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  • 119251.
    Örjehag, Erik
    Linköpings universitet, Institutionen för systemteknik, Datorseende.
    Unsupervised Learning for Structure from Motion2021Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Perception of depth, ego-motion and robust keypoints is critical for SLAM andstructure from motion applications. Neural networks have achieved great perfor-mance in perception tasks in recent years. But collecting labeled data for super-vised training is labor intensive and costly. This thesis explores recent methodsin unsupervised training of neural networks that can predict depth, ego-motion,keypoints and do geometric consensus maximization. The benefit of unsuper-vised training is that the networks can learn from raw data collected from thecamera sensor, instead of labeled data. The thesis focuses on training on imagesfrom a monocular camera, where no stereo or LIDAR data is available. The exper-iments compare different techniques for depth and ego-motion prediction fromprevious research, and shows how the techniques can be combined successfully.A keypoint prediction network is evaluated and its performance is comparedwith the ORB detector provided by OpenCV. A geometric consensus network isalso implemented and its performance is compared with the RANSAC algorithmin OpenCV. The consensus maximization network is trained on the output of thekeypoint prediction network. For future work it is suggested that all networkscould be combined and trained jointly to reach a better overall performance. Theresults show (1) which techniques in unsupervised depth prediction are most ef-fective, (2) that the keypoint predicting network outperformed the ORB detector,and (3) that the consensus maximization network was able to classify outlierswith comparable performance to the RANSAC algorithm of OpenCV.

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  • 119252.
    Örjeman, Johanna
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande.
    Hjertstedt, Lina
    Linköpings universitet, Institutionen för beteendevetenskap och lärande.
    Litteratur i undervisningen, en tillgång för elevers lärande?: En litteraturstudie kring litteraturs användning i undervisningen i årskurs F-3.2016Självständigt arbete på grundnivå (högskoleexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    syftet med denna konsumtionsuppsats är att ta reda på vad forskning visar kring litteratur i undervisningen och hur det kan vara en tillgång för elevers lärande. Studien fokuserar på vetenskapliga artiklar med resultat riktat på årskurs F-3.

    Resultatet av denna konsumtionsuppsats har utgångspunkt i15 internationella studier. Dessa har granskats och analyserats och därefter strukturerats i fyraövergripande teman med tillhörande underrubriker. Dessa teman är att arbeta med litteratur i undervisningen, skönlitteraturs effekt på elevers lärande, jämförelse mellan litteraturtyper och lärares roll. Resultatet visar att litteratur bör integreras i stor omfattning i undervisningen i år F-3 för att bidra till elevers lärande. Det visar även på att skönlitteratur och facklitteratur bör få större plats i klassrumssituationer och bli ett komplement till den traditionella läroboken.

    Innehållet i studien kan verksamma lärare ta del av för att få en påminnelse om att litteratur i undervisningen är viktigt och bör integreras i större utsträckning. Vi som snart yrkesverksamma lärare kommer ta inspiration av detta till vår undervisning.

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  • 119253.
    Örjestam, Kristoffer
    Linköpings universitet, Institutionen för kultur och kommunikation.
    Föreställningen om idealkvinnan: Det konstruerade pastorala kvinnoporträttet under frihetstiden2017Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    En undersökning i det kvinnligt konstruerade könet och dess framställning pastorala porträtt under frihetstidens Sverige. Genom en undersökning av den dåtida kontexten och analys av tre kvinnliga porträtt undersöks framställningen av kvinnan som ett ideal.

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  • 119254. Beställ onlineKöp publikationen >>
    Örkenby, Lovisa
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Small non-coding RNA in early fly development: plasticity, interactions and improved bioinformatic tools2023Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    At fertilization, the male and female pronuclei undergo a transformation from germline to pluripotency as they fuse, marking the beginning of Drosophila embryogenesis. As the parental contributions decrease, the zygote takes control of its genome in a process called the maternal-to-zygotic transition (MZT). Several small non-coding RNAs (sncRNAs), a very large and diverse group of RNAs, have regulatory roles during this transition. This includes for example microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs). Regulation by miRNAs mainly occurs through mediating maternal mRNA degradation, while piRNAs operate by repressing transposable elements (TEs) and regulating the nanos-induced embryonic body axis determination.

    In this thesis, the complex and dynamic field of early Drosophila embryogenesis and sncRNAs are put in relation to the included papers. In Paper I, I explored the most stress-sensitive embryonic period and found that stress before the midblastula transition retains maternal miRNAs. These miRNAs impact zygotic gene activation by modulating the boundary factor Elba1, leading to compromised transcription control. Paper III examines the piRNA population during MZT. I find differences of unique piRNA sequences in embryos of different ages but not in target preferences, potentially highlighting the importance of constant repression of certain TEs. Paper II addresses specific difficulties with sncRNA seq data analysis and presents a bioinformatic framework to improve these analyses using a sequence-based strategy.

    This thesis highlights the intricate interplay of sncRNAs in the critical period of early Drosophila embryogenesis and offers insights into their regulatory roles.

    Delarbeten
    1. Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis
    Öppna denna publikation i ny flik eller fönster >>Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis
    Visa övriga...
    2023 (Engelska)Ingår i: Molecular Systems Biology, ISSN 1744-4292, E-ISSN 1744-4292, Vol. 19, nr 5, artikel-id e11148Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Early-life stress can result in life-long effects that impact adult health and disease risk, but little is known about how such programming is established and maintained. Here, we show that such epigenetic memories can be initiated in the Drosophila embryo before the major wave of zygotic transcription, and higher-order chromatin structures are established. An early short heat shock results in elevated levels of maternal miRNA and reduced levels of a subgroup of zygotic genes in stage 5 embryos. Using a Dicer-1 mutant, we show that the stress-induced decrease in one of these genes, the insulator-binding factor Elba1, is dependent on functional miRNA biogenesis. Reduction in Elba1 correlates with the upregulation of early developmental genes and promotes a sustained weakening of heterochromatin in the adult fly as indicated by an increased expression of the PEV w(m4h) reporter. We propose that maternal miRNAs, retained in response to an early embryonic heat shock, shape the subsequent de novo heterochromatin establishment that occurs during early development via direct or indirect regulation of some of the earliest expressed genes, including Elba1.

    Ort, förlag, år, upplaga, sidor
    WILEY, 2023
    Nyckelord
    Drosophila; Elba1; Embryogenesis; miRNA; MZT
    Nationell ämneskategori
    Medicinsk genetik
    Identifikatorer
    urn:nbn:se:liu:diva-193008 (URN)10.15252/msb.202211148 (DOI)000953295100001 ()36938679 (PubMedID)
    Anmärkning

    Funding Agencies|Swedish VR,; Ragnar Soederbergs foundation; Knut Wallenberg foundation

    Tillgänglig från: 2023-04-13 Skapad: 2023-04-13 Senast uppdaterad: 2024-01-08
    2. Seqpac: a framework for sRNA-seq analysis in R using sequence-based counts
    Öppna denna publikation i ny flik eller fönster >>Seqpac: a framework for sRNA-seq analysis in R using sequence-based counts
    Visa övriga...
    2023 (Engelska)Ingår i: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 39, nr 4, artikel-id btad144Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Motivation: Feature-based counting is commonly used in RNA-sequencing (RNA-seq) analyses. Here, sequences must align to target features (like genes or non-coding RNAs) and related sequences with different compositions are counted into the same feature. Consequently, sequence integrity is lost, making results less traceable against raw data.Small RNA (sRNA) often maps to multiple features and shows an incredible diversity in form and function. Therefore, applying feature-based strategies may increase the risk of misinterpretation. We present a strategy for sRNA-seq analysis that preserves the integrity of the raw sequence making the data lineage fully traceable. We have consolidated this strategy into Seqpac: An R package that makes a complete sRNA analysis available on multiple platforms. Using published biological data, we show that Seqpac reveals hidden bias and adds new insights to studies that were previously analyzed using feature-based counting.We have identified limitations in the concurrent analysis of RNA-seq data. We call it the traceability dilemma in alignment-based sequencing strategies. By building a flexible framework that preserves the integrity of the read sequence throughout the analysis, we demonstrate better interpretability in sRNA-seq experiments, which are particularly vulnerable to this problem. Applying similar strategies to other transcriptomic workflows may aid in resolving the replication crisis experienced by many fields that depend on transcriptome analyses.

    Ort, förlag, år, upplaga, sidor
    OXFORD UNIV PRESS, 2023
    Nationell ämneskategori
    Bioinformatik och systembiologi
    Identifikatorer
    urn:nbn:se:liu:diva-193708 (URN)10.1093/bioinformatics/btad144 (DOI)000968866900001 ()36944267 (PubMedID)
    Anmärkning

    Funding Agencies|Swedish Research Council [2015-03141]; Knut and Alice Wallenberg Foundation [2015.0165]; Ragnar Soderberg; Swedish Research Council for Sustainable Development [2020-01042]

    Tillgänglig från: 2023-05-15 Skapad: 2023-05-15 Senast uppdaterad: 2023-10-23
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  • 119255.
    Örkenby, Lovisa
    et al.
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Skog, Signe
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Ekman, Helen
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för molekylär medicin och virologi. Linköpings universitet, Medicinska fakulteten.
    Gozzo, Alessandro
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Örtegren Kugelberg, Unn
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Ramesh, Rashmi
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Magadi, Srivathsa
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Zambanini, Gianluca
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för molekylär medicin och virologi. Linköpings universitet, Medicinska fakulteten.
    Nordin, Anna
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för molekylär medicin och virologi. Linköpings universitet, Medicinska fakulteten.
    Cantù, Claudio
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för molekylär medicin och virologi. Linköpings universitet, Medicinska fakulteten.
    Nätt, Daniel
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Öst, Anita
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis2023Ingår i: Molecular Systems Biology, ISSN 1744-4292, E-ISSN 1744-4292, Vol. 19, nr 5, artikel-id e11148Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Early-life stress can result in life-long effects that impact adult health and disease risk, but little is known about how such programming is established and maintained. Here, we show that such epigenetic memories can be initiated in the Drosophila embryo before the major wave of zygotic transcription, and higher-order chromatin structures are established. An early short heat shock results in elevated levels of maternal miRNA and reduced levels of a subgroup of zygotic genes in stage 5 embryos. Using a Dicer-1 mutant, we show that the stress-induced decrease in one of these genes, the insulator-binding factor Elba1, is dependent on functional miRNA biogenesis. Reduction in Elba1 correlates with the upregulation of early developmental genes and promotes a sustained weakening of heterochromatin in the adult fly as indicated by an increased expression of the PEV w(m4h) reporter. We propose that maternal miRNAs, retained in response to an early embryonic heat shock, shape the subsequent de novo heterochromatin establishment that occurs during early development via direct or indirect regulation of some of the earliest expressed genes, including Elba1.

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  • 119256. Örlyggsson, Johan
    et al.
    Andersson, Rolf
    Svensson, Bo
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för tema, Tema vatten i natur och samhälle.
    Alanine as an end product during fermentation of monosacharides by Clostridium strain P21995Ingår i: Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology, ISSN 0003-6072, E-ISSN 1572-9699, Vol. 68, s. 273-280Artikel i tidskrift (Refereegranskat)
  • 119257.
    Örn, Daniel
    et al.
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Szilassy, Martin
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Dil, Bram
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Gustafsson, Fredrik
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    A Novel Multi-Step Algorithm for Low-Energy Positioning Using GPS2016Ingår i: Fusion 2016, 19th International Conference on Information Fusion: Proceedings, IEEE, 2016, s. 1469-1476Konferensbidrag (Refereegranskat)
    Abstract [en]

    GPS is widely used for localization and tracking, however traditional GPS receivers consume too much energy for many applications. This paper implements and evaluates the performance of a low-energy GPS prototype. The main difference is that a traditional GPS needs to sample signals transmitted by satellites for 30 seconds to estimate its position. Our prototype reduces this time by three orders of magnitude and it can compute positions from only 2 milliseconds of data. We present a new algorithm that increases robustness by filtering on estimated residuals instead of using an altitude database. In addition, we show that our new algorithm works with both fixed and moving targets. The solution consists of (1) a portable device that samples the GPS signal and (2) a server that utilizes Doppler navigation and Coarse Time Navigation to estimate positions. We performed tests in a wide variety of environments and situations. These tests show that our prototype provides a median positioning error of roughly 40 meters even when the GPS receiver is moving at 80 kilometres per hour.

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  • 119258.
    Örn, Markus
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Towards Better Alternator Efficiency2014Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The requirements on vehicle industry are constantly getting stricter, especially when it comes to emissions. At the same time cars, trucks and buses are needed for our way of living. This have forced companies to be as ecient as possible in their way of using fossil fuels for travelling and transport. To increase the eciency companies investigate all possible fuel savings to decrease their carbon footprint as much as possible. One area of savings that is not that obvious to many people is the alternator. Several percent of the total energy used by a vehicle are needed to operate the alternator. With a typical alternator eciency of 70% considerable savings can be achieved.

    This thesis that concern alternator eciency was carried out at Scania in Södertälje, Sweden. The goal of the thesis is to construct a mathematical model of an alternator. The model is supposed to consider all losses in the alternator and together with the output power give an eciency model of the alternator at different speeds and loads. A great part of the project has been dealing with the magnetic losses. The magnetic losses have been modeled as an equivalent circuit with the load angle as a central piece. The equivalent circuit is built up by the fact that the alternator used in the vehicles is a salient pole alternator. The equivalent circuit describes a voltage equation where the voltage drop over the magnetic inductance is described. From that relations between the signals in the alternator and output signals can be written.

    The alternator model is then used together with data recorded from different buses all over the world, this to be able to investigate how the alternator contributes to the fuel consump- tion depending on the way that the buses are driven.

    The result of this thesis is a mathematical model that describes the losses in the alternator for different load cases and speeds. 

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  • 119259.
    Örn, Sara
    Linköpings universitet, Institutionen för systemteknik, Kommunikationssystem. Linköpings universitet, Tekniska högskolan.
    Realistic Multi-Cell Interference Coordination in 4G/LTE2012Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    In the LTE mobile system, all cells use the same set of frequencies. This means that a user could experience interference from other cells. A method that has been studied in order to reduce this interference and thereby increase data rate or system throughput is to coordinate scheduling between cells. Good results of this have been found in different studies. However, the interference is generally assumed to be known. Studies using estimated interference and simulating more than one cluster of cells have found almost no gain.

    This thesis will focus on how to use information from coordinated scheduling and other traffic estimates to do better interference estimation and link adaption. The suggested method is to coordinate larger clusters and use the coordination information, as well as estimates of which cells will be transmitting, to make estimates of interference from other cells. The additional information from interference estimation is used in the link adaptation. Limitations in bandwidth of the backhaul needed to send data between cells are considered, as well as the delay it may introduce. A limitation of the scope is that MIMO or HetNet scenarios have not been simulated.

    The suggested method for interference estimation and link adaptation have been implemented and simulated in a system simulator. The method gives a less biased estimate of SINR, but there are no gains in user bit rate. The lesser bias is since the method is better at predicting high SINR than the base estimate is. The lack of gains regarding user bit rate may result from the fact that in the studied scenarios, users where not able to make use of the higher estimated SINR since the base estimate is already high.

    The conclusion is that the method might be useful in scenarios where there are not full load, but the users either have bad channel quality or are able to make use of very high SINR. Such scenarios could be HetNet or MIMO scenarios, respectively.

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  • 119260.
    Örnberg Berglund, Therese
    Linköpings universitet, Institutionen för kultur och kommunikation, Avdelningen för moderna språk. Linköpings universitet, Filosofiska fakulteten.
    Text-based chat and language learning: opportunities and challenges2013Ingår i: Språk i undervisning: rapport från ASLA:s vårsymposium, Linköping, 11-12 maj, 2012 / [ed] Christina Rosén, Per Simfors, Ann-Kari Sundberg, Uppsala: ASLA (Institutionen för Nordiska språk, Uppsala universitet) , 2013, s. 139-149Kapitel i bok, del av antologi (Övrigt vetenskapligt)
    Abstract [en]

    The aim of the current article is to discuss opportunities and challenges with employing text-based interaction in the language classroom. These issues are addressed in relation to empirical data from a Swedish upper secoondary school, where students of English interact with a teacher (the researcher) in instant messaging. In order to gain a detailed picture of the interactional processes, data from chat logs are complemented with screen recordings, keystroke logging data and data from eye tracking. It should be noted that the current article cannot give a comprehensive account of all relevant phenomena and previous research, but rather some identified pattems will be highlighted and discussed.

  • 119261.
    Örnberg, Dennis
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik.
    Comparison and implementation of graph visualization algorithms using JavaFX2016Självständigt arbete på grundnivå (högskoleexamen), 10,5 poäng / 16 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Graph drawing is an important area in computer science and it has many different application areas. For example, graphs can be used to visualize structures like networks and databases. When the graphs are really big, however, it becomes difficult to draw them so that the user can get a good overview of the whole graph and all of its data. There exist a number of different algorithms that can be used to draw graphs, but they have a lot of differences. The goal of this report was to find an algorithm that produces graphs of satisfying quality in little time for the purpose of ontology engineering, and implement it using a platform that visualizes the graph using JavaFX. It is supposed to work on a visualization table with a touch display. A list of criteria for both the algorithm and the application was made to ensure that the final result would be satisfactory. A comparison between four well-known graph visualization algorithms was made and “GEM” was found to be the best suited algorithm for visualizing big graphs. The two platforms Gephi and Prefux were introduced and compared to each other, and the decision was made to implement the algorithm in Prefux since it has support for JavaFX. The algorithm was implemented and evaluated, it was found to produce visually pleasing graphs within a reasonable time frame. A modified version of the algorithm called GEM-2 was also introduced, implemented and evaluated. With GEM-2, the user can pick a specific number of levels to be expanded at first, additional levels can then be expanded by hand. This greatly improves the performance when there is no need to expand the whole graph at once, however, it also increases the amount of edge crossings which makes the graph less visually pleasing.

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  • 119262.
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Tekniska högskolan.
    Entrepreneurial actors between two systems of norms - Profound and professional quality knowledge in Swedish health care2011Konferensbidrag (Övrigt vetenskapligt)
  • 119263.
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Tekniska högskolan.
    Kvalitetsbegreppet i lagstiftningen inom den mänskliga sektorn: - en översikt2013Rapport (Övrig (populärvetenskap, debatt, mm))
    Abstract [sv]

    Denna undersökning behandlar hur olika kvalitetsaspekter i några utvalda sektorslagar förhåller sig till varandra inom hälso- och sjukvård, polis- och kriminalvård, utbildning samt vissa kommunala lagar. Alla befinner sig i den s.k. mänskliga sektorn av offentlig verksamhet. Den bakomliggande orsaken till detta är att Innovationsrådet vill fördjupa kunskapen om hur begreppet kvalitet definieras och används i svensk lagstiftning och i förarbetena till vissa lagar. Undersökningen strävar inte efter att generera någon legaldefinition av begreppet kvalitet.

    Kvalitetsbegreppet delas in i aspekterna; struktur, process och resultat i en analysmodell i form av en matris som även tar hänsyn till personal och medborgarperspektiv. Strukturkvalitet speglar förutsättningarna för eller inflödet i en verksamhet, processkvalitet belyser de aktiviteter som görs i verksamheten och resultatkvalitet återger prestationerna och effekterna av verksamheten. Med hjälp av analysmodellen skapas ett mönster över vilka aspekter som tydligast framträder i lagarna och förarbeten samt vilket perspektiv som är mest påtagligt i respektive lag. Genom analysmodellen har en överblick över varje sektor kunnat ges.

    Undersökningen är en dokumentstudie och baseras på lagtexter med relaterade propositioner samt statliga utredningar. De utvalda lagarna återfinns i bilaga 1. I analysen av materialet har först kvantitativa sökningar gjort på kvalitet och relaterade begrepp såsom kvalitetssäkring, kvalitetsgranskning, kvalitetskontroll samt kvalitetsutvärdering för att få en bild av om kvalitet är ett återkommande begrepp eller inte. Därefter har en granskning och tolkning gjorts för att utreda ur vilka aspekter som kvalitet beskrivs, samt vilket perspektiv som väger tyngst i skrivningar i lagen och dess förarbeten.

    Varje sektor är resultatredovisad för sig i särskilda avsnitt. Resultaten visar att kvalitetsbegreppet inom hälso- och sjukvården är frekvent förekommande ur aspekterna struktur och resultat, medan resultatkvalitet överlämnats till den autonoma medicinska professionen att definiera. I utbildningssektorn tycks förhållandet vara det motsatta där resultatkvalitet i form av måluppfyllelse är det centrala och betonas starkt även kvalitet i termer av struktur och process förekommer. Även i denna sektor lyfter lagstiftaren fram autonomi och egenkontroll i avseende på utbildning och forskning när det gäller att definiera vad som är god kvalitet i vetenskapliga processer och resultat.

    Inom socialtjänsten pågår ett arbete som syftar till att ta fram kvalitetsindikatorer ur olika aspekter inspirerat av hälso- och sjukvården. Idag är begreppet kvalitet tydligast uttryckt i socialtjänstlagen när det gäller aspekterna struktur och process i ett personalperspektiv. Även inom polis och kriminalvård tycks kvalitetsbegreppet öka i betydelse även i lagtexterna, där struktur- och processaspekter framkommer i kriminalvårdens nya fängelse- och häkteslagstftningen. I polislagen lyser dock begreppet kvalitet med sin frånvaro, vilket i sig inte hindrar att krav ställs på kvalitet genom andra kanaler.

    Undersökningen avslutas med en diskussion utifrån de sektorsvisa resultaten om behov av ständigt återkommande omprövningar av hur begreppet ska användas i lagen och avvägningar om risken för cementering av verksamheter å ena sida och rättsäkerhet samt tydlighet å den andra.

    Ladda ner fulltext (pdf)
    Kvalitetsbegreppet i lagstiftningen inom den mänskliga sektorn
  • 119264.
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Mapping via Time-Geography to Elucidate Institutional, Economic and Political Change2012Ingår i: Proceedings of 15th Uddevalla Symposium,2012, Entrepreneurship and Innovation Networks / [ed] Iréne Bernhard, Bohus: Ale Tryckteam , 2012, s. 1-10Konferensbidrag (Refereegranskat)
    Abstract [en]

    Change has always been an issue for studies in politics and economics. However, there are few systematic treatments of institutions. This paper exemplifies how institutions (i.e., rules, norms and conventions) relate to the time-geography concepts of constraints, which affect different agents, policy-making, as well as economic performance.This paper seeks to advance the current discussion and sets some groundwork for further elaboration on economic and political change from an ontological perspective based in time-geography. It offers an initial exploration of the analysis of institutional change by a conceptualization of constraints in time-geography.The contribution of this study lies in the fact that insights from a time-geography approach have the ability to make the evolutionary perspective more coherent in empirically-related works when grading and ordering institutions of relevance concerning economic and political evolvement.

    Ladda ner fulltext (pdf)
    Mapping via Time-geography to Elucidate Institutional, Economic, and Political Change
  • 119265.
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Tekniska högskolan.
    Marknadsskapande, valfrihet och e-hälsa i sjukvården: Utkast till avhandlingsdesign (lic.)2010Konferensbidrag (Övrigt vetenskapligt)
  • 119266. Beställ onlineKöp publikationen >>
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Mellan kunskap och politik: Kvalitetssystem och offentlig kunskapsstyrning i hälso- och sjukvården2016Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [sv]

    Syftet med den här avhandlingen är att undersöka utvecklingen av kvalitetssystem i hälso- och sjukvården ur ett historiskt-institutionellt perspektiv utifrån fallstudier och konceptuella analyser. Särskilt analyseras implikationer av utvecklingen med avseende på relationen mellan den medicinska professionen och det politiskt administrativa systemet samt konsekvenser för den politiska styrningen av sjukvården.

    Studien visar att medicinska kvalitetssystem och därmed även den medicinska professionen bäddats in i den politiska styrningen i takt med att ambitionerna mot en offentlig kunskapsstyrning tilltagit. Den visar även att hälso- och sjukvårdens kvalitetsregister i olika faser av sin utveckling har påverkats av politiska ideologier, managementidéer och idéer om transparens. Öppna jämförelser som en oavsiktlig konsekvens av kvalitetsregisteranvändningen förstärker dessutom tendensen mot en offentlig kunskapsstyrning.

    Av studien framgår också att den offentliga kunskapsstyrningen utmanar föreställningen om demokratiidealet om upplyst förståelse. Den ökade fokuseringen på kunskapsstyrning inom hälso- och sjukvården gör det relevant att ställa frågan vem som styr vem i svensk hälso- och sjukvård, vilket i sig är en fråga om demokrati och legitimitet.

    Delarbeten
    1. Explaining Quality Management in the Danish and Swedish Public Health Sectors: Unintended Learning and Deliberate Co-Optation
    Öppna denna publikation i ny flik eller fönster >>Explaining Quality Management in the Danish and Swedish Public Health Sectors: Unintended Learning and Deliberate Co-Optation
    2016 (Engelska)Ingår i: International Journal of Public Administration, ISSN 0190-0692, E-ISSN 1532-4265, Vol. 39, nr 12, s. 963-975Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    This article examines the development of diverse quality systems in the otherwise quite similar Danish and Swedish public health sectors. After decades of numerous piecemeal medical and managerial quality development programs in both countries, a nationwide mandatory accreditation system was introduced in the Danish health services in 2009. Nationwide quality indicator projects are also found in Sweden, but there has been political attempt to introduce a compulsory system. This article seeks to explain this difference. It argues, first, that resistance from the medical professions blocked the introduction of compulsory, nationwide quality systems in both countries for decades. Second, the implementation of the Danish accreditation system was triggered by a combination of unintended policy learning produced by local reforms in two counties and of the Ministry of Health’s carefully orchestrated policy process that served to co-opt critical voices in the medical profession.

    Ort, förlag, år, upplaga, sidor
    Routledge, 2016
    Nyckelord
    Historical institutionalism; path dependency; policy learning; quality managment systems
    Nationell ämneskategori
    Studier av offentlig förvaltning
    Identifikatorer
    urn:nbn:se:liu:diva-128223 (URN)10.1080/01900692.2015.1064959 (DOI)2-s2.0-84958530409 (Scopus ID)
    Tillgänglig från: 2016-05-23 Skapad: 2016-05-23 Senast uppdaterad: 2017-11-30Bibliografiskt granskad
    2. What frames Quality Registers in Swedish Health Care: an institutional approach
    Öppna denna publikation i ny flik eller fönster >>What frames Quality Registers in Swedish Health Care: an institutional approach
    2011 (Engelska)Ingår i: Proceedings from 14th Uddevalla Symposium, 2011 Entrepreneurial Knowledge, Technology and Transformation of Regions / [ed] Iréne Bernhard, Linköping: Linköping University Electronic Press, 2011, s. 1-19Konferensbidrag, Publicerat paper (Övrigt vetenskapligt)
    Abstract [en]

    Quality issues strike the classical conflict in a democratic health-care deliverysystem of different interests among the politicians, the medical profession andpublic officials. This cannot be studied as a cut-off whiz. Quality registers havedeveloped over the past 40 years. Therefore, this paper puts the innovation ofquality registers in an institutional perspective. Two things are essential in thispaper. First, this paper reviews the emergence of quality registers in Swedish healthcare as an effect of institutional arrangements. Second, it analyses the interactionof diverse factors in different institutional settings and logics. The relevant data forthe study was collected from official/unofficial policy documents and key actorinterviews.The empirical findings show that three different waves of development can betraced in history that has highly affected the development of quality registers. Italso shows that medical quality is framed and determined by physicians in line withprofessional knowledge and by the primary institutional logic of quality in medicalcare. However, organisational quality in health care is framed by the logic ofpublic equity of access based on a third party payer and the logic of managerialcontrol. These two paths of quality developments are now federating in aninstitutional logic of transparency. The contribution of this paper is importantbecause it produces insights in different institutional logics, which frames the riseof the two quality paths and the problems they have to face in order to merge. It also enhances the existing knowledge that institutions matter.

    Ort, förlag, år, upplaga, sidor
    Linköping: Linköping University Electronic Press, 2011
    Serie
    Research Reports 2011:05 University West, ISSN 1653-7831 ; 2011:05
    Nyckelord
    health care, institutional change, quality, innovation
    Nationell ämneskategori
    Studier av offentlig förvaltning
    Identifikatorer
    urn:nbn:se:liu:diva-88746 (URN)978-91-977943-2-9 (ISBN)
    Konferens
    14th Uddevalla Symposium, 2011 Entrepreneurial Knowledge, Technology and Transformation of Regions, June 16-18, Bergamo, Italy
    Tillgänglig från: 2013-02-19 Skapad: 2013-02-18 Senast uppdaterad: 2016-08-31Bibliografiskt granskad
    3. Path Dependence on New Roads. Institutional Development of Quality Registers
    Öppna denna publikation i ny flik eller fönster >>Path Dependence on New Roads. Institutional Development of Quality Registers
    2014 (Engelska)Ingår i: Offentlig Förvaltning. Scandinavian Journal of Public Administration, ISSN 2000-8058, E-ISSN 2001-3310, Vol. 18, nr 2, s. 3-22Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    When explaining social development and changes in public administration, institutional changeis a typical focus. Institutional analysis can combine the analyses of changes on the basis offormal legal and informal arrangements; it commonly shows that institutions lead to inertiawhere changes over time are concerned. Political aims are a guide to how organizations aredesigned and governed. When goals and earlier decisions clearly guide change, path dependenceis a fundamental concept when explaining change. However, this analysis shows how andwhen quality registers appeared as an answer to changes in institutional arrangements in Swedishpublic healthcare. Through three phases, cumulative processes have been visible and theprocesses have been followed by an improved and increased usage of quality registers andother quality systems. This analysis shows that institutional development can be pathdependentin relation to methods and means. Despite changing goals over time, quality registersas a policy tool have been path-dependent and stayed firm. Thus, it is important to see alsoorganisational methods as a development path that can be used to implement even new policyaims.

    Ort, förlag, år, upplaga, sidor
    Förlag Göteborgs Universitet, 2014
    Nyckelord
    Institutional change, quality registers, public governance, path dependence, time
    Nationell ämneskategori
    Studier av offentlig förvaltning
    Identifikatorer
    urn:nbn:se:liu:diva-114514 (URN)
    Tillgänglig från: 2015-02-25 Skapad: 2015-02-25 Senast uppdaterad: 2018-06-15Bibliografiskt granskad
    4. Policymaking through healthcare registries in Sweden
    Öppna denna publikation i ny flik eller fönster >>Policymaking through healthcare registries in Sweden
    2018 (Engelska)Ingår i: Health Promotion International, ISSN 0957-4824, E-ISSN 1460-2245, Vol. 33, nr 2, s. 356-365Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Healthcare registries, otherwise known in Sweden as national quality registries (NQRs), have progressed from being a patient-focused system supporting medical results to become the basis of a health policy steering instrument called regional comparisons (RCs). This article seeks to explain RCs as an unintended consequence of the NQR development, by utilizing the concepts of policy entrepreneurs and streams of impact: the problem stream (problem perceived), the policy stream (what is valid), and the political stream (governmental objectives). The empirical contribution lies in insights on how the RCs have developed as an unintended consequence of entrepreneurial deliberate action in the process of creating NQRs. These findings are based on documents, interviews, and previous research in the social sciences. The article also argues for a critical understanding of public knowledge management (PKM) related to experiences in the development of NQRs regarding how to use knowledge in healthcare government. This article highlights how knowledge generated in quality systems based on registries could imply a stronger role for authorities in exerting control over the medical profession. It also discusses the potential use of research evidence on NQRs as a base for more efficient policymaking.

    Ort, förlag, år, upplaga, sidor
    Oxford University Press, 2018
    Nyckelord
    quality registries, stream coupling, policy entrepreneurs, public knowledge management
    Nationell ämneskategori
    Statsvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-131037 (URN)10.1093/heapro/daw064 (DOI)000429490000018 ()27594141 (PubMedID)
    Tillgänglig från: 2016-09-06 Skapad: 2016-09-06 Senast uppdaterad: 2018-04-26Bibliografiskt granskad
    5. Public quality – for whom and how?: Integrating public core values with quality management
    Öppna denna publikation i ny flik eller fönster >>Public quality – for whom and how?: Integrating public core values with quality management
    2017 (Engelska)Ingår i: Total Quality Management and Business Excellence, ISSN 1478-3363, E-ISSN 1478-3371, Vol. 28, nr 3-4, s. 379-389Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Quality management (QM) plays an important role in public organisations’ efforts to create better access to, and effectiveness of, specific services. When transferring QM models from market-based firms to public services provided by public organisations, several basic contrasts and even contradictions must be addressed. Core values of the public sector differ from those of the private sector, but what are the consequences of this distinction? In this article we discuss the importance of four central arguments on public services: rights and access have to be considered; equality is an important facet of public services; coerciveness is a unique feature of public services; and legitimacy can be improved by high-quality services. These arguments have not been discussed explicitly in the context of QM. Adding these central aspects of public services to the QM field could generate more sustainable ways for developing quality and QM in public services in particular and the public sector in general.

    Ort, förlag, år, upplaga, sidor
    Routledge, 2017
    Nyckelord
    public sector; customer; citizen; quality management
    Nationell ämneskategori
    Studier av offentlig förvaltning
    Identifikatorer
    urn:nbn:se:liu:diva-128224 (URN)10.1080/14783363.2015.1087841 (DOI)000397039800010 ()2-s2.0-84945236799 (Scopus ID)
    Tillgänglig från: 2016-05-23 Skapad: 2016-05-23 Senast uppdaterad: 2022-09-13Bibliografiskt granskad
    Ladda ner fulltext (pdf)
    Mellan kunskap och politik: Kvalitetssystem och offentlig kunskapsstyrning i hälso- och sjukvården
    Ladda ner (pdf)
    omslag
    Ladda ner (jpg)
    presentationsbild
  • 119267.
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Policymaking through healthcare registries in Sweden2018Ingår i: Health Promotion International, ISSN 0957-4824, E-ISSN 1460-2245, Vol. 33, nr 2, s. 356-365Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Healthcare registries, otherwise known in Sweden as national quality registries (NQRs), have progressed from being a patient-focused system supporting medical results to become the basis of a health policy steering instrument called regional comparisons (RCs). This article seeks to explain RCs as an unintended consequence of the NQR development, by utilizing the concepts of policy entrepreneurs and streams of impact: the problem stream (problem perceived), the policy stream (what is valid), and the political stream (governmental objectives). The empirical contribution lies in insights on how the RCs have developed as an unintended consequence of entrepreneurial deliberate action in the process of creating NQRs. These findings are based on documents, interviews, and previous research in the social sciences. The article also argues for a critical understanding of public knowledge management (PKM) related to experiences in the development of NQRs regarding how to use knowledge in healthcare government. This article highlights how knowledge generated in quality systems based on registries could imply a stronger role for authorities in exerting control over the medical profession. It also discusses the potential use of research evidence on NQRs as a base for more efficient policymaking.

  • 119268.
    Örnerheim, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    What frames Quality Registers in Swedish Health Care: an institutional approach2011Ingår i: Proceedings from 14th Uddevalla Symposium, 2011 Entrepreneurial Knowledge, Technology and Transformation of Regions / [ed] Iréne Bernhard, Linköping: Linköping University Electronic Press, 2011, s. 1-19Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    Quality issues strike the classical conflict in a democratic health-care deliverysystem of different interests among the politicians, the medical profession andpublic officials. This cannot be studied as a cut-off whiz. Quality registers havedeveloped over the past 40 years. Therefore, this paper puts the innovation ofquality registers in an institutional perspective. Two things are essential in thispaper. First, this paper reviews the emergence of quality registers in Swedish healthcare as an effect of institutional arrangements. Second, it analyses the interactionof diverse factors in different institutional settings and logics. The relevant data forthe study was collected from official/unofficial policy documents and key actorinterviews.The empirical findings show that three different waves of development can betraced in history that has highly affected the development of quality registers. Italso shows that medical quality is framed and determined by physicians in line withprofessional knowledge and by the primary institutional logic of quality in medicalcare. However, organisational quality in health care is framed by the logic ofpublic equity of access based on a third party payer and the logic of managerialcontrol. These two paths of quality developments are now federating in aninstitutional logic of transparency. The contribution of this paper is importantbecause it produces insights in different institutional logics, which frames the riseof the two quality paths and the problems they have to face in order to merge. It also enhances the existing knowledge that institutions matter.

    Ladda ner fulltext (pdf)
    What Frames Quality Registers in Swedish Health Care
  • 119269.
    Örnerheim, Mattias
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Elg, Mattias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Logistik- och kvalitetsutveckling. Linköpings universitet, Tekniska fakulteten.
    Implementering i vården: En kunskapsöversikt om beslutsnivåer och professionsperspektiv2018Rapport (Övrigt vetenskapligt)
    Abstract [sv]

    Hälso- och sjukvården liksom socialtjänsten är under ständig förändring – medicinska framsteg skapar nya möjligheter till behandling samtidigt som behoven av hälso- och sjukvård och socialtjänst ökar i takt med att allt fler lever längre med kroniska sjukdomar. Socialtjänsten kommer att behöva stödja fler med långvariga och komplexa behov, vilket band annat kommer att ställa krav på ändrade arbetssätt. En fortsatt utveckling i vården och omsorgen är viktigt för att i dag och i framtiden kunna tillhandahålla en god vård och omsorg som patienter och brukare känner förtroende för.Samtidigt finns tecken på att utvecklingen och lärandet inte sker i den omfattning som behövs. I olika analyser har Vårdanalys genom åren visat att lärandet mellan olika verksamheter och huvudmän är begränsat. Orsakerna bakom det är flera.Hösten 2017 initierade vi ett forskningsuppdrag med ambitionen att utifrån litteraturen identifiera övergripande utmaningar när det gäller implementering i hälso- och sjukvården och socialtjänsten. Vi gav professor Mattias Elg och postdoktor Mattias Örnerheim vid institutionen för ekonomisk och industriell utveckling (IEI), Linköpings universitet, uppdraget att presentera en kunskapsöversikt på detta tema.Deras översikt har varit ett värdefullt bidrag till Vårdanalys arbeten under 2017 och 2018 som på olika sätt analyserat utvecklingsarbete och deras förutsättningar att bidra till långsiktig utveckling. Det är vår förhoppning att den här promemorian kan tjäna som ett kunskapsunderlag i den fortsatta diskussionen om hur vi kan skapa bättre förutsättningar till lärande och utveckling i vården och omsorgen.Den här promemorian är författarnas redovisning av forskningsuppdraget i sin helhet och de står själva för innehållet.

    Ladda ner fulltext (pdf)
    I mplementering i vården : En kunskapsöversikt om beslutsnivåer och professionsperspektiv
    Ladda ner (png)
    presentationsbild
  • 119270.
    Örnerheim, Mattias
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Triantafilloub, Peter
    Department of Society and Globalisation, Roskilde University,Roskilde, Denmark.
    Explaining Quality Management in the Danish and Swedish Public Health Sectors: Unintended Learning and Deliberate Co-Optation2016Ingår i: International Journal of Public Administration, ISSN 0190-0692, E-ISSN 1532-4265, Vol. 39, nr 12, s. 963-975Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This article examines the development of diverse quality systems in the otherwise quite similar Danish and Swedish public health sectors. After decades of numerous piecemeal medical and managerial quality development programs in both countries, a nationwide mandatory accreditation system was introduced in the Danish health services in 2009. Nationwide quality indicator projects are also found in Sweden, but there has been political attempt to introduce a compulsory system. This article seeks to explain this difference. It argues, first, that resistance from the medical professions blocked the introduction of compulsory, nationwide quality systems in both countries for decades. Second, the implementation of the Danish accreditation system was triggered by a combination of unintended policy learning produced by local reforms in two counties and of the Ministry of Health’s carefully orchestrated policy process that served to co-opt critical voices in the medical profession.

    Ladda ner fulltext (pdf)
    fulltext
  • 119271.
    Örnerheim, Mattias
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Wihlborg, Elin
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Statsvetenskap. Linköpings universitet, Filosofiska fakulteten.
    Path Dependence on New Roads. Institutional Development of Quality Registers2014Ingår i: Offentlig Förvaltning. Scandinavian Journal of Public Administration, ISSN 2000-8058, E-ISSN 2001-3310, Vol. 18, nr 2, s. 3-22Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    When explaining social development and changes in public administration, institutional changeis a typical focus. Institutional analysis can combine the analyses of changes on the basis offormal legal and informal arrangements; it commonly shows that institutions lead to inertiawhere changes over time are concerned. Political aims are a guide to how organizations aredesigned and governed. When goals and earlier decisions clearly guide change, path dependenceis a fundamental concept when explaining change. However, this analysis shows how andwhen quality registers appeared as an answer to changes in institutional arrangements in Swedishpublic healthcare. Through three phases, cumulative processes have been visible and theprocesses have been followed by an improved and increased usage of quality registers andother quality systems. This analysis shows that institutional development can be pathdependentin relation to methods and means. Despite changing goals over time, quality registersas a policy tool have been path-dependent and stayed firm. Thus, it is important to see alsoorganisational methods as a development path that can be used to implement even new policyaims.

    Ladda ner fulltext (pdf)
    fulltext
  • 119272.
    Örnhag, Marcus Valtonen
    et al.
    Lund Univ, Sweden.
    Persson, Patrik
    Lund Univ, Sweden.
    Wadenbäck, Mårten
    Linköpings universitet, Institutionen för systemteknik, Datorseende. Linköpings universitet, Tekniska fakulteten.
    Åström, Kalle
    Lund Univ, Sweden.
    Heyden, Anders
    Lund Univ, Sweden.
    Minimal Solvers for Indoor UAV Positioning2021Ingår i: 2020 25TH INTERNATIONAL CONFERENCE ON PATTERN RECOGNITION (ICPR), IEEE COMPUTER SOC , 2021, s. 1136-1143Konferensbidrag (Refereegranskat)
    Abstract [en]

    In this paper we consider a collection of relative pose problems which arise naturally in applications for visual indoor navigation using unmanned aerial vehicles (UAVs). We focus on cases where additional information from an onboard IMU is available and thus provides a partial extrinsic calibration through the gravitational vector. The solvers are designed for a partially calibrated camera, for a variety of realistic indoor scenarios, which makes it possible to navigate using images of the ground floor. Current state-of-the-art solvers use more general assumptions, such as using arbitrary planar structures; however, these solvers do not yield adequate reconstructions for real scenes, nor do they perform fast enough to be incorporated in real-time systems. We show that the proposed solvers enjoy better numerical stability, are faster, and require fewer point correspondences, compared to state-of-the-art approaches. These properties are vital components for robust navigation in real-time systems, and we demonstrate on both synthetic and real data that our method outperforms other solvers, and yields superior motion estimation(1).

    Ladda ner fulltext (pdf)
    fulltext
  • 119273.
    Örtegren, Hanna
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Arbete och arbetsliv.
    Wahlberg, Ellinor
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Arbete och arbetsliv. Linköpings universitet, Institutionen för beteendevetenskap och lärande, Pedagogik och sociologi.
    Att arbeta i ett aktivitetsbaserat kontor - givande eller påfrestande?: En kvalitativ studie om hur anställda upplever det aktivitetsbaserade kontoret och dess implementering.2019Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Bakgrund och syfte:Arbetet i ett aktivitetsbaserat kontor innebär både utmaningar och möjligheter. Syftet med studien är därför att undersöka vilka dessa är genom att studera hur ett företag som implementerat konceptet genomförde införandet, vilka effekter konceptet medfört samt huruvida arbetssättet tillgodoser den enskilde medarbetarens behov.

    Metod:Studien grundas i en kvalitativ metod och semistrukturerade intervjuer genomförda på ett fastighetsbolag som implementerat konceptet. Empirin har sedan analyserats och diskuterats i relation till forskning och teori inom aktuellt området.

    Resultat:Resultatet visar att implementeringsprocessen har stor inverkan på hur konceptet upplevs och används efter införandet samt att både kunskaps- och informationsflödet påverkats positivt. Resultatet visar på utmaningar gällande koncentration och avskildhet, vilket lett till vissa justeringar.

    Slutsatser:Viktiga slutsatser är betydelsen av att i ett tidigt skede av processen involvera medarbetarna i den förändring som arbetssättet innebär samt att konceptet kan ha en positiv inverkan på kunskaps- och informationsspridningen samt sammanhållningen.

    Ladda ner fulltext (pdf)
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  • 119274.
    Örtegren, Jonas
    et al.
    Department of Polymer Technology, Royal Institute of Technology, Stockholm, Sweden.
    Andersson, Gunnar
    Physics Department, Chalmers University of Technology, Göteborg, Sweden.
    Busson, Philippe
    Department of Polymer Technology, Royal Institute of Technology, Stockholm, Sweden.
    Hult, Anders
    Department of Polymer Technology, Royal Institute of Technology, Stockholm, Sweden.
    Gedde, Ulf W.
    Department of Polymer Technology, Royal Institute of Technology, Stockholm, Sweden.
    Eriksson, Anders
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Hälsouniversitetet.
    Lindgren, Mikael
    National Defence Research Establishment, Linköping, Sweden.
    Improved thermal stability of pyroelectric polymers by crosslinking of ferroelectric liquid crystals2001Ingår i: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 105, nr 42, s. 10223-10227Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Monofunctional ferroelectric liquid crystalline monomers and a blend of monofunctional/bifunctional ferroelectric liquid crystalline monomers were photopolymerized, yielding a side-chain liquid crystalline polymer and a cross-linked polymer, respectively. The cross-linked polymer exhibited higher thermal stability than the side-chain liquid crystalline polymer and was pyroelectric up to 170 °C, whereas the side-chain liquid crystalline polymer lost most of its pyroelectricity at 38 °C. It is shown by electrooptic and birefringence measurements that cross-linking in the unwound SmC* phase prevented the reoccurrence of the helical superstructure.

  • 119275.
    Örtegren, Jonas
    et al.
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Busson, Philippe
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Gedde, Ulf W.
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Hult, Anders
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Eriksson, Anders
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Lindgren, Mikael
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Andersson, Gunnas
    Physics Department, Chalmers University of Technology, Göteborg, Sweden.
    Cone motion viscosity and optical second harmonic generation of ferroelectric liquid crystalline dendrimers2001Ingår i: Liquid crystals (Print), ISSN 0267-8292, E-ISSN 1366-5855, Vol. 28, nr 6, s. 861-868Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We report second harmonic generation in a ferroelectric liquid crystalline trimer and ferroelectric liquid crystalline dendrimers of first, second and third generation. Thin cells were filled with the compounds by capillary forces at elevated temperature, and cooled from the surface stabilized ferroelectric state to below the glass transition temperature, while kept in an electric field. The cone motion viscosity and the threshold electric field for unwinding of the helix axis of the chiral tilted smectic mesophases were studied separately at elevated temperature, and these data were used to optimize the preparation of the films. The measured response time was between 0.3 and 3ms, which corresponds to a cone motion viscosity between 0.5 and 50 Pa s. Second harmonic generation was studied both at elevated temperature with an electric field and at room temperature with and without electric field. The first generation dendrimer exhibited a strong increase in the second order non-linear optical response with time at room temperature. The d 23-coefficient of this dendrimer was approximately four times larger than for the other macromolecules and was 0.045 pm V-1. The relatively large d-coefficient of the first generation dendrimer is ascribed to crystallization, which improved the orientation of the molecular dipoles.

  • 119276.
    Örtegren, Jonas
    et al.
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Busson, Philippe
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Gedde, Ulf W.
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Hult, Anders
    Department of Polymer Technology, Royal Institute of Technology, Sweden.
    Eriksson, Anders
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Lindgren, Mikael
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Arntzén, Per-Otto
    National Defence Research Establishment, Linköping, Sweden.
    Hermann, David S.
    Physics Department, Chalmers University of Technology,Göteborg, Sweden.
    Rudquist, Per
    Physics Department, Chalmers University of Technology,Göteborg, Sweden.
    Lagerwall, Sven T.
    Physics Department, Chalmers University of Technology,Göteborg, Sweden.
    Time-dependent nonlinear optical properties of pyroelectric liquid crystalline polymers1999Ingår i: Macromolecular Symposia, ISSN 1022-1360, E-ISSN 1521-3900, Vol. 148, s. 179-195Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Highly oriented pyroelectric liquid-crystalline polymers were prepared by photopolymerization under the influence of a static electric field from binary mixtures of two acrylate monomers exhibiting chiral smectic C mesomorphism. Both monomers contained nitro groups to yield second order nonlinear optical properties (second harmonic generation) and one of the monomers had two functional groups to yield a crosslinked polymer. The room temperature second order nonlinear susceptibility of the polymers showed during the first two hours a 10 % decrease after which it remained constant during the next 48 days. At elevated temperatures there was a significant difference in the nonlinear optical properties over time between crosslinked and uncrosslinked polymers. The uncrosslinked polymer showed a pronounced loss of second order nonlinear optical activity with time at ≥38°C. The crosslinked polymer showed a much smaller and basically a temperature independent decrease rate in the second order nonlinear optical properties at all the ageing temperatures (23-130°C). Both the loss in mesogen order parameter, very evident for the uncrosslinked polymer, and conformational changes occurring within the mesogens (β mechanism), may account for the observations made.

  • 119277.
    Örtegren Kugelberg, Unn
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Central adipocyte functions in specialized caveolae2006Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Obesity and overweight is an increasing health problem in the world. Besides reducing quality of life obesity is a great risk factor for development of diseases such as type 2 diabetes, cardiovascular disease, and stroke. The adipose tissue is a flexible organ that grows in size if the body is provided with excess energy. Adipocytes store the excess energy in the form of triacylglycerol. The incorporation of fat is stimulated by insulin, while catecholamines promote hydrolysis of triacylglycerol. In the membrane of adipocytes there are cave-like invaginations, caveolae, where proteins involved in insulin signalling, such as the insulin receptor are located. The focus of this thesis is on the function, and thereby the importance, of adipocytes and caveolae in metabolism.

    The lipid content of the plasma membrane and caveolae was analyzed and compared to lipid phases determined in model membranes. The amount of different membrane lipids indicated heterogeneity of the caveolae, since there were not enough of some specific molecules to be present in every caveola. Using density gradient ultra centrifugation three different subclasses of caveolae were identified. These subclasses were named according to their relative densities: very high density caveolae, high density caveolae and low density caveolae. There were clear differences between the classes with regard to the distribution of specific proteins in them. In low density caveolae proteins linked to cholesterol metabolism, scavenger receptor class B type I and CD36, were abundant. Proteins involved in fatty acid metabolism, fatty acid transporter protein 1 and 4, acyl CoA-syntethase, perilipin and hormone sensitive lipase, were localized to high density caveolae. Cholesteryl ester uptake from HDL particles and hydrolysis to cholesterol was found in low density caveolae and the uptake of fatty acids was restricted to high density caveolae. Remarkably, the fatty acids were not only taken up via high density caveolae, but also incorporated into triacylglycerol, diacylglycerol, and phosphatidylcholine. This indicates that the whole machinery for lipid synthesis is located in these caveolae.

    In addition to being an energy store the adipose tissue is also an endocrine organ. Several of the secreted proteins affect the metabolism of the body, for instance adiponectin that affects insulin sensitivity. Here adiponectin was located at the plasma membrane to the caveolae, both by biochemical isolation of caveolae and by electron microscopy. Together with earlier findings this indicates that caveolae may be involved in the secretion of adiponectin.

    In conclusion, caveolae are involved in central processes such as glucose metabolism and signalling. Herein it is shown that caveolae is involved in the metabolism of fatty acids and cholesterol and may also be involved in the secretion of the metabolic hormone adiponectin. The findings in this thesis together with previous research establish caveolae as metabolic platforms.

    Delarbeten
    1. Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes
    Öppna denna publikation i ny flik eller fönster >>Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes
    Visa övriga...
    2004 (Engelska)Ingår i: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 271, nr 10, s. 2028-2036Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    We have made a comprehensive and quantitative analysis of the lipid composition of caveolae from primary rat fat cells and compared the composition of plasma membrane inside and outside caveolae. We isolated caveolae from purified plasma membranes using ultrasonication in carbonate buffer to disrupt the membrane, or extraction with nonionic detergent, followed by density gradient ultracentrifugation. The carbonate-isolated caveolae fraction was further immunopurified using caveolin antibodies. Carbonate-isolated caveolae were enriched in cholesterol and sphingomyelin, and the concentration was three- and twofold higher, respectively, in caveolae compared to the surrounding plasma membrane. The concentration of glycerophospholipids was similar suggesting that glycerophospholipids constitute a constant core throughout the plasma membrane. The composition of detergent-insoluble fractions of the plasma membrane was very variable between preparations, but strongly enriched in sphingomyelin and depleted of glycerophospholipids compared to carbonate-isolated caveolae; indicating that detergent extraction is not a suitable technique for caveolae preparation. An average adipocyte caveola contained about 22 × 103 molecules of cholesterol, 7.5 × 103 of sphingomyelin and 23 × 103 of glycerophospholipid. The glycosphingolipid GD3 was highly enriched in caveolae, whereas GM3, GM1 and GD1a were present inside as well as outside the caveolae membrane. GD1b, GT1b, GM2, GQ1b, sulfatide and lactosylceramide sulfate were not detected in caveolae.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-22409 (URN)10.1111/j.1432-1033.2004.04117.x (DOI)1621 (Lokalt ID)1621 (Arkivnummer)1621 (OAI)
    Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    2. Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes
    Öppna denna publikation i ny flik eller fönster >>Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes
    Visa övriga...
    2005 (Engelska)Ingår i: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 280, nr 1, s. 5-8Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    A principal metabolic function of adipocytes is to synthesize triacylglycerol (TG) from exogenous fatty acids. The level of fatty acids has to be tightly controlled in the adipocyte, as they can act as detergents that rapidly dissolve the plasma membrane, causing cell lysis if allowed to accumulate. Fatty acids therefore have to be efficiently converted to TG and stored in the central lipid droplet. We report that in intact primary adipocytes exogenous oleic acid was taken up and directly converted to TG in the plasma membrane, in a novel subclass of caveolae that specifically contains the protein perilipin. Isolated caveolae catalyzed de novo TG synthesis from oleic acid and glycerol 3-phosphate. Electron microscopy revealed the presence of caveolin and perilipin in caveolae and in lipid-laden bulbs in the plasma membrane, and fluorescence microscopy demonstrated colocalization of fatty acids/TG with caveolin and perilipin at the plasma membrane. A second caveolae fraction was isolated, which lacked perilipin and the triacylglycerol synthesizing enzymes. Both caveolae fractions contained caveolin-1 and the insulin receptor. The findings demonstrate that specific subclasses of caveolae carry out specific functions in cell metabolism. In particular, triacylglycerol is synthesized at the site of fatty acid entry in one of these caveolae classes.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-20650 (URN)10.1074/jbc.C400429200 (DOI)15537657 (PubMedID)
    Tillgänglig från: 2009-09-16 Skapad: 2009-09-16 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    3. Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes: segregation of specific proteins and functions
    Öppna denna publikation i ny flik eller fönster >>Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes: segregation of specific proteins and functions
    Visa övriga...
    2006 (Engelska)Ingår i: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 273, nr 14, s. 3381-3392Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Caveolae are nearly ubiquitous plasma membrane domains that in adipocytes vary in size between 25 and 150 nm. They constitute sites of entry into the cell as well as platforms for cell signalling. We have previously reported that plasma membrane-associated caveolae that lack cell surface access can be identified by electron microscopy. We now report the identification, after density gradient ultracentrifugation, of a subclass of very high-density apparently closed caveolae that were not labelled by cell surface protein labelling of intact cells. These caveolae contained caveolin-1 and caveolin-2. Another class of high-density caveolae contained caveolin-1, caveolin-2 and specifically fatty acid transport protein-1, fatty acid transport protein-4, fatty acyl-CoA synthetase, hormone-sensitive lipase, perilipin, and insulin-regulated glucose transporter-4. This class of caveolae was specialized in fatty acid uptake and conversion to triacylglycerol. A third class of low-density caveolae contained the insulin receptor, class B scavenger receptor-1, and insulin-regulated glucose transporter-4. Small amounts of these proteins were also detected in the high-density caveolae. In response to insulin, the insulin receptor autophosphorylation and the amount of insulin-regulated glucose transporter-4 increased in these caveolae. The molar ratio of cholesterol to phospholipid in the three caveolae classes varied considerably, from 0.4 in very high-density caveolae to 0.9 in low-density caveolae. There was no correlation between the caveolar contents of caveolin and cholesterol. The low-density caveolae, with the highest cholesterol concentration, were particularly enriched with the cholesterol-rich lipoprotein receptor class B scavenger receptor-1, which mediated cholesteryl ester uptake from high-density lipoprotein and generation of free cholesterol in these caveolae, suggesting a specific role in cholesterol uptake/metabolism. These findings demonstrate a segregation of functions in caveolae subclasses.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-35681 (URN)10.1111/j.1742-4658.2006.05345.x (DOI)28128 (Lokalt ID)28128 (Arkivnummer)28128 (OAI)
    Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    4. Localization of adiponectin at the plasma membrane in caveolae of human adipocytes
    Öppna denna publikation i ny flik eller fönster >>Localization of adiponectin at the plasma membrane in caveolae of human adipocytes
    (Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    The hormone adiponectin is exclusively secreted by adipocytes and it regulates whole body energy homeostasis primarily by affecting liver and muscles. The circulating level of adiponectin inversely correlates with insulin resistance and type 2 diabetes. Little is known about the secretion of adiponectin by the adipocyte, but in caveolin-1 knockout mice the amount of secreted adiponectin is severely reduced. Here we show that in human adipocytes adiponectin was associated with the plasma membrane and to a specific class of high-density-caveolae. Substantial amounts of adiponectin were also found in the microsomal and cytosolic fractions of adipocytes, while very little was associated with mitochondria, nuclei, or the fat. Adiponectin in isolated caveolae was readily degraded by added trypsin, demonstrating that adiponectin was largely bound to the cytosolic face of the caveolae membrane. The findings indicate that caveolae may have a critical role in the secretion of adiponectin by human adipocytes.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-84835 (URN)
    Tillgänglig från: 2012-10-24 Skapad: 2012-10-24 Senast uppdaterad: 2012-10-24Bibliografiskt granskad
  • 119278.
    Örtegren Kugelberg, Unn
    et al.
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Nätt, Daniel
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Skog, Signe
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Kutter, Claudia
    Karolinska Inst, Sweden.
    Öst, Anita
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    5 XP sRNA-seq: efficient identification of transcripts with and without 5 phosphorylation reveals evolutionary conserved small RNA2021Ingår i: RNA Biology, ISSN 1547-6286, E-ISSN 1555-8584, Vol. 18, nr 11, s. 1588-1599Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Small RNA (sRNA) sequencing has been critical for our understanding of many cellular processes, including gene regulation. Nonetheless, the varying biochemical properties of sRNA, such as 5 nucleotide modifications, make many sRNA subspecies incompatible with common protocols for sRNA sequencing. Here we describe 5XP-seq that outlines a novel strategy that captures a more complete picture of sRNA. By tagging 5 P sRNA during library preparation, 5XP-seq combines an open approach that includes all types of 5MODIFIER LETTER PRIME-terminal modifications (5 X), with a selective approach for 5-phosphorylated sRNA (5 P). We show that 5XP-seq not only enriches phosphorylated miRNA and piRNA but successfully discriminates these sRNA from all other sRNA species. We further demonstrate the importance of this strategy by successful inter-species validation of sRNAs that would have otherwise failed, including human to insect translation of several tRNA (tRFs) and rRNA (rRFs) fragments. By combining 5 insensitive library strategies with 5 sensitive tagging, we have successfully tackled an intrinsic bias in modern sRNA sequencing that will help us reveal the true complexity and the evolutionary significance of the sRNA world.

  • 119279.
    Örtegren Kugelberg, Unn
    et al.
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Yin, Lan
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Öst, Anita
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Karlsson, Helen
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Yrkes- och miljömedicin. Linköpings universitet, Hälsouniversitetet.
    Nyström, Fredrik
    Linköpings universitet, Institutionen för medicin och vård, Internmedicin. Linköpings universitet, Hälsouniversitetet.
    Strålfors, Peter
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes: segregation of specific proteins and functions2006Ingår i: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 273, nr 14, s. 3381-3392Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Caveolae are nearly ubiquitous plasma membrane domains that in adipocytes vary in size between 25 and 150 nm. They constitute sites of entry into the cell as well as platforms for cell signalling. We have previously reported that plasma membrane-associated caveolae that lack cell surface access can be identified by electron microscopy. We now report the identification, after density gradient ultracentrifugation, of a subclass of very high-density apparently closed caveolae that were not labelled by cell surface protein labelling of intact cells. These caveolae contained caveolin-1 and caveolin-2. Another class of high-density caveolae contained caveolin-1, caveolin-2 and specifically fatty acid transport protein-1, fatty acid transport protein-4, fatty acyl-CoA synthetase, hormone-sensitive lipase, perilipin, and insulin-regulated glucose transporter-4. This class of caveolae was specialized in fatty acid uptake and conversion to triacylglycerol. A third class of low-density caveolae contained the insulin receptor, class B scavenger receptor-1, and insulin-regulated glucose transporter-4. Small amounts of these proteins were also detected in the high-density caveolae. In response to insulin, the insulin receptor autophosphorylation and the amount of insulin-regulated glucose transporter-4 increased in these caveolae. The molar ratio of cholesterol to phospholipid in the three caveolae classes varied considerably, from 0.4 in very high-density caveolae to 0.9 in low-density caveolae. There was no correlation between the caveolar contents of caveolin and cholesterol. The low-density caveolae, with the highest cholesterol concentration, were particularly enriched with the cholesterol-rich lipoprotein receptor class B scavenger receptor-1, which mediated cholesteryl ester uptake from high-density lipoprotein and generation of free cholesterol in these caveolae, suggesting a specific role in cholesterol uptake/metabolism. These findings demonstrate a segregation of functions in caveolae subclasses.

  • 119280.
    Örtegren, Unn
    et al.
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Aboulaich, Nabila
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Öst, Anita
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Strålfors, Peter
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    A new role for caveolae as metabolic platforms2007Ingår i: Trends in endocrinology and metabolism, ISSN 1043-2760, E-ISSN 1879-3061, Vol. 18, nr 9, s. 344-349Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The plasma membrane of cells functions as a barrier to the environment. Caveolae are minute invaginations of the membrane that selectively carry out the exchange of information and materials with the environment, by functioning as organizers of signal transduction and through endocytosis. Recent findings of uptake of different metabolites and of lipid metabolism occurring in caveolae, point to a new general function of caveolae. As gateways for the uptake of nutrients across the plasma membrane, and as platforms for the metabolic conversion of nutrients, especially in adipocytes, caveolae are now emerging as active centers for many aspects of intermediary metabolism, with implications for our understanding of obesity, diabetes and other metabolic disorders.

  • 119281.
    Örtegren, Unn
    et al.
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Karlsson, Margareta
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Blazic, Natascha
    Department of Clinical Neuroscience, Sahlgrenska University Hospital/Mölndal, Göteborg University, Mölndal, Sweden.
    Blomqvist, Maria
    Department of Clinical Neuroscience, Sahlgrenska University Hospital/Mölndal, Göteborg University, Mölndal, Sweden.
    Nyström, Fredrik
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Gustavsson, Johanna
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Fredman, Pam
    Department of Clinical Neuroscience, Sahlgrenska University Hospital/Mölndal, Göteborg University, Mölndal, Sweden.
    Strålfors, Peter
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes2004Ingår i: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 271, nr 10, s. 2028-2036Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We have made a comprehensive and quantitative analysis of the lipid composition of caveolae from primary rat fat cells and compared the composition of plasma membrane inside and outside caveolae. We isolated caveolae from purified plasma membranes using ultrasonication in carbonate buffer to disrupt the membrane, or extraction with nonionic detergent, followed by density gradient ultracentrifugation. The carbonate-isolated caveolae fraction was further immunopurified using caveolin antibodies. Carbonate-isolated caveolae were enriched in cholesterol and sphingomyelin, and the concentration was three- and twofold higher, respectively, in caveolae compared to the surrounding plasma membrane. The concentration of glycerophospholipids was similar suggesting that glycerophospholipids constitute a constant core throughout the plasma membrane. The composition of detergent-insoluble fractions of the plasma membrane was very variable between preparations, but strongly enriched in sphingomyelin and depleted of glycerophospholipids compared to carbonate-isolated caveolae; indicating that detergent extraction is not a suitable technique for caveolae preparation. An average adipocyte caveola contained about 22 × 103 molecules of cholesterol, 7.5 × 103 of sphingomyelin and 23 × 103 of glycerophospholipid. The glycosphingolipid GD3 was highly enriched in caveolae, whereas GM3, GM1 and GD1a were present inside as well as outside the caveolae membrane. GD1b, GT1b, GM2, GQ1b, sulfatide and lactosylceramide sulfate were not detected in caveolae.

  • 119282.
    Örtegren, Unn
    et al.
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Scherer, Philipp
    Albert Einstein College of Medicine, New York, NY, USA.
    Strålfors, Peter
    Linköpings universitet, Institutionen för biomedicin och kirurgi, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Localization of adiponectin at the plasma membrane in caveolae of human adipocytesManuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    The hormone adiponectin is exclusively secreted by adipocytes and it regulates whole body energy homeostasis primarily by affecting liver and muscles. The circulating level of adiponectin inversely correlates with insulin resistance and type 2 diabetes. Little is known about the secretion of adiponectin by the adipocyte, but in caveolin-1 knockout mice the amount of secreted adiponectin is severely reduced. Here we show that in human adipocytes adiponectin was associated with the plasma membrane and to a specific class of high-density-caveolae. Substantial amounts of adiponectin were also found in the microsomal and cytosolic fractions of adipocytes, while very little was associated with mitochondria, nuclei, or the fat. Adiponectin in isolated caveolae was readily degraded by added trypsin, demonstrating that adiponectin was largely bound to the cytosolic face of the caveolae membrane. The findings indicate that caveolae may have a critical role in the secretion of adiponectin by human adipocytes.

  • 119283.
    Örtenberg, Alexander
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska fakulteten.
    Parallelization of DIRA and CTmod Using OpenMP and OpenCL2015Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Parallelization is the answer to the ever-growing demands of computing power by taking advantage of multi-core processor technology and modern many-core graphics compute units. Multi-core CPUs and many-core GPUs have the potential to substantially reduce the execution time of a program but it is often a challenging task to ensure that all available hardware is utilized. OpenMP and OpenCL are two parallel programming frameworks that have been developed to allow programmers to focus on high-level parallelism rather than dealing with low-level thread creation and management. This thesis applies these frameworks to the area of computed tomography by parallelizing the image reconstruction algorithm DIRA and the photon transport simulation toolkit CTmod. DIRA is a model-based iterative reconstruction algorithm in dual-energy computed tomography, which has the potential to improve the accuracy of dose planning in radiation therapy. CTmod is a toolkit for simulating primary and scatter projections in computed tomography to optimize scanner design and image reconstruction algorithms. The results presented in this thesis show that parallelization combined with computational optimization substantially decreased execution times of these codes. For DIRA the execution time was reduced from two minutes to just eight seconds when using four iterations and a 16-core CPU so a speedup of 15 was achieved. CTmod produced similar results with a speedup of 14 when using a 16-core CPU. The results also showed that for these particular problems GPU computing was not the best solution.

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    Parallelization of DIRA and CTmod using OpenMP and OpenCL
  • 119284.
    Örtenberg, Alexander
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Medicinska fakulteten.
    Magnusson, Maria
    Linköpings universitet, Institutionen för systemteknik, Datorseende. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Medicinska fakulteten.
    Sandborg, Michael
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.
    Alm Carlsson, Gudrun
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.
    Malusek, Alexandr
    Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    PARALLELISATION OF THE MODEL-BASED ITERATIVE RECONSTRUCTION ALGORITHM DIRA2016Ingår i: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 169, nr 1-4, s. 405-409Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    New paradigms for parallel programming have been devised to simplify software development on multi-core processors and many-core graphical processing units (GPU). Despite their obvious benefits, the parallelisation of existing computer programs is not an easy task. In this work, the use of the Open Multiprocessing (OpenMP) and Open Computing Language (OpenCL) frameworks is considered for the parallelisation of the model-based iterative reconstruction algorithm DIRA with the aim to significantly shorten the code’s execution time. Selected routines were parallelised using OpenMP and OpenCL libraries; some routines were converted from MATLAB to C and optimised. Parallelisation of the code with the OpenMP was easy and resulted in an overall speedup of 15 on a 16-core computer. Parallelisation with OpenCL was more difficult owing to differences between the central processing unit and GPU architectures. The resulting speedup was substantially lower than the theoretical peak performance of the GPU; the cause was explained.

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    fulltext
  • 119285.
    Örtenberg, Eveline
    Linköpings universitet, Institutionen för fysik, kemi och biologi.
    Optical properties of water absorbing textiles for camouflage2023Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Background matching, a form of camouflage, involves species developing patterns and coloration that closely resemble their environment. Humans have utilized camouflage and background matching, particularly in military applications, to reduce detectable characteristics, known as signatures. Recent advancements in sensor systems necessitate the development of effective camouflage in the short-wave infrared (SWIR) range (0.9 – 2.5 µm). However, absorption of SWIR radiation is heavily influenced by water, and dry textile materials may be easily detectable against a forest background due to their low water content. To address this challenge, this master's thesis explores the integration of hydration onto a textile fabric to reduce the signature in SWIR.

    Various fabric types were included in this study. The optical properties of these textiles, both when wet and dry, were evaluated using SWIR imaging and UV-VIS-NIR spectroscopy, and compared to foliage. Surface modifications were employed to introduce hydrophobic properties to the fabric, such as the application of water-repelling agents (Nikwax and OrganoTex) or functionalized silica nanoparticles. The water evaporation rates of untreated and surface-treated fabrics were assessed. However, the hydrophobic surface did not significantly reduce water evaporation from the fabrics. Similarly, the addition of a nanocellulose-based hydrogel on the fabric surface did not result in a significant change in evaporation. Combining the hydrogel with water-repelling solutions in a multilayer configuration indicated prolonged evaporation, but further tests are required to validate this finding.

    This master's thesis demonstrates that introducing water into a dry textile fabric alters its spectral properties, making it more similar to foliage. However, the primary challenge lies in retaining water within the material for improved camouflage in SWIR wavelengths.

    Ladda ner fulltext (pdf)
    fulltext
  • 119286.
    Örtenberg, Ulrika
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Pedagogik och didaktik. Linköpings universitet, Utbildningsvetenskap.
    Skrivutveckling vid läs- och skrivsvårigheter: Svensklärares skriftliga återkoppling på textproduktion av gymnasieelever i läs- och skrivsvårigheter2022Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Studien undersöker hur gymnasielärare i svenska på högskoleförberedande program kommenterar texter som är producerad av elever i läs- och skrivsvårigheter. Syftet är att studera såväl skrivuppgifter som textkommentarer skrivna av lärare med fokus på att hitta skrivstödjande strukturer i de båda textformerna. I studien ingick tre lärare från tre olika gymnasieskolor och en skrivuppgift i svenska2. Lärare använder skriftlig återkoppling som ett sätt för att främja elevers skrivutveckling. Studien undersöker relationen mellan lärares kommentarer på en skrivuppgift och elevtexten utifrån att lärandet sker i ett samspel med omgivningen. För att analysera skrivuppgifterna och textkommentarerna används texttriangeln (Hoel, 2001, Dysthe et al., 2011) och en skrivmodell (Hayes & Berninger, Wengelin, 2021). Det är två verktyg som är användbara för att analysera d v s bryta ner text i mindre delar för att få syn på vilka olika kognitiva nivåer en skrivuppgift kan kräva av en elev och också vilka färdigheter som behöver användas i form av arbetsminne och uppmärksamhet. En elev i läs- och skrivsvårigheter kan behöva välja mellan den lokala nivån i texttriangeln som rör formalia och stavning till förmån för den globala nivån som rör syfte och mottagare. En van skribent kan hantera nivåerna utan större problem och pendla mellan nivåerna, både i texttriangeln men också i skrivmodellen. För en elev i läs- och skrivsvårigheter kan den kognitiva energin vara begränsad vilket gör att eleven behöver stödstrukturer i såväl skrivuppgiften som vid textproduktion. Lärarnas kommentarer visar att det är vanligt att kommentera stavning och meningsbyggnad samtidigt som man också kommenterar mer abstrakta företeelser som analys, reflektion och beskrivning i texten. Det i sin tur kan göra att för en elev i läs- och skrivsvårigheter blir det svårt att på egen hand lösa uppgiften utifrån kommentarerna. Beröm förekommer men det är sällan det är förknippat med tydliga exempel på vad som är bra. Resultatet visar att lärare behöver kunskap i hur läs- och skrivsvårigheter kan yttra sig i en skriven text och vilken typ av skriftlig återkoppling som främjar skrivutveckling

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    fulltext
  • 119287.
    Örtengren, Malin
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling.
    Torstensson, Tobias
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling.
    Box vs styck: Ett beslutsunderlag till Stadium AB gällande styckhantering i distributionslagret som alternativ till boxar2007Självständigt arbete på avancerad nivå (magisterexamen), 20 poäng / 30 hpStudentuppsats
    Abstract [sv]

    Stadium AB är ett av de största detaljhandelsföretagen i Sverige, som designar, köper och säljer sportutrustning samt sportmodeprodukter. I Stadiums butiker säljs både produkter från märkesleverantörer, exempelvis Adidas och Nike, samt varumärken med egen design, exempelvis SOC, 4D och Everest. Stadium befinner sig i en bransch där kundernas efterfrågan ständigt förändras med mode och säsong. Detta gör branschen komplex och medför att det ställs stora krav på varuförsörjningen till butikerna så att produkterna kommer i rätt volymer och vid rätt tidpunkt till respektive butik. Anledningen till detta är att undvika bristkostnader eller att bli tvungna att rea ut produkter med minskade intäkter som följd.

    I dagsläget använder sig Stadium av så kallade boxar för att introducera och fylla på butikerna med produkter. Boxarna innehåller ett förutbestämt antal av en produkt, exempelvis tjugo röda t-shirtar. Användningen av boxarna medför att det är svårare att styra rätt produkt till rätt butik, vilket kan öka kostnaderna för brist och realisation. En mer precis styrning av produkterna till butikerna vore möjlig att uppnå genom att använda styckhantering istället för boxar. Stadium är därför intresserat av hur styckhantering som alternativ till boxar skulle påverka logistikflödet, med avseende på kostnader och leveransservice, vilket är syftet med den här studien.

    För att besvara syftet med studien kartlades först kostnaderna och leveransservicen för boxhanteringen i dagens distributionssystem genom intervjuer, tidsstudier och analys av historiska data. Sedan uppskattades hur kostnaden och leveransservicen förändras om styckhantering används istället för boxar.

    Resultatet i denna studie är inte svart eller vitt utan hamnar i en gråzon där frasen ”det beror på…” skulle kunna användas. Om Stadium ska använda boxar eller styck till sina produkter beror mycket på den karakteristik produkten har. De tre viktigaste parametrarna som framkommit i denna studie som påverkar hur kostnaderna förändras är:

    - Antal storlekar i boxen.

    - Antal produkter i boxen.

    - Volymen för produkterna.

    Antalet storlekar i boxen och antalet produkter påverkar hanteringskostnaden i distributionslagret vid en övergång till styckhantering så att den ökar. Volymen för produkten påverkar transportkostnaderna så att den kan minska vid en övergång till styckhantering.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 119288.
    Örtnäs, Anna
    Linköpings universitet, Institutionen för utbildningsvetenskap.
    Elevers vardagsuppfattningar om tekniska system2007Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats
    Abstract [sv]

    Elever ska enligt kursplanerna i teknik få förståelse för de tekniska system de möter i sitt dagliga liv. Genom att eleverna får kunskap om teknik i allmänhet och tekniska system i synnerhet får de möjlighet att påverka sina liv som medborgare i en demokrati. I litteraturen saknas idag studier om elevers uppfattningar om tekniska system. Syftet med detta examensarbete är därför att studera vilka vardagsuppfattningar elever har om de tekniska system de möter i vardagen. Studien utgår från systemteori vilken ger en möjlighet att utnyttja det gemensamma mönster som kännetecknar analys av system. Genom enskilda intervjuer har jag studerat hur elever i år 8 och år 2 på gymnasiet uppfattar tekniska system, såsom mobiltelefonsystemet, tvättmaskinen och aluminiumburkens system. Vid intervjuerna användes tankestöttor, d v s föremål och bilder som anknyter till de tekniska systemen, vilket inspirerats av studier om begreppsuppfattning inom naturvetenskapen. Som ett komplement till samtalet uppmanades informanterna att skissa sin förståelse av systemen på papper. Resultaten visar att eleverna på högstadiet och gymnasiet har god kunskap om de tekniska systemen i denna studie. Informanterna har förmågan att se systemens struktur med delsystem. De visar kunskap om sambanden mellan människa och teknik och människans olika roller. Studien har givit mig värdefulla kunskaper om elevernas vardagsuppfattningar om tekniska system vilket ger mig möjlighet att lägga upp min framtida undervisning med utgångspunkt i deras konkreta erfarenheter av teknik i vardagen.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 119289.
    Örtqvist, Eva
    et al.
    Astrid Lindgrens Barnsjukhus Stockholm.
    Ludvigsson, Johnny
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Pediatrik. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    Åman, Jan
    Barnkliniken Universitetssjukhuset, Örebro.
    Johansson, Calle
    Barnkliniken Ryhovs sjukhus, Jönköping.
    Karlsson, Anders
    Medicinkliniken Akademiska sjukhuset, Uppsala.
    Forsander, Gun
    Barnkliniken Lasarettet, Falun.
    Lindgren, Fredrik
    Sachsska Barnsjukhuset Stockholm.
    Persson, Bengt
    Astrid Lindgrens Barnsjukhus Stockholm.
    Berglund, Lars
    Clinical Research Centre Uppsala Universitet.
    Berne, Christian
    Medicinkliniken Akademiska sjukhuset, Uppsala.
    Bengtsson, Mats
    Klinisk Immunologi Uppsala Universitet.
    Björk, Elisabeth
    Medicinkliniken Akademiska sjukhuset, Uppsala.
    Wallensteen, Måna
    Astrid Lindgrens Barnsjukhus Stockholm.
    Temporary preservation of β-cell function by diazoxide treatment in childhood type 1 diabetes2004Ingår i: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 27, nr 9, s. 2191-2197Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE - We examined the effect of diazoxide, an ATP-sensitive K + channel opener and inhibitor of insulin secretion, on β-cell function and remission in children at clinical onset of type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 56 subjects (21 girls and 35 boys, age 7-17 years) were randomized to 3 months of active treatment (diazoxide 5-7.5 mg/kg in divided doses) or placebo in addition to multiple daily insulin injections and were followed for 2 years. RESULTS - Diazoxide decreased circulating C-peptide concentrations by ∼50%. After cessation of the treatment, basal and meal-stimulated C-peptide concentrations increased to a maximum at 6 months, followed by a decline. Meal-stimulated C-peptide concentration was significantly higher at 12 months (0.43 ± 0.22 vs. 0.31 ± 0.26 nmol/l, P = 0.018) and tended to fall less from clinical onset to 24 months in the diazoxide- vs. Placebo-treated patients (-0.05 ± 0.24 vs. -0.18 ± 0.26 nmol/l, P = 0.064). At 24 months, the meal-stimulated C-peptide concentrations were 0.24 ± 0.20 and 0.20 ± 0.17 nmol/l, respectively. Side effects of diazoxide were prevalent. CONCLUSIONS - This study demonstrates that partial inhibition of insulin secretion for 3 months at onset of childhood type 1 diabetes suspends the period of remission and temporarily preserves residual insulin production. Further evaluation of the full potential of β-cell rest will require compounds with less side effects as well as protocols optimized for sustained secretory arrest.

  • 119290.
    Örtqvist, Å.
    et al.
    Karolinska Institute, Danderyd Hospital, Stockholm, Sweden.
    Valtonen, M.
    University Central Hospital, Helsinki, Finland.
    Cars, O.
    Uppsala University, Sweden.
    Wahl, M.
    Östra Hospital, Göteborg University, Sweden.
    Saikku, P.
    University of Oulu and National Public Health Institute, Finland.
    Jean, C.
    Rhone DPC Europe, Paris, France.
    Augustinsson (Nilsdotter-Augustinsson), Åsa
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Medicincentrum, Infektionskliniken i Östergötland.
    Oral empiric treatment of community-acquired pneumonia: A multicenter, double-blind, randomized study comparing sparfloxacin with roxithromycin. The Scandinavian Sparfloxacin Study Group1996Ingår i: Chest, ISSN 0012-3692, E-ISSN 1931-3543, Vol. 110, nr 6, s. 1499-1506Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    STUDY OBJECTIVE:

    Comparison of efficacy and safety of sparfloxacin (Spfx) vs roxithromycin (ROXI) for treatment of community-acquired pneumonia (CAP).

    DESIGN:

    Multicenter, double-blind, randomized study.

    SETTING:

    Twenty-three university and community hospitals in Scandinavia.

    PATIENTS:

    Three hundred four adults (> or = 18 years of age) with CAP treated as outpatients (25%) or inpatients (75%).

    INTERVENTIONS:

    Randomization 1:1 to Spfx, 400 mg on day 1, then 200 mg once daily, or ROXI, 150 mg twice daily, 10 to 14 days. Safety and efficacy analyses in intention-to-treat (ITT) and evaluable populations.

    RESULTS:

    Three hundred three of 304 patients were included in the ITT and safety analyses and 260 (86%) were evaluable at the end of follow-up. Streptococcus pneumoniae was the cause of pneumonia in 62 (20%) patients (11 with bacteremia), Chlamydia pneumoniae in 40 (13%), and Mycoplasma pneumoniae in 38 (13%) patients. The success rates for Spfx and ROXI at the end of follow-up were 82% and 72%, respectively, in the ITT population, and 94% and 79%, respectively, in the evaluable population. The odds ratio Spfx/ROXI for success was 4.5 (95% confidence interval, 1.9, 10.8) for the evaluable population. Both drugs were, overall, equally safe. GI symptoms were the most common adverse experiences in both groups. Prolongation of QTc, without clinical symptoms, was seen in 3% of Spfx patients and in 1% of ROXI patients, and photosensitivity, mostly mild to moderate, was seen in 5% of the Spfx group.

    CONCLUSIONS:

    Oral treatment with Spfx was superior to ROXI for the treatment of moderately severe CAP. Spfx was effective for all isolated pathogens, including S pneumoniae, and may be an alternative for empiric treatment of CAP, especially in areas with a high incidence of beta-lactam-resistant pneumococci.

  • 119291.
    Örulv, Linda
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle.
    Demens: diagnosen som utmanar våra rädslor och fördomar2011Ingår i: Diagnos & identitet / [ed] Georg Drakos, Lars-Christer Hydén, Stockholm: Gothia Förlag AB, 2011, s. 100-129Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 119292. Beställ onlineKöp publikationen >>
    Örulv, Linda
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Fragile identities, patched-up worlds: Dementia and meaning-making in social interaction2008Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [sv]

    Denna avhandling fokuserar på det meningsskapande och begripliggörande som fortgår vid tilltagande demenssjukdom, i det sociala samspelet, och de utmaningar för demens-omsorgen som detta innebär. Studien är aktörsorienterad och adresserar frågan om hur personer med åldersrelaterade progressiva demenssjukdomar i den vardagliga kommuni-kationen söker förstå sina situationer, omgivningen och sina liv – alltsammans inom ra-men för det dagliga samspelet på ett demensboende. Av särskilt intresse är hur dessa per-soner hanterar problem som har att göra med att handla tillsammans med andra i en gemensamt delad värld och hitta sin roll i det pågående samspelet, och hur de etablerar och upprätthåller en identitet i detta samspel. Detta trots svåra minnesproblem, desorien-tering i tid och rum, olika sätt att förstå den pågående situationen samt svårigheter att be-rätta om sina liv på ett sätt som både stämmer överens med biografiska data och har en tillfredsställande temporal organisering. Avhandlingen adresserar också frågan om hur omsorgspersonalen kan hantera det komplexa samspelet mellan de boende i den dagliga omsorgen, med avseende på att upprätthålla och respektera dessa personers värdighet.

    Studien ansluter till en växande tradition av att studera interaktion vid demens som meningsbaserad och situerad i en kontext snarare än enbart som beteende som orsakas av kognitiva svårigheter. Metodologiskt är studien etnografisk och bygger på observationer fördelade över en tidsperiod av sex månader. Materialet, som består av ca 150 h videoma-terial och kompletterande fältanteckningar, möjliggör att samspelet studeras både i detalj och i relation till det större sammanhang som det ingår i.

    Studien visar på kvarvarande kompetenser och bidrar med ny kunskap om strategier som personerna med demens använder sig av i ett aktivt, kreativt och på många sätt ratio-nellt meningsskapande i det sociala samspelet med andra människor. Detta diskuteras i termer av resurser för demensomsorgen i relation till den stora utmaning som det innebär att lappa ihop och upprätthålla en begriplig och socialt delad värld, samt upprätthålla kon-tinuitet med personernas livshistorier på ett sätt som möjliggör en önskad identitet.

    Delarbeten
    1. Confabulation: sense-making, self-making and world-making in dementia
    Öppna denna publikation i ny flik eller fönster >>Confabulation: sense-making, self-making and world-making in dementia
    2006 (Engelska)Ingår i: Discourse Studies, ISSN 1461-4456, Vol. 8, nr 5, s. 647-673Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    This study is concerned with the productive aspects of confabulation as it occurs spontaneously in dementia care, in its context, and in interaction with other care recipients. Confabulation is approached as a social and discursive event with distinct narrative features; plots and formerly established genres of plots, storylines, are used by confabulators in order to understand, manage and interact socially in the present situation. Three main functions of confabulation are discerned: 1) making sense of the current situation (sense-making); 2) maintaining a personal identity in interaction with others (self-making); and 3) organizing and legitimizing joint action in the world (world-making). The resources used by confabulating subjects are sparse and not well adjusted to changing conditions, as the number of accessible storylines is limited. This makes it difficult to apply storylines that explain the current situation satisfactorily, provide useful guidelines for how to act, as well as preserve a positive self-identity. Helping with this constitutes a major challenge in dementia care.

    Nyckelord
    Alzheimer’s disease, communication, confabulation, context, dementiam, ethnography
    Nationell ämneskategori
    Kommunikationsvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-13251 (URN)10.1177/1461445606067333 (DOI)
    Tillgänglig från: 2008-05-06 Skapad: 2008-05-06 Senast uppdaterad: 2013-09-04
    2. Placing the place, and placing oneself within it: (dis)orientation and (dis)continuity in dementia
    Öppna denna publikation i ny flik eller fönster >>Placing the place, and placing oneself within it: (dis)orientation and (dis)continuity in dementia
    2010 (Engelska)Ingår i: Dementia, ISSN 1471-3012, E-ISSN 1741-2684, Vol. 9, s. 21-44Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Disorientation as experienced by persons with progressive dementia diseases involves both existential and social dimensions. Based on video observations from a small residential care unit and exploring social interaction on a micro-level, this case study focuses on how a woman with vascular dementia actively tries to make sense of an everyday lunch situation. The analysis addresses strategies used by her to contextualize where she has ended up, and also how the meaning of the place is altered in communication. Findings point to social interaction between residents as an important resource to help maintain continuity with previous social life. However, there also seems to be an impending need for caregivers to help residents patch up their broken life-stories to render everyday situations comprehensible and the setting socially meaningful. Helping them find a way of placing themselves within it — also affording a positive self-identity and continuity with previous life history — is a major challenge in daily care.

    Ort, förlag, år, upplaga, sidor
    Sage Publications, 2010
    Nationell ämneskategori
    Samhällsvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-13252 (URN)10.1177/1471301210364449 (DOI)
    Tillgänglig från: 2008-05-06 Skapad: 2008-05-06 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    3. Narrative and identity in Alzheimer’s disease: a case study
    Öppna denna publikation i ny flik eller fönster >>Narrative and identity in Alzheimer’s disease: a case study
    2009 (Engelska)Ingår i: Journal of Aging Studies, ISSN 0890-4065, E-ISSN 1879-193X, Vol. 23, nr 4, s. 205-214Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    In this case study, focus is on how persons with AD use their remaining linguistic and cognitive resources, together with non-verbal aspects of the storytelling event, as resources in communicating and negotiating their identities in everyday encounters. The results of the analysis, focusing on the telling of the stories, indicate that other aspects than the temporal and referential organization of the narratives has become important resources for the teller in establishing and negotiating identity. The telling of temporally discontinuous narratives does not appear to affect or disrupt the teller's experience of some sort of a continuous sense of self and identity but are probably more a problem to persons without this kind of diagnosis. Being afflicted by AD most likely leads persons to try to invent and use alternative communicative recourses in order to sustain factors like their senses of self and identities. For researchers this makes it important to try to base their analysis on the actual organization of the talk and to focus on the functions of various responses and utterances in the interaction.

    Nyckelord
    identity, narrative, Alzheimer’s disease, performance, story-telling
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-13253 (URN)10.1016/j.jaging.2008.01.001 (DOI)
    Tillgänglig från: 2008-05-06 Skapad: 2008-05-06 Senast uppdaterad: 2017-12-13
    4. Dignity work in dementia care: Sketching a microethical analysis
    Öppna denna publikation i ny flik eller fönster >>Dignity work in dementia care: Sketching a microethical analysis
    2007 (Engelska)Ingår i: Dementia: the International Journal of Social Research and Practice, ISSN 1471-3012, Vol. 6, nr 4, s. 507-525Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    This study is concerned with issues of dignity in dementia care, in situations where staff members handle potential or actual conflicts and interaction problems between residents. Based on empirical data consisting of observations and video recordings, various coping strategies are identified in regard to whether or not, as well as when and how to interfere. Microethical analysis is used in order to discuss these coping strategies in relation to contextual conditions and ways of understanding, and values or aspects of dignity are highlighted. In dialogue with empirical data, nuances of ethical considerations are approached that are otherwise difficult to access analytically — thereby opening the door to a more reflective way of dealing with problematic situations in dementia care.

    Nyckelord
    coping strategies • conflict solving • ethics • ethnography • microethics
    Nationell ämneskategori
    Samhällsvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-13254 (URN)10.1177/1471301207084368 (DOI)
    Tillgänglig från: 2008-05-06 Skapad: 2008-05-06 Senast uppdaterad: 2009-03-09Bibliografiskt granskad
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  • 119293.
    Örulv, Linda
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Hälsouniversitetet.
    Placing the place, and placing oneself within it: (dis)orientation and (dis)continuity in dementia2010Ingår i: Dementia, ISSN 1471-3012, E-ISSN 1741-2684, Vol. 9, s. 21-44Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Disorientation as experienced by persons with progressive dementia diseases involves both existential and social dimensions. Based on video observations from a small residential care unit and exploring social interaction on a micro-level, this case study focuses on how a woman with vascular dementia actively tries to make sense of an everyday lunch situation. The analysis addresses strategies used by her to contextualize where she has ended up, and also how the meaning of the place is altered in communication. Findings point to social interaction between residents as an important resource to help maintain continuity with previous social life. However, there also seems to be an impending need for caregivers to help residents patch up their broken life-stories to render everyday situations comprehensible and the setting socially meaningful. Helping them find a way of placing themselves within it — also affording a positive self-identity and continuity with previous life history — is a major challenge in daily care.

  • 119294.
    Örulv, Linda
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Reframing dementia in Swedish self-help group conversations: Constructing citizenship2012Ingår i: International journal of self help & self care, ISSN 1091-2851, E-ISSN 1541-4450, Vol. 6, nr 1, s. 9-41Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study explores on a micro-level the activity of a self-help group for persons with dementia in Swedish municipal care, based on audio-recordings from 18 months' ethnographic fieldwork. The study focuses on the discursive construction of a shared meaning perspective and its inherent possibilities for liberation. Applying a citizenship perspective, the study approaches people with dementia as vulnerable to marginalization while at the same time capable of agency within the boundaries of their condition. The findings paint a complex picture involving opportunities and limitations of experiential knowledge, issues of double stigmatization, and constructs of being interrelated with other people and with the surrounding society. In the center is the overarching struggle of retaining citizenship in the face of the evolving disease.

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    fulltext
  • 119295.
    Örulv, Linda
    Linköpings universitet, Filosofiska fakulteten.
    Self-help, mutual support and advocacy: peers getting together2017Ingår i: Living with dementia: relations, responses and agency in everyday life / [ed] Lars-Christer Hydén, Eleonor Antelius, Basingstoke: Palgrave Macmillan, 2017, Vol. Sidorna 168-187, s. 168-187Kapitel i bok, del av antologi (Refereegranskat)
  • 119296.
    Örulv, Linda
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, NISAL - Nationella institutet för forskning om äldre och åldrande. Linköpings universitet, Filosofiska fakulteten.
    Självhjälpsgrupper, nätverk och aktivism2016Ingår i: Att leva med demens / [ed] Ingrid Hellström, Lars-Christer Hydén, Malmö: Gleerups Utbildning AB, 2016, 1, s. 203-211Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 119297.
    Örulv, Linda
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    The subjectivity of disorientation: moral stakes and concerns2014Ingår i: Beyond Loss: dementia, identity, personhood / [ed] Lars-Christer Hydén, Hilde Lindemann, and Jens Brockmeier, Oxford: Oxford University Press, 2014, s. 191-207Kapitel i bok, del av antologi (Refereegranskat)
    Abstract [en]

    This collection of interdisciplinary essays by international researchers tries to see beyond the loss in dementia, exploring it as transformation and change of personhood and identity that typically is embedded in social life. The chapters identify three important themes: persons and personhood, identity and agency, and the social and the communal.

  • 119298.
    Örulv, Linda
    Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för tema, Tema Kommunikation.
    Where are we? What's going to happen? Spontaneous narrating and dementia (presentation baserad på artikelarbete tillsammans med Lars-Christer Hydén)2003Ingår i: First Interdisciplinary Conference on Communication, Medicine Ethics COMET, 26-28 June 2003,2003, 2003Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

      

  • 119299.
    Örulv, Linda
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Hydén, Lars-Christer
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Confabulation: sense-making, self-making and world-making in dementia2006Ingår i: Discourse Studies, ISSN 1461-4456, Vol. 8, nr 5, s. 647-673Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study is concerned with the productive aspects of confabulation as it occurs spontaneously in dementia care, in its context, and in interaction with other care recipients. Confabulation is approached as a social and discursive event with distinct narrative features; plots and formerly established genres of plots, storylines, are used by confabulators in order to understand, manage and interact socially in the present situation. Three main functions of confabulation are discerned: 1) making sense of the current situation (sense-making); 2) maintaining a personal identity in interaction with others (self-making); and 3) organizing and legitimizing joint action in the world (world-making). The resources used by confabulating subjects are sparse and not well adjusted to changing conditions, as the number of accessible storylines is limited. This makes it difficult to apply storylines that explain the current situation satisfactorily, provide useful guidelines for how to act, as well as preserve a positive self-identity. Helping with this constitutes a major challenge in dementia care.

  • 119300.
    Örulv, Linda
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Hälsa och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Nikku, Nina
    Linköpings universitet, Institutionen för beteendevetenskap och lärande, Avdelningen för sociologi (SOC). Linköpings universitet, Filosofiska fakulteten.
    Dignity work in dementia care: Sketching a microethical analysis2007Ingår i: Dementia: the International Journal of Social Research and Practice, ISSN 1471-3012, Vol. 6, nr 4, s. 507-525Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study is concerned with issues of dignity in dementia care, in situations where staff members handle potential or actual conflicts and interaction problems between residents. Based on empirical data consisting of observations and video recordings, various coping strategies are identified in regard to whether or not, as well as when and how to interfere. Microethical analysis is used in order to discuss these coping strategies in relation to contextual conditions and ways of understanding, and values or aspects of dignity are highlighted. In dialogue with empirical data, nuances of ethical considerations are approached that are otherwise difficult to access analytically — thereby opening the door to a more reflective way of dealing with problematic situations in dementia care.

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