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  • 1. Albertsson Wikland, K
    et al.
    Alm, F
    Aronsson, S
    Gustafsson, J
    Hagenäs, L
    Häger, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
    Ivarsson, S
    Kriström, B
    Marcus, C
    Moell, C
    Nilsson, KO
    Ritzén, M
    Tuvemo, T
    Westergren, U
    Westphal, O
    Åman, J
    Effect of growth hormone (GH) during puberty in GH-deficient children: preliminary results from an ongoing randomized trial with different dose regimens. 1999In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 428, p. 80-84Article in journal (Other (popular science, discussion, etc.))
  • 2. Kriström, B
    et al.
    Marcus, C
    Moell, C
    Nilsson, KO
    Tuvemo, T
    Westphal, O
    Albertsson Wikland, K
    Åman, J
    Ivarsson, SA
    Carlsson, A
    Bredberg, A
    Alm, J
    Aronsson, S
    Gustafsson, J
    Hagenäs, L
    Häger, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
    Prevalence of coeliac disease in Turner syndrome. 1999In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 88, p. 933-936Article in journal (Other (popular science, discussion, etc.))
  • 3.
    Timpka, Toomas
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Department of Health and Society, Division of Preventive and Social Medicine and Public Health Science. Östergötlands Läns Landsting, Centre for Public Health Sciences, Centre for Public Health Sciences.
    Angbratt, Marianne
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.
    Hermansson, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    Bolme, P
    Häger, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    Valter, L
    A high-precision protocol for identification of preschool children at risk for persisting obesity2007In: PLoS ONE, ISSN 1932-6203, Vol. 2, no 6Article in journal (Refereed)
    Abstract [en]

    Background: Recent studies suggest that adolescent adiposity is established already in preadolescence. Earlier studies have confirmed a strong tracking of obesity from adolescence to adulthood. Our aim was to examine the diagnostic accuracy of a population-derived protocol for identification of preschool children at risk for obesity in preadolescence. Methodology/Principal Findings: We analysed data obtained for child health surveillance up to age 5 from 5778 children born in a swedish county in 1991. The basic data set included age, sex, and weight and height measurements from the regular checkups between ages 1.5 and 5. Data not routinely collected in the child health centre setting were disregarded. The children were at age 10 randomly assigned to protocol derivation and validation cohorts and assessed for obesity according to IOTF criteria. The accuracy of predicting obesity in the validation cohort was measured using decision precision, specificity, and sensitivity. The decision protocol selected 1.4% of preschool children as being at obesity risk. The precision of the protocol at age 10 was 82% for girls and 80% for boys, and the specificity was 100% for both boys and girls, The sensitivity was higher for girls (41 %) than for boys (21%). The relative risk for obesity at age 10 estimated by the odds ratio for individuals selected by the protocol compared to non-selected peers was 212.6 (95% confidence interval 56.6 to 798.4) for girls and 120.3 (95% Cl 24.5 to 589.91for boys. Conclusion/Significance: A simple and inexpensive decision protocol based on BMI values proved to have high precision and specificity for identification of preschool children at risk for obesity persisting into adolescence, while the sersitivity was low especially for boys. Implementation and further evaluations of the protocol in chlid health centre settings are warranted. © 2007 Timpka et al.

  • 4. Tuvemo, T
    et al.
    Gustafsson, J
    Proos, LA
    Häger, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
    Growth hormone treatment during suppression of early puberty in adopted girls. 1999In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 88, p. 928-932Article in journal (Other (popular science, discussion, etc.))
  • 5.
    Tuvemo, Torsten
    et al.
    Kvinnors och barns hälsa Uppsala.
    Jonsson, B
    Kvinnors och barns hälsa Uppsala.
    Gustafsson, J
    Kvinnors och barns hälsa Uppsala.
    Albertsson-Wikland, Kerstin
    Sahlgrenska sjukhuset Göteborg.
    Aronson, AS
    Sahlgrenska sjukhuset Göteborg.
    Häger, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Ivarsson, Sten
    Barnkliniken Malmö.
    Kriström, B
    Barnkliniken Malmö.
    Marcus, Claude
    Huddinge sjukhus Huddinge.
    Nilsson, KO
    Barnkliniken Malmö.
    Westgren, U
    Sahlgrenska sjukhuset Göteborg.
    Westphal, Otto
    Sahlgrenska sjukhuset Göteborg.
    Åman, Jan
    Barnkliniken Örebro.
    Proos, LA
    Kvinnors och barns hälsa Uppsala.
    Final height after combined growth hormone and GnRH analogue treatment in adopted girls with early puberty2004In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 93, no 11, p. 1456-1462Article in journal (Refereed)
    Abstract [en]

    Background: Girls adopted from developing countries often have early or precocious puberty, requiring treatment with gonadotrophin-releasing hormone (GnRH) analogues. During such treatment, decreased growth velocity is frequent. Aim: To study whether the addition of growth hormone (GH) to GnRH analogue treatment improves final height in girls with early or precocious puberty. Methods: Forty-six girls with early or precocious puberty (age ≤9.5 y) adopted from developing countries were randomized for treatment for 2-4 y with GnRH analogue, or with a combination of GH and GnRH analogue. Results: During treatment, the mean growth velocity in the GH/GnRH analogue group was significantly higher compared to the control group. Combined GH/GnRH analogue treatment resulted in a higher final height: 158.9 cm compared to 155.8 cm in the GnRH analogue-treated group. Three out of 24 girls (13%) in the combined group and nine of the 22 girls (41%) treated with GnRH analogue alone attained a final height below -2 standard deviation scores (SDS). Conclusion: The difference between the two groups is statistically significant, and possibly of clinical importance. A future challenge is to identify a subgroup with clinically significant advantage of GH addition to GnRH analogue treatment. Being very short on arrival in Sweden and being short and young at start of treatment are possible indicators.

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