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  • 1.
    Aschan, Gunnar
    et al.
    Linköpings universitet.
    Bunnfors, Irja
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Experimentella studier över industriellt använda lösningsmedels toxicitet på balanssinnet i centrala nervsystemet1979Rapport (Övrigt vetenskapligt)
  • 2.
    Aschan, Gunnar
    et al.
    Linköpings universitet.
    Bunnfors, Irja
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Experimentella studier över industriellt använda lösningsmedels toxicitet på balanssinnet i centrala nervsystemet1982Rapport (Övrigt vetenskapligt)
  • 3.
    Aschan, Gunnar
    et al.
    Linköpings universitet. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Bunnfors, Irja
    Linköpings universitet. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköpings universitet. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköpings universitet. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköpings universitet. Departments of Otolaryngology and Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Xylene exposure. Electronystagmografic and gaschromatografic studies in rabbit1977Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 84, nr 1-6, s. 370-376Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Complaints of vertigo from people who are exposed to industrial solvents have focused interest on their toxic effect on the nervous system. In order to evaluate the influence of an organic solvent, xylene, on the mammalian vestibular system, a series of rabbit experiments were performed. To achieve a constant concentration, the xylene was infused as a lipid emulsion. Blood concentrations were estimated by gas chromatography. Elec-tronystagmography in darkness revealed that at blood xylene concentrations of 30 ppm all rabbits had a positional nystagmus. The beat direction was the opposite of positional alcohol nystagmus. Another difference between the alcohol and the xylene reaction was that rotatory nystagmus responses were exaggerated. The relations between the present findings and the reactions and blood concentrations in people exposed to industrial solvents are discussed.

  • 4.
    Aschan, Gunnar
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Lösningsmedels toxicitet på balanssinnet i centrala nervsystemet. Experimentella studier på kanin1979Rapport (Övrigt vetenskapligt)
  • 5.
    Aschan, Gunnar
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Tham, Richard
    Linköpings universitet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Påverkan av vestibularissystemet i en djurexperimentell modell1977Ingår i: Svensk Otolaryngol förening, ISSN 0280-7939, Vol. 1, nr 2, s. 1-4Artikel i tidskrift (Övrigt vetenskapligt)
  • 6.
    Bergenius, Johan
    et al.
    Karolinska Institutet.
    Hydén, Dag
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Möller, Claes
    Linköpings universitet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Frenzels brillor eller datoriserad otoneurologi1990Konferensbidrag (Övrigt vetenskapligt)
  • 7. Gejrot, Tomas
    et al.
    Hydén, Dag
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Apropå otologins profiler2002Ingår i: Svensk ÖNH tidskrift, ISSN 1400-0121, Vol. 9, s. 17-17Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 8.
    Hydén, Dag
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Bror Hjort bejakade livet trots stort hörselhandikapp efter tuberkulos i ungdomen2003Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 100, s. 2304-2306Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 9.
    Hydén, Dag
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Is Borrelia antibody testing motivated in the routine investigation of patients with acute audio- (and/or) vestibular loss?2000Ingår i: Equilibrium research, clinical equilibriometry and modern treatment : transactions of the XXth regular meeting of the Bárány Society,1998, Amsterdam: Elsevier , 2000, s. 429-Konferensbidrag (Refereegranskat)
  • 10.
    Hydén, Dag
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Kirurgisk behandling av livshotande infektioner vardagsarbete för öronläkarna på Key-Åbergs tid2006Ingår i: Smittnytt : information från smittskyddet och mikrobiologen, Vol. 41Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 11.
    Hydén, Dag
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Oto-Rhino-Laryngologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Arlinger, Stig
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Oto-Rhino-Laryngologi. Linköpings universitet, Hälsouniversitetet.
    On light-induced sneezing2009Ingår i: EYE, ISSN 0950-222X, Vol. 23, nr 11, s. 2112-2114Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose To investigate whether the tickling inside the nose before a light-induced sneeze in susceptible individuals is correlated to a recordable local activity or not. Methods Seven healthy volunteers, three with a history of light-induced sneezing, were stimulated with stroboscopic light or a strong halogen lamp. Recording was done with an evoked potential averaging technique via intranasal electrodes placed in such a way that they substantially reduced the strong electrical response from the retina. Results Despite an adequate light stimulus, no reproducible electrical activity could be recorded from any of the members in any experiment. Conclusion Light-induced sneezing is presumably a central phenomenon. The electrical activity travels through the optic pathways straight to the trigeminal nucleus and the tickling is a referred sensation. A genetic variation in the distance between the optic pathways (colliculus superior) and the mesencephalic part of the trigeminal nucleus may explain why light-induced sneezing is more common in certain families and races.

  • 12.
    Hydén, Dag
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Arlinger, Stig
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Teknisk audiologi.
    On the sneeze-reflex and its control2007Ingår i: Rhinology, ISSN 0300-0729, E-ISSN 1996-8604, Vol. 45, nr 3, s. 218-219Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Experiments in cats have shown that sneezing can be induced using low intensity electrical current. This study focusses on answering the question whether the sneezing-reflex can also be induced in man through electrical stimulation, whether it is reproducible, and if the response can be abolished pharmacologically? Three healthy males were tested using intranasal stimulation in different parts of the nose using a current from an electric pulse generator. Using currents in the range 2-11 mA, it was possible to induce and reproduce sneezing in the anterior portion of the nose corresponding to the distribution area of the anterior ethmoidal nerve. In one tested subject, local anaesthetics applied to the mucous membranes of the nose abolished the sneezing. Sneeze reflex-reduction may be one way to reduce viral contamination between subjects. Further research could include pharmacological investigations to identify a sneeze-inhibiting substance with small risks for side effects that can be added to common cold nasal sprays.

  • 13.
    Hydén, Dag
    et al.
    Östergötlands Läns Landsting.
    Fransson, Sven-Göran
    Östergötlands Läns Landsting.
    Tablettutlöst temporär sväljningsrubbning: [Temporary swallowing disorder caused by tablets]1987Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 84, nr 7, s. 461-462Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    [No abstract available]

  • 14.
    Hydén, Dag
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Gejrot, Tomas
    Hans Key-Åberg - Linköpings förste öronklinikchef, militärläkare och författare med intressant släkthistoria. Operatör i Lennart Nilssons första medicinska fotoreportage2005Ingår i: Svensk medicinhistorisk tidskrift, ISSN 1402-9871, Vol. 9, s. 115-120Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [sv]

       

  • 15.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    The VOR frequency and velocity dependence1991Ingår i: Vestibular Diagnosis and Neuro-Otosurgical Management of the Skull Base / [ed] Claes Toni Haid, Demeter Verlag , 1991, s. 64-66Konferensbidrag (Övrigt vetenskapligt)
  • 16.
    Hydén, Dag
    et al.
    Linköpings universitet. Department of Otolaryngology, Linköping University, Sweden.
    Larsby, Birgitta
    Linköpings universitet. Department of Otolaryngology, Linköping University, Sweden.
    Velocity dependence of the vestibulo-ocular reflex over a broad frequency range1991Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 111, nr s481, s. 293-294Artikel i tidskrift (Refereegranskat)
  • 17.
    Hydén, Dag
    et al.
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden).
    Larsby, Birgitta
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden).
    Schwartz, D. W. F.
    University of Toronto, Ontario, Canada.
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden).
    Quantification of slow compensatory eye movements in patients with bilateral vestibular loss: A Study with a Broad Frequency-band Rotatory Test1983Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 96, nr 3-4, s. 199-206Artikel i tidskrift (Refereegranskat)
  • 18.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Thell, Jan
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköpings universitet.
    Rotatory test results in patients with acoustic tumours before and after surgery1987Ingår i: / [ed] Pirodda E, Pompeiano O., 1987, s. 118-118Konferensbidrag (Övrigt vetenskapligt)
  • 19.
    Hydén, Dag
    et al.
    Linköpings universitet. Department of Otalaryngology, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköpings universitet. Department of Otalaryngology, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Otalaryngology, Linköping University, Linköping, Sweden.
    Broad frequency rotatory testing1988Ingår i: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 105, nr s455, s. 48-52Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The method of broad-frequency-band rotatory testing with results from normal subjects and patients with peripheral uni- and bilateral loss as well as central vestibular disorders are reviewed. The following conclusions are drawn: adequate testing of the vestibulo-ocular reflex including side detection of unilateral loss in light or in darkness can only be done with either random or high-frequency (2.5–3 Hz) sinusoidal stimulation. Measurements of compensatory eye movements at lower frequencies where vestibular and non-vestibular signals interact are of interest for central vestibular diagnosis. A decreased ability to suppress vestibular nystagmus is not an uncommon finding in patients with large acoustic neuromas or pathology in the brainstem or cerebellum.

  • 20.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Clinical value of the broad spectrum rotatory test1995Ingår i: NES,1995;10, 1995, s. 303-309Konferensbidrag (Övrigt vetenskapligt)
  • 21.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Klinisk applikation av ett bredfrekvent rotationstest1982Ingår i: Sv Otolaryngol förening 1982;2, 1982Konferensbidrag (Övrigt vetenskapligt)
  • 22.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Objective measurement of vestibular compensation1993Ingår i: NES, 1993, 1993Konferensbidrag (Övrigt vetenskapligt)
  • 23.
    Hydén, Dag
    et al.
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Quantification of compensatory eye movements in light and darkness1984Ingår i: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 96, nr s406, s. 209-211Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A broad frequency-band rotatory test has been used to quantify compensatory eye movements in 13 healthy subjects during light and darkness conditions. Eye movements were recorded by EOG. Head movements were recorded either by a potentiometer attached to the chair's axis of rotation or by an angular rate sensor attached to a bite-board. Gain and phase values between eye and head velocity were calculated. A systematic error in the higher frequency range is introduced in the results by assuming head movement equal to chair movement. Different instructions in the dark can alter the gain values at lower frequencies (up to 2 Hz) during sinusoidal stimulation. During pseudorandom stimulation no such differences can be obtained. During all test conditions with the rate sensor the gain values approach unity at about 3 Hz.

     

  • 24.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    The oscillatory test in patient with bilateral vestibular loss1982Ingår i: Nordic symposium on data processing of eye movements, 1982, s. 21-22Konferensbidrag (Övrigt vetenskapligt)
  • 25.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Visual suppression tests in diagnosis of of diseases of the central nervous system1983Ingår i: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 30, s. 205-209Artikel i tidskrift (Refereegranskat)
  • 26.
    Hydén, Dag
    et al.
    Linköpings universitet. Department of Otolaryngology, Linköping University, Sweden.
    Larsby, Birgitta
    Linköpings universitet. Department of Otolaryngology, Linköping University, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology, Linköping University, Sweden.
    Möller, Claes
    Östergötlands Läns Landsting. Department of Otolaryngology, Linköping University, Sweden.
    Visual suppression tests in acoustic neuroma patients1989Ingår i: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 108, nr s468, s. 349-351Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Fifty-five patients with a unilateral acoustic neuroma were investigated preoperatively with visual suppression tests during rotatory oscillation and caloric irrigation. During a sinusoidal oscillation, 29% of the patients showed a reduced suppression compared to 9% during pseudo-random oscillation and 11% in the caloric test. In the sinusoidal and caloric tests the majority of the patients with deficient suppression had large or medium-sized tumors. In a few patients with small tumors, pathology was observed in both sinusoidal and randomized tests, presumably as a sign of unconcentration. The study shows that the sinusoidal visual suppression test and to a lesser degree suppression during caloric irrigation are of value for identification of brainstem-cerebellum compression of acoustic neuromas.

  • 27.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköpings universitet.
    Visual Suppression Tests in Aucustic Neuroma Patients1988Konferensbidrag (Övrigt vetenskapligt)
  • 28.
    Hydén, Dag
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Tham, Richard
    Linköpings universitet.
    Impairment of visuo-vestibular interaction in humans exposed to toluene1983Ingår i: Journal for Oto-Rhino-Laryngology, Head and Neck Surgery, ISSN 0301-1569, Vol. 45, nr 5, s. 262-269Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    15 healthy volunteers were investigated in a vestibulo-oculomotor test battery during toluene exposure. The concentration was comparable to the threshold limit value. The results were compared to an identical air experiment. The intoxication caused an impaired visual suppression during a pseudo-random oscillatory swing test and also an increased saccade speed. Other vestibular-oculomotor parameters were normal. The findings are in accordance with our earlier study on styrene in humans, showing that the visual suppression test and the saccade test are sensitive parameters assessing neurotoxic influences by organic solvents.

  • 29.
    Hydén, Dag
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Latkovic, Stefan
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oftalmologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Ögonkliniken US/LiM.
    Brunk, Ulf
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Patologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk patologi och klinisk genetik.
    Laurent, Claude
    Ear involvement in ligneous conjunctivitis: A rarity or an under-diagnosed condition?2002Ingår i: Journal of Laryngology and Otology, ISSN 0022-2151, E-ISSN 1748-5460, Vol. 116, nr 6, s. 482-487Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Conjunctivitis lignosa, a rare affliction of the conjunctiva, is sometimes associated with other disturbances. We present two children with concurrent conjunctivitis lignosa and ear involvement. In these two cases, there were histopathologically verified ligneous changes of the middle ears. Routine haematoxylin and eosin, van Gieson, periodic acid-Schiff (PAS) and alcian blue staining of specimens from the eyes and middle ears revealed findings typical for ligneous conjunctivitis. In addition, new histochemical and immunohistochemical studies for glycosaminoglycans on specimens from the eyes and middle ears showed that the accumulations of the amorphous, cell-deficient material stained strongly but heterogeneously for hyaluronic acid and weakly but uniformly for keratin sulphate. The staining for other glycosaminoglycans, e.g. chondroitin-4-sulphate and dermatan sulphate was confined to vessels and areas rich in collagen fibres and fibroblasts. In patients with conjunctivitis lignosa, the ear involvement may remain undiagnosed due to its resemblance to secretory otitis media with effusion. Since isolated ear involvement may occur, we advocate biopsies for routine haematoxylin and eosin, and specific staining for hyaluronic acid and keratin sulphate, also in children with protracted, refractory otitis media with atypical effusion.

  • 30.
    Hydén, Dag
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Roberg, Magnus
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Östergötlands Läns Landsting, Medicincentrum, Infektionskliniken i Östergötland.
    Diagnostiken både enkel och svår vid Ramsay Hunts syndrom. Virusangreppet mer omfattande än man tidigare trott.2000Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 97, s. 1114-1120Artikel i tidskrift (Övrigt vetenskapligt)
  • 31.
    Hydén, Dag
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Åkerlind, Britt
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Klinisk mikrobiologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk mikrobiologi.
    Peebo, Markus
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Inner ear and facial nerve complications of acute otitis media with focus on bacteriology and virology2006Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 126, nr 5, s. 460-466Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Conclusion. Among 20 patients with inner ear complications and/or peripheral facial palsy secondary to acute otitis media (AOM) a proven or probable bacteriological cause was found in 13 (65%). In seven patients (35%), a proven or probable viral cause was found. Only two of the patients (10%), with a proven bacterial AOM and a clinical picture of a purulent labyrinthitis in both, together with a facial palsy in one, had a substantial degree of dysfunction. Although the number of patients in this study is relatively low our findings show that inner ear complications and facial palsy due to AOM can be of both bacterial and viral origin. Severe sequelae were found only where a bacterial origin was proven. Objectives. Inner ear complications and/or peripheral facial palsy secondary to AOM are rare. The general understanding is that they are due to bacterial infections. However, in some of these patients there are no clinical or laboratory signs of bacterial infections and they have negative bacterial cultures. During recent years different viruses have been isolated from the middle ear or serologically proven in AOM patients and are thought to play a pathogenetic role. We suggest that in some cases of AOM complications from the inner ear and the facial nerve can be caused by viruses. The purpose of our study was to analyze infectious agents present in patients with inner ear complications and/or facial palsy arising from AOM. Patients and methods. The medical records of 20 patients who had inner ear complications and/or facial palsy following AOM (unilateral in 18, bilateral in 2) between January 1989 and March 2003 were evaluated. Bacterial cultures were carried out for all patients. Sera from 12 of the patients were stored and tested for a battery of specific viral antibodies. In three patients, investigated between November 2002 and March 2003, viral cultures were also performed on samples from the middle ear and nasopharynx. Results. Nineteen patients had inner ear symptoms. Eight of them had a unilateral sensorineural hearing loss and vertigo, three had vertigo as an isolated symptom and one, with bilateral AOM, had bilateral sensorineural hearing loss. Seven patients had a combination of facial palsy and inner ear symptoms (unilateral sensorineural hearing loss in three, unilateral sensorineural hearing loss and vertigo in two, bilateral sensorineural hearing loss and vertigo in one, with bilateral AOM, and vertigo alone in one). One patient had an isolated facial palsy. Healing was complete in 11 of the 20 patients. In seven patients a minor defect remained at follow-up (a sensorineural hearing loss at higher frequencies in all). Only two patients had obvious defects (a pronounced hearing loss in combination with a moderate to severe facial palsy (House-Brackman grade 4) in one, distinct vestibular symptoms and a total caloric loss in combination with a high-frequency loss in the other. Eight patients had positive bacteriological cultures from middle ear contents: Streptococcus pneumoniae in two, beta-hemolytic Streptococcus group A in two, beta-hemolytic Streptococcus group A together with Staphylococcus aureus in one, Staph. aureus alone in one and coagulase-negative staphylococci (interpreted as pathogens) in two. In the 12 patients with negative cultures, there was a probable bacteriological cause due to the outcome in SR/CRP and leukocyte count in five. In four patients serological testing showed a concomitant viral infection that was interpreted to be the cause (varicella zoster virus in two, herpes simplex virus in one and adenovirus in one.) In three there was a probable viral cause despite negative viral antibody test due to normal outcome in SR/CRP, normal leukocyte count, serous fluid at myringotomy and a relatively short pre-complication antibiotic treatment period. © 2006 Taylor & Francis.

  • 32.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    A broad frequency oscillatory test1982Ingår i: Nordic symposium on data processing of eye movements, 1982, s. 19-Konferensbidrag (Övrigt vetenskapligt)
  • 33.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    A computerized broad spectrum rotatory test1983Ingår i: Proc NES 1983, 1983, s. 266-272Konferensbidrag (Övrigt vetenskapligt)
  • 34.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Ett bredfrekvent rotationstest1982Ingår i: Sv Otolaryngol förening 1982;2, 1982, s. 2-Konferensbidrag (Övrigt vetenskapligt)
  • 35.
    Larsby, Birgitta
    et al.
    Linköpings universitet. Department of Oto-Rhino-Laryngology, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköpings universitet. Department of Oto-Rhino-Laryngology, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Oto-Rhino-Laryngology, Linköping University, Linköping, Sweden.
    Gain and phase characteristics of compensatory eye movements in light and darkness: A study with a broad frequency-band rotatory test1984Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 97, nr 3-4, s. 223-232Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Thirteen normal subjects were investigated with a broad frequency-band (up to 4.5 Hz) rotatory test. The vestibular stimulation consisted of either a pseudo-random or a sinusoidal frequency sweep oscillation. Eye movements were recorded by EOG. Head movements were recorded either by a potentiometer attached to the chairs axis of rotation or by an angular rate sensor attached to a biteboard. Gain and phase values between eye and head movements were calculated. Measurements were performed in light and darkness during the execution of various fixation tasks. In the higher frequency range there was a difference in gain and phase between potentiometer and rate sensor measurements due to movement of the head relative to the headholder. Visual suppression, in agreement with earlier studies, was more effective during a sinusoidal stimulation than during a pseudorandom stimulation at low frequencies, using the more precise rate sensor measurement technique. Different instructions in the dark could alter the gain values at lower frequencies (up to 2 Hz) during sinusoidal stimulation. During pseudo-random stimulation no such differences could be elicited. Under all test conditions with the rate sensor, the gain values approached unity at about 3 Hz.

  • 36.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Rotationstest i vestibulär diagnostik1983Ingår i: Sv Otolaryngol förening ,1:83, 1983, s. 76-77Konferensbidrag (Övrigt vetenskapligt)
  • 37.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Persson, P.
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköpings universitet.
    Caloric and rotatory tests in patients with uni-and bilateral vestibular loss1984Ingår i: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, Vol. 97, nr 412, s. 111-112Artikel i tidskrift (Refereegranskat)
  • 38.
    Larsby, Birgitta
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Möller, Claes
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Smooth pursuit in normals and patients with acoustic neuromas1987Ingår i: The Vestibular system: Neurophysiologic and clinical research / [ed] Malcolm D. Graham, John L. Kemink, New York: Raven Press , 1987, s. 293-296Konferensbidrag (Refereegranskat)
  • 39.
    Larsby, Birgitta
    et al.
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Tham, Richard
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Eriksson, Birgitta
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Hydén, Dag
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Liedgren, Christer
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Bunnfors, Irja
    Linköpings universitet. Department of Otolaryngology, University Hospital, Linköping, Sweden.
    Effects of Trichloroethylene on the human vestibulo-oculomotor system1986Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 101, nr 3-4, s. 193-199Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Ten healthy volunteers were subjected to a vestibulo-oculomotor test battery before, during and 1 hour after trichloroethylene exposure. The concentration of trichloroethylene in in-spiratory air was 32–78 ppm (176429 mg/m3). The concentration of trichloroethylene in venous blood was followed throughout the experiment. The mean pulmonary uptake was estimated. Each test person was also subjected to a control experiment, breathing air free of trichloroethylene. A decreased ability to visually suppress the vestibulo-oculomotor reflex during sinusoidal stimulation was noticed during trichloroethylene exposure. One hour after exposure the test subjects showed a decreased maximum velocity of the voluntary saccade and a decreased ability to follow a sinusoidally moving target.

     

  • 40.
    Larsby, Birgitta
    et al.
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Bunnfors, Irja
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Exposure of rabbits to styrene. Electronystagmographic findings correlated to the styrene level in blood and cerebrospinal fluid1978Ingår i: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 4, nr 1, s. 60-65Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective methods for critically evaluating the toxic effect of industrial solvents are highly desirable. As many of these solvents are suspected to cause vertigo, an animal experimental model was set up for studying the effects of solvents on the vestibular systems. The vestibular function was studied by registration of involuntary eye movements--nystagmus--which are elicited via central vestibulo-oculomotor connections. During exposure to styrene a so-called positional nystagmus was demonstrated that indicated vestibular disturbances. Nystagmus is normally elicited by rotatory acceleration. During exposure to styrene the direction of this rotatory nystagmus was reversed. The incidence of the positional nystagmus correlated well with the blood level of the solvent, measured by gas chromatography. Kinetic studies also demonstrated a rapid equilibration between the level of the solvent in arterial blood and cerebrospinal fluid, and therefore suggested that estimation of the arterial level reliably indicates the level in the central nervous system.

  • 41.
    Larsby, Birgitta
    et al.
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Tham, Richard
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Norlander, Björn
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Hydén, Dag
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Aschan, Gunnar
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Rubin, A.
    Linköpings universitet. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    Exposure of rabbits to methylchloroform. Vestibulardisturbances correlated to blood and cerebrospinal fluid levels1978Ingår i: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 41, nr 1, s. 7-15Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A previously described experimental model for studying the effects on the central nervous system of rabbits, specifically the vestibular apparatus, has been applied to methylchloroform. To achieve a steady concentration the solvent was infused as a lipid emulsion. The blood and cerebrospinal fluid kinetics have been studied. The arterial blood level seems to be closely correlated to the concentration in the central nervous tissue. Vestibular function has been studied by recording the involuntary eye movements — nystagmus — which are elicited via central vestibulo-oculomotor connections. At blood levels of methylchloroform above 75 ppm a so called “positional nystagmus”, indicated vestibular disturbances, is demonstrated. The relationship between the present findings in rabbits and the reaction and blood concentrations in people exposed to industrial solvents, are discussed.

  • 42.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Thell, Jan
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Change in vestibular-oculomotor function due to transdermally applied scopolamine1985Ingår i: In: Myers E, editor.; 1985  Elsevier SiencePublishers B.V., 1985, s. 297-298Konferensbidrag (Övrigt vetenskapligt)
  • 43.
    Larsby, Birgitta
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Teknisk audiologi. Linköpings universitet, Hälsouniversitetet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköpings universitet.
    Eriksson, Birgitta
    Linköpings universitet.
    Tham, Richard
    Linköpings universitet.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Optokinetic disturbances caused by styrene. An experimental study in rabbit1995Ingår i: NES, 1995;8, 1995, s. 433-441Konferensbidrag (Övrigt vetenskapligt)
  • 44.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköpings universitet.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Disturbances of the vestibular system by toxic agents1976Ingår i: 15. Scandinavian Congress of Physiology and Pharmacology, Århus 1976: Abstracts of Invited Lectures, Symposia and Free Communications, Fysiologisk Institut, Aarhus Universitet , 1976, s. 157-157Konferensbidrag (Övrigt vetenskapligt)
  • 45.
    Larsby, Birgitta
    et al.
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Tham, Richard
    Linköpings universitet.
    Rubin, Allan
    University of Toronto, Canada.
    Aschan, Gunnar
    Linköpings universitet.
    Industriella lösningsmedels inverkan på balansapparaten1977Ingår i: Svensk Otolaryngol förening, ISSN 0280-7939, Vol. 1, s. 43-44Artikel i tidskrift (Övrigt vetenskapligt)
  • 46.
    Möller, Claes
    et al.
    Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Ödkvist, Lars
    Linköpings universitet.
    Thell, Jan
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Vestibular and audiologic functions in Gentamicin-treated Menier's disease1988Ingår i: The American journal of otology, ISSN 0192-9763, Vol. 9, nr 5, s. 383-391Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Fifteen patients with disabling Meniere's disease were treated with local intratym-panic administration of gentamicin once daily. They had suffered from frequent attacks of vertigo and vomiting, the hearing in the affected ears was decreased permanently, and spontaneous nystagmus was observed. The number of treatment days ranged between 3 and 11. Follow-up time was 1 to 6 years. For evaluation of the treatment, audiologic and vestibular examinations were used, including the broad frequency-band rotatory test (0.4-4.5 Hz). Fourteen patients were free from vertigo after treatment. In 5 patients, there was an increased hearing loss, and in 10 it remained unchanged. Tinnitus and fullness sensations were diminished. After treatment, all ears were unresponsive to caloric stimulation. The clinical examination and rotatory testing in light with sinusoidal stimulation revealed good central compensation of the vestibular loss. However, with pseudorandomized oscillations in darkness, the broad frequency-band rotatory test quantified the loss of peripheral vestibular function and was able to detect the side of the lesion in eight of nine patients.

  • 47.
    Möller, Claes
    et al.
    Östergötlands Läns Landsting. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköpings universitet. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Thell, Jan
    Östergötlands Läns Landsting. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköpings universitet. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Hydén, Dag
    Linköpings universitet. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Bergholtz, Lars
    Östergötlands Läns Landsting. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Otoneurological findings in psycho-organic syndrome caused by industrial solvent exposure1989Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 107, nr 1-2, s. 5-12Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Nine subjects with long-term (8-30 years) occupational exposure to industrial solvents and a confirmed diagnosis of psycho-organic syndrome (POS) have been studied with audiological and otoneurological test batteries. The results were compared to a matched control group of nine industrial workers not exposed to solvents and to normal data from healthy volunteers. In the clinical examination, the Romberg test identified 5/9 workers as pathologic and concurrently the stabilometry showed significantly larger sway areas in the POS-group. In the audiological test battery, the significantly pathologic tests were discrimination of interrupted speech and evoked cortical responses to frequency glides (CRA-delta-f). The saccade test disclosed abnormal findings in 5/9 workers. In the smooth pursuit test, abnormality was found at some test frequencies using pseudorandomized stimulus. The VOR-suppression test was significantly abnormal at all test frequencies. The test battery used strongly indicates CNS lesions due to industrial solvents.

  • 48. Rask-Andersen, Helge
    et al.
    Friberg, Ulla
    Bagger-Sjöbäck, Dan
    Hessén-Söderman, Ann-Charlotte
    Bergenius, Johan
    Idrizbegovic, Esma
    Granath, Anna
    Hergils, Leif
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Hydén, Dag
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
    Johansson, Marianne
    Stjernschantz, Johan
    Randomized, Double-Blind, Placebo-Controlled, Dose-Titration Study with Latanoprost Salt in Meniere´s Disease2006Ingår i: Association for research in otolaryngology,2006, 2006, s. 331-331Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

       

  • 49. Samuelsson, A-K
    et al.
    Hydén, Dag
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Oto-Rhino-Laryngologi. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Roberg, Magnus
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Östergötlands Läns Landsting, Medicincentrum, Infektionskliniken i Östergötland.
    Skogh, Thomas
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Reumatologi. Östergötlands Läns Landsting, Medicincentrum, Länskliniken för Reumatologi i Östergötland.
    Evaluation of anti-hsp70 antibody screening in sudden deafness2003Ingår i: Ear and Hearing, ISSN 0196-0202, E-ISSN 1538-4667, Vol. 24, nr 3, s. 233-235Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: To assess the diagnostic utility of anti-hsp70 antibody screening in sudden deafness. Design: Sera from 27 patients with sudden deafness and 100 healthy blood donors were analyzed by Western blotting (WB) for the presence of antibodies against 68 kD heat shock protein (anti-hsp70). Results: 19% of the patient sera and 14% of the control sera turned out positive, which was not significantly different. Conclusions: The anti-hsp70 WB test lacks clinical utility for diagnostic screening in patients with sudden deafness.

  • 50.
    Tham, Richard
    et al.
    Linköpings universitet.
    Larsby, Birgitta
    Linköpings universitet.
    Hydén, Dag
    Linköpings universitet.
    Aschan, Gunnar
    Linköpings universitet.
    Ödkvist, Lars
    Linköpings universitet.
    Pharmacokinetics of solvents in the experimental animal modell1977Ingår i: International symposium on the control of air pollution in the working environment, 1977, 1977, s. 92-98Konferensbidrag (Övrigt vetenskapligt)
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