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  • 1.
    Öberg, Eric
    et al.
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Electrical Engineering, Integrated Circuits and Systems.
    Kindeskog, Gustav
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Electrical Engineering, Integrated Circuits and Systems.
    16 GS/s Continuous-Time ΣΔ Modulator in a 22 nm SOI Process: a Simulation and Feasibility Study2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    With a reference specification model in terms of 8 GS/s Sigma Delta Modulator in a 28 nm CMOS process consuming 890 mW, the purpose with this thesis is to construct a similar and simpler model but with higher specification demands. In a 22 nm SOI process with an input signal bandwidth of 500 MHz sampled at 16 GS/s with a power consumption below 2 W, the objective is to design a Continuous-Time Sigma Delta Modulator with verified simulated functionality on a transistor level basis. This specification is accomplished - with a power consumption in total of 75 mW.

    The design methodology is divided into an integrator part along with a quantizer and feedback DAC part. A top-down strategy is carried out starting with an ideal high level Verilog-A model for the complete system, followed by a hardware implementation on transistor level.

    Download full text (pdf)
    16GSs_CT_SDM
  • 2.
    Zhang, Xuanjun
    et al.
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Xie, Yi
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Zhao, Qingrui
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Tian, Yupeng
    Department of Chemistry, Anhui University, China.
    1-D coordination polymer template approach to CdS and HgS aligned-nanowire bundles2003In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 27, no 5, p. 827-830Article in journal (Refereed)
    Abstract [en]

    A 1D inorganic coordination polymer template route was firstly developed to synthesize metal sulfide aligned-nanowire bundles. Based on this strategy, CdS and HgS aligned-nanowire bundles with high yields were successfully prepared in a water system at room temperature using KCd(NCS)3 as a soft template. The results revealed that the morphologies of the MS (M=Cd, Hg) aligned-nanowire bundles were uniform with lengths of several microns and the diameters of each single wire were ca. 10–30 nm and 60–80 nm for CdS and HgS, respectively.

  • 3.
    DeAngelis, Nicola
    et al.
    Gen Reg Hosp F Miulli, Italy; Univ Paris Est, France; Univ Paris Est, France.
    Catena, Fausto
    Univ Hosp Parma, Italy.
    Memeo, Riccardo
    Gen Reg Hosp F Miulli, Italy.
    Coccolini, Federico
    Pisa Univ Hosp, Italy.
    Martinez-Perez, Aleix
    Hosp Univ Doctor Peset, Spain.
    Romeo, Oreste M.
    Bronson Methodist Hosp, MI USA.
    De Simone, Belinda
    Ctr Hosp Poissy St Germain en Laye, France.
    Di Saverio, Salomone
    Cambridge Univ Hosp, England.
    Brustia, Raffaele
    Univ Paris Est, France; Univ Paris Est, France.
    Rhaiem, Rami
    Robert Debre Univ Hosp, France.
    Piardi, Tullio
    Robert Debre Univ Hosp, France; Troyes Hosp, France.
    Conticchio, Maria
    Gen Reg Hosp F Miulli, Italy.
    Marchegiani, Francesco
    Univ Padua, Italy.
    Beghdadi, Nassiba
    Univ Paris Est, France; Univ Paris Est, France.
    Abu-Zidan, Fikri M.
    UAE Univ, U Arab Emirates.
    Alikhanov, Ruslan
    Moscow Clin Sci Ctr, Russia.
    Allard, Marc-Antoine
    Hop Paul Brousse, France.
    Allievi, Niccolo
    Papa Giovanni Hosp XXIII, Italy.
    Amaddeo, Giuliana
    Univ Paris Est, France; Henri Mondor Univ Hosp, France.
    Ansaloni, Luca
    San Matteo Univ Hosp, Italy.
    Andersson, Roland
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
    Andolfi, Enrico
    San Donato Hosp, Italy.
    Azfar, Mohammad
    Al Rahba Hosp, U Arab Emirates.
    Bala, Miklosh
    Hadassah Hebrew Univ, Israel.
    Benkabbou, Amine
    Mohammed V Univ Rabat, Morocco.
    Ben-Ishay, Offir
    Rambam Healthcare Campus, Israel.
    Bianchi, Giorgio
    Gen Reg Hosp F Miulli, Italy.
    Biffl, Walter L.
    Scripps Mem Hosp La Jolla, CA USA.
    Brunetti, Francesco
    Univ Paris Est, France; Univ Paris Est, France.
    Carra, Maria Clotilde
    Rothschild Hosp, France; Univ Paris, France.
    Casanova, Daniel
    Univ Cantabria, Spain.
    Celentano, Valerio
    Chelsea & Westminster Hosp, England.
    Ceresoli, Marco
    Univ Milano Bicocca, Italy.
    Chiara, Osvaldo
    Univ Milan, Italy.
    Cimbanassi, Stefania
    Univ Milan, Italy.
    Bini, Roberto
    Univ Milan, Italy.
    Coimbra, Raul
    Riverside Univ, CA USA; Loma Linda Univ, CA USA.
    Luigi deAngelis, Gianm
    Univ Parma, Italy.
    Decembrino, Francesco
    Gen Reg Hosp F Miulli, Italy.
    De Palma, Andrea
    Pisa Univ Hosp, Italy.
    de Reuver, Philip R.
    Radboud Univ Nijmegen, Netherlands.
    Domingo, Carlos
    Hosp Univ Doctor Peset, Spain.
    Cotsoglou, Christian
    ASST Vimercat, Italy.
    Ferrero, Alessandro
    Azienda Osped Ordine Mauriziano Umberto I, Italy.
    Fraga, Gustavo P.
    Univ Campinas Unicamp, Brazil.
    Gaiani, Federica
    Univ Parma, Italy.
    Gheza, Federico
    Univ Brescia, Italy.
    Gurrado, Angela
    Univ Bari Aldo Moro, Italy.
    Harrison, Ewen
    Univ Edinburgh, Scotland; Univ Edinburgh, Scotland.
    Henriquez, Angel
    Ctr Medico Laparoscop, El Salvador.
    Hofmeyr, Stefan
    Univ Stellenbosch, South Africa.
    Iadarola, Roberta
    Univ Hosp Parma, Italy.
    Kashuk, Jeffry L.
    Tel Aviv Univ, Israel.
    Kianmanesh, Reza
    Robert Debre Univ Hosp, France.
    Kirkpatrick, Andrew W.
    Foothills Med Ctr, Canada.
    Kluger, Yoram
    Rambam Healthcare Campus, Israel.
    Landi, Filippo
    Univ Barcelona, Spain.
    Langella, Serena
    Azienda Osped Ordine Mauriziano Umberto I, Italy.
    Lapointe, Real
    Ctr Hosp Univ Montreal, Canada.
    Le Roy, Bertrand
    Univ Hosp St Etienne, France.
    Luciani, Alain
    Univ Paris Est, France; Henri Mondor Univ Hosp, France.
    Machado, Fernando
    Hosp Clin Montevideo, Uruguay.
    Maggi, Umberto
    Osped Maggiore Policlin Milano, Italy.
    Maier, Ronald V.
    Univ Washington, WA 98195 USA.
    Mefire, Alain Chichom
    Reg Hosp, Cameroon.
    Hiramatsu, Kazuhiro
    Toyohashi Municipal Hosp, Japan.
    Ordonez, Carlos
    Univ Valle Cali, Colombia.
    Patrizi, Franca
    Maggiore Hosp, Italy.
    Planells, Manuel
    Hosp Univ Doctor Peset, Spain.
    Peitzman, Andrew B.
    Univ Pittsburg, KS USA.
    Pekolj, Juan
    Hosp Italiano Buenos Aires, Argentina.
    Perdigao, Fabiano
    Hop La Pitie Salpetriere, France.
    Pereira, Bruno M.
    Univ Campinas Unicamp, Brazil.
    Pessaux, Patrick
    Univ Strasbourg, France.
    Pisano, Michele
    Papa Giovanni Hosp XXIII, Italy.
    Puyana, Juan Carlos
    Univ Pittsburgh, PA USA.
    Rizoli, Sandro
    St Michaels Hosp, Canada.
    Portigliotti, Luca
    Azienda Osped Univ Maggiore Carita, Italy.
    Romito, Raffaele
    Azienda Osped Univ Maggiore Carita, Italy.
    Sakakushev, Boris
    Med Univ, Bulgaria.
    Sanei, Behnam
    Isfahan Univ Med Sci, Iran.
    Scatton, Olivier
    Univ Paris Est, France; Henri Mondor Hosp, France.
    Serradilla-Martin, Mario
    Hosp Univ Miguel Servet, Spain.
    Schneck, Anne-Sophie
    Ctr Hosp Univ Guadeloupe, France.
    Sissoko, Mohammed Lamine
    Hop Natl Blaise Compaore Ouagadougou, Burkina Faso.
    Sobhani, Iradj
    Univ Paris Est, France; Henri Mondor Hosp, France.
    ten Broek, Richard P.
    Radboud Univ Nijmegen, Netherlands.
    Testini, Mario
    Univ Bari Aldo Moro, Italy.
    Valinas, Roberto
    Clin Hosp Dr Manuel Quintela, Uruguay.
    Veloudis, Giorgos
    Vet Fund Army Hosp, Greece.
    Vitali, Giulio Cesare
    Geneva Univ Hosp, Switzerland.
    Weber, Dieter
    Royal Perth Hosp, Australia.
    Zorcolo, Luigi
    Univ Cagliari, Italy.
    Giuliante, Felice
    Fdn Policlin Univ A Gemelli, Italy.
    Gavriilidis, Paschalis
    Imperial Coll HealthCare, England.
    Fuks, David
    Inst Mutualiste Montsouris, France.
    Sommacale, Daniele
    Univ Paris Est, France; Univ Paris Est, France.
    2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy2021In: World Journal of Emergency Surgery, E-ISSN 1749-7922, Vol. 16, no 1, article id 30Article, review/survey (Refereed)
    Abstract [en]

    Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.

    Download full text (pdf)
    fulltext
  • 4.
    Bergh, Torsten
    et al.
    Swedish Transport Adm, Sweden; Movea Trafikkonsult, Sweden.
    Remgard, Mats
    Swedish Transport Adm, Sweden.
    Carlsson, Arne
    Swedish National Rd and Transport Research Institute, Linköping, Sweden.
    Olstam, Johan
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering. Swedish National Road and Transport Research Institute, Linköping, Sweden.
    Strömgren, Per
    Movea Trafikkonsult, Sweden.
    2+1-roads Recent Swedish Capacity and Level-of-Service Experience2016In: INTERNATIONAL SYMPOSIUM ON ENHANCING HIGHWAY PERFORMANCE (ISEHP), (7TH INTERNATIONAL SYMPOSIUM ON HIGHWAY CAPACITY AND QUALITY OF SERVICE, 3RD INTERNATIONAL SYMPOSIUM ON FREEWAY AND TOLLWAY OPERATIONS), ELSEVIER SCIENCE BV , 2016, Vol. 15, p. 331-345Conference paper (Refereed)
    Abstract [en]

    The first Swedish 2+1 median barrier road was opened in 1998. The concept was to retrofit the standard existing two-lane 13 m paved width cross-section at 90 and 110 kph posted speed limit without widening. This design has one continuous lane in each direction, a middle lane changing direction every one to three kilometres with a median barrier separating the two traffic directions. Today over 2 700 km 2+1 median barrier roads are opened for traffic. AADTs vary from some 3 000 to 20 000 with an average just below 10 000 nowadays normally with 100 kph. The concept has lately been enhanced also to cover the existing 9 m paved width cross-section. The design concept is the same from a drivers viewpoint, one continuous lane in each direction with a middle lane changing direction and a separating median barrier. This is created by introducing a continuous median barrier and adding overtaking lanes within an overtaking strategy. The differences are the existence of 1+1-sections, less overtaking opportunities and a slightly more narrow cross-section. Some 15 projects are opened. The purpose of this paper is to summarize present knowledge on level-of-service issues as they are presented in Swedish design and assessment guidelines and to give an overview of field measurements and theoretical analytical and simulation studies supporting the recommendations.

    Download full text (pdf)
    fulltext
  • 5.
    Heimann, Mikael
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Hedendahl, Louise
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Ottmer, Elida
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Kolling, Thorsten
    Univ Siegen, Germany.
    Koch, Felix-Sebastian
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Birberg Thornberg, Ulrika
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Sundqvist, Anett (Annette)
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    2-Year-Olds Learning From 2D Media With and Without Parental Support: Comparing Two Forms of Joint Media Engagement With Passive Viewing and Learning From 3D2021In: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 11, article id 576940Article in journal (Refereed)
    Abstract [en]

    The study investigates to what degree two different joint media engagement (JME) strategies affect childrens learning from two-dimensional (2D)-media. More specifically, we expected an instructed JME strategy to be more effective than a spontaneous, non-instructed, JME strategy. Thirty-five 2-year old children saw a short video on a tablet demonstrating memory tasks together with a parent. The parents were randomized into two groups: One group (N = 17) was instructed to help their child by describing the actions they saw on the video while the other group (N = 18) received no specific instruction besides "do as you usually do." The parents in the instructed group used significantly more words and verbs when supporting their child but both groups of children did equally well on the memory test. In a second step, we compared the performance of the two JME groups with an opportunistic comparison group (N = 95) tested with half of the memory tasks live and half of the tasks on 2D without any JME support. Results showed that the JME intervention groups received significantly higher recall scores than the no JME 2D comparison group. In contrast, the three-dimensional (3D) comparison group outperformed both JME groups. In sum, our findings suggest that JME as implemented here is more effective in promoting learning than a no JME 2D demonstration but less so than the standard 3D presentation of the tasks.

    Download full text (pdf)
    fulltext
  • 6.
    Li, Senmao
    et al.
    Nankai Univ, Peoples R China.
    van de Weijer, Joost
    Univ Autonoma Barcelona, Spain.
    Wang, Yaxing
    Nankai Univ, Peoples R China.
    Khan, Fahad
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, Faculty of Science & Engineering. Mohamed bin Zayed Univ AI, U Arab Emirates.
    Liu, Meiqin
    Beijing Jiaotong Univ, Peoples R China.
    Yang, Jian
    Nankai Univ, Peoples R China.
    3D-Aware Multi-Class Image-to-Image Translation with NeRFs2023In: 2023 IEEE/CVF CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR), IEEE COMPUTER SOC , 2023, p. 12652-12662Conference paper (Refereed)
    Abstract [en]

    Recent advances in 3D-aware generative models (3D-aware GANs) combined with Neural Radiance Fields (NeRF) have achieved impressive results. However no prior works investigate 3D-aware GANs for 3D consistent multi-class image-to-image (3D-aware I2I) translation. Naively using 2D-I2I translation methods suffers from unrealistic shape/identity change. To perform 3D-aware multi-class I2I translation, we decouple this learning process into a multi-class 3D-aware GAN step and a 3D-aware I2I translation step. In the first step, we propose two novel techniques: a new conditional architecture and an effective training strategy. In the second step, based on the well-trained multi-class 3D-aware GAN architecture, that preserves view-consistency, we construct a 3D-aware I2I translation system. To further reduce the view-consistency problems, we propose several new techniques, including a U-net-like adaptor network design, a hierarchical representation constrain and a relative regularization loss. In extensive experiments on two datasets, quantitative and qualitative results demonstrate that we successfully perform 3D-aware I2I translation with multi-view consistency. Code is available in 3DI2I.

  • 7.
    Yasin, M. Naveed
    et al.
    Univ Auckland, New Zealand; Univ Auckland, New Zealand.
    Brooke, Robert
    Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering. Univ South Australia, Australia.
    Rudd, Sam
    Univ South Australia, Australia.
    Chan, Andrew
    Univ Auckland, New Zealand.
    Chen, Wan-Ting
    Univ Auckland, New Zealand.
    Waterhouse, Geoffrey I. N.
    Univ Auckland, New Zealand; Univ Auckland, New Zealand.
    Evans, Drew
    Univ South Australia, Australia.
    Rupenthal, Ilva D.
    Univ Auckland, New Zealand.
    Svirskis, Darren
    Univ Auckland, New Zealand.
    3-Dimensionally ordered macroporous PEDOT ion-exchange resins prepared by vapor phase polymerization for triggered drug delivery: Fabrication and characterization2018In: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 269, p. 560-570Article in journal (Refereed)
    Abstract [en]

    This paper reports a simple fabrication strategy towards 3-dimensionally ordered macroporous (3DOM) poly(3,4-ethylenedioxythiophene) (PEDOT) thin films via vapor phase polymerization (VPP) coupled with colloidal crystal templating. PEDOT was synthesized by VPP over a colloidal crystal thin film composed of monodisperse polystyrene colloids functionalized with a Fe(III) tosylate catalyst, after which the polystyrene template was selectively removed. The resulting 3DOM PEDOT films comprised a face-centered cubic array of 280-290 nm spherical macropores in a PEDOT matrix, around 5-6 mu m thick. Cyclic voltammetry (CV) was used to probe electrochemistry and highlighted the merits of the fabrication strategy introduced here; the 3DOM PEDOT films exhibit a 2.9-fold increase in electrochemically available surface area compared to the non-templated PEDOT films. As a demonstration of functionality, ion-exchange of the dopant tosylate for the anionic drug dexamethasone phosphate (dexP(-)) was explored. Loading by passive ion exchange was three-fold higher for 3DOM PEDOT compared with non-templated PEDOT. Notably, CV-driven ion exchange was more efficient to load drug into the polymer than passive ion exchange, and occurred to similar extents for both non-templated PEDOT and 3DOM PEDOT structures. Following loading, minimal dexP(-) release was observed in the absence of an electrical stimulus, while dexP(-) release was triggered upon application of a suitable electrical stimulus. 3DOM PEDOT prepared by VPP thus represents a promising material for use as an ion exchange resin with drug loading achieved subsequent to polymerization and electrically triggered drug release demonstrated. (c) 2018 Elsevier Ltd. All rights reserved.

  • 8.
    Ghorbani Shiraz, Hamid
    et al.
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Ullah Khan, Zia
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Pere, Daniel
    IMRA Europe SAS, France.
    Liu, Xianjie
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Coppel, Yannick
    Univ Toulouse, France.
    Fahlman, Mats
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Berggren, Magnus
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Chmielowski, Radoslaw
    IMRA Europe SAS, France.
    Kahn, Myrtil L.
    Univ Toulouse, France.
    Vagin, Mikhail
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Crispin, Xavier
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    3R-TaS2 as an Intercalation-Dependent Electrified Interface for Hydrogen Reduction and Oxidation Reactions2022In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 126, no 40, p. 17056-17065Article in journal (Refereed)
    Abstract [en]

    Hydrogen technology, as a future breakthrough for the energy industry, has been defined as an environmentally friendly, renewable, and high-power energy carrier. The green production of hydrogen, which mainly relies on electrocatalysts, is limited by the high cost and/ or the performance of the catalytic system. Recently, studies have been conducted in search of bifunctional electrocatalysts accelerating both the hydrogen evolution reaction (HER) and the hydrogen oxidation reaction (HOR). Herein, we report the investigation of the high efficiency bifunctional electrocatalyst TaS2 for both the HER and the HOR along with the asymmetric effect of inhibition by organic intercalation. The linear organic agent, to boost the electron donor property and to ease the process of intercalation, provides a higher interlayer gap in the tandem structure of utilized nanosheets. XRD and XPS data reveal an increase in the interlayer distance of 22%. The HER and the HOR were characterized in a Pt group metal-free electrochemical system. The pristine sample shows a low overpotential of -0.016 Vat the onset. The intercalated sample demonstrates a large shift in its performance for the HER. It is revealed that the intercalation is a potential key strategy for tuning the performance of this family of catalysts. The inhibition of the HER by intercalation is considered as the increase in the operational window of a water-based electrolyte on a negative electrode, which is relevant to technologies of electrochemical energy storage.

    Download full text (pdf)
    fulltext
  • 9.
    Örtegren Kugelberg, Unn
    et al.
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
    Nätt, Daniel
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
    Skog, Signe
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
    Kutter, Claudia
    Karolinska Inst, Sweden.
    Öst, Anita
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
    5 XP sRNA-seq: efficient identification of transcripts with and without 5 phosphorylation reveals evolutionary conserved small RNA2021In: RNA Biology, ISSN 1547-6286, E-ISSN 1555-8584, Vol. 18, no 11, p. 1588-1599Article in journal (Refereed)
    Abstract [en]

    Small RNA (sRNA) sequencing has been critical for our understanding of many cellular processes, including gene regulation. Nonetheless, the varying biochemical properties of sRNA, such as 5 nucleotide modifications, make many sRNA subspecies incompatible with common protocols for sRNA sequencing. Here we describe 5XP-seq that outlines a novel strategy that captures a more complete picture of sRNA. By tagging 5 P sRNA during library preparation, 5XP-seq combines an open approach that includes all types of 5MODIFIER LETTER PRIME-terminal modifications (5 X), with a selective approach for 5-phosphorylated sRNA (5 P). We show that 5XP-seq not only enriches phosphorylated miRNA and piRNA but successfully discriminates these sRNA from all other sRNA species. We further demonstrate the importance of this strategy by successful inter-species validation of sRNAs that would have otherwise failed, including human to insect translation of several tRNA (tRFs) and rRNA (rRFs) fragments. By combining 5 insensitive library strategies with 5 sensitive tagging, we have successfully tackled an intrinsic bias in modern sRNA sequencing that will help us reveal the true complexity and the evolutionary significance of the sRNA world.

  • 10.
    Vogt Duberg, Johan
    et al.
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Kurilova-Palisaitiene, Jelena
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Sundin, Erik
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    5‐step approach for initiating remanufacturing (5AFIR)2023In: Business Strategy and the Environment, ISSN 0964-4733, E-ISSN 1099-0836, Vol. 32, no 7, p. 4360-4370Article in journal (Refereed)
    Abstract [en]

    Despite remanufacturing being a value-retention process capable of bringing both economic and environmental benefits to original equipment manufacturers (OEMs), the remanufacturing market is small, and the OEM share on the market is even smaller. There are trends in OEMs hesitating to initiate remanufacturing due to the lack of knowledge or often unjustified assumptions about how remanufacturing affects their business-as-usual. To further motivate OEMs to initiate remanufacturing, there is a need to extend the remanufacturing initiation theory to showcase how remanufacturing could be initiated in practice. Therefore, this paper aims to describe a remanufacturing initiation and demonstrate the initiation steps for OEMs by developing a remanufacturing initiation framework. The framework is developed based on a remanufacturing initiation led by an OEM of robotic lawn mowers. Based on the case study, a 5-step approach for initiating remanufacturing (5AFIR) framework—the remanufacturing sapphire—was developed to interpret and visualise the remanufacturing approach taken at the studied OEM. The framework steps consist of the following: (1) Select a product family, (2) involve actors prone to be impacted by remanufacturing, (3) iteratively identify prerequisites and assess the system performance, (4) develop a plan and industrialise remanufacturing, and (5) refine and validate the assessment in Step 3.

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  • 11.
    Lagerqvist, Bo
    et al.
    Uppsala.
    Husted, Steen
    Århus,Danmark.
    Koontny, Fredrik
    Oslo, Norge.
    Ståhle, Elisabeth
    Uppsala.
    Swahn, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Wallentin, Lars
    Uppsala.
    5-year outcomes in the FRISC-II randomised trial of an invasive versus a non-invasive strategy in non-ST-elevation acute coronary syndrome: a follow-up study2006In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 368, no 9540, p. 998-1004Article in journal (Refereed)
    Abstract [en]

    Background: The FRISC-II invasive trial compared an early invasive with a non-invasive strategy in terms of death and myocardial infarction in non-ST-elevation acute coronary syndrome. We present 5-year follow-up results, overall and in subgroups based on recommended risk stratification criteria. Methods: In the FRISC-II trial, 2457 patients with non-ST-elevation acute coronary syndrome were randomised to early invasive strategy (coronary angiography and, if appropriate, revascularisation, within 7 days from admission) or non-invasive primarily medical strategy. Risk stratification was done on the basis of risk indicators at randomisation: age older than 65 years, male sex, diabetes mellitus, previous myocardial infarction, ST-segment depression, raised troponin concentration (>0·03 μg/L), and raised C-reactive protein or interleukin 6. Information on events after 24 months was taken from national registries. Analyses were done on an intention-to-treat basis. Findings: At 5 years the groups differed in terms of the primary composite endpoint of death, myocardial infarction, or both (invasive 217, 19·9 %, noninvasive 270, 24·5 %, risk ratio 0·81, 95% CI 0·69-0·95, p=0·009). 5-year mortality was 117 (9·7%) in the invasive group compared with 124 (10·1%) in the noninvasive group (0·95, 0·75 -1·21, p=0·693). Rates of myocardial infarction were 141 (12·9 %) in the invasive and 195 (17.7%) in the non-invasive group (0·73, 0·60-0·89, p=0·002). The benefit of the invasive strategy was confined to male patients, non-smokers, and patients with two or more risk indicators. Interpretation: The 5-year outcome of this trial indicates sustained benefit of an early invasive strategy in patients with non-ST-elevation acute coronary syndrome at moderate to high risk. © 2006 Elsevier Ltd. All rights reserved.

  • 12.
    Gotberg, Matthias
    et al.
    Lund Univ, Sweden.
    Berntorp, Karolina
    Lund Univ, Sweden.
    Rylance, Rebecca
    Lund Univ, Sweden.
    Christiansen, Evald H.
    Aarhus Univ Hosp, Denmark.
    Yndigegn, Troels
    Lund Univ, Sweden.
    Gudmundsdottir, Ingibjorg J.
    Univ Iceland, Iceland.
    Koul, Sasha
    Lund Univ, Sweden.
    Sandhall, Lennart
    Helsingborg Cty Hosp, Sweden.
    Danielewicz, Mikael
    Karlstad Cent Hosp, Sweden.
    Jakobsen, Lars
    Aarhus Univ Hosp, Denmark.
    Olsson, Sven-Erik
    Helsingborg Cty Hosp, Sweden.
    Olsson, Hans
    Karlstad Cent Hosp, Sweden.
    Omerovic, Elmir
    Sahlgrens Univ Hosp, Sweden.
    Calais, Fredrik
    Orebro Univ Hosp, Sweden; Aarhus Univ Hlth, Denmark; Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark.
    Lindroos, Pontus
    St Goran Hosp, Sweden.
    Maeng, Michael
    Aarhus Univ Hosp, Denmark.
    Venetsanos, Dimitrios
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart Center, Department of Cardiology in Linköping.
    James, Stefan K.
    Uppsala Univ, Sweden.
    Karegren, Amra
    Vastmanland Hosp, Sweden.
    Carlsson, Jorg
    Kalmar Hosp, Sweden.
    Jensen, Jens
    Karolinska Inst, Sweden.
    Karlsson, Ann-Charlotte
    Halmstad Cty Hosp, Sweden.
    Erlinge, David
    Lund Univ, Sweden.
    Frobert, Ole
    Orebro Univ Hosp, Sweden; Aarhus Univ Hlth, Denmark; Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark.
    5-Year Outcomes of PCI Guided by Measurement of Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve2022In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 79, no 10, p. 965-974Article in journal (Refereed)
    Abstract [en]

    BACKGROUND Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking. OBJECTIVES The purpose of this study was to investigate the prespecified 5-year follow-up of the primary composite outcome of all-cause mortality, myocardial infarction, and unplanned revascularization of the iFR-SWEDEHEART trial comparing iFR vs FFR in patients with chronic and acute coronary syndromes. METHODS iFR-SWEDEHEART was a multicenter, controlled, open-label, registry-based randomized clinical trial using the Swedish Coronary Angiography and Angioplasty Registry for enrollment. A total of 2,037 patients were randomized to undergo revascularization guided by iFR or FFR. RESULTS No patients were lost to follow-up. At 5 years, the rate of the primary composite endpoint was 21.5% in the iFR group and 19.9% in the FFR group (HR: 1.09; 95% CI: 0.90-1.33). The rates of all-cause death (9.4% vs 7.9%; HR: 1.20; 95% CI: 0.89-1.62), nonfatal myocardial infarction (5.7% vs 5.8%; HR: 1.00; 95% CI: 0.70-1.44), and unplanned revascularization (11.6% vs 11.3%; HR: 1.02; 95% CI: 0.79-1.32) were also not different between the 2 groups. The outcomes were consistent across prespecified subgroups. CONCLUSIONS In patients with chronic or acute coronary syndromes, an iFR-guided revascularization strategy was associated with no difference in the 5-year composite outcome of death, myocardial infarction, and unplanned revascularization compared with an FFR-guided revascularization strategy. (Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome [iFR SWEDEHEART]; NCT02166736) (J Am Coll Cardiol 2022;79:965-974) (c) 2022 by the American College of Cardiology Foundation.

  • 13.
    Johansson, Ted
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Bengtsson, Olof
    Lotfi, Sara
    Uppsala University, Sweden.
    Vestling, Lars
    Uppsala University, Sweden.
    Norström, Hans
    Uppsala University, Sweden.
    Olsson, Jörgen
    Uppsala University, Sweden.
    Nyström, Christian
    A +32.8 dBm LDMOS power amplifier for WLAN in 65 nm CMOS technology2013Conference paper (Refereed)
    Abstract [en]

    Postlingually acquired hearing impairment (HI) is associated with changes in the representation of sound in semantic long-term memory. An indication of this is the lower performance on visual rhyme judgment tasks in conditions where phonological and orthographic cues mismatch, requiring high reliance on phonological representations. In this study, event-related potentials (ERPs) were used for the first time to investigate the neural correlates of phonological processing in visual rhyme judgments in participants with acquired HI and normal hearing (NH). Rhyme task word pairs rhymed or not and had matching or mismatching orthography. In addition, the inter-stimulus interval (ISI) was manipulated to be either long (800 ms) or short (50 ms). Long ISIs allow for engagement of explicit, top-down processes, while short ISIs limit the involvement of such mechanisms. We hypothesized lower behavioral performance and N400 and N2 deviations in HI in the mismatching rhyme judgment conditions, particularly in short ISI. However, the results showed a different pattern. As expected, behavioral performance in the mismatch conditions was lower in HI than in NH in short ISI, but ERPs did not differ across groups. In contrast, HI performed on a par with NH in long ISI. Further, HI, but not NH, showed an amplified N2-like response in the non-rhyming, orthographically mismatching condition in long ISI. This was also the rhyme condition in which participants in both groups benefited the most from the possibility to engage top-down processes afforded with the longer ISI. Taken together, these results indicate an early ERP signature of HI in this challenging phonological task, likely reflecting use of a compensatory strategy. This strategy is suggested to involve increased reliance on explicit mechanisms such as articulatory recoding and grapheme-to-phoneme conversion.

  • 14.
    Garrido Gálvez, Mario
    et al.
    Linköping University, Department of Electrical Engineering, Computer Engineering. Linköping University, Faculty of Science & Engineering.
    Angel Sanchez, Miguel
    University of Politecn Madrid, Spain.
    Luisa Lopez-Vallejo, Maria
    University of Politecn Madrid, Spain.
    Grajal, Jesus
    University of Politecn Madrid, Spain.
    A 4096-Point Radix-4 Memory-Based FFT Using DSP Slices2017In: IEEE Transactions on Very Large Scale Integration (vlsi) Systems, ISSN 1063-8210, E-ISSN 1557-9999, Vol. 25, no 1, p. 375-379Article in journal (Refereed)
    Abstract [en]

    This brief presents a novel 4096-point radix-4 memory-based fast Fourier transform (FFT). The proposed architecture follows a conflict-free strategy that only requires a total memory of size N and a few additional multiplexers. The control is also simple, as it is generated directly from the bits of a counter. Apart from the low complexity, the FFT has been implemented on a Virtex-5 field programmable gate array (FPGA) using DSP slices. The goal has been to reduce the use of distributed logic, which is scarce in the target FPGA. With this purpose, most of the hardware has been implemented in DSP48E. As a result, the proposed FPGA is efficient in terms of hardware resources, as is shown by the experimental results.

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  • 15.
    Zhang, Dai
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Bhide, Ameya
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A 53-nW 9.12-ENOB 1-kS/s SAR ADC in 0.13-um CMOS for medical implant devices2011In: Proceedings of the IEEE European Solid-State Circuits Conference (ESSCIRC), Helsinki, Finland: IEEE Solid-State Circuits Society, 2011, p. 467-470Conference paper (Refereed)
    Abstract [en]

    This paper describes an ultra-low-power SAR ADC in 0.13-um CMOS technology for medical implant devices. It utilizes an ultra-low-power design strategy, imposing maximum simplicity in ADC architecture, low transistor count, low-voltage low-leakage circuit techniques, and matched capacitive DAC with a switching scheme which results in full-range sampling without switch bootstrapping and extra reset voltage. Furthermore, a dual-supply scheme allows the SAR logic to operate at 400mV. The ADC has been fabricated in 0.13-um CMOS. In 1.0-V single-supply mode, the ADC consumes 65nW at a sampling rate of 1kS/s, while in dual-supply mode (1.0V for analog and 0.4V for digital) it consumes 53nW (18% reduction) and achieves the same ENOB of 9.12. 24% of the 53-nW total power is due to leakage. To the authors' best knowledge, this is the lowest reported power consumption of a 10-bit ADC for such sampling rates.

  • 16.
    Zhang, Dai
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Bhide, Ameya
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A 53-nW 9.1-ENOB 1-kS/s SAR ADC in 0.13-μm CMOS for Medical Implant Devices2012In: IEEE Journal of Solid-State Circuits, ISSN 0018-9200, E-ISSN 1558-173X, Vol. 47, no 7, p. 1585-1593Article in journal (Refereed)
    Abstract [en]

    This paper describes an ultra-low power SAR ADC for medical implant devices. To achieve the nano-watt range power consumption, an ultra-low power design strategy has been utilized, imposing maximum simplicity on the ADC architecture, low transistor count and matched capacitive DAC with a switching scheme which results in full-range sampling without switch boot-strapping and extra reset voltage. Furthermore, a dual-supply voltage scheme allows the SAR logic to operate at 0.4 V, reducing the overall power consumption of the ADC by 15% without any loss in performance. The ADC was fabricated in 0.13-mu m CMOS. In dual-supply mode (1.0 V for analog and 0.4 V for digital), the ADC consumes 53 nW at a sampling rate of 1 kS/s and achieves the ENOB of 9.1 bits. The leakage power constitutes 25% of the 53-nW total power.

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  • 17.
    Zhang, Yingfeng
    et al.
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China.
    Ren, Shan
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China; Department of Mechanical Engineering, Honghe University, Yunnan, PR China.
    Liu, Yang
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering. Department of Production, University of Vaasa, Vaasa, Finland.
    Si, Shubin
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China.
    A big data analytics architecture for cleaner manufacturing and maintenance processes of complex products2017In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 142, no 2, p. 626-641Article in journal (Refereed)
    Abstract [en]

    Cleaner production (CP) is considered as one of the most important means for manufacturing enterprises to achieve sustainable production and improve their sustainable competitive advantage. However, implementation of the CP strategy was facing barriers, such as the lack of complete data and valuable knowledge that can be employed to provide better support on decision-making of coordination and optimization on the product lifecycle management (PLM) and the whole CP process. Fortunately, with the wide use of smart sensing devices in PLM, a large amount of real-time and multi-source lifecycle big data can now be collected. To make better PLM and CP decisions based on these data, in this paper, an overall architecture of big data-based analytics for product lifecycle (BDA-PL) was proposed. It integrated big data analytics and service-driven patterns that helped to overcome the above-mentioned barriers. Under the architecture, the availability and accessibility of data and knowledge related to the product were achieved. Focusing on manufacturing and maintenance process of the product lifecycle, and the key technologies were developed to implement the big data analytics. The presented architecture was demonstrated by an application scenario, and some observations and findings were discussed in details. The results showed that the proposed architecture benefited customers, manufacturers, environment and even all stages of PLM, and effectively promoted the implementation of CP. In addition, the managerial implications of the proposed architecture for four departments were analyzed and discussed. The new CP strategy provided a theoretical and practical basis for the sustainable development of manufacturing enterprises.

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  • 18.
    Zhang, Yingfeng
    et al.
    Northwestern Polytech Univ, Peoples R China.
    Ma, Shuaiyin
    Northwestern Polytech Univ, Peoples R China.
    Yang, Haidong
    Guangdong Univ Technol, Peoples R China.
    Lv, Jingxiang
    Northwestern Polytech Univ, Peoples R China.
    Liu, Yang
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering. Univ Vaasa, Finland.
    A big data driven analytical framework for energy-intensive manufacturing industries2018In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 197, p. 57-72Article in journal (Refereed)
    Abstract [en]

    Energy-intensive industries account for almost 51% of energy consumption in China. A continuous improvement in energy efficiency is important for energy-intensive industries. Cleaner production has proven itself as an effective way to improve energy efficiency and reduce energy consumption. However, there is a lack of manufacturing data due to the difficult implementation of sensors in harsh production environment, such as high temperature, high pressure, high acid, high alkali, and smoky environment which hinders the implementation of the cleaner production strategy. Thanks to the rapid development of the Internet of Things, many data can be sensed and collected in the manufacturing processes. In this paper, a big data driven analytical framework is proposed to reduce the energy consumption and emission for energy-intensive manufacturing industries. Then, two key technologies of the proposed framework, namely energy big data acquisition and energy big data mining, are utilized to implement energy big data analytics. Finally, an application scenario of ball mills in a pulp workshop of a partner company is presented to demonstrate the proposed framework. The results show that the energy consumption and energy costs are reduced by 3% and 4% respectively. These improvements can promote the implementation of cleaner production strategy and contribute to the sustainable development of energy intensive manufacturing industries.

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  • 19.
    Edström, Kristina
    et al.
    School of Education and Communication in Engineering Science, KTH Royal Institute of Technology, Stockholm, Sweden.
    Kolmos, Anette
    Department of Development and Planning, Aalborg University, Aalborg, Denmark.
    Malmi, Lauri
    Department of Computer Science, Aalto University, Helsinki, Finland.
    Bernhard, Jonte
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Andersson, Pernille
    LearningLab DTU, Technical University of Denmark, Kgs. Lyngby, Denmark.
    A bottom-up strategy for establishment of EER in three Nordic countries: The role of networks2018In: European Journal of Engineering Education, ISSN 0304-3797, E-ISSN 1469-5898, Vol. 43, no 2, p. 219-234Article in journal (Refereed)
    Abstract [en]

    This paper investigates the emergence of an engineering education research (EER) community in three Nordic countries: Denmark, Finland and Sweden. First, an overview of the current state of Nordic EER authorship is produced through statistics on international publication. Then, the history of EER and its precursor activities is described in three national narratives. These national storylines are tied together in a description of recent networking activities, aiming to strengthen the EER communities on the Nordic level. Taking these three perspectives together, and drawing on concepts from community of practice theory, network theory and learning network theory, we discuss factors behind the differences in the countries, and draw some conclusions about implications for networking activities in a heterogeneous community. Further, we discuss the role of networks for affording a joint identity.

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  • 20.
    Gürtler, Paula
    Linköping University, Department of Culture and Society.
    A Capabilities Approach to Late Modernity: Flexibility, Singularity, and Human Flourishing in the Labor Market2022Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In my paper, I argue that the underlying social ideals of the late modern labor market, namely flexibility and singularity, undermine human flourishing as conceptualized by Martha C. Nussbaum. It is on these grounds, that we should be critical of late modernity. For an account of late modernity, I rely on the sociological works of Ulrich Beck (1992), Zygmunt Bauman (2000; 2007a), and Andreas Reckwitz (Reckwitz & Pakis, 2020). My account of this socio-historical era focusses on the three main components that set it apart from the previous industrial modernity according to the aforementioned sociologists: the revolution in ICT, the creative economy, and the socio-cultural revolution within the new middle class. It becomes clear that these three components contribute to a more liquid, flexible, and singularized setting. On this basis, then, I will introduce the ethical theory of Martha C. Nussbaum: The Capabilities Approach. I will justify the methodological choice of using her theory, and not that the Capabilities approach of Amartya Sen. My focus on human flourishing will be defended against the accusation of being universalist or biased, and the suggestion that preference utilitarianism would be a better fit for my research objective. 

    The main body of my paper is the ethical analysis and weighing of arguments for and against my thesis, that we ought to object to the social ideals promoted by the late modern labor market because they undermine human flourishing. I will give two main arguments in support of this thesis, each corresponding to one of Nussbaum's central Capabilities. The first one identifies a conflict between the requirements for our emotional Capability and the kind of self-sufficiency needed to achieve the social ideal of flexibility. I show, that flexibility has become a necessary coping strategy for the late modern individual, making the conflict a pressing one to solve. My second argument draws out a lack of respect and dignity granted to those who perform functional labor (mostly in the service sector) in late modernity, because the functional worker can not live up to the social ideal of singularity. The lack of respect for functional workers pushes them below the threshold required for human flourishing. Finally, I will consider the counterargument, that the late modern labor market provides better opportunities for creative expression and self-actualization. Is that not the epitome of human flourishing i.e. the actualization of one's potentialities? However, I refute this counterargument on multiple grounds: firstly, the goal is not human flourishing, but economic profit. Secondly, it promotes a kind of consumerism, that seems to conflict with emotional needs. Lastly, the workers who are enabled creative expression, are and will remain few.

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  • 21.
    Sundin, Elisabeth
    et al.
    Linköping University, HELIX Vinn Excellence Centre. Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Hedlund, Gun
    A characteristic strategy of the period2012In: Gender Mainstreaming as a Sustainable Process / [ed] Lindholm, Kristina.Lindholm, Kristina.Sjöberg, Karin.Svensson, Lennart, Studentlitteratur, 2012, p. 249-270Chapter in book (Other academic)
  • 22.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    A Classification of Different Strategic Roles of Logistics2012Conference paper (Other academic)
  • 23.
    Brude, Frida
    et al.
    Linköping University, Department of Culture and Society.
    Öhman Ekman, Alice
    Linköping University, Department of Culture and Society.
    A Closer Look at Reading Strategies in the Swedish Syllabus for English as a Second Language: A Literature Review on Strategies for Reading in Upper Secondary School in Sweden2021Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Given the importance of reading in life, it is worrying that reading comprehension as well as the interest in reading among Swedish students, especially older students, have decreased during the 21st century. One way of addressing this problem is the explicit teaching of reading strategies, which has proven effective in improving reading comprehension and is supported by the revised English as a Second Language (ESL) syllabus published by the Swedish National Agency for Education (SNAE) – effective as of 1 July 2021. This systematic literature review aims to examine the reading strategies mentioned in the revised syllabus and what these can entail in practice. This is done by comparing them to reading strategies investigated in previous research and investigating the didactic and pedagogical consequences that can arise in the teaching as a result of the wording in the ESL syllabus. The results of this research review were sorted into the following categories of strategies: visualising, retelling, predicting content, posing questions, taking notes, identifying main ideas and inferencing, and associating and using prior knowledge. The results show that the wording in the ESL syllabus, as it stands, complicates interpretations for teachers, but that the strategies can be described using research independent from SNAE, somewhat facilitating the actual use of the syllabus for working teachers. It can, however, not be assumed that teachers do this with their limited time. The results also show that education among teachers on reading strategies, at least in L2, is inadequate, affecting the quality of reading strategy teaching and the reading comprehension of students. Thus, it is of importance that teachers obtain knowledge of the teaching of reading strategies, suitably during their studies at the teacher education programme. Future research could benefit from investigating the actual use of reading strategies in classrooms, comparing reading strategies in ESL to other subjects, or looking into textbooks’ use of reading strategies.

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    Brude & Öhman Ekman
  • 24.
    Johansson, Linda
    et al.
    Linköping University, Department of Science and Technology.
    Kruse, Björn
    Linköping University, Department of Science and Technology, Digital Media. Linköping University, The Institute of Technology.
    A Colour Separation Strategy for Reproduction of Printed Dynamic Images on Paper Substrate2005In: iarigai Research Conference,2005, Zagreb: Iarigai , 2005, p. 191-Conference paper (Refereed)
  • 25.
    Xie, Yi
    et al.
    Wuhan Engineering Consulting Bureau, Wuhan, China.
    Takala, Josu
    Faculty of TechnologyUniversity of Vaasa, Vaasa, Finland.
    Liu, Yang
    Faculty of TechnologyUniversity of Vaasa, Vaasa, Finland.
    Chen, Yong
    Old Dominion University, Norfolk, USA.
    A combinatorial optimization model for enterprise patent transfer2015In: Information technology & management, ISSN 1385-951X, Vol. 16, no 4, p. 327-337Article in journal (Refereed)
    Abstract [en]

    Enterprises need patent transfer strategies to improve their technology management. This paper proposes a combinatorial optimization model that is based on intelligent computing to support enterprises’ decision making in developing patent transfer strategy. The model adopts the Black–Scholes Option Pricing Model and Arbitrage Pricing Theory to estimate a patent’s value. Based on the estimation, a hybrid genetic algorithm is applied that combines genetic algorithms and greedy strategy for the optimization purpose. Encode repairing and a single-point crossover are applied as well. To validate this proposed model, a case study is conducted. The results indicate that the proposed model is effective for achieving optimal solutions. The combinatorial optimization model can help enterprise promote their benefits from patent sale and support the decision making process when enterprises develop patent transfer strategies.

  • 26.
    Hildebrand, Cisilia
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Hörtin, Stina
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    A comparative study between Emme and Visum with respect to public transport assignment2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Macroscopic traffic simulations are widely used in the world in order to provide assistance in the traffic infrastructure development as well as for the strategic traffic planning. When studying a large traffic network macroscopic traffic simulation can be used to model current and future traffic situations. The two most common software used for traffic simulation in Sweden today are Emme and Visum, developed by INRO respective PTV.

    The aim of the thesis is to perform a comparison between the software Emme and Visum with respect to the assignment of public transport, in other words how passengers choose their routes on the existing public transport lines. However, in order to make a complete software comparison the run-time, analysis capabilities, multi-modality, capacity to model various behavioural phenomena like crowding, fares etc. this will not be done in this comparison. It is of interest to study the differences between the two software algorithms and why they might occur because the Swedish Transport Administration uses Emme and the Traffic Administration in Stockholm uses Visum when planning public transport. The comparison will include the resulting volumes on transit lines, travel times, flow through specific nodes, number of boarding, auxiliary volumes and number of transits. The goal of this work is to answer the following objective: What are the differences with modelling a public transport network in Emme and in Visum, based on that the passengers only have information about the travel times and the line frequency, and why does the differences occur?

    In order to evaluate how the algorithms work in a larger network, Nacka municipality (in Stockholm) and the new metro route between Nacka Forum and Kungsträdgården have been used. The motivation for choosing this area and case is due to that it is interesting to see what differences could occur between the programs when there is a major change in the traffic network.

    The network of Nacka, and parts of Stockholm City, has been developed from an existing road network of Sweden and then restricted by "cutting out" the area of interest and then removing all public transportation lines outside the selected area. The OD-matrix was also limited and in order not to loose the correct flow of travellers portal zones was used to collect and retain volumes.

    To find out why the differences occur the headway-based algorithms in each software were studied carefully. An example of a small and simple network (consisting of only a start and end node) has been used to demonstrate and show how the algorithms work and why volumes split differently on the existing transit lines in Emme and Visum. The limited network of Nacka shows how the different software may produce different results in a larger public transport network.

    The results show that there are differences between the program algorithms but the significance varies depending on which output is being studied and the size of the network. The Visum algorithm results in more total boardings, i.e. more passengers have an optimal strategy including a transit. The algorithms are very similar in both software programs, since they include more or less parts of the optimal strategy. The parameters used are taken more or less into consideration in Emme and Visum. For example Visum will first of all focus on the shortest total travel time and then consider the other lines with respect to the maximum waiting time. Emme however, first focuses on the shortest travel time and then considers the total travel time for other lines with half the waiting time instead of the maximum wait time. This results in that less transit lines will be attractive in Emme compared to Visum. The thesis concludes that varying the parameters for public transport in each software algorithm one can obtain similar results, which implies that it is most important to choose the best parameter values and not to choose the "best" software when simulating a traffic network.

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  • 27.
    Schon, Thomas
    et al.
    Kalmar County Hospital.
    Labbe Sandelin, Lisa
    Kalmar County Hospital.
    Bonnedahl, Jonas
    Kalmar County Hospital.
    Hedeback, Fredrika
    Kalmar County Hospital.
    Wistedt, Annika
    Kalmar County Hospital.
    Brudin, Lars
    Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences.
    Jarnheimer, Per-Ake
    Kalmar County Hospital.
    A comparative study of three methods to evaluate an intervention to improve empirical antibiotic therapy for acute bacterial infections in hospitalized patients2011In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, ISSN 0036-5548, Vol. 43, no 4, p. 251-257Article in journal (Refereed)
    Abstract [en]

    Background: In order to limit the use of broad-spectrum antibiotics, standardized empirical therapy against acute bacterial infections has been advocated. Methods: Guidelines for acute bacterial infections recommending increased usage of benzylpenicillin and restricted use of fluoroquinolones and cephalosporins have been implemented in Kalmar County, Sweden. We evaluated this strategy by recording therapy in patients with bacteraemia, antibiotic requisition, and point prevalence surveys prior to this intervention and at 6 and 12 months after. Results: Comparing the methods simultaneously, there was good agreement between them and an overall significant change in antibiotic usage. There was a significant shift from cefuroxime to cefotaxime and a borderline significant increase in the use of benzylpenicillin (p == 0.057). Based on the defined daily dose (DDD), a highly significant decrease in total cefotaxime and cefuroxime usage was observed that was not detected when applying the prescribed daily dose (PDD), which is adapted to local treatment practices. No change was found in mortality in Staphylococcus aureus bacteraemia or the incidence of Clostridium difficile infection. Conclusions: We conclude that the implementation of the new guidelines has resulted in a significant change in antibiotic usage, which could be conveniently monitored by antibiotic requisition if PDD is used in addition to DDD.

  • 28.
    Winters, Andrew Ross
    et al.
    Mathematisches Institut, Universität zu Köln, Köln, Germany.
    Moura, Rodrigo C.
    Department of Aeronautics, Imperial College London, South Kensington Campus, London, United Kingdom / Depto. de Aerodinâmica, Instituto Tecnológico de Aeronáutica (ITA), Praça Mal. Eduardo Gomes, Brazil.
    Mengaldo, Gianmarco
    Division of Engineering and Applied Science, California Institute of Technology, Pasadena, USA.
    Gassner, Gregor J.
    Mathematisches Institut, Universität zu Köln, Köln, Germany.
    Walch, Stefanie
    I. Physikalisches Institut, Universität zu Köln, Köln, Germany.
    Peiro, Joaquim
    Department of Aeronautics, Imperial College London, South Kensington Campus, London, United Kingdom.
    Sherwin, Spencer J.
    Department of Aeronautics, Imperial College London, South Kensington Campus, London, United Kingdom.
    A comparative study on polynomial dealiasing and split form discontinuous Galerkin schemes for under-resolved turbulence computations2018In: Journal of Computational Physics, ISSN 0021-9991, E-ISSN 1090-2716, Vol. 372, p. 1-21Article in journal (Refereed)
    Abstract [en]

    This work focuses on the accuracy and stability of high-order nodal discontinuous Galerkin (DG) methods for under-resolved turbulence computations. In particular we consider the inviscid Taylor-Green vortex (TGV) flow to analyse the implicit large eddy simulation (iLES) capabilities of DG methods at very high Reynolds numbers. The governing equations are discretised in two ways in order to suppress aliasing errors introduced into the discrete variational forms due to the under-integration of non-linear terms. The first, more straightforward way relies on consistent/over-integration, where quadrature accuracy is improved by using a larger number of integration points, consistent with the degree of the non-linearities. The second strategy, originally applied in the high-order finite difference community, relies on a split (or skew-symmetric) form of the governing equations. Different split forms are available depending on how the variables in the non-linear terms are grouped. The desired split form is then built by averaging conservative and non-conservative forms of the governing equations, although conservativity of the DG scheme is fully preserved. A preliminary analysis based on Burgers’ turbulence in one spatial dimension is conducted and shows the potential of split forms in keeping the energy of higher-order polynomial modes close to the expected levels. This indicates that the favourable dealiasing properties observed from split-form approaches in more classical schemes seem to hold for DG. The remainder of the study considers a comprehensive set of (under-resolved) computations of the inviscid TGV flow and compares the accuracy and robustness of consistent/over-integration and split form discretisations based on the local Lax-Friedrichs and Roe-type Riemann solvers. Recent works showed that relevant split forms can stabilize higher-order inviscid TGV test cases otherwise unstable even with consistent integration. Here we show that stable high-order cases achievable with both strategies have comparable accuracy, further supporting the good dealiasing properties of split form DG. The higher-order cases achieved only with split form schemes also displayed all the main features expected from consistent/over-integration. Among test cases with the same number of degrees of freedom, best solution quality is obtained with Roe-type fluxes at moderately high orders (around sixth order). Solutions obtained with very high polynomial orders displayed spurious features attributed to a sharper dissipation in wavenumber space. Accuracy differences between the two dealiasing strategies considered were, however, observed for the low-order cases, which also yielded reduced solution quality compared to high-order results.

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    A comparative study on polynomial dealiasing and split form discontinuous Galerkin schemes for under-resolved turbulence computations
  • 29.
    Vallin, Olesya
    Linköping University, Department of Religion and Culture.
    A Complementary Developmental View on Morally Arbitrary Contingencies in Rawls’s Theory of Justice2007Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The paper explores theoretical shortcomings in the egalitarian theory by John Rawls and provides a complementary view on the problem of morally arbitrary contingencies. The conception of natural lottery, which Rawls presents to signify the starting range of morally arbitrary inequalities, falls short in philosophical grounding. According to critics, the notion of natural lottery appeals to the philosophical conception of moral luck which undermines ascription of moral responsibility. Since moral responsibility is a basic prerequisite for egalitarian justice, the appeal to morally arbitrary contingencies of the natural lottery may be self-defeating for the theory.

    Criticizing Rawls’s approach to morally arbitrary contingencies Susan Hurley investigates philosophical groundings for judgment of moral responsibility. Philosophical inquiries into moral luck differentiate four categories of luck and expose the difficulties of ascription of moral responsibility for it. The conception of moral luck implies epistemological shortcomings in the rational judgment of moral responsibility. Hurley claims that ascription of moral responsibility requires another logical strategy.

    The critical discussion by Norman Daniels refers to another egalitarian theory by Ronald Dworkin which suggests ascription of moral responsibility on a gradual scale. The theory divides the naturally contingent recourses into categories of brute luck and option luck. This strategy stratifies normative standards of responsibility by the criteria of individual choice and circumstances.

    Considering the strategy of gradual ascription of responsibility, I suggest to apply a moral developmental perspective as an additional outlook on the moral responsibility in egalitarian theory. The theory of moral development by Lawrence Kohlberg provides an explanation of a gradual development of moral responsibility through a natural order of developmental stages. It stratifies the moral responsibility into a hierarchical model of measurement and systematizes the order of normative standards.

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  • 30.
    Aziz, Mubashir
    et al.
    Islamia Univ Bahawalpur, Pakistan.
    Ejaz, Syeda Abida
    Islamia Univ Bahawalpur, Pakistan.
    Tamam, Nissren
    Princess Nourah Bint Abdulrahman Univ, Saudi Arabia.
    Siddique, Farhan
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. Royal Inst Med Sci RIMS, Pakistan.
    A comprehensive computational approach for the identification of structure-based potential pharmacological candidates as selective AKR1B1 and AKR1B10 inhibitors: repurposing of purine alkaloids for the treatment of cancer2023In: Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, E-ISSN 1538-0254, Vol. 41, no 16, p. 7892-7912Article in journal (Refereed)
    Abstract [en]

    Significant metabolic pathways have been linked to AKR1B1 and AKR1B10. These enzymes are crucial biological targets in the therapy of colon cancer. In the past several decades, drug repurposing has gained appeal as a time and cost-efficient strategy for providing new indications for existing drugs. The structural properties of the plant-based alkaloidal drugs theobromine and theophylline were examined using density functional theory (DFT) computations, where the B3LYP/SVP method was used to quantify the dipole moment, polarizability, and optimization energy. Optimized structures obtained through DFT studies were docked inside the active pocket of target proteins to evaluate their inhibitory potential. Moreover, molecular dynamic simulation provides significant insight into a dynamic view of molecular interactions. The findings of current revealed theobromine and theophylline as strong AKR1B1 and AKR1B10 inhibitors, respectively. In addition, the anti-cancer potential of theophylline and theobromine was validated by targeting various tumor proteins, i.e. NF-kappa B, cellular tumor antigen P53 and caspase-3 using a molecular docking approach. Theobromine was found to be strongly interacted with NF-kappa B and caspase-3, whereas theophylline potentially inhibited cellular tumor antigen P53. In addition, the ADMET characteristics of theobromine and theophylline were identified, confirming their drug-like capabilities. These results should open the way for further experimental validation and structure-based drug design/repurposing of AKR1B1/AKR1B10 inhibitors for the treatment of colon cancer and associated malignancies. Communicated by Ramaswamy H. Sarma

  • 31.
    Hughes, B. P.
    et al.
    Curtin University, Australia.
    Anund, Anna
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Swedish Rd and Transport Research Institute, S-58195 Linkoping, Sweden.
    Falkmer, Torbjörn
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Curtin University, Australia; La Trobe University, Australia.
    A comprehensive conceptual framework for road safety strategies2016In: Accident Analysis and Prevention, ISSN 0001-4575, E-ISSN 1879-2057, Vol. 90, p. 13-28Article in journal (Refereed)
    Abstract [en]

    Road safety strategies (generally called Strategic Highway Safety Plans in the USA) provide essential guidance for actions to improve road safety, but often lack a conceptual framework that is comprehensive, systems theory based, and underpinned by evidence from research and practice. This paper aims to incorporate all components, policy tools by which they are changed, and the general interactions between them. A framework of nine mutually interacting components that contribute to crashes and ten generic policy tools which can be applied to reduce the outcomes of these crashes was developed and used to assess 58 road safety strategies from 22 countries across 15 years. The work identifies the policy tools that are most and least widely applied to components, highlighting the potential for improvements to any individual road safety strategy, and the potential strengths and weaknesses of road safety strategies in general. The framework also provides guidance for the development of new road safety strategies, identifying potential consequences of policy tool based measures with regard to exposure and risk, useful for both mobility and safety objectives. (C) 2016 Elsevier Ltd. All rights reserved.

  • 32.
    Kylhammar, David
    et al.
    Department of Clinical Sciences Lund, Cardiology, Lund University, The Section for Heart Failure and Valvular Disease, Heart and Lung Medicine, Skåne University Hospital, Lund, Sweden.
    Kjellström, Barbro
    Cardiology Unit, Department of Medicine Solna, Karolinska Institutet, Sweden..
    Hjalmarsson, Clara
    University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden..
    Jansson, Kjell
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
    Nisell, Magnus
    Department of Medicine Solna, Karolinska Institute, and The Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden..
    Söderberg, Stefan
    Department of Public Health and Clinical Medicine, Heart Centre, Umeå University, Umeå, Sweden.
    Wikström, Gerhard
    Department of Medical Sciences, Cardiology, Uppsala University, and Uppsala Academic Hospital, Uppsala, Sweden..
    Rådegran, Göran
    Department of Clinical Sciences Lund, Cardiology, Lund University, and The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Skåne University Hospital, Lund, Sweden.
    A comprehensive risk stratification at early follow-up determines prognosis in pulmonary arterial hypertension.2018In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, no 47, p. 4175-4181Article in journal (Refereed)
    Abstract [en]

    Aims: Guidelines recommend a goal-oriented treatment approach in pulmonary arterial hypertension (PAH). The aim is to reach a low-risk profile, as determined by a risk assessment instrument. This strategy is incompletely validated. We aimed to investigate the bearing of such risk assessment and the benefit of reaching a low-risk profile.

    Methods and results: Five hundred and thirty PAH patients were included. Follow-up assessments performed after a median of 4 (interquartile range 3-5) months were available for 383 subjects. Patients were classified as 'Low', 'Intermediate', or 'High risk' and the benefit of reaching the 'Low risk' group was estimated. Survival differed (P < 0.001) between the risk groups at baseline and at follow-up. Survival was similar for patients who remained in or improved to the 'Low risk' group. Survival was similar for patients who remained in or worsened to the 'Intermediate risk' or 'High risk' groups. Irrespective of follow-up risk group, survival was better (P < 0.001) for patients with a higher proportion of variables at low risk. Results were unchanged after excluding patients with idiopathic PAH >65 years at diagnosis, and when patients with idiopathic or connective tissue disease-associated PAH were analysed separately. Patients in the 'Low risk' group at follow-up exhibited a reduced mortality risk (hazard ratio 0.2, 95% confidence interval 0.1-0.4 in multivariable analysis adjusted for age, sex and PAH subset), as compared to patients in the 'Intermediate risk' or 'High risk' groups.

    Conclusion: These findings suggest that comprehensive risk assessments and the aim of reaching a low-risk profile are valid in PAH.

  • 33.
    Hjalmarson, Emil
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    A computer-aided approach to design of robust analog circuits2006Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Traditional design methods for analog circuits are based on rules-of-thumbs, experience, and trial-and-error approaches involving the use of circuit simulators. It is an unstructured process, which is time-consuming, error prone, and requires the attention of a skilled analog designer. This situation calls for design methodologies that are more efficient.

    We have developed an efficient approach and corresponding tools that address these issues. A computer-aided design tool for design of large analog circuits with low level of human intervention has been developed. The tool combines efficient performance measure evaluation and optimization methods to determine the device sizes and generate layouts for analog circuits. Large analog circuits with about 200 devices have been designed. The circuits are optimized with respect to, e.g., power consumption, and subject to a large number of performance requirements. All performance measures are automatically derived, which reduces the probability of introducing errors.

    Experimental results indicate that our approach can be used to design robust high-performance analog circuits with improved performance compared to manual approaches. Furthermore, the computer-aided tool decreases both the overall design time and the time required of a skilled designer.

    To accomplish this, an optimization strategy that enables device sizing without an initial design has been developed. Robust circuits are obtained by taking the variations in the manufacturing process into account. Degrading layout effects are also considered using a parasitic feedback technique. To gain insight and allow exploration of the complex relation between performance measures in analog circuits, we have developed techniques for design space exploration.

  • 34.
    Gunnarsson, Fredrik
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Blom, Jonas
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Concept of Power Control in Cellular Radio Systems1999In: Proceedings of the 14th World Congress, 1999Conference paper (Refereed)
    Abstract [en]

    Due to the rapid expansion of the cellular radio systems market, and the need for wireless multimedia services, the available resources have to be utilized efficently. A common strategy is to control the transmitter powers of the mobiles and base stations. However, when applying power control to real systems, a number of challenges are prevalent. The performance is limited by time delays, nonlinearities and the availability of measurements and adequate quality measures. In this paper we present a Power Regulator concept, which comprises an Unknown Input Observer, a Quality Mapper and a Power Control Algorithm. The applicability of the concept is exemplified using frequency hopping GSM, and simulations indicate benefits of employing the proposed concept.

  • 35.
    Gunnarsson, Fredrik
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Blom, Jonas
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Concept of Power Control in Cellular Radio Systems1999Report (Other academic)
    Abstract [en]

    Due to the rapid expansion of the cellular radio systems market, and the need for wireless multimedia services, the available resources have to be utilized efficently. A common strategy is to control the transmitter powers of the mobiles and base stations. However, when applying power control to real systems, a number of challenges are prevalent. The performance is limited by time delays, nonlinearities and the availability of measurements and adequate quality measures. In this paper we present a Power Regulator concept, which comprises an Unknown Input Observer, a Quality Mapper and a Power Control Algorithm. The applicability of the concept is exemplified using frequency hopping GSM, and simulations indicate benefits of employing the proposed concept.

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    A Concept of Power Control in Cellular Radio Systems
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  • 36.
    Banerjee, Antara
    et al.
    Chettinad Hosp & Res Inst CHRI, India.
    Deka, Dikshita
    Chettinad Hosp & Res Inst CHRI, India.
    Muralikumar, Makalakshmi
    Chettinad Hosp & Res Inst CHRI, India.
    Sun-Zhang, Alexander
    Karolinska Inst, Sweden.
    Bisgin, Atil
    Cukurova Technopolis, Turkey; Cukurova Univ, Turkey.
    Christopher, Cynthia
    Chettinad Hosp & Res Inst CHRI, India.
    Zhang, Hong
    Orebro Univ, Sweden.
    Sun, Xiao-Feng
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Pathak, Surajit
    Chettinad Hosp & Res Inst CHRI, India.
    A concise review on miRNAs as regulators of colon cancer stem cells and associated signalling pathways2023In: Clinical and Translational Oncology, ISSN 1699-048X, E-ISSN 1699-3055, Vol. 25, p. 3345-3356Article, review/survey (Refereed)
    Abstract [en]

    Despite recent therapy advances and a better understanding of colon cancer biology, it remains one of the major causes of death. The cancer stem cells, associated with the progression, metastasis, and recurrence of colon cancer, play a major role in promoting the development of tumour and are found to be chemo resistant. The stroma of the tumour, which makes up the bulk of the tumour mass, is composed of the tumour microenvironment. With the advent of theranostic and the development of personalised medicine, miRNAs are becoming increasingly important in the context of colon malignancies. A holistic understanding of the regulatory roles of miRNAs in cancer cells and cancer stem cells will allow us to design effective strategies to regulate miRNAs, which could lead to improved clinical translation and creating a potent colon cancer treatment strategy. In this review paper, we briefly discuss the history of miRNA as well as the mechanisms of miRNA and cancer stem cells that contribute to the tumour growth, apoptosis, and advancement of colon cancer. The usefulness of miRNA in colorectal cancer theranostic is further concisely reviewed. We conclude by holding a stance in addressing the prospects and possibilities for miRNA by the disclosure of recent theranostic approaches aimed at eradicating cancer stem cells and enhancing overall cancer treatment outcomes.

  • 37.
    Fejes, Andreas
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Education and Adult Learning. Linköping University, Faculty of Educational Sciences.
    Nicoll, Katherine
    University of Stirling.
    A confessing 'science' in education and lifelong learning2013Conference paper (Refereed)
    Abstract [en]

    In this paper we identify resources drawn on from Foucault that are distinctive and pertinent for specific forms of analyses of what is happening in the turn to confessional practices in education and lifelong learning. We identify that confessional practices have come to shape and govern the Western world; they have emerged across the practices of the human sciences and are now intrinsic to our everyday lives and understandings of ourselves. Education and learning have a key position in promulgating confessional practices as a new social norm. They are key as perpetrators of this new kind fashioning of ourselves as human kinds in a particular way.

     

    We describe a regime and apparatus of power of education and lifelong learning which has confession intrinsic to its maintenance and productive force. Confession is described as technology, conduit of power, operating one person in relation to another, and dominating today in the production of specific forms of confessing people.  We call this ‘strategy’. Within this regime, in education and policy circles and more widely, we identify a shift in the talk accompanying and surrounding the emergence of these techniques: whereas before educators and policy makers talked about education, they now talk of learning. Lifelong learning and the learning society, the knowledge economy, society and Knowledge Age are themes that have come to dominate the texts emanating from the cloistered grounds of governmental offices and intra-national agencies. The question remains therefore of where this strategy takes us in terms of its wider social and political effects in western societies.

    The paper identifies and explores other previous educational and lifelong learning research that has considered confessional practices to consider whether or not these find answers to the question of what is happening today'

  • 38.
    Blikstad, Mathias
    et al.
    Saab AB, Sweden.
    Karlsson, Emil
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    Lööw, Tomas
    Saab AB, Sweden.
    Rönnberg, Elina
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    A constraint generation procedure for pre-runtime scheduling of integrated modular avionic systems2017In: Proceedings of the 13th Workshop on Models and Algorithms for Planning and Scheduling Problems / [ed] Susanne Albers, Nicole Megow, Andreas S. Schulz, Leen Stougie, 2017Conference paper (Other academic)
    Abstract [en]

    In modern integrated modular avionic systems, applications share hardware resources on a common avionic platform. Such an architecture necessitates strict requirements on the spatial and temporal partitioning of the system to prevent fault propagation between different aircraft functions. One way to establish a temporal partitioning is through pre-runtime scheduling of the system, which involves creating a schedule for both tasks and a communication network.

    While the avionic systems are growing more and more complex, so is the challenge of scheduling them. Scheduling of the system has an important role in the development of new avionic systems since functionality typically is added to the system over a period of several years and a scheduling tool is used both to detect if the platform can host the new functionality and, in case this is possible, to create a new schedule. For this reason an exact solution strategy for avionics scheduling is preferred over a heuristic one.

    In this paper we present a mathematical model for an industrially relevant avionic system and present a constraint generation  procedure for scheduling of such systems. We apply our optimisation approach to instances provided by our industrial partner. These instances are of relevance for the development of future avionic systems and contain up to 20 000 tasks to be scheduled. The computational results show that our optimisation approach can be used to create schedules for such instances within reasonable time.

  • 39.
    Karlsson, Kristoffer
    et al.
    Linköping University, Department of Management and Engineering, Information Systems. Linköping University, Faculty of Arts and Sciences.
    Spyrou, Nikolas Karl
    Linköping University, Department of Management and Engineering, Information Systems. Linköping University, Faculty of Arts and Sciences.
    A consultant perspective on Digital transformation: Experiences of successful digitalization2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Progress in digital technologies has influenced organizations and individuals alike. The focus of organizations has been to adapt to the dynamic digital landscapes; ranging from expanding the boundaries of existing markets, to conquer unexplored and unclaimed opportunities. These include collaboration in novel partnerships with external actors, creating additional value through alternative use of existing technologies and services, provided to the customer in the growing digitally interconnected ecosystem.

    The purpose of this work is to explore contemporary consultant’s experiences related to the digitalization of their client organizations. Which major factors, in their experience, increase the success rate of digitalization or digital transformation projects, and which factors form the greatest risks?

    In order to answer the research questions and thereby fulfill the purpose, a case study was performed, where eleven semi-structured interviews were conducted with consultants from two firms. A thematic analysis was conducted, and the results were presented in the more general topics Perspectives on change, Change management, User involvement, Digital maturity, and Cultural aspects.

    These adaptations made by organizations need to be aligned with the overarching goals and values they may hold. In order for such an investment to stand a chance of being successful, support is needed from all levels of the organization. Both through the willingness to adapt, and suitability of the proposed investment. In order to provide support is through proper change management, with a specific focus on the human side of the planned change. If the implemented system or process is not being used, or not utilized as intended, the generated improvement will be less than expected. The digital strategy was argued to be of less use to the organization the less connected it was to the general strategic perspectives. The digital aspects described in such a document must be incorporated in the identity and culture of the organization to remain useful, they need to become part of their DNA.

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  • 40.
    Sciarretta, A.
    et al.
    IFP Energies Nouvelles, France .
    Serrao, L.
    Dana Corporation, Italy.
    Dewangan, P.C.
    IFP Energies Nouvelles, France; IFP School, France .
    Tona, P.
    IFP Energies Nouvelles, France .
    Bergshoeff, E.N. D.
    TU Eindhoven, Netherlands.
    Bordons, C.
    University of Seville, Spain .
    Charmpa, L.
    IFP Sch, France Continental, France .
    Elbert, Ph.
    ETH Zurich, Switzerland.
    Eriksson, Lars
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Hofman, T.
    TU Eindhoven, Netherlands .
    Hubacher, M.
    TU Eindhoven, Netherlands .
    Isenegger, R.
    TU Eindhoven, Netherlands .
    Lacandia, F.
    Ohio State University, USA.
    Laveau, A.
    IFP School, France.
    Li, H.
    IFP School, France.
    Marcos, D.
    University of Seville, Spain .
    Nueesch, T.
    ETH Zurich, Switzerland.
    Onori, S.
    Ohio State University, USA .
    Pisu, P.
    Clemson University, USA .
    Rios, J.
    Clemson University, USA .
    Silvas, E.
    TU Eindhoven, Netherlands .
    Sivertsson, Martin
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Tribioli, L.
    Ohio State University, USA .
    van der Hoeven, A.-J.
    TU Eindhoven, Netherlands .
    Wu, M.
    IFP School, France.
    A control benchmark on the energy management of a plug-in hybrid electric vehicle2014In: Control Engineering Practice, ISSN 0967-0661, E-ISSN 1873-6939, Vol. 29, p. 287-298Article in journal (Refereed)
    Abstract [en]

    A benchmark control problem was developed for a special session of the IFAC Workshop on Engine and Powertrain Control, Simulation and Modeling (E-COSM 12), held in Rueil-Malmaison, France, in October 2012. The online energy management of a plug-in hybrid-electric vehicle was to be developed by the benchmark participants. The simulator, provided by the benchmark organizers, implements a model of the GM Voltec powertrain. Each solution was evaluated according to several metrics, comprising of energy and fuel economy on two driving profiles unknown to the participants, acceleration and braking performance, computational performance. The nine solutions received are analyzed in terms of the control technique adopted (heuristic rule-based energy management vs. equivalent consumption minimization strategies, ECMS), battery discharge strategy (charge depleting-charge sustaining vs. blended mode), ECMS implementation (vector-based vs. map-based), ways to improve the implementation and improve the computational performance. The solution having achieved the best combined score is compared with a global optimal solution calculated offline using the Pontryagins minimum principle-derived optimization tool HOT.

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  • 41.
    Bengtsson, Mikael
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, Faculty of Science & Engineering.
    A Control-Oriented 0D Model of a Turbocharger Gas Stand Including Heat Transfer2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    A turbocharger’s performance is measured in a gas stand in order to provide information of the components characteristics. The measurement procedure is a very time consuming process and it is thus desired to make it more time-efficient.

    To allow for development of an enhanced control strategy used during the measurements, a 0D model of a gas stand is developed. The physical gas stand components are modeled and validated against measurements, all showing a reasonable result. Turbocharger heat transfers are investigated and modeled using a lumped capacitance approach. The heat transfer models shows approximative results when comparing with measurements which is explained by the lack of temperature measurement made on the bearing housing.

    When the complete gas stand model is validated against measurements, an improvement of the measurement procedure is examined. By adding an idealized heat source with the possibility to heat the compressor housing, it is possible to reduce the time it takes to reach an equilibrium when switching between two steady state operating points. 

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  • 42.
    Thöresson, Sanna
    Linköping University, Department of Thematic Studies, The Department of Gender Studies.
    A Critical Discourse Analysis of Non-violent Direct Action within This Is Not A Drill: An Extinction Rebellion Handbook2020Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates the portrayal of non-violent direct action (NVDA) in This Is Not a Drill: An Extinction Rebellion Handbook by considering the two chapters “Courting Arrest” by Jay Griffiths, and “The Civil Resistance Model” by Roger Hallam. Using critical discourse analysis in the style of Norman Fairclough, I examine the textual features, discourse practices, and social practices of the chapters by applying theories of environmental justice, intersectionality, and embodiment. I argue that Griffiths and Hallam reproduce oppressive power structures by excluding certain identities and experiences from their discourse. First, the lack of a discussion of the situatedness of violence within the NVDA strategy employed by Extinction Rebellion – focusing on having as many protestors arrested as possible – represents the acts of arrest as inherently non-violent. This representation erases other possible experiences of arrest from the discourse. Second, the authors portray their own experiences as universal, and thereby create a universal subject that is white, middle-class, able-bodied, and a legal resident of the UK. Discourse is seen as both constitutive of, and constituted by, the social world; this portrayal of subjectivities is shown to have very real effects on to what degree certain identities feel at home within the Extinction Rebellion movement. I conclude the study with a discussion of possible paths for Extinction Rebellion and other similar movements to become more inclusive by adopting a more intersectional perspective that acknowledges the embodied realities of different identities. By applying this perspective, these movements can start working against hegemonic structures of oppression that exclude certain (non-white) identities from decision-making processes.

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  • 43.
    Lazarus, J.V.
    et al.
    Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Spain.
    Ekstedt, Mattias
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Mag- tarmmedicinska kliniken.
    Marchesini, G.
    Department of Medical and Surgical Sciences, “Alma Mater” University, Bologna, Italy.
    Mullen, J.
    EASL International Liver Foundation, Geneva, Switzerland.
    Novak, K.
    University Medical Center Ljubljana, Dept. of Gastroenterology, Slovenia.
    Pericàs, J.M.
    Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Spain; Translational Research Group on Infectious Diseases of Lleida (TRIDLE), Infectious Diseases Clinical Direction, Biomedical Research Institute Dr Pifarré, University of Lleida, Lleida, Spain.
    Roel, E.
    Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Spain; Preventive Medicine and Epidemiology, Hospital Clínic, Barcelona, Spain.
    Romero-Gómez, M.
    UCM Digestive Diseases, ciberehd and IBIS, Virgen del Rocío University Hospital, University of Seville, Seville, Spain.
    Ratziu, V.
    Pitie-Salpetriere Hospital, Department of Hepatology University, Paris 6, France.
    Tacke, F.
    Department of Hepatology/Gastroenterology, Charité University Medical Center, Berlin, Germany.
    Cortez-Pinto, H.
    Departamento de Gastrenterologia, CHLN, Clínica Universitária de Gastrenterologia, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Portugal.
    Anstee, Q.M.
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; The Liver Unit and NIHR Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
    EASL, International Liver Foundation NAFLD Policy Review Collaborators
    A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe2020In: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 72, no 1, p. 14-24Article in journal (Refereed)
    Abstract [en]

    Background & Aims

    Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become an important field of biomedical inquiry. We aimed to determine whether European countries have mounted an adequate public health response to NAFLD and non-alcoholic steatohepatitis (NASH).

    Methods

    In 2018 and 2019, NAFLD experts in 29 European countries completed an English-language survey on policies, guidelines, awareness, monitoring, diagnosis and clinical assessment in their country. The data were compiled, quality checked against existing official documents and reported descriptively.

    Results

    None of the 29 participating countries had written strategies or action plans for NAFLD. Two countries (7%) had mentions of NAFLD or NASH in related existing strategies (obesity and alcohol). Ten (34%) reported having national clinical guidelines specifically addressing NAFLD and, upon diagnosis, all included recommendations for the assessment of diabetes and liver cirrhosis. Eleven countries (38%) recommended screening for NAFLD in all patients with either diabetes, obesity and/or metabolic syndrome. Five countries (17%) had referral algorithms for follow-up and specialist referral in primary care, and 7 (24%) reported structured lifestyle programmes aimed at NAFLD. Seven (24%) had funded awareness campaigns that specifically included prevention of liver disease. Four countries (14%) reported having civil society groups which address NAFLD and 3 countries (10%) had national registries that include NAFLD.

    Conclusions

    We found that a comprehensive public health response to NAFLD is lacking in the surveyed European countries. This includes policy in the form of a strategy, clinical guidelines, awareness campaigns, civil society involvement, and health systems organisation, including registries.

    Lay summary

    We conducted a survey on non-alcoholic fatty liver disease with experts in European countries, coupled with data extracted from official documents on policies, clinical guidelines, awareness, and monitoring. We found a general lack of national policies, awareness campaigns and civil society involvement, and few epidemiological registries.

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  • 44.
    Papageorgiou, Athanasios
    et al.
    Linköping University, Department of Management and Engineering, Machine Design. Linköping University, Faculty of Science & Engineering.
    Ölvander, Johan
    Linköping University, Department of Management and Engineering, Machine Design. Linköping University, Faculty of Science & Engineering.
    A Data Management and Visualization Tool for Integrating Optimization Results in Product Development2018In: DS 91: Proceedings of NordDesign 2018, Linköping, Sweden, 14th - 17th August 2018: DESIGN IN THE ERA OF DIGITALIZATION / [ed] Ekströmer, Philip; Schütte, Simon and Ölvander, Johan, 2018Conference paper (Other academic)
    Abstract [en]

    This paper presents a data management and visualization tool that was developed in parallel with a Multidisciplinary Design Optimization (MDO) framework in order to enable a more effective use of the obtained results within the Product Development Process (PDP). To this date, the main problem is that the majority of MDO case studies conclude by suggesting a small number of optimal configurations, which do not really hold any meaningful value for the decision makers since they represent only a narrow area of the design space. In this light, the proposed tool aims to provide designers with new possibilities in respect to post-processing of large data sets, and subsequently, to allow the non-technical teams to be engaged and benefit from the use of MDO in the company practices. As an example, an Unmanned Aerial Vehicle (UAV) configurator developed by using the Graphical User Interface (GUI) of MATLAB is herein presented, and it is shown that a tool for handling the results can be the logical next step towards integrating MDO in the manufacturing industry. Overall, this work aims to demonstrate the benefits of the present visualization and management tool as a complementary addition to an existing optimization framework, and also to determine if this approach can be the right strategy towards improving the MDO method for an eventual use in the PDP of complex pro-ducts like UAVs.

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  • 45.
    Dolphin, Gunnar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    A designed branched three-helix bundle protein dimer2006In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 128, no 22, p. 7287-7290Article in journal (Refereed)
    Abstract [en]

    The ultimate goals of de novo protein design are the construction of novel tertiary structures and functions. Here is presented the design and synthesis of a uniquely branched three-helix bundle that folds into a well-folded dimeric protein. The branching of this protein was performed by the method of native chemical ligation, which provides a chemoselective and stable amide bond between the unprotected fragments. This ligation strategy was possible by the presented facile preparation of a peptide (43 amino acids) with a specific side chain thioester, which is synthesized by general Fmoc solid phase peptide synthesis. From the presented structural analysis, it is seen that the folded protein is present as a stable and highly helical dimer, thus forming a six-helix bundle. This unique tertiary structure, composed of a dimer of three individual a-helices branched together, offers different possibilities for protein engineering, such as metal and cofactor binding sites, as well as for the construction of novel functions. © 2006 American Chemical Society.

  • 46.
    Chen, Zhongsheng
    et al.
    Tongji Univ, Peoples R China.
    Zhang, Ying
    Tongji Univ, Peoples R China.
    Peng, Zebo
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Jiang, Jianhui
    Tongji Univ, Peoples R China.
    A Deterministic-Path Routing Algorithm for Tolerating Many Faults on Wafer-Level NoC2019In: 2019 DESIGN, AUTOMATION and TEST IN EUROPE CONFERENCE and EXHIBITION (DATE), IEEE , 2019, p. 1337-1342Conference paper (Refereed)
    Abstract [en]

    Wafer-level NoC has emerged as a promising fabric to further improve supercomputer performance, but this new fabric may suffer from the many-fault problem. This paper presents a deterministic-path routing algorithm for tolerating many faults on wafer-level NoCs. The proposed algorithm generates routing tables using a breadth-first traversal strategy, and stores one routing table in each NoC switch. The switch will then transmit packages according to its routing table online. We use the Tarjan algorithm to dynamically reconfigure the routes to avoid the faulty nodes and develop the deprecated link/node rules to ensure deadlock-free communication of the NoCs. Experimental results demonstrate that the proposed algorithm does not only tolerate the effects of many faults, but also maximizes the available nodes in the reconfigured NoC. The performance of the proposed algorithm in terms of average latency, throughput, and energy consumption is also better than those of the existing solutions.

  • 47.
    Taxén, Lars
    Linköping University, Department of Computer and Information Science, Human-Centered systems. Linköping University, Faculty of Science & Engineering.
    A dialectical approach for transcending structuralism2024In: Signs in Activities: New Directions for Integrational Linguistics / [ed] D. Duncker, A. Pablé, London: Routledge , 2024, p. 81-105Chapter in book (Refereed)
    Abstract [en]

    The purpose of this contribution is to explore how a dialectical approach may further Integrational Linguistics into transcending structuralism. The strategy employed is to articulate the biomechanical and macrosocial factors in the communicational infrastructure as neurobiological attractors and social anchors respectively. Hence, the inquiry focuses on the dialectical relation between an individual’s neurobiological structure and her ability to confer signhood onto activity-relevant phenomena in the social environment. This makes it possible to conceive new directions for Integrational Linguistics by rethinking central aspects such as contextuality, indeterminacy, cotemporality, integration, and coordination. Conjectural as these directions may be, I put forward that the dialectical approach provides a promising launchpad for further inquiries into transcending structuralism and beyond.

  • 48.
    Li, Cheng
    et al.
    Chinese Acad Sci, Peoples R China.
    Wang, Chao
    Chinese Acad Sci, Peoples R China; Hebei Univ, Peoples R China.
    Guo, Yiting
    Chinese Acad Sci, Peoples R China.
    Jin, Yingzhi
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Yao, Nannan
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Wu, Yonggang
    Hebei Univ, Peoples R China.
    Zhang, Fengling
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Li, Weiwei
    Chinese Acad Sci, Peoples R China; Beijing Univ Chem Technol, Peoples R China.
    A diketopyrrolopyrrole-based macrocyclic conjugated molecule for organic electronics2019In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 7, no 13, p. 3802-3810Article in journal (Refereed)
    Abstract [en]

    In this work, the first diketopyrrolopyrrole (DPP) based donor-acceptor macrocyclic conjugated molecule was developed and its application in organic electronics was systematically studied. Macrocyclic molecules, as a fragment of armchair carbon nanotubes, have emerged as functional materials in materials chemistry, but the materials are always limited to cycloparaphenylenes. Using the donor-acceptor design strategy that has been widely used in high performance conjugated polymers for macrocyclic molecules, it will significantly broaden their species with tunable optical and electrical properties. Herein, we synthesize a well-defined macrocyclic molecule containing four electron-deficient DPP units alternating with electron-rich thiophenes. The new molecule was found to show high solubility, near-infrared absorption spectra and 3D charge transport properties. The new macrocyclic molecule as an electron acceptor was applied to non-fullerene organic solar cells, exhibiting an initial efficiency of 0.49%, while the linear molecule with a similar backbone only showed a very low efficiency of 0.03%. Our results demonstrate that donor-acceptor macrocyclic conjugated materials have great potential application in organic electronics.

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  • 49.
    Xu, Jin Wei
    et al.
    Bioinformatics Research Group School of Engineering and Information Technology The University of New South Wales Canberra, ACT 2600, Australia .
    Pham, Tuan D.
    Bioinformatics Research Group School of Engineering and Information Technology The University of New South Wales Canberra, Australia .
    Zhou, Xiaobo
    The Methodist Hospital Research Institute Cornell University Houston, TX 77030, USA.
    A double thresholding method for cancer stem cell detection2011Conference paper (Refereed)
    Abstract [en]

    Image analysis of cancer cells is important for cancer diagnosis and therapy, because it recognized as the most efficient and effective way to observe its proliferation. For the purpose of adaptive and accurate cancer cell image segmentation, a double threshold segmentation method is proposed in this paper. Based on a single gray-value histogram of the RGB color space, a double threshold, the key parameters of threshold segmentation can be fixed by a fitted-curve of the RGB component histogram. As reasonable thresholds confirmed, binary segmentation dependent on two thresholds, will be put into practice and result in binary image. With the post-processing of mathematical morphology and division of whole image, the better segmentation result can be finally achieved. By the comparison with other advanced segmentation methods such as level set and active contour, the proposed double thresholding has been found as the simplest strategy with shortest processing time as well as highest accuracy. The proposed method can be effectively used in the detection and recognition of cancer stem cells in images.

  • 50.
    Lindmark, Gustav
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    Altafini, Claudio
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    A driver node selection strategy for minimizing the control energy in complex networks2017In: IFAC PAPERSONLINE, ELSEVIER SCIENCE BV , 2017, Vol. 50, no 1, p. 8309-8314Conference paper (Refereed)
    Abstract [en]

    \This paper deals with the problem of controlling linear complex networks in an efficient way, i.e., with limited control energy. A general principle is provided, based on the eigenvalues of the network. It is shown numerically that the cost of controlling a network grows with the (absolute value of the) real part of the eigenvalues of the adjacency matrix. Constructive rules for driver node selection are also provided, based on the (weighted) topology of the network. In particular, we show that the key to have an energetically efficient driver node placement strategy is to use the skewness of the outdegree versus indegree distributions of the network, a topological property not associated before to controllability. (C) 2017, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

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