liu.seSearch for publications in DiVA
Change search
Refine search result
1 - 16 of 16
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Central Pain2005In: The paths of pain 1975-2005 / [ed] Harold Merskey, John D. Loeser, Ronald Dubner, Seattle: IASP , 2005, p. 45-45Chapter in book (Other academic)
    Abstract [en]

    The Paths of Pain celebrates 30 years of pain research and management by the world's leading basic scientists and clinicians in the field. Combining history and science, it provides an unrivalled, authoritative selection of chapters that examine the problems and achievements in the topic. It looks at the way pain has been understood, investigated, and treated from before the foundation of the IASP up to the present time.The achievements of this period include the development and refinement of the gate control theory of pain in physiology, as well as enormous strides in the identification of cellular and molecular mechanisms of pain, a better appreciation of the psychological aspects of pain, the evolution of more effective analgesics, coordinated comprehensive pain clinics, acute pain services, and the improved definition of painful illnesses. The reader has the opportunity to explore a book by many hands in which the description of the advances is often provided by those who achieved them.

  • 2.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Central Pain2005In: Fibromyalgia and Other Central Pain Syndromes / [ed] Daniel J Wallace, Daniel J Clauw, Seattle: IASP Press , 2005, 1, p. 1057-1074Chapter in book (Other academic)
    Abstract [en]

    This volume is the first comprehensive text devoted to fibromyalgia and other centrally mediated chronic pain syndromes. Leading experts examine the latest research findings on these syndromes and present evidence-based reviews of current controversies. Chapters discuss the definition, epidemiology, and pathophysiology of chronic pain and fibromyalgia, the clinical presentations of fibromyalgia syndrome, and central sensitization syndromes associated with chronic neuromuscular pain. The contributors thoroughly examine various approaches to evaluation and management of patients with fibromyalgia and chronic pain. Other chapters focus on disability issues, prognosis, and future research directions. A critically reviewed listing of Websites and other resources is included.

  • 3.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Central pain2003In: Handbook of Pain Management / [ed] Ronald Melzack OC FRSC PhD ,(Patrick D. Wall FRS DM FRCP, Linköping: Linköpings universitet , 2003, 1, p. 305-327Chapter in book (Other academic)
    Abstract [en]

    An Essentials version of the Textbook of Pain, 4/e, this book is intended to provide the pain medicine specialist and trainee with an easy-to-access overview on the management complexities, assessment tools and multiple treatment modalities that are currently available to the physician dealing with the full spectrum of pain syndromes. The emphasis throughout is on the clinical aspects of pain medicine. It will contain the core information that the practitioner and trainee needs. Each chapter is brief and succinctly written and the text is well broken up with headings, tables and summary charts. The book is divided into 2 main sections; clinical states (acute, chronic and cancer pain) and therapeutic aspects ( pharmacological, surgical, physiotherapy, psychotherapy ) and it presents a rational, multidisciplinary approach to the management of pain.

  • 4.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Neurology . Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Central pain and the role of quantitative sensory testing (QST) in research and diagnosis2003In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 7, no 4, p. 339-343Conference paper (Other academic)
    Abstract [en]

    [No abstract available]

  • 5.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Neurogen smärta2003In: Smärta och smärtbehandling / [ed] Mads Werner och Peter Strang, Linköping: Linköpings universitet , 2003, 1, p. 454-477Chapter in book (Other academic)
    Abstract [sv]

    Smärta och smärtbehandling är en heltäckande grundbok. Den beskriver smärta i vid bemärkelse: smärtfysiologi, smärtanalys, problem vid speciella diagnoser, psykologiska aspekter och mycket annat. Denna nya genomarbetade upplaga spänner över både fysiologisk nociception och det komplexa smärtlidandet och hur detta yttrar sig i ett beteendeperspektiv. I tillägg innehåller Smärta och smärtbehandling ett avsnitt om forskning kring nya läkemedel, och ett extensivt kapitel om farmakologi.Boken ger användbara kliniska exempel genom ett stort antal fallbeskrivningar.Smärta och smärtbehandling är till lika delar fördjupningslitteratur och ett värdefullt uppslagsverk. Den vänder sig till läkare och annan personal inom sjukvården: sjuksköterskor, sjukgymnaster, arbetsterapeuter, kuratorer med flera som kommer i kontakt med smärtpatienter. Den har även en given plats inom utbildningen av dessa grupper. Bokens författare är alla kända experter inom sina områden.

  • 6.
    Boivie, Jörgen
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Casey, Kenneth I
    Central Pain in the Face and Head2005In: Fibromyalgia and other central pain syndromes / [ed] Daniel J. Wallace, Daniel J. Clauw, Lippincott Williams & Wilkins , 2005, 1, p. -432Chapter in book (Other academic)
    Abstract [en]

    This volume is the first comprehensive text devoted to fibromyalgia and other centrally mediated chronic pain syndromes. Leading experts examine the latest research findings on these syndromes and present evidence-based reviews of current controversies.

    Chapters discuss the definition, epidemiology, and pathophysiology of chronic pain and fibromyalgia, the clinical presentations of fibromyalgia syndrome, and central sensitization syndromes associated with chronic neuromuscular pain. The contributors thoroughly examine various approaches to evaluation and management of patients with fibromyalgia and chronic pain. Other chapters focus on disability issues, prognosis, and future research directions. A critically reviewed listing of Websites and other resources is included.

  • 7.
    Fridriksson, Steen
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Hillman, Jan
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Landtblom, Anne-Marie
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Boive, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Education of referring doctors about sudden onset headache in subarachnoid hemorrhage2001In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 103, no 4, p. 238-242Article in journal (Refereed)
    Abstract [en]

    Objectives – Forty percent of patients with aneurysmal subarachnoid hemorrhage have prodromal warning episodes and difficulties in identifying these events are repeatedly documented. Modifications of diagnostic and referral patterns through educational programs of local doctors may help to identify such patients before a major devastating rupture occurs.

    Materials and methods– A teaching program about sudden onset headache, targeting referring doctors, was systematically applied and its impact on early misdiagnosis of ruptured aneurysms was prospectively studied.

    Results– Forty percent of all studied patients experienced a warning episode, manifested as apoplectic headache, prior to hospitalization. An initial diagnostic error was evident in 12% of the patients. Diagnostic errors were reduced by 77% as a result of continuous interaction between neurosurgeons and local physicians.

    Conclusion– Misdiagnosed warning episodes cause greater loss of lives and higher morbidity on a population basis than does delayed ischemic complications from vasospasm in aneurysmal SAH. Teaching programs focused on local physicians have a profound impact on outcome at low cost.

  • 8.
    Gerdle, Björn
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Rehabilitation Medicine. Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Johansson, Eva
    Umeå Universitet.
    Inledning2006In: Metoder för behandling av långvarig smärta - en systematisk litteraturöversikt / [ed] Statens beredning för medicinsk utvärdering, Stockholm: Statens beredning för medicinsk utvärdering (SBU) , 2006, 2, p. 47-107Chapter in book (Other academic)
    Abstract [sv]

      

    Syftet med rapporten är att sammanfatta det vetenskapliga underlaget rörande effekter, biverkningar samt kostnadseffektivitet för metoder som används för att behandla långvarig, icke-cancerrelaterad smärta. Behandling som innebär öppen kirurgi har exkluderats från genomgången.

  • 9.
    Gordh, T.E.
    et al.
    Multidisciplinary Pain Center, Uppsala University Hospital, S-751 85 Uppsala, Sweden.
    Stubhaug, A.
    Department of Anaesthesiology, University of Oslo, Rikshospitalet University Hospital, 0027 Oslo, Norway.
    Jensen, T.S.
    Department of Neurology, Danish Pain Research Centre, Aarhus University Hospital, Aarhus, 8000, Denmark.
    Arner, S.
    Arnèr, S., Pain Clinic, Department of Anaesthesiology, Karolinska University Hospital, Solna, S-171 76 Stockholm, Sweden.
    Biber, B.
    Department of Anaestesiology, Umeå University Hospital, S-901 85 Umeå, Sweden.
    Boivie, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Neurology . Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Mannheimer, C.
    Multidisciplinary Pain Center, Department of Medicine, Sahlgrenska University Hospital, Östra, 41685 Göteborg, Sweden.
    Kalliomaki, J.
    Kalliomäki, J., Department of Rehabilitation, Lund University Hospital, S-221 85 Lund, Sweden.
    Kalso, E.
    Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Haartmaninkatu 2A, 00029 HUS, Finland.
    Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, multi-center study2008In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 138, no 2, p. 255-266Article in journal (Refereed)
    Abstract [en]

    A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses up to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period. The primary efficacy variable was the change in the mean pain intensity score from baseline to the last week of treatment. Other variables included pain relief, health related quality of life (SF-36), interference of sleep by pain, Clinician and Patient Global Impression of Change, and adverse effects. Nine centers randomized a total of 120 patients, 22 of whom withdrew. There was no statistically significant difference between the treatments for the primary outcome efficacy variable. However, gabapentin provided significantly better pain relief (p = 0.015) compared with placebo. More patients had at least a 30% pain reduction with gabapentin compared with placebo (p = 0.040) and pain interfered significantly less with sleep during gabapentin treatment compared with placebo (p = 0.0016). Both the Patient (p = 0.023) and Clinician (p = 0.037) Global Impression of Change indicated a better response with gabapentin compared with placebo. Gabapentin was well tolerated. The most common adverse effects were dizziness and tiredness. © 2007 International Association for the Study of Pain.

  • 10.
    Kalman, Sigga
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Svensson, H
    Lisander, Björn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Boive, Jörgen
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Quantitative sensory changes in humans after itravenous regional block with mepivacaine.1999In: Regional anesthesia, ISSN 0146-521X, Vol. 24, p. 236-241Article in journal (Refereed)
  • 11.
    Kalman, Sigga
    et al.
    Linköping University, Department of Medicine and Care, Anaesthesiology. Linköping University, Faculty of Health Sciences.
    Österberg, Anders
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Sörensen, Jan
    Linköping University, Department of Medicine and Care, Anaesthesiology. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Bertler, Åke
    Linköping University, Department of Medicine and Care, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
    Morphine responsiveness in a group of well-defined multiple sclerosis patients: a study with i.v. morphine2002In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 6, no 1, p. 69-80Article in journal (Refereed)
    Abstract [en]

    Pain in multiple sclerosis (MS) is more common than has previously been believed. About 28% of all MS patients suffer from central pain (CP), a pain that is difficult to treat. In the present study we have investigated the responsiveness of this pain to morphine. Fourteen opioid-free patients (eight woman and six men) with constant, non-fluctuating, long-lasting CP caused by MS were investigated. Placebo (normal saline), morphine and naloxone were given intravenously in a standardized manner. The study design was non-randomized, single blind and placebo controlled. Ten patients experienced less than 50% pain reduction by placebo and less than 50% pain reduction by morphine. Four patients were opioid responders, i.e. had minimal or no effect on pain by placebo, >50% pain reduction after morphine and >25% pain increase after naloxone, given intravenously following morphine. However, this response was obtained after high doses of morphine (43 mg, 47 mg, 50 mg and 25 mg; mean 41 mg). Thus, compared with nociceptive pain, only a minority of the patients with CP due to MS responded to morphine and only at high doses. The present results are in accord with experimental studies indicating that neuropathic pain is poorly responsive but not totally unresponsive to opioids. The results do not support the routine use of strong opioids in MS patients with CP.

  • 12.
    Landtblom, Anne-Marie
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Fridriksson, Steen
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Hillman, Jan
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Johansson, Gunn
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Johansson, Ingegerd
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Åskknallshuvudvärk: oftast ett godartat tillstånd2006In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, no 37, p. 2632-2637Article in journal (Refereed)
    Abstract [en]

    We have performed a study of 137 consecutive patients with thunderclap headache (TCH), showing that a large majority of the patients do not have a subarachnoidal haemorrhage (SAH). It is concluded that 11% of all TCH is caused by SAH and that history and findings in the clinical neurological examination cannot discriminate safely between an SAH and a more benign cause. All patients should be investigated with a CT scan and an analyses of the cerebrospinal fluid to exclude a SAH if the CT scan did not show an SAH. The 10-year follow-up showed that none of the patients with TH without SAH had a cerebral haemorrhage of any kind. Pathological results on CT and CSF examinations were found in 14 of the patients with non-SAH TCH, including five with cerebral infarction, three with intracerebral haemorrhage, four with aseptic meningitis and one with venous sinus thrombosis.

  • 13.
    Landtblom, Anne-Marie
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Fridriksson, Steen
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Hillman, Jan
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Johansson, G.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Johansson, Ingegerd
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Sudden onset headache: a prospective study of features, incidence and causes2002In: Cephalalgia, ISSN 0333-1024, E-ISSN 1468-2982, Vol. 22, no 5, p. 354-360Article in journal (Refereed)
    Abstract [en]

    Sudden onset headache is a common condition that sometimes indicates a life- threatening subarachnoid haemorrhage (SAH) but is mostly harmless. We have performed a prospective study of 137 consecutive patients with this kind of headache (thunderclap headache = TCH). The examination included a CT scan, CSF examination and follow-up of patients with no SAH during the period between 2 days and 12 months after the headache attack. The incidence was 43 per 100 000 inhabitants > 18 years of age per year; 11.3% of the patients with TCH had SAH. Findings in other patients indicated cerebral infarction (five), intracerebral haematoma (three), aseptic meningitis (four), cerebral oedema (one) and sinus thrombosis (one). Thus no specific finding indicating the underlying cause of the TCH attack was found in the majority of the patients. A slightly increased prevalence of migraine was found in the non-SAH patients (28%). The attacks occurred in 11 cases (8%) during sexual activity and two of these had an SAH. Nausea, neck stiffness, occipital location and impaired consciousness were significantly more frequent with SAH but did not occur in all cases. Location in the temporal region and pressing headache quality were the only features that were more common in non-SAH patients. Recurrent attacks of TCH occurred in 24% of the non-SAH patients. No SAH occurred later in this group, nor in any of the other patients. It was concluded that attacks caused by a SAH cannot be distinguished from non-SAH attacks on clinical grounds. It is important that patients with their first TCH attack are investigated with CT and CSF examination to exclude SAH, meningitis or cerebral infarction. The results from this and previous studies indicate that it is not necessary to perform angiography in patients with a TCH attack, provided that no symptoms or signs indicate a possible brain lesion and a CT scan and CSF examination have not indicated SAH.

  • 14.
    Österberg, Anders
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Central pain in multiple sclerosis: a double-blind placebo-controlled trial of amitriptyline and carbamazepineManuscript (preprint) (Other academic)
    Abstract [en]

    Approximately 23% of all MS patients suffer from non-trigeminal, nonparoxysmal central pain (CP). This pain is generally considered difficult to treat effectively; tricyclic antidepressants, anti epileptic drugs or analgesics are most commonly used. In this study, the pain relieving effects of amitriptyline and carbamazepine were investigated.

    The design was a randomised double-blind, three-phase, crossover, placebo-controlled trial. Twenty-three patients with definitive MS entered the study (mean age 55 year, range 40-79 years), all had been thoroughly investigated in a project on CP in MS, and no one showed signs of depression. The treatment phases lasted four weeks, and were separated by a one-week washout. The final doses were 75 mg for amitriptyline and 600 mg for carbamazepine (adjusted from 800 mg, because of side-effects). The effect of treatment was assessed by two daily ratings of pain using a 10- step verbal rating scale (VRS), and at the end of each treatment period using a 5-step global rating scale. For the assessment of depression the Comprehensive Psychopathological Rating Scale (CPRS) was used.

    Originally 23 patients were included in the study, but due to side-effects 7 patients discontinued during the amitriptyline phase, and 12 during the carbamazepine phase. With carbamazepine this occurred at low doses (100-200 mg).

    The results show that amitriptyline significantly reduced non-paroxysmal CP in MS, compared to placebo (VRS 4.2 vs. 5.3; p<0.05) and according to the global rating; nine of 14 patients were responders (64%). The effect could already be seen during the second week of treatment. The plasma concentrations of amitriptyline and its active metabolite nortriptyline were higher in the responders (329 nmol/l) that in the non-responders (252 nmol/l, n.s). CPRS scores for depression were normal, and were not altered by the medication.

    Two of nine patients treated with carbamazepine reported some pain relief, but the effect did not reach significance when compared with placebo. No correlation was found between effect and plasma concentration.

    It is concluded that amitriptyline, but not carbamazepine, has a weak effect on non-paroxysmal CP in MS, and that MS patients appear to be particularly sensitive to the side-effects of the two drugs.

  • 15.
    Österberg, Anders
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences.
    Central pain in multiple sclerosis: sensory abnormalities2010In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 14, no 1, p. 104-110Article in journal (Refereed)
    Abstract [en]

    Many patients with multiple sclerosis (MS) develop central neuropathic pain (CP). In the present study somatosensory abnormalities have been analysed in detail in 62 patients with MS and CP (42 women, 20 men; mean age 52 years) and in a control group of 10 women and 6 men (mean age 47 years) with MS and sensory symptoms, but without pain.

    Assessment included clinical testing and quantitative methods (QST) for the measurement of perception thresholds for touch, vibration, and temperatures.

    All CP patients except two (97%) had abnormal thresholds for innoxious and/or noxious temperatures, compared to 81% in the control group (p < 0.05). There was a tendency towards the opposite regarding sensibility to touch, which was decreased in 66% vs. 87% (n.s.), vibration (55% vs. 81%; n.s.) and to joint movement (32% vs. 62%; p < 0.04).

    Comparisons between painful and non-painful regions showed both the absolute threshold values and the index values to be significantly more abnormal, in the CP regions, for warmth (p < 0.001), cold (p < 0.05), difference limen (innoxious warmth and cold, p < 0.01), cold pain (p < 0.01) and heat pain/cold pain combined (p < 0.001).

    Also the comparisons between regions with central pain and regions with sensory symptoms in the controls showed significantly more abnormal thresholds in the CP patients for warmth (p < 0.05), cold (p < 0.01), difference limen (innoxious warmth and cold, p < 0.01) and heat pain/cold pain combined (p < 0.001).

    The results support the general hypothesis that only patients who have lesions affecting the spinothalamo-cortical pathways run the risk of developing central pain.

  • 16.
    Österberg, Anders
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Thoumas, K-Å
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Central pain in multiple sclerosis: prevalence and clinical characteristics2005In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, no 5, p. 531-542Article in journal (Refereed)
    Abstract [en]

    Pain is more common in multiple sclerosis (MS) than has previously been recognised. In the present study we have investigated the occurrence of central pain (CP) in MS and defined its characteristics. Questionnaires were sent to all 429 patients with definite MS in the patient register at our neurology department. All admitting to pain were interviewed and offered an extended interview and examination. Three hundred and sixty four patients responded (86%), of whom 57.5% reported pain during the course of their disease (21% nociceptive, 2% peripheral neuropathic and 1% related to spasticity). One hundred patients (27.5%) had CP, including 18 patients (4.9%) with trigeminal neuralgia.

    The non-trigeminal CP was, in 87%, located in the lower and in 31% in the upper extremities. It was mostly bilateral (76%) and constant, with 88% experiencing daily pain. Only 2% had paroxysmal attacks. Aching, burning, pricking were the commonest qualities. The pain was intense with small to moderate spontaneous variation. In 5.5% of all patients (20% of the patients with CP), pain was a presenting symptom, alone or in combination with other symptoms.

    The most common neurological symptoms/signs besides CP were sensory abnormalities (98%, dominated by abnormal sensibility to painful stimulus and temperature). Trigeminal neuralgia in MS started later in life and after longer disease duration than non-trigeminal pain. Both types of CP existed either chronically or as a feature of relapse. Central pain is thus an important symptom in MS (around 30%) and causes much suffering.

1 - 16 of 16
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf