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  • 1.
    Lang, Hauke
    et al.
    Univ Med Mainz, Germany.
    de Santibanes, Eduardo
    Italian Hosp Buenos Aires, Argentina.
    Schlitt, Hans J.
    Univ Regensburg, Germany.
    Malago, Massimo
    UCL, England.
    van Gulik, Thomas
    Univ Amsterdam, Netherlands.
    Machado, Marcel A.
    Univ Sao Paulo, Brazil.
    Jovine, Elio
    Maggiore Hosp, Italy.
    Heinrich, Stefan
    Univ Med Mainz, Germany.
    Ettorre, Giuseppe Maria
    Camillo Hosp, Italy.
    Chan, Albert
    Univ Hong Kong, Peoples R China.
    Hernandez-Alejandro, Roberto
    Univ Rochester, NY USA.
    Campos, Ricardo Robles
    Virgen de la Arrixaca Clin and Univ Hosp, Spain.
    Sandström, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Linecker, Michael
    Univ Hosp Zurich, Switzerland.
    Clavien, Pierre-Alain
    Univ Hosp Zurich, Switzerland.
    10th Anniversary of ALPPS-Lessons Learned and quo Vadis2019In: Annals of Surgery, ISSN 0003-4932, E-ISSN 1528-1140, Vol. 269, no 1, p. 114-119Article in journal (Refereed)
    Abstract [en]

    Objective: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications and clinical scenarios, leading to steady improvements in safety. This report presents the current status of ALPPS. Summary Background Data: ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety and oncologic benefits. Methods: During the 12th biennial congress of the European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th anniversary of ALPP" was held to discuss indications, management, mechanisms of regeneration, as well as pitfalls of this novel technique. The aim of the meeting was to make an inventory of what has been achieved and what remains unclear in ALPPS. Results: Precise knowledge of liver anatomy and its variations is paramount for success in ALPPS. Technical modifications, mainly less invasive approaches like partial, mini- or laparoscopic ALPPS, mostly aiming at minimizing the extensiveness of the first-stage procedure, are associated with improved safety. In fibrotic/cirrhotic livers the degree of future liver remnant hypertrophy after ALPPS appears some less than that in noncirrhotic. Recent data from the only prospective randomized controlled trial confirmed significant higher resection rates in ALPPS with similar peri-operative morbidity and mortality rates compared with conventional 2-stage hepatectomy including portal vein embolization. ALPPS is effective reliably even after failure of portal vein embolization. Conclusions: Although ALPPS is now an established 2-stage hepatectomy additional data are warranted to further refine indication and technical aspects. Long-term oncological outcome results are needed to establish the place of ALPPS in patients with initially nonresectable liver tumors.

  • 2.
    Xiong, Sixing
    et al.
    Huazhong Univ Sci and Technol, Peoples R China.
    Hu, Lin
    Huazhong Univ Sci and Technol, Peoples R China.
    Hu, Lu
    Huazhong Univ Sci and Technol, Peoples R China.
    Sun, Lulu
    Huazhong Univ Sci and Technol, Peoples R China.
    Qin, Fei
    Huazhong Univ Sci and Technol, Peoples R China.
    Liu, Xianjie
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
    Fahlman, Mats
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhou, Yinhua
    Huazhong Univ Sci and Technol, Peoples R China.
    12.5% Flexible Nonfullerene Solar Cells by Passivating the Chemical Interaction Between the Active Layer and Polymer Interfacial Layer2019In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 31, no 22, article id 1806616Article in journal (Refereed)
    Abstract [en]

    Nonfullerene (NF) organic solar cells (OSCs) have been attracting significant attention in the past several years. It is still challenging to achieve high-performance flexible NF OSCs. NF acceptors are chemically reactive and tend to react with the low-temperature-processed low-work-function (low-WF) interfacial layers, such as polyethylenimine ethoxylated (PEIE), which leads to the S shape in the current-density characteristics of the cells. In this work, the chemical interaction between the NF active layer and the polymer interfacial layer of PEIE is deactivated by increasing its protonation. The PEIE processed from aqueous solution shows more protonated N+ than that processed from isopropyl alcohol solution, observed from X-ray photoelectron spectroscopy. NF solar cells (active layer: PCE-10:IEICO-4F) with the protonated PEIE interfacial layer show an efficiency of 13.2%, which is higher than the reference cells with a ZnO interlayer (12.6%). More importantly, the protonated PEIE interfacial layer processed from aqueous solution does not require a further thermal annealing treatment (only processing at room temperature). The room-temperature processing and effective WF reduction enable the demonstration of high-performance (12.5%) flexible NF OSCs.

  • 3.
    Yao, Huifeng
    et al.
    Chinese Acad Sci, Peoples R China.
    Cui, Yong
    Univ Chinese Acad Sci, Peoples R China.
    Qian, Deping
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Ponseca, Carlito
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Honarfar, Alireza
    Lund Univ, Sweden.
    Xu, Ye
    Univ Chinese Acad Sci, Peoples R China.
    Xin, Jingming
    Xi An Jiao Tong Univ, Peoples R China.
    Chen, Zhenyu
    Xi An Jiao Tong Univ, Peoples R China.
    Hong, Ling
    Univ Chinese Acad Sci, Peoples R China.
    Gao, Bowei
    Univ Chinese Acad Sci, Peoples R China.
    Yu, Runnan
    Univ Chinese Acad Sci, Peoples R China.
    Zu, Yunfei
    Univ Chinese Acad Sci, Peoples R China.
    Ma, Wei
    Xi An Jiao Tong Univ, Peoples R China.
    Chabera, Pavel
    Lund Univ, Sweden.
    Pullerits, Tonu
    Lund Univ, Sweden.
    Yartsev, Arkady
    Lund Univ, Sweden.
    Gao, Feng
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Hou, Jianhui
    Univ Chinese Acad Sci, Peoples R China.
    14.7% Efficiency Organic Photovoltaic Cells Enabled by Active Materials with a Large Electrostatic Potential Difference2019In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 141, no 19, p. 7743-7750Article in journal (Refereed)
    Abstract [en]

    Although significant improvements have been achieved for organic photovoltaic cells (OPVs), the top-performing devices still show power conversion efficiencies far behind those of commercialized solar cells. One of the main reasons is the large driving force required for separating electron-hole pairs. Here, we demonstrate an efficiency of 14.7% in the single-junction OPV by using a new polymer donor PTO2 and a nonfullerene acceptor IT-4F. The device possesses an efficient charge generation at a low driving force. Ultrafast transient absorption measurements probe the formation of loosely bound charge pairs with extended lifetime that impedes the recombination of charge carriers in the blend. The theoretical studies reveal that the molecular electrostatic potential (ESP) between PTO2 and IT-4F is large, and the induced intermolecular electric field may assist the charge generation. The results suggest OPVs have the potential for further improvement by judicious modulation of ESP.

  • 4.
    Ha, Soonhoi
    et al.
    Seoul Natl Univ, South Korea.
    Eles, Petru Ion
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    2018 Embedded Systems Week (ESWEEK) in Torino2019In: IEEE design & test, ISSN 2168-2356, E-ISSN 2168-2364, Vol. 36, no 1, p. 68-69Article in journal (Other academic)
    Abstract [en]

    n/a

  • 5.
    Asa, Sylvia
    et al.
    Department of Pathology, University Health Network, Toronto, Ontario, Canada.
    Bodén, Anna
    Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.
    Treanor, Darren
    University of Leeds, and Leeds Teaching Hospitals NHS Trust Leeds, UK.
    Lundström, Claes
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Pantatnowitz, Liron
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, USA.
    2020 vision of digital pathology in action2019In: Journal of Pathology Informatics, ISSN 2229-5089, E-ISSN 2153-3539, Vol. 10, no 27Article in journal (Refereed)
  • 6.
    Persson, Ingemar
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Halim, Joseph
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Lind, Hans
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Hansen, Thomas W.
    Tech Univ Denmark DTU, Denmark.
    Wagner, Jakob B.
    Tech Univ Denmark DTU, Denmark.
    Näslund, Lars-Åke
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Darakchieva, Vanya
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Palisaitis, Justinas
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Rosén, Johanna
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Persson, Per O A
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    2D Transition Metal Carbides (MXenes) for Carbon Capture2019In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 31, no 2, article id 1805472Article in journal (Refereed)
    Abstract [en]

    Global warming caused by burning of fossil fuels is indisputably one of mankinds greatest challenges in the 21st century. To reduce the ever-increasing CO2 emissions released into the atmosphere, dry solid adsorbents with large surface-to-volume ratio such as carbonaceous materials, zeolites, and metal-organic frameworks have emerged as promising material candidates for capturing CO2. However, challenges remain because of limited CO2/N-2 selectivity and long-term stability. The effective adsorption of CO2 gas (approximate to 12 mol kg(-1)) on individual sheets of 2D transition metal carbides (referred to as MXenes) is reported here. It is shown that exposure to N-2 gas results in no adsorption, consistent with first-principles calculations. The adsorption efficiency combined with the CO2/N-2 selectivity, together with a chemical and thermal stability, identifies the archetype Ti3C2 MXene as a new material for carbon capture (CC) applications.

    The full text will be freely available from 2019-11-04 08:00
  • 7.
    Ha, Hojin
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Kangwon Natl Univ, South Korea.
    Escobar Kvitting, John-Peder
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Thoracic and Vascular Surgery. Linköping University, Center for Medical Image Science and Visualization (CMIV). Oslo Univ Hosp, Norway.
    Dyverfeldt, Petter
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Ebbers, Tino
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    4D Flow MRI quantification of blood flow patterns, turbulence and pressure drop in normal and stenotic prosthetic heart valves2019In: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 55, p. 118-127Article in journal (Refereed)
    Abstract [en]

    Purpose: To assess valvular flow characteristics and pressure drop in a variety of normal and stenotic prosthetic heart valves (PHVs) using 4D Flow MRI. Materials and methods: In-vitro flow phantoms with four different PHVs were studied: Medtronic-Hall tilting disc, St. Jude Medical standard bileaflet (STJM), Medtronic CoreValve Evolut R and Edwards SAPIEN 3. The valvular flow characteristics were investigated in normal and stenotic PHVs by using 4D Flow MRI. Results: The results showed that each valve provided a different amount of signal loss in the 4D Flow MRI. The defect size of the signal loss from each valve was 37.5 mm, 39.0 mm, 37.5 mm and 51.0 mm for the Tilting disk, STJM, SAPIEN 3 and CoreValve, respectively. The 4D Flow MRI-based estimation of the elevation of the pressure drop through the stenotic PHV using both Bernoulli-based and turbulence-based methods correlated well with the true values for the Tilting disc, STJM and SAPIEN 3 valve. However, the obstructive hemodynamics in the stenotic CoreValve was not clearly identified due to the large signal void from the long struts, resulting in a severe underestimation of the pressure drop using 4D Flow MRI. Conclusion: The Tilting disc, STJM and SAPIEN 3 valves provided reasonable estimates of peak velocity, turbulence production and the corresponding pressure drop. In contrast, the large strut of the CoreValve and corresponding signal void prevented accurate measurements of the velocity and turbulence production; therefore, 4D Flow MRI prediction of the pressure drop through the CoreValve was not feasible.

  • 8.
    Bartha, Erzsebet
    et al.
    Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
    Davidson, Thomas
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Berg, Hans E.
    Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden.
    Kalman, Sigridur
    Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
    A 1-year perspective on goal-directed therapy in elderly with hip fracture: Secondary outcomes2019In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 63, no 5, p. 610-614Article in journal (Refereed)
    Abstract [en]

    Background We have previously reported inconclusive results from a randomized controlled trial in elderly with hip-fracture comparing intra-operative goal-directed therapy with routine fluid treatment. Now we aimed to describe and compare secondary outcomes at 4 months and 1 year follow-up and to analyze the cost-effectiveness. Methods Patients with hip fracture (age amp;gt;= 70) were randomized for GDT or routine fluid treatment (RFT). The secondary outcomes were long-term survival, complications, number of hospital readmissions, and quality of life (EQ-5D) changes. Additionally, cost effectiveness was analyzed by an analytic tool which combines the clinical effectiveness, quality of life changes and costs. Results Patient data (GDT n = 74; RFT n = 75) were analyzed on an intention to treat basis. Statistically significant differences (GDT vs RFT) were not found considering survival (RR 0.76, 95%CI 0.45-1.28) and complications (RR 0.68, 95% CI 0.4-1.10) at 12 months. No statistically significant difference was found between hospital readmissions and quality of life changes. Conclusion The statistical uncertainty of risk reduction of negative outcomes and the large variability of the collected data indicate the need of further research in large sample sizes. To enable future health economic evaluation for decision support surrounding implementation of GDT, we suggest adding patient-oriented outcomes in future trials.

  • 9.
    Buck, Harleah G.
    et al.
    Univ S Florida, FL 33620 USA.
    Bekelman, David
    Univ Colorado Denver Anschutz Med Campus, CO USA.
    Cameron, Jan
    Monash Univ, Australia.
    Chung, Misook
    Univ Kentucky, KY USA.
    Hooker, Stephanie
    Univ Minnesota Twin Cities, MN USA.
    Pucciarelli, Gianluca
    Univ Roma Tor Vergata, Italy.
    Strömberg, Anna
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
    Riegel, Barbara
    Univ Penn, PA 19104 USA.
    Vellone, Ercole
    Univ Roma Tor Vergata, Italy.
    A body of work, a missed opportunity: Dyadic research in older adults2019In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 67, no 4, p. 854-855Article in journal (Other academic)
    Abstract [en]

    n/a

  • 10.
    Stratmann, Johannes
    et al.
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
    Ekman, Helen
    Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Thor, Stefan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences. School of Biomedical Sciences, University of Queensland, Australia.
    A branching gene regulatory network dictating different aspects of a neuronal cell identity2019In: Development, ISSN 0950-1991, E-ISSN 1477-9129, Vol. 146, no 6, article id UNSP 174300Article in journal (Refereed)
    Abstract [en]

    The nervous system displays a daunting cellular diversity. Neuronal subtypes differ from each other in several aspects, including their neurotransmitter expression and axon projection. These aspects can converge, but can also diverge, such that neurons expressing the same neurotransmitter may project axons to different targets. It is not well understood how regulatory programs converge/ diverge to associate/dissociate different cell fate features. Studies of the Drosophila Tv1 neurons have identified a regulatory cascade, ladybird early -amp;gt; collier -amp;gt; apterous/eyes absent -amp;gt; dimmed, that specifies Tv1 neurotransmitter expression. Here, we conduct genetic and transcriptome analysis to address how other aspects of Tv1 cell fate are governed. We find that an initiator terminal selector gene triggers a feedforward loop that branches into different subroutines, each of which establishes different features of this one unique neuronal cell fate.

  • 11.
    Radits, Markus
    Linköping University, Department of Management and Engineering, Industrial Economics. Linköping University, Faculty of Science & Engineering.
    A Business Ecology Perspective on Community-Driven Open Source: The Case of the Free and Open Source Content Management System Joomla2019Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This thesis approaches the phenomenon of open source software (OSS) from a managerial and organisational point of view. In a slightly narrower sense, this thesis studies commercialisation aspects around community-driven open source. The term ‘community-driven’ signifies open source projects that are managed, steered, and controlled by communities of volunteers, as opposed to those that are managed, steered, and controlled by single corporate sponsors.

    By adopting a business ecology perspective, this thesis places emphasis on the larger context within which the commercialisation of OSS is embedded (e.g., global and collaborative production regimes, ideological foundations, market characteristics, and diffuse boundary conditions). Because many business benefits arise as a consequence of the activities taking place in the communities and ecosystems around open source projects, a business ecology perspective may be a useful analytical guide for understanding the opportunities, challenges, and risks that firms face in commercializing OSS.

    There are two overarching themes guiding this thesis. The first theme concerns the challenges that firms face in commercialising community-driven open source. There is a tendency in the literature on business ecosystems and open source to emphasise the benefits, opportunities, and positive aspects of behaviour, at the expense of the challenges that firms face. However, business ecosystems are not only spaces of opportunity, they may also pose a variety of challenges that firms need to overcome in order to be successful. To help rectify this imbalance in the literature, the first theme particularly focuses on the challenges that firms face in commercialising community-driven open source. The underlying ambition is to facilitate a more balanced and holistic understanding of the collaborative and competitive dynamics in ecosystems around open source projects.

    The other theme concerns the complex intertwining of community engagement and profit-oriented venturing. As is acknowledged in the literature, the subject of firm-community interaction has become increasingly important because the survival, success, and sustainability of peer production communities has become of strategic relevance to many organisations. However, while many strategic benefits may arise as a consequence of firm-community interaction, there is a lack of research studying how the value-creating logics of firm–community interaction are embedded within the bigger picture in which they occur. Bearing this bigger picture in mind, this thesis explores the intertwining of volunteer community engagement and profit-oriented venturing by focusing on four aspects that are theorised in the literature: reinforcement, complementarity, synergy, and reciprocity.

    This thesis is designed as a qualitative exploratory single-case study. The empirical case is Joomla, a popular open source content management system. In a nutshell, the Joomla case in this thesis comprises the interactions in the Joomla community and the commercial activities around the Joomla platform (e.g., web development, consulting, marketing, customisation, extensions). In order to achieve greater analytical depth, the business ecology perspective is complemented with ideas and propositions from other theoretical areas, such as stakeholder theory, community governance, organizational identity, motivation theory, pricing, and bundling.

    The findings show that the common challenges in commercialising community-driven open source revolve around nine distinct factors that roughly cluster into three domains: the ecosystem, the community, and the firm. In short, the domain of the ecosystem comprises the global operating environment, the pace of change, and the cannibalisation of ideas. The domain of the community comprises the platform policy, platform image, and the voluntary nature of the open source project. And finally, the domain of the firm comprises the blurring boundaries between private and professional lives, the difficulty of estimating costs, and firm dependencies. Based on these insights, a framework for analysing community-based value creation in business ecosystems is proposed. This framework integrates collective innovation, community engagement, and value capture into a unified model of value creation in contexts of firm–community interaction.

    Furthermore, the findings reveal demonstrable effects of reinforcement, complementarity, synergy, and reciprocity in the intertwining of volunteer community engagement and profit-oriented venturing. By showing that this intertwining can be strong in empirical cases where commercial activities are often implicitly assumed to be absent, this thesis provides a more nuanced understanding of firm involvement in the realm of open source.

    Based on the empirical and analytical insights, a number of further theoretical implications are discussed, such as the role of intersubjective trust in relation to the uncertainties that commercial actors face, an alternative way of classifying community types, the metaphor of superorganisms in the context of open source, issues pertaining to the well-being of community participants, and issues in relation to the transitioning of open source developers from a community-based to an entrepreneurial self-identity when commercialising an open source solution. Furthermore, this thesis builds on six sub-studies that make individual contributions of their own.

    In a broad sense, this thesis contributes to the literature streams on the commercialisation of OSS, the business value and strategic aspects of open source, the interrelationships between community forms of organising and entrepreneurial activities, and the nascent research on ecology perspectives on peer-production communities. A variety of opportunities for future research are highlighted.

  • 12.
    Gardiner, Stephen J.
    et al.
    Univ Coll Dublin, Ireland.
    Sjödin, Tomas
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    A characterization of annular domains by quadrature identities2019In: Bulletin of the London Mathematical Society, ISSN 0024-6093, E-ISSN 1469-2120, Vol. 51, no 3, p. 436-442Article in journal (Refereed)
    Abstract [en]

    This note verifies a conjecture of Armitage and Goldstein that annular domains may be characterized as quadrature domains for harmonic functions with respect to a uniformly distributed measure on a sphere.

  • 13.
    Hellstrom, Amanda
    et al.
    Linnaeus Univ, Sweden.
    Hagell, Peter
    Kristianstad Univ, Sweden.
    Broström, Anders
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Clinical Neurophysiology. Jonkoping Univ, Sweden.
    Ulander, Martin
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Clinical Neurophysiology.
    Luik, Annemarie I.
    Univ Oxford, England; Erasmus MC Univ Med Ctr, Netherlands.
    Espie, Colin A.
    Univ Oxford, England.
    Arestedt, Kristofer
    Linnaeus Univ, Sweden; Reg Kalmar Cty, Sweden.
    A classical test theory evaluation of the Sleep Condition Indicator accounting for the ordinal nature of item response data2019In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 3, article id e0213533Article in journal (Refereed)
    Abstract [en]

    Background Insomnia symptoms are common among young adults and affect about 5% to 26% of 19 to 34-year-olds. In addition, insomnia is associated with poor mental health and may affect daily performance. In research, as well as in clinical practice, sleep questionnaires are used to screen for and diagnose insomnia. However, most questionnaires are not developed according to current DSM-5 diagnostic criteria. An exception is the recently developed Sleep Condition Indicator (SCI), an eight-item scale screening for insomnia. Aim The aim of this study was to perform a Classical Test Theory (CTT) based psychometric evaluation of the SCI in a sample of Swedish university students, by taking the ordinal nature of item level data into account. Methods The SCI was translated into Swedish and distributed online to undergraduate students at three Swedish universities, within programs of health, psychology, science or economy. Of 3673 invited students, 634 (mean age 26.9 years; SD = 7.4) completed the questionnaire that, in addition to the SCI, comprised other scales on sleep, stress, lifestyle and students study environment. Data were analyzed according to CTT investigating data completeness, item homogeneity and unidimensionality. Results Polychoric based explorative factor analysis suggested unidimensionality of the SCI, and internal consistency was good (Cronbachs alpha, 0.91; ordinal alpha, 0.94). SCI scores correlated with the Insomnia Severity Index (-0.88) as well as with sleep quality (-0.85) and perceived stress (-0.50), supporting external construct validity. Conclusions These observations support the integrity of the of the SCI. The SCI demonstrates sound CTT-based psychometric properties, supporting its use as an insomnia screening tool.

  • 14.
    Jung, Daniel
    et al.
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, Faculty of Science & Engineering.
    Sundström, Christofer
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, Faculty of Science & Engineering.
    A Combined Data-Driven and Model-Based Residual Selection Algorithm for Fault Detection and Isolation2019In: IEEE Transactions on Control Systems Technology, ISSN 1063-6536, E-ISSN 1558-0865, Vol. 27, no 2, p. 616-630Article in journal (Refereed)
    Abstract [en]

    Selecting residual generators for detecting and isolating faults in a system is an important step when designing model-based diagnosis systems. However, finding a suitable set of residual generators to fulfill performance requirements is complicated by model uncertainties and measurement noise that have negative impact on fault detection performance. The main contribution is an algorithm for residual selection that combines model-based and data-driven methods to find a set of residual generators that maximizes fault detection and isolation performance. Based on the solution from the residual selection algorithm, a generalized diagnosis system design is proposed where test quantities are designed using multivariate residual information to improve detection performance. To illustrate the usefulness of the proposed residual selection algorithm, it is applied to find a set of residual generators to monitor the air path through an internal combustion engine.

  • 15.
    Karlsson, Anna
    et al.
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.
    Cirenajwis, Helena
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.
    Ericson-Lindquist, Kajsa
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Pathology, Regional Laboratories Region Skåne, Lund, Sweden.
    Brunnstrom, Hans
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Pathology, Regional Laboratories Region Skåne, Lund, Sweden.
    Reutersward, Christel
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.
    Jönsson, Mats
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.
    Ortiz-Villalon, Cristian
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
    Hussein, Aziz
    Department of Pathology and cytology, Sahlgrenska university hospital, Gothenburg, Sweden.
    Bergman, Bengt
    Department of Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Vikström, Anders
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Respiratory Medicine.
    Monsef, Nastaran
    Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.
    Branden, Eva
    Respiratory Medicine Unit, Department of Medicine Solna and CMM, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; Centre for Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden.
    Koyi, Hirsh
    Respiratory Medicine Unit, Department of Medicine Solna and CMM, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; Centre for Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden.
    de Petris, Luigi
    Thoracic Oncology Unit, Karolinska University Hospital and Department Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
    Micke, Patrick
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Patthey, Annika
    Department of Pathology, Umeå University Hospital, Umeå, Sweden.
    Behndig, Annelie F.
    Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.
    Johansson, Mikael
    Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
    Planck, Maria
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden; Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden.
    Staaf, Johan
    Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.
    A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 5207Article in journal (Refereed)
    Abstract [en]

    Accurate histological classification and identification of fusion genes represent two cornerstones of clinical diagnostics in non-small cell lung cancer (NSCLC). Here, we present a NanoString gene expression platform and a novel platform-independent, single sample predictor (SSP) of NSCLC histology for combined, simultaneous, histological classification and fusion gene detection in minimal formalin fixed paraffin embedded (FFPE) tissue. The SSP was developed in 68 NSCLC tumors of adenocarcinoma (AC), squamous cell carcinoma (SqCC) and large-cell neuroendocrine carcinoma (LCNEC) histology, based on NanoString expression of 11 (CHGA, SYP, CD56, SFTPG, NAPSA, TTF-1, TP73L, KRT6A, KRT5, KRT40, KRT16) relevant genes for IHC-based NSCLC histology classification. The SSP was combined with a gene fusion detection module (analyzing ALK, RET, ROS1, MET, NRG1, and NTRK1) into a multicomponent NanoString assay. The histological SSP was validated in six cohorts varying in size (n = 11-199), tissue origin (early or advanced disease), histological composition (including undifferentiated cancer), and gene expression platform. Fusion gene detection revealed five EML4-ALK fusions, four KIF5B-RET fusions, two CD74-NRG1 fusion and three MET exon 14 skipping events among 131 tested cases. The histological SSP was successfully trained and tested in the development cohort (mean AUC = 0.96 in iterated test sets). The SSP proved successful in predicting histology of NSCLC tumors of well-defined subgroups and difficult undifferentiated morphology irrespective of gene expression data platform. Discrepancies between gene expression prediction and histologic diagnosis included cases with mixed histologies, true large cell carcinomas, or poorly differentiated adenocarcinomas with mucin expression. In summary, we present a proof-of-concept multicomponent assay for parallel histological classification and multiplexed fusion gene detection in archival tissue, including a novel platform-independent histological SSP classifier. The assay and SSP could serve as a promising complement in the routine evaluation of diagnostic lung cancer biopsies.

  • 16.
    Alfredsson Ågren, Kristin
    et al.
    Linköping University, Department of Social and Welfare Studies, Division of Occupational Therapy. Linköping University, Faculty of Medicine and Health Sciences.
    Kjellberg, Anette
    Linköping University, Department of Social and Welfare Studies, Division of Occupational Therapy. Linköping University, Faculty of Medicine and Health Sciences.
    Hemmingsson, Helena
    Linköping University, Department of Social and Welfare Studies, Division of Occupational Therapy. Linköping University, Faculty of Medicine and Health Sciences.
    A comparartive study on internet usage in adolescents with intellectual disabilities and a reference group in Sweden.2019In: Journal of Intellectual Disability Research, JIDR: Future4All; Comparative Policy and Practice, John Wiley & Sons, 2019, Vol. 63, p. 710-726, article id 7Conference paper (Refereed)
  • 17.
    Shi, Yuchen
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Jokubavicius, Valdas
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Höjer, Pontus
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Ivanov, Ivan Gueorguiev
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Yazdi, Gholamreza
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Yakimova, Rositsa
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Syväjärvi, Mikael
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Sun, Jianwu W.
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    A comparative study of high-quality C-face and Si-face 3C-SiC(1 1 1) grown on off-oriented 4H-SiC substrates2019In: Journal of Physics D: Applied Physics, ISSN 0022-3727, E-ISSN 1361-6463, Vol. 52, no 34Article in journal (Refereed)
    Abstract [en]

    We present a comparative study of the C-face and Si-face of 3C-SiC(111) grown on off-oriented 4H-SiC substrates by the sublimation epitaxy. By the lateral enlargement method, we demonstrate that the high-quality bulk-like C-face 3C-SiC with thickness of ~1 mm can be grown over a large single domain without double positioning boundaries (DPBs), which are known to have a strongly negative impact on the electronic properties of the material. Moreover, the C-face sample exhibits a smoother surface with one unit cell height steps while the surface of the Si-face sample exhibits steps twice as high as on the C-face due to step-bunching. High-resolution XRD and low temperature photoluminescence measurements show that C-face 3C-SiC can reach the same high crystalline quality as the Si-face 3C-SiC. Furthermore, cross-section studies of the C- and Si-face 3C-SiC demonstrate that in both cases an initial homoepitaxial 4H-SiC layer followed by a polytype transition layer are formed prior to the formation and lateral expansion of 3C-SiC layer. However, the transition layer in the C-face sample is extending along the step-flow direction less than that on the Si-face sample, giving rise to a more fairly consistent crystalline quality 3C-SiC epilayer over the whole sample compared to the Si-face 3C-SiC where more defects appeared on the surface at the edge. This facilitates the lateral enlargement of 3C-SiC growth on hexagonal SiC substrates.

  • 18.
    Wang, Jianqiu
    et al.
    Beihang Univ, Peoples R China; Natl Ctr Nanosci and Technol, Peoples R China.
    Xu, Jianqiu
    Nanjing Univ, Peoples R China.
    Yao, Nannan
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhang, Dongyang
    Beihang Univ, Peoples R China.
    Zheng, Zhong
    Natl Ctr Nanosci and Technol, Peoples R China.
    Xie, Shenkun
    Beihang Univ, Peoples R China; Natl Ctr Nanosci and Technol, Peoples R China.
    Zhang, Xuning
    Beihang Univ, Peoples R China.
    Zhang, Fengling
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhou, Huiqiong
    Natl Ctr Nanosci and Technol, Peoples R China.
    Zhang, Chunfeng
    Nanjing Univ, Peoples R China.
    Zhang, Yuan
    Beihang Univ, Peoples R China.
    A Comparative Study on Hole Transfer Inversely Correlated with Driving Force in Two Non-Fullerene Organic Solar Cells2019In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 10, no 14, p. 4110-4116Article in journal (Refereed)
    Abstract [en]

    We report a faster rate of hole transfer under a smaller AHomo in a comparative study of two group organic solar cells (OSCs) consisting of IT-4F as an acceptor and PBDBT and PBDBT-SF as donors. In the OSCs based on PBDBT. SF:IT-4F, a higher short-circuit current (J(SC)) was observed with a Delta(Homo) of 0.31 eV compared to a lower Jsc in PBDBT:IT-4F OSCs with a larger Delta(Homo) (0.45 eV). Intensive investigation indicates that the rate of transfer of a hole from IT-4F to PBDBT-SF or PBDBT is inversely proportional to the Delta(Homo) between IT-4F and donors. The larger Jsc in the PBDBT-SF:IT-4F device is attributed to a synergy of faster hole transfer, slower recombination, and rapid charge extraction enabled by desired morphology and balanced charge carrier mobilities with PBDBT-SF, suggesting that under a sufficiently high Delta(Homo), comprehensive considerations of the transport, film morphology, and energy levels are needed when designing new materials for high-performance OSCs.

  • 19.
    Latorre, Malcolm
    et al.
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    Wårdell, Karin
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    A comparison between single and double cable neuron models applicable to deep brain stimulation2019In: Biomedical Physics & Engineering Express, E-ISSN 2057-1976, Vol. 5, no 2Article in journal (Refereed)
    Abstract [en]

    Computational models for activation assessment in deep brain stimulation (DBS) are commonly based on neuronal cable equations. The aim was to systematically compare the activation distance between a single cable model implemented in MATLAB, and a well-established double cable model implemented in NEURON. Both models have previously been used for DBS studies. The field distributions generated from a point source and a 3389 DBS lead were applied to the neuron models as input stimuli. Simulations (n = 670) were performed with intersecting axon diameters (D) between the models (2.0, 3.0, 5.7, 7.3, 8.7, 10.0 μm), variation in pulse shape and amplitude settings (0 to 5 in increments of 0.5 mA or V) with the single cable model as reference. Both models responded linearly to change of input (point source: 0.93 < R2 < 0.99, DBS source: R2 > 0.98), but with a systematic extended activation distance for the single cable model. The difference for a point source ranged from −0.2 mm (D = 2.0 μm) to −1.1 mm (D = 5.7 μm). For the DBS lead a D = 3.2 μm agreed with the commonly used double cable simulations D =5.7 μm in voltage mode. Possible reasons for the deviation at larger axons are the internodal length, the ion channel selection and physiological data behind the models. The single cable model covers a continuous range of small axon diameters and calculated the internodal length for each iteration, whereas the double cable models uses fixed defined axon diameters and tabulated data for the internodal length. Despite different implementations and model complexities, both models present similar sensitivity to pulse shape, amplitude and axon diameter. With awareness of the strength and weakness both models can be used to extract activation distance used to relate a specific electric field isolevel and thus estimate the volume of tissue activated in DBS simulation studies.

  • 20.
    Sundell, Anna Lena
    et al.
    Inst Postgrad Dent Educ, Sweden.
    Marcusson, Agneta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    A comparison of orofacial profiles in 5-and 10-year-old Swedish children with and without cleft lip and/or palate2019In: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 23, no 3, p. 1341-1347Article in journal (Refereed)
    Abstract [en]

    ObjectivesThe objectives of this study were to assess orofacial profiles in 5- and 10-year-old children with cleft lip and/or palate (CL/P) compared to controls and to estimate a possible association between orofacial dysfunction and caries frequency.Materials and methodsA total of 133 children with CL/P (77 5-year-olds and 56 10-year-olds) and 308 controls (142 5-year-olds and 166 10-year-olds) were included in the study. Orofacial function was evaluated with Nordic Orofacial Test-Screening (NOT-S), and caries were scored according to the International Caries Detection and Assessment System (ICDAS).ResultsThe total NOT-S score was higher in children with CL/P compared to controls (mean 3.2 vs 0.9, pamp;lt;0.001). The domains frequently scored in CL/P children were speech (82%), face at rest (72%), and facial expression (58%). There was a significantly positive correlation between NOT-S scores and caries frequency.ConclusionsChildren with CL/P have impaired orofacial function compared to controls. There seems to be a correlation between orofacial function and caries.Clinical relevanceImpaired orofacial function seen in children with CL/P can be one of many risk factors for caries development, and it is suggested to be a part of caries risk assessment.

  • 21.
    Kozlov, Vladimir
    et al.
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Kuznetsov, N.
    Russian Acad Sci, Russia.
    A COMPARISON THEOREM FOR SUPER- AND SUBSOLUTIONS OF del(2)u + f(u)=0 AND ITS APPLICATION TO WATER WAVES WITH VORTICITY2019In: St. Petersburg Mathematical Journal, ISSN 1061-0022, E-ISSN 1547-7371, Vol. 30, no 3, p. 471-483Article in journal (Refereed)
    Abstract [en]

    A comparison theorem is proved for a pair of solutions that satisfy opposite nonlinear differential inequalities in a weak sense. The nonlinearity is of the form f (u) with f belonging to the class L-loc(p) and the solutions are assumed to have nonvanishing gradients in the domain, where the inequalities are considered. The comparison theorem is applied to the problem describing steady, periodic water waves with vorticity in the case of arbitrary free-surface profiles including overhanging ones. Bounds for these profiles as well as streamfunctions and admissible values of the total head are obtained.

  • 22.
    Jonsson, Anna K.
    et al.
    Natl Board Forens Med, Dept Forens Chem and Genet, Linkoping, Sweden.
    Spigset, Olav
    St Olavs Univ Hosp, Norway; Norwegian Univ Sci and Technol, Norway.
    Reis, Margareta
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Sickle Univ Hosp, Sweden.
    A Compilation of Serum Concentrations of 12 Antipsychotic Drugs in a Therapeutic Drug Monitoring Setting2019In: Therapeutic Drug Monitoring, ISSN 0163-4356, E-ISSN 1536-3694, Vol. 41, no 3, p. 348-356Article in journal (Refereed)
    Abstract [en]

    Background: No comprehensive collection of routine therapeutic drug monitoring data for antipsychotic drugs has been published. Methods: In this compilation, data on 12 antipsychotics are presented. The drugs included are amisulpride (n = 506), aripiprazole (n = 1610), clozapine (n = 1189), flupentixol (n = 215), haloperidol (n = 390), olanzapine (n = 10,268), perphenazine (n = 1065), quetiapine (n = 5853), risperidone (n = 3255), sertindole (n = 111), ziprasidone (n = 1235), and zuclopenthixol (n = 691). Because only one sample per patient is included, the number of patients equals the number of samples. For each drug, median serum concentrations as well as that of the 10th and 90th percentiles are given for a range of daily doses. Comparisons are made between males and females, between patients younger than 65 years and 65 years and older, and between those treated with a low and a high dose of each drug. The concentration-to-dose (C/D) ratio is the primary variable used in these comparisons. Coefficients of variation (CVs) for the serum concentrations of each drug within and between subjects are presented. Results: In general, the C/D ratios were higher in females than in males, higher in those 65 years and older than in younger subjects, and lower in those treated with higher doses than in those treated with lower doses. CVs between individuals were larger than within subjects, and the CVs were highest for the drugs with short elimination half-lives. Conclusions: For each antipsychotic drug, the results presented can serve as a reference tool for pharmacokinetic interpretation of the individual patients serum drug level. The compiled serum concentrations and the C/D ratios can support the physicians decision when individualizing dosing and determining treatment strategies for a specific patient.

  • 23.
    Dermentzis, Georgios
    et al.
    Unit for Energy Efficient Building, University of Innsbruck, Innsbruck, Austria.
    Ochs, Fabian
    Unit for Energy Efficient Building, University of Innsbruck, Innsbruck, Austria.
    Gustafsson, Marcus
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Calabrese, Toni
    Unit for Energy Efficient Building, University of Innsbruck, Innsbruck, Austria.
    Siegele, Dietmar
    Unit for Energy Efficient Building, University of Innsbruck, Innsbruck, Austria.
    Feist, Wolfgang
    Unit for Energy Efficient Building, University of Innsbruck, Innsbruck, Austria; Passive House Institute, Darmstadt, Germany.
    Dipasquale, Chiara
    EURAC Research, Bolzano, Italy.
    Fedrizzi, Roberto
    EURAC Research, Bolzano, Italy.
    Bales, Chris
    Energy Technology, Dalarna University, Falun, Sweden.
    A comprehensive evaluation of a monthly-based energy auditing tool through dynamic simulations, and monitoring in a renovation case study2019In: Energy and Buildings, ISSN 0378-7788, E-ISSN 1872-6178, Vol. 183, p. 713-726Article in journal (Refereed)
    Abstract [en]

    An energy auditing tool (PHPP) was evaluated against a dynamic simulation tool (TRNSYS) and used for the assessment of energy conservation measures in a demo case study. The comprehensive comparison of heating and cooling useful demands and loads included three building types (single-, multi-family house, and office), three building energy levels (before renovation and after renovation with a heating demand of 45 and 25 kWh/(m²·a)) and seven European climates.

    Dynamic simulation results proved PHPP (monthly energy balance) to be able to calculate heating demand and energy savings with good precision and cooling demand with acceptable precision compared to detailed numerical models (TRNSYS). The average deviation between the tools was 8% for heating and 15% for cooling (considering climates with a relevant cooling load only). The higher the thermal envelope quality was, i.e. in case of good energy standards and in cold climates, the better was the agreement. Furthermore, it was confirmed that PHPP slightly overestimates the heating and cooling loads by intention for system design.

    The renovation design of a real multi-family house was executed using PHPP as energy auditing tool. Several calculation stages were performed for (a) baseline, (b) design phase, and (c) verification with monitoring in order to calculate the corresponding heating demand. The PHPP model was calibrated twice, before and after the renovation. The necessity for tool calibration, especially for the baseline, was highlighted increasing the confidence with respect to a number of boundary conditions.

    In this study, PHPP was tested as an energy auditing tool aiming to be a versatile and less error-prone alternative to more complex simulation tools, which require much more expert knowledge and training.

  • 24.
    Ren, Shan
    et al.
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, 710072, PR China.
    Zhang, Yingfeng
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, 710072, PR China / Research & Development Institute in Shenzhen, Northwestern Polytechnical University, PR China.
    Liu, Yang
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering. Department of Production, University of Vaasa, 65200, Vaasa, Finland.
    Sakao, Tomohiko
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Huisingh, Donald
    Institute for a Secure and Sustainable Environment, University of Tennessee, Knoxville, TN, USA.
    Almeida, Cecilia M. V. B.
    Paulista University, São Paulo, Brazil.
    A comprehensive review of big data analytics throughout product lifecycle to support sustainable smart manufacturing: A framework, challenges and future research directions2019In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 210, p. 1343-1365Article, review/survey (Refereed)
    Abstract [en]

    Smart manufacturing has received increased attention from academia and industry in recent years, as it provides competitive advantage for manufacturing companies making industry more efficient and sustainable. As one of the most important technologies for smart manufacturing, big data analytics can uncover hidden knowledge and other useful information like relations between lifecycle decisions and process parameters helping industrial leaders to make more-informed business decisions in complex management environments. However, according to the literature, big data analytics and smart manufacturing were individually researched in academia and industry. To provide theoretical foundations for the research community to further develop scientific insights in applying big data analytics to smart manufacturing, it is necessary to summarize the existing research progress and weakness. In this paper, through combining the key technologies of smart manufacturing and the idea of ubiquitous servitization in the whole lifecycle, the term of sustainable smart manufacturing was coined. A comprehensive overview of big data in smart manufacturing was conducted, and a conceptual framework was proposed from the perspective of product lifecycle. The proposed framework allows analyzing potential applications and key advantages, and the discussion of current challenges and future research directions provides valuable insights for academia and industry. (C) 2018 Elsevier Ltd. All rights reserved.

  • 25.
    Mulinari, Diana
    et al.
    Department of Gender Studies, Lund University, Lund, Sweden.
    Neergaard, Anders
    Linköping University, REMESO - Institute for Research on Migration, Ethnicity and Society. Linköping University, Faculty of Arts and Sciences.
    A contradiction in terms?: migrant activists in the Sweden Democrats party2019In: Identities: Global Studies in Culture and Power, ISSN 1070-289X, E-ISSN 1547-3384, Vol. 26, no 2, p. 222-240Article in journal (Refereed)
    Abstract [en]

    Right-wing, xenophobic and racist parties have enjoyed immense successes in Europe in recent decades. In Sweden, the third-largest party in Parliament is the Sweden Democrats (SD), with 13% in the 2014 general election. Sympathy for the SD among foreign-born Swedish citizens, both women and men, is far lower than among Sweden-born men, but an increasing number of Swedish citizens with migrant backgrounds support the party. The aim of this article is to explore the subject positions open for citizens with migrant background in the Swedish public space with special focus on the identities and worldviews developed by migrant activists who have joined the SD party and are, to differing degrees, racialised and perceived as non-Swedish. Using the concept of migrant respectability, this research is intended to understand why and under what circumstances migrants chose to join and represent a xenophobic and racist party.

  • 26.
    Duvetorp, Albert
    et al.
    Skane Univ Hosp, Sweden.
    Levin, Lars-Åke
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Engerstedt Mattsson, Emma
    LEO Pharma AS, Denmark.
    Ryttig, Lasse
    LEO Pharma AS, Denmark.
    A Cost-utility Analysis of Calcipotriol/Betamethasone Dipropionate Aerosol Foam versus Ointment for the Topical Treatment of Psoriasis Vulgaris in Sweden2019In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 99, no 4, p. 393-399Article in journal (Refereed)
    Abstract [en]

    Psoriasis is a chronic inflammatory disorder that imposes a substantial economic burden. We conducted a cost-utility analysis from a Swedish healthcare payers perspective using a decision-tree model with a 12-week time horizon. Patients with psoriasis vulgaris could have two 4-week cycles of topical treatment with calcipotriol 50 mu g/g and betamethasone 0.5 mg/g as dipropionate (Cal/BD) foam or Cal/BD ointment before progressing to phototherapy/methotrexate. In the base-case analysis, Cal/BD foam dominated over Cal/BD ointment. The increased efficacy of Cal/BD foam resulted in fewer consultations and a decreased risk of progressing to phototherapy/methotrexate. Although Cal/BD foam costs more than Cal/BD ointment, this was offset by lower costs for phototherapy/methotrexate or consultation visits. Sensitivity analyses revealed that the base-case net monetary benefit was robust to plausible variations in key parameters. In conclusion, Cal/BD foam was predicted to be more cost-effective than Cal/BD ointment in the treatment of psoriasis vulgaris.

  • 27.
    Mota, Fernando de Brito
    et al.
    Univ Fed Bahia, Brazil.
    Rivelino, Roberto
    Univ Fed Bahia, Brazil.
    Da Costa Medeiros, Paulo Vinicius
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, Faculty of Science & Engineering. Swedish Meteorol and Hydrol Inst, Sweden.
    de Castilho, Caio M. C.
    Univ Fed Bahia, Brazil.
    A critical assessment on the electron transport through dehydrogenated intrinsically conducting channels in graphane-graphene hybrids2019In: MATERIALS RESEARCH EXPRESS, ISSN 2053-1591, Vol. 6, no 8, article id 085618Article in journal (Refereed)
    Abstract [en]

    We investigate the electron transport properties of different extended line/ribbon defects in hydrogenated graphene (graphane) by means of density functional theory combined with the non-equilibrium Greens function formalism. The calculated zero-bias transmission profiles show that dehydrogenated tracks in graphane are promising candidates for fabricating printed nanocircuits. Our calculations also indicate that the gate-induced transmission probability of a completely dehydrogenated zigzag carbon line (DHZCL) in a freestanding graphane sheet opens a conduction channel in its insulating structure. The voltage-dependent transmission tends to increase for two weakly interacting DHZCL defects, although the transmission spectra critically depend on the proximity of these dehydrogenated lines. The current response to a bias voltage is also analyzed for the proposed defective devices and the calculated I-V characteristics show that one or two weakly interacting DHZCL defects in graphane behave as fair conduction channels from a certain threshold voltage. However, two immediately neighbor line defects (i.e., acene-type defects) exhibit a conducting behavior increasing from 0.0 to 0.2 V and a feature of a negative differential resistance effect under bias voltage in the 0.25-0.5 V range. These results suggest that extended 1D/2D defects in graphane-graphene hybrid platforms could be properly exploited for electronic applications in solid-state chemically gated graphene field-effect transistor.

  • 28.
    Liu, Yu
    et al.
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    Hassan, Kahin Akram
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Karlsson, Magnus
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics.
    Pang, Zhibo
    Corporate Research, ABB AB, Västerås, Sweden.
    Gong, Shaofang
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics.
    A Data-Centric Internet of Things Framework Based on Azure Cloud2019In: IEEE Access, E-ISSN 2169-3536, Vol. 7, p. 53839-53858Article in journal (Refereed)
    Abstract [en]

    Internet of Things (IoT) has been found pervasive use cases and become a driving force to constitute a digital society. The ultimate goal of IoT is data and the intelligence generated from data. With the progress in public cloud computing technologies, more and more data can be stored, processed and analyzed in cloud to release the power of IoT. However, due to the heterogeneity of hardware and communication protocols in the IoT world, the interoperability and compatibility among different link layer protocols, sub-systems, and back-end services have become a significant challenge to IoT practices. This challenge cannot be addressed by public cloud suppliers since their efforts are mainly put into software and platform services but can hardly be extended to end devices. In this paper, we propose a data-centric IoT framework that incorporates three promising protocols with fundamental security schemes, i.e., WiFi, Thread, and LoRaWAN, to cater to massive IoT and broadband IoT use cases in local, personal, and wide area networks. By taking advantages of the Azure cloud infrastructure, the framework features a unified device management model and data model to conquer the interoperability challenge. We also provide implementation and a case study to validate the framework for practical applications.

  • 29.
    Liu, Yu
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    A Data-centric Internet of Things Framework Based on Public Cloud2019Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The pervasive application of Internet of Things (IoT) has been seen in many aspects in human daily life and industrial production. The concept of IoT originates from traditional machine-to-machine (M2M) communications which aimed at solving domain-specific and applicationspecific problems. Today, the rapid progress of communication technologies, the maturation of Internet infrastructures, the continuously reduced cost of sensors, and emergence of more open standards, have witnessed the approaching of the expected IoT era, which envisions full connectivity between the physical world and the digital world via the Internet protocol. The popularity of cloud computing technology has enhanced this IoT transform, benefiting from the superior computing capability and flexible data storage, let alone the security, reliability and scalability advantages.

    However, there are still a series of obstacles confronted by the industry in deployment of IoT services. First, due to the heterogeneity of hardware devices and application scenarios, the interoperability and compatibility between link-layer protocols, sub-systems and back-end services are significantly challenging. Second, the device management requires a uniform scheme to implement the commissioning, communication, authorization and identity management to guarantee security. Last, the heterogeneity of data format, speed and storage mechanism for different services pose a challenge to further data mining.

    This thesis aims to solve these aforementioned challenges by proposing a data-centric IoT framework based on public cloud platforms. It targets at providing a universal architecture to facilitate the deployment of IoT services in massive IoT and broadband IoT categories. The framework involves three representative communication protocols, namely WiFi, Thread and Lo-RaWAN, to enable support for local, personal, and wide area networks. A security assessment taxonomy for wireless communications in building automation networks is proposed as a tool to evaluate the security performance of adopted protocols, so as to mitigate potential network flaws and guarantee the security. Azure cloud platform is adopted in the framework to provide device management, data processing and storage, visualization, and intelligent services, thanks to the mature cloud infrastructure and the uniform device model and data model. We also exhibit the value of the study by applying the framework into the digitalization procedure of the green plant wall industry. Based on the framework, a remote monitoring and management system for green plant wall is developed as a showcase to validate the feasibility. Furthermore, three specialized visualization methods are proposed and a neuron network-based anomaly detection method is deployed in the project, showing the potential of the framework in terms of data analytics and intelligence.

    List of papers
    1. A Data-Centric Internet of Things Framework Based on Azure Cloud
    Open this publication in new window or tab >>A Data-Centric Internet of Things Framework Based on Azure Cloud
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    2019 (English)In: IEEE Access, E-ISSN 2169-3536, Vol. 7, p. 53839-53858Article in journal (Refereed) Published
    Abstract [en]

    Internet of Things (IoT) has been found pervasive use cases and become a driving force to constitute a digital society. The ultimate goal of IoT is data and the intelligence generated from data. With the progress in public cloud computing technologies, more and more data can be stored, processed and analyzed in cloud to release the power of IoT. However, due to the heterogeneity of hardware and communication protocols in the IoT world, the interoperability and compatibility among different link layer protocols, sub-systems, and back-end services have become a significant challenge to IoT practices. This challenge cannot be addressed by public cloud suppliers since their efforts are mainly put into software and platform services but can hardly be extended to end devices. In this paper, we propose a data-centric IoT framework that incorporates three promising protocols with fundamental security schemes, i.e., WiFi, Thread, and LoRaWAN, to cater to massive IoT and broadband IoT use cases in local, personal, and wide area networks. By taking advantages of the Azure cloud infrastructure, the framework features a unified device management model and data model to conquer the interoperability challenge. We also provide implementation and a case study to validate the framework for practical applications.

    Place, publisher, year, edition, pages
    IEEE, 2019
    Keywords
    Internet of Things, Cloud computing, Protocols, Wireless fidelity, Broadband communication, Monitoring, Interoperability, framework, cloud, azure, IoT hub, thread, WiFi, lorawan
    National Category
    Computer and Information Sciences
    Identifiers
    urn:nbn:se:liu:diva-156704 (URN)10.1109/ACCESS.2019.2913224 (DOI)000467047300001 ()
    Note

    Funding agencies:  Swedish Environmental Protection Agency; Norrkoping Fund for Research and Development, Sweden

    Available from: 2019-05-10 Created: 2019-05-10 Last updated: 2019-08-21
    2. A Taxonomy for the Security Assessment of IP-based Building Automation Systems: The Case of Thread
    Open this publication in new window or tab >>A Taxonomy for the Security Assessment of IP-based Building Automation Systems: The Case of Thread
    2018 (English)In: IEEE Transactions on Industrial Informatics, ISSN 1551-3203, E-ISSN 1941-0050, Vol. 14, no 9, p. 4113-4123Article in journal (Refereed) Published
    Abstract [en]

    Motivated by the proliferation of wireless building automation systems (BAS) and increasing security-awareness among BAS operators, in this paper we propose a taxonomy for the security assessment of BASs. We apply the proposed taxonomy to Thread, an emerging native IP-based protocol for BAS. Our analysis reveals a number of potential weaknesses in the design of Thread. We propose potential solutions for mitigating several identified weaknesses and discuss their efficacy. We also provide suggestions for improvements in future versions of the standard. Overall, our analysis shows that Thread has a well-designed security control for the targeted use case, making it a promising candidate for communication in next generation BASs.

    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:liu:diva-148570 (URN)10.1109/TII.2018.2844955 (DOI)000443994500032 ()
    Note

    Funding agencies: Vinnova (Swedish Innovation Agency); Norrkoping Fund for Research and Development in Sweden; Swedish Civil Contingencies Agency (MSB) through the Cerces project

    Available from: 2018-06-13 Created: 2018-06-13 Last updated: 2019-08-21
    3. Active Plant Wall for Green Indoor Climate Based on Cloud and Internet of Things
    Open this publication in new window or tab >>Active Plant Wall for Green Indoor Climate Based on Cloud and Internet of Things
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    2018 (English)In: IEEE Access, E-ISSN 2169-3536, Vol. 6, p. 33631-33644Article in journal (Refereed) Published
    Abstract [en]

    An indoor climate is closely related to human health, well-being and comfort. Thus, indoor climate monitoring and management are prevalent in many places, from public offices to residential houses. Our previous research has shown that an active plant wall system can effectively reduce the concentrations of particulate matter and volatile organic compounds and stabilize the carbon dioxide concentration in an indoor environment. However, regular plant care is restricted by geography and can be costly in terms of time and money, which poses a significant challenge to the widespread deployment of plant walls. In this article, we propose a remote monitoring and control system that is specific to the plant walls. The system utilizes the Internet of Things technology and the Azure public cloud platform to automate the management procedure, improve the scalability, enhance user experiences of plant walls, and contribute to a green indoor climate.

    Place, publisher, year, edition, pages
    IEEE, 2018
    National Category
    Computer and Information Sciences
    Identifiers
    urn:nbn:se:liu:diva-148850 (URN)10.1109/ACCESS.2018.2847440 (DOI)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2019-08-21
    4. A Study on Visual Representations for Active Plant Wall Data Analysis
    Open this publication in new window or tab >>A Study on Visual Representations for Active Plant Wall Data Analysis
    Show others...
    2019 (English)In: DATA, E-ISSN 2306-5729, Vol. 4, no 2, article id 74Article in journal (Refereed) Published
    Abstract [en]

    The indoor climate is closely related to human health, well-being, and comfort. Thus, an understanding of the indoor climate is vital. One way to improve the indoor climates is to place an aesthetically pleasing active plant wall in the environment. By collecting data using sensors placed in and around the plant wall both the indoor climate and the status of the plant wall can be monitored and analyzed. This manuscript presents a user study with domain experts in this field with a focus on the representation of such data. The experts explored this data with a Line graph, a Horizon graph, and a Stacked area graph to better understand the status of the active plant wall and the indoor climate. Qualitative measures were collected with Think-aloud protocol and semi-structured interviews. The study resulted in four categories of analysis tasks: Overview, Detail, Perception, and Complexity. The Line graph was found to be preferred for use in providing an overview, and the Horizon graph for detailed analysis, revealing patterns and showing discernible trends, while the Stacked area graph was generally not preferred. Based on these findings, directions for future research are discussed and formulated. The results and future directions of this research can facilitate the analysis of multivariate temporal data, both for domain users and visualization researchers.

    Place, publisher, year, edition, pages
    MDPI, 2019
    Keywords
    visualization; qualitative evaluation; temporal multivariate data; active plant walls, Visualisering; kvalitativ utvärdering; tidsvarierande multivariate data; active plant walls
    National Category
    Computer and Information Sciences
    Identifiers
    urn:nbn:se:liu:diva-157027 (URN)10.3390/data4020074 (DOI)000475303500028 ()
    Available from: 2019-05-23 Created: 2019-05-23 Last updated: 2019-08-21Bibliographically approved
  • 30.
    Holmqvist, Fredrik
    et al.
    Lund Univ, Sweden.
    Kesek, Milos
    Umea Univ Hosp, Sweden.
    Englund, Anders
    Karolinska Inst, Sweden.
    Blomstrom-Lundqvist, Carina
    Uppsala Univ Hosp, Sweden.
    Karlsson, Lars O.
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
    Kenneback, Goran
    Karolinska Univ Hosp, Sweden.
    Poci, Dritan
    Univ Hosp Orebro, Sweden.
    Samo-Ayou, Romeo
    Skaraborg Hosp, Sweden.
    Sigurjonsdottir, Runa
    Sahlgrens Univ Hosp, Sweden.
    Ringborn, Michael
    Blekinge Cty Hosp, Sweden.
    Herczku, Csaba
    Norra Alvsborg Cty Hosp, Sweden.
    Carlson, Jonas
    Lund Univ, Sweden.
    Fengsrud, Espen
    Univ Hosp Orebro, Sweden.
    Tabrizi, Fariborz
    Karolinska Inst, Sweden.
    Hoglund, Niklas
    Umea Univ Hosp, Sweden.
    Lonnerholm, Stefan
    Uppsala Univ Hosp, Sweden.
    Kongstad, Ole
    Lund Univ, Sweden.
    Jonsson, Anders
    Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
    Insulander, Per
    Karolinska Univ Hosp, Sweden.
    A decade of catheter ablation of cardiac arrhythmias in Sweden: ablation practices and outcomes2019In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 40, no 10, p. 820-830Article in journal (Refereed)
    Abstract [en]

    Aims Catheter ablation is considered the treatment of choice for many tachyarrhythmias, but convincing real-world data on efficacy and safety are lacking. Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported. Methods and Results Consecutive patients (18years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26642 patients (5715years, 62% men), undergoing a total of 34428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff-Parkinson-White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7years (interquartile range 2.7-7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (Pamp;lt;0.001). Decreasing procedural times and utilization of fluoroscopy with time, were seen for all arrhythmia types. The rates of repeat ablation differed between ablation types, with the highest repeat ablation seen in AF (41% within 3years). The rate of reported adverse events was low (n=595, 1.7%). Death in the immediate period following ablation was rare (n=116, 0.34%). Conclusion Catheter ablations have shifted towards more complex procedures over the past decade. Fluoroscopy time has markedly decreased and the efficacy of catheter ablation seems to improve for AF.

  • 31.
    Vieillard-Baron, Antoine
    et al.
    Univ Hosp Ambroise Pare, France; Univ Versailles St Quentin En Yvelines, France.
    Millington, S. J.
    Univ Ottawa, Canada.
    Sanfilippo, F.
    Policlin Vittorio Emanuele Univ Hosp, Italy.
    Chew, Michelle
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping (ANOPIVA).
    Diaz-Gomez, J.
    Mayo Clin, FL 32224 USA.
    McLean, A.
    Univ Sydney, Australia.
    Pinsky, M. R.
    Univ Pittsburgh, PA USA.
    Pulido, J.
    US Anesthesia Partners, WA USA.
    Mayo, P.
    Northwell Hlth LIJ NSUH Med Ctr, NY USA.
    Fletcher, N.
    St Georges Univ London, England; Cleveland Clin London, England.
    A decade of progress in critical care echocardiography: a narrative review2019In: Intensive Care Medicine, ISSN 0342-4642, E-ISSN 1432-1238, Vol. 45, no 6, p. 770-788Article, review/survey (Refereed)
    Abstract [en]

    IntroductionThis narrative review focusing on critical care echocardiography (CCE) has been written by a group of experts in the field, with the aim of outlining the state of the art in CCE in the 10 years after its official recognition and definition.ResultsIn the last 10years, CCE has become an essential branch of critical care ultrasonography and has gained general acceptance. Its use, both as a diagnostic tool and for hemodynamic monitoring, has increased markedly, influencing contemporary cardiorespiratory management. Recent studies suggest that the use of CCE may have a positive impact on outcomes. CCE may be used in critically ill patients in many different clinical situations, both in their early evaluation of in the emergency department and during intensive care unit (ICU) admission and stay. CCE has also proven its utility in perioperative settings, as well as in the management of mechanical circulatory support. CCE may be performed with very simple diagnostic objectives. This application, referred to as basic CCE, does not require a high level of training. Advanced CCE, on the other hand, uses ultrasonography for full evaluation of cardiac function and hemodynamics, and requires extensive training, with formal certification now available. Indeed, recent years have seen the creation of worldwide certification in advanced CCE. While transthoracic CCE remains the most commonly used method, the transesophageal route has gained importance, particularly for intubated and ventilated patients.ConclusionCCE is now widely accepted by the critical care community as a valuable tool in the ICU and emergency department, and in perioperative settings.

  • 32.
    Brust, Johannes
    et al.
    University of California, Merced, CA, USA.
    Burdakov, Oleg
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    Erway, Jennifer B.
    Wake Forest University, Winston-Salem, NC, USA.
    Marcia, Roummel F.
    University of California, Merced, CA, USA.
    A dense initialization for limited-memory quasi-Newton methods2019In: Computational Optimization and Applications, ISSN 0926-6003, Vol. 74, no 1, p. 121-142Article in journal (Other academic)
    Abstract [en]

    We consider a family of dense initializations for limited-memory quasi-Newton methods. The proposed initialization exploits an eigendecomposition-based separation of the full space into two complementary subspaces, assigning a different initialization parameter to each subspace. This family of dense initializations is proposed in the context of a limited-memory Broyden–Fletcher–Goldfarb–Shanno (L-BFGS) trust-region method that makes use of a shape-changing norm to define each subproblem. As with L-BFGS methods that traditionally use diagonal initialization, the dense initialization and the sequence of generated quasi-Newton matrices are never explicitly formed. Numerical experiments on the CUTEst test set suggest that this initialization together with the shape-changing trust-region method outperforms other L-BFGS methods for solving general nonconvex unconstrained optimization problems. While this dense initialization is proposed in the context of a special trust-region method, it has broad applications for more general quasi-Newton trust-region and line search methods. In fact, this initialization is suitable for use with any quasi-Newton update that admits a compact representation and, in particular, any member of the Broyden class of updates.

    The full text will be freely available from 2020-05-29 08:00
  • 33.
    Chen, Zhongsheng
    et al.
    Tongji Univ, Peoples R China.
    Zhang, Ying
    Tongji Univ, Peoples R China.
    Peng, Zebo
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Jiang, Jianhui
    Tongji Univ, Peoples R China.
    A Deterministic-Path Routing Algorithm for Tolerating Many Faults on Wafer-Level NoC2019In: 2019 DESIGN, AUTOMATION and TEST IN EUROPE CONFERENCE and EXHIBITION (DATE), IEEE , 2019, p. 1337-1342Conference paper (Refereed)
    Abstract [en]

    Wafer-level NoC has emerged as a promising fabric to further improve supercomputer performance, but this new fabric may suffer from the many-fault problem. This paper presents a deterministic-path routing algorithm for tolerating many faults on wafer-level NoCs. The proposed algorithm generates routing tables using a breadth-first traversal strategy, and stores one routing table in each NoC switch. The switch will then transmit packages according to its routing table online. We use the Tarjan algorithm to dynamically reconfigure the routes to avoid the faulty nodes and develop the deprecated link/node rules to ensure deadlock-free communication of the NoCs. Experimental results demonstrate that the proposed algorithm does not only tolerate the effects of many faults, but also maximizes the available nodes in the reconfigured NoC. The performance of the proposed algorithm in terms of average latency, throughput, and energy consumption is also better than those of the existing solutions.

  • 34.
    Li, Cheng
    et al.
    Chinese Acad Sci, Peoples R China.
    Wang, Chao
    Chinese Acad Sci, Peoples R China; Hebei Univ, Peoples R China.
    Guo, Yiting
    Chinese Acad Sci, Peoples R China.
    Jin, Yingzhi
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Yao, Nannan
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Wu, Yonggang
    Hebei Univ, Peoples R China.
    Zhang, Fengling
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Li, Weiwei
    Chinese Acad Sci, Peoples R China; Beijing Univ Chem Technol, Peoples R China.
    A diketopyrrolopyrrole-based macrocyclic conjugated molecule for organic electronics2019In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 7, no 13, p. 3802-3810Article in journal (Refereed)
    Abstract [en]

    In this work, the first diketopyrrolopyrrole (DPP) based donor-acceptor macrocyclic conjugated molecule was developed and its application in organic electronics was systematically studied. Macrocyclic molecules, as a fragment of armchair carbon nanotubes, have emerged as functional materials in materials chemistry, but the materials are always limited to cycloparaphenylenes. Using the donor-acceptor design strategy that has been widely used in high performance conjugated polymers for macrocyclic molecules, it will significantly broaden their species with tunable optical and electrical properties. Herein, we synthesize a well-defined macrocyclic molecule containing four electron-deficient DPP units alternating with electron-rich thiophenes. The new molecule was found to show high solubility, near-infrared absorption spectra and 3D charge transport properties. The new macrocyclic molecule as an electron acceptor was applied to non-fullerene organic solar cells, exhibiting an initial efficiency of 0.49%, while the linear molecule with a similar backbone only showed a very low efficiency of 0.03%. Our results demonstrate that donor-acceptor macrocyclic conjugated materials have great potential application in organic electronics.

    The full text will be freely available from 2020-02-27 11:26
  • 35.
    Jernnäs, Maria
    et al.
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Centre for Climate Science and Policy Research, CSPR.
    Linnér, Björn-Ola
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Centre for Climate Science and Policy Research, CSPR. Stockholm Environm Inst, Sweden; Univ Oxford, England.
    A discursive cartography of nationally determined contributions to the Paris climate agreement2019In: Global Environmental Change, ISSN 0959-3780, E-ISSN 1872-9495, Vol. 55, p. 73-83Article in journal (Refereed)
    Abstract [en]

    The 2015 Paris Agreement was adopted in a geopolitical context that is very different from the post-Cold War era when the Climate Convention was negotiated. This new global climate deal responds to a more fragmented and multipolar world signified by the rise of major economies in the South. This paper examines the geopolitical landscape in which the Paris Agreement is enacted and implemented. We conduct a discursive analysis of the Nationally Determined Contributions submitted by parties to the Paris Agreement. We ask what policy discourses emerge in these national climate plans, which states cluster around them and how they compare to UNFCCC annex, geographical location, income group, and negotiation coalitions. Our findings suggest that liberal environmentalism retains a strong hold over the political imagination in the post-Paris landscape. However, we see points of diffraction and tensions that might give rise to conflict. While liberal environmentalism is only challenged in Nationally Determined Contributions from the global South, we conclude that conventional geopolitical patterns only partly explain the formation of discourse coalitions. In the Paris Agreements implementation stage discursive struggles are likely to become increasingly prominent. Discourse analysis facilitates understanding of disagreements on the Paris rulebook and the global stocktake.

  • 36.
    Nikkar, Samira
    et al.
    Linköping University, Department of Mathematics, Computational Mathematics. Linköping University, Faculty of Science & Engineering.
    Nordström, Jan
    Linköping University, Department of Mathematics, Computational Mathematics. Linköping University, Faculty of Science & Engineering.
    A dual consistent summation-by-parts formulation for the linearized incompressible Navier-Stokes equations posed on deforming domains2019In: Journal of Computational Physics, ISSN 0021-9991, E-ISSN 1090-2716, Vol. 376, p. 26p. 322-338Article in journal (Refereed)
    Abstract [en]

    In this article, well-posedness and dual consistency of the linearized constant coefficient incompressible Navier–Stokes equations posed on time-dependent spatial domains are studied. To simplify the derivation of the dual problem and improve the accuracy of gradients, the second order formulation is transformed to first order form. Boundary conditions that simultaneously lead to boundedness of the primal and dual problems are derived.Fully discrete finite difference schemes on summation-by-parts form, in combination with the simultaneous approximation technique, are constructed. We prove energy stability and discrete dual consistency and show how to construct the penalty operators such that the scheme automatically adjusts to the variations of the spatial domain. As a result of the aforementioned formulations, stability and discrete dual consistency follow simultaneously.The method is illustrated by considering a deforming time-dependent spatial domain in two dimensions. The numerical calculations are performed using high order operators in space and time. The results corroborate the stability of the scheme and the accuracy of the solution. We also show that linear functionals are superconverging. Additionally, we investigate the convergence of non-linear functionals and the divergence of the solution.

    The full text will be freely available from 2020-10-06 09:11
  • 37.
    Ghazanfari, Amin
    et al.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Cheng, Hei Victor
    Univ Toronto, Canada.
    Björnson, Emil
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Larsson, Erik G
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    A FAIR AND SCALABLE POWER CONTROL SCHEME IN MULTI-CELL MASSIVE MIMO2019In: 2019 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP), IEEE , 2019, p. 4499-4503Conference paper (Refereed)
    Abstract [en]

    This paper studies the transmit power optimization in a multi-cell massive multiple-input multiple-output (MIMO) system. To overcome the scalability issue of network-wide max-min fairness (NW-MMF), we propose a novel power control (PC) scheme. This scheme maximizes the geometric mean (GM) of the per-cell max-min spectral efficiency (SE). To solve this new optimization problem, we prove that it can be rewritten in a convex form and then solved using standard tools. To provide a fair comparison with the available utility functions in the literature, we solve the network-wide proportional fairness (NW-PE) PC as well. The NW-PE focuses on maximizing the sum SE, thereby ignoring fairness, but gives some extra attention to the weakest users. The simulation results highlight the benefits of our model which is balancing between NW-PE and NW-MMF.

  • 38.
    Lanzara, F.
    et al.
    Sapienza Univ, Italy.
    Mazya, Vladimir
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering. RUDN Univ, Russia.
    Schmidt, G.
    Weierstrass Inst Appl Anal and Stochast, Germany.
    A fast solution method for time dependent multidimensional Schrodinger equations2019In: Applicable Analysis, ISSN 0003-6811, E-ISSN 1563-504X, Vol. 98, no 1-2, p. 408-429Article in journal (Refereed)
    Abstract [en]

    In this paper we propose fast solution methods for the Cauchy problem for the multidimensional Schrodinger equation. Our approach is based on the approximation of the data by the basis functions introduced in the theory of approximate approximations. We obtain high-order approximations also in higher dimensions up to a small saturation error, which is negligible in computations, and we prove error estimates in mixed Lebesgue spaces for the inhomogeneous equation. The proposed method is very efficient in high dimensions if the densities allow separated representations. We illustrate the efficiency of the procedure on different examples, up to approximation order 6 and space dimension 200.

  • 39.
    Andersson Granberg, Tobias
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Polishchuk, Tatiana
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Polishchuk, Tatiana
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Schmidt, Christiane
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    A framework for integrated terminal airspace design2019In: Aeronautical Journal, ISSN 0001-9240, Vol. 123, no 1263, p. 567-585Article in journal (Refereed)
    Abstract [en]

    Route planning and airspace sectorisation are two central tasks in air traffic management. Traditionally, the routing and sectorisation problems were considered separately, with aircraft trajectories serving as input to the sectorisation problem and, reciprocally, sectors being part of the input to the path finding algorithms. In this paper we propose a simultaneous design of routes and sectors for a transition airspace. We compare two approaches for this integrated design: one based on mixed integer programming, and one Voronoi-based model that separates potential "hotspots" of controller activity resulting from the terminal routes. We apply our two approaches to the design of Stockholm Terminal Maneuvering Area.

  • 40.
    Tholander, Michael
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Lindberg, Anna
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Arts and Sciences.
    Svensson, Daniel
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Arts and Sciences.
    “A freak that no one can love”: Difficult knowledge in testimonials on school bullying2019In: Research Papers in Education, ISSN 0267-1522, E-ISSN 1470-1146, p. 1-19Article in journal (Refereed)
    Abstract [en]

    This study adopts a testimonial approach to bullying victimisation,and aims to create a deeper understanding of the experiences andeffects of being a bullying target. Four written narratives about beingsubjected to school bullying were analysed according to interpretativephenomenological analysis. From the analysis, four themes wereconstructed, which represented different elements of victimhood: (1)Self-blame in which victims view themselves as the cause of thebullying, (2) Abandonment in which victims describe feelings ofstanding alone in their exposed situation, (3) Turning points inwhich the victims recount a variety of restorative events, and (4)Continued victimhood in which the victims relate how the feeling ofvictimhood and vulnerability continues even though the bullying hasended. In conclusion, school bullying is something that continues toaffect the individual adversely long after it has stopped, althoughstable friendship relations might have a mitigating influence.Through such relations, victimhood can be neutralised and a morepositive self-image develop. Moreover, as numerous other kinds ofvictims emphasise, an essential part of the rehabilitation process is tofinally be able to tell one’s story, to lay bare one’s difficult knowledgeto a wider audience.

  • 41.
    Morgan, Daniel
    et al.
    Stockholm Univ, Sweden.
    Tjärnberg, Andreas
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.
    Nordling, Torbjorn E. M.
    Natl Cheng Kung Univ, Taiwan.
    Sonnhammer, Erik L. L.
    Stockholm Univ, Sweden.
    A generalized framework for controlling FDR in gene regulatory network inference2019In: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 35, no 6, p. 1026-1032Article in journal (Refereed)
    Abstract [en]

    Motivation Inference of gene regulatory networks (GRNs) from perturbation data can give detailed mechanistic insights of a biological system. Many inference methods exist, but the resulting GRN is generally sensitive to the choice of method-specific parameters. Even though the inferred GRN is optimal given the parameters, many links may be wrong or missing if the data is not informative. To make GRN inference reliable, a method is needed to estimate the support of each predicted link as the method parameters are varied. Results To achieve this we have developed a method called nested bootstrapping, which applies a bootstrapping protocol to GRN inference, and by repeated bootstrap runs assesses the stability of the estimated support values. To translate bootstrap support values to false discovery rates we run the same pipeline with shuffled data as input. This provides a general method to control the false discovery rate of GRN inference that can be applied to any setting of inference parameters, noise level, or data properties. We evaluated nested bootstrapping on a simulated dataset spanning a range of such properties, using the LASSO, Least Squares, RNI, GENIE3 and CLR inference methods. An improved inference accuracy was observed in almost all situations. Nested bootstrapping was incorporated into the GeneSPIDER package, which was also used for generating the simulated networks and data, as well as running and analyzing the inferences. Availability and implementation https://bitbucket.org/sonnhammergrni/genespider/src/NB/%2B Methods/NestBoot.m

  • 42.
    Blomvall, Jörgen
    et al.
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, Faculty of Science & Engineering.
    Hagenbjörk, Johan
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, Faculty of Science & Engineering.
    A generic framework for monetary performance attribution2019In: Journal of Banking & Finance, ISSN 0378-4266, E-ISSN 1872-6372, Vol. 105, p. 121-133Article in journal (Refereed)
    Abstract [en]

    We propose a generic framework for performance attribution in monetary terms. Through a second-order Taylor approximation, the changes in portfolio value are attributed to a set of systematic risk factors. By considering two error terms arising from the Taylor approximation, combined with an exact definition of the carry term, we derive a residual-free performance attribution framework, where we exert control over the size of the error terms. The framework incorporates foreign exchange rates and transaction costs, which is illustrated by simulating a European investor acting on the U.S. fixed income market. For the out-of-sample period, we show that we can attribute almost all portfolio value differences and variance using six risk factors obtained from principal component analysis. The results show that our method, in combination with high-quality estimates of risk factors, outperforms other fixed-income attribution models from the literature. (C) 2019 Elsevier B.V. All rights reserved.

  • 43.
    Kharazmi, Mohammad
    et al.
    Uppsala Univ, Sweden.
    Michaelsson, Karl
    Uppsala Univ, Sweden.
    Schilcher, Jörg
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Eriksson, Niclas
    Uppsala Univ, Sweden.
    Melhus, Hakan
    Uppsala Univ, Sweden.
    Wadelius, Mia
    Uppsala Univ, Sweden.
    Hallberg, Par
    Uppsala Univ, Sweden.
    A Genome-Wide Association Study of Bisphosphonate-Associated Atypical Femoral Fracture2019In: Calcified Tissue International, ISSN 0171-967X, E-ISSN 1432-0827, Vol. 105, no 1, p. 51-67Article in journal (Refereed)
    Abstract [en]

    Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug withdrawal. The mechanism behind bisphosphonate-associated atypical femoral fracture is unclear, but a genetic predisposition has been suggested. With the aim to identify common genetic variants that could be used for preemptive genetic testing, we performed a genome-wide association study. Cases were recruited mainly through reports of adverse drug reactions sent to the Swedish Medical Products Agency on a nation-wide basis. We compared atypical femoral fracture cases (n=51) with population-based controls (n=4891), and to reduce the possibility of confounding by indication, we also compared with bisphosphonate-treated controls without a current diagnosis of cancer (n=324). The total number of single-nucleotide polymorphisms after imputation was 7,585,874. A genome-wide significance threshold of pamp;lt;5x10(-8) was used to correct for multiple testing. In addition, we performed candidate gene analyses for a panel of 29 genes previously implicated in atypical femoral fractures (significance threshold of pamp;lt;5.7x10(-6)). Compared with population controls, bisphosphonate-associated atypical femoral fracture was associated with four isolated, uncommon single-nucleotide polymorphisms. When cases were compared with bisphosphonate-treated controls, no statistically significant genome-wide association remained. We conclude that the detected associations were either false positives or related to the underlying disease, i.e., treatment indication. Furthermore, there was no significant association with single-nucleotide polymorphisms in the 29 candidate genes. In conclusion, this study found no evidence of a common genetic predisposition for bisphosphonate-associated atypical femoral fracture. Further studies of larger sample size to identify possible weakly associated genetic traits, as well as whole exome or whole-genome sequencing studies to identify possible rare genetic variation conferring a risk are warranted.

  • 44.
    Fahlström, Andreas
    et al.
    Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden.
    Redebrandt, Henrietta Nittby
    Department of Clinical Sciences Lund, Neurosurgery, Lund University, Skane University Hospital, Lund, Sweden.
    Zeberg, Hugo
    Department of Neuroscience, Karolinska Institutet, Sweden.
    Bartek, Jiri
    Karolinska University Hospital, Stockholm, Sweden; Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
    Bartley, Andreas
    Sahlgrenska University Hospital, Gothenburg, Sweden.
    Tobieson, Lovisa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
    Erkki, Maria
    Umeå University Hospital, Umeå, Sweden.
    Hessington, Amel
    Uppsala University Hospital, Uppsala, Sweden.
    Troberg, Ebba
    Skane University Hospital, Lund, Sweden.
    Mirza, Sadia
    Karolinska University Hospital, Stockholm, Sweden.
    Tsitsopoulos, Parmenion P.
    Uppsala University Hospital, Uppsala, Sweden.
    Marklund, Niklas
    Uppsala University Hospital, Uppsala, Sweden; Skane University Hospital, Lund, Sweden.
    A grading scale for surgically treated patients with spontaneous supratentorial intracerebral hemorrhage: the Surgical Swedish ICH Score2019In: Journal of Neurosurgery, ISSN 0022-3085, E-ISSN 1933-0693, Journal of Neurosurgery JNSArticle in journal (Refereed)
    Abstract [en]

    OBJECTIVE

    The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH).

    METHODS

    A nationwide multicenter study including 401 ICH patients surgically treated by craniotomy and evacuation of a spontaneous supratentorial ICH was conducted between January 1, 2011, and December 31, 2015. All neurosurgical centers in Sweden were included. All medical records and neuroimaging studies were retrospectively reviewed. Independent predictors of 30-day mortality were identified by logistic regression. A risk stratification scale (the Surgical Swedish ICH [SwICH] Score) was developed using weighting of independent predictors based on strength of association.

    RESULTS

    Factors independently associated with 30-day mortality were Glasgow Coma Scale (GCS) score (p = 0.00015), ICH volume ≥ 50 mL (p = 0.031), patient age ≥ 75 years (p = 0.0056), prior myocardial infarction (MI) (p = 0.00081), and type 2 diabetes (p = 0.0093). The Surgical SwICH Score was the sum of individual points assigned as follows: GCS score 15–13 (0 points), 12–5 (1 point), 4–3 (2 points); age ≥ 75 years (1 point); ICH volume ≥ 50 mL (1 point); type 2 diabetes (1 point); prior MI (1 point). Each increase in the Surgical SwICH Score was associated with a progressively increased 30-day mortality (p = 0.0002). No patient with a Surgical SwICH Score of 0 died, whereas the 30-day mortality rates for patients with Surgical SwICH Scores of 1, 2, 3, and 4 were 5%, 12%, 31%, and 58%, respectively.

    CONCLUSIONS

    The Surgical SwICH Score is a predictor of 30-day mortality in patients treated surgically for spontaneous supratentorial ICH. External validation is needed to assess the predictive value as well as the generalizability of the Surgical SwICH Score.

  • 45.
    Mendes-Santos, Cristina
    et al.
    Linköping University, Department of Culture and Communication, Culture and Aesthetics. Linköping University, Faculty of Science & Engineering. Universidade Nova de Lisboa, Lisboa, Portugal.
    Weiderpass, Elisabete
    Institute of Population-Based Cancer Research, Oslo, Norway; University of Tromsø, The Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; University of Helsinki, Helsinki, Finland.
    Santana, Rui
    Universidade Nova de Lisboa, Lisboa, Portugal.
    Andersson, Gerhard
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Otorhinolaryngology. Karolinska Institutet, Stockholm, Sweden.
    A guided internet-delivered individually-tailored ACT-influenced cognitive behavioural intervention to improve psychosocial outcomes in breast cancer survivors (iNNOVBC): Study protocol2019In: Internet Interventions, ISSN 2214-7829, Internet interventions, ISSN 2214-7829, Vol. 17, article id 100236Article in journal (Refereed)
    Abstract [en]

    Background: Internet-delivered interventions can provide remarkable opportunities in addressing breast cancer survivors' unmet support care needs, as they present an effective strategy to improve care coordination and provide access to efficacious, cost-efficient and convenient survivorship care. Nevertheless, research focusing on improving survivors' psychosocial needs using internet-based tools is scarce and its practical implementation is limited.

    Objectives: To study the acceptability, feasibility, efficacy and cost-effectiveness of iNNOVBC, a 10 weeks guided internet-delivered individually-tailored Acceptance and Commitment Therapy (ACT)-influenced cognitive behavioural (CBT) intervention developed to improve mild to moderate anxiety and depression in Breast cancer survivors when compared to treatment as usual (TAU) in a waiting list control group (WLC).

    Methods: A two-arm, parallel, open label, multicentre, waiting list randomized controlled trial will be conducted to investigate the efficacy and cost-effectiveness of INNOVBC. The primary outcomes in this research will be anxiety and depression. Secondary outcomes will include psychological flexibility, fatigue, insomnia, sexual dysfunction and Health Related Quality of Life (HRQoL).

    Ethical approval: This study has been reviewed and approved by Comissão Nacional de Proteção de Dados; Instituto Português de Oncologia do Porto Francisco Gentil; Unidade Local de Saúde de Matosinhos, EPE; Centro Hospitalar de São João and Ordem dos Psicólogos ethical committees.

    Expected results: It is anticipated that iNNOVBC will show to be an efficacious and cost-effective program in improving the outcomes of interest in this study, as opposed to a WLC under TAU. The results of this research will be published in accordance with CONSORT-EHEALTH guidelines.

    Conclusions: This study will inform on the acceptability, feasibility, efficacy and cost-effectiveness of iNNOVBC, in improving psychosocial outcomes in breast cancer survivors when compared to TAU in a WLC. Its conclusions will contribute to understand the idiosyncrasies of designing and implementing internet-delivered interventions in breast cancer survivors.Trial Registration code: INNOVBC (NCT03275727).

  • 46.
    Vaezi, Alireza
    et al.
    Graduate Faculty of Environment, University of Tehran, Enghelab Square, Tehran 1417853111, Iran.
    Ghazban, Fereydoun
    Graduate Faculty of Environment, University of Tehran, Enghelab Square, Tehran 1417853111, Iran.
    Tavakoli, Vahid
    School of Geology, College of Science, University of Tehran, Enghelab Square, Tehran 1417853111, Iran.
    Routh, Joyanto
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Beni, Abdolmajid Naderi
    Iranian National Institute for Oceanography and Atmospheric Sciences, Etemadzadeh St, Tehran 1411813389, Iran.
    Bianchi, Thomas S.
    Department of Geological Sciences, University of Florida, Gainesville, FL 32611, USA.
    Curtis, Jason H.
    Department of Geological Sciences, University of Florida, Gainesville, FL 32611, USA.
    Kylin, Henrik
    Research Unit, Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.
    A Late Pleistocene-Holocene multi-proxy record of climate variability in the Jazmurian playa, southeastern Iran2019In: Palaeogeography, Palaeoclimatology, Palaeoecology, ISSN 0031-0182, E-ISSN 1872-616X, Vol. 514, p. 754-767Article in journal (Refereed)
    Abstract [en]

    We present a multi-proxy record from a 5-m long sediment core from the Jazmurian playa in southeastern Iran to provide insights into globally-recognized major climatic events since the Last Glacial Maximum (LGM). In particular, we examined how variability in the Indian Ocean Summer Monsoon (IOSM) and Mid-Latitude Westerlies (MLW) contribute to distinct environmental changes in this arid to hyper-arid region in the interior of West Asia. While interior West Asia showed cold windy conditions during the LGM and post-LGM, southeast Iran experienced quiescent conditions similar to south Asia. The presence of fine-grained sediments, low magnetic susceptibility, and a decrease in aeolian inputs from ca. 21 to 14 cal kyr BP, suggests that effects of both wind and precipitation were minimal during these quiescent conditions. Increased fluvial inputs, coupled with a low abundance of evaporite minerals in Jazmurian sediments, indicated a greater influence of the IOSM between 14 and 13.2 cal kyr BP. In contrast, the Jazmurian playa was dry and dusty between 13.2 and 11.4 cal kyr BP, as reflected by an increase in aeolian sands, and the presence of evaporite minerals. This was followed by a period of strong IOSM activity during the early Holocene, coinciding with higher fluvial input ca. 11.4 cal kyr BP. The early Holocene in southeast Iran was wetter than other analogs in south Asia because of inputs from both IOSM and MWL. Several intense dry periods with sharp increases in aeolian inputs occurred after the early Holocene, due to the southward migration of the Intertropical Convergence Zone. Precipitation sources changed from a monsoon-dominated regime to one influenced mainly by the MLW during the late-Holocene. These results show that palaeoenvironmental changes in the Jazmurian playa, located at the border of IOSM and MLW zones, were primarily governed by global and regional paleoclimatic changes.

  • 47.
    Lindgren, Petter
    et al.
    Department of Biological Agents, Division of CBRN Defence and Security, Swedish Defence Research Agency (FOI), Uemå, Sweden.
    Myrtennäs, Kerstin
    Department of Biological Agents, Division of CBRN Defence and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden..
    Forsman, Mats
    Department of Biological Agents, Division of CBRN Defence and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden.
    Johansson, Anders
    Department of Clinical Microbiology and Molecular Infection Medicine Sweden (MIMS), Umeå University, Sweden.
    Stenberg, Per
    Department of Biological Agents, Division of CBRN Defence and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden and Department of Ecology and Environmental Science (EMG), Umeå University, Sweden.
    Nordgaard, Anders
    Linköping University, Department of Computer and Information Science, The Division of Statistics and Machine Learning. Linköping University, Faculty of Arts and Sciences. Swedish Police Auhtority, National Forensic Centre (NFC).
    Ahlinder, Jon
    Department of Biological Agents, Division of CBRN Defence and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden.
    A likelihood ratio-based approach for improved source attribution in microbiological forensic investigations2019In: Forensic Science International, ISSN 0379-0738, E-ISSN 1872-6283, Forensic Science International, ISSN 0379-0738, Vol. 302, article id 109869Article in journal (Refereed)
    Abstract [en]

    A common objective in microbial forensic investigations is to identify the origin of a recovered pathogenic bacterium by DNA sequencing. However, there is currently no consensus about how degrees of belief in such origin hypotheses should be quantified, interpreted, and communicated to wider audiences. To fill this gap, we have developed a concept based on calculating probabilistic evidential values for microbial forensic hypotheses. The likelihood-ratio method underpinning this concept is widely used in other forensic fields, such as human DNA matching, where results are readily interpretable and have been successfully communicated in juridical hearings. The concept was applied to two case scenarios of interest in microbial forensics: (1) identifying source cultures among series of very similar cultures generated by parallel serial passage of the Tier 1 pathogen Francisella tularensis, and (2) finding the production facilities of strains isolated in a real disease outbreak caused by the human pathogen Listeria monocytogenes. Evidence values for the studied hypotheses were computed based on signatures derived from whole genome sequencing data, including deep-sequenced low-frequency variants and structural variants such as duplications and deletions acquired during serial passages. In the F. tularensis case study, we were able to correctly assign fictive evidence samples to the correct culture batches of origin on the basis of structural variant data. By setting up relevant hypotheses and using data on cultivated batch sources to define the reference populations under each hypothesis, evidential values could be calculated. The results show that extremely similar strains can be separated on the basis of amplified mutational patterns identified by high-throughput sequencing. In the L. monocytogenes scenario, analyses of whole genome sequence data conclusively assigned the clinical samples to specific sources of origin, and conclusions were formulated to facilitate communication of the findings. Taken together, these findings demonstrate the potential of using bacterial whole genome sequencing data, including data on both low frequency SNP signatures and structural variants, to calculate evidence values that facilitate interpretation and communication of the results. The concept could be applied in diverse scenarios, including both epidemiological and forensic source tracking of bacterial infectious disease outbreaks.

  • 48.
    Eriksson, Robert
    et al.
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.
    Moverare, Johan
    Linköping University, Department of Management and Engineering, Engineering Materials. Linköping University, Faculty of Science & Engineering.
    Chen, Zhe
    Linköping University, Department of Management and Engineering, Engineering Materials. Linköping University, Faculty of Science & Engineering.
    A low cycle fatigue life model for a shot peened gas turbine disc alloy2019In: International Journal of Fatigue, ISSN 0142-1123, E-ISSN 1879-3452, Vol. 124, p. 34-41Article in journal (Refereed)
    Abstract [en]

    Turbine disks in gas turbines are subjected to cyclic load at high temperature, making, especially the fir tree type blade attachments, susceptible to fatigue. Shot peening of the fir tree attachments may be used to increase the fatigue life by introducing compressive residual stresses. In the current study, both polished and shot peened notched specimens made from alloy 718 were subjected to low cycle fatigue at 450-550 degrees C. The shot peening generally increased the fatigue life, although the effect diminished for high loads. It was shown that the effect of shot peening could be handled as mean stress effects in a life model based on a Smith-Watson-Topper (SWT) type parameter, sigma(max)Delta epsilon/2. A material model which captured the mean stress was set up to get the SWT parameter at the notch root. It was shown that thermal relaxation of residual stresses and initial strain hardening from cold work could be excluded from the finite element analysis used to establish the mean stress; this since the plasticity in the first cycle dominated the plastic deformation of the specimen. Overall, the SWT-based life model worked satisfactorily. However, the prediction of correct mean stresses at 550 degrees C proved somewhat difficult as the degree of mean stress relaxation at this temperature varies widely in available literature data.

  • 49.
    Jakobsson, Anders
    et al.
    Huawei Technologies Sweden AB, Kista, Sweden.
    Serban, Adriana
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Gong, Shaofang
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    A Low Noise RC-based Phase Interpolator in 16-nm CMOS2019In: IEEE Transactions on Circuits and Systems - II - Express Briefs, ISSN 1549-7747, E-ISSN 1558-3791, Vol. 66, no 1Article in journal (Refereed)
    Abstract [en]

    This paper describes a passive analog phase interpolator, utilizing a switched RC-network. The proposed circuit eliminates the current sources in a phase interpolator based on constant-slope charging. By eliminating the current source, the noise is significantly reduced due to the reduction in thermal and flicker noise. The phase interpolator has a resolution of 6 bits and is implemented in a 16-nm CMOS process. The maximum differential non-linearity is measured to be 0.1 LSBs at a 192 ps input time delta. The circuit draws 0.2 mW from a 0.8 V supply, and occupies 0.004 mm2.

  • 50.
    Karlsson, Emil
    et al.
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering. Saab AB, SE-581 88 Linköping.
    Rönnberg, Elina
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering. Saab AB, SE-581 88 Linköping.
    Stenberg, Andreas
    Saab AB, SE-581 88 Linköping.
    Uppman, Hannes
    Saab AB, SE-581 88 Linköping.
    A matheuristic approach to large-scale avionic scheduling2019Report (Other academic)
    Abstract [en]

    Pre-runtime scheduling of avionic systems is used to ensure that the systems provide the desired functionality at the correct time. This paper considers scheduling of an integrated modular avionic system which from a more general perspective can be seen as a multiprocessor scheduling problem that includes a communication network. The addressed system is practically relevant and the computational evaluations are made on large-scale instances developed together with the industrial partner Saab. A subset of the instances is made publicly available.

    Our contribution is a matheuristic for solving these large-scale instances and it is obtained by improving the model formulations used in a previously suggested constraint generation procedure and by including an adaptive large neighbourhood search to extend it into a matheuristic. Characteristics of our adaptive large neighbourhood search are that it is made over both discrete and continuous variables and that it needs to balance the search for feasibility and profitable objective value. The repair operation is to apply a mixed-integer programming solver on a model where most of the constraints are treated as soft and a violation of them is instead penalised in the objective function. The largest solved instance, with respect to the number of tasks, has 45 988 tasks and 2 011 communication messages.

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