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  • 101.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimeli, Adriano
    Università degli Studi di Roma Tor Vergata.
    Di Natale, Corrado
    Dipartiment di Ingegneria Elettronica Università degli Studi di Roma Tor Vergata.
    Paolesse, Roberto
    Università degli Studi di Roma Tor Vergata.
    DAmico, Arnaldo
    Università degli Studi di Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical Sensing with Familiar Devices2006In: Angewandte Chemie : : a journal of the Gesellschaft Deutscher Chemiker.. International edition, Vol. 45, no 23, p. 3800-3803Article in journal (Refereed)
  • 102.
    Filippini, Daniel
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Andersson, Tony
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Svensson, Samuel
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, Faculty of Health Sciences.
    Microplate based biosensing with a computer screen aided technique2003In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 19, no 1, p. 35-41Article in journal (Refereed)
    Abstract [en]

    Melanophores, dark pigment cells from the frog Xenopus laevis, have the ability to change light absorbance upon stimulation by different biological agents. Hormone exposure (e.g. melatonin or α-melanocyte stimulating hormone) has been used here as a reversible stimulus to test a new compact microplate reading platform. As an application, the detection of the asthma drug formoterol in blood plasma samples is demonstrated. The present system utilizes a computer screen as a (programmable) large area light source, and a standard web camera as recording media enabling even kinetic microplate reading with a versatile and broadly available platform, which suffices to evaluate numerous bioassays. Especially in the context of point of care testing or self testing applications these possibilities become advantageous compared with highly dedicated comparatively expensive commercial systems.

  • 103.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Fingerprinting of fluorescence substances for diagnostic purposes using computer screen illumination2004In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 106, p. 302-310Article in journal (Refereed)
  • 104.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Bakker, Jimmy
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Optics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Fingerprinting of fluorescent substances for diagnostic purposes using computer screen illumination2005In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 106, p. 302-310Article in journal (Refereed)
  • 105.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Comina, G.
    Thin Films Laboratory, Science Faculty, Universidad Nacional De Ingenieria, Lima 31, Peru.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-assisted reflectance fingerprinting2005In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 107, no 2, p. 580-586Article in journal (Refereed)
    Abstract [en]

    The characterization of opaque color samples using reflected light is demonstrated with a computer screen photo-assisted technique (CSPT). CSPT utilizes standard computer screens as light sources and conventional web cameras as detectors to perform colorimetric or fluorescent evaluations that retain key spectral features of the tested substances. In this work, the fingerprinting of samples spectral reflectances is achieved by evaluating the reflected light under controlled computer screen illumination. Two different methods for processing of features are investigated, revealing complementary properties for classifications purposes. The attainable classification enables to distinguish different colors from just hues of a same color. © 2004 Elsevier B.V. All rights reserved.

  • 106.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Comina, G.
    Thin Films Laboratory Universidad National de Ingenieria, Lima, Peru.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Computer screen photo-assisted reflectance fingerprinting2004In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 107, p. 580-586Article in journal (Refereed)
  • 107.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, C.
    Paolese, R.
    Alimelli, A.
    DAmico, A.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Home and global (bio) chemical sensing with computer screen photo-assisted techniques2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Konferensbidrag (muntligt) på 11th World congress on internet in medicine - Mednet 2006, Toronto, Canada, 14-19 okt.

  • 108.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, C
    Paolesse, R
    D´Amico, A.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Distributed chemical monitoring for safety and security with computer screen photo-assissted techniques2007In: Safety and Security in Europe 2007,2007, 2007Conference paper (Refereed)
  • 109.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Di Natale, Corrado
    University of Rome, Italy.
    Paolesse, R
    Univresity of Rome, Italy.
    D´Amico, A.
    University of Rome, Italy.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-assisted techniques for global monitoring of environmental and sanitary parameters2007In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 121, no 1, p. 93-102Article in journal (Refereed)
    Abstract [en]

    The computer screen photo-assisted technique (CSPT) is a measuring method that uses regular computer screens as controlled light sources and web cameras as imaging detectors for optical evaluations of sensing substances, which optical properties respond to target analytes. The fact, that CSPT uses a globally distributed and familiar infrastructure as instrumentation and that is able to serve multiple targets with the same setup, makes it an attractive candidate for home testing. This article reviews the CSPT concept and focuses in two recent studies that demonstrate thorough CSPT determinations using a handy and eventually disposable assay format, with the potential to be as ubiquitous as the CSPT platforms themselves. The implications of such combination of technologies is discussed, and its potential to support the global monitoring of environmental and sanitary parameters, using Internet geography browsers, is analyzed. © 2006 Elsevier B.V. All rights reserved.

  • 110.
    Filippini, Daniel
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Gatto, Emanuela
    University Roma Tor Vergata.
    Alimelli, Adriano
    University Roma Tor Vergata.
    Ali Malik, Muhammad
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Di Natale, Corrado
    University Roma Tor Vergata.
    Paolesse, Roberto
    University Roma Tor Vergata.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Spectral fingerprinting of porphyrins for distributed chemical sensing2009In: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, ISSN 1088-4246, Vol. 13, no 1, p. 77-83Article in journal (Refereed)
    Abstract [en]

    Recent progress in spectral fingerprinting of fluorescent indicators using distributed instrumentation based on consumer electronic devices is reviewed. In particular, the evaluation of disposable assays using a computer screen photo-assisted technique (CSPT) is discussed. Sample identification and optimization strategies are analyzed as well as the underlying theoretical background for polychromatic spectral fingerprinting.

  • 111.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Gunnarsson, J.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical image generation with a grid-gate device2004In: Journal of Applied Physics, ISSN 0021-8979, E-ISSN 1089-7550, Vol. 96, no 12, p. 7583-7590Article in journal (Refereed)
    Abstract [en]

    Scanning light pulse technique generating distinctive chemical images of diverse gases is demonstrated using a sensing arrangement that allows unrestricted choice of sensing materials, disregarding its conductivity or morphology. The present device, a metal oxide semiconductor structure, disentangles biasing from chemical functions by providing an inert grid as a gate that supplies the proper biasing, while functional materials even in the form of disconnected clusters can be used for sensing. The reading of conductimetric chemical responses of clustered materials, in nominal operating conditions, is demonstrated by the generation of chemical images acquired for inversion biasing conditions. © 2004 American Institute of Physics.

  • 112.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Adaptive illumination in computer screen assisted spectral fingerprinting2005In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 86, no 8, p. 084101-Article in journal (Refereed)
    Abstract [en]

    The computer screen photoassisted technique (CSPT) uses displays as controlled light sources for measuring spectral fingerprints of color substances, such as those present in bioassays. Here, the possibility of tuning the illuminating sequences for matching CSPT fingerprints with target spectral transmittances is demonstrated. This approach enables robust classification, orders of magnitude form mismatches, and establish a systematic method for adapting optimum illuminating sequences to any unknown measuring platform. © 2005 American Institute of Physics.

  • 113.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical images generated by large area homogeneous illumination of metal-insulator-semiconductor structures2003In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 82, no 21, p. 3791-3793Article in journal (Refereed)
    Abstract [en]

    The induction of distinctive chemical images in the field-effect devices upon gas exposure by the use of a controlled large area illumination provided by a computer screen was reported. To generate two-dimensional photocurrent images, the concurrent optical and chemical modulation of the semiconductor surface potential of a single metal-oxide-semiconductor capacitor was used. It was concluded that the use of a computer screen as a programmable light source simplifies a normally complex setup.

  • 114.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical imaging by a computer screen aided scanning light pulse technique2002In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 81, no 20, p. 3891-3893Article in journal (Refereed)
    Abstract [en]

    The demonstration of a scanning light pulse technique (SLPT) for the generation of selective chemical images was done. The programmable light source provided by a standard cathode-rays tube computer screen was used for this purpose. The testing of the concept was done with a metal-oxide-semiconductor capacitor with catalytic gates of platinum and palladium spatially distributed in transversal directions.

  • 115.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Chemical sensing with computer screen photo-assisted techniques2005In: Eurosensors XIX,2005, 2005Conference paper (Refereed)
  • 116.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-assisted technique (CSPT) for personal and global monitoring2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster vid konferensen "Fobis Meeting", Stockholm, Sweden, 3 mars

  • 117.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Computer screen photo-assisted techniques2005In: Encyclopedia of Sensors / [ed] Craig A. Grimes, Gordon Grimes, Elizabeth E. Dickey, Michael V. Pishko, California, USA: American Scientific Publishers , 2005, p. -8000Chapter in book (Other academic)
    Abstract [en]

    The applications of sensors range from medical diagnostics to industrial manufacturing and to defense and national security applications. When an area spans such a large diversity of research, and where research from many different countries is also involved, a review of these developments becomes especially useful. Because it bridges science and technology the field also provides a desired interaction between researchers and research in technologically advanced and developing countries. The present series of volumes, "The Encyclopedia of Sensors" , the first of its kind, is intended to provide a timely compendium of the entire field. As such it can be expected to play a significant role in worldwide future progress and understanding."

  • 118.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Customizing the computer screen photo-assisted techniqe for evaluating quick diagnostic tests2005In: Nordic Baltic Conference in Biomedical Engineering and Medical Physics,2005, 2005, p. 215-Conference paper (Refereed)
  • 119.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Distinctive photocurrent chemical images on bare SiO2 between continuous metal gates2003In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 95, no 1-3, p. 116-122Conference paper (Other academic)
    Abstract [en]

    Distinctive two-dimensional chemical images of hydrogen, ammonia and nitrogen dioxide have been obtained using a scanning light pulse technique (SLPT) on a metal-oxide-semiconductor (MOS) device. The sensor consists of an MOS capacitor with two continuous metal gates of Pd (40nm) and Au (50nm) arranged in a concurrent geometry, leaving a bare silicon dioxide region in between the biased gates. The present arrangement provides a new robust alternative to the existing strategies used to induce spatially distributed chemical responses, required for SLPT and allows to measure the response in a different place than where the biasing electrodes operate. Accordingly, the splitting of biasing and detection coordinates enables to optimize electrical and chemical functions separately providing a higher versatility in the choice of functional sensing materials or stable biasing electrodes. © 2003 Elsevier B.V. All rights reserved.

  • 120.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Effect of fingerprint conformation and spectral scaling on the performance of computer screen photo-assisted experiments2006In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 131, no 1, p. 118-125Article in journal (Refereed)
    Abstract [en]

    The use of computer screens as controlled light sources and web cameras as image detectors (the so-called computer screen photo-assisted technique, CSPT) is an ubiquitous alternative for the evaluation of colorimetric quick tests at homes or in primary care units. The performance of CSPT for such evaluations depends on several factors, from which the most relevant are the composition of illuminating sequences and the conformation of CSPT substance signatures. In this work, with the aid of a CSPT model, the effect of the construction of the substance signatures on the classification performance of different representative substance sets is studied. The correlation of illuminating colors with such classification is investigated, allowing one to determine redundancy and limitations with respect to visible spectroscopy. The concept of spectral scaling is introduced and its properties compared with standard procedures. © The Royal Society of Chemistry 2006.

  • 121.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Hydrogen detection on bare SiO2 between metal gates2002In: Journal of Applied Physics, ISSN 0021-8979, E-ISSN 1089-7550, Vol. 91, no 6, p. 3896-3903Article in journal (Refereed)
    Abstract [en]

    Metal-oxide-semiconductor capacitors with gates of Pd and Au forming a wedge of bare SiO2 between them are described. It is observed that the sensitivity to H2 in the wedge is larger than on the outside of the metal gates due to the different distribution of potential determined by the geometrical constraints. The local response of the surface is obtained through the use of a scanning light pulse technique (SLPT), showing photocurrent versus voltage curves shifted to more negative voltages upon exposure to hydrogen. Within the wedge there is a two-dimensional photocurrent pattern composed of two splitting photocurrent peaks, whose separation depends on the distance between Au and Pd contacts, and on the composition of the ambient. The transient response in the wedge is comparable to that of Pd gates and the possibility of detecting hydrogen (or other molecules) by measuring on the bare insulator surface provides new possibilities for the use of field-effect structures for gas sensing. A semiempirical model describing the SLPT response for this particular geometry, conforms to experimental features, and highlights the sensitivity of the distribution of potential in the wedge to the density of charges induced on the semiconductor surface. © 2002 American Institute of Physics.

  • 122.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Illumination strategies for substance classification using a computer screen photo-assisted techique2005Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster Gordon Research Conference on Chemical Sensors and Interfacial Design 2005 Queens College, Oxford, UK

  • 123.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Measurement strategy and instrumental performance of a computer screen photo-assisted technique for the evaluation of a multi-parameter colorimetric test strip2006In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 131, no 1, p. 111-117Article in journal (Refereed)
    Abstract [en]

    A measuring strategy for the evaluation of a seven parameters colorimetric test using a computer screen photo-assisted technique (CSPT) is demonstrated. CSPT is a versatile approach aimed at point of care or home tests that uses regular computer sets and web cameras as the whole instrument. Issues such as the stability and the equivalency on different platforms of the determinations have been addressed in the present work. The method uses an embedded local reference simultaneously measured with the tests and solves the evaluation as a classification problem. The achieved performance tested along 580 classifications covering all the ranges of the assay, using synthetic samples, yielded 97.2% correct determinations compared with 89.7% for the case of colorimetric determinations. The errors were concentrated in only two parameters that show a significant correlation with a set of quality indices used to assess the performance of the classification. © The Royal Society of Chemistry 2006.

  • 124.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Measurements stategy and instrumental performance of a computer screen photo-assisted technique for the evaluation of a seven parameters colorimetric test2005Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster konferens Eurosenors XIX, Barcelona, Spanien

  • 125.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Preferential color substances and optimized illuminations for computer screen photo-assisted classification2006In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 5572006, p. 393-398Article in journal (Refereed)
  • 126.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Spectral characteristics of computer screen photoassisted classification2006In: Journal of Applied Physics, ISSN 0021-8979, E-ISSN 1089-7550, Vol. 99, no 11Article in journal (Refereed)
    Abstract [en]

    The computer screen photoassisted technique (CSPT) is a practical method for the classification of colored or fluorescent substances such as those present in bioassays but using standard computer sets and regular web cameras as all instruments. It is empirically known that the performance of the CSPT classification depends on the composition of the illuminating sequences displayed by the computer screens during the measurements, and by the way that substance fingerprints from these measurements are composed. Here the illuminating conditions are examined with the help of a CSPT model that allows to examine the physical grounds of optimum illuminating sequences different from just three screen primaries and to assess the limitations and importance of longer illuminating sequences in practical determinations. © 2006 American Institute of Physics.

  • 127.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Spectroscopic information retained in screen photo-assisted techniques2004In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 521, no 2, p. 237-244Article in journal (Refereed)
    Abstract [en]

    The computer screen photo-assisted technique (CSPT), a recently reported method for characterization of colorimetric assays, has been modeled and the ability of the technique to retain key spectral features has been determined. The robustness of CSPT to operate with different kind of screens is demonstrated and a physical explanation of the result is provided. Simulated CSPT transmittances corroborate experimental results, and enable comparison with standard methods for qualitative and quantitative evaluation. © 2004 Elsevier B.V. All rights reserved.

  • 128.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Test method2005Patent (Other (popular science, discussion, etc.))
  • 129.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimelli, A.
    DiNatale, C.
    Paolese, R.
    DAmico, A.
    Disposable e-nose based on spectral fingerprinting using a computer screen photo assisted technique2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Konferensbidrag (muntligt) vid "11th International Conference on Chemical Sensors - IMCS11, Brescia, Italy, 16-19 july

  • 130.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimelli, A.
    DiNatale, C.
    Paolesse, R.
    DAmico, A.
    CSPT fingerprinting of molecular interaction with porphyrins2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Konferensbidrag (muntligt) vid "International Conference of Porphyrins and Phthalocyanines ICPP-4", Rome, Italy, 2-7 july 

  • 131.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimelli, A.
    Paolesse, R.
    DAmico, A.
    DiNatale, C.
    Development of chemical sensors based on computer screen photo-assisted technology2006In: 11th ISEM,2006, 2006Conference paper (Other academic)
  • 132.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Alimelli, A.
    Paolesse, R
    DAmico, A.
    DiNatale, C.
    Fish freshness identification by a computer screen photoassisted sensor array2006Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster vid konferensen "11th International Conference on Chemical Sensors - IMCS11, Brescia, Italy, 16-19 july

  • 133.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Mandoj, F.
    Nardis, S.
    Verrelli, G.
    Paolesse, R.
    Alimelli, A.
    DiNatale, C.
    DAmico, A.
    Micozzi, A.
    Zinc-porphyrin conjugated polymer: a novel and versatile sensing material2006Other (Other (popular science, discussion, etc.))
  • 134.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Pennazza, G.
    Santonico, M.
    diNatale, C.
    Paolesse, R.
    Bellincontro, A.
    Mencarelli, F.
    DAmico, A.
    Sorting of apricots with computer screen photoassisted spectral reflectance analysis and electronic nose2006In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 119, no 1, p. 70-77Article in journal (Refereed)
    Abstract [en]

    Optical properties and aroma have been indicated as sources of information for the analysis of quality of fruits. Optical properties can be measured with several experimental arrangements and equipments that are often complex with result difficult to interpret. In recent years, a number of suggestions arose in the sensor community proposing the use of conventional computer peripheral devices as analytical instruments. Among them the combination of a computer screen and a webcam was demonstrated to be suitable to measure optical properties of materials. In this paper this arrangement is utilized to characterize the reflectance of apricot fruits that underwent different post-harvest treatment and mechanical damages. Optical measurements were complemented by aroma analysis with an electronic nose. The response of fruits to treatments was also monitored measuring CO2 (indicator of respiration) and ethylene (indicator of ripening), both these parameters are known to be influenced by post-harvest treatment and mechanical damages. Results show that a computer screen-webcam combination and an electronic nose are both sensitive to mechanical damages of fruits devising their use, after due optimization, for routine fruit sorting. © 2005.

  • 135.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Uchida, H.
    Faculty of Engineering, Saitama University, 255 Shimo-Okubo, Urawa 338, Japan.
    Gap-gate field effect gas sensing device for chemical image generation2004In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 84, no 15, p. 2946-2948Article in journal (Refereed)
    Abstract [en]

    A field effect chemically sensing device, suited for the generation of scanning light pulse technique (SLPT) chemical images, was proposed. The device was a MOS capacitor made on p-Si (10 ?), thermally oxidized to 120 nm and metallized on its underside with 200 nm of Al. The biasing electrodes were two parallel Al tracks 100 nm thick spaced 1 mm from each other. The results demonstrate the complete separation between biasing and sensing functions in devices designed for SLPT chemical image generation.

  • 136.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Manzano, J
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    LCD-aided computer screen photo-assisted technique for colorimetric assays evaluation2004In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 103, no 01-Feb, p. 158-164Article in journal (Refereed)
    Abstract [en]

    The ability of the computer screen photo-assisted technique (CSPT) to evaluate color samples through its light transmittance profiles is demonstrated by using liquid crystal displays (LCD) as light sources. Transmittance profiles are more drastically affected by angular dependencies than those obtained with CRT illumination. A local light reference computation is introduced to counteract this effect yielding equivalent profiles for both kinds of displays thus allowing for a broader universe of platforms to perform CSPT experiments, including mobile devices. (C) 2004 Elsevier B.V. All rights reserved.

  • 137.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Suska, Anke
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Customized illumination strategies in computer screen photo-assisted experiments2005Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Poster Konferens Eurosensors XIX, Barcelona, Spanien

  • 138.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Suska, Anke
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Natural nanosystems2007In: International Symposium on Biomolecular Nanoscale Assemblies,2007, 2007Conference paper (Refereed)
  • 139.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Tejle, Katarina
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    ELISA test for anti-neutrophil cytoplasm antibodies detection evaluated by a computer screen photo-assisted technique2005In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 21, no 2, p. 266-272Article in journal (Refereed)
    Abstract [en]

    The computer screen photo-assisted technique (CSPT), a method for substance classification based on spectral fingerprinting, which involves just a computer screen and a web camera as measuring platform is used here for the evaluation of a prospective enzyme-linked immunosorbent assay (ELISA). A anti-neutrophil cytoplasm antibodies (ANCA-ELISA) test, typically used for diagnosing patients suffering from chronic inflammatory disorders in the skin, joints, blood vessels and other tissues is comparatively tested with a standard microplate reader and CSPT, yielding equivalent results at a fraction of the instrumental costs. The CSPT approach is discussed as a distributed measuring platform allowing decentralized measurements in routine applications, whereas keeping centralized information management due to its natural network embedded operation. © 2004 Elsevier B.V. All rights reserved.

  • 140.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Winquist, Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-excited surface plasmon resonance imaging2008In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 625, no 2, p. 207-214Article in journal (Refereed)
    Abstract [en]

    Angle and spectra resolved surface plasmon resonance (SPR) images of gold and silver thin films with protein deposits is demonstrated using a regular computer screen as light source and a web camera as detector. The screen provides multiple-angle illumination, p-polarized light and controlled spectral radiances to excite surface plasmons in a Kretchmann configuration. A model of the SPR reflectances incorporating the particularities of the source and detector explain the observed signals and the generation of distinctive SPR landscapes is demonstrated. The sensitivity and resolution of the method, determined in air and solution, are 0.145 nm pixel-1, 0.523 nm, 5.13 × 10-3 RIU degree-1 and 6.014 × 10-4 RIU, respectively, encouraging results at this proof of concept stage and considering the ubiquity of the instrumentation. © 2008 Elsevier B.V. All rights reserved.

  • 141.
    Filippini, Daniel
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Åsberg, Peter
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Nilsson, Peter
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Inganäs, Olle
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Computer screen photo-assisted spectral fingerprinting of luminescent polythiophene pH reporter2004In: IEEE Sensors. Proceedings, ISSN 1930-0395, E-ISSN 2168-9229, Vol. 3, p. 1377-1380Article in journal (Refereed)
    Abstract [en]

    The capability of the computer screen photo-assisted technique (CSPT)for the spectral fingerprinting of a photoactive polythiophene derivative (POWT) used as pH reporter is demonstrated. POWT is part of a family of industrial scalable materials, well established for organic electronics and biomedical applications, which is used here to demonstrate the capability of CSPT for tracing key spectral features. The ability of CSPTfor substance classification, corroborated by principal component analysis (PCA), successfully compares to standard spectroscopy, especially considering the involved equipments: CSPT is only a computer set and a web camera.

  • 142.
    Filippini, Daniel
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Åsberg, Peter
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics .
    Nilsson, Peter
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics .
    Inganäs, Olle
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics .
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Computer screen photo-asssited detection of complementary DNA strands using a luminescent zwitterionic polythiophene derivative2006In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 1132006, p. 410-418Article in journal (Refereed)
  • 143. Fogelberg, J.
    et al.
    Dannetun, Helen
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Petersson, L.-G.
    A hydrogen sensitive palladium metal-oxide-semiconductor device as sensor for dissociating NO in H2-atmospheres1990In: Vacuum, ISSN 0042-207X, E-ISSN 1879-2715, Vol. 41, p. 705-Article in journal (Refereed)
    Abstract [en]

    A Pd-MOS structure can be used as a sensitive analytical tool in the study of dissociating oxygen containing molecules. Nitric oxide has been studied as a test case. Initially NO adsorbs very effectively and dissociatively on polycrystalline Pd at temperatures above 473 K. At this temperature H2O, N2O and N2 desorbs during an NO exposure in a hydrogen background. After such exposure the surface is probably left with only residual nitrogen atoms adsorbed on the surface. Below 390 K the dissociation probability is insignificant.

  • 144.
    Garvin, Peter
    et al.
    Linköping University, Department of Medical and Health Sciences, Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Kristenson, Margareta
    Linköping University, Department of Medical and Health Sciences, Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Public Health Sciences.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    SALIVARY ALPHA-AMYLASE IN A POPULATION BASED SAMPLE. ASSOCIATIONS WITH PSYCHOSOCIAL FACTORS, SELF RATED HEALTH AND INFLAMMATORY MARKERS2010In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 17, no 1 Supplement, p. S181-S181Article in journal (Other academic)
    Abstract [en]

    Objective: In recent years, salivary alpha-amylase (sAA) has beenproposed as a reliable proxy for sympathetic activity. This study aimed at testing the association between sAA to a broad range of psychosocial factors, self rated health, cardiovascular risk factors and inflammatory markers in a normal population sample.

    Methods: 30 participants, all men between 50 and 54 years old, were randomly selected from a normal population based study. Saliva samples were collected at awakening, 30 minutes after awakening and just before going to bed. sAA was measured by a calorimetric method using Phadebas amylase test. Linear regression models were used to test associations between sAA levels and a broad spectrum of psychosocial factors (e.g. depressive symptamology, vital exhaustion, mastery and sense of coherence) self rated health and inflammatory markers (e.g. C-reactive protein). Adjustments were made for physical exercise, smoking, blood  lipids and  time point  when  sample was collected.

    Results: sAA levels at awakening were positively associated with depressive symptamology (p = 0.046), vital exhaustion (p = 0.025) and negatively associated with sense of coherence (p = 0.034). It was further associated positively associated with levels of C-reactive protein (p = 0.024)  and  negatively associated with  self  reported general health (p = 0.010). Samples taken just before going to bed were showing similar results, whereas samples taken 30 minutes after awakening only showed a few significant associations.

    Conclusions: The associations found give further support for the use of salivary alpha amylase as a psychoneuroendocrinological bio- marker. Assessment just after awakening or just before going to bed seems to be more reliable than samples 30 minutes after awakening.

  • 145.
    Gatto, E.
    et al.
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
    Malik, Muhammad Ali
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Di, Natale C.
    Di Natale, C., Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy.
    Paolesse, R.
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
    D'Amico, A.
    Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Filippini, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
    Polychromatic fingerprinting of excitation emission matrices2008In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 14, no 20, p. 6057-6060Article in journal (Refereed)
    Abstract [en]

    The ability of a ubiquitous polychromatic excitation to support the fingerprinting of the Excitation Emission Matrices (EEM) of fluorescent indicators was reported. Solutions of fluorescent molecules, with concentration of 2µM for the absorption and 10µM for the emission measurements were prepared. Spectroscopic grade THF and distilled water passed through Milli-Q purification system were used as solvents. EEM measurements were carried out on a spectrofluorimeter, operating in the 390-700 nm detection range, with excitations at 20 nm intervals within the same range. During the measurement, the screen displayed a sequence of 50 colors and for every color, the transmission and emission spectrum of both the reference and the sample were recorded. Illuminating colors in the red region are not able to excite fluorescence and this can be seen in the spectra for red light.

  • 146.
    Guanais Goncalves, Carla
    et al.
    University of Roma Tor Vergata, Italy.
    Dini, Francesca
    University of Roma Tor Vergata, Italy.
    Martinelli, Eugenio
    University of Roma Tor Vergata, Italy.
    Catini, Alexandro
    University of Roma Tor Vergata, Italy.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Paolesse, Roberto
    University of Roma Tor Vergata, Italy.
    Di Natale, Corrado
    University of Roma Tor Vergata, Italy.
    Detection of diverse potential threats in water with an array of optical sensors2016In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 236, p. 997-1004Article in journal (Refereed)
    Abstract [en]

    Optical sensor arrays are widely used for sensing the evolution and the identification of complex patterns of chemicals either in air or in water. This popularity stems from the fact that low-cost, ready-to-use optical devices, made available by the current commercial development of electronics commodities, are complemented by a number of low-cost chemical indicators, suitable for a wide range of applications. Among them, pH indicators, and metalloporphyrins make a solid library of molecules that can be adequately assembled for many different tasks. Here, such an array is used for the identification of toxic compounds of different origin that may be released in water distribution systems as a consequence of either accidents or deliberated contaminations. The compounds considered are intermediate products of chemical industry (dimethyl methylphosphonate and cyclohexanone), drugs (5-Fluorouracil and piperazine) and pesticides (imidacloprid and paraoxon). Results show that the sensors are sensitive, but with low selectivity, in the interval from 10(-7) mol L-1 to 10(-4) mol L-1. The sensor signals show a linear correlation with the logarithm of the concentration. Although the limited selectivity of individual sensors, the different sensitivity patterns allow for a clear identification of the compounds, independent of their concentration.(C) 2016 Elsevier B.V. All rights reserved.

  • 147.
    Hammarström, Per
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
    Ali, Malik M
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Mishra, Rajesh
    Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
    Salagic, Belma
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Svensson, Samuel
    AstraZeneca RandD.
    Tengvall, Pentti
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
    An Auto-Catalytic Surface for Conformational Replication of Amyloid Fibrils-Genesis of an Amyloid World?2011In: Origins of life and evolution of the biosphere, ISSN 0169-6149, E-ISSN 1573-0875, Vol. 41, no 4, p. 373-383Article in journal (Refereed)
    Abstract [en]

    Amyloid fibrils are composed of self assembled stacked peptide or protein molecules folded and trapped in a stable cross-beta-sheet conformation. The amyloid fibrillation mechanism represents an intriguing self-catalyzed process rendering replication of a molecular conformational memory of interest for prebiotic chemistry. Herein we describe how a solid surface can be rendered auto-catalytic for fibrillation of a protein solution. We have discovered that a hydrophobic silicon or glass surface can be made to continuously fibrillate solutions of insulin monomers under stressed conditions (pH 1.6, 65 degrees C). It was found that the surface acts as a platform for the formation of nascent seeds that induce fibril replication on and at the surface. This autocatalytic effect stems from a layer a few insulin molecules thick representing an oligomeric layer of misfolded, conformationally trapped, insulin molecules that rapidly through epitaxial growth catalyze the rate determining step (nucleation) during fibril replication. This autocatalytic layer is generated by the protein-solid surface interaction and conformational changes of the adsorbed protein during exposure at the air-water interface. The resulting autocatalytic surface thus both initiates local conformational molecular self-replication and acts as a reservoir for fibril seeds budding off into solution spreading fibril replication entities to the surrounding medium. The possibility of catalysis of the conformational replication process by minute amounts of nucleation sites located on a recruiting surface can evade the issue of dramatic concentration dependence of amyloidogenesis.

  • 148.
    Hammarström, Per
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
    Ali Malik, Muhammad
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Mishra, Rajesh
    Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
    Svensson, Samuel
    Linköping University, Department of Medicine and Health Sciences, Pharmacology . Linköping University, Faculty of Health Sciences.
    Tengvall, Pentti
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
    A catalytic surface for amyloid fibril formation2008In: Journal of Physics, Conference Series, ISSN 1742-6588, E-ISSN 1742-6596, Vol. 100Article in journal (Refereed)
    Abstract [en]

    A hydrophobic surface incubated in a solution of protein molecules (insulin monomers) was made into a catalytic surface for amyloid fibril formation by repeatedly incubate, rinse and dry the surface. The present contribution describes how this unexpected transformation occurred and its relation to rapid fibrillation of insulin solutions in contact with the surface. A tentative model of the properties of the catalytic surface is given, corroborated by ellipsometric measurements of the thickness of the organic layer on the surface and by atomic force microscopy. The surfaces used were spontaneously oxidized silicon made hydrophobic through treatment in dichlorodimethylsilane.

  • 149.
    Hansson, Kenny
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Johansen, Knut
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Wetterö, Jonas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Rheumatology.
    Klenkar, Goran
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics.
    Benesch, Johan
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Lundström, Ingemar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Lindahl, Tomas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of clinical chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
    Tengvall, Pentti
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics.
    Surface plasmon resonance detection of blood coagulation and platelet adhesion under venous and arterial shear conditions2007In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 23, no 2, p. 261-268Article in journal (Refereed)
    Abstract [en]

    A surface plasmon resonance (SPR) based flow chamber device was designed for real time detection of blood coagulation and platelet adhesion in platelet rich plasma (PRP) and whole blood. The system allowed the detection of surface interactions throughout the 6 mm length of the flow chamber. After deposition of thromboplastin onto a section of the sensor surface near the inlet of the flow chamber, coagulation was detected downstream of this position corresponding to a SPR signal of 7 to 8 mRIU (7 to 8 ng/mm2). A nonmodified control surface induced coagulation 3.5 times slower. Platelet adhesion to gold and fibrinogen coated surfaces in the magnitude of 1.25 and 1.66 mRIU was also shown with platelets in buffer, respectively. SPR responses obtained with PRP and whole blood on surfaces that were methylated or coated with von Willebrand factor (vWF), fibrinogen, or collagen, coincided well with platelet adhesion as observed with fluorescence microscopy in parallel experiments. The present SPR detection equipped flow chamber system is a promising tool for studies on coagulation events and blood cell adhesion under physiological flow conditions, and allows monitoring of short-range surface processes in whole blood. © 2007 Elsevier B.V. All rights reserved.

  • 150.
    Hansson, Kenny M.
    et al.
    Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
    Tengvall, Pentti
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Rånby, Mats
    Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
    Lindahl, Tomas L.
    Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
    Surface plasmon resonance and free oscillation rheometry in combination: A new approach forstudies on haemostasis and biomaterialsManuscript (preprint) (Other academic)
    Abstract [en]

    In haemostasis and biomaterial research it is important to be able to study biological processes at surfaces and in the bulk. Surface plasmon resonance (SPR) is sensitive to changes at surface and free oscillation rheometry (FOR) probes the bulk. The present work demonstrates the usefulness of the combination of the techniques for simultaneous real-time measurements on coagulation and fibrinolysis of blood plasma, as well as coagulation of whole blood. SFLLRN stimulated coagulation of native whole blood presented a higher SPR signal with a different appearance than for plasma coagulation, while the FOR signals corresponding to plasma and whole blood coagulation were similar. This result indicated that the SPR technique was more sensitive to cell-surface interactions than to fibrin formation in whole blood, while the FOR technique were equally sensitive to coagulation in whole blood and plasma. Spontaneous coagulation of native whole blood in contact with methyland hydroxyl-terminated self-assembled monolayers on gold and gold surfaces regenerated after coagulation by degradation of adsorbed proteins with trypsin and SOS were also studied. The regenerated gold surfaces displayed the shortest coagulation times, although the contact-activation of blood coagulation was found to be low. The methylated and hydroxylated surfaces were comparable in terms of coagulation activation, while the hydroxylated surfaces presented FOR signals that indicated difficulties for the coagulum to attach to the surface. The combination of SPR and FOR may be suited for studies of cell-surface interactions, and may find applications in studies of blood cell defects in patients and testing of medical substances.

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