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  • 1.
    Ahlbeck, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Astma lathund: Astma hos vuxna2018Annet (Annet vitenskapelig)
    Abstract [sv]

    Åtta till tio procent av den vuxna befolkningen har astma. Av dessa har65 procent lindrig, 25 procent medelsvår och 10 procent svår astma.Astma är en heterogen sjukdom, där en kronisk luftvägsinflammationoftast föreligger.

    Sjukdomen kännetecknas av återkommande luftvägssymtom såsom pipi bröstet, andnöd, trånghetskänsla i bröstet och hosta som varierar övertiden tillsammans med en variabel luftvägsobstruktion.

  • 2.
    Ahlbeck, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US.
    Astmainhalator med återkopplingssystem gav bättre vård och sänkta kostnader [Asthma inhaler with feedback system provided better care and lower costs].2014Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 111, nr 5, s. 160-160Artikkel i tidsskrift (Annet vitenskapelig)
  • 3.
    Ahlbeck, Lars
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Ahlberg, Emelie
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Nyström Kronander, Ulla
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Björkander, Janne
    Futurum, Academy of Health and Care, Jönköping, Sweden.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Intralymphatic allergen immunotherapy against pollen allergy. A 3-year open follow-up study of 10 patients2018Inngår i: Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, E-ISSN 1534-4436, Vol. 121, nr 5, s. 626-627Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To date, allergen immunotherapy (AIT) is the only treatment that affects the long-term development of allergic rhinoconjunctivitis and induces clinical tolerance primarily by stimulating regulatory T (Treg) cells, attenuating T helper 2 (Th2) responses and synthesis of blocking antibodies1. Conventional AIT with subcutaneous injections, sublingual tablets or drops is effective, but consumes time and resources 2.

  • 4.
    Ahlbeck, Lars
    et al.
    Östergötlands Läns Landsting, Närsjukvården i västra Östergötland, Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland.
    Faresjö, Tomas
    Linköpings universitet, Institutionen för hälsa och samhälle, Allmänmedicin. Linköpings universitet, Hälsouniversitetet.
    Åkerlind, Ingemar
    Östergötlands Läns Landsting, Närsjukvården i västra Östergötland, Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland.
    Differences in patient perception of appropriate level of care1996Inngår i: European Journal of General Practice, Vol. 2, nr 3, s. 109-112Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The principle of achieving the most cost-effective level of care in relation to needs is an essential aim for all health care systems. However, it is not certain that the corresponding knowledge and attitudes with respect to the appropriate level of care for different symptoms can be found in the general population. There may be age-related differences in illness behaviour that manifest in ‘overutilisation’ of the system. We studied illness behaviour with regard to attitudes and inclination to seek care for different symptoms at various levels in the health care system.Methods: The study group consisted of a random selection of 296 persons, born in the 1940s, ′50s and ′60s, and living in a defined region in Sweden. In a questionnaire they had to choose between different levels of care for twelve symptom descriptions with varying degrees of severity. The answers were scored according to the level of care, adequacy and overutilisation.Results: The vast majority of participants chose an adequate level of care. However, overutilisation was found, particularly among women born in the 1960s and to some extent among men born in the 1940s. These two groups together constituted about 70% of all the individuals who tended to overutilise the health care in their expressed preferences.Conclusions: These individuals do not receive cost-effective care, or the most adequate care with regard to their needs. The results indicate, however, that the problem was more a question of attitude rather than a lack of knowledge and information.

  • 5.
    Løkke, Anders
    et al.
    Department of Respiratory Medicine, Aarhus County Hospital, Aarhus, Denmark.
    Ahlbeck, Lars
    Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Respiratory System Drug Committee at Region Östergötland, Linköping, Sweden.
    Bjermer, Leif
    Department of Respiratory Medicine and Allergology, Institute of Clinical Science, Lund University, Lund, Sweden.
    Mortensen, Jann
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Denmark;Department of Medicine, National Hospital, Torshavn, Faroe Islands.
    Østrem, Anders
    Gransdalen Health Care Centre, Oslo, Norway.
    Pasternack, Iris
    Summaryx Ltd, HTA Research, Helsinki, Finland.
    Safioti, Guilherme
    TEVA Pharmaceuticals, Helsingborg, Sweden.
    Torvinen, Saku
    TEVA Pharmaceuticals BV, Amsterdam, the Netherlands.
    Expert Nordic perspectives on the potential of novel inhalers to overcome unmet needs in the management of obstructive lung disease2015Inngår i: European clinical respiratory journal, ISSN 2001-8525, Vol. 2, s. 1-8, artikkel-id 29445Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The effective self-management of obstructive lung disease is dependent upon the patient achieving good inhaler technique. However, many current inhalers are complicated to use, which may lead to handling difficulties. These difficulties can cause clinically relevant errors, whereby pharmacotherapy fails to achieve adequate lung deposition and therapeutic effect. In this report, the potential of novel inhaler devices to overcome unmet needs in the management of obstructive lung disease is considered by a panel of Nordic experts. The panel concludes that innovative inhalers can contribute to good disease management and better use of healthcare resources.

  • 6.
    Nyström Kronander, Ulla
    et al.
    Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Ahlbeck, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Atopi, allergi och överkänslighet2018Inngår i: Läkemedelsboken, Läkemedelsverket , 2018Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 7.
    Nyström, Ulla
    et al.
    Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Ahlbeck, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Allergi och annan överkänslighet2018Inngår i: Internmedicin / [ed] Ulf Dahlström, Stergios Kechagias, Leif Stenke, Liber, 2018, 6, s. 31-58Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 8.
    Senti, Gabriela
    et al.
    Clinical Trials Center, University Hospital, Zurich, Switzerland.
    Freiburghaus, Andreas U.
    Clinical Trials Center, University Hospital, Zurich, Switzerland.
    Larenas-Linnemann, Désirée
    Hospital Médica Sur, Mexico City, Mexico.
    Hoffmann, Hans Jürgen
    Department of Clinical Medicine, Aarhus University, Denmark; Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Denmark.
    Patterson, Amber M.
    ENT & Allergy Specialists of Northwest Ohio, USA.
    Klimek, Ludger
    Center for Rhinology and Allergology, Germany.
    Di Bona, Danilo
    Department of Emergency and Organ Transplantation, Chair and School of Allergology and Clinical Immunology, University of Bari – Aldo Moro, Italy.
    Pfaar, Oliver
    Center for Rhinology and Allergology, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
    Ahlbeck, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Akdis, Mübeccel
    Swiss Institute of Allergy and Asthma Research SIAF, Switzerland.
    Weinfeld, Dan
    Asthma and Allergy Clinic (Adults), Department of Internal Medicine, South Alvsborgs (Central) Hospital, Sweden.
    Contreras-Verduzco, Francisco A.
    Allergy Department, National Institute of Pediatrics, Mexico.
    Pedroza-Melendez, Alvaro
    Allergy Department, National Institute of Pediatrics, Mexico.
    Skaarup, Søren H.
    Department of Clinical Medicine – Department of Respiratory Diseases and Allergy, Aarhus University, Denmark.
    Lee, Sang Min
    Division of Allergy and Pulmonology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Republic of Korea.
    Cardell, Lars-Olaf
    Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Sweden.
    Schmid, Johannes M.
    Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Denmark.
    Westin, Ulla
    Division of Ear, Nose and Throat Diseases, Head and Neck Surgery, Department of Clinical Sciences, Lund University, Skane University Hospital, Sweden; Region Skane, Skane University Hospital, Sweden.
    Dollner, Ralph
    Department Otorhinolaryngology – Head and Neck Surgery, Clinic for Head-Neck and Reconstructive Surgery, Oslo University Hospital (OUS) HF – Rikshospitalet, Oslo, Norway.
    Kündig, Thomas M.
    Department of Dermatology, University Hospital Zurich, Switzerland.
    Intralymphatic Immunotherapy: Update and Unmet Needs.2019Inngår i: International Archives of Allergy and Immunology, ISSN 1018-2438, E-ISSN 1423-0097, Vol. 178, nr 2, s. 141-149Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i.e., directly into lymph nodes - intralymphatic immunotherapy (ILIT). The major advantages of ILIT over the current AIT approaches are its short duration and the low allergen doses administered. The whole treatment consists of merely 3 ultrasound-guided injections into inguinal lymph nodes 1 month apart. While the number of patients included in randomised controlled trials is still limited, the clinical results for ILIT are encouraging, but more clinical trials are needed, as well as more preclinical work for optimising formulations.

  • 9.
    Stridh, Björn
    et al.
    Kista vårdcentral, Stockholm, Sweden.
    Romberg, K.
    Näsets Läkargrupp, Höllviken, Sweden; Kunskapscentrum för allergi, astma och KOL, Skånes universitetssjukhus, Lund, Sweden.
    Ställberg, Björn
    Institutionen för folkhälso- och vårdvetenskap, allmänmedicin och preventivmedicin, Uppsala universitet, Uppsala, Sweden.
    Ahlbeck, Lars
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Kiotseridis, Hampus
    Barnläkargruppen Sparta, Lund, Sweden; Institutionen för lungmedicin och allergologi, Lunds universitet, Lund, Sweden.
    Janson, Christer
    Institutionen för medicinska vetenskaper, Uppsala universitet, Uppsala, Sweden.
    Många överbehandlas med astmamedicin [When and how to step down asthma treatment]2018Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115Artikkel i tidsskrift (Fagfellevurdert)
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