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  • 1. Narfström, K
    et al.
    Wrigstad, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL/MH.
    Clinical, electrophysiological and morphological changes in a case of hereditary retinal degeneration in the Papillon dog.1999In: Veterinary Ophthalmology, ISSN 1463-5216, E-ISSN 1463-5224, Vol. 2, p. 67-74Article in journal (Refereed)
  • 2. Narfström, Kristina
    et al.
    Wrigstad, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL.
    Ekesten, B
    Berg, A-L
    Neuronal ceroid lipofuscinosis: Clinical and morphologic findings in nine affected Polish Owczarek Nizinny (PON) dogs2007In: Veterinary Ophthalmology, ISSN 1463-5216, E-ISSN 1463-5224, Vol. 10, no 2, p. 111-120Article in journal (Refereed)
    Abstract [en]

    Objective: The aim of this study was to characterize the clinical and morphologic features of neuronal ceroid lipofuscinosis (NCL) in the Polish Owczarek Nizinny (PON) breed of dog. Animals: Nine Swedish PON dogs of both sexes were included in the study. Procedure: All dogs underwent a detailed clinical evaluation, with emphasis on ophthalmic exams. Histopathology and electron microscopy were performed on the eyes, brain and various internal organs. Immunohistochemical staining for detection of sphingolipid activator proteins (SAPs) and mitochondrial ATP synthase (SCMAS) was performed on the eyes and brain. Results: The dogs showed behavioral abnormalities, motor disturbances and visual impairment or blindness. Pupillary responses were abnormal while fundus changes varied from normal to severe retinal atrophy. Electroretinography (ERG) showed variable changes, from slight alterations in the process of dark adaptation to severely reduced or nonrecordable ERG a- and b-wave amplitudes. Histopathology revealed intracytoplasmic storage bodies within neurons of the brain and in retinal cells, especially the retinal pigment epithelium (RPE). Round to oval granular type of inclusion bodies, known as granular osmiophilic dense deposits (GRODS), were found in neuronal cells in the brain and in the retina. Immunohistochemistry identified the storage material in the brain and retina as consisting of SAPs. Conclusion: The presently described NCL disease in PON dogs shows similarities to previously recorded cases in the Miniature Schnauzer. The closest human equivalent to this disease is infantile NCL (CLN1), in which the major stored proteins are SAPs and the ultrastructure of the inclusion bodies of neuronal cells is granular. © 2007 American College of Veterinary Ophthalmologists.

  • 3.
    Wrigstad, Anders
    Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Linköping University, Faculty of Health Sciences.
    Hereditary dystrophy of the retina and the retinal pigment epithelium in a strain of Briard dogs: A clinical, morphological and electrophysiological study1994Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A congenital hereditary retinal dystrophy was found in a Swedish strain of Briard dogs. A test breeding scheme produced a total of 6 litters of Briard dogs and Briard/Beagle crosses. A recessive mode of inheritance with a varying expression was observed. Visual impairment was evident at the first examination at 5 weeks to 10 months of age although the fundi of affected animals appeared normal, as seen by ophthalmoscopy. Nyctalopia was present in all dogs. Day vision was normal or nearly normal in the first litter. The other affected dogs showed severe visual impairment or blindness in daylight. During a 6-year follow-up, it was not possible to detect any decrease in visual ability. Low amplitude or non-recordable ERGs were diagnostic at the time of first examination, and onwards.

    Electron microscopy showed disorientation of rod outer segments at 5 weeks of age. In older dogs, degeneration of photoreceptors was observed. This finding was most prominent in the peripheral parts. The rods were most severely affected. At late stages, severe changes were observed in the inner retina. Large electron-lucent inclusions accumulated in the RPE cells, mainly in the central parts, becoming more numerous and spreading towards the periphery with increasing age.

    On DC ERG recordings, a high amplitude, negative, slow potential wasfound at the site of the c-wave. This negative potential may reflect a loss of the positive PI originating in the RPE. The functional changes correlated to the morphologic changes in the photoreceptors and pigment epithelial cells. The results show many similarities to congenital amaurosis in man and the presently described strain of Briard dogs may become an animal model of human visual cell disease.

  • 4.
    Wrigstad, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL.
    Algvere, Peep
    Arteriovenous adventitial sheathotomy for branch retinal vein occlusion: Report of a case with longterm follow-up2006In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 84, no 5, p. 699-702Article in journal (Refereed)
    Abstract [en]

    Purpose: To report the longterm follow-up of a case of branch retinal vein occlusion (BRVO) treated with vitrectomy and adventitial sheathotomy. Methods: A three-port vitrectomy was performed in a 55-year-old man with symptoms of BRVO of about 3months' duration. After a core vitrectomy, the adventitial sheath of the affected arteriovenous crossing was dissected so that the anterior surface of the arteriole was freely exposed. Results: On the second postoperative day, visual acuity (VA) in the affected left eye had increased from preoperative 0.3 to 0.6. Within 6months the fundus had almost normalized and vision improved to 1.0. Cataract surgery was performed about 2years after the vitrectomy. At a follow-up 4years and 11months after the sheathotomy, VA was 1.0 and no signs of recurrence were seen. Conclusions: Adventitial sheathotomy may improve vision in selected cases of BRVO. Further studies are necessary to determine the role of sheathotomy in the management of cases with BRVO. © 2006 Acta Ophthalmol Scand.

  • 5.
    Wrigstad, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL.
    Hanitzsch, Renate
    Pigment epithelial changes in a strain of pigmented rabbits with low ERG b-wave amplitudes2004In: Vision Research, ISSN 0042-6989, E-ISSN 1878-5646, Vol. 44, no 1, p. 99-102Article in journal (Refereed)
    Abstract [en]

    Retinas from a strain of rabbits with low dark-adapted electroretinographic (ERG) b-wave amplitudes, and declining ERG responses with time, were examined by light and electron microscopy. Seven rabbits from the affected strain (13 months to 5 years old) and six control animals (6-26 months old) were included in the study. Small inclusions with an electron dense border, about 0.2-1.5 μm in diameter, were significantly (p<0.01) more numerous within the retinal pigment epithelial (RPE) cells in the affected rabbits than in the control animals. No morphological evidence of retinal degeneration was found. Further studies are needed to establish the functional defect in this strain of rabbits.

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