liu.seSearch for publications in DiVA
Change search
Refine search result
1234567 1 - 50 of 18556
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Li, Jia
    Linköping University, Department of Electrical Engineering.
    10G GPON Management System Study and Implementation2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis includes the GPON management system concept study and implementation work to translate the command line interface management mechanism to a user friendly GUI (graphic user interface). The original system was developed in C program with a client-server structure. The new system retains the same communication structure and protocol interface between the OLT PON card and user workstations. On the workstation side, a new GUI management client application is developed in Java to offer the similar functionalities as the original one, and a totally new graphic real-time system traffic statistics function is integrated to make it easier for user to monitor system traffic information in real time.

     

    The main object of this project is to study the GPON specifications, and understand GPON system working procedure and traffic transmission principle. On the other hand, ‘original system management application’ study is necessary including third party documentation reading and C code understanding. This study has resulted in the development of a new application in Java with third party user libraries and plug-ins. This new application has been tested using basic function tests executed in the GPON lab environment.

    Download full text (pdf)
    FULLTEXT01
  • 2.
    Lang, Hauke
    et al.
    Univ Med Mainz, Germany.
    de Santibanes, Eduardo
    Italian Hosp Buenos Aires, Argentina.
    Schlitt, Hans J.
    Univ Regensburg, Germany.
    Malago, Massimo
    UCL, England.
    van Gulik, Thomas
    Univ Amsterdam, Netherlands.
    Machado, Marcel A.
    Univ Sao Paulo, Brazil.
    Jovine, Elio
    Maggiore Hosp, Italy.
    Heinrich, Stefan
    Univ Med Mainz, Germany.
    Ettorre, Giuseppe Maria
    Camillo Hosp, Italy.
    Chan, Albert
    Univ Hong Kong, Peoples R China.
    Hernandez-Alejandro, Roberto
    Univ Rochester, NY USA.
    Campos, Ricardo Robles
    Virgen de la Arrixaca Clin and Univ Hosp, Spain.
    Sandström, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Linecker, Michael
    Univ Hosp Zurich, Switzerland.
    Clavien, Pierre-Alain
    Univ Hosp Zurich, Switzerland.
    10th Anniversary of ALPPS-Lessons Learned and quo Vadis2019In: Annals of Surgery, ISSN 0003-4932, E-ISSN 1528-1140, Vol. 269, no 1, p. 114-119Article in journal (Refereed)
    Abstract [en]

    Objective: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications and clinical scenarios, leading to steady improvements in safety. This report presents the current status of ALPPS. Summary Background Data: ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety and oncologic benefits. Methods: During the 12th biennial congress of the European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th anniversary of ALPP" was held to discuss indications, management, mechanisms of regeneration, as well as pitfalls of this novel technique. The aim of the meeting was to make an inventory of what has been achieved and what remains unclear in ALPPS. Results: Precise knowledge of liver anatomy and its variations is paramount for success in ALPPS. Technical modifications, mainly less invasive approaches like partial, mini- or laparoscopic ALPPS, mostly aiming at minimizing the extensiveness of the first-stage procedure, are associated with improved safety. In fibrotic/cirrhotic livers the degree of future liver remnant hypertrophy after ALPPS appears some less than that in noncirrhotic. Recent data from the only prospective randomized controlled trial confirmed significant higher resection rates in ALPPS with similar peri-operative morbidity and mortality rates compared with conventional 2-stage hepatectomy including portal vein embolization. ALPPS is effective reliably even after failure of portal vein embolization. Conclusions: Although ALPPS is now an established 2-stage hepatectomy additional data are warranted to further refine indication and technical aspects. Long-term oncological outcome results are needed to establish the place of ALPPS in patients with initially nonresectable liver tumors.

  • 3.
    Ahmed Aamir, Syed
    et al.
    University of Bielefeld, Germany .
    Angelov, Pavel
    AnaCatum Design AB, Linkoping, Sweden .
    Wikner, Jacob
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    1.2-V Analog Interface for a 300-MSps HD Video Digitizer in Core 65-nm CMOS2014In: IEEE Transactions on Very Large Scale Integration (vlsi) Systems, ISSN 1063-8210, E-ISSN 1557-9999, Vol. 22, no 4, p. 888-898Article in journal (Refereed)
    Abstract [en]

    This paper describes the front-end of a fully integrated analog interface for 300 MSps, high-definition video digitizers in a system on-chip environment. The analog interface is implemented in a 1.2 V, 65-nm digital CMOS process and the design minimizes the number of power domains using core transistors only. Each analog video receiver channel contains an integrated multiplexer with a current-mode dc-clamp, a programmable gain amplifier (PGA) and a pseudo second-order RC low-pass filter. The digital charge-pump clamp is integrated with low-voltage bootstrapped tee-switches inside the multiplexer, while restoring the dc component of ac-coupled inputs. The PGA contains a four-stage fully symmetric pseudo-differential amplifier with common-mode feedforward and inherent common-mode feedback, utilized in a closed loop capacitive feedback configuration. The amplifier features offset cancellation during the horizontal blanking. The video interface is evaluated using a unique test signal over a range of video formats for INL+/DNL+, INL-/DNL-. The 0.07-0.39 mV INL, 2-70 mu V DNL, and 66-74 dB of SFDR, enable us to target various formats for 9-12 bit Low-voltage digitizers.

  • 4.
    Holmbom, Martin
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
    Giske, Christian G.
    Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.; Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden..
    Fredrikson, Mats
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Östholm Balkhed, Åse
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
    Claesson, Carina
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Nilsson, Lennart E
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Hoffmann, Mikael
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Hanberger, Håkan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
    14-Year Survey in a Swedish County Reveals a Pronounced Increase in Bloodstream Infections (BSI). Comorbidity: An Independent Risk Factor for Both BSI and Mortality2016In: PLOS ONE, E-ISSN 1932-6203, Vol. 11, no 11Article in journal (Refereed)
    Abstract [en]

    Objectives: we assessed the incidence, risk factors and outcome of BSI over a 14-year period (2000-2013) in a Swedish county.

    Methods: retrospective cohort study on culture confirmed BSI among patients in the county of Östergötland, Sweden, with approximately 440,000 inhabitants. A BSI was defined as either community-onset BSI (CO-BSI) or hospital-acquired BSI (HA-BSI).

    Results: of a total of 11,480 BSIs, 67% were CO-BSI and 33% HA-BSI. The incidence of BSI increased by 64% from 945 to 1,546 per 100,000 hospital admissions per year during the study period. The most prominent increase, 83% was observed within the CO-BSI cohort whilst HA-BSI increased by 32%. Prescriptions of antibiotics in outpatient care decreased with 24% from 422 to 322 prescriptions dispensed/1,000 inhabitants/year, whereas antibiotics prescribed in hospital increased by 67% (from 424 to 709 DDD per 1,000 days of care). The overall 30-day mortality for HA-BSIs was 17.2%, compared to 10.6% for CO-BSIs, with an average yearly increase per 100,000 hospital admissions of 2 and 5% respectively. The proportion of patients with one or more comorbidities, increased from 20.8 to 55.3%. In multivariate analyses, risk factors for mortality within 30 days were: HA-BSI (2.22); two or more comorbidities (1.89); single comorbidity (1.56); CO-BSI (1.21); male (1.05); and high age (1.04).

    Conclusion: this survey revealed an alarming increase in the incidence of BSI over the 14-year study period. Interventions to decrease BSI in general should be considered together with robust antibiotic stewardship programmes to avoid both over- and underuse of antibiotics.

    Download full text (pdf)
    fulltext
  • 5.
    Browaldh, Nanna
    et al.
    Karolinska University Hospital.
    Friberg, Danielle
    Karolinska University Hospital.
    Svanborg, Eva
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Neurophysiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Neurophysiology UHL.
    Nerfeldt, Pia
    Karolinska University Hospital.
    15-year efficacy of uvulopalatopharyngoplasty based on objective and subjective data2011In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 131, no 12, p. 1303-1310Article in journal (Refereed)
    Abstract [en]

    Conclusions: This follow-up showed a stable and significant decrease in median oxygen desaturation index 4% (ODI(4)) values over the years. Approximately two-thirds of the patients fulfilled the success criteria (ODI4 reduction of 50% and andlt;20) after 15 years. A majority had improved/cured excessive daytime sleepiness (EDS) and were satisfied. No increased mortality rate was seen. Objectives: To evaluate sleep apnoea recordings and symptoms in patients with obstructive sleep apnoea syndrome 15 years after uvulopalatopharyngoplasty (UPPP) compared to baseline and previous follow-ups. Methods: This was a non-randomized, prospective intervention study on 50 patients who underwent UPPP during 1985-88. Their initial median age was 49 years (range 38-71) and ODI4 was 26.5 (4-82). Results: In all, 13 patients had died; 26 patients underwent sleep apnoea recordings. Median ODI4 had decreased from 26.5 (range 4-82) to 8.5 (0-60), p andlt; 0.01, a mean reduction of 52%; 65% of patients achieved the success criteria. One-third was objectively categorized as non-snorers. Median body mass index was unchanged. The questionnaires were answered by 32 of 37 patients; 88% reported improved or cured EDS and 78% were satisfied. Pharyngeal disturbances ratings were low. The standardized mortality rate did not differ from the general Swedish population.

    Download full text (pdf)
    fulltext
  • 6.
    Kallstrom, Ann-Christine
    et al.
    Helsingborg Hospital.
    Salme, Rebecka
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Ryden, Lisa
    Lund University.
    Nordenskjöld, Bo
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    Jonsson, Per-Ebbe
    Helsingborg Hospital.
    Stål, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    17 beta-Hydroxysteroid dehydrogenase type 1 as predictor of tamoxifen response in premenopausal breast cancer2010In: EUROPEAN JOURNAL OF CANCER, ISSN 0959-8049, Vol. 46, no 5, p. 892-900Article in journal (Refereed)
    Abstract [en]

    17 beta-Hydroxysteroid dehydrogenases (17HSDs) are involved in the local regulation of sex steroids. 17HSD1 converts oestrone (El) to the more potent oestradiol (E2) and 17HSD2 catalyses the reverse reaction. The aim of this study was to investigate the expression of these enzymes in premenopausal breast cancers and to analyse if they have any prognostic or tamoxifen predictive value. Premenopausal patients with invasive breast cancer, stage II (UICC), were randomised to either 2 years of adjuvant tamoxifen (n = 276) or no tamoxifen (n = 288). The median follow-up was 13.9 years (range 10.5-17.5). The expression of 17HSD1 and 17HSD2 was analysed with immunohistochemistry using tissue microarrays. The enzyme expression level (-/+/++/+++) was successfully determined in 396 and 373 tumours, respectively. Women with hormone-receptor positive tumours, with low levels (-/+/++) of 17HSD1, had a 43% reduced risk of recurrence, when treated with tamoxifen (Hazard Ratio (HR) = 0.57; 95% confidence interval (CI), 0.37-0.86; p = 0.0086). On the other hand high expression (+++) of 17HSD1 was associated with no significant difference between the two treatment arms (HR = 0.91; 95% CI, 0.43-1.95; p = 0.82). The interaction between 17HSD1 and tamoxifen was significant during the first 5 years of follow-up (p = 0.023). In the cohort of systemically untreated patients no prognostic importance was observed for 17HSD1. We found no predictive or prognostic value for 17HSD2. This is the first report of 17HSD1 in a cohort of premenopausal women with breast cancer randomised to tamoxifen. Our data suggest that 17HSD1 might be a predictive factor in this group of patients.

  • 7.
    Jansson , Agneta
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences.
    17Beta-hydroxysteroid dehydrogenase enzymes and breast cancer2009In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760 , Vol. 114, no 1-2, p. 64-67Article in journal (Refereed)
    Abstract [en]

    Sex steroids play an important role in the development and differentiation in several tissues. Biologically active hormones that are locally converted in endocrine organs in the tissue where they exert their effects without release into extracellular space is a field of endocrinology that has been called intracrinology. In pre-menopausal women the ovary is the main source of estrogens, but in post-menopausal women the estrogen production as main site of synthesis moves to peripheral tissues and almost all of the sex steroids are synthesised from precursors of adrenal origin. In breast cancer 60-80% of the tumors express high levels of oestrogen receptor (ER) alpha which gives estrogen a proliferative effect. Breast tumors tend to have a higher intratumoral estrogen concentration than normal breast tissue and plasma, and in situ synthesis and the metabolism of estrogens is believed to be of great importance for the development and progression of the disease. The activity of estrogen metabolizing enzymes in breast are mainly aromatase, estrone sulfatases and 17HSD enzymes. 17HSD1 and 17HSD2 are the family members known to be of main importance in breast cancer. High expression of 17HSD1 has been associated to poor prognosis in breast cancer and late relapse among patients with ER-positive tumors. One of the mechanisms behind high 17HSD1 expression is gene amplification. Low or absent expression of 17HSD2 is associated to decreased survival in ER-positive breast cancer. 17HSD14 is one of the latest discovered 17HSD enzymes, transfection of 17HSD14 in human breast cancer cells significantly decreased the levels of estradiol in the culture medium. Low expression of 17HSD14 mRNA expression in breast cancer was correlated to decreased survival.

    The understanding of intratumoral synthesis of sex steroids in breast cancer is crucial to understand the disease both in pre- and post-menopausal women. Further studies are desirable to state the direct role of these enzymes in breast cancer and which patients that may benefit from new therapeutic strategies targeting 17HSD enzymes. The new inhibitors targeting 17HSD1 have shown promising results in preclinical studies to have clinical potential in the future.

  • 8.
    Sivik, Tove
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    Gunnarsson, Cecilia
    Linköping University, Department of Clinical and Experimental Medicine, Medical Genetics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Fornander, Tommy
    Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
    Nordenskjöld, Bo
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Skoog, Lambert
    Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
    Stål, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Jansson, Agneta
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    17β-hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer2012In: PLOS ONE, E-ISSN 1932-6203, Vol. 7, no 7, p. e40568-Article in journal (Refereed)
    Abstract [en]

    Introduction: 17β-hydroxysteroid dehydrogenases (17βHSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was undertaken in order to evaluate implications of 17βHSD14 in breast cancer, measuring 17βHSD14 protein expression in breast tumours.

    Methods: An antibody targeting the 17βHSD14 antigen was generated and validated using HSD17B14-transfected cells and a peptide-neutralising assay. Tissue microarrays with tumours from 912 post-menopausal women diagnosed with lymph node-negative breast cancer, and randomised to adjuvant tamoxifen or no endocrine treatment, were analysed for 17βHSD14 protein expression with immunohistochemistry.

    Results: Results were obtained from 847 tumours. Patients with oestrogen positive tumours with high 17βHSD14 expression had fewer local recurrences when treated with tamoxifen (HR 0.38; 95% C.I. 0.19–0.77, p = 0.007) compared to patients with lower tumoural 17βHSD14 expression, for whom tamoxifen did not reduce the number of local recurrences (HR 1.19; 95% C.I. 0.54–2.59; p = 0.66). No prognostic importance of 17βHSD14 was seen for systemically untreated patients.

    Conclusions: Using a highly specific validated antibody for immunohistochemical analysis of a large number of breast tumours, we have shown that tumoural expression levels of 17βHSD14 can predict the outcome of adjuvant tamoxifen treatment in terms of local recurrence-free survival in patients with lymph node-negative ER+ breast cancer. The results need be verified to confirm any clinical relevance.

    Download full text (pdf)
    fulltext
  • 9.
    Wijma, Barbro
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Gender and medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Sjögren, Berit
    Karolinska sjukhuset, Stockholm.
    1900-talet och psykosocial obstetrik, gynekologi och sexologi2004In: Svensk kvinnosjukvård under ett sekel: [1904-2004 : jubileumsskrift] / [ed] Bo Lindberg, Stockholm: SFOG , 2004, p. -248Chapter in book (Other academic)
  • 10.
    Jantunen, Liisa
    et al.
    Environment Canada, Canada.
    Wong, Fiona
    Stockholm University.
    Gawor, Anya
    Environment Canada.
    Kylin, Henrik
    Linköping University, The Tema Institute, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Helm, Paul
    Ontario Ministry of the Environment, Canada.
    Stern, Gary
    University of Manitoba, Canada.
    Strachan, William
    Environment Canada, Canada.
    Burniston, Deborah
    Environment Canada, Canada.
    Bidleman, Terry
    Umeå University.
    20 Years of Air-Water Gas Exchange Observations for Pesticides in the Western Arctic Ocean2015In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, no 23, p. 13844-13852Article in journal (Refereed)
    Abstract [en]

    The Arctic has been contaminated by legacy organochlorine pesticides (OCPs) and currently used pesticides (CUPs) through atmospheric transport and oceanic currents. Here we report the time trends and air−water exchange of OCPs and CUPs from research expeditions conducted between 1993 and 2013. Compounds determined in both air and water were trans- and cis-chlordanes (TC, CC), trans- and cis-nonachlors (TN, CN), heptachlor exo-epoxide (HEPX), dieldrin (DIEL), chlorobornanes (ΣCHBs and toxaphene), dacthal (DAC), endosulfans and metabolite endosulfan sulfate (ENDO-I, ENDO-II, and ENDO SUL), chlorothalonil (CHT), chlorpyrifos (CPF), and trifluralin (TFN). Pentachloronitrobenzene (PCNB and quintozene) and its soil metabolite pentachlorothianisole (PCTA) were also found in air. Concentrations of most OCPs declined in surface water, whereas some CUPs increased (ENDO-I, CHT, and TFN) or showed no significant change (CPF and DAC), and most compounds declined in air. Chlordane compound fractions TC/(TC + CC) and TC/(TC + CC + TN) decreased in water and air, while CC/(TC + CC + TN) increased. TN/(TC + CC + TN) also increased in air and slightly, but not significantly, in water. These changes suggest selective removal of more labile TC and/or a shift in chlordane sources. Water−air fugacity ratios indicated net volatilization (FR > 1.0) or near equilibrium (FR not significantly different from 1.0) for most OCPs but net deposition (FR < 1.0) for ΣCHBs. Net deposition was shown for ENDO-I on all expeditions, while the net exchange direction of other CUPs varied. Understanding the processes and current state of air−surface exchange helps to interpret environmental exposure and evaluate the effectiveness of international protocols and provides insights for the environmental fate of new and emerging chemicals.

    Download full text (pdf)
    fulltext
  • 11.
    du Bois, A
    et al.
    Department of Gynecology & Gynecologic Oncology, Wiesbaden, Germany..
    Quinn, M
    Thigpen, T
    Vermorken, J
    Åvall-Lundqvist, Elisabeth
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Bookman, M
    Bowtell, D
    Brady, M
    Casado, A
    Cervantes, A
    Eisenhauer, E
    Friedlaender, M
    Fujiwara, K
    Grenman, S
    Guastalla, J P
    Harper, P
    Hogberg, T
    Kaye, S
    Kitchener, H
    Kristensen, G
    Mannel, R
    Meier, W
    Miller, B
    Neijt, J P
    Oza, A
    Ozols, R
    Parmar, M
    Pecorelli, S
    Pfisterer, J
    Poveda, A
    Provencher, D
    Pujade-Lauraine, E
    Randall, M
    Rochon, J
    Rustin, G
    Sagae, S
    Stehman, F
    Stuart, G
    Trimble, E
    Vasey, P
    Vergote, I
    Verheijen, R
    Wagner, U
    2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004).2005In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 16, no 8, p. viii7-viii12Article in journal (Refereed)
  • 12.
    Horner, Patrick J
    et al.
    School of Social and Community Medicine, University of Bristol, UK.
    Karla, Blee
    Bristol Sexual Health Centre, University Hospitals Bristol NHS Foundation Trust, UK.
    Falk, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in West Östergötland, Research & Development Unit in Local Health Care.
    van der Meijden, W
    Department of Dermatology, New Cross Hospital, UK..
    Moi, H.
    Olafia Clinic, Oslo University Hospital, Institute of Medicine, University of Oslo, Norway.
    2016 European Guideline on the management of non-gonococcal urethritis2016In: International Journal of STD and AIDS (London), ISSN 0956-4624, E-ISSN 1758-1052, Vol. 27, no 11, p. 928-937Article in journal (Refereed)
    Abstract [en]

    We present the updated International Union against Sexually Transmitted Infections guideline for the management of non-gonococcal urethritis in men. This guideline recommends confirmation of urethritis in symptomatic men before starting treatment. It does not recommend testing asymptomatic men for the presence of urethritis. All men with urethritis should be tested for Chlamydia trachomatis and Neisseria gonorrhoeae and ideally M. genitalium using a NAAT as this is highly likely to improve clinical outcomes. If a NAAT is positive for gonorrhoea, a culture should be performed before treatment. In view of the increasing evidence that azithromycin 1 g may result in the development of antimicrobial resistance in Mycoplasma genitalium azithromycin 1 g is no longer recommended as first line therapy, which should be doxycycline 100 mg bd for 7 days. If azithromycin is to be prescribed an extended of 500 mg, then 250 mg daily for 4 days is to be preferred over 1 g stat. In men with persistent NGU, M. genitalium NAAT testing is recommended if not previously undertaken, as is Trichomonas vaginalis NAAT testing in populations where T. vaginalis is detectable in >2% of symptomatic women.

  • 13.
    Ha, Soonhoi
    et al.
    Seoul Natl Univ, South Korea.
    Eles, Petru Ion
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    2018 Embedded Systems Week (ESWEEK) in Torino2019In: IEEE design & test, ISSN 2168-2356, E-ISSN 2168-2364, Vol. 36, no 1, p. 68-69Article in journal (Other academic)
    Abstract [en]

    n/a

  • 14.
    Asa, Sylvia
    et al.
    Department of Pathology, University Health Network, Toronto, Ontario, Canada.
    Bodén, Anna
    Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.
    Treanor, Darren
    University of Leeds, and Leeds Teaching Hospitals NHS Trust Leeds, UK.
    Jarkman, Sofia
    Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.
    Lundström, Claes
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Pantatnowitz, Liron
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, USA.
    2020 vision of digital pathology in action2019In: Journal of Pathology Informatics, ISSN 2229-5089, E-ISSN 2153-3539, Vol. 10, no 27Article in journal (Other academic)
    Download full text (pdf)
    fulltext
  • 15.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    20:e internationella audiologikongressen. Intressanta resultat om binaural hörsel.1991In: Audio Nytt, ISSN 0347-6308, Vol. 18, p. 30-31Article in journal (Other (popular science, discussion, etc.))
  • 16.
    Moloney, Maria
    et al.
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Farnebo, Simon
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Adolfsson, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    20-Year outcome of TFCC repairs2018In: Journal of Plastic Surgery and Hand Surgery, ISSN 2000-656X, E-ISSN 2000-6764, Vol. 52, no 3, p. 193-197Article in journal (Refereed)
    Abstract [en]

    The aims of this study were to investigate the functional result and rate of osteoarthritis 15-25 years after a TFCC-repair. Forty-seven patients completed the questionnaire Patient Rated Wrist Evaluation (PRWE), and 43 had new X-rays. Fifty-seven percent had a simultaneous arthroscopy. Sixteen patients had later additional surgery to the wrist, of these eight had a reoperation of the TFCC-injury due to recurrent instability. Radiographs showed that 17.5% had developed radiocarpal osteoarthritis and 34% osteoarthritis in the distal radioulnar joint. The median PRWE result was 22.5. Patients with radiocarpal osteoarthritis and patients who had additional surgery had significantly worse scores. Patients who had undergone arthroscopy significantly less often had developed radiocarpal osteoarthritis. The result is acceptable but not impressive and efforts should be made to diagnose these injuries early and also diagnose associated injuries, advisably by arthroscopy.

  • 17.
    Tondel, Martin
    et al.
    University of Gothenburg.
    Murgia, Nicola
    University of Perugia.
    Persson, Bodil
    Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Occupational and Environmental Medicine Centre.
    Lindh, Jonas
    Ryhov County Hospital.
    Vrethem, Magnus
    Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Fredrikson, Mats
    Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences.
    2,5-Hexanedione in the General Population: Environmental Exposure or Endogenous Production? in EPIDEMIOLOGY, vol 22, issue 1, pp S34-S352011In: EPIDEMIOLOGY, Williams and Wilkins , 2011, Vol. 22, no 1, p. S34-S35Conference paper (Refereed)
    Abstract [en]

    n/a

  • 18.
    Hallert, Eva
    et al.
    Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Rehabilitation Center. Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics.
    Husberg, Magnus
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Skogh, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.
    28-joint count disease activity score at 3 months after diagnosis of early rheumatoid arthritis is strongly associated with direct and indirect costs over the following 4 years: the Swedish TIRA project2011In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 50, no 7, p. 1259-1267Article in journal (Refereed)
    Abstract [en]

    Methods. Three-hundred and twenty patients with early (1 year) RA were assessed at regular intervals. Clinical and laboratory data were collected and patients reported health-care utilization and number of days lost from work. At 3-month follow-up, patients were divided into two groups according to disease activity, using DAS-28 with a cut-off level at 3.2. Direct and indirect costs and EuroQol-5D over the following 4 years were compared between the groups. Multivariate regression models were used to control for possible covariates. Results. Three months after diagnosis, a DAS-28 level of epsilon 3.2 was associated with high direct and indirect costs over the following 4 years. Patients with DAS-28 epsilon 3.2 at 3-month follow-up had more visits to physician, physiotherapist, occupational therapist and nurse, higher drug costs, more days in hospital and more extensive surgery compared with patients with 3-month DAS-28 less than 3.2. Number of days lost from work due to sick leave and permanent work disability was also higher in this group. The effect of disease activity on health-related quality of life was highly significant. In regression models, DAS-28 at 3-month follow-up was significantly associated with costs over the following years. Conclusions. Three months after diagnosis, DAS-28 is an important prognostic marker regarding health-care utilization and costs. Achieving remission or low disease activity 3 months after diagnosis is likely to decrease morbidity, increase quality of life and save costs for the patient and for society over the following years.

    Download full text (pdf)
    fulltext
  • 19. Order onlineBuy this publication >>
    Abedini, Fereshteh
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    2D and 3D Halftoning for Appearance Reproduction2023Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The appearance of an object is determined by its chromatic and geometric qualities in its surrounding environment using four optical parameters: color, gloss, translucency, and surface texture. Reconstructing the appearance of objects is of great importance in many applications, including creative industries, packaging, fine-art reproduction, medical simulation, and prosthesis-making. Printers are reproduction devices capable of replicating objects’ appearance in 2D and 3D forms. With the introduction of new printing technologies, new inks and materials, and demands for innovative applications, creating accurate reproduction of the desired visual appearance has become challenging. Thus, the appearance reproduction workflow requires improvements and adaptations. 

    Accurate color reproduction is a critical quality measure in reproducing the desired appearance in any printing process. However, printers are devices with a limited number of inks that can either print a dot or leave it blank at a specific position on a substrate; hence, to reproduce different colors, optimal placement of the available inks is needed. Halftoning is a technique that deals with this challenge by generating a spatial distribution of the available inks that creates an illusion of the target color when viewed from a sufficiently large distance. Halftoning is a fundamental part of the color reproduction task in any full-color printing pipeline, and it is an effective technique to increase the potential of printing realistic and complex appearances. Although halftoning has been used in 2D printing for many decades, it still requires improvements in reproducing fine details and structures of images. Moreover, the emergence of new technologies in 3D printing introduces a higher degree of freedom and more parameters to the field of appearance reproduction. Therefore, there is a critical need for extensive studies to revisit existing halftoning algorithms and develop novel approaches to produce high quality prints that match the target appearance faithfully. This thesis aims at developing halftoning algorithms to improve appearance reproduction in 2D and 3D printing. 

    Contributions of this thesis in the 2D domain is a dynamic sharpness-enhancing halftoning approach, which adaptively varies the local sharpness of the halftone image based on different textures in the original image for realistic appearance printing. The results show improvements in halftone quality in terms of sharpness, preserving structural similarity, and decreasing color reproduction error. The main contribution of this thesis in 3D printing is extending a high quality 2D halftoning algorithm to the 3D domain. The proposed method is then integrated with a multi-layer printing approach, where ink is deposited at variable depths to improve the reproduction of tones and fine details. Results demonstrate that the proposed method accurately reproduces tones and details of the target appearance. Another contribution of this thesis is studying the effect of halftoning on the perceived appearance of 3D printed surfaces. According to the results, changing the dot placement based on the elevation variation of the underlying geometry can potentially control the perception of the 3D printed appearance. It implies that the choice of halftone may prove helpful in eliminating unwanted artifacts, enhancing the object’s geometric features, and producing a more accurate 3D appearance. The proposed methods in this thesis have been evaluated using different printing techniques.    

    List of papers
    1. 3D Halftoning based on Iterative Method Controlling Dot Placement
    Open this publication in new window or tab >>3D Halftoning based on Iterative Method Controlling Dot Placement
    2020 (English)Conference paper, Oral presentation with published abstract (Refereed)
    Abstract [en]

    Realistic appearance reproduction is of great importance in 3D printing’s applications. Halftoning as a necessary process in printing has a great impact on creating visually pleasant appearance. In this article, we study the aspects of adapting and applying Iterative Method Controlling Dot Placement (IMCDP) to halftone three-dimensional surfaces. Our main goal is to extend the 2D algorithm to a 3D halftoning approach with minor modifications. The results show high-quality reproduction for all gray tones. The 3D halftoning algorithm is not only free of undesirable artifacts, it also produces fully symmetric and wellformed halftone structures even in highlight and shadow regions.

    Keywords
    3D printing, 3D halftoning, Surface reproduction
    National Category
    Media Engineering
    Identifiers
    urn:nbn:se:liu:diva-171744 (URN)10.2352/ISSN.2169-4451.2020.36.69 (DOI)
    Conference
    Printing for Fabrication, Online 2020, October 19-21
    Available from: 2020-12-01 Created: 2020-12-01 Last updated: 2023-09-26Bibliographically approved
    2. 3D Surface Structures and 3D Halftoning
    Open this publication in new window or tab >>3D Surface Structures and 3D Halftoning
    2020 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    As 3D printing is becoming increasingly popular, the demand for high quality surface reproduction is also increasing. Like in 2D printing, halftoning plays an important role in the quality of the surface reproduction. Developing advanced 3D halftoning methods for 3D printing and adapting them to the structure of the surface is therefore essential for improving surface reproduction quality. In this paper, an extension of an iterative 2D halftoning method to 3D is used to apply different halftone structures on 3D surfaces. The results show that using different halftones based on the 3D geometrical structure of the surface and/or the viewing angle in combination with the structure of the texture being mapped on the surface can potentially improve the quality of the appearance of 3D surfaces.

    Place, publisher, year, edition, pages
    The Society for Imaging Science and Technology, 2020
    Keywords
    3D halftoning, Hybrid halftoning, 3D surface structures
    National Category
    Media Engineering
    Identifiers
    urn:nbn:se:liu:diva-170797 (URN)10.2352/ISSN.2169-4451.2020.36.75 (DOI)
    Conference
    Printing for Fabrication 2020
    Available from: 2020-10-22 Created: 2020-10-22 Last updated: 2024-01-02Bibliographically approved
    3. The Effect of Halftoning on the Appearance of 3D Printed Surfaces
    Open this publication in new window or tab >>The Effect of Halftoning on the Appearance of 3D Printed Surfaces
    2021 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    Managing the final appearance of 3D surfaces is an interesting and essential topic in 3D printing applications. Knowledge about the parameters which influence the 3D surface reproduction quality enables engineers to achieve the final appearance as accurately as designed. Many studies have been conducted to explore numerous parameters that affect the quality of 3D surface reproduction. This work contributes to verifying the role of halftoning in increasing the 3D surface visual quality and the control over the surface appearance of a 3D printed object. The results show that applying different halftones according to the geometrical characteristics of the 3D surface could emphasize or diminish the perceived 3D geometrical structures of a shape. The experimental results are in line with the simulated outputs reported in previous work. Our findings might introduce a new approach towards having more control over 3D appearance reproduction without changing the material or printer settings.

    Keywords
    3D printing, Halftoning, Surface appearance
    National Category
    Media Engineering
    Identifiers
    urn:nbn:se:liu:diva-180696 (URN)
    Conference
    47th Annual Conference of Iarigai
    Available from: 2021-10-29 Created: 2021-10-29 Last updated: 2023-09-26Bibliographically approved
    4. Structure-Aware Halftoning Using the Iterative Method Controlling the Dot Placement
    Open this publication in new window or tab >>Structure-Aware Halftoning Using the Iterative Method Controlling the Dot Placement
    2021 (English)In: Journal of Imaging Science and Technology, ISSN 1062-3701, E-ISSN 1943-3522, Vol. 65, no 6Article in journal (Refereed) Published
    Abstract [en]

    Many image reproduction devices, such as printers, are limited to only a few numbers of printing inks. Halftoning, which is the process to convert a continuous-tone image into a binary one, is, therefore, an essential part of printing. An iterative halftoning method, called Iterative Halftoning Method Controlling the Dot Placement (IMCDP), which has already been studied by research scholars, generally results in halftones of good quality. In this paper, we propose a structure-based alternative to this algorithm that improves the halftone image quality in terms of sharpness, structural similarity, and tone preservation. By employing appropriate symmetrical and non-symmetrical Gaussian filters inside the proposed halftoning method, it is possible to adaptively change the degree of sharpening in different parts of the continuous-tone image. This is done by identifying a dominant line in the neighborhood of each pixel in the original image, utilizing the Hough Transform, and aligning the dots along the dominant line. The objective and subjective quality assessments verify that the proposed structure-based method not only results in sharper halftones, giving more three-dimensional impression, but also improves the structural similarity and tone preservation. The adaptive nature of the proposed halftoning method makes it an appropriate algorithm to be further developed to a 3D halftoning method, which could be adapted to different parts of a 3D object by exploiting both the structure of the images being mapped and the 3D geometrical structure of the underlying printed surface.

    Place, publisher, year, edition, pages
    I S & T-SOC IMAGING SCIENCE TECHNOLOGY, 2021
    Keywords
    Halftoning, Structure-Aware Halftoning, Hough Transform, Image Quality Evaluation
    National Category
    Media Engineering
    Identifiers
    urn:nbn:se:liu:diva-181613 (URN)10.2352/j.imagingsci.technol.2021.65.6.060404 (DOI)000734009600011 ()
    Note

    Funding: ApPEARS (Appearance Printing European Advanced Research School); European Unions Horizon 2020 programme under the Marie Skodowska-Curie [814158]

    Available from: 2021-12-04 Created: 2021-12-04 Last updated: 2023-09-26Bibliographically approved
    5. Structure-Aware Color Halftoning with Adaptive Sharpness Control
    Open this publication in new window or tab >>Structure-Aware Color Halftoning with Adaptive Sharpness Control
    2022 (English)In: Journal of Imaging Science and Technology, ISSN 1062-3701, E-ISSN 1943-3522, Vol. 66, no 6, article id 060404Article in journal (Refereed) Published
    Abstract [en]

    Structure-aware halftoning algorithms aim at improving their non-structure-aware version by preserving high-frequency details, structures, and tones and by employing additional information from the input image content. The recently proposed achromatic structure-aware Iterative Method Controlling the Dot Placement (IMCDP) halftoning algorithm uses the angle of the dominant line in each pixels neighborhood as supplementary information to align halftone structures with the dominant orientation in each region and results in sharper halftones, gives a more three-dimensional impression, and improves the structural similarity and tone preservation. However, this method is developed only for monochrome halftoning, the degree of sharpness enhancement is constant for the entire image, and the algorithm is prohibitively expensive for large images. In this paper, we present a faster and more flexible approach for representing the image structure using a Gabor-based orientation extraction technique which improves the computational performance of the structure-aware IMCDP by an order of magnitude while improving the visual qualities. In addition, we extended the method to color halftoning and studied the impact of orientation information in different color channels on improving sharpness enhancement, preserving structural similarity, and decreasing color reproduction error. Furthermore, we propose a dynamic sharpness enhancement approach, which adaptively varies the local sharpness of the halftone image based on different textures across the image. Our contributions in the present work enable the algorithm to adaptively work on large images with multiple regions and different textures. (C) 2022 Society for Imaging Science and Technology.

    Place, publisher, year, edition, pages
    I S & T-SOC IMAGING SCIENCE TECHNOLOGY, 2022
    National Category
    Media Engineering
    Identifiers
    urn:nbn:se:liu:diva-192705 (URN)10.2352/J.ImagingSci.Technol.2022.66.6.060404 (DOI)000939908300011 ()
    Note

    Funding Agencies|ApPEARS (Appearance Printing European Advanced Research School); European Unions Horizon 2020 programme under the Marie Sklodowska-Curie grant [814158]

    Available from: 2023-03-31 Created: 2023-03-31 Last updated: 2023-09-26
    6. Effect of halftones on printing iridescent colors
    Open this publication in new window or tab >>Effect of halftones on printing iridescent colors
    2023 (English)In: IS&T Electronic Imaging: Color Imaging XXVIII: Displaying, Processng, Hardcopy, and Applications, The Society for Imaging Science and Technology, 2023, Vol. 35, p. 1-6Conference paper, Published paper (Refereed)
    Abstract [en]

    The iridescent effect produced by structural color is difficult (if not impossible) to capture and print using traditional CMYK pigments. The so called RGB reflective pigments, nonetheless, generate angle-dependent colors by light interference. A layered surface structure generated by the pigments’ particles on a substrate reflects light waves of different wavelengths at different viewing angles according to the optical principle known as the Bragg Law. In this work, we have studied the influence of different halftone structures on printed images, produced with RGB reflective inks via screen printing. The main goal was to enhance the iridescence of a printed reproduction by studying the performance of different halftone algorithms on a screen printing process. We investigated the influence of different halftone structures in creating different spatial combinations of inks on a print to reproduce the image of an iridescent feathered headdress. We applied first-order, second-order, and structure-aware FM halftones to compare how they influence the reproduction of the material appearance of the object represented in the original image. The results show that the structure-ware halftones improve the representation of the image structures and details. Therefore, it could better convey the 3D surface features that produce iridescence in real feathers.

    Place, publisher, year, edition, pages
    The Society for Imaging Science and Technology, 2023
    National Category
    Media Engineering
    Identifiers
    urn:nbn:se:liu:diva-197992 (URN)
    Conference
    IS&T Electronic Imaging
    Available from: 2023-09-20 Created: 2023-09-20 Last updated: 2023-09-26
    Download full text (pdf)
    fulltext
    Download (png)
    presentationsbild
  • 20.
    Qu, Jianxin
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    Kunnappallil, Nikil Johny
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    2D Orientation Estimation Using Machine Learning With Multiple 5G Base Stations2022Independent thesis Advanced level (degree of Master (Two Years)), 28 HE creditsStudent thesis
    Abstract [en]

    Localization of mobile devices has implications on a multitude of use cases such as estimating the location of the user originating an emergency call, localization of devices to enable autonomous operation required by industrial Internet of Things (IoT) use cases, etc. In futuristic use cases such as Augmented Reality (AR), Virtual Reality (VR), Extended Reality (XR), autonomous navigation of Unmanned Aerial Vehicles (UAVs), we will require the capability of estimating orientation in addition to position of such devices for efficient and effective provisioning of these services to the end-users.

    One way to handle the problem of finding the orientation of devices is to rely on the measurements from different sensors like the magnetometer, accelerometer and gyroscope but the limitation of this method is the dependency on these sensors, and thus cannot be used for some devices which does not have these sensors. Hence these limitations can be overcome by using data-driven approaches like Machine Learning (ML) algorithms on received signal features, where a training dataset with orientation measurements are used to train the ML model that can transform the received signal measurements to orientation estimates.

    The data for the work is generated by using simulator that can simulate the environment with multiple base stations and receivers. The measurements or features that are generated from the simulator are the Received Signal Received Power (RSRP), Time of Arrival (ToA), Line of Sight (LoS) condition, etc. In-order to find the relationship between the received signal features and orientation, two nonlinear ML algorithms namely K Nearest Neighbors (KNN) and Random Forest (RF) are used. The received measurements were investigated and RSRP was identified as the feature for the ML models.

    The ML algorithms are able to estimate the orientation of the User Equipment (UE) by using KNN and RF, where different features likes RSRP and the information about LoS and Non Line of Sight (NLoS). These features were used alone and also combined to evaluate the performance. The results also shows how interference of radio signals affects the performance of the model. Adding to that, different combination of received signal features were also used to compare the performance of the model. Further tests were also done on the trained model to identify how well it can estimate orientation when a new UE with new position is introduced.

    Download full text (pdf)
    fulltext
  • 21.
    Forsgren, Mikael
    et al.
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
    Bengtsson, Ann
    Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.
    Dahlqvist Leinhard, Olof
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.
    Sören, Birgitta
    Linköping University, Department of Medical and Health Sciences, Physiotherapy. Linköping University, Faculty of Health Sciences.
    Brandejsky, Vaclav
    Depts Clinical Research and Radiology, University Bern, Bern, Switzerland.
    Lund, Eva
    Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.
    Lundberg, Peter
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.
    31P MRS as a Potential Biomarker for Fibromyalgia2012In: Proceedings of the 20th Annaal Meeting & Exhibition, 5-11 May, Melbourne, Australia, 2012, p. 1493-1493Conference paper (Refereed)
    Abstract [en]

    Major clinical symptoms in fibromyalgia (FM) are muscle pain, stiffness and fatigue. Studies have shown reduced voluntary strength and exercise capacity, lower endurance and more muscular pain even at low workload. An impaired muscle energy metabolism has therefore been proposed as a result of the disease. An earlier study using magnetic resonance spectroscopy (MRS) showed that at maximal dynamic and static contractions the concentration of inorganic phosphate was lower in FM [1]. A decrease in ATP, ADP and PCr and an increase in AMP and creatine was found in FM biopsies [2]. The purpose of this study was to non-invasively analyze the quantitative content of  phosphagens in the resting muscle in FM in comparison to healthy controls using 31P MRS of the quadriceps muscle.

  • 22.
    Li, Wei
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences.
    Yuan, Ximing
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine.
    Ivanova, S.
    Laboratory of Biomedical Science, North Shore-LIE Research Institute, Manhasset, NY 11030, United States.
    Tracey, K.J.
    Laboratory of Biomedical Science, North Shore-LIE Research Institute, Manhasset, NY 11030, United States.
    Eaton, John Wallace
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology . Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Brunk, Ulf
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Pharmacology .
    3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin2003In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 371, no 2, p. 429-436Article in journal (Refereed)
    Abstract [en]

    Cytotoxic polyamine-derived amino aldehydes, formed during cerebral ischaemia, damage adjacent tissue (the so-called 'penumbra') not subject to the initial ischaemic insult. One such product is 3-aminopropanal (3-AP), a potent cytotoxin that accumulates in ischaemic brain, although the precise mechanisms responsible for its formation are still unclear. More relevant to the present investigations, the mechanisms by which such a small aldehydic compound might be cytotoxic are also not known, but we hypothesized that 3-AP, having the structure of a weak lysosomotropic base, might concentrate within lysosomes, making these organelles a probable focus of initial toxicity. Indeed, 3-AP leads to lysosomal rupture of D384 glioma cells, a process which clearly precedes caspase activation and apoptotic cell death. Immunohistochemistry reveals that 3-AP concentrates in the lysosomal compartment and prevention of this accumulation by the lysosomotropic base ammonia, NH3, protects against 3-AP cytotoxicity by increasing lysosomal pH. A thiol compound, N-(2-mercaptopropionyl)glycine, reacts with and neutralizes 3-AP and significantly inhibits cytoxocity. Both amino and aldehyde functions of 3-AP are necessary for toxicity: the amino group confers lysosomotropism and the aldehyde is important for additional, presently unknown, reactions. We conclude that 3-AP exerts its toxic effects by accumulating intralysosomally, causing rupture of these organelles and releasing lysosomal enzymes which initiate caspase activation and apoptosis (or necrosis if the lysosomal rupture is extensive). These results may have implications for the development of new therapeutics designed to lessen secondary damage arising from focal cerebral ischaemia.

  • 23.
    Eriksson, Henrik
    et al.
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
    Magnusson, Henrik
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
    Fritzson, Peter
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
    Pop, Adrian Dan Iosif
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
    3D Animation and Programmable 2D Graphics for Visualization of Simulations in OpenModelica2008In: Proceedings from the 49th Scandinavian Conference on Simulation and Modeling, 2008, www.scansims.org: Scandinavian Simulation Society , 2008, p. 10-Conference paper (Refereed)
    Abstract [en]

    This paper describes recent work on visualization of simulation results from simulating Modelica models in Open-Modelica. A new 3D graphics package with interactive animation and a new flexible programmable 2D graphicshave been added to OpenModelica. The 2D graphics package provides very flexible usage, either directly from asimulation, from the electronic book client OMNotebook, or programmable graphics, called directly from aModelica model.

  • 24.
    Jarnemyr, Pontus
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems.
    Markus, Gustafsson
    Linköping University, Department of Computer and Information Science, Software and Systems.
    3D Camera Selection for Obstacle Detection in a Warehouse Environment2020Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    The increasing demand for online commerce has led to an increasing demand of autonomous vehicles in the logistics sector. The work in this thesis aims to improve the obstacle detection of autonomous forklifts by using 3D sensor technology. Three different products were compared based on a number of criteria. These criteria were provided by Toyota Material Handling, a manufacturer of autonomous forklifts. One of the products was chosen for developing a prototype. The prototype was used to determine if 3D camera technology could provide sufficient obstacle detection in a warehouse environment. The determination was based on the prototype's performance in a series of tests. The tests ranged from human to pallet detection, and were aimed to fulfill all criteria. The advantages and disadvantages of the chosen camera is presented. The conclusion is that the chosen 3D camera cannot provide sufficient obstacle detection due to certain environmental factors.

    Download full text (pdf)
    fulltext
  • 25.
    Rasmus, Siljedahl
    Linköping University, Department of Computer and Information Science.
    3D Conversion from CAD models to polygon models2016Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    This thesis describes the design and implementation of an application that converts CAD models into polygon models. When going from CAD models to 3D polygon models a conversion of the file type has to be performed. XperDI uses these polygon models in their tool, called sales configurator, to create a photo realistic environment to be able to have a look at the end product before it is manufactured. Existing tools are difficult to use and is missing features that is important for the Sales Configurator. The purpose of this thesis is to create a proof of concept application that converts CAD models into 3D polygon models. This new lightweight application is a simpler alternative to convert CAD models into polygon models and offers features needed for the intended use of these models, that the alternative products do not offer.

    Download full text (pdf)
    fulltext
  • 26.
    Ong, Jeb A.
    et al.
    Maisonneuve Rosemt Hospital, Canada; University of Montreal, Canada.
    Auvinet, Edouard
    University of Montreal, Canada.
    Forget, Karolyn J.
    Maisonneuve Rosemt Hospital, Canada.
    Lagali, Neil
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
    Fagerholm, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
    Griffith, May
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Maisonneuve Rosemt Hospital, Canada.
    Meunier, Jean
    University of Montreal, Canada; University of Montreal, Canada.
    Brunette, Isabelle
    Maisonneuve Rosemt Hospital, Canada; University of Montreal, Canada.
    3D Corneal Shape After Implantation of a Biosynthetic Corneal Stromal Substitute2016In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, no 6, p. 2355-2365Article in journal (Refereed)
    Abstract [en]

    PURPOSE. The current and projected shortage of transplantable human donor corneas has prompted the development of long-term alternatives to human donor tissue for corneal replacement. The biosynthetic stromal substitutes (BSS) characterized herein represent a potentially safe alternative to donor organ transplantation for anterior corneal stromal diseases. The goal of this phase 1 safety study was to characterize the three-dimensional (3D) corneal shape of the first 10 human patients implanted with a BSS and assess its stability over time. METHODS. Ten patients underwent anterior lamellar keratoplasty using a biosynthetic corneal stromal implant for either advanced keratoconus or central corneal scarring. Surgeries were performed at Linkoping University Hospital, between October and November 2007. Serial corneal topographies were performed on all eyes up to a 4-year follow-up when possible. Three-dimensional shape average maps were constructed for the 10 BSS corneas and for 10 healthy controls. Average 3D shape corneal elevation maps, difference maps, and statistics maps were generated. RESULTS. The biosynthetic stromal substitutes implants remained stably integrated into the host corneas over the 4-year follow-up period, without signs of wound dehiscence or implant extrusion. The biosynthetic stromal substitutes corneas showed steeper surface curvatures and were more irregular than the healthy controls. CONCLUSIONS. Corneal astigmatism and surface steepness were observed 4 years after BSS implantation, while the implants remained stably integrated in the host corneas. Future studies will indicate if biomaterials technology will allow for the optimization of postoperative surface irregularity after anterior stromal replacement, a new window of opportunity that is not available with traditional corneal transplantation techniques.

    Download full text (pdf)
    fulltext
  • 27.
    Kim, Jun Woo
    et al.
    Korea Univ, South Korea.
    Kim, Nam Keun
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Incheon Natl Univ, South Korea.
    Stenfelt, Stefan
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Sensory Organs and Communication. Linköping University, Faculty of Medicine and Health Sciences.
    Shim, Joon Hyung
    Korea Univ, South Korea.
    3D EVALUATION OF THERMAL STRESSES ON CERAMIC-METAL COMPOSITES USED AT HIGH TEMPERATURE OPERATION2017In: 5TH IIR INTERNATIONAL CONFERENCE ON THERMOPHYSICAL PROPERTIES AND TRANSFER PROCESSES OF REFRIGERANTS (TPTPR), INT INST REFRIGERATION , 2017, p. 771-775Conference paper (Refereed)
    Abstract [en]

    Ceramic-metal composites (CMC) have been used for various high temperature applications including combustion engines, steam and gas turbines, industrial heaters and ceramic fuel cells. Reliable incorporation of the CMC at elevated temperatures, however, is very difficult in practice for the following reasons. First, meting and sublimation points of those solids are different causing undesired diffusion and mixing of elements across the material boundaries degrading functions of the materials. Secondly, maintaining temperature and pressure regimes for desired phases of the component materials is challenging during operation in many of practical cases. Lastly, thermal expansion rates of those two materials are significantly different frequently causing mechanical stresses and fractures. There have been numerous efforts to evaluate and design the CMC materials to minimize the thermo-mechanical stresses. Among various techniques, the focused ion beam-scanning electron microscope (FIB-SEM) tomography has been proved as a state-of-art technique to obtain 3D compositional and structural information of the CMC materials. In this study, we have evaluated thermal stresses applied on nickel-zirconia CMCs by using the FIB-SEM 3D tomography and finite element analysis.

  • 28.
    Chen, Zhenzhong
    et al.
    School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, South Korea.
    Han, Seokgyu
    School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, South Korea.
    Sanny, Arleen
    Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore.
    Chan, Dorothy Leung-Kwan
    Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore.
    van Noort, Danny
    Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering. Centro de Investigación en Bioingeniería, Universidad de Ingenieria y Tecnologia - UTEC, Lima, Peru.
    Lim, Wanyoung
    Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, South Korea.
    Tan, Andy Hee-Meng
    Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore.
    Park, Sungsu
    School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, South Korea; Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, South Korea; Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon, South Korea.
    3D hanging spheroid plate for high-throughput CART cell cytotoxicity assay2022In: Journal of Nanobiotechnology, E-ISSN 1477-3155, Vol. 20, no 1, article id 30Article in journal (Refereed)
    Abstract [en]

    Background: Most high-throughput screening (HIS) systems studying the cytotoxic effect of chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture that does not recapitulate the tumor micro-environment (TME). Tumor spheroids, however, can recapitulate the TME and have been used for cytotoxicity assays of CART cells. But a major obstacle to the use of tumor spheroids for cytotoxicity assays is the difficulty in separating unbound CART and dead tumor cells from spheroids. Here, we present a three-dimensional hanging spheroid plate (3DHSP), which facilitates the formation of spheroids and the separation of unbound and dead cells from spheroids during cytotoxicity assays.

    Results: The 3DHSP is a 24-well plate, with each well composed of a hanging dripper, spheroid wells, and waste wells. In the dripper, a tumor spheroid was formed and mixed with CART cells. In the 3DHSP, droplets containing the spheroids were deposited into the spheroid separation well, where unbound and dead T and tumor cells were separated from the spheroid through a gap into the waste well by tilting the 3DHSP by more than 20 degrees. Human epidermal growth factor receptor 2 (HER2)-positive tumor cells (BT474 and SKOV3) formed spheroids of approximately 300-350 pm in diameter after 2 days in the 3DHSP. The cytotoxic effects ofT cells engineered to express CAR recognizing HER2 (HER2-CAR T cells) on these spheroids were directly measured by optical imaging, without the use of live/dead fluorescent staining of the cells. Our results suggest that the 3DHSP could be incorporated into a HTS system to screen for CARs that enable T cells to kill spheroids formed from a specific tumor type with high efficacy or for spheroids consisting of tumor types that can be killed efficiently by T cells bearing a specific CAR.

    Conclusions: The results suggest that the 3DHSP could be incorporated into a HTS system for the cytotoxic effects of CART cells on tumor spheroids.

    Download full text (pdf)
    fulltext
  • 29.
    Fowler, Scott
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Baravdish, Gabriel
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Baravdish, George
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    3D Imaging of Sparse Wireless Signal Reconstructions via Machine Learning2020In: ICC 2020 - 2020 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC), IEEE , 2020Conference paper (Refereed)
    Abstract [en]

    Wireless devices have been used to investigate the environment and to understand our physical world. In this work, we undertake the challenging problem of identifying location of obstacles and objects by WiFi signals. Gathering wireless sensory data to form an image is difficult since wireless signals are susceptible to multipath. Moreover, reconstructing an image of unknown objects based on the measurements of sparse signals is an ill-posed problem. To tackle these problems, we first present a linear model using received signal strength indicator (RSSI) measurements. We define the sparse beamforming problem as an l(0)-norm optimization problem, then use the iterative reweighted l(1) heuristic algorithm to obtain an optimal solution as a multipath. Finally, the multipath fading is removed by using Machine Learning. More specifically, we use Support Vector Regression (SVR) to identify a clear image of the unknown object. Our results show that the proposed method can reconstruct signals as a 3D image with a satisfactory visual appearance, i.e. the generated data mesh is well defined and smooth compared to previous work.

  • 30.
    Konradsson, Albin
    et al.
    Linköping University, Department of Electrical Engineering, Computer Vision.
    Bohman, Gustav
    Linköping University, Department of Electrical Engineering, Computer Vision.
    3D Instance Segmentation of Cluttered Scenes: A Comparative Study of 3D Data Representations2021Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis provides a comparison between instance segmentation methods using point clouds and depth images. Specifically, their performance on cluttered scenes of irregular objects in an industrial environment is investigated.

    Recent work by Wang et al. [1] has suggested potential benefits of a point cloud representation when performing deep learning on data from 3D cameras. However, little work has been done to enable quantifiable comparisons between methods based on different representations, particularly on industrial data.

    Generating synthetic data provides accurate grayscale, depth map, and point cloud representations for a large number of scenes and can thus be used to compare methods regardless of datatype. The datasets in this work are created using a tool provided by SICK. They simulate postal packages on a conveyor belt scanned by a LiDAR, closely resembling a common industry application. Two datasets are generated. One dataset has low complexity, containing only boxes.The other has higher complexity, containing a combination of boxes and multiple types of irregularly shaped parcels.

    State-of-the-art instance segmentation methods are selected based on their performance on existing benchmarks. We chose PointGroup by Jiang et al. [2], which uses point clouds, and Mask R-CNN by He et al. [3], which uses images.

    The results support that there may be benefits of using a point cloud representation over depth images. PointGroup performs better in terms of the chosen metric on both datasets. On low complexity scenes, the inference times are similar between the two methods tested. However, on higher complexity scenes, MaskR-CNN is significantly faster.

    Download full text (pdf)
    fulltext
  • 31.
    Johansson, Erik
    Linköping University, Department of Electrical Engineering.
    3D Reconstruction of Human Faces from Reflectance Fields2004Independent thesis Basic level (professional degree)Student thesis
    Abstract [en]

    Human viewers are extremely sensitive to the appearanceof peoples faces, which makes the rendering of realistic human faces a challenging problem. Techniques for doing this have continuously been invented and evolved since more than thirty years.

    This thesis makes use of recent methods within the area of image based rendering, namely the acquisition of reflectance fields from human faces. The reflectance fields are used to synthesize and realistically render models of human faces.

    A shape from shading technique, assuming that human skin adheres to the Phong model, has been used to estimate surface normals. Belief propagation in graphs has then been used to enforce integrability before reconstructing the surfaces. Finally, the additivity of light has been used to realistically render the models.

    The resulting models closely resemble the subjects from which they were created, and can realistically be rendered from novel directions in any illumination environment.

    Download full text (pdf)
    FULLTEXT01
  • 32.
    Arvidsson, Peter
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    3D Visualization Package for OpenModelica2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    A 3D representation of a physical phenomena is often a good way to present it. It’s often easier to see an event in an animation rather than just read data tables. The goal of this thesis is to create an application that visualizes a physical simulation in Modelica. This thesis explains how the OMVisualize application was developed. To create the OMVisualize the OpenSceneGraph library was used. The OpenSceneGraph is a 3D package written in C++ that is used in many different applications from game to scientific applications.

    Download full text (pdf)
    fulltext
  • 33.
    Chau, Chieu Vinh
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    3D-modeling of Norrköping2007Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The interest for a detailed and high solution city model has been large within the project” Optical signature analysis” at the department for Sensor Technology in FOI, Linköping. Thus, a textured 3D-model over Norrköping is needed, which later can be imported into simulation software to study optical signature in urban environment.

    The aim with this thesis work is to be able to use the result as a multi-used 3D-model within applications of the Swedish defence force for future usage. It is important to have a realistic representation of the environment so that the exercises can be planned and analyzed at the current position.

    For the final result to be as good as possible, the thesis work has been concentrated and limited into a smaller area, i.e. the quarter of Svärdet at Nya torget. Thereafter the thesis work has been divided into different stages: photographing, laser measurement, photomontage, modeling and texturing.

    One of the most important and extensive stages is to make the high solution and detailed texture pictures with photomontage. These pictures are first created with photographing and then be performed into panorama pictures. Further, the thesis work has been performed with suitable software, such as 3ds Max and Photoshop CS.

    The finished 3D-model will be supplied as a 3ds-file and max-file, where the textured pictures from the model have been moved into a folder to facilitate future works, for example in classification of texture-pictures.

    Download full text (pdf)
    fulltext
  • 34.
    Bergroth, Jonathan
    et al.
    Linköping University, Department of Computer and Information Science.
    Biel, Tobias
    Linköping University, Department of Computer and Information Science.
    Hedblom, Anna
    Linköping University, Department of Computer and Information Science.
    Johansson, Elias
    Linköping University, Department of Computer and Information Science.
    Larsson, Theodor
    Linköping University, Department of Computer and Information Science.
    Nordström, Erik
    Linköping University, Department of Computer and Information Science.
    Rasmussen, Joakim
    Linköping University, Department of Computer and Information Science.
    Wegeström, Anton
    Linköping University, Department of Computer and Information Science.
    Widéen, Hannes
    Linköping University, Department of Computer and Information Science.
    3D-visualisering av autonoma system2023Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Drönare är ett växande fenomen i dagens samhälle och deras användningsområdenhar snabbt ökat de senaste åren. För att underlätta utvecklingen av drönarteknologi kansimuleringar tillämpas då de möjliggör testning i en kontrollerad och riskfri miljö. I dettaprojekt visualiseras simuleringar av drönare i ett försök att skapa värde för denna utveckling. Visualiseringen skedde med hjälp av Unreal Engine 5. Under projektets gång studerades arbetsmetoderna som nyttjades och hur en systemanatomi kan bidra till utvecklingen iett småskaligt mjukvaruprojekt. Största värdet som producerades för kunden var kommunikationsmodulen. Kommunikationen uppnåddes med hjälp av två JSON-filer som visualiseringen respektive simuleringen skrev till för att kommunicera med varandra. Värdeti denna modul ligger i att kunden sökte en modulär lösning för att kommunicera mellanen 3D-visualisering och en simulering. En erfarenhet som uppmärksammades angåendearbetsmetoderna är vikten av en fungerande gruppdynamik. Bidragande faktorer till detvar agila arbetsmetoder, goda kommunikationsvägar och en väl planerad användning avGit. Systemanatomier upplevdes ge begränsat värde till projektet.

    Download full text (pdf)
    3d visualisering av autonoma system
  • 35.
    Andersson, Tim
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Lind, Kristoffer
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    3D-visualization of residential buildings in Manstorp2007Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In real estate ads in both newspapers and on the Internet, there are more and more computer modeled houses for sale. We believe that this is one of the biggest markets for visualization today. When time and technology are ready, we expect that visualization will be used a lot more to create projects where people can “trust” in what is being visualized. For our final thesis we wanted to work with

    Visualization, our concentration within the Construction Engineering program at Linköping University. We managed to do this with the construction company Peab in Linköping, who wanted to make their marketing of their project Manstorp in Linghem more efficient. The pictures that the hired architect firm used to visualize the property with were not sufficient enough, according to Peab, in giving the true picture of the area. The goal for our thesis was to create more realistic and living images, and thereby help Peab sell all of the real estates before completing the constructions.

    We were continuously given material from Peab and the architect firm White in order to visualize a realistic set of pictures for potential clients. One of computer visualizations biggest advantages is that it is easy to modify the models according to changes in the material given. Compared to classic design methods such as hand-drawn sketches, physical models and computer manipulated pictures it was easy for us to change features such as color, displacement and size. We wanted to show how the cooperation between people who visualizes, construction companies and architects could work, where problems could evolve and which solutions and methods are to be preferred.

    The goal was to create a model of the exterior and interior of the individual buildings in their final environment and display this with pictures on Peab’s and the real estate agent’s website. We achieved this goal and the result can be seen at:

    http://www.peab.se/Bostader_lokaler/Bostader/ostergotland/Linkoping/Manstorp

    Download full text (pdf)
    fulltext
  • 36. Stuart, G
    et al.
    Åvall-Lundqvist, Elisabeth
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    du Bois, A
    Bookman, M
    Bowtell, D
    Brady, M
    Casado, A
    Cervantes, A
    Eisenhauer, E
    Friedlaender, M
    Fujuwara, K
    Grenman, S
    Guastalla, JP
    Harper, P
    Högberg, Thomas
    NSGO (Scandinavia).
    Kaye, S
    Kitchener, H
    Kristensen, G
    Mannel, R
    Meier, W
    Miller, B
    Oza, A
    Ozols, R
    Parmar, M
    Pfisterer, J
    Poveda, A
    Provencher, D
    Pujade-Lauraine, E
    Quinn, M
    Randall, M
    Rochon, J
    Rustin, G
    Sagae, S
    Stehman, F
    Trimble, E
    Thigpen, T
    Vasey, P
    Vergote, I
    Verheijen, R
    Vermorken, J
    Wagner, U
    3rd international ovarian cancer consensus conference: outstanding issues for future consideration2005In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 16, no supplement 8, p. viii36-viii38Article in journal (Refereed)
  • 37.
    Cahill, N
    et al.
    Uppsala University, Sweden.
    Bergh, Ann-Charlotte
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Kanduri, M
    Uppsala University, Sweden.
    Göransson-Kultima, H
    Uppsala University, Sweden.
    Mansouri, L
    Uppsala University, Sweden.
    Isaksson, A
    Sahlgrenska University Hospital, Sweden.
    Ryan, F
    Institute of Technology, Dublin, Ireland.
    Smedby, K E
    Karolinska Institutet, Stockholm, Sweden.
    Juliusson, G
    Institute of Technology, Dublin, Ireland.
    Sundström, C
    Uppsala University, Sweden.
    Rosén, Anders
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Rosenquist, R
    Uppsala University, Sweden.
    450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments2013In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 27, no 1, p. 150-158Article in journal (Refereed)
    Abstract [en]

    In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression patterns; however, knowledge is limited regarding the extent to which methylation changes with time and exposure to specific microenvironments. Using high-resolution 450K-arrays, we provide the most comprehensive DNA methylation study of CLL to date, analysing paired diagnostic/follow-up samples from IGHV-mutated/untreated and IGHV-unmutated/treated patients (n=36) and patient-matched peripheral blood and lymph node samples (n=20). On an unprecedented scale, we revealed 2239 differentially methylated CpG sites between IGHV-mutated and unmutated patients, with the majority of sites positioned outside annotated CpG islands. Intriguingly, CLL prognostic genes (e.g. CLLU1, LPL, ZAP70, NOTCH1), epigenetic regulator (e.g. HDAC9, HDAC4, DNMT3B), B-cell signaling (e.g. IBTK) and numerous TGF-ß and NF-κB/TNF pathway genes were alternatively methylated between subgroups. Contrary, DNA methylation over time was deemed rather stable with few recurrent changes noted within subgroups. Although a larger number of non-recurrent changes were identified among IGHV-unmutated relative to mutated cases over time, these equated to a low global change. Similarly, few changes were identified between compartment cases. Altogether, we reveal CLL subgroups to display unique methylation profiles and unveil methylation as relatively stable over time and similar within different CLL compartments, implying aberrant methylation as an early leukemogenic event.Leukemia accepted article preview online, 27 August 2012; doi:10.1038/leu.2012.245.

  • 38.
    Evaldsson, Chamilly
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
    Rydén, Ingvar
    Division of Clinical Chemistry, Kalmar County Hospital, Kalmar, Sweden.
    Rosén, Anders
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Uppugunduri, Srinivas
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
    4-Thiouridine induces dose-dependent reduction of oedema, leucocyte influx and tumour necrosis factor in lung inflammation2009In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 155, no 2, p. 330-338Article in journal (Refereed)
    Abstract [en]

    Recent reports demonstrate a role for nucleotides as inflammatory modulators. Uridine, for example, reduces oedema formation and leucocyte infiltration in a Sephadex-induced lung inflammation model. Tumour necrosis factor (TNF) concentration was also reduced. Previous in vivo observations indicated that 4-thiouridine might have similar effects on leucocyte infiltration and TNF release. The aim of this study was thus to investigate the effects of 4-thiouridine in greater detail. We used a Sephadex-induced acute lung inflammation model in Sprague-Dawley rats. The dextran beads were instilled intratracheally into the lungs, which were excised and examined after 24 h. Sephadex alone led to massive oedema formation and infiltration of macrophages, neutrophils and eosinophils. Microgranulomas with giant cell formations were clearly visible around the partially degraded beads. A significant increase in bronchoalveolar lavage fluid (BALF) content of TNF and leukotrienes was also seen. 4-Thiouridine co-administration affected all variables investigated in this model, i.e. oedema, microscopic and macroscopic appearance of lung tissue, total leucocyte and differential leucocyte counts in BALF, TNF and leukotrienes C-4 (LTC4), LTD4 and LTE4 in BALF, indicating a reproducible anti-inflammatory effect. In conclusion, we have demonstrated that 4-thiouridine has anti-inflammatory effects similar to those of uridine. To our knowledge, this is the first demonstration of pharmacological 4-thiouridine effects in vivo. The results suggest nucleoside/nucleotide involvement in inflammatory processes, warranting further studies on nucleoside analogues as attractive new alternatives in the treatment of inflammatory diseases.

    Download full text (pdf)
    FULLTEXT02
  • 39.
    Baron, Ralf
    et al.
    University Klinikum Schleswig Holstein.
    Mayoral, Victor
    Hospital Llobregat.
    Leijon, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Neurology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Binder, Andreas
    University Klinikum Schleswig Holstein.
    Steigerwald, Ilona
    Grunenthal GmbH.
    Serpell, Michael
    University of Glasgow.
    5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study2009In: CURRENT MEDICAL RESEARCH AND OPINION, ISSN 0300-7995, Vol. 25, no 7, p. 1663-1676Article in journal (Refereed)
    Abstract [en]

    Objective: To compare efficacy and safety of 5% lidocaine medicated plaster with pregabalin in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneuropathy (DPN). Study design and methods: This was a two-stage adaptive, randomized, open-label, multicentre, non-inferiority study. Data are reported from the initial 4-week comparative phase, in which adults with PHN or painful DPN received either topical 5% lidocaine medicated plaster applied to the most painful skin area or twice-daily pregabalin capsules titrated to effect according to the Summary of Product Characteristics. The primary endpoint was response rate at 4 weeks, defined as reduction averaged over the last three days from baseline of greater than= 2 points or an absolute value of less than= 4 points on the 11-point Numerical Rating Scale (NRS-3). Secondary endpoints included 30% and 50% reductions in NRS-3 scores; change in allodynia severity rating; quality of life (QoL) parameters EQ-5D, CGIC, and PGIC; patient satisfaction with treatment; and evaluation of safety (laboratory parameters, vital signs, physical examinations, adverse events [AEs], drug-related AEs [DRAEs], and withdrawal due to AEs). Results: Ninety-six patients with PHN and 204 with painful DPN were analysed (full analysis set, FAS). Overall, 66.4% of patients treated with the 5% lidocaine medicated plaster and 61.5% receiving pregabalin were considered responders (cor-responding numbers for the per protocol set, PPS: 65.3% vs. 62.0%). In PHN more patients responded to 5% lidocaine medicated plaster treatment than to pregabalin (PPS: 62.2% vs. 46.5%), while response was comparable for patients with painful DPN (PPS: 66.7% vs 69.1%). 30% and 50% reductions in NRS-3 scores were greater with 5% lidocaine medicated plaster than with pregabalin. Both treatments reduced allodynia severity. 5% lidocaine medicated plaster showed greater improvements in QoL based on EQ-5D in both PHN and DPN. PGIC and CGIC scores indicated greater improvement for 5% lidocaine medicated plaster treated patients with PHN. Improvements were comparable between treatments in painful DPN. Fewer patients administering 5% lidocaine medicated plaster experienced AEs (safety set, SAF: 18.7% vs. 46.4%), DRAEs (5.8% vs. 41.2%) and related discontinuations compared to patients taking pregabalin. Conclusion: 5% lidocaine medicated plaster showed better efficacy compared with pregabalin in patients with PHN. Within DPN, efficacy was comparable for both treatments. 5% lidocaine medicated plaster showed a favourable efficacy/safety profile with greater improvements in patient satisfaction and QoL compared with pregabalin for both indications, supporting its first line position in the treatment of localized neuropathic pain.

  • 40.
    Ponticorvo, A.
    et al.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Rowland, R.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Baldado, M.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Kennedy, G. T.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Saager, Rolf B.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Burmeister, D. M.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Christy, R. J.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Bernal, N.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    Durkin, A. J.
    Beckman Laser Institute, UC Irvine, Irvine, CA; US Army Institute of Surgical Research, San Antonio, TX; University of California Irvine, Irvine, CA, USA.
    529 Evaluating Clinical Observation, Spatial Frequency Domain Imaging (SFDI) and Laser Speckle Imaging (LSI) for the Assessment of Burns2018In: Journal of Burn Care & Research, ISSN 1559-047X, E-ISSN 1559-0488, Vol. 39, no Suppl_1, p. S238-S239Article in journal (Refereed)
    Abstract [en]

    Introduction

    The current standard for diagnosis of burn severity and subsequent wound healing is through clinical examination, which is highly subjective. Several new technologies focus on burn care in an attempt to help clinicians quantify burn severity earlier and more accurately. Laser Speckle Imaging (LSI) is a technique that quantifies perfusion to assess burn wounds while Spatial Frequency Domain Imaging (SFDI) can quantify the structural damage caused by burns. Here we test each system’s ability to categorize burn wounds and compare their performance.

    Methods

    Clinical assessment of a Yorkshire pig (n=3) graded burn model was performed at 24 hours after burn injury. A commercial LSI (Periscan PIM 3, Perimed Inc.) and SFDI (OxImager RS, MI Inc.) device were used to measure hemodynamic (blood flow) and structural (reduced scattering coefficient) properties of the burn wounds. Burn severity was confirmed by histology. Additionally, both devices were used to collect preliminary data on clinical patients.

    Results

    Clinical assessments in the swine model were 83% percent accurate, while the LSI and SFDI systems were 81% and 85% percent accurate respectively. In addition to being more accurate than LSI in this study, SFDI data suggests that it can spatially resolve the heterogeneity of burn severity within a burn wound. This was not observed using the commercial LSI device. Preliminary results on clinical patients also showed both devices were capable of non-invasively predicting burn regions that would eventually require grafting.

    Conclusions

    The testing of these different imaging modalities in a controlled environment allows a direct comparison. Here we show that SFDI is capable of categorizing burn wounds in a swine model of histologically confirmed graded burn severity more accurately than clinical assessment or LSI. SFDI is also able to resolve spatial heterogeneity of burn severity within a wound. SFDI has the potential to improve clinical care with additional information related to tissue structure and function, thus aiding clinicians to make decisions on how to treat burn wounds accurately at earlier time points. Additionally, these noninvasive imaging technologies have the potential to enhance tracking of wound progression and treatment efficacy.

    Applicability of Research to Practice

    By improving diagnostic accuracy of which burn areas will require grafting, these devices may aid clinicians make appropriate treatment decisions sooner.

  • 41.
    Haj-Hosseini, Neda
    et al.
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    Richter, Johan
    Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
    Milos, Peter
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery. Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Hallbeck, Martin
    Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.
    Wårdell, Karin
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy2018In: Biomedical Optics Express, E-ISSN 2156-7085, Vol. 9, no 5, p. 2284-2296Article in journal (Refereed)
    Abstract [en]

    A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images. The median ratio of protoporphyrin IX (PpIX) fluorescence and autofluorescence (AF) in the tumor was considerably higher than the marginal zone (17.3 vs 0.9). The blood flow showed two high spots (3%) in total. The proposed setup allows simultaneous and real-time detection of tumor tissue and microvascular blood flow for tracking the vessels.

    Download full text (pdf)
    fulltext
  • 42.
    Sivaraman, Navya
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Tehrani, Simin-Nadjm
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    5G Handover: When Forward Security Breaks2023In: Proceedings of the 20th International Conference on Security and Cryptography / [ed] Sabrina De Capitani di Vimercati and Pierangela Samarati, Rome, Italy: SciTePress, Science and Technology Publications , 2023, Vol. 1, p. 503-510Conference paper (Other academic)
    Abstract [en]

    5G mobility management is dependent on a couple of complex protocols for managing handovers, based on the available network interfaces (such as Xn and N2). In our work, we focus on the 5G Xn handover procedure, as defined by the 3GPP standard. In Xn handovers, the source base station hands the user equipment (UE) over to a target base station through two different mechanisms: horizontal or vertical key derivation. To ascertain the security of these complex protocols, recent works have formally described the protocols and proved some security properties. In this work, we formulate a new property, forward security, which ensures the secrecy of future handovers following a session key exchange in one handover. Using a formal model and the Tamarin prover, we show that forward security breaks in the 5G Xn handover in presence of an untrusted base station. We also propose a solution to mitigate this counter-example with a small modification of the 3GPP Xn handover procedures based on the p erceived source base station state.

    Download full text (pdf)
    fulltext
  • 43.
    Thomson, John P.
    et al.
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road, Edinburgh, UK.
    Nestor, Colm
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
    Meehan, Richard R.
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road, Edinburgh, UK.
    5-Hydroxymethylcytosine Profiling in Human DNA2017In: Population Epigenetics: Methods and Protocols / [ed] Paul Haggarty; Kristina Harrison, Humana Press, 2017, Vol. 1589, p. 89-98Chapter in book (Refereed)
    Abstract [en]

    Since its "re-discovery" in 2009, there has been significant interest in defining the genome-wide distribution of DNA marked by 5-hydroxymethylation at cytosine bases (5hmC). In recent years, technological advances have resulted in a multitude of unique strategies to map 5hmC across the human genome. Here we discuss the wide range of approaches available to map this modification and describe in detail the affinity based methods which result in the enrichment of 5hmC marked DNA for downstream analysis.

  • 44.
    Nestor, Colm
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Lentini, Antonio
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Hägg Nilsson, Cathrine
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Gawel, Danuta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Gustafsson, Mika
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.
    Mattson, Lina
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Wang, Hui
    MD Anderson Cancer Centre, TX 77030 USA.
    Rundquist, Olof
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.
    Meehan, Richard R.
    University of Edinburgh, Scotland.
    Klocke, Bernward
    Genomatix Software GmbH, Germany.
    Seifert, Martin
    Genomatix Software GmbH, Germany.
    Hauck, Stefanie M.
    German Research Centre Environm Health GmbH, Germany.
    Laumen, Helmut
    Technical University of Munich, Germany; Technical University of Munich, Germany; Helmholtz Zentrum Munchen, Germany; Technical University of Munich, Germany; Technical University of Munich, Germany.
    Zhang, Huan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Benson, Mikael
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Allergy Center.
    5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells2016In: Cell Reports, E-ISSN 2211-1247, Vol. 16, no 2, p. 559-570Article in journal (Refereed)
    Abstract [en]

    5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, we report early and widespread 5mC/5hmC remodeling during human CD4(+) T cell differentiation ex vivo at genes and cell-specific enhancers with known T cell function. We observe similar DNA de-methylation in CD4(+) memory T cells in vivo, indicating that early remodeling events persist long term in differentiated cells. Underscoring their important function, 5hmC loci were highly enriched for genetic variants associated with T cell diseases and T-cell-specific chromosomal interactions. Extensive functional validation of 22 risk variants revealed potentially pathogenic mechanisms in diabetes and multiple sclerosis. Our results support 5hmC-mediated DNA de-methylation as a key component of CD4(+) T cell biology in humans, with important implications for gene regulation and lineage commitment.

    Download full text (pdf)
    fulltext
  • 45.
    Svensson Holm, Ann-Charlotte
    et al.
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Berg, Cecilia
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Herbertsson, Helena
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Söderström, Mats
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Hammarström, Sven
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Lindström, Eva
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Bengtsson, Torbjörn
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    5-Lipoxygenase activity is involved in platelet-induced fibroblast proliferation2006Conference paper (Refereed)
  • 46.
    Svensson Holm, Ann-Charlotte
    et al.
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Berg, Cecilia
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Herbertsson, Helena
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Söderström, Mats
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Hammarström, Sven
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Lindström, Eva
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Bengtsson, Torbjörn
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    5-Lipoxygenase activity is involved in platelet-induced fibroblast proliferation2006Conference paper (Refereed)
  • 47.
    Vogt Duberg, Johan
    et al.
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Kurilova-Palisaitiene, Jelena
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Sundin, Erik
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    5‐step approach for initiating remanufacturing (5AFIR)2023In: Business Strategy and the Environment, ISSN 0964-4733, E-ISSN 1099-0836, Vol. 32, no 7, p. 4360-4370Article in journal (Refereed)
    Abstract [en]

    Despite remanufacturing being a value-retention process capable of bringing both economic and environmental benefits to original equipment manufacturers (OEMs), the remanufacturing market is small, and the OEM share on the market is even smaller. There are trends in OEMs hesitating to initiate remanufacturing due to the lack of knowledge or often unjustified assumptions about how remanufacturing affects their business-as-usual. To further motivate OEMs to initiate remanufacturing, there is a need to extend the remanufacturing initiation theory to showcase how remanufacturing could be initiated in practice. Therefore, this paper aims to describe a remanufacturing initiation and demonstrate the initiation steps for OEMs by developing a remanufacturing initiation framework. The framework is developed based on a remanufacturing initiation led by an OEM of robotic lawn mowers. Based on the case study, a 5-step approach for initiating remanufacturing (5AFIR) framework—the remanufacturing sapphire—was developed to interpret and visualise the remanufacturing approach taken at the studied OEM. The framework steps consist of the following: (1) Select a product family, (2) involve actors prone to be impacted by remanufacturing, (3) iteratively identify prerequisites and assess the system performance, (4) develop a plan and industrialise remanufacturing, and (5) refine and validate the assessment in Step 3.

    Download full text (pdf)
    fulltext
  • 48.
    Hemdan, Tammer
    et al.
    University Hospital Uppsala, Sweden.
    Johansson, Robert
    Umeå University Hospital, Sweden.
    Jahnson, Staffan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
    Hellström, Pekka
    University Central Hospital, Oulu, Finland.
    Tasdemir, Ilker
    Central Hospital of Rogaland, Stavanger, Norway.
    Malmström, Per-Uno
    University Hospital Uppsala, Sweden.
    5-Year Outcome of a Randomized Prospective Study Comparing bacillus Calmette-Guerin with Epirubicin and Interferon-alpha 2b in Patients with T1 Bladder Cancer2014In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 191, no 5, p. 1244-1249Article in journal (Refereed)
    Abstract [en]

    Purpose: In a multicenter, prospectively randomized study we evaluated the 5-year outcomes of bacillus Calmette-Guerin alone compared to a combination of epirubicin and interferon-alpha 2b in the treatment of patients with T1 bladder cancer. Materials and Methods: Transurethral resection was followed by a second resection and bladder mapping. Stratification was for grade and carcinoma in situ. Followup entailed regular cystoscopy and cytology during the first 5 years. The end points assessed in this analysis were recurrence-free survival, time to treatment failure and progression, cancer specific survival and prognostic factors. Results: The study recruited 250 eligible patients. The 5-year recurrence-free survival rate was 38% in the combination arm and 59% in the bacillus Calmette-Guerin arm (p = 0.001). The corresponding rates for the other end points were not significantly different, as free of progression 78% and 77%, treatment failure 75% and 75%, and cancer specific survival 90% and 92%, respectively. The type of treatment, tumor size and tumor status at second resection were independent variables associated with recurrence. Concomitant carcinoma in situ was not predictive of failure of bacillus Calmette-Guerin therapy. An independent factor for treatment failure was remaining T1 stage at second resection. Conclusions: Bacillus Calmette-Guerin was more effective than the tested combination therapy. The currently recommended management with second resection and 3-week maintenance bacillus Calmette-Guerin entails a low risk of cancer specific death. More aggressive treatment in patients with infiltrative tumors at second resection might improve these results. In particular, concomitant carcinoma in situ was not a predictive factor for poor outcome after bacillus Calmette-Guerin therapy.

  • 49.
    Neumann, Hartmut P.
    et al.
    Albert Ludwigs Univ, Germany.
    Young, William F. Jr.
    Mayo Clin, NY USA.
    Krauss, Tobias
    Univ Freiburg, Germany.
    Bayley, Jean-Pierre
    Leiden Univ, Netherlands.
    Schiavi, Francesca
    IRCCS, Italy.
    Opocher, Giuseppe
    IRCCS, Italy.
    Boedeker, Carsten C.
    HELIOS Hanseklinikum Stralsund, Germany.
    Tirosh, Amit
    Tel Aviv Univ, Israel.
    Castinetti, Frederic
    Aix Marseille Univ, France; Hop Conception, France.
    Ruf, Juri
    Albert Ludwigs Univ, Germany.
    Beltsevich, Dmitry
    Endocrinol Res Ctr, Russia.
    Walz, Martin
    Kliniken Essen Mitte, Germany; Kliniken Essen Mitte, Germany.
    Groeben, Harald-Thomas
    Kliniken Essen Mitte, Germany.
    von Dobschuetz, Ernst
    Univ Hamburg, Germany.
    Gimm, Oliver
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Wohllk, Nelson
    Univ Chile, Spain.
    Pfeifer, Marija
    Univ Med Ctr Ljubljana, Slovenia.
    Lourenco, Delmar M. Jr.
    Univ Sao Paulo, Brazil.
    Peczkowska, Mariola
    Inst Cardiol, Poland.
    Patocs, Attila
    Hungarian Acad Sci, Hungary; Semmelweis Univ, Hungary.
    Ngeow, Joanne
    Nanyang Technol Univ Singapore, Singapore; Natl Canc Ctr Singapore, Singapore.
    Makay, Ozer
    Ege Univ, Turkey.
    Shah, Nalini S.
    King Edward Mem Hosp, India.
    Tischler, Arthur
    Tufts Med Ctr, MA USA; Tufts Univ, MA 02111 USA.
    Leijon, Helena
    Univ Helsinki, Finland; Helsinki Univ Hosp, Finland.
    Pennelli, Gianmaria
    Univ Padua, Italy.
    Villar Gomez de las Heras, Karina
    Serv Salud Castilla La Mancha SESCAM, Spain.
    Links, Thera P.
    Univ Groningen, Netherlands.
    Bausch, Birke
    Univ Freiburg, Germany.
    Eng, Charis
    Cleveland Clin, OH 44106 USA; Cleveland Clin, OH 44106 USA.
    65 YEARS OF THE DOUBLE HELIX Genetics informs precision practice in the diagnosis and management of pheochromocytoma2018In: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 25, no 8, p. T201-T219Article, review/survey (Refereed)
    Abstract [en]

    Although the authors of the present review have contributed to genetic discoveries in the field of pheochromocytoma research, we can legitimately ask whether these advances have led to improvements in the diagnosis and management of patients with pheochromocytoma. The answer to this question is an emphatic Yes! In the field of molecular genetics, the well-established axiom that familial (genetic) pheochromocytoma represents 10% of all cases has been overturned, with amp;gt;35% of cases now attributable to germline disease-causing mutations. Furthermore, genetic pheochromocytoma can now be grouped into five different clinical presentation types in the context of the ten known susceptibility genes for pheochromocytoma-associated syndromes. We now have the tools to diagnose patients with genetic pheochromocytoma, identify germline mutation carriers and to offer gene-informed medical management including enhanced surveillance and prevention. Clinically, we now treat an entire family of tumors of the paraganglia, with the exact phenotype varying by specific gene. In terms of detection and classification, simultaneous advances in biochemical detection and imaging localization have taken place, and the histopathology of the paraganglioma tumor family has been revised by immunohistochemical-genetic classification by gene-specific antibody immunohistochemistry. Treatment options have also been substantially enriched by the application of minimally invasive and adrenal-sparing surgery. Finally and most importantly, it is now widely recognized that patients with genetic pheochromocytoma/paraganglioma syndromes should be treated in specialized centers dedicated to the diagnosis, treatment and surveillance of this rare neoplasm.

  • 50.
    Broström, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Nursing Science.
    Johansson, Peter
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Cardiology . Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Albers, Jan
    City Hospital Ryhov.
    Wiberg, Jan
    City Hospital Ryhov.
    Svanborg, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Clinical Neurophysiology . Östergötlands Läns Landsting, Reconstruction Centre, Department of Neurophysiology UHL.
    Fridlund, Bengt
    Vaxjö University.
    6-month CPAP-treatment in a young male patient with severe obstructive sleep apnoea syndrome - A case study from the couples perspective2008In: European Journal of Cardiovascular Nursing, ISSN 1474-5151, E-ISSN 1873-1953, Vol. 7, no 2, p. 103-112Article in journal (Refereed)
    Abstract [en]

    Background: Obstructive sleep apnoea syndrome (OSAS) is independently associated with an increased risk for hypertension and cardiovascular disease. Continuous positive airway pressure (CPAP) can reduce mortality and morbidity, but low compliance rates are seen. Aim: To explore and describe the experiences of CPAP-treatment in a young male patient with severe OSAS during a 6-month period from the couples perspective.

    Methods and the case: A single case study with a phenomenographic approach was employed. Diagnostic procedures of OSAS and initiation of treatment with Auto-CPAP, humidifier and a nasal mask were performed during 4 visits. Conceptions were collected at 4 different occasions during the 6-month period (before, and 2 weeks, 3 months, and 6 months after treatment initiation) by means of interviews with a 33-year old male patient and his female partner.

    Findings: Totally 17 different structural aspects were found to fluctuate during the 6-month period in relation to; influence of stressors, social reactions and adaptation to increase compliance.

    Conclusion: An increased knowledge about the influence of stressors, the social reactions, and the adaptation can help healthcare personnel to identify and better understand concerns of other patients and spouses during different time phases of the initial 6-month period of CPAP-treatment.

1234567 1 - 50 of 18556
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf