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  • 1.
    Bylund, Bengt
    et al.
    Västerviks sjukhus.
    Cervin, Torsten
    Finnström, Orvar
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences.
    Gäddlin, Per-Olof
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences.
    Leijon, Ingemar
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences.
    Mård, Selina
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Educational Sciences.
    Samuelsson, Stefan
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Educational Sciences.
    Sandstedt, Per
    Wärngård, Olof
    Very low birth weight children at 9 years:  School performance and behaviour in relation to risk factors2000In: Prenatal and Neonatal Medicine, ISSN 1359-8635, E-ISSN 1473-0774, Vol. 5, no 2, p. 124-133Article in journal (Refereed)
    Abstract [en]

    Objectives To investigate the school performance and behavior of very low-birth-weight children in comparison with controls, and relate the findings to risk factors.

    Methods All children with birth weight below 1501 g (VLBW) and normal birth weight (NBW) controls, born in the south-east region of Sweden during a 15-month period in 1987-88, were enrolled in a prospective follow-up study; 81 % (n = 70) and 82% (n = 72), respectively, were re-examined at the age of 9 years regarding growth, neurological status, neurofunctional classification and academic achievement tests (Raven's matrices, mathematics, vocabulary, reading ability). The need for special education at school was assessed and four behavioral problem scores were also assessed (hyperactivity, fine motor skills, gross motor skills, social skills). Children with known handicaps were not re-examined.

    Results VLBW children were shorter and lighter than controls, and differed from them with regard to neurological functional classification. As a group, they produced poorer results in all academic achievement tests except vocabulary, and also in two out of four behavioral subscales (hyperactivity and fine motor skills). When the comparison was restricted to children with normal Raven scores, almost all the differences disappeared. VLBW children had more reading difficulties but were less often than expected defined as dyslexic compared to NEW children.

  • 2.
    Finnström, Orvar
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Bylund, Bengt
    Västerviks sjukhus.
    Cervin, Torsten
    Centralsjukhuset i Kalmar.
    Gäddlin, Per-Olof
    Linköping University, Department of Molecular and Clinical Medicine.
    Leijon, Ingemar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Mård, Selina
    Linköping University, Department of Behavioural Sciences.
    Samuelsson, Stefan
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Sandstedt, Per
    hälsouniversitetet i Linköping.
    Wärngård, Olof
    Norrköpings sjukhus.
    Mycket lågviktiga barn vid 9 års ålder. De flesta klarar sig bra men barn med skolsvårigheter är överrepresenterade2000In: Svenska läkartidningen, ISSN 0371-439X, Vol. 97, p. 3492-3498Article in journal (Refereed)
  • 3.
    Gäddlin, Per-Olof
    et al.
    Linköping University, Department of Molecular and Clinical Medicine.
    Leijon, Ingemar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Mård, Selina
    Linköping University, Department of Behavioural Sciences.
    Samuelsson, Stefan
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Very low birthweight children at 9 and 12 years: School performance, behaviour and self-image2003In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 14Article in journal (Refereed)
  • 4.
    Karlsson, Thomas
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Mårdh, Selina
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Marcusson, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Geriatric. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Geriatric Medicine.
    Emotion and recollective experience in Alzheimer’s diseaseManuscript (preprint) (Other academic)
    Abstract [en]

    Emotional changes are common in Alzheimer’s disease (AD). In addition, damage to brain regions involved in emotion is abundant in AD. Although these finding imply that emotion memory is severely compromised in AD, absolute or relative sparing of emotional memory has occasionally been reported. Hence, we wanted to clarify how well AD patients can remember emotion words. Eighteen AD patients and fifteen healthy older persons participated in the experiment. Participants studied neutral, positive, and negative words. Implicit and explicit memory was assessed in two tasks: a word-fragment completion task and a recognition task, respectively. In the latter task, participants were asked to provide recollective judgments when they indicated that they recognized a word from previous study. Results indicated that AD patients responded to valence, and in particular negative valence, similar to controls, that AD patients evidenced severe deficits as to recollective experience, and that implicit memory remained intact in AD.

  • 5.
    Mårdh, Selina
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Cognitive erosion and its implications in Alzheimer’s disease2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of the present thesis was twofold, first to map the semantic memory decline in Alzheimer patients over time, second to take the patient’s perspective and create a multifaceted picture of the individual with Alzheimer’s disease through the study of memory, awareness, central coherence and emotions. Further issues concerned how Alzheimer individuals handled their cognitive erosion in everyday life and if they were well calibrated with their spouse in disease related matters.

    Two studies were performed, the first involved a longitudinal study of sematic deterioration, the second had a mixed methods design involving both quantitative and qualitative measures as in neuropsychological assessment and interviews.

    Through the longitudinal study it could be concluded that the nature of semantic deterioration is best described as loss of memory information rather than problems in accessing the information. It was further concluded that semantic concepts gradually lose their specific features during course of illness.

    The results from the second study revealed that the Alzheimer individuals were aware of their disease although they could not foresee the implications of their cognitive shortcomings in their everyday life. They evidenced weak central coherence, in that they were unable to infer details into a meaningful whole. This implies that they perceive their surrounding world in a fragmented way as consisting of separate objects rather than a comprehensible context. Concerning emotions it was found that they responded to negatively valenced words in the same way as normal ageing individuals, although being impaired in their response to positively and neutral words. Finally, the Alzheimer individuals and their spouses were not well calibrated regarding disease related issues.

    The findings of the present thesis have important clinical implications and gives valuable input to the understanding of the individual with Alzheimer’s disease.

    List of papers
    1. A longitudinal study of semantic memory impairment in patients with Alzheimer’s disease
    Open this publication in new window or tab >>A longitudinal study of semantic memory impairment in patients with Alzheimer’s disease
    2013 (English)In: Cortex, ISSN 0010-9452, E-ISSN 1973-8102, Vol. 49, no 2, p. 528-533Article in journal (Refereed) Published
    Abstract [en]

    Introduction

    The present study explored the nature of the semantic deterioration normally displayed in the course of Alzheimer’s disease (AD). The aim was to disentangle the extent to which semantic memory problems in patients with AD are best characterized as loss of semantic knowledge rather than difficulties in accessing semantic knowledge.

    Method

    A longitudinal approach was applied. The same semantic tests as well as same items were used across three test occasions a year apart. Twelve Alzheimer patients and 20 matched control subjects, out of a total of 25 cases in each group, remained at the final test occasion.

    Results and Conclusions

    Alzheimer patients were impaired in all the semantic tasks as compared to the matched comparison group. A progressing deterioration was evident during the study period. Our findings suggest that semantic impairment is mainly due to loss of information rather than problems in accessing semantic information.

    Place, publisher, year, edition, pages
    Elsevier, 2013
    Keywords
    Alzheimer’s disease; Semantic memory impairment; Longitudinal study
    National Category
    Psychology
    Identifiers
    urn:nbn:se:liu:diva-89593 (URN)10.1016/j.cortex.2012.02.004 (DOI)000316926800016 ()22445445 (PubMedID)
    Available from: 2013-02-27 Created: 2013-02-27 Last updated: 2017-12-06Bibliographically approved
    2. Aspects of awareness in patients with Alzheimer's disease
    Open this publication in new window or tab >>Aspects of awareness in patients with Alzheimer's disease
    2013 (English)In: International psychogeriatrics, ISSN 1041-6102, E-ISSN 1741-203X, Vol. 25, no 7, p. 1167-1179Article in journal (Refereed) Published
    Abstract [en]

    Background: The purpose of the present study was to gain insight into Alzheimer's disease (AD) patients' perception of the world through the study of a few aspects of awareness. The aspects in focus of the study were disease awareness, metacognition, managing of everyday life, and as a complement, the agreement (calibration) between patients and their spouses on the studied aspects was considered.

    Method: A mixed-method evaluation design was used involving 15 AD patients, their spouses, and 15 elderly healthy control subjects. The study comprised both a semistructured interview (AD patients and spouse) and a neuropsychological assessment (AD patients and control subjects).

    Results: The patients were aware of their disease and able to report on their illness. Despite this awareness, they were unable to realize and manage the practical and cognitive implications of their impairment. The results also indicate that patients and spouses were not well calibrated regarding thoughts about the disease and problems in handling the cognitive deterioration.

    Conclusions: The findings of our study have relevance to patients' well being and how they manage everyday life. An open dialogue on these issues between spouses and in the care for AD patients would hopefully enhance quality of life for all parties involved.

    Place, publisher, year, edition, pages
    Cambridge University Press, 2013
    Keywords
    Alzheimer's disease; awareness; metacognition; patients’ experiences; mixed methods
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-91884 (URN)10.1017/S1041610212002335 (DOI)000321262200014 ()23425334 (PubMedID)
    Available from: 2013-05-03 Created: 2013-05-03 Last updated: 2017-12-06Bibliographically approved
    3. Weak central coherence in patients with Alzheimer’s disease
    Open this publication in new window or tab >>Weak central coherence in patients with Alzheimer’s disease
    2013 (English)In: Neural Regeneration Research, ISSN 1673-5374, E-ISSN 1876-7958, Vol. 8, no 8Article in journal (Refereed) Published
    Abstract [en]

    Central coherence refers to the ability to interpret details of information into a whole. To date, the concept of central coherence is mainly used in research of autism, Asperger’s syndrome and recently in the research on eating disorders. The main purpose of the present study was to examine central coherence in patients with Alzheimer’s disease. Nine Alzheimer’s disease patients and ten age- and gender-matched control subjects, who differed significantly in neurological assessment, were shown a picture of a fire. Compared to control subjects, the Alzheimer’s disease patients described the picture in a fragmented way by mentioning details and separate objects without perceiving the context of the fire. In conclusion, patients with Alzheimer’s disease are at the weak end of central coherence, and hence suffer from a fragmented view of their surroundings. The findings have important clinical implications for the understanding of patients with Alzheimer’s diseaseand also for the possibility of caregivers to meet the Alzheimer’s disease individual in an appropriate way in the everyday care.

    Keywords
    Neural regeneration; neurodegenerative diseases; clinical practice; Alzheimer’s disease; senile dementia; central coherence; cognition; perception; information processing; neuroregeneration
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-91887 (URN)10.3969/j.issn.1673-5374.2013.08.011 (DOI)000317029900011 ()
    Available from: 2013-05-03 Created: 2013-05-03 Last updated: 2017-12-06Bibliographically approved
    4. Emotion and recollective experience in Alzheimer’s disease
    Open this publication in new window or tab >>Emotion and recollective experience in Alzheimer’s disease
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Emotional changes are common in Alzheimer’s disease (AD). In addition, damage to brain regions involved in emotion is abundant in AD. Although these finding imply that emotion memory is severely compromised in AD, absolute or relative sparing of emotional memory has occasionally been reported. Hence, we wanted to clarify how well AD patients can remember emotion words. Eighteen AD patients and fifteen healthy older persons participated in the experiment. Participants studied neutral, positive, and negative words. Implicit and explicit memory was assessed in two tasks: a word-fragment completion task and a recognition task, respectively. In the latter task, participants were asked to provide recollective judgments when they indicated that they recognized a word from previous study. Results indicated that AD patients responded to valence, and in particular negative valence, similar to controls, that AD patients evidenced severe deficits as to recollective experience, and that implicit memory remained intact in AD.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-91889 (URN)
    Available from: 2013-05-03 Created: 2013-05-03 Last updated: 2013-05-05Bibliographically approved
  • 6.
    Mårdh, Selina
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Arts and Sciences.
    Weak central coherence in patients with Alzheimer’s disease2013In: Neural Regeneration Research, ISSN 1673-5374, E-ISSN 1876-7958, Vol. 8, no 8Article in journal (Refereed)
    Abstract [en]

    Central coherence refers to the ability to interpret details of information into a whole. To date, the concept of central coherence is mainly used in research of autism, Asperger’s syndrome and recently in the research on eating disorders. The main purpose of the present study was to examine central coherence in patients with Alzheimer’s disease. Nine Alzheimer’s disease patients and ten age- and gender-matched control subjects, who differed significantly in neurological assessment, were shown a picture of a fire. Compared to control subjects, the Alzheimer’s disease patients described the picture in a fragmented way by mentioning details and separate objects without perceiving the context of the fire. In conclusion, patients with Alzheimer’s disease are at the weak end of central coherence, and hence suffer from a fragmented view of their surroundings. The findings have important clinical implications for the understanding of patients with Alzheimer’s diseaseand also for the possibility of caregivers to meet the Alzheimer’s disease individual in an appropriate way in the everyday care.

  • 7.
    Samuelsson, Stefan
    et al.
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Bylund, Bengt
    Västerviks sjukhus.
    Cervin, Torsten
    Centralsjukhuset i Kalmar.
    Finnström, Orvar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Gäddlin, Per-Olof
    Linköping University, Department of Molecular and Clinical Medicine.
    Leijon, Ingemar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Mård, Selina
    Linköping University, Department of Behavioural Sciences.
    Rönnberg, Jerker
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences, The Swedish Institute for Disability Research.
    Sandstedt, Per
    Hälsouniversitetet i Linköping.
    Wärngård, Olof
    Norrköpings sjukhus.
    The prevalence of reading disabilities among very low birth weight children at nine years of age - Dyslexics or poor readers?1999In: Dyslexia-An International Journal of Research and Practíce, Vol. 5, p. 94-112Article in journal (Refereed)
  • 8.
    Samuelsson, Stefan
    et al.
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Finnström, Orvar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    Leijon, Ingemar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    Mård, Selina
    Linköping University, Department of Behavioural Sciences.
    Phonological and surface profiles of reading difficulties among very low birth weight children: Comverging evidence for the developmental lag hypothesis2000In: Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading, ISSN 1088-8438, Vol. 4, p. 197-217Article in journal (Refereed)
1 - 8 of 8
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