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  • 151.
    Abdelrahman, Islam Mohamedy
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. The Plastic Surgery Unit, Surgery Department, Suez Canal University, Ismailia, Egypt.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Mossaad, Bassem
    The Plastic Surgery Unit, Surgery Department, Suez Canal University, Ismailia, Egypt.
    Sjöberg, Folke
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Elmasry, Moustafa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. The Plastic Surgery Unit, Surgery Department, Suez Canal University, Ismailia, Egypt.
    Evaluation of Male Breast Glandular Liposculpturing, Response on Commentary2019In: Aesthetic Plastic Surgery, ISSN 0364-216X, E-ISSN 1432-5241, Vol. 43, no 2, p. 548-549Article in journal (Other academic)
    Abstract [en]

    n/a

  • 152.
    Abdelrahman, Islam Mohamedy
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Suez Canal Univ, Egypt.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Mossaad, Bassem
    Suez Canal Univ, Egypt.
    Sjöberg, Folke
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
    Elmasry, Moustafa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Suez Canal Univ, Egypt.
    Male Breast Glandular Liposculpturing, Response on Commentary2018In: Aesthetic Plastic Surgery, ISSN 0364-216X, E-ISSN 1432-5241, Vol. 42, no 6, p. 1709-1710Article in journal (Other academic)
    Abstract [en]

    n/a

  • 153.
    Abdelrahman, Islam Mohamedy
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Suez Canal Univ, Egypt.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Sjöberg, Folke
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
    Mossaad, Bassem
    Suez Canal Univ, Egypt.
    Elmasry, Moustafa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Suez Canal Univ, Egypt.
    Male Breast Glandular Liposculpture Challenges2018In: Aesthetic Plastic Surgery, ISSN 0364-216X, E-ISSN 1432-5241, Vol. 42, no 5, p. 1437-1437Article in journal (Other academic)
    Abstract [en]

    n/a

  • 154.
    Abdelrahman, Islam
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. The Plastic Surgery Unit, Surgery Department, Suez Canal University, Ismailia, Egypt.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Fredrikson, Mats
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Sjöberg, Folke
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
    Elmasry, Moustafa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. The Plastic Surgery Unit, Surgery Department, Suez Canal University, Ismailia, Egypt.
    Use of the burn intervention score to calculate the charges of the care of burns2019In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 45, no 2, p. 303-309Article in journal (Refereed)
    Abstract [en]

    Background To our knowledge this is the first published estimate of the charges of the care of burns in Sweden. The Linköping Burn Interventional Score has been used to calculate the charges for each burned patient since 1993. The treatment of burns is versatile, and depends on the depth and extension of the burn. This requires a flexible system to detect the actual differences in the care provided. We aimed to describe the model of burn care that we used to calculate the charges incurred during the acute phase until discharge, so it could be reproduced and applied in other burn centres, which would facilitate a future objective comparison of the expenses in burn care. Methods All patients admitted with burns during the period 2010–15 were included. We analysed clinical and economic data from the daily burn scores during the acute phase of the burn until discharge from the burn centre. Results Total median charge/patient was US$ 28 199 (10th–90th centiles 4668-197 781) for 696 patients admitted. Burns caused by hot objects and electricity resulted in the highest charges/TBSA%, while charges/day were similar for the different causes of injury. Flame burns resulted in the highest mean charges/admission, probably because they had the longest duration of stay. Mean charges/patient increased in a linear fashion among the different age groups. Conclusion Our intervention-based estimate of charges has proved to be a valid tool that is sensitive to the procedures that drive the costs of the care of burns such as large TBSA%, intensive care, and operations. The burn score system could be reproduced easily in other burn centres worldwide and facilitate the comparison regardless of the differences in the currency and the economic circumstances.

  • 155.
    Abdelrahman, Islam
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Suez Canal Univ, Surg Dept, Plast Surg Unit, Ismailia, Egypt.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Mossaad, Bassem
    Plastic Surgery Unit, Surgery Department Suez, Canal University, Ismailia, Egypt.
    Sjöberg, Folke
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
    Elmasry, Moustafa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynaecomastia2018In: Aesthetic Plastic Surgery, ISSN 0364-216X, E-ISSN 1432-5241, Vol. 42, no 2, p. 1222-1230Article in journal (Refereed)
    Abstract [en]

    Background

    Gynaecomastia is a benign enlargement of the male breast, of which the psychological burden on the patient can be considerable, with the increased risk of disorders such as depression, anxiety, and social phobia. Minimal scarring can be achieved by liposuction alone, though it is known to have a limited effect on the dense glandular and fibroconnective tissues. We know of few studies published on “liposuction alone”, so we designed this study to evaluate the outcome of combining liposuction with glandular liposculpturing through two axillary incisions as a single treatment for the management of grades I and II gynaecomastia.

    Methods

    We made a retrospective analysis of 18 patients with grade I or II gynaecomastia who were operated on by combined liposuction and glandular liposculpturing using a fat disruptor cannula, without glandular excision, during the period 2014–2016. Patient satisfaction was assessed using the Breast Evaluation Questionnaire (BEQ), which is a 5-point Likert scale (1 = very dissatisfied; 2 = dissatisfied; 3 = neither; 4 = satisfied; 5 = very satisfied). The post-operative aesthetic appearance of the chest was evaluated by five independent observers on a scale from 1 to 5 (5 = considerable improvement).

    Results

    The patient mean (SD) overall satisfaction score was 4.7 (0.7), in which 92% of the responders were “satisfied” to “very satisfied”. The mean (SD) BEQ for all questions answered increased from 2.1 (0.2) “dissatisfied” preoperatively to 4.1 (0.2) “satisfied” post-operatively. The observers’ mean (SD) rate for the improvement in the shape of the front chest wall was 4.1 (0.7). No haematomas were recorded, one patient developed a wound infection, and two patients complained of remnants of tissue. The median (IQR) body mass index was 27.4 (26.7–29.4), 11 patients had gynaecomastia grade I, and 7 patients grade II. The median (IQR) volume of aspirated fat was 700 ml (650–800), operating time was 67 (65–75) minutes, 14 patients had general anaesthesia, and hospital charges were US$ 538 (481–594).

    Conclusions

    Combined liposuction and liposculpturing using the fat disruptor cannula resulted in satisfied patients and acceptable outcomes according to the observers’ ratings. It could be a useful alternative with an outcome that corresponds to that of more expensive methods.

  • 156.
    Abdgawad, M.
    et al.
    Departments of Nephrology, Lund University, Lund, Sweden.
    Gunnarsson, L.
    Departments of Nephrology, Lund University, Lund, Sweden.
    Bengtsson, A. A.
    Departments of Rheumatology, Lund University, Lund, Sweden.
    Geborek, P.
    Departments of Rheumatology, Lund University, Lund, Sweden.
    Nilsson, L.
    Departments of Haematology, Lund University, Lund, Sweden.
    Segelmark, Mårten
    Departments of Nephrology, Lund University, Lund, Sweden.
    Hellmark, T.
    Departments of Nephrology, Lund University, Lund, Sweden.
    Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression2010In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 161, no 1, p. 89-97Article in journal (Refereed)
    Abstract [en]

    Proteinase 3 (PR3) is a major autoantigen in anti-neutrophil cytoplasmic antibodies (ANCA)-associated systemic vasculitis (AASV), and the proportion of neutrophils expressing PR3 on their membrane (mPR3+) is increased in AASV. We have shown recently that mPR3 and CD177 are expressed on the same cells in healthy individuals. In this study we try to elucidate mechanisms behind the increased mPR3 expression in AASV and its relationship to CD177. All neutrophils in all individuals were either double-positive or double-negative for mPR3 and CD177. The proportion of double-positive neutrophils was increased significantly in AASV and systemic lupus erythematosus patients. The proportion of mPR3+/CD177+ cells was not correlated to general inflammation, renal function, age, sex, drug treatment and levels of circulating PR3. AASV patients had normal levels of granulocyte colony-stimulating factor and granulocyte–macrophage colony-stimulating factor. Pro-PR3 was found to constitute 10% of circulating PR3 but none of the mPR3. We found increased mRNA levels of both PR3 and CD177 in AASV, but they did not correlate with the proportion of double-positive cells. In cells sorted based on membrane expression, CD177–mRNA was several-fold higher in mPR3+ cells. When exogenous PR3 was added to CD177-transfected U937 cells, only CD177+ cells bound PR3 to their membrane. In conclusion, the increased membrane expression of PR3 found in AASV is not linked directly to circulating PR3 or PR3 gene transcription, but is dependent upon CD177 expression and correlated with the transcription of the CD177 gene.

  • 157.
    Abdgawad, Mohamed
    et al.
    Lund University.
    Pettersson, Asa
    Lund University.
    Gunnarsson, Lena
    Lund University.
    Bengtsson, Anders A
    Lund University.
    Geborek, Pierre
    Lund University.
    Nilsson, Lars
    Lund University.
    Segelmark, Mårten
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Nephrology UHL.
    Hellmark, Thomas
    Lund University.
    Decreased Neutrophil Apoptosis in Quiescent ANCA-Associated Systemic Vasculitis2012In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 3Article in journal (Refereed)
    Abstract [en]

    Background: ANCA-Associated Systemic Vasculitis (AASV) is characterized by leukocytoclasis, accumulation of unscavenged apoptotic and necrotic neutrophils in perivascular tissues. Dysregulation of neutrophil cell death may contribute directly to the pathogenesis of AASV. less thanbrgreater than less thanbrgreater thanMethods: Neutrophils from Healthy Blood Donors (HBD), patients with AASV most in complete remission, Polycythemia Vera (PV), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and renal transplant recipients (TP) were incubated in vitro, and the rate of spontaneous apoptosis was measured by FACS. Plasma levels of cytokines and sFAS were measured with cytometric bead array and ELISA. Expression of pro/anti-apoptotic factors, transcription factors C/EBP-alpha, C/EBP-beta and PU.1 and inhibitors of survival/JAK2-pathway were measured by real-time-PCR. less thanbrgreater than less thanbrgreater thanResults: AASV, PV and RA neutrophils had a significantly lower rate of apoptosis compared to HBD neutrophils (AASV 50 +/- 14% vs. HBD 64 +/- 11%, p andlt; 0.0001). In RA but not in AASV and PV, low apoptosis rate correlated with increased plasma levels of GM-CSF and high mRNA levels of anti-apoptotic factors Bcl-2A1 and Mcl-1. AASV patients had normal levels of G-CSF, GM-CSF and IL-3. Both C/EBP-alpha, C/EBP-beta were significantly higher in neutrophils from AASV patients than HBD. Levels of sFAS were significantly higher in AASV compared to HBD. less thanbrgreater than less thanbrgreater thanConclusion: Neutrophil apoptosis rates in vitro are decreased in AASV, RA and PV but mechanisms seem to differ. Increased mRNA levels of granulopoiesis-associated transcription factors and increased levels of sFAS in plasma were observed in AASV. Additional studies are required to define the mechanisms behind the decreased apoptosis rates, and possible connections with accumulation of dying neutrophils in regions of vascular lesions in AASV patients.

  • 158.
    Abdi, Allan
    Linköping University, Department of Management and Engineering, Political Science.
    Tunisiens tillfälliga övergångsregim 2011: En teorikonsumerande fallstudie av politiska aktörers betydelse för övergången till demokratiskt styre2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    According to The Economist Democracy Index, Tunisia was at 2.79 during 2010 and by the end of 2011 they had climbed up to 5.53. Therefore Tunisia entered a new category, called hybrid regime. This was a step closer to a more democratic regime. Rustow Dankwart, Shain Yossi and Linz J. Juan would say that the interim government and the political actors within it had a significant impact on Tunisias increase in democracy index. Therefore the aim of this study took the shape of a theory consuming case study. The purpose of the study was to analyze the political actors and the interim government importance during the Tunisian democratic transition, with the delimitation to the year 2011. The results firstly showed us the categorization hardliners within the authoritarian coalition in combination with radicals in the oppositional coalition. During the second interim government the categorization changes from hardliners to softliners. During the third, we see a glint of moderates within the opposition. Secondly, the results showed us that there is evidence of an opposition-led, power-sharing and incumbent-led caretaker regime in Tunisia. The study discusses two conclusions about political actors during the transition. Firstly, the importance of radicals within the opposition and secondly the importance of the authoritarian coalition changing from hardliners to softliners, which allowed the country to transition. Within the categorization of the interim government we have come to the conclusion that the opposition-led government played a significant role in the Tunisian transition.

  • 159.
    Abdiu, Avni
    Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Linköping University, Faculty of Health Sciences.
    Growth regulation in sarcomas: studies in vivo and in cell culture1999Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Sarcomas are malignant tumors of mesenchymal origin, and can arise in soft-tissue and in bones. It has been suggested that the abnormal growth regulation in sarcoma cells may be due to an autocrine mechanism, in which the cells are stimulated by an endogenous production of growth factors. Platelet-derived growth factor (PDGF) has been detected in sarcomas, and may be one of the growth factors important for sarcoma growth.

    PDGF, originally discovered in platelets, is produced by, and binds to, a variety of cells. PDGF plays several roles both in normal conditions and in disease.

    Suramin is a polyanionic drug with antineoplastic activities, and is known to dissociate growth factors from their receptors. Suramin has been shown to inhibit growth in several tumors and tumor cell lines; however, some tumor cells have been unaffected, or even stimulated, by suramin.

    The present work was performed in order to a) examine the effects of suramin on sarcoma growth in vivo; b) investigate the kinetics of extravascularly administered PDGF in vivo; c) establish and characterize human sarcoma cells in vitro, including their relation to PDGF; d) evaluate the effects of suramin on sarcoma growth in vitro; e) compare the effects of PDGF on sarcoma growth in vivo and in vitro.

    Suramin was shown to inhibit growth of two different human osteosarcoma xenografts grown in nude mice. The action is believed to be mainly cytostatic, as the tumors continued to grow, albeit at a lower pace: the tumors of the suramin treated mice had a volume of one-third or less than the untreated ones. The percentage of cells in S and G2-M cell cycle phases was increased by suramin treatment, suggesting a selective effect of the drug in the S and G2 period.

    Blood and serum levels of 125I, after extravascular administration of 125I-PDGF-AB by intraperitoneal, intramuscular or subcutaneous injection in mice, were found to rise to a maximum 2-4 hours after injection. The levels of radioactivity persisted over several hours. Precipitiation of serum with 10% trichloracetic acid revealed that more than 50% of the radioactivity was in a macromolecular form. Gel chromatography of the serum showed that a major portion of the radioactive material in the circulation had the same molecular size as the original 125I-PDGF-AB.

    Eight cell lines derived from malignant fibrous histiocytomas (MFH) were established and characterized. A heterogeneity in the morphology of the MFH cell lines was noted. This heterogeneity was also reflected in the expression of mRNA for PDGF, transforming growth factor-alpha (TGF-/alpha/) and their receptors, ability to grow in serumfree media and secretion of PDGF into growth media. Two cell lines, able to grow in serum-free medium, coexpressed MRNA for PDGF, TGF-/aplpha/ and their receptors, suggesting that they may be regulated in an autocrine manner. However, other cell lines, unable to grow in a serum-free medium, also displayed this coexpression of mRNA. The simultaneous expression of a growth factor and its receptor is therefore not generally indicative of an autocrine mechanism.

    All cell lines, unable to grow in a serum-free medium, were growth inhibited by high-dose suramin (200 ug/ml). The two cell lines, previously noted to grow under serum-free conditions, were not affected by the high-dose suramin treatment. The finding that only serum-dependent human MFH cell lines were inhibited by high doses of suramin indicates that serum dependence in vitro may predict sensitivity of sarcoma cells to suramin.

    Two human sarcoma xenografts, one osteosarcoma and one malignant fibrous histiocytoma, were treated with human PDGF-AB when grown in nude mice. No effects on tumor growth were noted, although immunohistochemical studies revealed an expression of PDGF receptors. Furthermore, both sarcomas were markedly stimulated by PDGF-AB in vitro. It is concluded that mechanisms or factors other than available PDGF were limiting the growth of the examined tumors in vivo.

  • 160.
    Abdiu, Avni
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
    Larsson, Sven-Erik
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Wasteson, Åke
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
    Walz, Thomas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    Suramin blocks growth-stimulatory effects of platelet-derived growth factor on malignant fibrous histiocytomas in vitro.1999In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 146, p. 189-194Article in journal (Refereed)
  • 161.
    Abdiu, Avni
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
    Nakamura, Hajime
    Sahaf, Bita
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
    Yodoi, Junji
    Holmgren, Arne
    Rosén, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
    Thioredoxin blood level increases after severe burn injury2000In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 2, no 4, p. 707-716Article in journal (Refereed)
    Abstract [en]

    We have investigated the thioredoxin (TRX) levels in severely burned patients and the possible origin of TRX, based on the recent understanding that TRX is a potent antioxidant with cytoprotective functions. Serum and plasma samples from burns patients and healthy blood donors were collected during the first 10 post-bum days and analyzed in a sandwich TRX enzyme-linked immunosorbent assay (ELISA). The TRX levels found were correlated to a panel of blood tests. The presence of TRX in platelets was investigated by immunoelectron microscopy and Western blotting. TRX serum levels of the severely burned patients showed a significant increase, with a mean serum TRX concentration on the day of injury of 76.5 ▒ 19.5 ng/ml (mean ▒ SD) and on post-burn day one 122.6 ▒ 66.9 ng/ml, compared to control blood donor levels of 22.7 ▒ 12.2 ng/ml (p = 0.0041 and 0.0117, respectively). A second peak of increase was found on post-burn days 7 to 9 with a four- to five-fold rise in concentration compared to controls. TRX elevation correlated well with increased platelet (p = 0.007) and leukocyte counts (p = 0.002). We also demonstrated by immunoelectron microscopy and Western blotting the presence of TRX in platelets. In conclusion, our demonstration of TRX release in burn injuries indicates that the TRX system is involved in a rapid antioxidant defense, coagulation processes, cell growth, and control of the extracellular peroxide tone intimately linked to cytoprotection and wound healing in burns. One of the cell types that delivers TRX promptly and efficiently into the blood may be the platelet.

  • 162.
    Abdiu, Avni
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
    Ohannessian, Peter
    Östergötlands Läns Landsting, Reconstruction Centre, Department of Oral Surgery UHL.
    Berggren, Anders
    Linköping University, Department of Clinical and Experimental Medicine, Surgery . Linköping University, Faculty of Health Sciences.
    The nasal alar elevator: A new device that may reduce the need for primary operation of the nose in patients with cleft lip2009In: SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, ISSN 0284-4311, Vol. 43, no 2, p. 71-74Article in journal (Refereed)
    Abstract [en]

    To improve the shape of the cleft lip nose preoperatively, we have developed the nasal alar elevator. This has been used routinely since 1996 on all our cleft lip patients who have an asymmetrical nose, from the first week after birth until the date of primary lip surgery. We present our 11-year-long experience of using the device on patients born with complete, unilateral cleft lip. In this study 56 children, born between 1996 and 2006 inclusive, with complete unilateral cleft lip, had preoperative treatment with the elevator. During this 11-year period, continuous evaluation during the preoperative period, and its effects on the cleft lip nose, were evaluated, both preoperatively and postoperatively. Our results show that the preoperative use of the device has led to less need for primary nasal surgery. Instead of having to have a primary rhinoplasty (McComb) together with a lip plasty, as a routine, now only about 30% of the patients need primary surgical correction of the nose. If nasal correction is needed, a rather limited undermining of skin over the ala on the cleft side will often be sufficient. The use of a nasal elevator reduces both the length and the extent of the primary intervention, without compromising the final result.

  • 163.
    Abdiu, Avni
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
    Wingren, Sten
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
    Larsson, S-E
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Wasteson, Åke
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
    Walz, Thomas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    Effects of human platelet-derived growth factor-AB on sarcoma growth in vitro and in vivo.1999In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 141, p. 39-45Article in journal (Refereed)
  • 164.
    Abdollahi Sani, Negar
    et al.
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Robertsson, Mats
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Cooper, Philip
    De La Rue Plc, Overton, Hampshire, UK .
    Wang, Xin
    Acreo AB, Norrköping, Sweden.
    Svensson, Magnus
    Acreo AB, Norrköping, Sweden.
    Andersson Ersman, Peter
    Acreo AB, Norrköping, Sweden.
    Norberg, Petronella
    Acreo AB, Norrköping, Sweden.
    Nilsson, Marie
    Acreo AB, Norrköping, Sweden.
    Nilsson, David
    Acreo AB, Norrköping, Sweden.
    Liu, Xianjie
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Hesselbom, Hjalmar
    Hesselbom Innovation and Development HB, Huddinge, Sweden .
    Akesso, Laurent
    De La Rue Plc, Overton, Hampshire, UK .
    Fahlman, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Crispin, Xavier
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Engquist, Isak
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Berggren, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology. Acreo AB, Norrköping, Sweden.
    Gustafsson, Goran
    Acreo AB, Norrköping, Sweden.
    All-printed diode operating at 1.6 GHz2014In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 111, no 33, p. 11943-11948Article in journal (Refereed)
    Abstract [en]

    Printed electronics are considered for wireless electronic tags and sensors within the future Internet-of-things (IoT) concept. As a consequence of the low charge carrier mobility of present printable organic and inorganic semiconductors, the operational frequency of printed rectifiers is not high enough to enable direct communication and powering between mobile phones and printed e-tags. Here, we report an all-printed diode operating up to 1.6 GHz. The device, based on two stacked layers of Si and NbSi2 particles, is manufactured on a flexible substrate at low temperature and in ambient atmosphere. The high charge carrier mobility of the Si microparticles allows device operation to occur in the charge injection-limited regime. The asymmetry of the oxide layers in the resulting device stack leads to rectification of tunneling current. Printed diodes were combined with antennas and electrochromic displays to form an all-printed e-tag. The harvested signal from a Global System for Mobile Communications mobile phone was used to update the display. Our findings demonstrate a new communication pathway for printed electronics within IoT applications.

  • 165.
    Abdollahi Sani, Negar
    et al.
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Wang, Xin
    Acreo Swedish ICT AB, Sweden.
    Granberg, Hjalmar
    INNVENTIA AB, Sweden.
    Andersson Ersman, Peter
    Acreo Swedish ICT AB, Sweden.
    Crispin, Xavier
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Dyreklev, Peter
    Acreo Swedish ICT AB, Sweden.
    Engquist, Isak
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Gustafsson, Göran
    Acreo Swedish ICT AB, Sweden.
    Berggren, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Flexible Lamination-Fabricated Ultra-High Frequency Diodes Based on Self-Supporting Semiconducting Composite Film of Silicon Micro-Particles and Nano-Fibrillated Cellulose2016In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, no 28921Article in journal (Refereed)
    Abstract [en]

    Low cost and flexible devices such as wearable electronics, e-labels and distributed sensors will make the future "internet of things" viable. To power and communicate with such systems, high frequency rectifiers are crucial components. We present a simple method to manufacture flexible diodes, operating at GHz frequencies, based on self-adhesive composite films of silicon micro-particles (Si-mu Ps) and glycerol dispersed in nanofibrillated cellulose (NFC). NFC, Si-mu Ps and glycerol are mixed in a water suspension, forming a self-supporting nanocellulose-silicon composite film after drying. This film is cut and laminated between a flexible pre-patterned Al bottom electrode and a conductive Ni-coated carbon tape top contact. A Schottky junction is established between the Al electrode and the Si-mu Ps. The resulting flexible diodes show current levels on the order of mA for an area of 2 mm(2), a current rectification ratio up to 4 x 10(3) between 1 and 2 V bias and a cut-off frequency of 1.8 GHz. Energy harvesting experiments have been demonstrated using resistors as the load at 900 MHz and 1.8 GHz. The diode stack can be delaminated away from the Al electrode and then later on be transferred and reconfigured to another substrate. This provides us with reconfigurable GHz-operating diode circuits.

  • 166.
    Abdolmajid Ahmad, Bookan
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    Programmering av generativ konst i C# .Net2014Independent thesis Basic level (degree of Bachelor), 180 HE creditsStudent thesis
    Abstract [sv]

    Detta examensarbete utfördes på IDA (Institutionen för datavetenskap) vid Linköpings universitet. 

    Syftet med det här examensarbetet var att utveckla ett program som skulle skapa förutsättningar för generativ konst med hjälp av MyPaint som är ett digitalt rit/målarverktyg. Metoden gick ut på att registrera vad användaren skapat för komponenter, dvs. musinteraktioner och kortkommandon, och därefter använda dem algoritmiskt.

    Examensarbetet resulterades i ett program (SharpArt), som fångar musinteraktioner samt simulerar tangentbordstryckningar (kortkommandon) från och till Mypaint, vilket i sin tur skapar komponenter som används algoritmiskt. Programmet kan även positionera objektet på canvasen enligt det önskade koordinatvärdet.

  • 167.
    Abdul Aziz Hasan Ali, Aamir
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Shahzad, Muhammad Adil
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    A Joint Subcarrier/Power allocation Scheme for OFDMA-based Cellular Networks2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The assignment of this master thesis consists of initiating power, subcarrier allocation in a dynamic FFR based scheme designed for multi-cell OFDMA networks and to enhance the throughput of all center users in bandwidth hungry borrower cells (overloaded cells) which was previously degraded by original FFR3 scheme as a result of partitioning of system bandwidth into center and edge bands respectively. The method uses band borrowing to compensate center user’s throughput loss in a semi and fully overloaded system. The scheme uses dynamic programming method (0/1 knapsack problem) to bargain an edge band on various power levels and tends to check the best combination (power and sub-carrier) which the system can utilize while still maintaining acceptable throughput loss for the users at the edge of the neighboring cell (lender cell).

    The algorithm consists of generating a borrowing request to neighboring cells for utilizing their edge bands by the overloaded borrower cell if their average center user throughput reaches below a minimum threshold value set in the system. The borrowing method uses 0/1 knapsack problem to capture an edge band based on limiting factors of total cost in average throughput losses by neighbors (Ci) and Un (tolerable mean user edge user throughput loss by lending cell). While solving knapsack problem the lender (neighbors) will check Ci and Un before granting the right to use its edge band. The later stage requires reducing subcarrier power level in order to utilize the lenders edge band using "soft borrower" mode. The borrowed sub-carriers will be activated take power from the original center band sub-carriers of the overloaded cell by taking into account the interference between the lender and the borrower. In case of negative (0) reply from the lender cell after the first request, multiple requests are generated at reduce power level at every step to order to acquire more bands. If a neighbor has band borrowing requests from multiple overloaded base stations, the band will be granted to the one which gives minimal loss in terms of throughput to the lender cell.

    The simulation results are analyzed w.r.t reuse-1 and FFR3 scheme of a multi cell regular and irregular scenarios comprising of lightly to heavily overloaded cells with various subcarrier allocation patterns. An overhead and time assessment is also presented between borrower and lender cells. Simulation results show an increase of 60% in center user’s throughput w.r.t original FFR3 scheme with an acceptable loss of 18% at the edges in complex overloaded scenarios while the overall system throughout increases by 35%.

  • 168.
    Abdul Malek, Nurul Aida
    et al.
    Universiti Tun Hussein Onn Malaysia (UTHM), Malaysia / Department of Production, University of Vaasa, Finland.
    Shahzad, Khuram
    Department of Production, University of Vaasa, Finland.
    Takala, Josu
    Department of Production, University of Vaasa, Finland.
    Bojnec, Stefan
    Faculty of Management, University of Primorska, Slovenia.
    Papler, Drago
    Faculty of Management, University of Primorska, Slovenia.
    Liu, Yang
    Department of Production, University of Vaasa, Finland.
    Analyzing Sustainable Competitive Advantage: Strategically Managing Resource Allocations to Achieve Operational Competitiveness2015In: Management and Production Engineering Review, ISSN 2080-8208, E-ISSN 2082-1344, Vol. 6, no 4, p. 70-86Article in journal (Refereed)
    Abstract [en]

    In today’s dynamic business environment, a key challenge for all companies is to make adaptive adjustments to their manufacturing strategy. This study demonstrates the competitive priorities of manufacturing strategy in hydro-power case company to evaluate the level of sustainable competitive advantage and also to further analyze how business strategies are aligned with manufacturing strategies. This research is based on new holistic analytical evaluation of manufacturing strategy index, sense and respond, and sustainable competitive advantage models. These models help to describe, evaluate, and optimize resource allocation to meet the performance requirements in dynamic decision making. Furthermore, these models evaluate operational competitiveness for manufacturing strategies according to the multi-criteria priority. The results show that the adjustments of competitive priorities in manufacturing strategies by implementing the proposed holistic analytical models are helpful in strategically managing business operations. The discussion derives the most critical attributes in business operations while alignment of resource allocation with competitive priorities help to strategically focus those attributes. In conclusion, we argue that resource allocation and manufacturing strategies have become the most important capabilities in a business environment where companies focus to get a sustainable competitive advantage.

  • 169.
    Abdulahad, Bassam
    et al.
    Linköping University, Department of Computer and Information Science.
    Lounis, Georgios
    Linköping University, Department of Computer and Information Science.
    A user interface for the ontology merging tool SAMBO2004Independent thesis Basic level (professional degree)Student thesis
    Abstract [en]

    Ontologies have become an important tool for representing data in a structured manner. Merging ontologies allows for the creation of ontologies that later can be composed into larger ontologies as well as for recognizing patterns and similarities between ontologies. Ontologies are being used nowadays in many areas, including bioinformatics. In this thesis, we present a desktop version of SAMBO, a system for merging ontologies that are represented in the languages OWL and DAML+OIL. The system has been developed in the programming language JAVA with JDK (Java Development Kit) 1.4.2. The user can open a file locally or from the network and can merge ontologies using suggestions generated by the SAMBO algorithm. SAMBO provides a user-friendly graphical interface, which guides the user through the merging process.

  • 170.
    Abdulhamidova, Nurangez
    Linköping University, Department of Management and Engineering.
    The European Union-Central Asia: in the light of the New Strategy2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Central Asia is a region strategically located on the crossroads of the two continents. The region is represented by five states (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) with different level of economic development and with the population amounting to over 60 million people. The region is rich in energy resources, represented by oil, gas, coal and hydropower resources.

    The thesis analyses, assesses and scrutinises one of the topical issues of the contemporary international relations - cooperation between the European Union and Central Asian states before and after adoption in June 2007 of the ‘European Union and Central Asia: Strategy for a New Partnership’, an important political document in the history of relations between the two parties.

    The new stage of cooperation is analysed more comprehensively accentuating priorities set in the Strategy. Analysis of the current state of affairs is conducted concerning some important issues of the Strategy related to regional cooperation between Central Asian states, such as integrated water management and development of hydro-energy system, issues of diversification of hydrocarbons supply routes from the region to Europe and provision of energy security, etc.

    Issues of cooperation between the European Union and Tajikistan are analysed as a case study. State of affairs between some of the European Union member-states and Central Asian countries is characterised.

    The thesis also scrutinises other regional/international actors engaged in cooperation with Central Asia (such as China, Russia, the US, Shanghai Cooperation Organisation, etc.) and their potential for interaction with the European Union for more effective joint solution of the problems existing in the region is assessed.

    In the conclusion, development of cooperation between the European Union and Central Asian states is scrutinised, the problems and their possible solutions in this regard are analysed, and the recommendations for increasing effectiveness of cooperation between the two parties are presented.

    The European Union’s foreign policy in Central Asia is interpreted from perspective of the theories of international relations namely neorealism, neoliberalism and constructivism in the end of every chapter.

  • 171.
    Abdulhamidova, Nurangez
    Linköping University, Department of Management and Engineering.
    The European Union-Central Asia: in the light of the New Strategy2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Central Asia is a region strategically located at the crossroads of the two continents: Asia and Europe. The region is represented by five states (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) with different level of economic development and with the population amounting to over 60 million people. The region is rich in energy resources represented by oil, gas, coal and water resources.

    The thesis analyses, assesses and scrutinises one of the topical issues of the contemporary international relations - cooperation between the European Union and Central Asian states before and after adoption in June 2007 of the ‘European Union and Central Asia: Strategy for a New Partnership’,  an important political document in the history of relations between the two parties.

    The new stage of cooperation is analysed more comprehensively accentuating priorities set in the Strategy. Analysis of the current state of affairs is conducted concerning some important issues of the Strategy related to regional cooperation between Central Asian states, such as integrated water management and development of hydro-energy system, issues of diversification of hydrocarbons supply routes from the region to Europe and provision of energy security, etc.

    Issues of cooperation between the European Union and Tajikistan are analysed as a case study. State of affairs between the Central Asian states and the European Union Member States actively cooperating with these countries is characterised.

    The thesis also scrutinises other regional/international actors engaged in cooperation with Central Asia (such as China, Russia, the US, Shanghai Cooperation Organisation, etc.) and their potential for interaction with the European Union for more effective joint solution of the problems existing in the region is assessed.

    In the conclusion, development of cooperation between the European Union and Central Asian states is scrutinised, the problems and their possible solutions in this regard are analysed, and the recommendations for increasing effectiveness of cooperation between the two parties are presented.

    The European Union’s policy in Central Asia is interpreted from perspective of the theories of international relations namely neorealism, neoliberalism and constructivism in the research.

  • 172.
    Abdulla, Afrah
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Educational Sciences. Department of Social and Behavioural Studies, Division of Social Pedagogy and Sociology, Högskolan Väst, Trollhättan, Sweden.
    Readiness or resistance?: Newly arrived adult migrants' experiences, meaning making, and learning in Sweden2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This thesis is about newly arrived adult migrants’ meaning making and learning in Swedish society during the two years’ introduction period, after they have received the residence permit. I have specifically studied Arabic speaking adults’ meaning making and learning, by carrying out observations and individual in-depth interviews with 12 migrants. The introduction period consists mainly of three so called introduction measures; the civic orientation course, Swedish for immigrants (SFI), and different work related activities, such as internship at different work places.

    The results show that etablering is about shaping the newly arrived adult migrants into ”good” citizens, through the introduction measures, among other things in the civic orientation course, which is regulated through the policy documents, and which so to say provides meaning to the newly arrived. The “good” citizen has some specific characteristics, which, roughly, are that he or she is independent (and advocates individuality), free, equality thinking, secularized, law-abiding (which includes being honest), responsible, and a “good” parent. These characteristics are expressed in different ways in the civic orientation course, for instance through the course material. The Swedish society is described as something desirable, and different from what is implied to be ”Arabic” values and ways of thinking. The idea of the “good” citizen appears to aim at constructing the adult migrants’ (and their families’) identity, something which many of the study’s respondents make a resistance to.

    As concerns the migrant’s new experiences, it is, for example, those which the migrant get through the contact with the Swedish Public Employment Service (SPES) that affect the meaning making in the new society. The meaning which most of the respondents have made of the SPES’s measures for them is that this authority only offers “prepackaged” solutions, and does not provide the help or support that they need. Also the experiences which the migrant has in the civic orientation course, and the meaning which ”old” migrants give to him or her, play a role when he or she makes meaning of Sweden and Swedes, and of his or her new life situation. Further, it has been shown that it is those experiences that the adult individual has been socialized through, and those which he or she has gained through work or education in his or her country of origin, which affect his or her meaning making in Sweden. It is mostly values which concern child upbringing and religion that lead to a certain understanding and construction of one’s new life. These values, when related to the values which are included in the ”good” citizen idea, also lead to either a resistance or a readiness towards the meaning giving that is embedded in the ”good” citizen notion.

  • 173.
    Abdulla, Afrah
    et al.
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Arts and Sciences.
    Risenfors, Signild
    Högskolan Väst.
    Kursen samhällsorientering för nyanlända: mobilisering och integration för deltagare2013In: Gemenskaper: socialpedagogiska perspektiv / [ed] Lisbeth Eriksson, Gunilla Nilsson, Lars A. Svensson, Göteborg: Daidalos, 2013, p. 117-138Chapter in book (Other academic)
  • 174.
    Abdulla, Ariyan
    et al.
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    Andersson, Erik
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    Heuristiska algoritmer för schemaläggning i real-tidssystem med hänsyn till data beroenden2018Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    The schedule for the jobs in a real-time system can have a huge impact on how the system behave. Since real-time systems are common in safety applications it is important that the scheduling is done in a valid way. Furthermore, one can enhance the performance of the applications by minimizing data latency and jitter. A challenge is that jobs in real-time systems usually have complex constraints making it too time consuming to minimize data latency and jitter to optimality. The purpose of this report is to investigate the possibility of creating high quality schedules using heuristics, with the goal to keep the computational time under one minute. This will be done by comparing three different algorithms that will be used on real scheduling instances provided by the company Arcticus. The first algorithm is a greedy heuristic, the second one a local search and the third one is a metaheuristic, simulated annealing. The results indicate that the data latency can be reduced whilst keeping the computational time below one minute.

  • 175.
    Abdulla, Parosh Aziz
    et al.
    Department of Information Technology, Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Department of Information Technology, Uppsala University, Sweden.
    Chen, Yu-Fang
    Institute of Information Science, Academia Sinica, Taiwan.
    Holik, Lukas
    Faculty of Information Technology, Brno University of Technology, Czech Republic.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Rümmer, Philipp
    Department of Information Technology, Uppsala University, Sweden.
    Stenman, Jari
    Department of Information Technology, Uppsala University, Sweden.
    String Constraints for Verification2014In: 26th International Conference on Computer Aided Verification (CAV 2014), Vienna, Austria, Jul. 9-12, 2014., Berlin: Springer, 2014, p. 150-166Conference paper (Refereed)
    Abstract [en]

    We present a decision procedure for a logic that combines (i) word equations over string variables denoting words of arbitrary lengths, together with (ii) constraints on the length of words, and on (iii) the regular languages to which words belong. Decidability of this general logic is still open. Our procedure is sound for the general logic, and a decision procedure for a particularly rich fragment that restricts the form in which word equations are written. In contrast to many existing procedures, our method does not make assumptions about the maximum length of words. We have developed a prototypical implementation of our decision procedure, and integrated it into a CEGAR-based model checker for the analysis of programs encoded as Horn clauses. Our tool is able to automatically establish the correctness of several programs that are beyond the reach of existing methods.

  • 176.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academia Sinica, Taiwan.
    Leonardsson, Carl
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Automatic fence insertion in integer programs via predicate abstraction2012In: Static Analysis: 19th International Symposium, SAS 2012, Deauville, France, September 11-13, 2012. Proceedings / [ed] Antoine Miné, David Schmidt, Springer Berlin/Heidelberg, 2012, p. 164-180Conference paper (Refereed)
    Abstract [en]

    We propose an automatic fence insertion and verification framework for concurrent programs running under relaxed memory. Unlike previous approaches to this problem, which allow only variables of finite domain, we target programs with (unbounded) integer variables. The problem is difficult because it has two different sources of infiniteness: unbounded store buffers and unbounded integer variables. Our framework consists of three main components: (1) a finite abstraction technique for the store buffers, (2) a finite abstraction technique for the integer variables, and (3) a counterexample guided abstraction refinement loop of the model obtained from the combination of the two abstraction techniques. We have implemented a prototype based on the framework and run it successfully on all standard benchmarks together with several challenging examples that are beyond the applicability of existing methods.

  • 177.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academia Sinica, Taiwan.
    Leonardsson, Carl
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, ESLAB - Embedded Systems Laboratory. Linköping University, The Institute of Technology.
    Counter-Example Guided Fence Insertion under TSO2012In: TACAS 2012, Berlin, Heidelberg: Springer , 2012Conference paper (Refereed)
    Abstract [en]

    We give a sound and complete fence insertion procedure for concurrentfinite-state programs running under the classical TSO memory model. Thismodel allows “write to read” relaxation corresponding to the addition of an unboundedstore buffer between each processor and the main memory. We introducea novel machine model, called the Single-Buffer (SB) semantics, and show thatthe reachability problem for a program under TSO can be reduced to the reachabilityproblem under SB. We present a simple and effective backward reachabilityanalysis algorithm for the latter, and propose a counter-example guided fence insertionprocedure. The procedure is augmented by a placement constraint thatallows the user to choose places inside the program where fences may be inserted.For a given placement constraint, we automatically infer all minimal setsof fences that ensure correctness. We have implemented a prototype and run itsuccessfully on all standard benchmarks together with several challenging examplesthat are beyond the applicability of existing methods.

  • 178.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academia Sinica, Taiwan.
    Leonardsson, Carl
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Memorax, a Precise and Sound Tool for Automatic Fence Insertion under TSO2013In: Tools and Algorithms for the Construction and Analysis of Systems: 19th International Conference, TACAS 2013, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2013, Rome, Italy, March 16-24, 2013. Proceedings, Springer Berlin/Heidelberg, 2013, p. 530-536Conference paper (Refereed)
    Abstract [en]

    We introduce MEMORAX, a tool for the verification of control state reachability (i.e., safety properties) of concurrent programs manipulating finite range and integer variables and running on top of weak memory models. The verification task is non-trivial as it involves exploring state spaces of arbitrary or even infinite sizes. Even for programs that only manipulate finite range variables, the sizes of the store buffers could grow unboundedly, and hence the state spaces that need to be explored could be of infinite size. In addition, MEMORAX in- corporates an interpolation based CEGAR loop to make possible the verification of control state reachability for concurrent programs involving integer variables. The reachability procedure is used to automatically compute possible memory fence placements that guarantee the unreachability of bad control states under TSO. In fact, for programs only involving finite range variables and running on TSO, the fence insertion functionality is complete, i.e., it will find all minimal sets of memory fence placements (minimal in the sense that removing any fence would result in the reachability of the bad control states). This makes MEMORAX the first freely available, open source, push-button verification and fence insertion tool for programs running under TSO with integer variables.

  • 179.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University.
    Atig, Mohammed Faouzi
    Uppsala University.
    Ganjei, Zeinab
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Zhu, Yunyun
    Uppsala University.
    Verification of Cache Coherence Protocols wrt. Trace Filters2015Conference paper (Refereed)
    Abstract [en]

    We address the problem of parameterized verification of cache coherence protocols for hardware accelerated transactional memories. In this setting, transactional memories leverage on the versioning capabilities of the underlying cache coherence protocol. The length of the transactions, their number, and the number of manipulated variables (i.e., cache lines) are parameters of the verification problem. Caches in such systems are finite-state automata communicating via broadcasts and shared variables. We augment our system with filters that restrict the set of possible executable traces according to existing conflict resolution policies. We show that the verification of coherence for parameterized cache protocols with filters can be reduced to systems with only a finite number of cache lines. For verification, we show how to account for the effect of the adopted filters in a symbolic backward reachability algorithm based on the framework of constrained monotonic abstraction. We have implemented our method and used it to verify transactional memory coherence protocols with respect to different conflict resolution policies.

  • 180.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Dwarkadas, Sandhya
    University of Rochester, U.S.A..
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Shriraman, Arrvindh
    Simon Fraser University, Canada.
    Zhu, Yunyun
    Uppsala University, Sweden.
    Verifying Safety and Liveness for the FlexTM Hybrid Transactional Memory2013In: Design, Automation & Test in Europe (DATE 2013), Grenoble, France, March 18-22, 2013., IEEE , 2013, p. 785-790Conference paper (Refereed)
    Abstract [en]

    We consider the verification of safety (strict se- rializability and abort consistency) and liveness (obstruction and livelock freedom) for the hybrid transactional memory framework FLEXTM. This framework allows for flexible imple- mentations of transactional memories based on an adaptation of the MESI coherence protocol. FLEXTM allows for both eager and lazy conflict resolution strategies. Like in the case of Software Transactional Memories, the verification problem is not trivial as the number of concurrent transactions, their size, and the number of accessed shared variables cannot be a priori bounded. This complexity is exacerbated by aspects that are specific to hardware and hybrid transactional memories. Our work takes into account intricate behaviours such as cache line based conflict detection, false sharing, invisible reads or non-transactional instructions. We carry out the first automatic verification of a hybrid transactional memory and establish, by adopting a small model approach, challenging properties such as strict serializability, abort consistency, and obstruction freedom for both an eager and a lazy conflict resolution strategies. We also detect an example that refutes livelock freedom. To achieve this, our prototype tool makes use the latest antichain based techniques to handle systems with tens of thousands of states.

  • 181.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Haziza, Frédéric
    Uppsala University, Sweden.
    Holik, Lukas
    Brno University of Technology, Czech Republic.
    Jonsson, Bengt
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    An Integrated Specification and Verification Technique for Highly Concurrent Data Structures2013In: The 19th International Conference on Tools and Algorithms for the Construction and Analysis of Systems (TACAS 2013), Rome, Italy, March 16-24, 2013. / [ed] Piterman, Nir, Smolka, Scott, 2013Conference paper (Refereed)
    Abstract [en]

    We present a technique for automatically verifying safety properties of concurrent programs, in particular programs which rely on subtle dependencies of local states of different threads, such as lock-free implementations of stacks and queues in an environment without garbage collection. Our technique addresses the joint challenges of infinite-state specifications, an unbounded number of threads, and an unbounded heap managed by explicit memory allocation. Our technique builds on the automata-theoretic approach to model checking, in which a specification is given by an automaton that observes the execution of a program and accepts executions that violate the intended specification.We extend this approach by allowing specifications to be given by a class of infinite-state automata. We show how such automata can be used to specify queues, stacks, and other data structures, by extending a data-independence argument. For verification, we develop a shape analysis, which tracks correlations between pairs of threads, and a novel abstraction to make the analysis practical. We have implemented our method and used it to verify programs, some of which have not been verified by any other automatic method before.

  • 182.
    Abdullah Jan, Mirza
    et al.
    Linköping University, Department of Electrical Engineering.
    Ahsan, Mahmododfateh
    Linköping University, Department of Electrical Engineering.
    Multi-View Video Transmission over the Internet2010Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    3D television using multiple views rendering is receiving increasing interest. In this technology a number of video sequences are transmitted simultaneously and provides a larger view of the scene or stereoscopic viewing experience. With two views stereoscopic rendition is possible. Nowadays 3D displays are available that are capable of displaying several views simultaneously and the user is able to see different views by moving his head.

    The thesis work aims at implementing a demonstration system with a number of simultaneous views. The system will include two cameras, computers at both the transmitting and receiving end and a multi-view display. Besides setting up the hardware, the main task is to implement software so that the transmission can be done over an IP-network.

    This thesis report includes an overview and experiences of similar published systems, the implementation of real time video, its compression, encoding, and transmission over the internet with the help of socket programming and finally the multi-view display in 3D format.  This report also describes the design considerations more precisely regarding the video coding and network protocols.

  • 183.
    Abdullah, M Ailieen
    et al.
    Royal Institute of Technology.
    Öhrwall Rönnbäck, Anna
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Ölundh Sandström, Gunilla
    Royal Institute of Technology.
    Building Networks for Delivering Integrated Product-Service Offerings (IPSOs)2010In: Proceedings of 2nd CIRP IPS2 Conference 2010 - Industrial product-service systems -IPS², CIRP , 2010Conference paper (Refereed)
    Abstract [en]

    The paper describes the effect of forming business networks and collaborations for the purpose of developing an Integrated Product-Service Offering (IPSO) using the Product/Service Systems (PSS). The research method is an in-depth case study of a joint venture formed by four companies developing a new technology for chemical extraction from water sludge waste within the pulp and paper industry.

    Combining literature from PSS, network theories and collaborative product development, this paper puts forward the benefits for SMEs to collaborate in business networks and produce IPSOs when introducing a new technology in an emerging market. The case study shows that working towards the new market would not have been possible if each party acted individually or maintained their traditional buyer-supplieroperator roles, and that IPSOs can reduce the business risk.

  • 184.
    Abdul-Mumuni, Abdallah
    Linköping University, Department of Management and Economics.
    Conflict Resolution in West Africa: A Comparative Analysis of Sierra Leone and Liberia2005Independent thesis Advanced level (degree of Magister)Student thesis
    Abstract [en]

    This paper is a Master thesis for the Master’s program in International and European Relations in the Department of Management and Economics at Linköping University. As the title indicates, the aim of this thesis is to make a comparative analysis of the conflict resolution initiatives that were employed in the Sierra Leonean and Liberian conflicts. The research questions are:

    • What were the root causes and trajectories of the Sierra Leonean and Liberian conflicts?

    • What were the conflict resolution initiatives employed in resolving both conflicts?

    • Why did the Lome Peace Accord succeed in the case of Sierra Leone whilst the Abuja Peace Accord failed in bringing peace to Liberia?

    In order to answer the afore-mentioned questions and fulfil the aim of this paper, a qualitative research method has been chosen. The study is mainly based on secondary sources such as textbooks, official documents from ECOWAS and the UN, articles, magazines and newspapers as well as internet resources. In making the comparative analysis the Conflict Transformation Model as espoused by Kumar Rupesinghe has been utilized. This model has specifically helped in explaining the reasons why peace returned to Sierra Leone but eluded the people of Liberia for a long time. The conclusion drawn from the study is that a multi-track approach is required in dealing with conflicts in West Africa so that it would touch on the context of the conflict, the conflict structure, the intra-party as well as the inter- party divisions and the broader system of society and governance within the conflict area.

  • 185.
    Abe, Y
    et al.
    Tohoku University, Japan; .
    Hara, K
    Tohoku University, Japan; .
    Matsumoto, H
    Tohoku University, Japan; .
    Kobayashi-, J
    Tohoku University, Japan; .
    Sasada, H
    Tohoku University, Japan; .
    Ekwall, H
    Tohoku University, Japan; .
    Rodriguez-Martinez, Heriberto
    Swedish University of Agricultural Sciences; Sweden.
    Sato, E
    Tohoku University, Japan; .
    Feasibility of a nylon-mesh holder for vitrification of bovine germinal vesicle oocytes in subsequent production of viable blastocysts2005In: Biology of Reproduction, ISSN 0006-3363, E-ISSN 1529-7268, Vol. 72, no 6, p. 1416-1420Article in journal (Refereed)
    Abstract [en]

    To improve the feasibility of nylon-mesh holder for vitrification of bovine cumulus-oocytes complexes (GV-COCs) having germinal vesicle, this study was conducted to demonstrate effects of sugars and protocol of exposure in vitrification on subsequent in vitro maturation, ultrastructural changes, and in vitro development in bovine immature oocytes after cryopreservation using nylon mesh. Before vitrification, GV-COCs were exposed to the cryoprotectant, which was composed of 40% (v/v) ethylene glycol, 18% (w/v) Ficoll-70, and 0.3 M sucrose (EFS40) or 0.3 M trehalose (EFT40), either by single step or in a stepwise way. The maturation rates in the stepwise exposure with EFS40 or EFT40 were significantly higher (P less than 0.05) compared with the corresponding rates in the single step. In the stepwise exposure, few abnormalities were observed compared with the single-step exposure, where most oocytes showed a highly vacuolated cytoplasm with many ruptured mitochondria. Cleavage rates in fertilized oocytes previously exposed stepwise to EFS40 or EFT40 were significantly higher than those exposed by the single-step procedure. The cleaved embryos derived from the stepwise exposure to EFS40 developed to blastocysts. After transfer of blastocysts derived from vitrified GV oocytes, a female calf was born. These results indicate that vitrification of large numbers of bovine GV-COCs using a nylon-mesh holder accompanied with stepwise exposure minimizes structural damage in organelles, resulting in yield of viable blastocysts following in vitro embryo production.

  • 186.
    Abebe, Meaza Eshetu
    et al.
    Linköping University, Department of Management and Engineering, Business Administration.
    Kalinina, Ekaterina
    Linköping University, Department of Management and Engineering, Business Administration.
    Coordination of inter-organizational projects within creative industries: A contextual perspective2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Inter-organizational projects have become common forms of organizing in various industries such as construction, advertising, music, film making etc. The unique structural nature of Inter-organizational projects coupled with the fact that they carried out through the participation of multiple organizations, raises issues of coordination. Particularly when it comes to creative industries, coordination is challenged by demand and transactional uncertainties. In order to understand how inter-organizational projects achieve coordination in such situations, it is important to study their interior processes putting in consideration their environmental context. 

    The aim of this research is to study how network embeddedness enhances coordination in inter-organizational projects within creative industries.

    Inter-organizational projects: are projects that are carried out through the collaboration of multiple legally independent organizations

    Inter-organizational networks: refer to sets of long-term ties among independent organizations that are engaged in continuous exchange relations.

    Embeddedness: refers to the continuous interaction of individuals, organizations, projects etc. with their environmental context.

    Macrocultures: refer to the shared beliefs, norms values rules and practices with in inter- organizational networks that guide members on their actions.

    A qualitative approach using a multiple comparative case study was conducted. Accordingly four projects chosen from creative industries were studied using both primary and secondary data.

    Macrocultures that are embedded inter-organizational networks facilitate coordination within inter-organizational projects. Further projects that differ in their constituents task nature, time duration and team composition relied on different types of embeddedness for coordination.

  • 187.
    Abednazari, Hossein
    et al.
    Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
    Xu, Junyang
    Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
    Millinger, Eva
    Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Respiratory Medicine. Linköping University, Faculty of Health Sciences.
    Brudin, Lars
    Department of Clinical Physiology, County Hospital, Kalmar, Sweden.
    Forsberg, Pia
    Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
    Nayeri, Fariba
    Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
    Hepatocyte growth factor is a better indicator of therapeutic response than C-reactive protein within the first day of treatment in pneumonia2006In: Chemotherapy, ISSN 0009-3157, E-ISSN 1421-9794, Vol. 52, no 5, p. 260-263Article in journal (Refereed)
    Abstract [en]

    Acute bacterial infectious diseases are mostly treated empirically at admission before the culture results are available. According to the risk for serious complications in the case of therapeutic failure, it is important to evaluate the therapy results and change to a more appropriate antibiotic regime as soon as possible. In the present study, 40 patients with X-ray-verified community-acquired pneumonia were examined and blood specimens were collected before and within 24 h of treatment. Body temperature, C-reactive protein (CRP) and hepatocyte growth factor (HGF) were investigated. Thirty-two patients received an appropriate initial antibiotic therapy regarding clinical outcome, but in 8 patients the treatment was changed because of therapy failure. Changes of HGF levels after 18–24 h of treatment could predict the therapeutic results accurately in 38 of 40 cases (sensitivity 100%, specificity 94%, positive likelihood ratio 16.0). HGF was significantly better to predict therapy outcome than CRP (p < 0.0001).

  • 188.
    Abednazari, Hossin
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. PEAS Institute, Linköping.
    Brudin, Lars
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
    Almroth, Gabriel
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
    Nilsson, Ingela
    Kalmar County Hospital, Sweden.
    Nayeri, Fariba
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Infectious Diseases.
    Hepatocyte growth factor is a reliable marker for efficient anti-bacterial therapy within the first day of treatment2014In: Advances in Bioscience and Biotechnology, ISSN 2156-8456, E-ISSN 2156-8502, Vol. 5, no 10, p. 823-830Article in journal (Refereed)
    Abstract [en]

    Rapid diagnosis and choice of appropriate antibiotic treatment might be life-saving in serious infectious diseases. Still the available markers that can evaluate and monitor the diagnosis and treatment are few. Hepatocyte growth factor (HGF) has been studied as a potent regenerative factor produced and released during injuries such as infectious diseases. Monitoring of HGF levels might predict therapy results better than C-reactive protein (CRP) within the first day of treatment in pneumonia. For further investigation of previous observations we aimed to study HGF as a first-day marker in over-representing infectious diseases in comparison to procalcitonin (PCT), CRP and body temperature. Fifty-one patients with community acquired infectious diseases were included consequently at admittance and the serum samples were collected before and within 18 - 24 hours of treatment. HGF levels decreased significantly in case of efficient antibiotic therapy and HGF was shown to be better than PCT, CRP and body temperature to evaluate treatment. In patients with pneumonia, monitoring of HGF was most reasonable. HGF might be used as a therapeutic marker within the first day of empiric antibiotic treatment during infection.

  • 189.
    Abela, Charles
    Linköping University, Department of Behavioural Sciences and Learning.
    Understanding the Dynamics of the Employability Agenda in Further Education Colleges in England: New Cross College - A Case Study2008Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study explores the dynamic of what happens within a further education college in order to develop an understanding of the cultures, systems and processes that are used to socially construct meaning around work and employability.  It is an inductive approach and is based on a case study of a further education college in South London.  The case study is analysed through the metaphor of an “extended family” and draws on social learning theory which is predicated on meaning and identity being created through social interaction (Wenger, 1998).  What has become apparent from being immersed within that extended family of the College, from interviews with staff and students, interacting in social activities, observing classes and reviewing many of its artefacts is perhaps an unremarkable conclusion.  The work of the family is not primarily about imparting a given set of skills (although that plays an important part) but in the formation of identity: “because learning transforms who we are and what we can do, it is an experience of identity” (Wenger, 1998, p. 215).  A major task for the College is to build self belief in developing the identity of learners and assist them to make new meaning so that they can transact effectively in economic life.  To the extent that one can examine and comprehend the organisational DNA of a further education college there are markers here, genes if you will, that can be passed across generations of learners that adapt and shift to survive in life beyond the boundaries of this community.  This study constructs a narrative around that research experience to respond to that primary research question about how the dynamics of the employability operate within a college.  The answer is partial, limited and perhaps only grabs at a corner of what is really going on within the College.  With those caveats and disclaimers what follows is the story of how a discourse takes root and flourishes within a learning community.  It points to the need to re-set the relationship between FE colleges and government to promote greater coherence between policy and practice.

  • 190.
    Abelius, M
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    Berg, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
    Matthiesen, Leif
    Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
    Nilsson, L J
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
    Immunological interactions between mother and child: a characterisation of Th1-and Th2-like chemokines during pregnancy, postpartum and childhood in JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 90, issue 2, pp 170-1712011In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Elsevier , 2011, Vol. 90, no 2, p. 170-171Conference paper (Refereed)
    Abstract [en]

    n/a

  • 191.
    Abelius, Martina
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background: Pregnancy and allergic disease have both been postulated as T-helper 2 (Th2) phenomena. Thus, the increased propensity of allergic mothers to mount Th2-responses might generate favourable effects on the maintenance of pregnancy, but might also be unfavorable, as fetal exposure to a strong Th2 environment could influence the immune development in the offspring to a Th2-like phenotype, favouring IgE production and possibly allergy development later in life. The influence of the intrauterine environment on the immunity and allergy development in the offspring needs to be further investigated.

    Aim: The aim of this thesis was to explore the Th1/Th2 balance in allergic and non-allergic women during pregnancy and its influence on the shaping of the Th1/Th2 profile in the neonate and the development of allergic diseases in the offspring.

    Material and methods: The study group included 20 women with and 36 women without allergic symptoms followed during pregnancy (gestational week 10-12, 15-16, 25, 35, 39) and 2 and 12 months postpartum, and their children followed from birth to 6 years of age. The circulating Th1-like chemokines CXCL9, CXCL10, CXCL11, Th2-like chemokines CCL17, CCL18 and CCL22, and the allergen-induced secretion of interleukin-4 (IL-4), IL-5, IL-10, IL-13, Interferon-γ (IFN-γ), CXCL10 and CCL17 were measured by Luminex and ELISA. The allergen-specific and total IgE levels were quantified using ImmunoCAP Technology. mRNA expression of Th1-, Th2-, Treg- and Th17-associated genes were measured by PCR arrays and real-time PCR.

    Results: We found that sensitised women with allergic symptoms had increased total IgE levels and birch- and cat-induced IL-5, IL-13 and CCL17 responses during pregnancy as compared with postpartum. The non-sensitised women without allergic symptoms had elevated cat-induced IL-5 and IL-13 responses and lower birch- and cat-induced IFN-γ during pregnancy, but similar IgE levels as compared with postpartum.

    Maternal total IgE levels during and after pregnancy correlated with cord blood (CB) IgE and CCL22 levels (regardless of maternal allergy status). Circulating CXCL11, CCL18 and CCL22 levels during pregnancy and postpartum correlated with the corresponding chemokine levels in the offspring at various time points during childhood. Maternal IL-5 expression in peripheral blood mononuclear cells (PBMC) was associated with neonatal Galectin-1, and placental p35 expression was negatively associated with neonatal Tbx21 expression. Increased mRNA expression of CCL22 in cord blood mononuclear cells (CBMC), and increased CCL17 and CCL22 levels in CB were observed in children later developing allergic symptoms and sensitisation as compared with children who did not. Development of allergic symptoms and sensitisation were associated with increased total IgE, CCL17, CCL18 and CCL22 levels during childhood.

    Conclusions: Maternal allergy was associated with a pronounced Th2 deviation during pregnancy, shown as increased total IgE levels and birch- and cat-induced IL-5, IL-13 and CCL17 responses during pregnancy, possibly exposing their fetuses to a particular strong Th2 environment during gestation.

    Correlations were shown between the maternal immunity during pregnancy and the offspring’s immunity at birth and later during childhood, indicating an interplay between the maternal and fetal immunity.

    Allergy development during the first 6 years of life was associated with a marked Th2 deviation at birth and a delayed down-regulation of this Th2-skewed immunity during childhood.

    List of papers
    1. Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy
    Open this publication in new window or tab >>Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy
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    2009 (English)In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ISSN 0165-0378, Vol. 81, no 1, p. 82-88Article in journal (Refereed) Published
    Abstract [en]

    Type 2 T-helper cell (Th2)-skewed immunity is associated with successful pregnancy and the ability to easily direct immune responses to a Th2-polarised profile may be an evolutionary benefit. The Th2-like immunity associated with allergic disease might generate favourable effects for the maintenance of pregnancy, but could also promote development of Th2-like immune responses and allergic disease in the offspring. The aim of this study was to explore, by using IgE as a stable proxy for Th2, the Th1/Th2 balance in allergic and non-allergic women by measuring allergen-specific and total IgE antibody levels in plasma during pregnancy and after delivery. Specific and total IgE antibody levels were determined by ImmunoCAP technology at five occasions during pregnancy (gestational weeks 10-12, 15-16, 25, 35 and 39), as well as at 2 and 12 months after delivery. Thirty-six women without and 20 women with allergic symptoms were included, of whom 13 were sensitised with allergic symptoms and 30 were non-sensitised without allergic symptoms. The levels of total IgE, but not allergen-specific IgE, were increased during early pregnancy when compared to 12 months after delivery in the sensitised women with allergic symptoms, but not in the non-sensitised women without allergic symptoms (pandlt;0.01). This increase in total IgE levels during early pregnancy only in the sensitised women with allergic symptoms indicates that allergy is associated with an enhanced Th2 deviation during pregnancy.

    Keywords
    Allergy, IgE, Phadiatop, Pregnancy, Th2
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-19894 (URN)10.1016/j.jri.2009.04.003 (DOI)
    Note

    Original Publication: Martina Sandberg, Anne Frykman, Yvonne Jonsson, Marie Persson, Jan Ernerudh, Göran Berg, Leif Matthiesen, Christina Ekerfelt and Maria Jenmalm, Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy, 2009, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, (81), 1, 82-88. http://dx.doi.org/10.1016/j.jri.2009.04.003 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/

    Available from: 2009-09-09 Created: 2009-08-14 Last updated: 2014-04-29Bibliographically approved
    2. High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life
    Open this publication in new window or tab >>High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life
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    2011 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 70, no 5, p. 495-500Article in journal (Refereed) Published
    Abstract [en]

    Exposure to a strong T-helper 2 (Th2)-like environment during fetal development may promote allergy development. Increased cord blood (CB) levels of the Th2-associated chemokine CCL22 were associated with allergy development during the first 2 y of life. The aim of the present study was to determine whether CB Th1- and Th2-associated chemokine levels are associated with allergy development during the first 6 y of life, allowing assessment of respiratory allergic symptoms usually developing in this period. The CB levels of cytokines, chemokines, and total IgE were determined in 56 children of 20 women with allergic symptoms and 36 women without allergic symptoms. Total IgE and allergen-specific IgE antibody levels were quantified at 6, 12, 24 mo, and 6 y of age. Increased CB CCL22 levels were associated with development of allergic sensitization and asthma and increased CCL17 levels with development of allergic symptoms, including asthma. Sensitized children with allergic symptoms showed higher CB CCL17 and CCL22 levels and higher ratios between these Th2-associated chemokines and the Th1-associated chemokine CXCL10 than nonsensitized children without allergic symptoms. A pronounced Th2 deviation at birth, reflected by increased CB CCL17 and CCL22 levels, and increased CCL22/CXCL10 and CCL17/CXCL10 ratios might promote allergy development later in life.

    Keywords
    AD, atopic dermatitis, ARC, allergic rhinoconjunctivitis, CB, cord blood, SPT, skin prick test, Th, T-helper
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-74499 (URN)10.1203/PDR.0b013e31822f2411 (DOI)000296121100010 ()21796021 (PubMedID)
    Available from: 2012-01-30 Created: 2012-01-30 Last updated: 2017-12-08
    3. Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy
    Open this publication in new window or tab >>Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy
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    2014 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 25, no 4, p. 387-393Article in journal (Refereed) Published
    Abstract [en]

    Background: The influence of the intra-uterine environment on the immunity and allergy development in the offspring is unclear. We aimed to investigate (i) whether the pregnancy magnifies the Th2 immunity in allergic and non-allergic women, (ii) whether the maternal chemokine levels during pregnancy influenced the offspring’s chemokine levels during childhood and (iii) the relationship between circulating Th1/Th2-associated chemokines and allergy in mothers and children.

    Methods: The Th1-associated chemokines CXCL9, CXCL10, CXCL11, and the Th2- associated chemokines CCL17, CCL18 and CCL22 were quantified by Luminex and ELISA in 20 women with and 36 women without allergic symptoms at gestational week (gw) 10–12, 15–16, 25, 35, 39 and 2 and 12 months post-partum and in their children at birth, 6, 12, 24 months and 6 yr of age. Total IgE levels were measured using ImmunoCAP Technology.

    Results: The levels of the Th2-like chemokines were not magnified by pregnancy. Instead decreased levels were shown during pregnancy (irrespectively of maternal allergy status) as compared to post-partum. In the whole group, the Th1-like chemokine levels were higher at gw 39 than during the first and second trimester and post-partum. Maternal CXCL11, CCL18 and CCL22 levels during and after pregnancy correlated with the corresponding chemokines in the offspring during childhood. Increased CCL22 and decreased CXCL10 levels in the children were associated with sensitisation and increased CCL17 levels with allergic symptoms during childhood. Maternal chemokine levels were not associated with maternal allergic disease.

    Conclusions: Allergic symptoms and sensitisation were associated with decreased Th1-and increased Th2-associated chemokine levels during childhood, indicating a Th2 shift in the allergic children, possibly influenced by the maternal immunity during pregnancy.

    Place, publisher, year, edition, pages
    John Wiley & Sons, 2014
    Keywords
    Allergy; CCL17; CCL22; chemokines; pregnancy; Th2
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-106218 (URN)10.1111/pai.12235 (DOI)000338037100013 ()
    Available from: 2014-04-29 Created: 2014-04-29 Last updated: 2017-12-05Bibliographically approved
    4. Gene expression in placenta, peripheral and cord blood mononuclear cells from allergic and non-allergic women
    Open this publication in new window or tab >>Gene expression in placenta, peripheral and cord blood mononuclear cells from allergic and non-allergic women
    Show others...
    2014 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: The influence of maternal allergy on the development of immune responses and allergy in the offspring is not understood.

    Objective: To investigate (i) if maternal allergy influences the gene expression locally in placenta, systemically in peripheral blood mononuclear cells (PBMC) and fetally in cord blood mononuclear cells (CBMC), (ii) if the gene expression in the placenta and PBMC influences the gene expression in CBMC and (iii) how the gene expression at birth relates to allergy development during  childhood.

    Methods: A real-time PCR array was used to quantify forty immune regulatory genes in placenta, PBMC (gestational week 39) and in CBMC from 7 allergic and 12 non-allergic women and their offspring. Furthermore, quantitative real-time PCR was used to measure mRNA expression of Tbx21, GATA-3, Foxp3, RORC and CCL22 in CBMC, selected based on present PCR array results and previous protein findings in cord blood, in 13 children who developed and 11 children who did not develop allergy during childhood.

    Results: The gene expression profile in the placenta revealed a T-helper (Th) 2-/anti-inflammatory environment as compared with gene expression systemically, in PBMC. Maternal allergy was associated with increased expression of p35 in PBMC and CBMC and p40 in placenta. Placental p35 expression correlated with fetal Tbx21 expression (Rho=-0.88, p<0.001) and maternal IL-5 expression in PBMC with fetal Galectin-1 (Rho=0.91, p<0.001) expression. Allergy development in the children was preceded by high mRNA expression of the Th2-associated chemokine CCL22 at birth.

    Conclusion and clinical relevance: Gene expression locally and systemically during pregnancy influenced the offspring’s gene expression at birth, indicating an interplay between maternal and fetal immunity. Children developing allergy during childhood had an increased expression of the Th2-associated chemokine CCL22 at birth, indicating a Th2 skewing before disease onset. Maternal allergy was not associated with a Th2-dominance in placenta, PBMC or CBMC.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-106219 (URN)
    Available from: 2014-04-29 Created: 2014-04-29 Last updated: 2015-03-25Bibliographically approved
  • 192.
    Abelius, Martina
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Enke, Uta
    University Hospital Jena, Germany.
    Varosi, Frauke
    University Hospital Jena, Germany.
    Hoyer, Heike
    University Hospital Jena, Germany.
    Schleussner, Ekkehard
    University Hospital Jena, Germany.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Markert, Udo R.
    University Hospital Jena, Germany.
    Placental immune response to apple allergen in allergic mothers2014In: Journal of Reproductive Immunology, ISSN 0165-0378, E-ISSN 1872-7603, Vol. 106, p. 100-109Article in journal (Refereed)
    Abstract [en]

    The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero, but little is known about allergen-induced placental cytokine and chemokine release. The release of several cytokines and chemokines from placenta tissue after exposure to mast cell degranulator compound 48/80 or apple allergen in placentas from allergic and healthy mothers was to be analysed. Four placentas from women with apple allergy and three controls were applied in a placental perfusion model with two separate cotyledons simultaneously perfused with and without apple allergen (Mal d 1). Two control placentas were perfused with compound 48/80. In outflow, histamine was quantified spectrophotofluorometrically, IL-2, IL-4, IL-6, IL-10, TNF and IFN-gamma by a cytometric multiplex bead array and IL-13 and CXCL10, CXCL11, CCL17 and CCL22 with an in-house multiplex Luminex assay. Compound 48/80 induced a rapid release of histamine, CXCL10, CXCL11, CCL17 and CCL22, but not of the other factors. Apple allergen induced a time-dependent release of IL-6 and TNF, but not of histamine, in placentas of women with apple allergy compared with the unstimulated cotyledon. CCL17 levels were slightly increased after allergen stimulation in control placentas. Allergens can induce placental cytokines and chemokines distinctly in allergic and healthy mothers. These mediators may affect the prenatal development of the immune system and modify the risk of diseases related to immune disorders in childhood such as allergies.

  • 193.
    Abelius, Martina
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Jedenfalk, Malin
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    Janefjord, Camilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Berg, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Matthiesen, Leif
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping. Helsingborg Hospital, Sweden.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Pregnancy modulates the allergen-induced cytokine production differently in allergic and non-allergic women2017In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 28, no 8, p. 818-824Article in journal (Refereed)
    Abstract [en]

    Background: The immunological environment during pregnancy may differ between allergic and non-allergic women. This study investigates the effect of maternal allergy on the allergen-induced cytokine and chemokine levels and whether pregnancy modulates these immune responses differently in allergic and non-allergic women. Methods: The birch-, cat-, phytohemagglutinin- and tetanus toxoid-induced interferon-gamma(IFN-gamma), interleukin (IL)-4, IL-5, IL-10, IL-13, the T-helper 1 (Th1)-associated chemokine CXCL10 and the Th2-associated chemokine CCL17 levels were quantified in 20 women with allergic symptoms (sensitized, n=13) and 36 women without allergic symptoms (non-sensitized, n=30) at gestational weeks 10-12, 15-16, 25, 35 and 2 and 12months post-partum. Results: Birch-, but not cat-induced, IL-5, IL-13 and CCL17 levels were increased during pregnancy as compared to post-partum in the sensitized women with allergic symptoms. In contrast, cat-, but not birch-induced, IL-5 and IL-13 levels were increased during pregnancy as compared to post-partum in the non-sensitized women without allergic symptoms. Furthermore, IFN-gamma secretion was increased in the first and decreased in the second and third trimesters in response to birch and decreased in the third trimester in response to cat as compared to post-partum in the non-sensitized women without allergic symptoms. Increased allergen-induced IL-4, IL-5 and IL-13 levels were associated with allergic symptoms and sensitization. Conclusions: Pregnancy had a clear effect on the allergen-induced IL-5, IL-13, CCL17, IFN-gamma and CXCL10 production, with distinct enhanced Th2-responses to birch in the allergic group and to cat in the non-allergic group.

  • 194.
    Abelius, Martina S
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    Berg, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
    Matthiesen, Leif
    Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
    Nilsson, Lennart
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
    High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life2011In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 70, no 5, p. 495-500Article in journal (Refereed)
    Abstract [en]

    Exposure to a strong T-helper 2 (Th2)-like environment during fetal development may promote allergy development. Increased cord blood (CB) levels of the Th2-associated chemokine CCL22 were associated with allergy development during the first 2 y of life. The aim of the present study was to determine whether CB Th1- and Th2-associated chemokine levels are associated with allergy development during the first 6 y of life, allowing assessment of respiratory allergic symptoms usually developing in this period. The CB levels of cytokines, chemokines, and total IgE were determined in 56 children of 20 women with allergic symptoms and 36 women without allergic symptoms. Total IgE and allergen-specific IgE antibody levels were quantified at 6, 12, 24 mo, and 6 y of age. Increased CB CCL22 levels were associated with development of allergic sensitization and asthma and increased CCL17 levels with development of allergic symptoms, including asthma. Sensitized children with allergic symptoms showed higher CB CCL17 and CCL22 levels and higher ratios between these Th2-associated chemokines and the Th1-associated chemokine CXCL10 than nonsensitized children without allergic symptoms. A pronounced Th2 deviation at birth, reflected by increased CB CCL17 and CCL22 levels, and increased CCL22/CXCL10 and CCL17/CXCL10 ratios might promote allergy development later in life.

  • 195.
    Abelius, Martina S
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Janefjord, Camilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    Berg, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Matthiesen, Leif
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping. Helsingborg Hospital, Helsingborg.
    Duchén, Karel
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    Nilsson, Lennart J
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Allergy Center.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    The Placental Immune Milieu is Characterized by a Th2- and Anti-Inflammatory Transcription Profile, Regardless of Maternal Allergy, and Associates with Neonatal Immunity2015In: American Journal of Reproductive Immunology, ISSN 1046-7408, E-ISSN 1600-0897, Vol. 73, no 5, p. 445-459Article in journal (Refereed)
    Abstract [en]

    PROBLEM: How maternal allergy affects the systemic and local immunological environment during pregnancy and the immune development of the offspring is unclear.

    METHOD OF STUDY: Expression of 40 genes was quantified by PCR arrays in placenta, peripheral blood mononuclear cells (PBMC), and cord blood mononuclear cells (CBMC) from 7 allergic and 12 non-allergic women and their offspring.

    RESULTS: Placental gene expression was dominated by a Th2-/anti-inflammatory profile, irrespectively of maternal allergy, as compared to gene expression in PBMC. p35 expression in placenta correlated with fetal Tbx21 (ρ = -0.88, P < 0.001) and IL-5 expression in PBMC with fetal galectin1 (ρ = 0.91, P < 0.001). Increased expression of Th2-associated CCL22 in CBMC preceded allergy development.

    CONCLUSIONS: Gene expression locally and systemically during pregnancy was partly associated with the offspring's gene expression, possibly indicating that the immunological milieu is important for fetal immune development. Maternal allergy was not associated with an enhanced Th2 immunity in placenta or PBMC, while a marked prenatal Th2 skewing, shown as increased CCL22 mRNA expression, might contribute to postnatal allergy development.

  • 196.
    Abelius, Martina S
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Janefjord, Camilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    Berg, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Matthiesen, Leif
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Duchén, Karel
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Nilsson, Lennart
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Allergy Center.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Gene expression in placenta, peripheral and cord blood mononuclear cells from allergic and non-allergic women2014Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: The influence of maternal allergy on the development of immune responses and allergy in the offspring is not understood.

    Objective: To investigate (i) if maternal allergy influences the gene expression locally in placenta, systemically in peripheral blood mononuclear cells (PBMC) and fetally in cord blood mononuclear cells (CBMC), (ii) if the gene expression in the placenta and PBMC influences the gene expression in CBMC and (iii) how the gene expression at birth relates to allergy development during  childhood.

    Methods: A real-time PCR array was used to quantify forty immune regulatory genes in placenta, PBMC (gestational week 39) and in CBMC from 7 allergic and 12 non-allergic women and their offspring. Furthermore, quantitative real-time PCR was used to measure mRNA expression of Tbx21, GATA-3, Foxp3, RORC and CCL22 in CBMC, selected based on present PCR array results and previous protein findings in cord blood, in 13 children who developed and 11 children who did not develop allergy during childhood.

    Results: The gene expression profile in the placenta revealed a T-helper (Th) 2-/anti-inflammatory environment as compared with gene expression systemically, in PBMC. Maternal allergy was associated with increased expression of p35 in PBMC and CBMC and p40 in placenta. Placental p35 expression correlated with fetal Tbx21 expression (Rho=-0.88, p<0.001) and maternal IL-5 expression in PBMC with fetal Galectin-1 (Rho=0.91, p<0.001) expression. Allergy development in the children was preceded by high mRNA expression of the Th2-associated chemokine CCL22 at birth.

    Conclusion and clinical relevance: Gene expression locally and systemically during pregnancy influenced the offspring’s gene expression at birth, indicating an interplay between maternal and fetal immunity. Children developing allergy during childhood had an increased expression of the Th2-associated chemokine CCL22 at birth, indicating a Th2 skewing before disease onset. Maternal allergy was not associated with a Th2-dominance in placenta, PBMC or CBMC.

  • 197.
    Abelius, Martina S
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Lempinen, Esma
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Lindblad, Karin
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Ernerudh, Jan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
    Berg, Göran
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Matthiesen, Leif
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Nilsson, Lennart
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Allergy Center.
    Jenmalm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy2014In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 25, no 4, p. 387-393Article in journal (Refereed)
    Abstract [en]

    Background: The influence of the intra-uterine environment on the immunity and allergy development in the offspring is unclear. We aimed to investigate (i) whether the pregnancy magnifies the Th2 immunity in allergic and non-allergic women, (ii) whether the maternal chemokine levels during pregnancy influenced the offspring’s chemokine levels during childhood and (iii) the relationship between circulating Th1/Th2-associated chemokines and allergy in mothers and children.

    Methods: The Th1-associated chemokines CXCL9, CXCL10, CXCL11, and the Th2- associated chemokines CCL17, CCL18 and CCL22 were quantified by Luminex and ELISA in 20 women with and 36 women without allergic symptoms at gestational week (gw) 10–12, 15–16, 25, 35, 39 and 2 and 12 months post-partum and in their children at birth, 6, 12, 24 months and 6 yr of age. Total IgE levels were measured using ImmunoCAP Technology.

    Results: The levels of the Th2-like chemokines were not magnified by pregnancy. Instead decreased levels were shown during pregnancy (irrespectively of maternal allergy status) as compared to post-partum. In the whole group, the Th1-like chemokine levels were higher at gw 39 than during the first and second trimester and post-partum. Maternal CXCL11, CCL18 and CCL22 levels during and after pregnancy correlated with the corresponding chemokines in the offspring during childhood. Increased CCL22 and decreased CXCL10 levels in the children were associated with sensitisation and increased CCL17 levels with allergic symptoms during childhood. Maternal chemokine levels were not associated with maternal allergic disease.

    Conclusions: Allergic symptoms and sensitisation were associated with decreased Th1-and increased Th2-associated chemokine levels during childhood, indicating a Th2 shift in the allergic children, possibly influenced by the maternal immunity during pregnancy.

  • 198.
    Abellán, C.
    et al.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Acín, A.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain / ICREA - Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
    Alarcón, A.
    Millennium Institute for Research in Optics, Universidad de Concepción, Universidad de Concepción, Concepción, Chile / Departamento de Ingeniería Eléctrica, Universidad de Concepción, Concepción, Chile.
    Alibart, O.
    Université Côte d’Azur, CNRS UMR 7010, Institut de Physique de Nice (INPHYNI), Nice, France.
    Andersen, C. K.
    Department of Physics, ETH Zurich,, Zurich, Switzerland.
    Andreoli, F.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Beckert, A.
    Department of Physics, ETH Zurich,, Zurich, Switzerland.
    Beduini, F. A.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Bendersky, A.
    Departamento de Computación, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Investigación en Ciencias de la Comunicación (ICC), CONICET, Buenos Aires, Argentina.
    Bentivegna, M.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Bierhorst, P.
    National Institute of Standards and Technology, Boulder, CO, USA.
    Burchardt, D.
    Ludwig-Maximilians-Universität, Munich, Germany.
    Cabello, A.
    Departamento de Física Aplicada II, Universidad de Sevilla, Seville, Spain.
    Cariñe, J.
    Millennium Institute for Research in Optics, Universidad de Concepción, Universidad de Concepción, Concepción, Chile.
    Carrasco, S.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Carvacho, G.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Cavalcanti, D.
    Chaves, R.
    Cortés-Vega, J.
    Cuevas, A.
    Delgado, A.
    de Riedmatten, H.
    Eichler, C.
    Farrera, P.
    Fuenzalida, J.
    García-Matos, M.
    Garthoff, R.
    Gasparinetti, S.
    Gerrits, T.
    Ghafari Jouneghani, F.
    Glancy, S.
    Gómez, E. S.
    González, P.
    Guan, J. -Y.
    Handsteiner, J.
    Heinsoo, J.
    Heintze, G.
    Hirschmann, A.
    Jiménez, O.
    Kaiser, F.
    Knill, E.
    Knoll, L. T.
    Krinner, S.
    Kurpiers, P.
    Larotonda, M. A.
    Larsson, Jan-Åke
    Linköping University, Department of Electrical Engineering, Information Coding. Linköping University, Faculty of Science & Engineering.
    Lenhard, A.
    Li, H.
    Li, M. -H.
    Lima, G.
    Liu, B.
    Liu, Y.
    López Grande, I. H.
    Lunghi, T.
    Ma, X.
    Magaña-Loaiza, O. S.
    Magnard, P.
    Magnoni, A.
    Martí­-Prieto, M.
    Martínez, D.
    Mataloni, P.
    Mattar, A.
    Mazzera, M.
    Mirin, R. P.
    Mitchell, M. W.
    Nam, S.
    Oppliger, M.
    Pan, J. -W.
    Patel, R. B.
    Pryde, G. J.
    Rauch, D.
    Redeker, K.
    Rieländer, D.
    Ringbauer, M.
    Roberson, T.
    Rosenfeld, W.
    Salathé, Y.
    Santodonato, L.
    Sauder, G.
    Scheidl, T.
    Schmiegelow, C. T.
    Sciarrino, F.
    Seri, A.
    Shalm, L. K.
    Shi, S. -C
    Slussarenko, S.
    Stevens, M. J.
    Tanzilli, S.
    Toledo, F.
    Tura, J.
    Ursin, R.
    Vergyris, P.
    Verma, V. B.
    Walter, T.
    Wallraff, A.
    Wang, Z.
    Weinfurter, H.
    Weston, M. M.
    White, A. G.
    Wu, C.
    Xavier, Guilherme B.
    Linköping University, Department of Electrical Engineering, Information Coding. Linköping University, Faculty of Science & Engineering.
    You, L.
    Yuan, X.
    Zeilinger, A.
    Zhang, Q.
    Zhang, W.
    Zhong, J.
    Challenging Local Realism with Human Choices2018In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 557, p. 212-216Article in journal (Refereed)
    Abstract [en]

    A Bell test is a randomized trial that compares experimental observations against the philosophical worldview of local realism , in which the properties of the physical world are independent of our observation of them and no signal travels faster than light. A Bell test requires spatially distributed entanglement, fast and high-efficiency detection and unpredictable measurement settings. Although technology can satisfy the first two of these requirements, the use of physical devices to choose settings in a Bell test involves making assumptions about the physics that one aims to test. Bell himself noted this weakness in using physical setting choices and argued that human ‘free will’ could be used rigorously to ensure unpredictability in Bell tests. Here we report a set of local-realism tests using human choices, which avoids assumptions about predictability in physics. We recruited about 100,000 human participants to play an online video game that incentivizes fast, sustained input of unpredictable selections and illustrates Bell-test methodology. The participants generated 97,347,490 binary choices, which were directed via a scalable web platform to 12 laboratories on five continents, where 13 experiments tested local realism using photons, single atoms, atomic ensembles and superconducting devices. Over a 12-hour period on 30 November 2016, participants worldwide provided a sustained data flow of over 1,000 bits per second to the experiments, which used different human-generated data to choose each measurement setting. The observed correlations strongly contradict local realism and other realistic positions in bi-partite and tri-partite 12 scenarios. Project outcomes include closing the ‘freedom-of-choice loophole’ (the possibility that the setting choices are influenced by ‘hidden variables’ to correlate with the particle properties), the utilization of video-game methods for rapid collection of human-generated randomness, and the use of networking techniques for global participation in experimental science.

  • 199.
    Abelow, Alexis
    et al.
    University of Utah, Salt Lake City, USA.
    Persson, Kristin
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Jager, Edwin
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
    Berggren, Magnus
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Zharov, Ilya
    University of Utah, Salt Lake City, USA.
    Electroresponsive Nanoporous Membranes by Coating Anodized Alumina with Poly(3,4-ethylenedioxythiophone) and Polypyrrole2014In: Macromolecular materials and engineering (Print), ISSN 1438-7492, E-ISSN 1439-2054, Vol. 299, no 2, p. 190-197Article in journal (Refereed)
    Abstract [en]

    Electrically-active nanoporous membranes are prepared by coating the surface of anodized alumina with electroactive polymers using vapor phase polymerization with four combinations of conjugated polymers and doping ions: poly(3,4-ethylenedioxythiophone) and polypyrrole, FeCl3 and FeTs3. The permeability of the polymer-coated membranes is measured as a function of the applied electric potential. A reversible three-fold increase is found in molecular flux of a neutral dye for membranes in oxidized state compared to that in the reduced state. After analyzing various factors that may affect the molecular transport through these membranes, it is concluded that the observed behavior results mostly from swelling/deswelling of the polymers and from the confinement of the polymers inside the nanopores.

  • 200.
    Abelsson, J.
    et al.
    NU Hospital Organization, Uddevalla.
    Merup, M.
    Karolinska Universitetssjukhuset, Huddinge.
    Birgegård, G.
    Uppsala University.
    WeisBjerrum, O.
    Rigshospitalet, University of Copenhagen.
    Brinch, L.
    Rikshospitalet, Oslo University Hospital.
    Brune, M.
    Sahlgrenska Universitetssjukhuset, Göteborg.
    Johansson, P.
    NU Hospital Organization, Uddevalla.
    Kauppila, M.
    Turku University Hospital, Finland.
    Lenhoff, S.
    Skåne University Hospital.
    Liljeholm, M.
    Norrlands Universitetssjukhus, Umeå.
    Malm, Claes
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology UHL.
    Remes, K.
    Turku University Hospital, Finland.
    Vindelöv, L.
    Rigshospitalet, University of Copenhagen.
    Andréasson, Björn
    NU Hospital Organization, Uddevalla.
    The outcome of allo-HSCT for 92 patients with myelofibrosis in the Nordic countries2012In: Bone Marrow Transplantation, ISSN 0268-3369, E-ISSN 1476-5365, Vol. 47, no 3, p. 380-386Article in journal (Refereed)
    Abstract [en]

    Between 1982 and 2009 a total of 92 patients with myelofibrosis (MF) in chronic phase underwent allo-SCT in nine Nordic transplant centers. Myeloablative conditioning (MAC) was given to 40 patients, and reduced intensity conditioning (RIC) was used in 52 patients. The mean age in the two groups at transplantation was 46±12 and 55±8 years, respectively (P<0.001). When adjustment for age differences was made, the survival of the patients treated with RIC was significantly better (P=0.003). Among the RIC patients, the survival was significantly (P=0.003) better for the patients with age <60 years (a 10-year survival close to 80%) than for the older patients. The type of stem cell donor did not significantly affect the survival. No significant difference was found in TRM at 100 days between the MAC- and the RIC-treated patients. The probability of survival at 5 years was 49% for the MAC-treated patients and 59% in the RIC group (P=0.125). Patients treated with RIC experienced significantly less aGVHD compared with patients treated with MAC (P<0.001). The OS at 5 years was 70, 59 and 41% for patients with Lille score 0, 1 and 2, respectively (P=0.038, when age adjustment was made). Twenty-one percent of the patients in the RIC group were given donor lymphocyte infusion because of incomplete donor chimerism, compared with none of the MAC-treated patients (P<0.002). Nine percent of the patients needed a second transplant because of graft failure, progressive disease or transformation to AML, with no significant difference between the groups. Our conclusions are (1) allo-SCT performed with RIC gives a better survival compared with MAC. (2) age over 60 years is strongly related to a worse outcome and (3) patients with higher Lille score had a shorter survival.Bone Marrow Transplantation advance online publication, 9 May 2011; doi:10.1038/bmt.2011.91.

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