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  • 1.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Biologisk nivå2021Inngår i: Att leva som andra: biopsykosociala perspektiv på funktionsnedsättning och funktionshinder / [ed] Lisa Kilman, Josefine Andin, Håkan Hua, Jerker Rönnberg, Lund: Studentlitteratur AB, 2021, s. 39-66Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 2. Bestill onlineKjøp publikasjonen >>
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Dealing with Digits: Arithmetic, Memory and Phonology in Deaf Signers2014Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Deafness has been associated with poor abilities to deal with digits in the context of arithmetic and memory, and language modality-specific differences in the phonological similarity of digits have been shown to influence short-term memory (STM). Therefore, the overall aim of the present thesis was to find out whether language modality-specific differences in phonological processing between sign and speech can explain why deaf signers perform at lower levels than hearing peers when dealing with digits. To explore this aim, the role of phonological processing in digit-based arithmetic and memory tasks was investigated, using both behavioural and neuroimaging methods, in adult deaf signers and hearing non-signers, carefully matched on age, sex, education and non-verbal intelligence. To make task demands as equal as possible for both groups, and to control for material effects, arithmetic, phonological processing, STM and working memory (WM) were all assessed using the same presentation and response mode for both groups. The results suggested that in digit-based STM, phonological similarity of manual numerals causes deaf signers to perform more poorly than hearing non-signers. However, for  digit-based WM there was no difference between the groups, possibly due to differences in allocation of resources during WM. This indicates that similar WM for the two groups can be generalized from lexical items to digits. Further, we found that in the present work deaf signers performed better than expected and on a par with hearing peers on all arithmetic tasks, except for multiplication, possibly because the groups studied here were very carefully matched. However, the neural networks recruited for arithmetic and phonology differed between groups. During multiplication tasks, deaf signers showed an increased  reliance on cortex of the right parietal lobe complemented by the left inferior frontal gyrus. In contrast, hearing non-signers relied on cortex of the left frontal and parietal lobes during multiplication. This suggests that while hearing non-signers recruit phonology-dependent arithmetic fact retrieval processes for multiplication, deaf signers recruit non-verbal magnitude manipulation processes. For phonology, the hearing non-signers engaged left lateralized frontal and parietal areas within the classical perisylvian language network. In deaf signers, however, phonological processing was limited to cortex of the left occipital lobe, suggesting that sign-based phonological processing does not necessarily activate the classical language network. In conclusion, the findings of the present thesis suggest that language modality-specific differences between sign and speech in different ways can explain why deaf signers perform at lower levels than hearing non-signers on tasks that include dealing with digits.

    Delarbeid
    1. Similar digit-based working memory in deaf signers and hearing non-signers despite digit span differences
    Åpne denne publikasjonen i ny fane eller vindu >>Similar digit-based working memory in deaf signers and hearing non-signers despite digit span differences
    Vise andre…
    2013 (engelsk)Inngår i: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 4, nr 942Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Similar working memory (WM) for lexical items has been demonstrated for signers and non-signers while short-term memory (STM) is regularly poorer in deaf than hearing individuals. In the present study, we investigated digit-based WM and STM in Swedish and British deaf signers and hearing non-signers. To maintain good experimental control we used printed stimuli throughout and held response mode constant across groups. We showed that deaf signers have similar digit-based WM performance, despite shorter digit spans, compared to well-matched hearing non-signers. We found no difference between signers and non-signers on STM span for letters chosen to minimize phonological similarity or in the effects of recall direction. This set of findings indicates that similar WM for signers and non-signers can be generalized from lexical items to digits and suggests that poorer STM in deaf signers compared to hearing non-signers may be due to differences in phonological similarity across the language modalities of sign and speech.

    Emneord
    deaf signers, working memory, short term memory, phonological similarity, Cross-cultural
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-102262 (URN)10.3389/fpsyg.2013.00942 (DOI)000331572800002 ()
    Forskningsfinansiär
    Swedish Research Council, 20051353Forte, Swedish Research Council for Health, Working Life and Welfare, 2008-0846Riksbankens Jubileumsfond, P2008-0481:1-E
    Tilgjengelig fra: 2013-12-04 Laget: 2013-12-04 Sist oppdatert: 2023-12-28bibliografisk kontrollert
    2. Deaf signers use phonology to do arithmetic
    Åpne denne publikasjonen i ny fane eller vindu >>Deaf signers use phonology to do arithmetic
    2014 (engelsk)Inngår i: Learning and individual differences, ISSN 1041-6080, E-ISSN 1873-3425, Vol. 32, s. 246-253Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Deaf students generally lag several years behind hearing peers in arithmetic, but little is known about the mechanisms behind this. In the present study we investigated how phonological skills interact with arithmetic. Eighteen deaf signers and eighteen hearing non-signers took part in an experiment that manipulated arithmetic and phonological knowledge in the language modalities of sign and speech. Independent tests of alphabetical and native language phonological skills were also administered. There was no difference in performance between groups on subtraction, but hearing non-signers performed better than deaf signers on multiplication. For the deaf signers but not the hearing non-signers, multiplicative reasoning was associated with both alphabetical and phonological skills. This indicates that deaf signing adults rely on language processes to solve multiplication tasks, possibly because automatization of multiplication is less well established in deaf adults.

    sted, utgiver, år, opplag, sider
    Elsevier, 2014
    Emneord
    Deaf signers; Arithmetic; Phonology
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-108812 (URN)10.1016/j.lindif.2014.03.015 (DOI)000336820400028 ()
    Tilgjengelig fra: 2014-07-07 Laget: 2014-07-06 Sist oppdatert: 2023-12-28
    3. Phonology and arithmetic in the language-calculation network
    Åpne denne publikasjonen i ny fane eller vindu >>Phonology and arithmetic in the language-calculation network
    2015 (engelsk)Inngår i: Brain and Language, ISSN 0093-934X, E-ISSN 1090-2155, Vol. 143, s. 97-105Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Arithmetic and language processing involve similar neural networks, but the relative engagement remains unclear. In the present study we used fMRI to compare activation for phonological, multiplication and subtraction tasks, keeping the stimulus material constant, within a predefined language-calculation network including left inferior frontal gyrus and angular gyrus (AG) as well as superior parietal lobule and the intraparietal sulcus bilaterally. Results revealed a generally left lateralized activation pattern within the language-calculation network for phonology and a bilateral activation pattern for arithmetic, and suggested regional differences between tasks. In particular, we found a more prominent role for phonology than arithmetic in pars opercularis of the left inferior frontal gyrus but domain generality in pars triangularis. Parietal activation patterns demonstrated greater engagement of the visual and quantity systems for calculation than language. This set of findings supports the notion of a common, but regionally differentiated, language-calculation network. (C) 2015 The Authors. Published by Elsevier Inc.

    sted, utgiver, år, opplag, sider
    Elsevier, 2015
    Emneord
    Phonology; Arithmetic; Brain imaging; Perisylvian language network
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-117794 (URN)10.1016/j.bandl.2015.02.004 (DOI)000352659600010 ()25797099 (PubMedID)
    Merknad

    Funding Agencies|Swedish Research Council [2005-1353].

    The previous status of this article was Manuscript and the working title was Phonological but not arithmetic processing engages left posterior inferior frontal gyrus.

    Tilgjengelig fra: 2015-05-11 Laget: 2015-05-08 Sist oppdatert: 2023-12-28bibliografisk kontrollert
    4. Deaf signers use magnitude manipulatioin strategies for mulitplication: fMRI evidence
    Åpne denne publikasjonen i ny fane eller vindu >>Deaf signers use magnitude manipulatioin strategies for mulitplication: fMRI evidence
    Vise andre…
    2014 (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Evidence suggests that the lag reported in mathematics for deaf signers derives from difficulties related to the verbal system of number processing as described in the triple code model. For hearing individuals the verbal system has been shown to be recruited for both arithmetic and language tasks. In the present study we investigate for the first time neuronal representations of arithmetic in deaf signers. We examine if the neural network supporting arithmetic and language, including the horizontal portion of the intraparietal sulcus (HIPS), the superior parietal lobule (SPL) bilaterally, the left angular gyrus (AG), pars opercularis (POPE) and pars triangularis (PTRI) of the left inferior frontal gyrus (IFG), is differently recruited for deaf and hearing individuals. Imaging data were collected from 16 deaf signers and 16 well-matched hearing nonsigners, using the same stimulus material for all tasks, but with different cues. During multiplication, deaf signers recruited rHIPS more than hearing non-signers, suggesting greater involvement of magnitude manipulation processes related to the quantity system, whereas there was no evidence that the verbal system was recruited. Further, there was no support for the notion of a common representation of phonology for sign and speech as previously suggested.

    Emneord
    Arithmetic; phonology; fMRI; deaf; sign language; magnitude manipulation
    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-111560 (URN)
    Tilgjengelig fra: 2014-10-24 Laget: 2014-10-24 Sist oppdatert: 2023-12-28bibliografisk kontrollert
    Fulltekst (pdf)
    Dealing with Digits: Arithmetic, Memory and Phonology in Deaf Signers
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  • 3.
    Andin, Josefine
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Pharmacological and environmental modulations of the rat glutamatergic system2006Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Glutamate is the principal excitatory neurotransmitter in the central nervous system and it is implicated in neural transmission, learning, memory processes and neuronal plasticity. In the glutamatergic synapse two main components are present; the glutamate receptors and the glutamate transporters. The receptors, the NMDA, AMPA, kainite and the metabotroptic receptors, are responsible for conveying neural transmission, including long term potentiation (LTP), synaptic strengthening and modification. The transporters, located to the neuronal membrane and to the membranes of surrounding astrocytes, regulates the extracellular concentration of glutamate and thereby the duration of the synaptic signal.

    Alterations in both receptor and transporter systems have been suggested to be important in the pathogenesis of several acute and chronic nervous system diseases, such as psychosis, mood disorders, epilepsy, Parkinson's disease and Alzheimer's disease. The pathophysiology of these disorders is not yet completely understood and the involvement of glutamate is unclear. In this thesis we have sought to investigate the role of the glutamatergic system in the treatment of mood disorders and dementia. The antidepressant drug amitriptyline exerts its main effects on the serotonergic and noradrenergic systems and the antidementia drug rivastigmine acts mainly on the cholinergic system. However, given the close relationship between different neurotransmitter systems we have investigated the influence of amitriptyline and rivastigmine on the mRNA expression of the neuronal transporter, EAAC1, in rats. The results showed for the first time an involvement of EAAC1 in amitriptyline and rivastigmine treatment. Amitriptyline induced an acute increase in EAAC1 mRNA expression, which 24 hour after administration returned to baseline levels. Chronic treatment, on the other hand, induces a significant decrease in cortical areas, which we suggest results in enhanced neuronal transmission. Rivastigmine treatment, acute as well as chronic, induced increases in the mRNA expression in hippocampus. We hypothesize that this counteracts the excitotoxic glutamate levels seen in Alzheimer's disease.

    Further, environmental enrichment has been shown to have beneficial effects on capillary supply, the number of glial cells and dendritic spines, the thickness and weight of cortex, the concentration of cholinesterase, LTP and synaptic strength in animals. It has also been reported that humans that lead an active life have a reduced risk of developing Alzheimer's disease. This suggests that an active and stimulated life may have a protective effect against dementia in man, by creating a cognitive reserve which provides a buffer against brain pathology or age-related changes. We investigated the influence of environmental enrichment on the mRNA expression of NMDA and AMPA receptors and on EAACl and showed for the first time that EAAC1 mRNA is decreased after environmental enrichment. This is probably followed by an increase of glutamate in the synapse, which in turn leads to enhanced neuronal transmission including enhanced memory formation and learning. Furthermore, we confirmed in greater detail previous findings on the upregulation of NMDA mRNA and show that the regulation is regionally and hemisphere specific. We also confirm that AMPA mRNA is not per se changed by environmental enrichment in adult animals.

    This work provides further evidence about the involvement of the glutamatergic system in affective and cognitive disorders. Improved knowledge of the glutamatergic system will contribute to the development of strategies aimed at limiting pathological changes associated with glutamatergic dysfunctions.

    Delarbeid
    1. Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline
    Åpne denne publikasjonen i ny fane eller vindu >>Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline
    2004 (engelsk)Inngår i: Brain Research. Molecular Brain Research, ISSN 0169-328X, E-ISSN 1872-6941, Vol. 126, nr 1, s. 74-77Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Glutamate transporters regulate the glutamate concentration in the synaptic cleft within the CNS, a regulation required for normal brain function. In several neurological conditions, the amount of glutamate is altered. One reason for the changes in glutamate concentration might be impaired glutamate transporter function. In this study, an in situ hybridisation technique has been used to elucidate changes in mRNA expression of the glutamate transporter, excitatory amino acid carrier 1 (EAAC1), after treatment with the tricyclic antidepressant (TCA) amitriptyline. The results lead to the suggestion that treatment with tricyclic antidepressants leads to changes in the EAAC1 mRNA expression in rat brain suggesting involvement of the glutamate system in the tricyclic treatment of depression.

    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-24088 (URN)10.1016/j.molbrainres.2004.03.023 (DOI)000222569100009 ()3654 (Lokal ID)3654 (Arkivnummer)3654 (OAI)
    Tilgjengelig fra: 2009-10-07 Laget: 2009-10-07 Sist oppdatert: 2023-12-28
    2. Rivastigmine as a Modulator of the Neuronal Glutamate Transporter rEAAC1 mRNA Expression
    Åpne denne publikasjonen i ny fane eller vindu >>Rivastigmine as a Modulator of the Neuronal Glutamate Transporter rEAAC1 mRNA Expression
    2005 (engelsk)Inngår i: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 19, nr 1, s. 18-23Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Alzheimer’s disease is a neurodegenerative disorder that affects the cholinergic, glutamatergic and monoaminergic systems in the neocortex and hippocampus. Today, the major pharmacological treatment involves the use of acetylcholinesterase inhibitors (AChEIs). In this study, an in situ hybridisation technique (using digoxigenin-labelled cRNA probes) was used to elucidate changes in mRNA expression of the neuronal glutamate transporter, rat excitatory amino carrier 1 (rEAAC1), after treatment with the AChEI rivastigmine. Compared with saline-treated rats, the rats subchronically (3 days) and chronically (21 days), but not acutely, treated with rivastigmine showed a significant increase in rEAAC1 mRNA expression in the hippocampal areas cornu anterior 1 (CA1), CA2, CA3 and dentate gyrus (p < 0.01), but not in the cortical areas. These results provide the first evidence that the glutamatergic system is modulated following acetylcholinesterase inhibition by rivastigmine, a finding, which is likely to be of importance for the clinical effects.

    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-42255 (URN)10.1159/000080966 (DOI)000226012200004 ()62059 (Lokal ID)62059 (Arkivnummer)62059 (OAI)
    Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2023-12-28
    3. Environmental enrichment induces changes in the mRNA expression of rat EAAC1 and NMDA but not in AMPA
    Åpne denne publikasjonen i ny fane eller vindu >>Environmental enrichment induces changes in the mRNA expression of rat EAAC1 and NMDA but not in AMPA
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Interaction with the environment has a key role in refining the neuronal circuitry required for normal brain function throughout life. Profound effects of enriched environment has been shown on neuronal strucrure and chemistry in experimental animals. Epidemiological studies imply that this is true also in man, thus cognitive stimulation has a protective effect on neurodegeneration, e.g. Alzheimer's disease. Glutamatergic corticocortical pathways are imperative for cognitive functions, such as memory and learning, and long term porenriation relies on the AMPA and NMDAglutamate rcceptors. The glutamate signalling is also dependent on a fine-runed transport system, in the hippocampus primarily by theglutamate transporter EAACl. In this study we show how environmental enrichment modulates these parts of the glutamarergic system using in siru hybridization. This work demonstrates for the first time that environmental enrichment modulates the mRNA expression of EAAC1 which is significantly decreased in hippocampal and cortical areas. We also provide further evidence about the upregulation of NMDA mRNA after environmental enrichement, and show it to have a regionally and hemisphere specific regulation. The current work also confirms that AMPA mRNA is nor per se changed by environmental enrichment in adult animals. Taken together, our results extend the knowledge of the glutamatergic system and its modulation by environmental enrichment and could contribute to the development of strategies aimed at limiting pathological changes associated with glutamatergic dysfunctions.

    HSV kategori
    Identifikatorer
    urn:nbn:se:liu:diva-97633 (URN)
    Tilgjengelig fra: 2013-09-18 Laget: 2013-09-18 Sist oppdatert: 2023-12-28
  • 4.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Fransson, Peter
    Karolinska institutet, Department of Clinical Neuroscience.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Deaf signers are less reliant than hearing non-signers on fact retrieval from verbal long term memory during arithmetic processing: fMRI evidence2015Konferansepaper (Fagfellevurdert)
  • 5.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Fransson, Peter
    Karolinska institutet, Department of Clinical Neuroscience.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Greater reliance on magnitude manipulation during mental arithmetic in deaf signers compared to hearing non-signers: fMRI evidence2015Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Evidence suggests that the lag reported in mathematics for deaf signers derives from difficulties related to verbal processing of numbers, whereas magnitude processing seems unaffected by deafness. Neuroimaging evidence from hearing individuals suggests that verbal processing of numbers engages primarily left angular gyrus (lAG), whereas magnitude processing engages primarily the horizontal portion of the right intraparietal sulcus (rHIP). In a ROI analysis of brain imaging data from 16 adult deaf signers and 16 adult hearing non-signers, who did not differ on sex, age or education, we examined if activity in lAG and rHIP changed as a result of task (multiplication vs subtraction) and group (deaf signers and hearing non-signers). We found a significant main effect of brain region (F(1,30) = 117.00, p < .001, η_p^2 = .80) and an interaction effect between region and group (F(1,30) = 20.70, p < .001, η_p^2 = .41). Further analyses showed that there were no significant differences in average activation between groups in lAG (F(1,30) = 0.16, p = .70). However, in rHIP deaf signers showed significantly greater average activation compared to non-signers (F(1,30) = 15.20, p < .001, η_p^2 = .34). There were no significant differences in activation between subtraction and multiplication (F(1,30) = 0.66, p = .42) and no behavioural differences between groups (F(1,30) = 1.70, p = .20). These results suggest that when engaging in arithmetic tasks deaf signers successfully make use of qualitatively difference processes, compared to hearing non-signers, with stronger emphasis on brain regions relating to magnitude manipulation.

  • 6.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Orebro Univ, Sweden.
    Elwér, Åsa
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Pedagogik och didaktik. Linköpings universitet, Utbildningsvetenskap.
    Maki-Torkko, Elina
    Orebro Univ, Sweden.
    Arithmetic in the adult deaf signing brain2020Inngår i: Journal of Neuroscience Research, ISSN 0360-4012, E-ISSN 1097-4547, Vol. 98, nr 4, s. 643-654Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We have previously shown that deaf signers recruit partially different brain regions during simple arithmetic compared to a group of hearing non-signers, despite similar performance. Specifically, hearing individuals show more widespread activation in brain areas that have been related to the verbal system of numerical processing, i.e., the left angular and inferior frontal gyrus, whereas deaf individuals engaged brain areas that have been related to the quantity system of numerical processing, i.e., the right horizontal intraparietal sulcus. This indicates that compared to hearing non-signers, deaf signers can successfully make use of processes located in partially different brain areas during simple arithmetic. In this study, which is a conceptual replication and extension of the above-presented study, the main aim is to understand similarities and differences in neural correlates supporting arithmetic in deaf compared to hearing individuals. The primary objective is to investigate the role of the right horizontal intraparietal gyrus, the left inferior frontal gyrus, the hippocampus, and the left angular gyrus during simple and difficult arithmetic and how these regions are connected to each other. A second objective is to explore what other brain regions support arithmetic in deaf signers. Up to 34 adult deaf signers and the same amount of hearing non-signers will be enrolled in an functional magnetic resonance imaging study that will include simple and difficult subtraction and multiplication. Brain imaging data will be analyzed using whole-brain analysis, region of interest analysis and connectivity analysis. This is the first study to investigate neural underpinnings of arithmetic of different difficulties in deaf individuals.

    Fulltekst (pdf)
    fulltext
  • 7.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Elwér, Åsa
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Pedagogik och didaktik. Linköpings universitet, Utbildningsvetenskap.
    Mäki-Torkko, Elina
    Örebro University, Sweden.
    Arithmetic in the signing brain: Differences and similarities in arithmetic processing between deaf signers and hearing non-signers2023Inngår i: Journal of Neuroscience Research, ISSN 0360-4012, E-ISSN 1097-4547, Vol. 101, nr 1, s. 172-195Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Deaf signers and hearing non-signers have previously been shown to recruit partially different brain regions during simple arithmetic. In light of the triple code model, the differences were interpreted as relating to stronger recruitment of the verbal system of numerical processing, that is, left angular and inferior frontal gyrus, in hearing non-signers, and of the quantity system of numerical processing, that is, right horizontal intraparietal sulcus, for deaf signers. The main aim of the present study was to better understand similarities and differences in the neural correlates supporting arithmetic in deaf compared to hearing individuals. Twenty-nine adult deaf signers and 29 hearing non-signers were enrolled in an functional magnetic resonance imaging study of simple and difficult subtraction and multiplication. Brain imaging data were analyzed using whole-brain analysis, region of interest analysis, and functional connectivity analysis. Although the groups were matched on age, gender, and nonverbal intelligence, the deaf group performed generally poorer than the hearing group in arithmetic. Nevertheless, we found generally similar networks to be involved for both groups, the only exception being the involvement of the left inferior frontal gyrus. This region was activated significantly stronger for the hearing compared to the deaf group but showed stronger functional connectivity with the left superior temporal gyrus in the deaf, compared to the hearing, group. These results lend no support to increased recruitment of the quantity system in deaf signers. Perhaps the reason for performance differences is to be found in other brain regions not included in the original triple code model.

    Fulltekst (pdf)
    fulltext
  • 8.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Enz, Albert
    Neuroscience Research, The Novartis Institutes for BioMedical Research, Basel, Switzerland.
    Gentsch, Conrad
    Neuroscience Research, The Novartis Institutes for BioMedical Research, Basel, Switzerland.
    Marcusson, Jan
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Rivastigmine as a Modulator of the Neuronal Glutamate Transporter rEAAC1 mRNA Expression2005Inngår i: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 19, nr 1, s. 18-23Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Alzheimer’s disease is a neurodegenerative disorder that affects the cholinergic, glutamatergic and monoaminergic systems in the neocortex and hippocampus. Today, the major pharmacological treatment involves the use of acetylcholinesterase inhibitors (AChEIs). In this study, an in situ hybridisation technique (using digoxigenin-labelled cRNA probes) was used to elucidate changes in mRNA expression of the neuronal glutamate transporter, rat excitatory amino carrier 1 (rEAAC1), after treatment with the AChEI rivastigmine. Compared with saline-treated rats, the rats subchronically (3 days) and chronically (21 days), but not acutely, treated with rivastigmine showed a significant increase in rEAAC1 mRNA expression in the hippocampal areas cornu anterior 1 (CA1), CA2, CA3 and dentate gyrus (p < 0.01), but not in the cortical areas. These results provide the first evidence that the glutamatergic system is modulated following acetylcholinesterase inhibition by rivastigmine, a finding, which is likely to be of importance for the clinical effects.

  • 9.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Fransson, Peter
    Karolinska Institutet.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Deaf signers and hearing non-signers recruit similar networks for arithmetic and phonological tasks2013Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    Profoundly deaf individuals sometimes have difficulty with arithmetic and phonological tasks. In the present study we investigate if these differences can be attributed to differences in recruitment of neurobiological networks. Seventeen hearing non-signers (HN) and sixteen deaf signers (DS) matched on age, gender and non-verbal intelligence took part in an fMRI study. In the scanner three digit/letter pairs were visually presented and the participants performed six different blocked tasks tapping processing of digit and letter order, multiplication, subtraction and phonological ability. Data were analysed using two 2x2x2 ANOVAs; process (arithmetic, language) x level (high, low) x group (DS, HN). A main effect of process revealed language networks in the left inferior frontal gryus, supramarginal gyrus, fusiform gyrus and insula. Arithmetic networks included left middle orbital gyrus and superior medial gyrus. A main effect of level revealed low level processing (digit/letter order) in the right middle occipital gyrus and the right precuneus and high level processing (subtraction/multiplication/phonological ability) in left inferior frontal gyrus. There was no main effect of group but a significant task x group interaction in the right temporal pole which in DS (but not HN) was activated more for arithmetic than language processing (pfwe = .022) when multiplication was included in the analysis. This region is implicated in conceptual representation. These results suggest that both arithmetic and language are processed similarly by DS and HN with possible between-group differences in the use of conceptual representation in arithmetic and language tasks.

  • 10.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Fransson, Peter
    Department of Clinical Neuroscience, Karolinska institute, Stockholm, Sweden.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Deaf signers use magnitude manipulatioin strategies for mulitplication: fMRI evidence2014Manuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Evidence suggests that the lag reported in mathematics for deaf signers derives from difficulties related to the verbal system of number processing as described in the triple code model. For hearing individuals the verbal system has been shown to be recruited for both arithmetic and language tasks. In the present study we investigate for the first time neuronal representations of arithmetic in deaf signers. We examine if the neural network supporting arithmetic and language, including the horizontal portion of the intraparietal sulcus (HIPS), the superior parietal lobule (SPL) bilaterally, the left angular gyrus (AG), pars opercularis (POPE) and pars triangularis (PTRI) of the left inferior frontal gyrus (IFG), is differently recruited for deaf and hearing individuals. Imaging data were collected from 16 deaf signers and 16 well-matched hearing nonsigners, using the same stimulus material for all tasks, but with different cues. During multiplication, deaf signers recruited rHIPS more than hearing non-signers, suggesting greater involvement of magnitude manipulation processes related to the quantity system, whereas there was no evidence that the verbal system was recruited. Further, there was no support for the notion of a common representation of phonology for sign and speech as previously suggested.

  • 11.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Fransson, Peter
    Karolinska institutet, Stockholm.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Multiplication engages phonological networks in Broca's area differently for deaf signers and hearing non-signers2012Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    In hearing individuals, multiplication relies mainly on the phonological loop while subtraction relies on the visuo-spatial sketchpad (VSSP; Lee & Kang, 2002). Little is known about arithmetic neural networks in deaf signers (DS). Since DS often perform worse than hearing non-signers (NH) on arithmetic in general and multiplication in particular (Traxler, 2000), we hypothesized that there are strategic differences between how groups recruit the phonological loop in multiplication, but not in subtraction, leading to differential activation of phonological processing areas in left inferior frontal gyrus (Broca’s area). We investigated this using a blocked fMRI-design in which nine DS and 17 HN matched on age, gender, education and non-verbal intelligence (Raven & Raven, 1998) were tested on tasks of multiplication, subtraction and phonology (rhyme). The contrasts rhyme versus multiplication and rhyme versus subtraction were examined across groups within the region of interest defined by a probability map of Broca’s area (Amunts, 1999). We observed a significant interaction between task (multiplication and rhyme) and group (F = 12.64, p = .034, FWE-corrected), where the HN showed higher activation for rhyme than for multiplication (T = 4.55, p = .001, FWE-corrected) whereas there were no differences in activations between tasks for DS. For subtraction versus rhyme no interaction with group was found. These results suggest that there are differences between DS and HN in the phonology dependent neural networks in Broca’s area used during multiplication, which may be part of the explanation for poorer performance in DS.

  • 12.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Fransson, Peter
    Karolinska Inst, Sweden.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    The neural basis of arithmetic and phonology in deaf signing individuals2019Inngår i: Language, Cognition and Neuroscience, ISSN 2327-3798, E-ISSN 2327-3801, Vol. 34, nr 7, s. 813-825Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Deafness is generally associated with poor mental arithmetic, possibly due to neuronal differences in arithmetic processing across language modalities. Here, we investigated for the first time the neuronal networks supporting arithmetic processing in adult deaf signers. Deaf signing adults and hearing non-signing peers performed arithmetic and phonological tasks during fMRI scanning. At whole brain level, activation patterns were similar across groups. Region of interest analyses showed that although both groups activated phonological processing regions in the left inferior frontal gyrus to a similar extent during both phonological and multiplication tasks, deaf signers showed significantly more activation in the right horizontal portion of the inferior parietal sulcus. This region is associated with magnitude manipulation along the mental number line. This pattern of results suggests that deaf signers rely more on magnitude manipulation than hearing non-signers during multiplication, but that phonological involvement does not differ significantly between groups.Abbreviations: AAL: Automated Anatomy Labelling; fMRI: functional magnetic resonance imaging; HIPS: horizontal portion of the intraparietal sulcus; lAG: left angular gyrus; lIFG: left inferior frontal gyrus; rHIPS: right horizontal portion of the intraparietal sulcus

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  • 13.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Fransson, Peter
    Karolinska University Hospital, Stockholm, Sweden.
    Ingvar, Martin
    Karolinska University Hospital, Stockholm, Sweden.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Phonological processing during arithmetic processing across language modalities2011Konferansepaper (Annet vitenskapelig)
  • 14.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Fransson, Peter
    Karolinska University Hospital, Stockholm.
    Ingvar, Martin
    Karolinska University Hospital, Stockholm.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Phonological recruitment during arithmetic processing across language modalities2011Konferansepaper (Annet vitenskapelig)
  • 15.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Fransson, Peter
    Karolinska Inst, Sweden.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    fMRI Evidence of Magnitude Manipulation during Numerical Order Processing in Congenitally Deaf Signers2018Inngår i: Neural Plasticity, ISSN 2090-5904, E-ISSN 1687-5443, artikkel-id 2576047Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Congenital deafness is often compensated by early sign language use leading to typical language development with corresponding neural underpinnings. However, deaf individuals are frequently reported to have poorer numerical abilities than hearing individuals and it is not known whether the underlying neuronal networks differ between groups. In the present study, adult deaf signers and hearing nonsigners performed a digit and letter order tasks, during functional magnetic resonance imaging. We found the neuronal networks recruited in the two tasks to be generally similar across groups, with significant activation in the dorsal visual stream for the letter order task, suggesting letter identification and position encoding. For the digit order task, no significant activation was found for either of the two groups. Region of interest analyses on parietal numerical processing regions revealed different patterns of activation across groups. Importantly, deaf signers showed significant activation in the right horizontal portion of the intraparietal sulcus for the digit order task, suggesting engagement of magnitude manipulation during numerical order processing in this group.

  • 16.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Fransson, Peter
    Karolinska Institute, Sweden.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Phonology and arithmetic in the language-calculation network2015Inngår i: Brain and Language, ISSN 0093-934X, E-ISSN 1090-2155, Vol. 143, s. 97-105Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Arithmetic and language processing involve similar neural networks, but the relative engagement remains unclear. In the present study we used fMRI to compare activation for phonological, multiplication and subtraction tasks, keeping the stimulus material constant, within a predefined language-calculation network including left inferior frontal gyrus and angular gyrus (AG) as well as superior parietal lobule and the intraparietal sulcus bilaterally. Results revealed a generally left lateralized activation pattern within the language-calculation network for phonology and a bilateral activation pattern for arithmetic, and suggested regional differences between tasks. In particular, we found a more prominent role for phonology than arithmetic in pars opercularis of the left inferior frontal gyrus but domain generality in pars triangularis. Parietal activation patterns demonstrated greater engagement of the visual and quantity systems for calculation than language. This set of findings supports the notion of a common, but regionally differentiated, language-calculation network. (C) 2015 The Authors. Published by Elsevier Inc.

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  • 17.
    Andin, Josefine
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik.
    Hallbeck, Martin
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för biomedicin och kirurgi, Avdelningen för medicinsk cellbiologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk patologi och klinisk genetik.
    Mohammed, Abdul H
    Marcusson, Jan
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Östergötlands Läns Landsting, Närsjukvården i centrala Östergötland, Geriatriska kliniken.
    Influence of environmental enrichment on steady-state mRNA levels for EAAC1, AMPA1 and NMDA2A receptor subunits in rat hippocampus2007Inngår i: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1174, nr 1, s. 18-27Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Interaction with the environment has a key role in refining the neuronal circuitry required for normal brain function throughout life. Profound effects of enriched environment have been shown on neuronal structure and chemistry in experimental animals. Epidemiological studies imply that this is true also in man, thus cognitive stimulation has a protective effect on neurodegeneration, e.g., in Alzheimer's disease. Glutamatergic pathways are imperative for cognitive functions, such as memory, learning and long-term potentiation, and relies on the AMPA and NMDA glutamate receptors and the hippocampus, with its specific subregions, is an important anatomical substrate in this. The glutamate signalling is also dependent on a fine-tuned transport system, in the hippocampus primarily achieved by the glutamate transporter EAAC1. In this study we show how environmental enrichment modulates these parts of the glutamatergic system using quantitative in situ hybridisation. This work demonstrates for the first time that environmental enrichment modulates the mRNA expression of EAAC1 which is significantly and region specifically decreased in the hippocampus. We also provide evidence for regional and hemisphere-specific upregulation of NMDA mRNA in the hippocampus after environmental enrichment. The current work also shows that AMPA mRNA of the hippocampus is not per se changed by environmental enrichment in adult animals. Taken together, our results extend the knowledge of the glutamatergic system of specific regions of the hippocampus and its modulation by environmental enrichment and could contribute to the development of strategies aimed at limiting pathological changes associated with glutamatergic dysfunctions. © 2007.

  • 18.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Hallbeck, Martin
    Mohammed, Abdul
    Division of Geriatric Medicine, Neurontec, Karolinska Institutet, Sweden.
    Marcusson, Jan
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Environmental enrichment induces changes in the mRNA expression of rat EAAC1 and NMDA but not in AMPAManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Interaction with the environment has a key role in refining the neuronal circuitry required for normal brain function throughout life. Profound effects of enriched environment has been shown on neuronal strucrure and chemistry in experimental animals. Epidemiological studies imply that this is true also in man, thus cognitive stimulation has a protective effect on neurodegeneration, e.g. Alzheimer's disease. Glutamatergic corticocortical pathways are imperative for cognitive functions, such as memory and learning, and long term porenriation relies on the AMPA and NMDAglutamate rcceptors. The glutamate signalling is also dependent on a fine-runed transport system, in the hippocampus primarily by theglutamate transporter EAACl. In this study we show how environmental enrichment modulates these parts of the glutamarergic system using in siru hybridization. This work demonstrates for the first time that environmental enrichment modulates the mRNA expression of EAAC1 which is significantly decreased in hippocampal and cortical areas. We also provide further evidence about the upregulation of NMDA mRNA after environmental enrichement, and show it to have a regionally and hemisphere specific regulation. The current work also confirms that AMPA mRNA is nor per se changed by environmental enrichment in adult animals. Taken together, our results extend the knowledge of the glutamatergic system and its modulation by environmental enrichment and could contribute to the development of strategies aimed at limiting pathological changes associated with glutamatergic dysfunctions.

  • 19.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Holmer, Emil
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Reorganization of large-scale brain networks in deaf signing adults: The role of auditory cortex in functional reorganization following deafness2022Inngår i: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 166, artikkel-id 108139Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    If the brain is deprived of input from one or more senses during development, functional and structural reorganization of the deprived regions takes place. However, little is known about how sensory deprivation affects large-scale brain networks. In the present study, we use data-driven independent component analysis (ICA) to characterize large-scale brain networks in 15 deaf early signers and 24 hearing non-signers based on resting-state functional MRI data. We found differences between the groups in independent components representing the left lateralized control network, the default network, the ventral somatomotor network, and the attention network. In addition, we showed stronger functional connectivity for deaf compared to hearing individuals from the middle and superior temporal cortices to the cingulate cortex, insular cortex, cuneus and precuneus, supramarginal gyrus, supplementary motor area, and cerebellum crus 1, and stronger connectivity for hearing non-signers to hippocampus, middle and superior frontal gyri, pre- and postcentral gyri, and cerebellum crus 8. These results show that deafness induces large-scale network reorganization, with the middle/superior temporal cortex as a central node of plasticity. Cross-modal reorganization may be associated with behavioral adaptations to the environment, including superior ability in some visual functions such as visual working memory and visual attention, in deaf signers.

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  • 20.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Holmer, Emil
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Krister, Schönström
    Department of Linguistics, Stockholm University, Stockholm, Sweden.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Swedish Institute for Disability Research, Linnaeus Centre HEAD, Sweden.
    Working Memory for Signs with Poor Visual Resolution: fMRI Evidence of Reorganizationof Auditory Cortex in Deaf Signers2021Inngår i: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 31, nr 7, s. 3165-3176Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Stimulus degradation adds to working memory load during speech processing.We investigated whether this applies to signprocessing and, if so, whether the mechanism implicates secondary auditory cortex.We conducted an fMRI experimentwhere 16 deaf early signers (DES) and 22 hearing non-signers performed a sign-based n-back task with three load levels andstimuli presented at high and low resolution.We found decreased behavioral performance with increasing load anddecreasing visual resolution, but the neurobiological mechanisms involved differed between the two manipulations and didso for both groups. Importantly, while the load manipulation was, as predicted, accompanied by activation in thefrontoparietal working memory network, the resolution manipulation resulted in temporal and occipital activation.Furthermore, we found evidence of cross-modal reorganization in the secondary auditory cortex: DES had strongeractivation and stronger connectivity between this and several other regions.We conclude that load and stimulus resolutionhave different neural underpinnings in the visual–verbal domain, which has consequences for current working memorymodels, and that for DES the secondary auditory cortex is involved in the binding of representations when task demandsare low.

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  • 21.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Orfanidou, Eleni
    University of Crete, Rethymnon, Greece.
    Cardin, Velia
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. University College London, UK.
    Holmer, Emil
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Capek, Cheryl M.
    School of Psychological Science, University of Manchester, UK.
    Woll, Bencie
    University College London, UK.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Similar digit-based working memory in deaf signers and hearing non-signers despite digit span differences2013Inngår i: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 4, nr 942Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Similar working memory (WM) for lexical items has been demonstrated for signers and non-signers while short-term memory (STM) is regularly poorer in deaf than hearing individuals. In the present study, we investigated digit-based WM and STM in Swedish and British deaf signers and hearing non-signers. To maintain good experimental control we used printed stimuli throughout and held response mode constant across groups. We showed that deaf signers have similar digit-based WM performance, despite shorter digit spans, compared to well-matched hearing non-signers. We found no difference between signers and non-signers on STM span for letters chosen to minimize phonological similarity or in the effects of recall direction. This set of findings indicates that similar WM for signers and non-signers can be generalized from lexical items to digits and suggests that poorer STM in deaf signers compared to hearing non-signers may be due to differences in phonological similarity across the language modalities of sign and speech.

    Fulltekst (pdf)
    fulltext
  • 22.
    Andin, Josefine
    et al.
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD).
    Rudner, Mary
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD).
    Rönnberg, Jerker
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap.
    Arithmetic and phonological processes in deaf native signers2008Inngår i: The first meeting of the federation of the European societies of neuropsychology,2008, 2008Konferansepaper (Annet vitenskapelig)
  • 23.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Arithmetic and phonological processes in deaf signers and hearing non-signers - a cognitive study2008Konferansepaper (Annet vitenskapelig)
  • 24.
    Andin, Josefine
    et al.
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD).
    Rudner, Mary
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD).
    Rönnberg, Jerker
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap.
    Arithmetic and phonological processing in deaf native signers and hearing non-signers2008Inngår i: First European Congress of Neuropsychology,2008, 2008Konferansepaper (Annet vitenskapelig)
  • 25.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Complex symbol precessing in deaf native signers and hearing non-signers2009Konferansepaper (Annet vitenskapelig)
  • 26.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Deaf signers use phonology to do arithmetic2014Inngår i: Learning and individual differences, ISSN 1041-6080, E-ISSN 1873-3425, Vol. 32, s. 246-253Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Deaf students generally lag several years behind hearing peers in arithmetic, but little is known about the mechanisms behind this. In the present study we investigated how phonological skills interact with arithmetic. Eighteen deaf signers and eighteen hearing non-signers took part in an experiment that manipulated arithmetic and phonological knowledge in the language modalities of sign and speech. Independent tests of alphabetical and native language phonological skills were also administered. There was no difference in performance between groups on subtraction, but hearing non-signers performed better than deaf signers on multiplication. For the deaf signers but not the hearing non-signers, multiplicative reasoning was associated with both alphabetical and phonological skills. This indicates that deaf signing adults rely on language processes to solve multiplication tasks, possibly because automatization of multiplication is less well established in deaf adults.

    Fulltekst (pdf)
    Fulltext
  • 27.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Dealing with digits: short-term memory differences in deaf signers and hearing non-signers2011Artikkel i tidsskrift (Fagfellevurdert)
  • 28.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Language modality specific affects on simple spans in deaf signers and hearing non-signers2010Inngår i: Second European Congress of Neuropsychology, September, Amsterdam, 2010Konferansepaper (Fagfellevurdert)
  • 29.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Language modality specific effects on simple spans in deaf signers and hearing non-signers2010Konferansepaper (Annet vitenskapelig)
  • 30.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Phonological similarity and sensory memory traces modulate span size in deaf signers and hearing non-signers2010Konferansepaper (Annet vitenskapelig)
  • 31.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rhyme and Reason - do deaf signers use phonology to do arithmetic?2010Konferansepaper (Annet vitenskapelig)
  • 32.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD). Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD). Linköpings universitet, Filosofiska fakulteten.
    Simple spans in deaf signers and hearing non-signers2010Inngår i: BEHAVIOURAL NEUROLOGY, ISSN 0953-4180, Vol. 23, nr 4, s. 207-208Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    n/a

    Fulltekst (pdf)
    fulltext
  • 33.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköping University, Linnaeus Centre HEAD.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköping University, Linnaeus Centre HEAD.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköping University, Linnaeus Centre HEAD.
    Simple spans in deaf signers and hearing nonsigners2010Inngår i: Behavioural Neurology, ISSN 0953-4180, E-ISSN 1875-8584, Vol. 23, nr 4, s. 207-208Artikkel i tidsskrift (Fagfellevurdert)
  • 34.
    Andin, Josefine
    et al.
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Stenfors, Carina
    Bioscience, Local Discovery, AstraZeneca R&D, Södertälje, Sweden.
    Ross, Svante B
    Bioscience, Local Discovery, AstraZeneca R&D, Södertälje, Sweden.
    Marcusson, Jan
    Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik. Linköpings universitet, Hälsouniversitetet.
    Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline2004Inngår i: Brain Research. Molecular Brain Research, ISSN 0169-328X, E-ISSN 1872-6941, Vol. 126, nr 1, s. 74-77Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Glutamate transporters regulate the glutamate concentration in the synaptic cleft within the CNS, a regulation required for normal brain function. In several neurological conditions, the amount of glutamate is altered. One reason for the changes in glutamate concentration might be impaired glutamate transporter function. In this study, an in situ hybridisation technique has been used to elucidate changes in mRNA expression of the glutamate transporter, excitatory amino acid carrier 1 (EAAC1), after treatment with the tricyclic antidepressant (TCA) amitriptyline. The results lead to the suggestion that treatment with tricyclic antidepressants leads to changes in the EAAC1 mRNA expression in rat brain suggesting involvement of the glutamate system in the tricyclic treatment of depression.

  • 35.
    Cardin, Velia
    et al.
    University College London, Division of Psychology and Language Sciences.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    De Oliveira, Rita
    London South Bank University.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Beese, Lilli
    University College London, Deafness Cognition and Language Research Centre.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Working memory and crossmodal plasticity in congenitally deaf individuals2015Konferansepaper (Annet vitenskapelig)
  • 36.
    Cardin, Velia
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). UCL, England; Univ East Anglia, England.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    De Oliveira, Rita F.
    London South Bank Univ, England.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Su, Merina T.
    UCL GOS Inst Child Hlth, England.
    Beese, Lilli
    UCL, England.
    Woll, Bencie
    UCL, England.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    The Organization of Working Memory Networks is Shaped by Early Sensory Experience2018Inngår i: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 28, nr 10, s. 3540-3554Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Early deafness results in crossmodal reorganization of the superior temporal cortex (STC). Here, we investigated the effect of deafness on cognitive processing. Specifically, we studied the reorganization, due to deafness and sign language (SL) knowledge, of linguistic and nonlinguistic visual working memory (WM). We conducted an fMRI experiment in groups that differed in their hearing status and SL knowledge: deaf native signers, and hearing native signers, hearing nonsigners. Participants performed a 2-back WM task and a control task. Stimuli were signs from British Sign Language (BSL) or moving nonsense objects in the form of point-light displays. We found characteristic WM activations in fronto-parietal regions in all groups. However, deaf participants also recruited bilateral posterior STC during the WM task, independently of the linguistic content of the stimuli, and showed less activation in fronto-parietal regions. Resting-state connectivity analysis showed increased connectivity between frontal regions and STC in deaf compared to hearing individuals. WM for signs did not elicit differential activations, suggesting that SL WM does not rely on modality-specific linguistic processing. These findings suggest that WM networks are reorganized due to early deafness, and that the organization of cognitive networks is shaped by the nature of the sensory inputs available during development.

  • 37.
    Cardin, Velia
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande. University College London, Division of Psychology and Language Sciences.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Ferraz De Oliveira, Rita
    London South Bank University, School of Applied Science.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Beese, Lilli
    University College London, Deafness Cognition and Language Research Centre.
    Woll, Bencie
    Linköpings universitet, Institutionen för beteendevetenskap och lärande. University College London, Division of Psychology and Language Sciences.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    A working memory role for superior temporal cortex in deaf individuals independently of linguistic content2015Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Studies of sign languages have been used to test traditional cognitive models of working memory (WM) that distinguish between verbal and visuospatial WM (e.g. Baddeley, 2003), without considering that sign languages operate in the visuospatial domain. Previous studies have shown that WM mental representations and processes are largely similar for signed and spoken languages (e.g. Rönnberg et al., 2004). However, it is not clear to what extent visual WM processes aid and support sign language WM.

    Here we characterise the neural substrates supporting sign language and visual WM, and the mechanisms that subserve differential processing for signers and for deaf individuals. We conducted a functional magnetic resonance imaging (fMRI) experiment with three groups of participants: deaf native signers, hearing native signers and hearing non-signers. Participants performed a 2-back WM task and a control task on two sets of stimuli: signs from British Sign Language or non-sense objects. Stimuli were composed of point-lights to control for differences in visual features.

    Our results show activation in a fronto-parietal network for WM processing in all groups, independently of stimulus type, in agreement with previous literature. We also replicate previous findings in deaf signers showing a stronger right posterior superior temporal cortex (STC) activation for visuospatial processing, and stronger bilateral STC activation for sign language stimuli.

    Group comparisons further reveal stronger activations in STC for WM in deaf signers, but not for the groups of hearing individuals. This activation is independent of the linguistic content of the stimuli, being observed in both WM conditions: signs and objects. These results suggest a cognitive role for STC in deaf signers, beyond sign language processing.

  • 38.
    Cardin, Velia
    et al.
    University College London, Division of Psychology and Language Sciences.
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Ferraz de Oliveira, Rita
    London South Bank University, School of Applied Science.
    Su, Merina
    London South Bank University, Institute of Child Health.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Beese, Lilli
    University College London, Deafness Cognition and Language Research Centre.
    Woll, Bencie
    University College London, Division of Psychology and Language Sciences.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköping University, Linnaeus Centre HEAD.
    Does the superior temporal cortex have a role in cognitive control as a consequence of cross-modal reorganization?2015Konferansepaper (Fagfellevurdert)
  • 39.
    Ekberg, Mattias
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Stenfelt, Stefan
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för sinnesorgan och kommunikation. Linköpings universitet, Medicinska fakulteten.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Effects of mild-to-moderate sensorineuralhearing loss and signal amplification on vocalemotion recognition in middle-aged–olderindividuals2022Inngår i: PLOS ONE, E-ISSN 1932-6203, Vol. 17, nr 1, artikkel-id e0261354Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Previous research has shown deficits in vocal emotion recognition in sub-populations of individuals with hearing loss, making this a high priority research topic. However, previousresearch has only examined vocal emotion recognition using verbal material, in which emotions are expressed through emotional prosody. There is evidence that older individualswith hearing loss suffer from deficits in general prosody recognition, not specific to emotionalprosody. No study has examined the recognition of non-verbal vocalization, which constitutes another important source for the vocal communication of emotions. It might be thecase that individuals with hearing loss have specific difficulties in recognizing emotionsexpressed through prosody in speech, but not non-verbal vocalizations. We aim to examinewhether vocal emotion recognition difficulties in middle- aged-to older individuals with sensorineural mild-moderate hearing loss are better explained by deficits in vocal emotion recognition specifically, or deficits in prosody recognition generally by including both sentencesand non-verbal expressions. Furthermore a, some of the studies which have concluded thatindividuals with mild-moderate hearing loss have deficits in vocal emotion recognition abilityhave also found that the use of hearing aids does not improve recognition accuracy in thisgroup. We aim to examine the effects of linear amplification and audibility on the recognitionof different emotions expressed both verbally and non-verbally. Besides examining accuracy for different emotions we will also look at patterns of confusion (which specific emotionsare mistaken for other specific emotion and at which rates) during both amplified and nonamplified listening, and we will analyze all material acoustically and relate the acoustic content to performance. Together these analyses will provide clues to effects of amplification onthe perception of different emotions. For these purposes, a total of 70 middle-aged-olderindividuals, half with mild-moderate hearing loss and half with normal hearing will perform acomputerized forced-choice vocal emotion recognition task with and without amplification

    Fulltekst (pdf)
    fulltext
  • 40.
    Ekberg, Mattias
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Stavrinos, Georgios
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Filosofiska fakulteten.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Stenfelt, Stefan
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för sinnesorgan och kommunikation. Linköpings universitet, Medicinska fakulteten.
    Dahlström, Örjan
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Filosofiska fakulteten.
    Acoustic Features Distinguishing Emotions in Swedish Speech.2023Inngår i: Journal of Voice, ISSN 0892-1997, E-ISSN 1873-4588, artikkel-id S0892-1997(23)00103-0Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Few studies have examined which acoustic features of speech can be used to distinguish between different emotions, and how combinations of acoustic parameters contribute to identification of emotions. The aim of the present study was to investigate which acoustic parameters in Swedish speech are most important for differentiation between, and identification of, the emotions anger, fear, happiness, sadness, and surprise in Swedish sentences. One-way ANOVAs were used to compare acoustic parameters between the emotions and both simple and multiple logistic regression models were used to examine the contribution of different acoustic parameters to differentiation between emotions. Results showed differences between emotions for several acoustic parameters in Swedish speech: surprise was the most distinct emotion, with significant differences compared to the other emotions across a range of acoustic parameters, while anger and happiness did not differ from each other on any parameter. The logistic regression models showed that fear was the best-predicted emotion while happiness was most difficult to predict. Frequency- and spectral-balance-related parameters were best at predicting fear. Amplitude- and temporal-related parameters were most important for surprise, while a combination of frequency-, amplitude- and spectral balance-related parameters are important for sadness. Assuming that there are similarities between acoustic models and how listeners infer emotions in speech, results suggest that individuals with hearing loss, who lack abilities of frequency detection, may compared to normal hearing individuals have difficulties in identifying fear in Swedish speech. Since happiness and fear relied primarily on amplitude- and spectral-balance-related parameters, detection of them are probably facilitated more by hearing aid use.

    Fulltekst (pdf)
    fulltext
  • 41.
    Holmer, Emil
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Rudner, Mary
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Evidence of an Effect of Gaming Experience on Visuospatial Attention in Deaf but Not in Hearing Individuals2020Inngår i: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 11, artikkel-id 534741Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Auditory cortex in congenitally deaf early sign language users reorganizes to support cognitive processing in the visual domain. However, evidence suggests that the potential benefits of this reorganization are largely unrealized. At the same time, there is growing evidence that experience of playing computer and console games improves visual cognition, in particular visuospatial attentional processes. In the present study, we investigated in a group of deaf early signers whether those who reported recently playing computer or console games (deaf gamers) had better visuospatial attentional control than those who reported not playing such games (deaf non-gamers), and whether any such effect was related to cognitive processing in the visual domain. Using a classic test of attentional control, the Eriksen Flanker task, we found that deaf gamers performed on a par with hearing controls, while the performance of deaf non-gamers was poorer. Among hearing controls there was no effect of gaming. This suggests that deaf gamers may have better visuospatial attentional control than deaf non-gamers, probably because they are less susceptible to parafoveal distractions. Future work should examine the robustness of this potential gaming benefit and whether it is associated with neural plasticity in early deaf signers, as well as whether gaming intervention can improve visuospatial cognition in deaf people.

    Fulltekst (pdf)
    fulltext
  • 42.
    Holmer, Emil
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Schönström, Krister
    Stockholm Univ, Sweden.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Associations Between Sign Language Skills and Resting-State Functional Connectivity in Deaf Early Signers2022Inngår i: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 13, artikkel-id 738866Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The processing of a language involves a neural language network including temporal, parietal, and frontal cortical regions. This applies to spoken as well as signed languages. Previous research suggests that spoken language proficiency is associated with resting-state functional connectivity (rsFC) between language regions and other regions of the brain. Given the similarities in neural activation for spoken and signed languages, rsFC-behavior associations should also exist for sign language tasks. In this study, we explored the associations between rsFC and two types of linguistic skills in sign language: phonological processing skill and accuracy in elicited sentence production. Fifteen adult, deaf early signers were enrolled in a resting-state functional magnetic resonance imaging (fMRI) study. In addition to fMRI data, behavioral tests of sign language phonological processing and sentence reproduction were administered. Using seed-to-voxel connectivity analysis, we investigated associations between behavioral proficiency and rsFC from language-relevant nodes: bilateral inferior frontal gyrus (IFG) and posterior superior temporal gyrus (STG). Results showed that worse sentence processing skill was associated with stronger positive rsFC between the left IFG and left sensorimotor regions. Further, sign language phonological processing skill was associated with positive rsFC from right IFG to middle frontal gyrus/frontal pole although this association could possibly be explained by domain-general cognitive functions. Our findings suggest a possible connection between rsFC and developmental language outcomes in deaf individuals.

    Fulltekst (pdf)
    fulltext
  • 43.
    Kilman, Lisa
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Pedagogik och didaktik. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Andin, JosefineLinköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).Hua, HåkanCochlear Bone Anchored Solutions AB.Rönnberg, JerkerLinköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Leva som andra: Ett biopsykosocialt perspektiv på funktionsnedsättning och funktionshinder2021Collection/Antologi (Annet vitenskapelig)
  • 44.
    Rudner, Mary
    et al.
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD).
    Andin, Josefine
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD).
    Rönnberg, Jerker
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap.
    Differences in temporal and spatial processing mechanisms in working memory for signed and spoken language2009Inngår i: The 11th European congress of Psychology, Oslo, Norway, 7-10 July 2009.,2009, 2009Konferansepaper (Fagfellevurdert)
    Abstract [en]

     Objectives Working memory (WM) capacity is similar for signed (SL) and spoken (SpL) language yet underlying temporal and spatial processing mechanisms may not be identical. To investigate this, two studies with deaf native signers (DS) and hearing non-signers (HN) were conducted. Methods DS and matched HN groups performed WM tasks with varying temporal and spatial demands in study 1 at encoding (temporal, spatial and mixed presentation styles) and in study 2 at retrieval (forward and backward span) and with abstract spatial demands (math span). Results DS performance was inferior with high temporal demands at encoding (temporal style) and retreival (forward span). There was no difference between groups with high spatial order demands at encoding (spatial style) or retrieval (backward span). DS performance was worse when abstract spatial processing was involved (math span). Conclusion WM processing mechanisms for SL and SpL differ for temporal information at encoding and retrieval and for abstract spatial information. 

  • 45.
    Rudner, Mary
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD). Linköpings universitet, Filosofiska fakulteten.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för kognition, utveckling och handikapp (CDD). Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Working memory, deafness and sign language.2009Inngår i: Scandinavian journal of psychology, ISSN 1467-9450, Vol. 50, nr 5, s. 495-505Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Working memory (WM) for sign language has an architecture similar to that for speech-based languages at both functional and neural levels. However, there are some processing differences between language modalities that are not yet fully explained, although a number of hypotheses have been mooted. This article reviews some of the literature on differences in sensory, perceptual and cognitive processing systems induced by auditory deprivation and sign language use and discusses how these differences may contribute to differences in WM architecture for signed and speech-based languages. In conclusion, it is suggested that left-hemisphere reorganization of the motion-processing system as a result of native sign-language use may interfere with the development of the order processing system in WM.

    Fulltekst (pdf)
    fulltext
  • 46.
    Rudner, Mary
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Andin, Josefine
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande. Linköpings universitet, Filosofiska fakulteten.
    Rönnberg, Jerker
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Heimann, Mikael
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande. Linköpings universitet, Filosofiska fakulteten.
    Hermansson, Anders
    Sweden and Psychiatric Clinic Höglandet Hospital Eksjö/Nässjö, Sweden.
    Nelson, Keith
    Pennsylvania State University, USA.
    Tjus, Tomas
    University of Gothenburg, Sweden.
    Training Literacy Skills through Sign Language2014Inngår i: Deafness and Education International, ISSN 1464-3154, E-ISSN 1557-069X, Vol. 17, nr 1, s. 8-18Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The literacy skills of deaf children generally lag behind those of their hearing peers. The mechanisms of reading in deaf individuals are only just beginning to be unraveled but it seems that native language skills play an important role. In this study 12 deaf pupils (six in grades 1?2 and six in grades 4?6) at a Swedish state primary school for deaf and hard of hearing children were trained on the connection between Swedish Sign Language and written Swedish using a pilot sign language version of the literacy training software program Omega-is. Literacy skills improved substantially across the 20 days of the study. These literacy gains may have rested upon the specific software-based intervention, upon regular classroom activities, or upon a combination of these factors. Omega-is-d, and similar software utilizing sign language as a component, targets an important mechanism supporting reading development in deaf children and could play an important role in bilingual education refinements.

  • 47.
    Rudner, Mary
    et al.
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Psykologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Nilsson, Karin
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Filosofiska fakulteten.
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Schönström, Krister
    Stockholms Universitet, Stockholm, Sweden.
    Holmer, Emil
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Teckenspråk och kognition2021Inngår i: Leva som andra: Ett biopsykosocialt perspektiv på funktionsnedsättning och funktionshinder / [ed] Håkan Hua, Lisa Kilman, Josefine Andin, Jerker Rönnberg, Lund: Studentlitteratur AB, 2021, s. 289-308Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 48.
    Rudner, Mary
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Orfanidou, Eleni
    University of Crete, Department of Psychology.
    Capek, Sheryl M.
    University of Manchester.
    Andin, Josefine
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Karlsson, Thomas
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Dahlström, Örjan
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Kästner, Lena
    Ruhr-University, Bochum.
    Cardin, Velia
    University College London, Department of Cognitive, Perceptual and Brain Sciences.
    Fransson, Peter
    Karolinska University Hospital, Stockholm, Sweden.
    Ingvar, Martin
    Karolinska University Hospital, Stockholm, Sweden.
    Johnsrude, Ingrid
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Woll, Benice
    University College London, Cognitive, Perceptual and Brain Sciences.
    Rönnberg, Jerker
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Sign Language phonology and its role in neurocognition2011Konferansepaper (Annet vitenskapelig)
  • 49.
    Rönnberg, Jerker
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Signoret, Carine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Andin, Josefine
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutet för handikappvetenskap (IHV).
    Holmer, Emil
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för funktionsnedsättning och samhälle. Linköpings universitet, Filosofiska fakulteten.
    The cognitive hearing science perspective on perceiving, understanding, and remembering language: The ELU model2022Inngår i: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 13, artikkel-id 967260Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The review gives an introductory description of the successive development of data patterns based on comparisons between hearing-impaired and normal hearing participants speech understanding skills, later prompting the formulation of the Ease of Language Understanding (ELU) model. The model builds on the interaction between an input buffer (RAMBPHO, Rapid Automatic Multimodal Binding of PHOnology) and three memory systems: working memory (WM), semantic long-term memory (SLTM), and episodic long-term memory (ELTM). RAMBPHO input may either match or mismatch multimodal SLTM representations. Given a match, lexical access is accomplished rapidly and implicitly within approximately 100-400 ms. Given a mismatch, the prediction is that WM is engaged explicitly to repair the meaning of the input - in interaction with SLTM and ELTM - taking seconds rather than milliseconds. The multimodal and multilevel nature of representations held in WM and LTM are at the center of the review, being integral parts of the prediction and postdiction components of language understanding. Finally, some hypotheses based on a selective use-disuse of memory systems mechanism are described in relation to mild cognitive impairment and dementia. Alternative speech perception and WM models are evaluated, and recent developments and generalisations, ELU model tests, and boundaries are discussed.

    Fulltekst (pdf)
    fulltext
  • 50.
    Signoret, Carine
    et al.
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Andin, Josefine
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Johnsrude, Ingrid
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Brain and Mind Institute, National Centre for Audiology, School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.
    Rudner, Mary
    Linköpings universitet, Institutet för handikappvetenskap (IHV). Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Cumulative effects of prior knowledge and semantic coherence during speech perception: an fMRI study2015Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    Semantic coherence and prior knowledge enhance perceptual clarity of degraded speech. Recent study by our team has shown that these two effects interact such that the perceptual clarity of noise-vocoded speech (NVS) is still enhanced by semantic coherence when prior knowledge is available from text cues and prior knowledge enhances perceptual clarity of NVS even when semantic coherence is low (Signoret et al., 2015). Here, we investigated the neural correlates of this interaction. We predicted 1) an effect of matching cues for both sentences with high and low semantic coherence in left-lateralized perisylvian areas (Zekveld et al., 2012) and right superior temporal gyrus (Wild et al., 2012), but stronger for low than for high coherent sentences since more resources are required to process sentences with low semantic coherence in the left inferior frontal gyrus (Obleser and Kotz, 2010) and 2) an effect of semantic coherence in temporal and inferior frontal cortex (Lau et al., 2008). The additive effect of semantic coherence when matching cues were provided should be observed in the angular gyrus (Obleser and Kotz, 2010). Twenty participants (age; M=25.14, SD=5.01) listened to sentences and performed an unrelated attentional task during sparse-imaging fMRI. The sentences had high or low semantic coherence, and were either clear, degraded (6-band NV) or unintelligible (1-band NV). Each spoken word was preceded (200 ms) by either a matching cue or a consonant string. Preliminary results revealed significant main effects of Cue (F(1,228) = 21.26; p < .05 FWE) in the left precentral gyrus, the left inferior frontal gyrus and the left middle temporal gyrus confirming the results of Zekveld et al (2012), but neither the main effect of Coherence nor the interaction between Cue and Coherence survived FWE correction. In accordance with our predictions, contrasts revealed a greater effect of matching cues for low than for high coherent sentences (t(19) = 6.25; p < .05 FWE) in the left superior temporal gyrus as well as left inferior frontal gyrus (BA 44 and 45), suggesting greater involvement of both top-down and bottom-up processing mechanisms during integration of prior knowledge with the auditory signal when sentence coherence is lower. There was a marginally greater effect of semantic coherence (t(19) = 3.58; p < .001unc) even when matching cues were provided in the left angular gyrus, the left middle frontal gyrus and the right superior frontal gyrus, suggesting greater involvement of top-down activation of semantic concepts, executive processes and the phonological store during integration of prior knowledge with the auditory signal when the semantic content of the speech is more readily available.

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