in our study are similar to the ones that have caused influenza outbreaks in poultry in Europe during the last seven years. This indicates that wild bird surveillance for influenza A virus can be of major value as a sentinel system to prevent outbreaks in domestic poultry.

    Studies on Black-headed Gulls (Larus ridibundus) revealed a previously unknown subtype, H16. This finding widened the spectra of known influenza A virus subtypes in nature.

    Influenza A virus was also isolated in samples from Guillemots (Uria aalge) in the Baltic Sea. This was the first time influenza A virus was isolated from this species in Europe. The isolated virus strains contained a mix of genes, some of which must have been derived from influenza A virus strains present in the North American bird population. This finding proves that limited exchanges between the virus strains present on the American and the Eurasian continents exist, which is of concern for evaluating the risk of spread of highly pathogenic virus strains by wild birds to the Americas.

    List of papers
    1. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from Black-headed Gulls
    Open this publication in new window or tab >>Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from Black-headed Gulls
    Show others...
    2005 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 79, no 5, p. 2814-2822Article in journal (Refereed) Published
    Abstract [en]

    In wild aquatic birds and poultry around the world, influenzaA viruses carrying 15 antigenic subtypes of hemagglutinin (HA)and 9 antigenic subtypes of neuraminidase (NA) have been described.Here we describe a previously unidentified antigenic subtypeof HA (H16), detected in viruses circulating in black-headedgulls in Sweden. In agreement with established criteria forthe definition of antigenic subtypes, hemagglutination inhibitionassays and immunodiffusion assays failed to detect specificreactivity between H16 and the previously described subtypesH1 to H15. Genetically, H16 HA was found to be distantly relatedto H13 HA, a subtype also detected exclusively in shorebirds,and the amino acid composition of the putative receptor-bindingsite of H13 and H16 HAs was found to be distinct from that inHA subtypes circulating in ducks and geese. The H16 virusescontained NA genes that were similar to those of other Eurasianshorebirds but genetically distinct from N3 genes detected inother birds and geographical locations. The European gull viruseswere further distinguishable from other influenza A virusesbased on their PB2, NP, and NS genes. Gaining information onthe full spectrum of avian influenza A viruses and creatingreagents for their detection and identification will remainan important task for influenza surveillance, outbreak control,and animal and public health. We propose that sequence analysesof HA and NA genes of influenza A viruses be used for the rapididentification of existing and novel HA and NA subtypes.

    Place, publisher, year, edition, pages
    ASM International, 2005
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14099 (URN)10.1128/JVI.79.5.2814-2822.2005 (DOI)
    Available from: 2006-10-27 Created: 2006-10-27 Last updated: 2017-12-13Bibliographically approved
    2. Multiple gene segment reassortment between Eurasian and American lineages of influenza A virus (H6N2 in Guillemot (Uria aalge)
    Open this publication in new window or tab >>Multiple gene segment reassortment between Eurasian and American lineages of influenza A virus (H6N2 in Guillemot (Uria aalge)
    Show others...
    2005 (English)In: Archives of Virology, ISSN 0304-8608, Vol. 150, no 8, p. 1685-1692Article in journal (Refereed) Published
    Abstract [en]

    Guillemots banded in the northern Baltic Sea were screened for influenza A virus (IAV). Three out of 26 sampled birds tested positive by RT-PCR. Two of these were characterized as subtype H6N2. Phylogenetic analyses showed that five gene segments belonged to the American avian lineage of IAVs, whereas three gene segments belonged to the Eurasian lineage. Our findings indicate that avian IAVs may have a taxonomically wider reservoir spectrum than previously known and we present the first report of a chimeric avian IAV with genes of American and Eurasian origin in Europe.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14100 (URN)10.1007/s00705-005-0543-8 (DOI)
    Available from: 2006-10-27 Created: 2006-10-27
    3. Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe
    Open this publication in new window or tab >>Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe
    Show others...
    2005 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 11, no 10, p. 1545-1551Article in journal (Refereed) Published
    Abstract [en]

    Outbreaks of highly pathogenic avian influenza (HPAI), which originate in poultry upon transmission of low pathogenic viruses from wild birds, have occurred relatively frequently in the last decade. During our ongoing surveillance studies in wild birds, we isolated several influenza A viruses of hemagglutinin subtype H5 and H7 that contain various neuraminidase subtypes. For each of the recorded H5 and H7 HPAI outbreaks in Europe since 1997, our collection contained closely related virus isolates recovered from wild birds, as determined by sequencing and phylogenetic analyses of the hemagglutinin gene and antigenic characterization of the hemagglutinin glycoprotein. The minor genetic and antigenic diversity between the viruses recovered from wild birds and those causing HPAI outbreaks indicates that influenza A virus surveillance studies in wild birds can help generate prototypic vaccine candidates and design and evaluate diagnostic tests, before outbreaks occur in animals and humans.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14101 (URN)
    Available from: 2006-10-27 Created: 2006-10-27 Last updated: 2017-12-13
    4. Surveillance of Influenza A Virus in Migratory Waterfowl in Northern Europe
    Open this publication in new window or tab >>Surveillance of Influenza A Virus in Migratory Waterfowl in Northern Europe
    Show others...
    2007 (English)In: Emerging Infectious Diseases, Vol. 13, no 3, p. 404-411Article in journal (Refereed) Published
    Abstract [en]

    We conducted large-scale, systematic sampling of influenza type A virus in migratory waterfowl (mostly mallards [Anas platyrhynchos]) at Ottenby Bird Observatory, southeast Sweden. As with previous studies, we found a higher prevalence in fall than spring, and among juveniles compared with adults. However, in contrast to other studies, we found that prevalence in spring was sometimes high (mean 4.0%, highest 9.5%). This finding raises the possibility that ducks are capable of perpetuating influenza A virus of different subtypes and subtype combinations throughout the year and from 1 year to the next. Isolation of the H5 and H7 subtypes was common, which suggests risk for transmission to sensitive domestic animals such as poultry. We argue that wild bird screening can function as a sentinel system, and we give an example of how it could have been used to forecast a remote and deadly outbreak of influenza A in poultry.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14102 (URN)
    Available from: 2006-10-27 Created: 2006-10-27
    5. Global patterns of influenza A virus in wild birds
    Open this publication in new window or tab >>Global patterns of influenza A virus in wild birds
    Show others...
    2006 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 312, no 5772, p. 384-388Article in journal (Refereed) Published
    Abstract [en]

    The outbreak of highly pathogenic avian influenza of the H5N1 subtype in Asia, which has subsequently spread to Russia, the Middle East, Europe, and Africa, has put increased focus on the role of wild birds in the persistence of influenza viruses. The ecology, epidemiology, genetics, and evolution of pathogens cannot be fully understood without taking into account the ecology of their hosts. Here, we review our current knowledge on global patterns of influenza virus infections in wild birds, discuss these patterns in the context of host ecology and in particular birds' behavior, and identify some important gaps in our current knowledge.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14103 (URN)10.1126/science.1122438 (DOI)
    Available from: 2006-10-27 Created: 2006-10-27 Last updated: 2017-12-13
  • 8.
    Wallensten, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Influenza virus in wild birds and mammals other than man2007In: Microbiological Ecology in Health and Disease, ISSN 0891-060X, E-ISSN 1651-2235, Vol. 19, no 2, p. 122-139Article, review/survey (Refereed)
    Abstract [en]

    Influenza virus is an RNA virus that exists as different types and subtypes. Influenza A virus strains are known to cause disease in several bird and mammalian species. Wild birds are believed to constitute the natural reservoir for influenza A virus. Influenza A virus has the ability to change through antigenic drift and recombination allowing for the emergence of new strains and subtype combinations. In man influenza A virus causes yearly seasonal epidemics and, at irregular intervals, pandemic outbreaks have had a devastating impact on mankind. For example, the Spanish influenza pandemic of 1918 is thought to have killed more than 50 million people. Influenza A virus is an important cause of disease in poultry, where virus strains of the H5 and H7 subtypes may change into forms that are highly pathogenic. These virus strains may transmit directly to man and multiple other species. This has been the case in the ongoing outbreak that started in South-east Asia in 2003. All known subtypes of influenza A virus have been isolated from wild birds living in aquatic environments, mainly dabbling ducks. This review focuses on what is known about the pathogenicity and spread of influenza A virus in species other than man, with particular emphasis on the wild bird reservoir. © 2007 Taylor & Francis.

  • 9.
    Wallensten, Anders
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology . Linköping University, Faculty of Health Sciences.
    Munster, Vincent J.
    Department of Virology and National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands.
    Elmberg, Johan
    Department of Mathematics and Natural Sciences, Kristianstad University, Kristianstad, Sweden.
    Osterhaus, Albert D. M. E.
    Department of Virology and National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands.
    Fouchier, Ron A. M.
    Department of Virology and National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands.
    Olsen, Björn
    Department of Infectious Diseases, Umeå University, Umeå, Sweden.
    Multiple gene segment reassortment between Eurasian and American lineages of influenza A virus (H6N2 in Guillemot (Uria aalge)2005In: Archives of Virology, ISSN 0304-8608, Vol. 150, no 8, p. 1685-1692Article in journal (Refereed)
    Abstract [en]

    Guillemots banded in the northern Baltic Sea were screened for influenza A virus (IAV). Three out of 26 sampled birds tested positive by RT-PCR. Two of these were characterized as subtype H6N2. Phylogenetic analyses showed that five gene segments belonged to the American avian lineage of IAVs, whereas three gene segments belonged to the Eurasian lineage. Our findings indicate that avian IAVs may have a taxonomically wider reservoir spectrum than previously known and we present the first report of a chimeric avian IAV with genes of American and Eurasian origin in Europe.

  • 10.
    Wallensten, Anders
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology . Linköping University, Faculty of Health Sciences.
    Munster, Vincent J.
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Fransson, Thord
    Swedish Museum of Natural History, Stockholm, Sweden.
    Haemig, Paul D.
    Kalmar University, Kalmar, Sweden.
    Karlsson, Malin
    Swedish Institute for Infectious Disease Control, Solna, Sweden.
    Lundkvist, Åke
    Swedish Institute for Infectious Disease Control, Solna, Sweden.
    Osterhaus, Albert D. M. E.
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Stervander, Martin
    Ottenby Bird Observatory, Degerhamn, Sweden.
    Waldenström, Jonas
    Lund University, Lund, Sweden.
    Olsen, Björn
    Umeå University, Umeå, Sweden.
    Latorre-Margalef, Neus
    Kalmar University, Kalmar, Sweden.
    Brytting, Mia
    Swedish Institute for Infectious Disease Control, Solna, Sweden.
    Elmberg, Johan
    Kristianstad University, Kristianstad, Sweden.
    Fouchier, Ron A. M.
    Erasmus Medical Center, Rotterdam, the Netherlands.
    Surveillance of Influenza A Virus in Migratory Waterfowl in Northern Europe2007In: Emerging Infectious Diseases, Vol. 13, no 3, p. 404-411Article in journal (Refereed)
    Abstract [en]

    We conducted large-scale, systematic sampling of influenza type A virus in migratory waterfowl (mostly mallards [Anas platyrhynchos]) at Ottenby Bird Observatory, southeast Sweden. As with previous studies, we found a higher prevalence in fall than spring, and among juveniles compared with adults. However, in contrast to other studies, we found that prevalence in spring was sometimes high (mean 4.0%, highest 9.5%). This finding raises the possibility that ducks are capable of perpetuating influenza A virus of different subtypes and subtype combinations throughout the year and from 1 year to the next. Isolation of the H5 and H7 subtypes was common, which suggests risk for transmission to sensitive domestic animals such as poultry. We argue that wild bird screening can function as a sentinel system, and we give an example of how it could have been used to forecast a remote and deadly outbreak of influenza A in poultry.

  • 11.
    Wallensten, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Munster, V.J.
    Department of Virology, National Influenza Center, Erasmus Medical Center, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, Netherlands.
    Karlsson, M.
    Centre for Microbiological Preparedness (KCB), Swedish Institute for Infectious Disease Control (SMI), SE-171 82 Solna, Sweden.
    Lundkvist, A.
    Centre for Microbiological Preparedness (KCB), Swedish Institute for Infectious Disease Control (SMI), SE-171 82 Solna, Sweden.
    Brytting, M.
    Department of Virology, Swedish Institute for Infectious Disease Control (SMI), SE-171 82 Solna, Sweden.
    Stervander, M.
    Ottenby Bird Observatory, P.O. Box 1500, SE-380 65 Degerhamn, Sweden.
    Osterhaus, A.D.M.E.
    Department of Virology, National Influenza Center, Erasmus Medical Center, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, Netherlands.
    Fouchier, R.A.M.
    Department of Virology, National Influenza Center, Erasmus Medical Center, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, Netherlands.
    Olsen, B.
    Department of Infectious Diseases, Umeå University, SE-901 87 Umeå, Sweden, Department of Biology and Environmental Science, Section for Zoonotic Ecology and Epidemiology, Kalmar University, SE-391 82 Kalmar, Sweden.
    High prevalence of influenza A virus in ducks caught during spring migration through Sweden2006In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 24, no 44-46, p. 6734-6735Article in journal (Refereed)
    Abstract [en]

    As part of our ongoing screening of wild birds in Northern Europe, 358 mallards (Anas platyrhynchos) and 203 shelducks (Tadorna tadorna) were caught in southern Sweden during the spring 2003. Faecal samples were analyzed by real time RT-PCR for the presence of influenza A virus. In contrast to what has been found in North American studies, Eurasian spring migrating ducks passing through Sweden had a relatively high prevalence of influenza A virus. © 2006 Elsevier Ltd. All rights reserved.

  • 12.
    Wallensten, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
    Munster, V.J.
    Department of Virology, National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, Netherlands.
    Osterhaus, A.D.M.E.
    Department of Virology, National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, Netherlands.
    Waldenstrom, J.
    Waldenström, J., Department of Animal Ecology, Ecology Building, Lund University, SE-223 62 Lund, Sweden, Department of Biology and Environmental Science, Section for Zoonotic Ecology and Epidemiology, Kalmar University, SE-391 82 Kalmar, Sweden.
    Bonnedahl, J.
    Department of Infectious Diseases, Umeå University, SE-901 87 Umeå, Sweden.
    Broman, T.
    Department of NBC Analysis, Swedish Defence Research Agency, NBC Defence, SE-901 82 Umeå, Sweden.
    Fouchier, R.A.M.
    Department of Virology, National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, Netherlands.
    Olsen, B.
    Department of Infectious Diseases, Umeå University, SE-901 87 Umeå, Sweden, Department of Biology and Environmental Science, Section for Zoonotic Ecology and Epidemiology, Kalmar University, SE-391 82 Kalmar, Sweden.
    Mounting evidence for the presence of influenza A virus in the avifauna of the Antarctic region2006In: Antarctic Science, ISSN 0954-1020, E-ISSN 1365-2079, Vol. 18, no 3, p. 353-356Article in journal (Refereed)
    Abstract [en]

    Penguin blood samples collected at Bird Island, sub-Antarctic South Georgia, and faecal samples taken from penguins at several localities along the Antarctic Peninsula were analysed in order to investigate if influenza A virus is present in penguin populations in the South Atlantic Antarctic region. Serology was performed on the blood samples while the faecal samples were screened by a RT-PCR method directed at the matrix protein gene for determining the presence of influenza A virus. All faecal samples were negative by PCR, but the blood samples gave serologic indications that influenza A virus is present amongst these penguin species, confirming previous studies, although the virus has still not been isolated from any bird in the Antarctic region. © Antarctic Science Ltd.

1 - 12 of 12
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf