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  • 101.
    Fyrenius, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Wigström, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Bolger, Ann F.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Öhman, Peter
    Linköpings universitet, Institutionen för medicin och vård, Internmedicin. Linköpings universitet, Hälsouniversitetet.
    Karlsson, Matts
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk modellering och simulering. Linköpings universitet, Tekniska högskolan.
    Wranne, Bengt
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Pitfalls in Doppler evaluation of diastolic function: insights from three-dimensional magnetic resonance imaging1999Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 12, nr 10, s. 817-826Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Ultrasound-Doppler assessment of diastolic function is subject to velocity errors caused by angle sensitivity and a fixed location of the sample volume. We used 3-dimensional phase contrast magnetic resonance imaging (MRI) to evaluate these errors in 10 patients with hypertension and in 10 healthy volunteers. The single (Doppler) and triple (MRI) component velocity was measured at early (E) and late (A) inflow along Doppler-like sample lines or 3-dimensional particle traces generated from the MRI data. Doppler measurements underestimated MRI velocities by 9.4% ± 8.6%; the effect on the E/A ratio was larger and more variable. Measuring early and late diastolic inflows from a single line demonstrated the error caused by their 3-dimensional spatial offset. Both errors were minimized by calculating the E/A ratio from maximal E and A values without constraint to a single line. Alignment and spatial offset are important sources of error in Doppler diastolic parameters. Improved accuracy may be achieved with the use of maximal E and A velocities from wherever they occur in the left ventricle.

  • 102.
    Fyrenius, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Wigström, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Karlsson, Matts
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk modellering och simulering. Linköpings universitet, Tekniska högskolan.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Bolger, Ann F.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Three-dimensional flow in the human left atrium2001Ingår i: Heart, ISSN 1355-6037, Vol. 86, nr 4, s. 448-455Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Abnormal flow patterns in the left atrium in atrial fibrillation or mitral stenosis are associated with an increased risk of thrombosis and systemic embolisation; the characteristics of normal atrial flow that avoid stasis have not been well defined.

    OBJECTIVES: To present a three dimensional particle trace visualisation of normal left atrial flow in vivo, constructed from flow velocities in three dimensional space.

    METHODS: Particle trace visualisation of time resolved three dimensional magnetic resonance imaging velocity measurements was used to provide a display of intracardiac flow without the limitations of angle sensitivity or restriction to imaging planes. Global flow patterns of the left atrium were studied in 11 healthy volunteers.

    RESULTS: In all subjects vortical flow was observed in the atrium during systole and diastolic diastasis (mean (SD) duration of systolic vortex, 280 (77) ms; and of diastolic vortex, 256 (118) ms). The volume incorporated and recirculated within the vortices originated predominantly from the left pulmonary veins. Inflow from the right veins passed along the vortex periphery, constrained between the vortex and the atrial wall.

    CONCLUSIONS: Global left atrial flow in the normal human heart comprises consistent patterns specific to the phase of the cardiac cycle. Separate paths of left and right pulmonary venous inflow and vortex formation may have beneficial effects in avoiding left atrial stasis in the normal subject in sinus rhythm.

  • 103.
    Fyrenius, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Wirell, Staffan
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Silén, Charlotte
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Student approaches to achieving understanding ― Approaches to learning revisited2007Ingår i: Studies in Higher Education, ISSN 0307-5079, Vol. 32, nr 2, s. 149-165Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This article presents a phenomenographic study that investigates students' approaches to achieving understanding. The results are based on interviews, addressing physiological phenomena, with 16 medical students in a problem-based curriculum. Four approaches—sifting, building, holding and moving—are outlined. The holding and moving approaches describe variations in deep-level processing. The moving approach is characterised by an intention to continuously refine understanding in an open-ended process. The student strives for a change in perspective and deliberately creates actions that are rich in variation and challenge. The holding approach is characterised by an intention to reach a final goal. This is achieved by high degrees of structure and control in the learning act. Understanding is sometimes sealed, 'held on to' and can be threatened by new input and other students' viewpoints. The study also shows how students deal with details when constructing understanding of wholes.

  • 104.
    Georgiopoulos, Charalampos
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping.
    Davidsson, Anette
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Granerus, Göran
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Dizdar (Dizdar Segrell), Nil
    Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk kemi.
    Zachrisson, Helene
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    DaTSCAN SPECT EVALUATION OF PATIENTS WITH MOVEMENT DISORDERS2011Ingår i: EUROPEAN JOURNAL OF NEUROLOGY, Wiley-Blackwell, 2011, Vol. 18 (Suppl. 2), nr SI, s. 567-567, artikel-id P2617Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    Introduction: Molecular imaging with DaTSCAN SPECTis widely used as a diagnostic tool in patients with movementdisorders in the form of Parkinson's Disease (PD),Parkinson-plus syndromes and Tremor. In the present studythe potency of DATScan SPECT to detect degeneration inthe basal ganglia in early stages of PD, before the onset ofmedication, is evaluated. In addition the efficacy ofDaTSCAN for differential diagnosis between patients withidiopathic PD and patients with Parkinson-plus syndromesis examined.

    Methodology: Participants: 21 patients with PD in earlystages, before the onset of medication, 20 patients withidiopathic PD and 6 patients with Parkinson-plussyndromes. 15 participants with normal results ofDaTSCAN SPECT and a clinical diagnosis different fromPD or Parkinson-plus were used as control.

    DaTSCAN SPECT: In the present study the quantificationof Striatum Occipital/Occipital and the Xeleris workstation(GE) were used.

    Results: The quantification for patients with idiopathic PD(1.185±0.05687) was significantly lower (p<0.0001) fromthe control (2.369±0.1258) and significantly lower (p<0.05)from that of patients in early stages of PD, before the onsetof medication (1.359±0.05324). There was no significantdifference between the idiopathic PD and Parkinson-plussyndromes (1.103±0.2442).

    Conclusion: DaTSCAN SPECT can detect efficiently earlydegeneration in the basal ganglia before the onset ofmedication is needed. Its efficacy for the differentialdiagnosis between idiopathic PD and Parkinson-plussyndromes is questioned. The combination of imaging andclinical examination is mandatory for a certain diagnosis.

  • 105.
    Gunningberg, Lena
    et al.
    Uppsala University.
    Brudin, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Idvall, Ewa
    Malmö University.
    Nurse Managers prerequisite for nursing development: a survey on pressure ulcers and contextual factors in hospital organizations2010Ingår i: JOURNAL OF NURSING MANAGEMENT, ISSN 0966-0429, Vol. 18, nr 6, s. 757-766Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aim To describe and compare pressure ulcer prevalence in two county councils and concurrently explore Nurse Managers perspective of contextual factors in a hospital organization. Background Despite good knowledge about risk factors and prevention of pressure ulcers, the prevalence of pressure ulcers remains high. Nurse Managers have a key role in implementing evidence-based practice. Methods The present study included five hospitals in two Swedish county councils: county council A (non-university setting) and county council B (university setting). A pressure ulcer prevalence study was conducted according to the methodology developed by the European Pressure Ulcer Advisory Panel. The Nurse Managers answered a (27-item) questionnaire on contextual factors. Results County council B had significantly less pressure ulcers grade (2-4) (7.7%) than county council A (11.3%). The Nurse Managers assessed only two out of the 27 general contextual items significantly differently. Some significant differences were observed in ward organization. Conclusions In county council B, the Nurse Managers seemed more aware of prevention strategies compared with Nurse Managers in county council A. The Nurse Managers should take more responsibility to develop the prerequisite for quality improvement in nursing. Implication for nursing management Nursing outcomes (e. g. pressure ulcers) should be incorporated into national quality registries for benchmarking and Nurse Managers competence in evidence-based practice and research methodology increased.

  • 106.
    Gustafsson, Agneta
    et al.
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Radiofysikavdelningen.
    Granerus, Göran
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Zachrisson, Helene
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Evaluation of the OSEM reconstruction techniques used in DATscan.2008Ingår i: Nuklearmedicinska vårmötet,2008, 2008Konferensbidrag (Refereegranskat)
  • 107.
    Gustafsson, Håkan
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Berg, Kirsti
    Norwegian University of Science and Technology.
    Lindgren, Mikael
    Norwegian University of Science and Technology.
    Engström, Maria
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    De Muinck, Ebo
    Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Zachrisson, Helene
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Fe(3+) Heterogeneity in Ex Vivo Carotid Atherosclerotic Plaques2011Ingår i: Free Radical Biology & Medicine, ISSN 0891-5849, E-ISSN 1873-4596, Vol. 51, nr Suppl. 1, s. S40-S40Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    n/a

  • 108.
    Gustafsson, Håkan
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Norell, M.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Lindgren, M.
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Engström, Maria
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Rosén, A.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
    Zachrisson, Helene
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Is vulnerability for carotid plaque rupture related to intrinsic Fe (III) distribution2012Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    Atherosclerotic plaques vulnerable for rupture are characterised by e.g., a large lipid pole, a high concentration of inflammatory cells and a thin fibrous cap. Recent research has showed that vulnerable plaques are structurally weaker and therefore more likely to rupture in response to physical forces; possible due to high local concentrations of macrophages and reactive oxygen species (ROS).  It is well known that redox active iron catalyses production of ROS and that the presence of Fe(III) is linked to ROS production. The aim of this study was to investigate the distribution of Fe(III) in carotid plaques.

  • 109.
    Gustafsson, Per
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Pediatrik. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Oesophageal function, acid reflux and bronchopulmonary disease: A study on children and adolescents with asthma or cystic fibrosis1991Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    This thesis comprises a literature review of gastro-ocsophageal reflux (GOR) and six studies which aim to determine the prevalence of oesophageal dysfunction (OD) and pathological GOR and their significance concerning the bronchopulmonary disease in children and adolescents with bronchial asthma or cystic fibrosis (CF). Oesophageal function was assessed by manomctry combined with oesophageal provocation tests. 24-hour two-level oesophageal pH monitoring was used to quantify GOR, to study the temporal relationship between acid reflux and asthma symptoms, and to assess the propensity to aspirate. Symptoms of OD and asthma were evaluated by interview and by the use of questionnaires. Severity of bronchopulmonary disease in the CF patients was assessed by radiography and spirometry. A double-blind placebo-controlled trial of ranitidine 150/300 mg per day over four weeks was performed in the asthma group to see if a reduction in acid reflux improved asthma. The relative significance of reflux symptoms and atopic allergy, regarding lung function and bronchial histamine reactivity in asthma, was evaluated. Pathological GOR and OD were significantly more common in asthma and CF patients than in controls. Episodes of acid reflux seemed to provoke asthma symptoms in a few patients. Ranitidine produced a significant but modest reduction in nocturnal/morning asthma symptoms in patients with pathological GOR, when compared to those with normal GOR. Asthma patients with reflux symptoms more frequently experienced asthma attacks initiated by non-specifictrigger factors than patients without such symptoms. The presence of atopic allergy was related to impaired lung function and increased bronchial hyperreactivity. Severity of OD and bronchopulmonarydisease correlated well in CF patients.

    OD or pathological GOR are found in the majority of children and adolescents with asthma or CF. In CF subjects OD and GOR may be parts of a vicious circle including malnutrition and progressive lung damage. In asthma acid reflux is, on the whole, a mild trigger or a modulatory factor, and appears to influence the airways via oesophago-bronchial reflexes rather than by aspiration. Atopic allergy is still more important than GOR in childhood asthma.

  • 110.
    Hammar, Mats
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Persson, Anne-Christine
    Linköpings universitet, Hälsouniversitetet.
    Fyrenius, Anna
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Antepohl, Wolfram
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Rehabiliteringsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Rekonstruktionscentrum, Rehabiliteringsmedicinska kliniken US.
    Obituray: Professor Björn Bergdahl - a pioneer in Swedish medical education2010Ingår i: Medical teacher, ISSN 0142-159X, E-ISSN 1466-187X, Vol. 32, nr 9, s. 788-788Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    Professor Björn Bergdahl, MD, one of the founders of the Faculty of Health Sciences (FHS) at Linköping University, passed away in March 2009. He left us all in grief and disbelief. How could we manage without him?

    Professor Bergdahl graduated with a degree in medicine from Lund University and was recruited to the internal medicine clinic at the University Hospital of Linköping in 1968. After completing his postgraduate studies, he began to teach medical students in 1977. This was the start of a life-long commitment to medical education. He was the first clinical teacher in Sweden ever to be promoted to the position of professor on scientific as well as teaching merits....

  • 111.
    Haraldsson, Henrik
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Assessment of Myocardial Function using Phase Based Motion Sensitive MRI2010Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Quantitative assessment of myocardial function is a valuable tool for clinical applications and physiological studies. This assessment can be acquired using phase based motion sensitive magnetic resonance imaging (MRI) techniques. In this thesis, the accuracy of these phase based motion sensitive MRI techniques is investigated, and modifications in acquisition and post-processing are proposed.

    The strain rate of the myocardium can be used to evaluate the myocardial function. However, the estimation of strain rate from the velocity data acquired with phase-contrast MRI (PC-MRI) is sensitive to noise. Estimation using normalized convolution showed, however, to reduce this sensitivity to noise and to minimize the influence of non-myocardial tissue which could impair the result.

    Strain of the myocardium is another measure to assess myocardial function. Strain can be estimated from the myocardial displacement acquired with displacement encoding with stimulated echo (DENSE). DENSE acquisition can be realized with several different encoding strategies. The choice of encoding scheme may make the acquisition more or less sensitive to different sources of error. Two potential sources of errors in DENSE acquisition are the influence of the FID and of  the off-resonance effects. Their influence on DENSE were investigated to determine suitable encoding strategies to reduce their influence and thereby improve the measurement accuracy acquired.

    The quality of the DENSE measurement is not only dependent on the accuracy, but also the precision of the measurement. The precision is affected by the SNR and thereby depends on flip angle strategies, magnetic field strength and spatial variation of the receiver coil sensitivity. A mutual comparison of their influence on SNR in DENSE was therefore performed and could serve as a guideline to optimize parameters for specific applications.

    The acquisition time is often an important factor, especially in clinical applications where it affects potential patient discomfort and patient through-put. A multiple-slice DENSE acquisition was therefore presented, which allows the acquisition of strain values according to the 16-segment cardiac model within a single breath-hold, instead of the conventional three breath-holds.

    The DENSE technique can also be adapted toward comprehensive evaluation of the heart in the form of full three-dimensional three-directional acquisition of the displacement. To estimate the full strain tensor from these data, a novel post-processing technique using a polynomial was investigated. The method yielded accurate results on an analytical model and \textit{in-vivo} strains obtained agreed with previously reported myocardial strains in normal volunteers.

    Delarbeten
    1. Improved estimation and visualization of two-dimensional myocardial strain rate using MR velocity mapping
    Öppna denna publikation i ny flik eller fönster >>Improved estimation and visualization of two-dimensional myocardial strain rate using MR velocity mapping
    Visa övriga...
    2008 (Engelska)Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 28, nr 3, s. 604-611Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Purpose: To estimate regional myocardial strain rate, with reduced sensitivity to noise and velocities outside the region of interest, and provide a visualization of the spatial variation of the obtained tensor field within the myocardium. Materials and Methods: Myocardial velocities were measured using two-dimensional phase contrast velocity mapping. Velocity gradients were estimated using normalized convolution and the calculated 2D strain rate tensor field was visualized using a glyph representation. Validation utilized a numerical phantom with known strain rate distribution. Strain rate glyph visualizations were created for normal myocardium in both systole and diastole and compared to a patient with an anteroseptal infarction. Results: In the phantom study the strain rate calculated with normalized convolution showed a very good agreement with the analytic solution, while traditional methods for gradient estimation were shown to be sensitive to both noise and surrounding velocity data. Normal myocardium showed a homogenous strain rate distribution, while a heterogeneous strain rate can be clearly seen in the patient data. Conclusion: The proposed approach for quantification and visualization of the regional myocardial strain rate can provide an objective measure of regional myocardial contraction and relaxation that may be valuable for the assessment of myocardial heart disease. © 2008 Wiley-Liss, Inc.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-43136 (URN)10.1002/jmri.21471 (DOI)000259106900007 ()71981 (Lokalt ID)71981 (Arkivnummer)71981 (OAI)
    Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13
    2. Influence of the FID and off-resonance effects in dense MRI
    Öppna denna publikation i ny flik eller fönster >>Influence of the FID and off-resonance effects in dense MRI
    Visa övriga...
    2011 (Engelska)Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 65, nr 4, s. 1104-1112Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Accurate functional measurement in cardiovascular diseases is important as inaccuracy may compromise diagnostic decisions. Cardiac function can be assessed using displacement encoding with stimulated echoes, resulting in three signal components. The free induction decay (FID), arising from spins undergoing T1-relaxation, is not displacement encoded and impairs the displacement acquired. Techniques for suppressing the FID exist; however, a residual will remain. The effect of the residual is difficult to distinguish and investigate in vitro and in vivo. In this work, the influence of the FID as well as of off-resonance effects is evaluated by altering the phase of the FID in relation to the stimulated echo. The results show that the FID and off-resonance effects can impair the accuracy of the displacement measurement acquired. The influence of the FID can be avoided by using an encoded reference. We therefore recommend the assessment of this influence of the FID for each displacement encoding with stimulated echoes protocol.

    Ort, förlag, år, upplaga, sidor
    Wiley, 2011
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-60266 (URN)10.1002/mrm.22692 (DOI)000288612000023 ()
    Tillgänglig från: 2010-10-08 Skapad: 2010-10-08 Senast uppdaterad: 2017-12-12
    3.
    Posten kunde inte hittas. Det kan bero på att posten inte längre är tillgänglig eller att du har råkat ange ett felaktigt id i adressfältet.
    4. Single Breath Hold Multiple Slice DENSE MRI
    Öppna denna publikation i ny flik eller fönster >>Single Breath Hold Multiple Slice DENSE MRI
    Visa övriga...
    2010 (Engelska)Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 63, nr 5, s. 1411-1414Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    A method to acquire multiple displacement encoded slices within asingle breath hold is presented. Efficiency is improved overconventional Displacement ENcoding with Stimulated Echoes (DENSE) without compromising image quality by read-out of multiple slices inthe same cardiac cycle, thus utilizing the position encoded stimulatedecho available in the whole heart. The method was evaluated bycomparing strain values obtained using the proposed method to strainvalues obtained by conventional separate breath hold single-sliceDENSE acquisitions. Good agreement (Lagrangian E2 strainbias=0.000, 95% limits of agreement ±0.04,root-mean-square-difference 0.02 (9.4% of the mean end-systolic E2)) was found between the methods, indicating that the proposedmethod can replace a multiple breath hold acquisition. Eliminating theneed for multiple breath holds reduces the risk of changes in breathhold positions or heart rate, results in higher patient comfort andfacilitates inclusion of DENSE in a clinical routine protocol.

    Ort, förlag, år, upplaga, sidor
    John Wiley and Sons, Ltd, 2010
    Nyckelord
    DENSE, strain, multi-slice, breath hold, cardiac function
    Nationell ämneskategori
    Medicinsk laboratorie- och mätteknik
    Identifikatorer
    urn:nbn:se:liu:diva-51974 (URN)10.1002/mrm.22305 (DOI)000277098100030 ()
    Tillgänglig från: 2009-11-25 Skapad: 2009-11-25 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
    5. Myocardial strains from 3D DENSE magnetic resonance imaging
    Öppna denna publikation i ny flik eller fönster >>Myocardial strains from 3D DENSE magnetic resonance imaging
    Visa övriga...
    (Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    The ability to measure and quantify myocardial motion and deformation provides a useful tool to assist in the diagnosis, prognosis and management of heart disease. The recent development of magnetic resonance imaging methods, such as harmonic phase and displacement encoding with stimulated echoes (DENSE), make detailed non-invasive 3D transmural kinematic analyses of human myocardium possible in the clinic and for research purposes. As data acquisition technologies improve, quantification methods for cardiac kinematics need to be adapted and validated on the new types of data. In the present paper, a previously presented polynomial method for cardiac strain quantification is extended to quantify 3D strains from DENSE magnetic resonance imaging data. The method yields accurate results when validated against an analytical standard, and is applied to in vivo data from a healthy  human heart. The polynomial field is capable of resolving the measured material positions from the in vivo data, and the obtained in vivo strains agree

    Nyckelord
    Strain, 3D, myocardium, DENSE, transmural
    Nationell ämneskategori
    Teknik och teknologier
    Identifikatorer
    urn:nbn:se:liu:diva-60201 (URN)
    Tillgänglig från: 2010-10-07 Skapad: 2010-10-07 Senast uppdaterad: 2016-03-14
  • 112.
    Haraldsson, Henrik
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Sigfridsson, A.
    Mie University, Tsu, Mie, Japan.
    Sakuma, H.
    Mie University, Tsu, Mie, Japan.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Comparison of DENSE Reference Strategies2009Ingår i: Proceedings of the International Society for Magnetic Resonance in Medicine, 2009, s. 819-819Konferensbidrag (Refereegranskat)
  • 113.
    Haraldsson, Henrik
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Sakuma, Hajime
    Engvall, Jan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Ebbers, Tino
    Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Influence of the FID and off-resonance effects in dense MRI2011Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 65, nr 4, s. 1104-1112Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Accurate functional measurement in cardiovascular diseases is important as inaccuracy may compromise diagnostic decisions. Cardiac function can be assessed using displacement encoding with stimulated echoes, resulting in three signal components. The free induction decay (FID), arising from spins undergoing T1-relaxation, is not displacement encoded and impairs the displacement acquired. Techniques for suppressing the FID exist; however, a residual will remain. The effect of the residual is difficult to distinguish and investigate in vitro and in vivo. In this work, the influence of the FID as well as of off-resonance effects is evaluated by altering the phase of the FID in relation to the stimulated echo. The results show that the FID and off-resonance effects can impair the accuracy of the displacement measurement acquired. The influence of the FID can be avoided by using an encoded reference. We therefore recommend the assessment of this influence of the FID for each displacement encoding with stimulated echoes protocol.

  • 114.
    Haraldsson, Henrik
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Wigström, Lars
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Lundberg, Magnus
    Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet.
    Bolger, Ann F
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Engvall, Jan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Escobar Kvitting, John-Peder
    Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet.
    Improved estimation and visualization of two-dimensional myocardial strain rate using MR velocity mapping2008Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 28, nr 3, s. 604-611Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To estimate regional myocardial strain rate, with reduced sensitivity to noise and velocities outside the region of interest, and provide a visualization of the spatial variation of the obtained tensor field within the myocardium. Materials and Methods: Myocardial velocities were measured using two-dimensional phase contrast velocity mapping. Velocity gradients were estimated using normalized convolution and the calculated 2D strain rate tensor field was visualized using a glyph representation. Validation utilized a numerical phantom with known strain rate distribution. Strain rate glyph visualizations were created for normal myocardium in both systole and diastole and compared to a patient with an anteroseptal infarction. Results: In the phantom study the strain rate calculated with normalized convolution showed a very good agreement with the analytic solution, while traditional methods for gradient estimation were shown to be sensitive to both noise and surrounding velocity data. Normal myocardium showed a homogenous strain rate distribution, while a heterogeneous strain rate can be clearly seen in the patient data. Conclusion: The proposed approach for quantification and visualization of the regional myocardial strain rate can provide an objective measure of regional myocardial contraction and relaxation that may be valuable for the assessment of myocardial heart disease. © 2008 Wiley-Liss, Inc.

  • 115.
    Hedlund, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet.
    Ahrén, Maria
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Ytors Fysik och Kemi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska högskolan.
    Gustafsson, Håkan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Abrikossova, Natalia
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Warntjes, Marcel
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Jönsson, Jan-Ingvar
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Experimentell hematologi. Linköpings universitet, Hälsouniversitetet.
    Uvdal, Kajsa
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Sensorvetenskap och Molekylfysik. Linköpings universitet, Tekniska högskolan.
    Engström, Maria
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Detection of Gd2O3 Nanoparticles in Hematopoietic Cells for MRI Contrast EnhancementManuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    As the utility of magnetic resonance imaging (MRI) broadens, the importance of having specific and efficient contrast agents increases and there has been a huge development in the fields of molecular imaging and intracellular markers.

    Previous studies have shown that gadolinium oxide (Gd2O3 ) nanoparticles generate higher relaxivity than currently available Gd chelates. The Gd2O3 nanoparticles are also promising for MRI cell tracking. The aim of the present work was to study cell labeling with Gd2O3 nanoparticles and to improve techniques for monitoring hematopoietic stem cell migration by MRI.

    We studied particle uptake in two cell lines; the hematopoietic progenitor cell line Ba/F3 and the monocytic cell line THP-1. Cells were incubated with Gd2O3 nanoparticles as well as superparamagnetic iron oxide particles (SPIOs) for comparison. In addition, it was investigated whether the transfection agent protamine sulfate increased the particle uptake. Treated cells were examined by microscopic techniques, MRI and analyzed for particle content.

    Results showed that particles were intracellular, however in Ba/F3 only sparsely. The relaxation times were shortened with increasing particle concentration. Overall relaxivities, r1 and r2 for Gd2O3 nanoparticles in all cell samples measured were 5.1 ± 0.3 and 14.9 ± 0.7 (s-1mM-1) respectively. Goodness of fit was 0.97 in both cases. Protamine sulfate treatment increased the uptake in both Ba/F3 cells and THP-1 cells.

    Viability of treated cells was not significantly decreased and thus, we conclude that the use of Gd2O3 nanoparticles is suitable for this type of cell labeling by means of detecting and monitoring hematopoietic cells.

  • 116.
    Hedlund, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet.
    Ahrén, Maria
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Gustafsson, Håkan
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Abrikossova, Natalia
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Warntjes, Marcel
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Jönsson, Jan-Ivar
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Medicinsk och fysiologisk kemi.
    Uvdal, Kajsa
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
    Engström, Maria
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet.
    Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement2011Ingår i: International journal of nano medicine, ISSN 1178-2013, Vol. 6, s. 3233-3240Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    As the utility of magnetic resonance imaging (MRI) broadens, the importance of having specific and efficient contrast agents increases and in recent time there has been a huge development in the fields of molecular imaging and intracellular markers. Previous studies have shown that gadolinium oxide (Gd2O3) nanoparticles generate higher relaxivity than currently available Gd chelates: In addition, the Gd2O3 nanoparticles have promising properties for MRI cell tracking. The aim of the present work was to study cell labeling with Gd2O3 nanoparticles in hematopoietic cells and to improve techniques for monitoring hematopoietic stem cell migration by MRI. Particle uptake was studied in two cell lines: the hematopoietic progenitor cell line Ba/F3 and the monocytic cell line THP-1. Cells were incubated with Gd2O3 nanoparticles and it was investigated whether the transfection agent protamine sulfate increased the particle uptake. Treated cells were examined by electron microscopy and MRI, and analyzed for particle content by inductively coupled plasma sector field mass spectrometry. Results showed that particles were intracellular, however, sparsely in Ba/F3. The relaxation times were shortened with increasing particle concentration. Relaxivities, r1 and r2 at 1.5 T and 21°C, for Gd2O3 nanoparticles in different cell samples were 3.6–5.3 s-1 mM-1 and 9.6–17.2 s-1 mM-1, respectively. Protamine sulfate treatment increased the uptake in both Ba/F3 cells and THP-1 cells. However, the increased uptake did not increase the relaxation rate for THP-1 as for Ba/F3, probably due to aggregation and/or saturation effects. Viability of treated cells was not significantly decreased and thus, it was concluded that the use of Gd2O3 nanoparticles is suitable for this type of cell labeling by means of detecting and monitoring hematopoietic cells. In conclusion, Gd2O3 nanoparticles are a promising material to achieve positive intracellular MRI contrast; however, further particle development needs to be performed.

  • 117.
    Hedman, Kristofer
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet.
    Tamas, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Thorax-kärlkliniken i Östergötland.
    Nylander, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Decreased aerobic capacity 4 years after aortic valve replacement in male patients operated upon for chronic aortic regurgitation2012Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 32, nr 3, s. 167-171Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Exercise testing is underutilized in patients with valve disease. We have previously found a low physical work capacity in patients with aortic regurgitation 6 months after aortic valve replacement (AVR). The aim of this study was to evaluate aerobic capacity in patients 4 years after AVR, to study how their peak oxygen uptake (peakVO2) had changed postoperatively over a longer period of time. Twenty-one patients (all men, 52 +/- 13 years) who had previously undergone cardiopulmonary exercise testing (CPET) pre- and 6 months postoperatively underwent maximal exercise testing 49 +/- 15 months postoperatively using an electrically braked bicycle ergometer. Breathing gases were analysed and the patients physical fitness levels categorized according to angstrom strands and Wassermans classifications. Mean peakVO2 was 22.8 +/- 5.1 ml x kg-1 x min-1 at the 49-month follow-up, which was lower than at the 6-month follow-up (25.6 +/- 5.8 ml x kg-1 x min-1, P = 0.001). All but one patient presented with a physical fitness level below average using angstrom strands classification, while 13 patients had a low physical capacity according to Wassermans classification. A significant decrease in peakVO2 was observed from six to 49 months postoperatively, and the decrease was larger than expected from the increased age of the patients. CPET could be helpful in timing aortic valve surgery and for the evaluation of need of physical activity as part of a rehabilitation programme.

  • 118.
    Helin Forsberg,, Lena
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet.
    Tamas, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Nylander, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Preoperative Longitudinal Left Ventricular Function by Tissue Doppler Echocardiography at Rest and During Exercise Is Valuable in Timing of Aortic Valve Surgery in Male Aortic Regurgitation Patients2010Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 23, nr 4, s. 387-395Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The aim of this study was to evaluate if left ventricular (LV) systolic function by tissue Doppler echocardiography at rest and during exercise preoperatively could predict postoperative LV function and thereby be useful in the timing of aortic valve surgery in patients with severe aortic regurgitation. Methods: In 29 patients (median age, 59 years; interquartile range, 39-64 years), echocardiography, tissue Doppler echocardiography, and radionuclide ventriculography were performed preoperatively and postoperatively at rest and during supine bicycle exercise. Results: Preoperative ejection fraction (EF) was 62%. Patients formed two groups, with basal LV peak systolic velocity (PSV) 5.9 cm/s preoperatively as the cutoff value between low and high PSV. Preoperatively, patients with low PSV had lower PSV during exercise (Pandlt;.005), EF during exercise (Pandlt;.05), and atrioventricular plane displacement (AVPD) at rest (Pandlt;.005) and during exercise (P andlt;.05) than those with high PSV. Postoperatively, patients with low PSV had smaller AVPD at rest (P andlt;.05), AVPD during exercise (Pandlt;.01), and PSV during exercise (Pandlt;.01). Conclusion: In patients with chronic aortic regurgitation with EFs and LV dimensions not fulfilling criteria for surgery according to guidelines, preoperative PSV and AVPD at rest and during exercise detected postoperative LV dysfunction.

  • 119. Hernelahti, M
    et al.
    Heinonen, OJ
    Karjalainen, J
    Nylander, Eva
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Börjesson, M
    Sudden cardiac death in young athletes: Time for a Nordic approach in screening?2008Ingår i: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 18, nr 2, s. 132-139Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In 2005, the European Society of Cardiology published recommendations for cardiovascular screening in athletes. Discussion on whether screening is beneficial is ongoing. Recently, the first prospective results on effectiveness of screening in preventing sudden deaths were published from Italy. The results were supportive of screening, but did not provide conclusive evidence. Our suggestion for a Nordic approach on this issue is a directed cardiovascular examination initially involving elite athletes, because this is feasible with respect to the Nordic health care systems and the organization and logistics of elite competitive sports, but also because of the negative aspects of screening large populations. This directed cardiovascular examination would include personal and family history, clinical examination, and electrocardiography (ECG). Further examinations should thereafter be carried out in athletes with suggestive findings in the initial evaluation. The directed cardiovascular examination should be voluntary. It should be conducted at least once, with information on alarming symptoms (syncope, chest pain or dizziness during exercise) and heredity (sudden cardiac death or hereditary heart disease in near relatives) stressed to the athlete as indications for necessary check-ups in the future. The examination would also provide the athlete with an ECG recording, which is valuable as a reference at a later time. © 2007 Blackwell Munksgaard.

  • 120.
    Hjertberg, Hans
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    The use of ethanol as a marker to detect and quantify the absorption of irrigation fluid during transurethral resection of the prostate1996Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    During transurethral resection of the prostate (TURP), the irrigation fluid is often absorbed by the circulatory system and/or the region around the prostate occasionally resulting in severe signs and symptoms. Instant detection and quantification of absorption of irrigation fluid have not been possible earlier. A method involving tagging of the irrigation fluid with ethamol for detection and quantification of absorbed irrigation fluid by measurement of ethanol in expired breath (EB) has been developed.

    The validity of measuring El3 ethanol to detect and quantify absorbed irrigation fluid was studied in 13 patients undergoing TURF. The EB ethanol was compared with three other methods: 1. Isotope tagging of the irrigation fluid and detection of absorbed fluid using a scintillation detector placed over large blood vessels. 2. Measuring changes in serum-sodium every 10 min. 3. Regular interval monitoring (RIM) of the difference between volume used for inigation and volume recovered from patients every 10 min. The method of measming El3 ethanol was found to be highly valid.

    The possibility of detecting absorption and the incidence of absorption using EB ethanol in the clinical routine was studied in 192 patients undergoing TURP. Half of them absorbed irrigation fluid, 25% absorbed more than 400 ml. The proportion of patients absorbing inigationlhlld was the same for both experienced and inexperienced resectionists.

    Clinical assessment of absorption of irrigation fluid was perfonned by the resectionists and the supervising nurses in 118 patients undergoing TURP. Prerequisites for massive absorption were found by the resectionist in 8/9 patients. The resectionist falsely indicated absorption in 22 patients. The nurses conectly indicated 3/9 patients and falsely indicated 4 patients.

    To investigate the method measuring EB ethanol to detect absorption of inigation fluid during general anaesthesia, 20 patients undervent TURP and EB ethanol was compared to the RIM method. There was a good correlation between the methods.

    Elevated pressure in the bladder-prostatic fossa is a prerequisite for absorption of irrigation fluid. Detection and quantification of absorbed irrigation fluid by EB ethanol was used for eompming 102 patients operated on with and without a pressure warning device alarming at 1.5 kPa in the bladder. Using the device reduced both the volume of absorbed irrigation fluid, and the number of patients absorbing irrigation fluid.

    Both ethanol per se and haemodilution by absorbed irrigation fluid may have impacts on the coagulation system. To investigate the influence of absorption of ethanol tagged mannitol on bleeding time, measurements were perl'omed before and after TURP in 57 patients. No difference in bleeding time was found among patients who absorbed irrigation fluid as compared to those who did not.

    In conclusion, measurement of ethanol in EB for detection and qum1tification of absorbed irrigation fluid is a highly valid method when compared to three other methods. Absorption of irrigation fluid was found in 50% of the patients tmdergoing TURP. Clinical assessments of absorption of irrigation fluid are inreliable. EB ethanol can be used in patients dllling general anaesthesia. Using a pressure warning device decreases the volume of absorbed irrigation fluid, a~ well as the number of patients absorbing it. Absorption of etillmol tagged mannitol as irrigation fluid has no influence on bleeding time.

  • 121.
    Hope, T.A.
    et al.
    Department of Radiology, Stanford University, Stanford, CA, United States.
    Markl, M.
    Department of Medical Physics, University Hospital, Albert-Ludwigs-University, Freiburg, Germany.
    Wigström, Lars
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Alley, M.T.
    Department of Radiology, Stanford University, Stanford, CA, United States.
    Miller, D.C.
    Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States.
    Herfkens, R.J.
    Department of Radiology, Stanford University, Stanford, CA, United States, Stanford University, Dept. of Radiology, Lucas MRI/S Center, 1201 Welch Road, Palo Alto, CA 94304, United States.
    Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping2007Ingår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 26, nr 6, s. 1471-1479Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To determine the difference in flow patterns between healthy volunteers and ascending aortic aneurysm patients using time-resolved three-dimensional (3D) phase contrast magnetic resonance velocity (4D-flow) profiling. Materials and Methods: 4D-flow was performed on 19 healthy volunteers and 13 patients with ascending aortic aneurysms. Vector fields placed on 2D planes were visually graded to analyze helical and retrograde flow patterns along the aortic arch. Quantitative analysis of the pulsatile flow was carried out on manually segmented planes. Results: In volunteers, flow progressed as follows: an initial jet of blood skewed toward the anterior right wall of the ascending aorta is reflected posterolaterally toward the inner curvature creating opposing helices, a right-handed helix along the left wall and a left-handed helix along the right wall, retrograde flow occurred in all volunteers along the inner curvature between the location of the two helices. In the aneurysm patients, the helices were larger, retrograde flow occurred earlier and lasted longer. The average velocity decreased between the ascending aorta and the transverse aorta in volunteers (47.9 mm/second decrease, P = 0.023), while in aneurysm patients the velocity increased (145 mm/second increase, P < 0.001). Conclusion: Dilation of the ascending aorta skews normal flow in the ascending aorta, changing retrograde and helical flow patterns. © 2007 Wiley-Liss, Inc.

  • 122.
    Idvall, Ewa
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Omvårdnad. Linköpings universitet, Hälsouniversitetet.
    Berg, Katarina
    Linköpings universitet, Institutionen för medicin och hälsa, Omvårdnad. Linköpings universitet, Hälsouniversitetet.
    Unosson, Mitra
    Linköpings universitet, Institutionen för medicin och hälsa, Omvårdnad. Linköpings universitet, Hälsouniversitetet.
    Brudin, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Nilsson , U
    Örebro University Hospital.
    Assessment of recovery after day surgery using a modified version of quality of recovery-402009Ingår i: ACTA ANAESTHESIOLOGICA SCANDINAVICA, ISSN 0001-5172 , Vol. 53, nr 5, s. 673-677Artikel i tidskrift (Refereegranskat)
  • 123.
    Itoh, Akinobu
    et al.
    Stanford University.
    Stephens, Elizabeth H
    Rice University.
    Ennis, Daniel B
    University of Calif Los Angeles.
    Carlhäll, Carljohan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Bothe, Wolfgang
    Stanford University.
    Nguyen, Tom C
    Stanford University.
    Swanson, Julia C
    Stanford University.
    Miller, D Craig
    Stanford University.
    Ingels, Nei lB
    Palo Alto Medical Fdn.
    Contribution of myocardium overlying the anterolateral papillary muscle to left ventricular deformation2012Ingår i: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 302, nr 1, s. H180-H187Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Itoh A, Stephens EH, Ennis DB, Carlhall CJ, Bothe W, Nguyen TC, Swanson JC, Miller DC, Ingels NB Jr. Contribution of myocardium overlying the anterolateral papillary muscle to left ventricular deformation. Am J Physiol Heart Circ Physiol 302: H180-H187, 2012. First published October 28, 2011; doi:10.1152/ajpheart.00687.2011.-Previous studies of transmural left ventricular (LV) strains suggested that the myocardium overlying the papillary muscle displays decreased deformation relative to the anterior LV free wall or significant regional heterogeneity. These comparisons, however, were made using different hearts. We sought to extend these studies by examining three equatorial LV regions in the same heart during the same heartbeat. Therefore, deformation was analyzed from transmural beadsets placed in the equatorial LV myocardium overlying the anterolateral papillary muscle (PAP), as well as adjacent equatorial LV regions located more anteriorly (ANT) and laterally (LAT). We found that the magnitudes of LAT normal longitudinal and radial strains, as well as major principal strains, were less than ANT, while those of PAP were intermediate. Subepicardial and midwall myofiber angles of LAT, PAP, and ANT were not significantly different, but PAP subendocardial myofiber angles were significantly higher (more longitudinal as opposed to circumferential orientation). Subepicardial and midwall myofiber strains of ANT, PAP, and LAT were not significantly different, but PAP subendocardial myofiber strains were less. Transmural gradients in circumferential and radial normal strains, and major principal strains, were observed in each region. The two main findings of this study were as follows: 1) PAP strains are largely consistent with adjacent LV equatorial free wall regions, and 2) there is a gradient of strains across the anterolateral equatorial left ventricle despite similarities in myofiber angles and strains. These findings point to graduated equatorial LV heterogeneity and suggest that regional differences in myofiber coupling may constitute the basis for such heterogeneity.

  • 124.
    Jackowski, Christian
    et al.
    Universität Zürich, Inst für Rechtsmedizin, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland.
    Warntjes, Marcel
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Berge, Johan
    Rättsmedicinalverket, Rättsmedicinska avdelningen, Artillerigatan 12, 587 58 Linköping.
    Bär, Walter
    Universität Zürich, Inst für Rechtsmedizin, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland.
    Persson, Anders
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Östergötlands Läns Landsting, Diagnostikcentrum, Röntgenkliniken i Linköping. Linköpings universitet, Hälsouniversitetet.
    Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI2011Ingår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. Jan;21, nr 1, s. 70-78Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: To investigate the performance of postmortem magnetic resonance imaging (pmMRI) in identification and characterization of lethal myocardial infarction in a non-invasive manner on human corpses.

    MATERIALS AND METHODS: Before forensic autopsy, 20 human forensic corpses were examined on a 1.5-T system for the presence of myocardial infarction. Short axis, transversal and longitudinal long axis images (T1-weighted; T2-weighted; PD-weighted) were acquired in situ. In subsequent autopsy, the section technique was adapted to short axis images. Histological investigations were conducted to confirm autopsy and/or radiological diagnoses.

    RESULTS: Nineteen myocardial lesions were detected and age staged with pmMRI, of which 13 were histologically confirmed (chronic, subacute and acute). Six lesions interpreted as peracute by pmMRI showed no macroscopic or histological finding. Five of the six peracute lesions correlated well to coronary pathology, and one case displayed a severe hypertrophic alteration.

    CONCLUSION: pmMRI reliably demonstrates chronic, subacute and acute myocardial infarction in situ. In peracute cases pmMRI may display ischemic lesions undetectable at autopsy and routine histology. pmMRI has the potential to substantiate autopsy and to counteract the loss of reliable information on causes of death due to the recent disappearance of the clinical autopsy.

  • 125.
    Jackowski, Christian
    et al.
    Universität Zürich, Inst für Rechtsmedizin, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland.
    Warntjes, Marcel
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Kihlberg, Johan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Östergötlands Läns Landsting, Diagnostikcentrum, Röntgenkliniken i Linköping. Linköpings universitet, Hälsouniversitetet.
    Berge, Johan
    Rättsmedicinalverket, Rättsmedicinska avdelningen, Artillerigatan 12, 587 58 Linköping.
    Thali, Michael J.
    Univ Bern, Inst Forensic Medicine, Ctr Forens Imaging & Virtopsy, CH-3012 Bern, Switzerland.
    Persson, Anders
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Quantitative MRI in Isotropic Spatial Resolution for Forensic Soft Tissue Documentation. Why and How?2011Ingår i: Journal of Forensic Sciences, ISSN 0022-1198, E-ISSN 1556-4029, Vol. 56, nr 1, s. 208-215Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A quantification of T1, T2, and PD in high isotropic resolution was performed on corpses. Isotropic and quantified postmortem magnetic resonance (IQpmMR) enables sophisticated 3D postprocessing, such as reformatting and volume rendering. The body tissues can be characterized by the combination of these three values. The values of T1, T2, and PD were given as coordinates in a T1-T2-PD space where similar tissue voxels formed clusters. Implementing in a volume rendering software enabled color encoding of specific tissues and pathologies in 3D models of the corpse similar to computed tomography, but with distinctively more powerful soft tissue discrimination. From IQpmMR data, any image plane at any contrast weighting may be calculated or 3D color-encoded volume rendering may be carried out. The introduced approach will enable future computer-aided diagnosis that, e.g., checks corpses for a hemorrhage distribution based on the knowledge of its T1-T2-PD vector behavior in a high spatial resolution.

  • 126.
    Janerot Sjöberg, Birgitta
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Winter, Reidar
    Karolinska Universitetssjukhuset Huddinge, Sweden.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Brodin, Lars-Åke
    Kungliga Tekniska Högskolan, Sweden.
    Mobila tekniker för diagnostik vid sängkanten: Mobile bedside diagnostic techniques2008Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 105, nr 43, s. 3025-3030Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [sv]

    Ekokardiografi och mobil myokardskintigrafi är lätta att använda vid sängkanten på akut- och infarktvårdavdelning och kan styra patientflödet.

    Akut myokardischemi kan påvisas som nedsatt regional väggrörlighet och/eller perfusion med både ekokardiigrafi och ektomografi.

    Kvantitativ myokardrörlighetsanalys underlättar och minskar subjektiviteten i ischemidiagnostiken.

  • 127.
    Janerot-Sjöberg, Birgitta
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik. Linköpings universitet, Tekniska högskolan. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Ekberg, Stefan
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.
    Areskog, M.
    Department of Clinical Physiology, Kalmar Regional Hospital.
    Nylander, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Swahn, Eva
    Linköpings universitet, Institutionen för medicin och hälsa, Kardiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Kardiologiska kliniken US.
    Quantitative digital evaluation of myocardial exercise thallium-201 single-photon emission tomography in post-menopausal women1998Ingår i: Clinical Physiology, ISSN 0144-5979, E-ISSN 1365-2281, Vol. 18, nr 3, s. 169-177Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Quantitative computerized analysis of data from myocardial thallium-201 (201Tl) single-photon emission tomography (SPET) may improve the diagnostic accuracy of coronary heart disease. The reference ranges for post-menopausal women are, however, limited and obtained mainly from patients. To compare reference values from healthy post-menopausal women and to improve the quantitative analysis, 20 women (10 patients with coronary heart disease and previous infarction and 10 age-matched healthy volunteers) were examined immediately post exercise and after a delay. A nine-segment 'bull's-eye' model was used for analysis. At visual evaluation, reproducibility was high (93%), no false-positive results were obtained and in 70% of the patients the SPET was interpreted as abnormal. Using reported reference values for quantitative analysis, all the healthy women had an abnormal result. New reference values based on three different methods of 'normalization' were calculated: the relative activity of segment 3 set to 100%, the segment with the highest activity set to 100% and a least-squares method. They all differed significantly from those that had previously been reported. The frequencies of agreement between visual and quantitative analysis were 84-92% and were highest when segment 3 was used as a reference, but in this case only 40% of the patients with coronary heart disease had an abnormal SPET. Using the least-squares method for handling digital information, the SD of the normal values decreased and 90% of the patients with coronary heart disease were accurately diagnosed. These results provide quantitative digital reference values for healthy post-menopausal women. They verify that quantitative analysis is in diagnostic agreement with visual evaluation, stress the need for local verification of reference ranges and suggest a least-square normalization method for the analysis.

  • 128. Jatuzis, D
    et al.
    Zachrisson, Helene
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Blomstrand, C
    Ekholm, S
    Holm, J
    Volkmann, R
    Evaluation of posterior cerebral artery blood flow with transcranial Doppler sonography: value and risk of common carotid artery compression.2000Ingår i: Journal of Clinical Ultrasound, ISSN 0091-2751, E-ISSN 1097-0096, Vol. 28, nr 9, s. 452-460Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: Investigations of the posterior cerebral arteries (PCA) by transcranial Doppler sonography (TCD) may be less reliable than investigations of the anterior part of the circle of Willis. Nevertheless, a true PCA may be identified by manual compression of the proximal common carotid artery (CCA) during TCD. Therefore, we used CCA compression in clinically indicated TCD studies and assessed retrospectively its risks and prospectively its benefits for PCA evaluations.

    METHODS: Using the transtemporal approach, we prospectively assessed flow velocities in posteriorly located blood vessels in 180 consecutive patients before and during CCA compression. The complications of CCA compression were retrospectively reviewed in all 3,383 clinical TCD investigations performed over an 8-year period.

    RESULTS: Decreased flow velocities during ipsilateral CCA compression occurred in 17% of patients. A PCA-like vessel with perfusion from the carotid artery or PCA supply from the carotid circulation was unmasked. Mixed distal PCA support by the posterior communicating artery and proximal PCA could not be shown by TCD. Transient cerebral symptoms occurred in less than 0.4% of the 3,383 retrospectively reviewed TCD investigations; no other adverse effects were seen.

    CONCLUSIONS: TCD without CCA compression may lead to false identification of the PCA. Since transient cerebral symptoms during CCA compression are rare, CCA compression can be used when a clinical TCD investigation of intracranial collateral blood flow compensation is indicated or when the identification of a cerebral artery is uncertain.

  • 129.
    Jennersjo, P E
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Kardiologi. Linköpings universitet, Hälsouniversitetet.
    Wiréhn, Ann-Britt
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Länne, Toste
    Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Nyström, Fredrik
    Linköpings universitet, Institutionen för medicin och hälsa, Internmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Medicincentrum, Endokrin- och magtarmmedicinska kliniken US.
    Östgren, Carl Johan
    Linköpings universitet, Institutionen för medicin och hälsa, Allmänmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i västra Östergötland, Primärvården i västra länsdelen.
    Circadian blood pressure variation in patients with type 2 diabetes - relationship between dipper status and early cardiovascular organ damage2009Ingår i: in DIABETOLOGIA, vol 52, 2009, Vol. 52, s. S430-S430Konferensbidrag (Refereegranskat)
    Abstract [en]

    n/a

  • 130.
    Jennersjö, Pär E.
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Allmänmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i västra Östergötland, Primärvården i västra länsdelen.
    Wijkman, Magnus
    Linköpings universitet, Institutionen för medicin och hälsa, Internmedicin. Linköpings universitet, Hälsouniversitetet.
    Wiréhn, Ann-Britt
    Östergötlands Läns Landsting, Närsjukvården i västra Östergötland, Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland.
    Länne, Toste
    Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Thorax-kärlkliniken i Östergötland.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Nyström, Fredrik H.
    Linköpings universitet, Institutionen för medicin och hälsa, Internmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Endokrin- och magtarmmedicinska kliniken US.
    Östgren, Carl Johan
    Linköpings universitet, Institutionen för medicin och hälsa, Allmänmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i västra Östergötland, Primärvården i västra länsdelen.
    Circadian blood pressure variation in patients with type 2 diabetes - relationship to macro- and microvascular subclinical organ damage2011Ingår i: Primary Care Diabetes, ISSN 1751-9918, E-ISSN 1878-0210, Vol. 5, nr 3, s. 167-173Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aims

    To explore the association between nocturnal blood pressure (BP) dipper status and macro- and microvascular organ damage in type 2 diabetes.

    Methods

    Cross-sectional data from 663 patients with type 2 diabetes, aged 55–66 years, were analysed. Nurses measured office BP and ambulatory BP during 24 h. Individuals with ≥10% difference in nocturnal systolic blood pressure (SBP) relative to daytime values were defined as dippers. Non-dippers were defined as <10% nocturnal decrease in SBP. Estimated glomerular filtration rate (GFR) was calculated and microalbuminuria was measured by albumin:creatinine ratio (ACR). Aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries.

    Results

    We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p = 0.008), lower ACR (p = 0.001) and NT-proBNP (p = 0.001) and increased GFR (p < 0.001).

    Conclusions

    We conclude that diurnal BP variation provides further information about early macro- and microvascular subclinical organ damage that goes beyond standardized office BP measurements in patients with type 2 diabetes.

  • 131.
    Jogestrand, T.
    et al.
    Karolinska universitetssjuk­huset, Huddinge, Stockholm.
    Freden-Lindkvist, J.
    Sahlgrenska universitetssjukhuset, Göteborg.
    Lindqvist, M.
    ­Karolinska universitetssjukhuset, Solna, Stockholm.
    Lundgren, S.
    ­Blekingesjukhuset, Karlskrona.
    Sundby, A.
    ­Norrlands ­universitetssjukhus, Umeå.
    Tillman, Ann-Sofie
    Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Kardiologiska kliniken ViN.
    Zachrisson, Helene
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Equalis kriterier för karotisdiagnostik – under kontinuerlig uppgradering2012Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 109, nr 13, s. 702-703Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    Ultraljudsundersökning av karotisartärerna med så­­ ­kallad duplexteknik har använts i Sverige sedan början av 1980-talet. Equalis expertgrupp för ­fysiologisk kärldia­gnostik har nyligen presen­terat sina rekommendationer för karotisdiagnostik med ultra­ljudsteknik.

  • 132.
    Johansson, Joakim
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
    Bäckryd, Emmanuel
    Linköpings universitet, Institutionen för medicin och hälsa, Rehabiliteringsmedicin. Linköpings universitet, Hälsouniversitetet.
    Granerus, Göran
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Sjöberg, Folke
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Brännskadevård. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Sinnescentrum, Hand- och plastikkirurgiska kliniken US. Östergötlands Läns Landsting, Sinnescentrum, Anestesi- och operationkliniken US.
    Urinary excretion of histamine and methylhistamine after burns2012Ingår i: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 38, nr 7, s. 1005-1009Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The increased vascular permeability seen after burn contribute to morbidity and mortality as it interferes with organ function and the healing process. Large efforts have been made to explore underlying pathophysiological mechanisms that generate increased vascular permeability after burns. Many different substances have been proposed as mediators of which histamine, serotonin and oxygen radicals are claimed most important. However, no specific blocker has convincingly been shown to be clinically effective. Early work has claimed increased histamine plasma-concentrations in humans after burn and data from animal models pointed at histamine as an important mediator. Modern human clinical studies investigating the role of histamine as a mediator of the generalized post burn increase in vascular permeability are lacking. less thanbrgreater than less thanbrgreater thanMethod: We examined histamine turnover by measuring the urinary excretion of histamine and methyl histamine for 48 h after burns in 8 patients (mean total burn surface area 24%). less thanbrgreater than less thanbrgreater thanResults: Over time, in this time frame and compared to healthy controls we found a small increase in the excretion of histamine, but no increase of its metabolite methylhistamine. less thanbrgreater than less thanbrgreater thanConclusion: Our findings do not support that histamine is an important mediator of the increased systemic vascular permeability seen after burn.

  • 133.
    Johansson, K.
    et al.
    n/a.
    Ahn, Henrik Casimir
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Berg, Sören
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Brudin, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Olofsson, Pia
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala. Linköpings universitet, Hälsouniversitetet.
    Mellblom, L.
    n/a.
    Soderholm, Johan D
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala.
    Tholin, M.
    n/a.
    INTESTINAL MICROCIRCULATION, BARRIER FUNCTION AND MORPHOLOGY DURING LOW GRADE IAH/EXPERIMENTAL LAPAROSCOPY IN PIGS2009Ingår i: in ACTA CLINICA BELGICA, vol 64, issue 3, 2009, Vol. 64, nr 3, s. 261-261Konferensbidrag (Refereegranskat)
    Abstract [en]

    n/a

  • 134.
    Jorfeldt, L.
    et al.
    Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Hospital, SE-171 76 Stockholm, Sweden.
    Vedung, T.
    Department of Hand Surgery, South Stockholm General Hospital, SE-118 83 Stockholm, Sweden, Dept. of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Forsström, Elisabeth
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Henriksson, J.
    Dept. of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Influence of leg position and environmental temperature on segmental volume expansion during venous occlusion plethysmography2003Ingår i: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 104, nr 6, s. 599-605Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Blood flow determinations by venous occlusion plethysmography applying the strain-gauge technique are frequently used. A problem with the strain-gauge technique is that the relationship between venous volume and transmural pressure is not linear and, furthermore, changes with the sympathetic tone. The present study tests the hypothesis that these factors lead to a redistribution of venous blood, which may impair the accuracy of the technique. The relative volume expansion rates of four leg segments were studied with the leg in different positions and at disparate temperatures, thereby inducing varying venous pressures and sympathetic tone (n = 6). With elevated leg and relaxed veins (at 50°C), the distal thigh showed a relatively low expansion rate (25.8 ± 4.5 ml·min-1, l-1), whereas values in the calf segments were higher (34.5-39.0ml·min-1·l-1). With lower initial transmural pressure, calf segments can increase their volume much more during occlusion compared with the distal thigh. In a higher transmural pressure region (lowered leg), the difference in compliance between limb segments is less. In this case, compliance and volume expansion rate was higher in the distal thigh (14.2, 13.5 and 22.2ml·min-1·l-1 at 10, 20 and 50°C respectively) than in the calf segments (for the distal calf: 6.4, 7.7 and 16.2 ml·min-1=1-1 respectively). There was a significant interaction (P < 0.001) between temperature and leg position, indicating a higher degree of sympathetic vasoactivity in the calf. It is concluded that blood flow determination by strain-gauge plethysmography is less accurate, due to a potential redistribution of the venous blood. Therefore possible influences of variations in sympathetic tone and venous pressure must be considered even in intra-individual comparisons, especially in interventional studies.

  • 135.
    Jönsson, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk farmakologi.
    Brudin, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Ahlner, Johan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet.
    Hedenmalm, Karin
    Uppsala University, Sweden.
    Eriksson, Anders
    Umeå, University, Sweden.
    Hägg, Staffan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk farmakologi.
    Antipsychotics associated with pulmonary embolism in a Swedish medicolegal autopsy series2008Ingår i: International Clinical Psychopharmacology, ISSN 0268-1315, E-ISSN 1473-5857, Vol. 23, nr 5, s. 263-268Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    To determine the association between fatal pulmonary embolism and use of antipsychotic drugs in a Swedish medicolegal autopsy series. Persons aged 18-65 years and subjected to a medicolegal autopsy in 1992-2005 were selected. On the basis of external cause of death, determined by the forensic pathologist, unnatural deaths (including fatal intoxications) were excluded and participants in whom pulmonary embolism was the cause of death were identified. Use of antipsychotics was based on the results of the postmortem analyses and categorized as use of high-potency first-generation antipsychotics, low-potency first-generation antipsychotics, second-generation antipsychotics or no use of antipsychotics. Logistic regression analyses were performed. Use of antipsychotics was verified in 538 of the 14,439 included participants. Pulmonary embolism was recorded as the cause of death in 279 participants and 33 of these used antipsychotics. Use of low-potency first-generation antipsychotics and second-generation antipsychotics was significantly associated with fatal pulmonary embolism (adjusted odds ratio: 2.39, 95% confidence interval: 1.46-3.92 and 6.91, 95% confidence interval: 3.95-12.10, respectively). Out of 26 participants classified as high-potency first-generation antipsychotic drug users, none had pulmonary embolism as the cause of death. Pulmonary embolism was overrepresented among medicolegal autopsy cases identified as users of low-potency first-generation and second-generation antipsychotics.

  • 136.
    Jönsson, Anna
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk farmakologi.
    Brudin, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Ahlner, Johan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet.
    Hedenmalm, Karin
    Dpt of Clinical Pharmacology, Uppsala universitet. Clinical Trial Unit, Medical Products Agency, Uppsala.
    Eriksson, Anders
    Section of Forensic Medicine, Umeå universitet.
    Hägg, Staffan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk farmakologi.
    Antispychotics Associated with Pulmonary Emboi in a Swedish Medico-Legal Autopsy Series2007Konferensbidrag (Refereegranskat)
  • 137.
    Kajiura, M.
    et al.
    Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, Japan.
    Tanaka, H.
    Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, Japan.
    Borres, M.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Thulesius, O.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    Yamaguchi, H.
    Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, Japan.
    Tamai, H.
    Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, Japan.
    Variant autonomic regulation during active standing in Swedish and Japanese junior high school children2008Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 28, nr 3, s. 174-181Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The present investigation is about cardiovascular responses and relevant autonomic function in Swedish and Japanese pubertal children on active standing using non-invasive continuous beat-to-beat finger arterial pressure (FAP) monitoring and power spectral analysis. Examined were 54 Swedish and 57 Japanese children (13-15 years). FAP and heart rate (HR) was continuously recorded in the supine position and during standing. Supine FAP was significantly higher in Swedish compared with Japanese children (121/62 versus 103/53 mmHg, P < 0.001). Swedish children showed a higher increase in arterial pressure and HR upon uprising, resulting in a higher vasoconstrictor index (5.04 ± 0.22 versus 2.31 ± 0.11 mmHgs-1, P < 0.001, respectively). There were also higher increases in arterial pressure and HR in the following steady state period (1-7min) between the two groups. These differences were also found after adjustment of body weight and height. Frequency domain analysis of HR and arterial pressure variability indicated significantly higher low/high frequency power of HR and low frequency power of arterial pressure. These results suggest that Swedish pubertal children have higher basal blood pressure and enhanced cardiovascular sympathetic responses. These differences in the two cohorts might be caused by genetic factors. © 2008 The Authors Journal compilation © 2008 Scandinavian Society of Clinical Physiology and Nuclear Medicine.

  • 138.
    Karlsson, Jan-Erik
    Linköpings universitet, Institutionen för medicin och vård, Kardiologi. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Unstable coronary artery disease: non-invasive indicators of severity of coronary lesions and the effects of thrombolysis1994Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Non-invasive indicators of severity of coronary lesions and the effects of thrombolysis were evaluated in 205 men, 38 to 70 years of age with unstable coronary aticty disease (CAD)- i.e. unstable angina or non-Q wave myocardial infarction - admitted to the coronary care units in nine hospitals. The patients were randomised to double-blind and placebo-controlled treatment with an intravenous infusion of recombinant tissue-type plasminogen activator (tt-PA) in addition to aspirin, heparin and betablockade. A symptom-limited exercise test was performed before discharge in 190 patients and a second exercise test, combined with thallium-201 SPECT, was performed after one month in 170 patients. Coronary angiography was performed in 199 patients after one month when also exercise echocardiography and 48 hours ambulatory ST-recording were performed in 65 and 95 patients respectively. The non-invasive tests were compared to each other and to coronary angiography in order to elucidate the best method to identify patients with severe coronary lesions -defined as three vessel disease, left main stenosis or proximal left anterior descending artery stenosis as part of two vessel disease.

    Thrombolytic treatment with rt-PA did not reduce the incidence of death, myocardial infarction or urgent revascularisation early or during one year follow-up. Myocardial ischemia, defined as death, myocardial infarction, revascularisation because of refractory angina or signs of ischemia at an exercise test, was reduced by treatment with rt-PA both at discharge, 53%compared to 70% (p=0.02), and after one month, 61% compared to 80% (p=0.005) respectively. No severe side-effects of rt-PA occurred.

    Stepwise multiple regression analysis showed that ST -depression and low maximal work load were the most important exercise variables for identification of severe coronary lesions. Using a combination of these parameters, the sensitivity and specificity for identification of severe coronary lesions were respectively 77% and 70%. More sophisticated methods of evaluating the ECG reaction during exercise were not diagnostically superior to the simple identification of ST-depression of > 0.1 m V.

    In patients with ST -depression at ambulatory monitoring, 79% demonstrated lhe same finding at the exercise test. A "high risk exercise test response" defined as either ST-depression in:?. 3 leads or ST -depression in 1 - 2 leads with a maximal work load below the 60th percentile or a maximal work load below the 30th percentile regardless of the ECG reaction during exercise, occurred in 82%, while ST -depression at ambulatory monitoring was observed only in 41% of the patients with severe coronary lesions (p<O.OOI).

    A combination of thallium-201 SPECT and ECG at exercise testing identified 82% of the patients with severe coronary lesions with a specificity of 63%. Furthermore, thallium-201 SPECT identified more patients with isolated proximal left anterior descending artery stenosis than the exercise test alone.

    Wall motion abnormalities at exercise echocardiography were seen in 53 patients (81 %) at rest and perfusion defects at thallium-201 SPECT in 57 patients (88%) in the rest images. New or worsening of wall motion abnormalities were seen in 55 patients (180 segments) either seated at peak exercise or recumbent after exercise whereas 43 patients (105 segments) had reversible or partially reversible thallium-201 SPECT scintigraphic defects (p=0.02). The segmental agreement between wall motion abnormalities and scintigraphic defects was low (58%). Theadditional value of exercise echocardiography to the exercise test was greatest in patients with one vessel disease.

    Based on the present and other studies, thrombolysis can not be recommended as a routine therapy in unstable CAD. An early exercise test is safe and contributes to the identification of patients with severe coronary lesions who might benefit from revascularisation. Thallium-201SPECT and exercise echocardiography one month after an episode of unstable CAD have additional value to an ordinary exercise test for the identification or exclusion of severe coronary lesions, while ST -recording has no additional value.

  • 139.
    Kihlberg, Johan
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet.
    Fransson, Sven-Göran
    Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Bildmedicinskt centrum, Röntgenkliniken i Linköping.
    Engvall, Jan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Maret, Eva
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Warntjes, Marcel
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Rommel, Franz
    Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Hematologiska kliniken US.
    Ackumulering av överskottsjärn kan bestämmas med MR2009Ingår i: Ackumulering av överskottsjärn kan bestämmas med MR, 2009Konferensbidrag (Refereegranskat)
    Abstract [sv]

    Järnöverskott kan vara toxiskt i kroppen. Järnöverskott ses fr a efter multipla blodtransfusioner vid vissa blodsjukdomar. Internationellt är den vanligaste orsaken thalassemi. Antalet patienter med denna problematik är i Sverige ännu begränsat. Järnöverskott kan leda till allvarlig, svårbehandlad hjärtsvikt man kan behandlas med chelaterande perorala läkemedel och styrs då i allmänhet utifrån ferritin/s. Vår hypotes var att överensstämmelsen mellan järnöverskott och transferrin är låg, att järnöverskott bättre karaktäriseras med MR som också kan differentiera mellan järnöverskott i  hjärta respektive lever.

  • 140.
    Kindberg, Katarina
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Carlhäll, Carljohan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Nguyen, T C
    Stanford University.
    Cheng, A
    Stanford University.
    Langer, F
    Stanford University.
    Rodriguez, F
    Stanford University.
    Daughters, G T
    Stanford University.
    Miller, D C
    Stanford University.
    Jr Ingels, N B
    Stanford University.
    Transmural Strains in the Ovine Left Ventricular Lateral Wall During Diastolic Filling2009Ingår i: JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, ISSN 0148-0731, Vol. 131, nr 6Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Rapid early diastolic left ventricular (LV) filling requires a highly compliant chamber immediately after systole, allowing inflow at low driving pressures. The transmural LV deformations associated with such filling are not completely understood. We sought to characterize regional transmural LV strains during diastole, with focus on early filling, in ovine hearts at 1 week and 8 weeks after myocardial marker implantation. In seven normal sheep hearts, 13 radiopaque markers were inserted to silhouette the LV chamber and a transmural beadset was implanted into the lateral equatorial LV wall to measure transmural strains. Four-dimensional marker dynamics were obtained 1 week and 8 weeks thereafter with biplane videofluoroscopy in closed-chest, anesthetized animals. LV transmural strains in both cardiac and fiber-sheet coordinates were studied from filling onset to the end of early filling (EOEF, 100 ms after filling onset) and at end diastole. At the 8 week study, subepicardial circumferential strain (E-CC) had reached its final value already at EOEF, while longitudinal and radial strains were nearly zero at this time. Subepicardial E-CC and fiber relengthening (E-ff) at EOEF were reduced to 1 compared with 8 weeks after surgery (E-CC:0.02 +/- 0.01 to 0.08 +/- 0.02 and E-ff:0.00 +/- 0.01 to 0.03 +/- 0.01, respectively, both P < 0.05). Subepicardial E-CC during early LV filling was associated primarily with fiber-normal and sheet-normal shears at the 1 week study, but to all three fiber-sheet shears and fiber relengthening at the 8 week study. These changes in LV subepicardial mechanics provide a possible mechanistic basis for regional myocardial lusitropic function, and may add to our understanding of LV myocardial diastolic dysfunction.

  • 141.
    Kindberg, Katarina
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Haraldsson, Henrik
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ingels, Neil B.
    dDepartment of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Myocardial strains from 3D DENSE magnetic resonance imagingManuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    The ability to measure and quantify myocardial motion and deformation provides a useful tool to assist in the diagnosis, prognosis and management of heart disease. The recent development of magnetic resonance imaging methods, such as harmonic phase and displacement encoding with stimulated echoes (DENSE), make detailed non-invasive 3D transmural kinematic analyses of human myocardium possible in the clinic and for research purposes. As data acquisition technologies improve, quantification methods for cardiac kinematics need to be adapted and validated on the new types of data. In the present paper, a previously presented polynomial method for cardiac strain quantification is extended to quantify 3D strains from DENSE magnetic resonance imaging data. The method yields accurate results when validated against an analytical standard, and is applied to in vivo data from a healthy  human heart. The polynomial field is capable of resolving the measured material positions from the in vivo data, and the obtained in vivo strains agree

  • 142.
    Kindberg, Katarina
    et al.
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Haraldsson, Henrik
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Sigfridsson, Andreas
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Engvall, Jan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Ingels, Neil B.
    Stanford University, CA, USA .
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik.
    Karlsson, Matts
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Myocardial strains from 3D displacement encoded magnetic resonance imaging2012Ingår i: BMC Medical Imaging, ISSN 1471-2342, E-ISSN 1471-2342, Vol. 12, nr 9Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background

    The ability to measure and quantify myocardial motion and deformation provides a useful tool to assist in the diagnosis, prognosis and management of heart disease. The recent development of magnetic resonance imaging methods, such as harmonic phase analysis of tagging and displacement encoding with stimulated echoes (DENSE), make detailed non-invasive 3D kinematic analyses of human myocardium possible in the clinic and for research purposes. A robust analysis method is required, however.

    Methods

    We propose to estimate strain using a polynomial function which produces local models of the displacement field obtained with DENSE. Given a specific polynomial order, the model is obtained as the least squares fit of the acquired displacement field. These local models are subsequently used to produce estimates of the full strain tensor.

    Results

    The proposed method is evaluated on a numerical phantom as well as in vivo on a healthy human heart. The evaluation showed that the proposed method produced accurate results and showed low sensitivity to noise in the numerical phantom. The method was also demonstrated in vivo by assessment of the full strain tensor and to resolve transmural strain variations.

    Conclusions

    Strain estimation within a 3D myocardial volume based on polynomial functions yields accurate and robust results when validated on an analytical model. The polynomial field is capable of resolving the measured material positions from the in vivo data, and the obtained in vivo strains values agree with previously reported myocardial strains in normal human hearts.

  • 143.
    Kindberg, Katarina
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Haraldsson, Henrik
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Sakuma, Hajime
    Department of Radiology, Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Temporal 3D Lagrangian strain from 2D slice followed cine DENSE MRI2012Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 32, nr 2, s. 139-144Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A quantitative analysis of myocardial mechanics is fundamental to the understanding of cardiac function, diagnosis of heart disease and assessment of therapeutic intervention. In the clinical situation, where limited scan time often is important, a detailed analysis of the myocardium in a specific region might be more applicable than a full 3D measurement of the entire left ventricle. This paper presents a method to obtain temporal evolutions of transmural 3D Lagrangian strains from two intersecting 2D planes of slice followed cine displacement encoding with stimulated echoes (DENSE) data using a bilinear-cubic polynomial element to resolve strain from the displaced myocardial positions. The method demonstrates accurate results when validated in an analytical model, and has been applied to in vivo data acquired on a 3 T magnetic resonance (MR) system from a healthy volunteer to quantify systolic strains at the anterior-basal region of left ventricular myocardium. The in vivo results agree within experimental accuracy with values reported in the literature.

  • 144.
    Knutsson, Hans
    et al.
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Andersson, Mats
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Borga, Magnus
    Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.
    Wigström, Lars
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Respiratory Arifact Reduction in MRI using Dynamic Deformation Modelling2002Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    This paper presents a novel magnetic resonance imaging (MRI) reconstruction method that will reconstruct an object correctly despite the presence of respiratory-type motions. The basis for the method is the observation that affine deformations of an object will correspond to a different but unique affine coordinate transform of the Fourier representation (k-space) of the object. The resulting sample points will be irregularly distributed prohibiting the use of standard IFFT to reconstruct the object. The object can however be reconstructed through the use of a weighted regularized pseudo inverse. Short computing times are obtained using a novel fast sequential pseudo inverse algorithm.

     

  • 145.
    Kvikliene, Adriana
    et al.
    Institute of Biomedical Engineering, Kaunas University of Technology, K. Donelaicio st. 73, Kaunas LT-3006, Lithuania.
    Jurkonis, Rytis
    Institute of Biomedical Engineering, Kaunas University of Technology, K. Donelaicio st. 73, Kaunas LT-3006, Lithuania.
    Ressner, Marcus
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik.
    Hoff, Lars
    Faculty of Science and Engineering, Vestfold University College, P.O. Box 2243, N-3103 Tønsberg, Norway.
    Jansson, Tomas
    Department of Electrical Measurements, Lund University, P.O. Box 118, SE-221 00, Lund, Sweden.
    Janerot Sjöberg, Birgitta
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Lukosevicius, Arunas
    Institute of Biomedical Engineering, Kaunas University of Technology, K. Donelaicio st. 73, Kaunas LT-3006, Lithuania.
    Ask, Per
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för medicinsk teknik, Fysiologisk mätteknik.
    Modelling of nonlinear effects and the response of ultrasound contrast micro bubbles: simulation and experiment2004Ingår i: Ultrasonics, ISSN 0041-624X, E-ISSN 1874-9968, Vol. 42, nr 01-Sep, s. 301-307Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The propagation of diagnostic ultrasonic imaging pulses in tissue and their interaction with contrast micro bubbles is a very complex physical process, which we assumed to be separable into three stages: pulse propagation in tissue, the interaction of the pulse with the contrast bubble, and the propagation of the scattered echo. The model driven approach is used to gain better knowledge of the complex processes involved. A simplified way of field simulation is chosen due to the complexity of the task and the necessity to estimate comparative contributions of each component of the process. Simulations are targeted at myocardial perfusion estimation. A modified method for spatial superposition of attenuated waves enables simulations of low intensity pulse pressure fields from weakly focused transducers in a nonlinear, attenuating, and liquid-like biological medium. These assumptions enable the use of quasi-linear calculations of the acoustic field. The simulations of acoustic bubble response are carried out with the Rayleigh-Plesset equation with the addition of radiation damping. Theoretical simulations with synthesised and experimentally sampled pulses show that the interaction of the excitation pulses with the contrast bubbles is the main cause of nonlinear scattering, and a 2-3 dB increase of second harmonic amplitude depends on nonlinear distortions of the incident pulse. (C) 2004 Elsevier B.V. All rights reserved.

  • 146.
    Kvitting, John-Peder Escobar
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken. Linköpings universitet, Hälsouniversitetet.
    Dyverfeldt, Petter
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Hälsouniversitetet.
    Carlhäll, Carljohan
    Linköpings universitet, Institutionen för medicin och hälsa, Thoraxkirurgi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Hälsouniversitetet.
    Sigfridsson, Andreas
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Hälsouniversitetet.
    Bolger, Ann F
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Ebbers, Tino
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Hälsouniversitetet.
    Engvall, Jan
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Hälsouniversitetet.
    Magnetresonanstomografi ger unika möjligheter att bedöma blodflödet och dess inverkan på hjärt och kärlsystemet.2009Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 106, s. 1901-1904Artikel i tidskrift (Övrigt vetenskapligt)
  • 147.
    Kvitting, J.P.
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Thorax-kärlkliniken.
    Sigfridsson, A.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Wigström, L.
    Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Bolger, A.F.
    Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Analysis of human myocardial dynamics using virtual markers based on magnetic resonance imaging2010Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 30, nr 1, s. 23-29Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Myocardial dynamics are three-dimensional (3D) and time-varying. Cineradiography of surgically implanted makers in animals or patients is accurate for assessing these events, but this invasive method potentially alters myocardial motion. The aim of the study was to quantify myocardial motion using magnetic resonance imaging (MRI) and hence to provide a non-invasive approach to characterize 3D myocardial dynamics.

    Methods: Myocardial motion was quantified in ten normal volunteers by tracking the Lagrangian motion of individual points (i.e. virtual markers), based on time-resolved 3D phase-contrast MRI data and Fourier tracking. Nine points in the myocardium were tracked over the entire cardiac cycle, allowing a wire frame model to be generated and systolic and diastolic events identified.

    Results: Radius of curvature of the left ventricular (LV) wall was calculated from the virtual markers; the ratio between the anterior–posterior (AP) and septal–lateral (SL) walls in the LV shows an oval shape of the apical short axis plane at end systole (ES) and more circular at end diastole (ED). The AP/SL ratio for the basal plane shows an oval shape at ES and ED. We found that the rotation of the basal plane in ES was less compared to the apical plane [−2·0 ± 2·2 versus 4·1 ± 2·6 degrees (P<0·005)]. The apical plane rotated counter clock wise as viewed from the apex.

    Conclusion: This new non-invasive tool, despite current limitations in temporal and spatial resolution, may provide a comprehensive set of virtual myocardial markers throughout the entire LV without the confounding effects introduced by surgical implantation.

  • 148. Kvitting, JPE
    et al.
    Ebbers, Tino
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Wigström, Lars
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Engvall, Jan
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Bolger, Ann F
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken.
    Olin, CL
    Assessment of the 3-D flow pattern in the sinuses of Valsalva2003Ingår i: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 41, nr 6, s. 437A-437AKonferensbidrag (Övrigt vetenskapligt)
  • 149.
    Lantz, Jonas
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Engvall, Jan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Karlsson, Matts
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Large Eddy Simulation of Aortic Coarctation Before and After Surgery2012Konferensbidrag (Refereegranskat)
  • 150.
    Lantz, Jonas
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Ebbers, Tino
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Engvall, Jan
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Karlsson, Matts
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.
    Validation of Turbulent Kinetic Energy in an Aortic Coarctation Before and After Intervention – MRI vs. CFD2013Ingår i: J Cardiovasc Magn Reson. 2013; 15(Suppl 1): E46, 2013Konferensbidrag (Övrigt vetenskapligt)
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