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  • 201.
    Aboulaich, Nabila
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Vainonen, Julia P
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Strålfors, Peter
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Vener, Alexander V
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes2004In: The Biochemical journal, ISSN 1470-8728, Vol. 383, no Pt 2, p. 237-248Article in journal (Refereed)
    Abstract [en]

    Caveolae, the specialized invaginations of plasma membranes, formed sealed vesicles with outwards-orientated cytosolic surface after isolation from primary human adipocytes. This morphology allowed differential, vectorial identification of proteins at the opposite membrane surfaces by proteolysis and MS. Extracellular-exposed caveolae-specific proteins CD36 and copper-containing amine oxidase were concealed inside the vesicles and resisted trypsin treatment. The cytosol-orientated caveolins were efficiently digested by trypsin, producing peptides amenable to direct MS sequencing. Isolation of peripheral proteins associated with the cytosolic surface of caveolae revealed a set of proteins that contained nuclear localization signals, leucine-zipper domains and PEST (amino acid sequence enriched in proline, glutamic acid, serine and threonine) domains implicated in regulation by proteolysis. In particular, PTRF (polymerase I and transcript release factor) was found as a major caveolae-associated protein and its co-localization with caveolin was confirmed by immunofluorescence confocal microscopy. PTRF was present at the surface of caveolae in the intact form and in five different truncated forms. Peptides (44 and 45 amino acids long) comprising both the PEST domains were sequenced by nanospray-quadrupole-time-of-flight MS from the full-length PTRF, but were not found in the truncated forms of the protein. Two endogenous cleavage sites corresponding to calpain specificity were identified in PTRF; one of them was in a PEST domain. Both cleavage sites were flanked by mono- or diphosphorylated sequences. The phosphorylation sites were localized to Ser-36, Ser-40, Ser-365 and Ser-366 in PTRF. Caveolae of human adipocytes are proposed to function in targeting, relocation and proteolytic control of PTRF and other PEST-domain-containing signalling proteins.

  • 202.
    Aboulaich, Nabila
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Vener, Alexander V
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Strålfors, Peter
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes2006In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 281, no 17, p. 11446-11449Article in journal (Refereed)
    Abstract [en]

    In adipocytes, perilipin coats and protects the central lipid droplet, which stores triacylglycerol. Alternative mRNA splicing gives rise to perilipin A and B. Hormones such as catecholamines and insulin regulate triacylglycerol metabolism through reversible serine phosphorylation of perilipin A. It was recently shown that perilipin was also located in triacylglycerol-synthesizing caveolae of the plasma membrane. We now report that perilipin at the plasma membrane of primary human adipocytes was phosphorylated on a cluster of threonine residues (299, 301, and 306) within an acidic domain that forms part of the lipid targeting domain. Perilipin B comprised <10% of total perilipin but was the major isoform associated with the plasma membrane of human adipocytes. This association was controlled by insulin and catecholamine: perilipin B was specifically depleted from the plasma membrane in response to the catecholamine isoproterenol, while insulin increased the amount of threonine phosphorylated perilipin at the plasma membrane. The reversible translocation of perilipin B to and from the plasma membrane in response to insulin and isoproterenol, respectively, suggests a specific function for perilipin B to protect newly synthesized triacylglycerol in the plasma membrane.

  • 203.
    Abouzeedan, Adli
    Linköping University, Department of Management and Engineering. Linköping University, The Institute of Technology.
    SME Performance and Its Relationship to Innovation2011Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Current SME performance models suffer from a number of disadvantages. The models use intensively a business ratio approach, they look at SMEs as a homogenous group, they consider firms to be closed systems, they do not directly incorporate the impact of an enterprise’s innovation activities, and finally they are complex and rely on sophisticated statistical refining methods making them unpractical to use by SME managers. There are four major challenges when one tries to build SME performance models that lack these deficiencies. The first challenge is that the desired performance evaluation model must optimally incorporate both quantitative and qualitative input. The second challenge is that the model must incorporate non-financial input parameters, such as firm size and age (among others), in the performance evaluation models. The third is that the model must consider the variety of SMEs as concerns their business sectors, nationalities, sizes, and ages. The final challenge is that the model must be able to utilize existing limited information available from the SMEs bookkeeping practices in an optimal way.

    The thesis addresses three questions related to constructing a better SMEperformance model, namely (1) What are the advantages and disadvantages of the existing models used in evaluating SME performance? (2) What characterizes a comprehensive model for measuring SME performance with acknowledgement of the firm’s innovation activities? (3) How can a firm’s innovation activities be enhanced in relation to the firm’s external environment?

    To construct a model that copes with these challenges, I used a literature-based selection of parameters as well as a theory-based selection. I used both a conceptual approach and an empirical approach to discuss and propose a model, the Survival Index Value (or SIV) model, as an alternative to the existing performance models for SMEs.

    The major contributions of this thesis to the field of SME performance can be summarized in three outcomes: the SIV model as a new model of SME performance evaluation, the ASPEM as a new tool for strategic utilization of SME performance models, and a new approach to account for innovation in relation to the external environment of the firm using the IBAM tool.

    The work adds to the theory of the firm, as it presents a new way of evaluating firm performance. It also contributes to bridging the theory of the firm to organizational theory, by elevating the significance of networking and its impact on SME efficiency.

    List of papers
    1. Typology Analysis of Performance Models of Small and Medium-Size Enterprises (SMEs)
    Open this publication in new window or tab >>Typology Analysis of Performance Models of Small and Medium-Size Enterprises (SMEs)
    2004 (English)In: International Journal of Entrepreneurship, ISSN 1099-9264, E-ISSN 1939-4675, Vol. 2, no 1-2, p. 155-177Article in journal (Refereed) Published
    Abstract [en]

    A number of firm performance models are available. Reviewing these models and pointing out their individual strengths and weaknesses, would help both academic researchers and professional users to understand and appreciate how and when to use these various models. The theoretical models for Small and Medium-size Enterprise (SME) performance can be divided into two categories: firm dynamics theories and performance prediction models. In the first part of this paper we review, in a condensed manner, the most relevant firm dynamic theories, i.e. SME's performance models. These include: Stochastic Theories, Learning Model Theories and Hazard Modeling Theories. In the second part of this paper, we examine the performance prediction models of SMEs, which include Z-Scores, ZETA-Scores, Neural Networks (NN) and the SIV® models, among others. The strengths and weaknesses of each of these models are exposed and discussed.

    Place, publisher, year, edition, pages
    SpringerLink, 2004
    Keywords
    small and medium-size enterprises - survival index value - SIV® model - Z-scores - neural networks
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71336 (URN)10.1023/B:JIEN.0000026911.03396.2d (DOI)
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2017-12-08Bibliographically approved
    2. ASPEM as the New Topographic Analysis Tool for Small and Medium-Sized Enterprises (SMEs) Performance Models Utilization
    Open this publication in new window or tab >>ASPEM as the New Topographic Analysis Tool for Small and Medium-Sized Enterprises (SMEs) Performance Models Utilization
    2005 (English)In: International Journal of Entrepreneurship, ISSN 1099-9264, E-ISSN 1939-4675, Vol. 3, no 1, p. 53-70Article in journal (Refereed) Published
    Abstract [en]

    Quantifying and measuring small firm performance is vital in our understanding of how internationalization influences firm performance. That is also important when attempting to grasp the mechanisms of the internationalization processes. There are few methods used for the evaluation of performance of Small and Medium-sized Enterprise (SMEs). These methods can be either macro or micro economic in nature. Hazard Modeling, Stochastic Models, and Learning Models are examples of macro economic models while Z-Scores, ZETA-Scores, Neural Networks, and the SIV® model are examples of micro models. Choosing the most suitable performance model is an essential step in order to maximize our knowledge in relation to firm performance. Utilizing SMEs performance measures without thinking about the category of model, will bias the outcome of the majority of SMEs studies. However, using firm performance diverse models in an efficient manner requires strategic thinking. In this paper, we are re-introducing a tool that can accommodate that aspect. Abouzeedan (2002) designated the new tool: the Arena of SMEs Performance Models or an ASPEM diagram. The horizontal axis in the diagram indicates the Information Intensity Requirements of the model. The vertical axis indicates the Coverage Intensity of the model varying from an individual firm up to a whole group of firms. By allocating each of the SMEs performance models, at the suitable region of the ASPEM Diagram, researchers can better build a sound strategy for the application of these methods.

    Place, publisher, year, edition, pages
    SpringerLink, 2005
    Keywords
    Arena of SMEs performance models, ASPEM - SIV® model, Zeta-scores, ZETA-scores, neural networks, stochastic theories, hazard modeling
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71337 (URN)10.1007/s10843-005-0305-4 (DOI)
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2017-12-08Bibliographically approved
    3. Analysis of Swedish Fishery Company Using SIV® Model: A Case Study
    Open this publication in new window or tab >>Analysis of Swedish Fishery Company Using SIV® Model: A Case Study
    2004 (English)In: Journal of Enterprising Culture, ISSN 0218-4958, Vol. 12, no 4, p. 277-301Article in journal (Refereed) Published
    Abstract [en]

    In his original work of the Survival Index Value (SIV®) model, Dr. Adli Abouzeedan proposed a new parameter, which he named as the Survival Index (SI) (see Abouzeedan, 2001; Abouzeedan and Busler, 2002a). The new parameter is used to evaluate the performance of Small and Medium-size Enterprises (SMEs) utilizing firm survivability as an indicator. The SI is calculated using an equation known as Survival Index (SI) Value Equation or SIE. In this paper, we applied the SIV® model to run an analysis on a very young Swedish firm and up to our knowledge, for the first time. The firm is a small one, working within a business sector defined as "fish preparation industry". This particular enterprise had a bad performance through its short life. The purpose of this study is to truly determine if the SIV® model has the capacity to indicate the performance of the firm. The case study presented in this work showed the valuable analytical power of the new model since it succeeded in giving a clear indication of the worsening situation of the enterprise. During the SIV® analysis of this Swedish firm new concepts have been introduced which do increase the practicality and analytical capacity of the model.

    Place, publisher, year, edition, pages
    World Scientific Publishing Co., 2004
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71340 (URN)10.1142/S0218495804000154 (DOI)
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2017-12-08Bibliographically approved
    4. Innovation Balance Matrix: an application in the Arab countries
    Open this publication in new window or tab >>Innovation Balance Matrix: an application in the Arab countries
    2006 (English)In: World Review of Entrepreneurship, Management and Sustainable Development, ISSN 1746-0573, E-ISSN 1746-0581, Vol. 2, no 3, p. 270-280Article in journal (Refereed) Published
    Abstract [en]

    Economies have different levels of entrepreneurial activities depending on the availability of tangible as well as intangible resources. In their working paper, Abouzeedan and Busler (2004) established a new type of capital, adding up the components of the most important types of capital. These are the human capital, financial capital and the system capital. In that paper, the two researchers defined each of the components and explained what they meant with those terminologies. They called this new type of capital, innovation capital. The two researchers have argued that innovation capital can be used as an indicator for the degree of richness of the entrepreneurial environment in a region and thus the general character of the economy. They also introduced the Innovation Balance Matrix or IBAM as an analytical tool to classify economies based on their entrepreneurial conditions. In this extended work, they have used this analysis and tried to apply it to Arab countries using a general knowledge and deductive approach to the issue. They conclude the paper with some recommendations as how to enrich the innovation capital in that region.

    Place, publisher, year, edition, pages
    Inderscience Enterprises Limited, 2006
    Keywords
    Human capital; financial capital; system capital; innovation capital; innovation balance matrix; IBAM; Arab countries; Middle East; entrepreneurship.
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71341 (URN)10.1504/WREMSD.2006.009893 (DOI)
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2017-12-08Bibliographically approved
    5. Entrepreneurial policies and the innovation balance matrix: the case of the Arab countries
    Open this publication in new window or tab >>Entrepreneurial policies and the innovation balance matrix: the case of the Arab countries
    2007 (English)In: Science,Technology and Sustainability in the Middle East and North Africa: Section III: Science Technology and Innovation / [ed] Allam Ahmed, Inderscience Enterprises Limited , 2007, p. 158-175Chapter in book (Refereed)
    Abstract [en]

    The issue of the connection between economic progress and the entrepreneurial environment has been investigated by researchers using diverse approaches. One way to investigate the question is to use deductive analysis regarding the forms of capital contributing to the entrepreneurial environment of society. Adli Abouzeedan and Michael Busler were the first to introduce the concept of 'Innovation Capital'. The two researchers argued that Innovation Capital can be used as an indicator for the degree of richness of the entrepreneurial environment. In the same paper, the researchers also introduced the Innovation Balance Matrix (IBAM) as an analytical tool to classify economies based on their entrepreneurial conditions, applying it across the globe. In a later work, the two researchers tried to run a similar IBAM analysis focusing on the Arab world. The two writers found that the best solution to the lack of individual entrepreneurial economies in that region is through what they called the 'additive solution'. In this work, we take their argument deeper and look at the kind of policies that would achieve that solution.

    Place, publisher, year, edition, pages
    Inderscience Enterprises Limited, 2007
    Series
    Globalisation, Technology and Sustainable Development Book Series
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71342 (URN)0-907776-30-2 (ISBN)0-907776-32-9 (ISBN)
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2011-11-21Bibliographically approved
    6. Managing Innovation in a Globalised Economy: Defining the Open Capital
    Open this publication in new window or tab >>Managing Innovation in a Globalised Economy: Defining the Open Capital
    2009 (English)In: World Sustainable Development Outlook 2009. The Impact of the Global Financial Crisis on the Environment, Energy and Sustainable Development / [ed] Allam Ahmed, World Association for Sustainable Development , 2009, p. 287-294Chapter in book (Refereed)
    Abstract [en]

    Economies develop different levels of entrepreneurial capacity depending on the degree of availability of tangible as well as intangible resources. In an earlier work by Abouzeedan and Busler (2006), a new type of capital, that is, innovation capital, has been suggested to serve as an indicator for the degree of richness of the entrepreneurial environment in an economy. Innovation capital incorporates the concepts of human capital, financial capital and system capital. However, the issue of accessibility and openness in the innovation process also need to be reflected in the innovation capital concept. Innovation activities in the modern economies are growing to become more interconnected and open in their nature. In this paper, we defined and incorporated a new component within the innovation capital, namely open capital. We also reflected on how the four components of the innovation capital concept, including the open capital, are interconnected.

    Place, publisher, year, edition, pages
    World Association for Sustainable Development, 2009
    Keywords
    Open Capital, Human Capital, Financial Capital, System Capital, Innovation Capital, Open Innovation, Open Innovation Management
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71344 (URN)978-1-907106-05-7 (ISBN)
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2011-11-21Bibliographically approved
    7. Analysis of a Swedish High Technology SME Using the Survival Index Value (SIV) Model
    Open this publication in new window or tab >>Analysis of a Swedish High Technology SME Using the Survival Index Value (SIV) Model
    2011 (English)In: Paper Sessions, Workshops and Special Meetings: The 56th ICSB World Conference, Stockholm, Sweden, 15th and 18th of June, ICSB , 2011, p. 170-179Conference paper, Published paper (Refereed)
    Abstract [en]

    One of the major deficiencies in the existing Small and Medium-sized Enterprises’ (SMEs) performance evaluation models is the fact that they lack a clear coupling to the issue of innovation and its impact on performance. A possible candidate model which could achieve this is the Survival Index Value (SIV) model. The model has a parameter incorporated in its structure, the technology-intake. This parameter can be used as an indicator of the degree of innovativeness of the firm. Previous works using the model looked at general performance without specific focus on innovation activities of the firm and without relating that to aspects of survival and growth. In this paper the aim was to demonstrate the ability of the SIV model to indicate a positive overall performance due to the intensive investment of a selected firm in innovation activities.

    The enterprise analyzed, Autoadapt AB, is a Swedish high technology firm working in adapting cars and automobiles to handicapped people. Due to the nature of their activities the firm has a high level of innovation input to be able to solve the complex problems related to usage of cars by disabled people. Both the product development process and managing the activities around it requires a high level of innovativeness and ingenuity. As thus the firm presented a very interesting object to study. The study has a clear significance as there is a need to differentiate the performance of innovation-intensive enterprises from firms who are using less investment in innovation in their activities. This can be done by considering the investment in new technologies both as product development and/or as investing in absorption of external management, product or process innovation. Applying the SIV model to run this analysis can help to demonstrate the need to incorporate the technology intake as an essential component of SME’s performance model.

    The results indicated that the SIVmodel is able to predict correctly the performance of the object firm. By having mostly positive survival factor values, which are single data-points, during years of operation, and also having mostly positive survivability coefficient values, which are agglomerate data-points, the SIVmodel proved its abilities. Clearly, the model has a good potential to be developed and fine-tuned even more. The SIV model can be tested further to look at deviations in performance of firms among different sectors and relates that to the innovativeness of whole sectors.

    Place, publisher, year, edition, pages
    ICSB, 2011
    Keywords
    small and medium-sized enterprises, SMEs, performance evaluation models, SIV model
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-71345 (URN)978-0-9819028-3-8 (ISBN)0-9819028-3-9 (ISBN)
    Conference
    ICSB 2011 World Conference Date: June 15-18, 2011, Stockholm Waterfront Congress Center, Stockholm, Sweden
    Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2016-05-04Bibliographically approved
  • 204.
    Abouzeedan, Adli
    et al.
    Amana Commercial Consultants, Partille, Sweden.
    Busler, Michael
    Pennsylvania State University USA.
    Analysis of Swedish Fishery Company Using SIV® Model: A Case Study2004In: Journal of Enterprising Culture, ISSN 0218-4958, Vol. 12, no 4, p. 277-301Article in journal (Refereed)
    Abstract [en]

    In his original work of the Survival Index Value (SIV®) model, Dr. Adli Abouzeedan proposed a new parameter, which he named as the Survival Index (SI) (see Abouzeedan, 2001; Abouzeedan and Busler, 2002a). The new parameter is used to evaluate the performance of Small and Medium-size Enterprises (SMEs) utilizing firm survivability as an indicator. The SI is calculated using an equation known as Survival Index (SI) Value Equation or SIE. In this paper, we applied the SIV® model to run an analysis on a very young Swedish firm and up to our knowledge, for the first time. The firm is a small one, working within a business sector defined as "fish preparation industry". This particular enterprise had a bad performance through its short life. The purpose of this study is to truly determine if the SIV® model has the capacity to indicate the performance of the firm. The case study presented in this work showed the valuable analytical power of the new model since it succeeded in giving a clear indication of the worsening situation of the enterprise. During the SIV® analysis of this Swedish firm new concepts have been introduced which do increase the practicality and analytical capacity of the model.

  • 205.
    Abouzeedan, Adli
    et al.
    Amana Commercial Consultants, Partille, Sweden.
    Busler, Michael
    Pennsylvania State University, Great Valley Graduate Center, Malvern, PA 19355.
    ASPEM as the New Topographic Analysis Tool for Small and Medium-Sized Enterprises (SMEs) Performance Models Utilization2005In: International Journal of Entrepreneurship, ISSN 1099-9264, E-ISSN 1939-4675, Vol. 3, no 1, p. 53-70Article in journal (Refereed)
    Abstract [en]

    Quantifying and measuring small firm performance is vital in our understanding of how internationalization influences firm performance. That is also important when attempting to grasp the mechanisms of the internationalization processes. There are few methods used for the evaluation of performance of Small and Medium-sized Enterprise (SMEs). These methods can be either macro or micro economic in nature. Hazard Modeling, Stochastic Models, and Learning Models are examples of macro economic models while Z-Scores, ZETA-Scores, Neural Networks, and the SIV® model are examples of micro models. Choosing the most suitable performance model is an essential step in order to maximize our knowledge in relation to firm performance. Utilizing SMEs performance measures without thinking about the category of model, will bias the outcome of the majority of SMEs studies. However, using firm performance diverse models in an efficient manner requires strategic thinking. In this paper, we are re-introducing a tool that can accommodate that aspect. Abouzeedan (2002) designated the new tool: the Arena of SMEs Performance Models or an ASPEM diagram. The horizontal axis in the diagram indicates the Information Intensity Requirements of the model. The vertical axis indicates the Coverage Intensity of the model varying from an individual firm up to a whole group of firms. By allocating each of the SMEs performance models, at the suitable region of the ASPEM Diagram, researchers can better build a sound strategy for the application of these methods.

  • 206.
    Abouzeedan, Adli
    et al.
    Amana Commercial Consultants, Partille, Sweden.
    Busler, Michael
    Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USA.
    Entrepreneurial policies and the innovation balance matrix: the case of the Arab countries2007In: Science,Technology and Sustainability in the Middle East and North Africa: Section III: Science Technology and Innovation / [ed] Allam Ahmed, Inderscience Enterprises Limited , 2007, p. 158-175Chapter in book (Refereed)
    Abstract [en]

    The issue of the connection between economic progress and the entrepreneurial environment has been investigated by researchers using diverse approaches. One way to investigate the question is to use deductive analysis regarding the forms of capital contributing to the entrepreneurial environment of society. Adli Abouzeedan and Michael Busler were the first to introduce the concept of 'Innovation Capital'. The two researchers argued that Innovation Capital can be used as an indicator for the degree of richness of the entrepreneurial environment. In the same paper, the researchers also introduced the Innovation Balance Matrix (IBAM) as an analytical tool to classify economies based on their entrepreneurial conditions, applying it across the globe. In a later work, the two researchers tried to run a similar IBAM analysis focusing on the Arab world. The two writers found that the best solution to the lack of individual entrepreneurial economies in that region is through what they called the 'additive solution'. In this work, we take their argument deeper and look at the kind of policies that would achieve that solution.

  • 207.
    Abouzeedan, Adli
    et al.
    Amana Commercial Consultants, Partille, Sweden.
    Busler, Michael
    Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USA.
    Innovation Balance Matrix: an application in the Arab countries2006In: World Review of Entrepreneurship, Management and Sustainable Development, ISSN 1746-0573, E-ISSN 1746-0581, Vol. 2, no 3, p. 270-280Article in journal (Refereed)
    Abstract [en]

    Economies have different levels of entrepreneurial activities depending on the availability of tangible as well as intangible resources. In their working paper, Abouzeedan and Busler (2004) established a new type of capital, adding up the components of the most important types of capital. These are the human capital, financial capital and the system capital. In that paper, the two researchers defined each of the components and explained what they meant with those terminologies. They called this new type of capital, innovation capital. The two researchers have argued that innovation capital can be used as an indicator for the degree of richness of the entrepreneurial environment in a region and thus the general character of the economy. They also introduced the Innovation Balance Matrix or IBAM as an analytical tool to classify economies based on their entrepreneurial conditions. In this extended work, they have used this analysis and tried to apply it to Arab countries using a general knowledge and deductive approach to the issue. They conclude the paper with some recommendations as how to enrich the innovation capital in that region.

  • 208.
    Abouzeedan, Adli
    et al.
    Amana Commercial Consultants, Partille, Sweden.
    Busler, Michael
    Pennsylvania State University, Great Valley Graduate Center, Malvern, PA 19355, USA.
    Typology Analysis of Performance Models of Small and Medium-Size Enterprises (SMEs)2004In: International Journal of Entrepreneurship, ISSN 1099-9264, E-ISSN 1939-4675, Vol. 2, no 1-2, p. 155-177Article in journal (Refereed)
    Abstract [en]

    A number of firm performance models are available. Reviewing these models and pointing out their individual strengths and weaknesses, would help both academic researchers and professional users to understand and appreciate how and when to use these various models. The theoretical models for Small and Medium-size Enterprise (SME) performance can be divided into two categories: firm dynamics theories and performance prediction models. In the first part of this paper we review, in a condensed manner, the most relevant firm dynamic theories, i.e. SME's performance models. These include: Stochastic Theories, Learning Model Theories and Hazard Modeling Theories. In the second part of this paper, we examine the performance prediction models of SMEs, which include Z-Scores, ZETA-Scores, Neural Networks (NN) and the SIV® models, among others. The strengths and weaknesses of each of these models are exposed and discussed.

  • 209.
    Abouzeedan, Adli
    et al.
    University of Gothenburg, Sweden.
    Busler, Michael
    The Richard Stockton College of New Jersey, USA.
    Hedner, Thomas
    University of Gothenburg, Sweden.
    Managing Innovation in a Globalised Economy: Defining the Open Capital2009In: World Sustainable Development Outlook 2009. The Impact of the Global Financial Crisis on the Environment, Energy and Sustainable Development / [ed] Allam Ahmed, World Association for Sustainable Development , 2009, p. 287-294Chapter in book (Refereed)
    Abstract [en]

    Economies develop different levels of entrepreneurial capacity depending on the degree of availability of tangible as well as intangible resources. In an earlier work by Abouzeedan and Busler (2006), a new type of capital, that is, innovation capital, has been suggested to serve as an indicator for the degree of richness of the entrepreneurial environment in an economy. Innovation capital incorporates the concepts of human capital, financial capital and system capital. However, the issue of accessibility and openness in the innovation process also need to be reflected in the innovation capital concept. Innovation activities in the modern economies are growing to become more interconnected and open in their nature. In this paper, we defined and incorporated a new component within the innovation capital, namely open capital. We also reflected on how the four components of the innovation capital concept, including the open capital, are interconnected.

  • 210.
    Abouzeedan, Adli
    et al.
    Innovation and Entrepreneurship, Department of Medicine Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden.
    Hedner, Thomas
    Innovation and Entrepreneurship, Department of Medicine Sahlgrenska Academy, University of.
    Klofsten, Magnus
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering. Linköping University, HELIX Competence Centre.
    Innovation and entrepreneurship – new themes for new times2010In: Annals of Innovation & Entrepreneurship, ISSN 2000-7396, E-ISSN 2000-7396, ISSN ISSN 2000-7396, Vol. 1, no 1, p. 1-3Article in journal (Other academic)
    Abstract [en]

    Throughout history, innovators and entrepreneurs have had a tremendous impact on development, exploration, trade, education, science, and integration. During the 20th century, innovation and entrepre-neurship have been regarded as key drivers in technological progress and productivity development worldwide. New radical innovations from new fields of knowledge such as information and communication technologies and biotechnology have emerged to influence everyday life for most people. Realizing this, policy makers as well as individuals argue that innovative and entrepreneurial change processes need to be further implemented on the micro as well as macro levels in society (Abouzeedan, Busler, & Hedner, 2009; Busenitz, Gomez, & Spencer, 2000). The study of innovation is therefore likely to be an increasingly important topic in, for example, economics, business, entrepreneurship, tech-nology, engineering, medicine, environmental biology, sociology, design, and reregional development (cf. Etzkowitz & Klofsten, 2005).

  • 211.
    Abouzeedan, Adli
    et al.
    Sahlgrenska Academy, University of Gothenburg, Sweden.
    Klofsten, Magnus
    Linköping University, Department of Management and Engineering, Project management, Innovations and Entrepreneurship . Linköping University, The Institute of Technology.
    Hedner, Thomas
    Sahlgrenska Academy, University of Gothenburg, Sweden.
    Analysis of a Swedish High Technology SME Using the Survival Index Value (SIV) Model2011In: Paper Sessions, Workshops and Special Meetings: The 56th ICSB World Conference, Stockholm, Sweden, 15th and 18th of June, ICSB , 2011, p. 170-179Conference paper (Refereed)
    Abstract [en]

    One of the major deficiencies in the existing Small and Medium-sized Enterprises’ (SMEs) performance evaluation models is the fact that they lack a clear coupling to the issue of innovation and its impact on performance. A possible candidate model which could achieve this is the Survival Index Value (SIV) model. The model has a parameter incorporated in its structure, the technology-intake. This parameter can be used as an indicator of the degree of innovativeness of the firm. Previous works using the model looked at general performance without specific focus on innovation activities of the firm and without relating that to aspects of survival and growth. In this paper the aim was to demonstrate the ability of the SIV model to indicate a positive overall performance due to the intensive investment of a selected firm in innovation activities.

    The enterprise analyzed, Autoadapt AB, is a Swedish high technology firm working in adapting cars and automobiles to handicapped people. Due to the nature of their activities the firm has a high level of innovation input to be able to solve the complex problems related to usage of cars by disabled people. Both the product development process and managing the activities around it requires a high level of innovativeness and ingenuity. As thus the firm presented a very interesting object to study. The study has a clear significance as there is a need to differentiate the performance of innovation-intensive enterprises from firms who are using less investment in innovation in their activities. This can be done by considering the investment in new technologies both as product development and/or as investing in absorption of external management, product or process innovation. Applying the SIV model to run this analysis can help to demonstrate the need to incorporate the technology intake as an essential component of SME’s performance model.

    The results indicated that the SIVmodel is able to predict correctly the performance of the object firm. By having mostly positive survival factor values, which are single data-points, during years of operation, and also having mostly positive survivability coefficient values, which are agglomerate data-points, the SIVmodel proved its abilities. Clearly, the model has a good potential to be developed and fine-tuned even more. The SIV model can be tested further to look at deviations in performance of firms among different sectors and relates that to the innovativeness of whole sectors.

  • 212.
    Abouzeedan, Adli
    et al.
    University of Gothenburg.
    Klofsten, Magnus
    Linköping University, Department of Management and Engineering, Project management, Innovations and Entrepreneurship . Linköping University, The Institute of Technology.
    Hedner, Thomas
    University of Gothenburg.
    Implementing the SIV Model on an Intensively Innovation-Oriented Firm: The Case of Autoadapt AB2012In: World Journal of Entrepreneurship, Management and Sustainable Development, ISSN 2042-5961, Vol. 8, no 2/3, p. 122-145Article in journal (Refereed)
    Abstract [en]

    Small to medium-sized enterprise (SME) evaluation models lack a clear coupling to innovation and its impact on firm performance. A model which can achieve this is the Survival Index Value (SIV) model. The purpose of this paper is to demonstrate the ability of the SIV model to indicate and predict the performance of a company. The firm, Autoadapt AB, is an innovation-oriented enterprise, adapting personal cars to be driven by handicapped people. The authors knew in advance about the good performance of the firm and its high efficiency in conducting its operations and expected the SIV model to reflect correctly on Autoadapt's performance. Because the handicap degree of each of the individuals who benefit from the firm activities differs from one person to another, product solutions have to be individually designed. Therefore the firm has had to pursue a high level of innovativeness and it had to abide with this policy right from the start. The product development processes in the firm needed to adapt to such strategies.

    To be able to demonstrate the ability of the SIV model to indicate a positive performance due to the intensive innovation activities of Autoadapt AB, a case study approach was used. Case studies are very suited for in-depth analysis of an object under a longer period of time. It is a widely-used research method in firm performance studies.

    The results of the SIV analysis indicated that the model is able to project correctly the performance of the object firm. At all the four levels of analysis, i.e. SI values, the SPI slope, the survival factors, and the survivability coefficients, the SIV analysis performance indicated a stable positive development of the firm through the life time of the enterprise.

    Measuring performance of SMEs is an important issue. There are couple of models stemming from the traditional accountancy disciplines in use; however these models suffer from clear disadvantages. Recently a new model, the SIV model, was introduced and has shown the ability of being a better candidate for performance analysis. The paper demonstrates the ability of the SIV model to judge correctly the performance of an innovative firm.

  • 213.
    Aboyans, Victor
    et al.
    Dupuytren University Hospital.
    Criqui, Michael
    University of California, USA.
    Abraham, Pierre
    University Hospital of Angers, France.
    Allison, Matthew
    University of California, USA.
    Creager, Mark
    Brigham and Women’s Hospital, USA.
    Diehm, Curt
    Karlsbad Clinic/University of Heidelberg, Germany.
    Fowkes, Gerry
    University of Edinburgh, UK.
    Hiatt, William
    University of Colorado, USA.
    Jönsson, Björn
    Linköping University, Department of Medical and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
    Lacroix, Philippe
    Limoges University, France.
    Marin, Benoit
    Limoges Teaching Hospital, France.
    McDermott, Mary
    Northwestern University,USA.
    Norgren, Lars
    University Hospital, Örebro, Sweden.
    Pande, Reena
    Brigham and Women’s Hospital, USA.
    Preux, Pierre-Marie
    University of Limoges, France.
    Stoffers, H.E.
    Maastricht University, Netherlands.
    Treat-Jacobsson, Diane
    University of Minnesota, USA.
    Measurement and interpretation of the ankle-brachial index: a scientific statement from the Ammerican Heart Association2012In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539Article in journal (Refereed)
  • 214.
    Abraham-Nordling, Mirna
    et al.
    Karolinska institutet.
    Persson, Bengt
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, The Institute of Technology.
    Nordling, Erik
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, The Institute of Technology.
    Model of the complex of Parathyroid hormone-2receptor and Tuberoinfundibular peptide of39 residues2010In: BMC Reseach Notes, ISSN 1756-0500, Vol. 3, no 270Article in journal (Refereed)
    Abstract [en]

    Background

    We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex. The two related peptides parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) are compared with the complex to examine their interactions.

    Findings

    In the model, the hydrophobic N-terminus of TIP39 is buried in a hydrophobic part of the central cavity between helices 3 and 7. Comparison of the peptide sequences indicates that the main discriminator between the agonistic peptides TIP39 and PTH and the inactive PTHrP is a tryptophan-phenylalanine replacement. The model indicates that the smaller phenylalanine in PTHrP does not completely occupy the binding site of the larger tryptophan residue in the other peptides. As only TIP39 causes internalisation of the receptor and the primary difference being an aspartic acid in position 7 of TIP39 that interacts with histidine 396 in the receptor, versus isoleucine/histidine residues in the related hormones, this might be a trigger interaction for the events that cause internalisation.

    Conclusions

    A model is constructed for the complex and a trigger interaction for full agonistic activation between aspartic acid 7 of TIP39 and histidine 396 in the receptor is proposed.

  • 215.
    Abrahams, M
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology.
    Eriksson, H
    Björnström, Karin
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Eintrei, Christina
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Effects of propofol on extracellular acidification rates in primary cortical cell cultures: application of silicon microphysiometry to anaesthesia.1999In: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 83, p. 567-569Article in journal (Refereed)
  • 216.
    Abrahams, M
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Sjöberg, Folke
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
    Oscarsson, Anna
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Sundqvist, Tommy
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    The effects of human burn injury on urinary nitrate excretion. 1999In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 25, p. 29-33Article in journal (Refereed)
  • 217.
    Abrahamsson, Annelie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Capodanno, Alessandra
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Rzepecka, Anna
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
    Dabrosin, Charlotta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Downregulation of tumor suppressive microRNAs in vivo in dense breast tissue of postmenopausal women2017In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 54, p. 92134-92142Article in journal (Refereed)
    Abstract [en]

    Women with dense breast tissue on mammography are at higher risk of developing breast cancer but the underlying mechanisms are not well understood. De-regulation of microRNAs (miRNAs) has been associated with the onset of breast cancer. miRNAs in the extracellular space participate in the regulation of the local tissue microenvironment. Here, we recruited 39 healthy postmenopausal women attending their mammography-screen that were assessed having extreme dense or entirely fatty breasts (nondense). Microdialysis was performed in breast tissue and a reference catheter was inserted in abdominal subcutaneous fat for local sampling of extracellular compounds. Three miRNAs, associated with tumor suppression, miR-193b, miR-365a, and miR-452 were significantly down-regulated in dense breast tissue compared with nondense breast tissue. In addition, miR-452 exhibited significant negative correlations with several pro-inflammatory cytokines in vivo, which was confirmed in vitro by overexpression of miR-452 in breast cancer cells. No differences were found of miR-21, -29a, -30c, 146a, -148a, -203, or -451 in breast tissue and no miRs were different in plasma. Extracellular miRNAs may be among factors that should be included in studies of novel prevention strategies for breast cancer.

  • 218.
    Abrahamsson, Annelie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Dabrosin, Charlotta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo2015In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 6, no 26, p. 22959-22969Article in journal (Refereed)
    Abstract [en]

    Extracellular circulating microRNAs (miRNAs) have been suggested to be biomarkers for disease monitoring but data are inconsistent, one reason being that blood miRNA is of heterogeneous origin. Here, we sampled extracellular microRNAs locally in situ using microdialysis. Three different cohorts of women were included; postmenopausal women with ongoing breast cancer investigated within the cancer and in normal adjacent breast tissue, postmenopausal women investigated in their normal healthy breast and subcutaneous fat before and after six weeks of tamoxifen therapy, premenopausal women during the menstrual cycle. Samples were initially screened using TaqMan array cards with subsequently absolute quantification. 124 miRNA were expressed in microdialysates. After absolute quantifications extracellular miRNA-21 was found to be significantly increased in breast cancer. In addition, the levels were significantly higher in pre-menopausal breast tissue compared with postmenopausal. In breast tissue of pre-menopausal women miRNA-21 exhibited a cyclic variation during the menstrual cycle and in postmenopausal women six weeks of tamoxifen treatment decreased miRNA-21 suggesting that this miRNA may be important for breast carcinogenesis. None of these changes were found in plasma or microdialysates from subcutaneous fat. Our data revealed tissue specific changes of extracellular circulating miRNAs that would be otherwise unraveled using blood samples.

  • 219.
    Abrahamsson, Annelie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    Morad, Vivian
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Saarinen, Niina M
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    Dabrosin, Charlotta
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology UHL.
    Estradiol, Tamoxifen, and Flaxseed Alter IL-1 beta and IL-1Ra Levels in Normal Human Breast Tissue in Vivo2012In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 97, no 11, p. E2044-E2054Article in journal (Refereed)
    Abstract [en]

    Introduction: Sex steroid exposure increases the risk of breast cancer by unclear mechanisms. Diet modifications may be one breast cancer prevention strategy. The proinflammatory cytokine family of IL-1 is implicated in cancer progression. IL-1Ra is an endogenous inhibitor of the proinflammatory IL-1 alpha and IL-1 beta. less thanbrgreater than less thanbrgreater thanObjective: The objective of this study was to elucidate whether estrogen, tamoxifen, and/or diet modification altered IL-1 levels in normal human breast tissue. less thanbrgreater than less thanbrgreater thanDesign and Methods: Microdialysis was performed in healthy women under various hormone exposures, tamoxifen therapy, and diet modifications and in breast cancers of women before surgery. Breast tissue biopsies from reduction mammoplasties were cultured. less thanbrgreater than less thanbrgreater thanResults: We show a significant positive correlation between estradiol and in vivo levels of IL-1 beta in breast tissue and abdominal sc fat, whereas IL-1Ra exhibited a significant negative correlation with estradiol in breast tissue. Tamoxifen or a dietary addition of 25 g flaxseed per day resulted in significantly increased levels of IL-1Ra in the breast. These results were confirmed in ex vivo culture of breast biopsies. Immunohistochemistry of the biopsies did not reveal any changes in cellular content of the IL-1s, suggesting that mainly the secreted levels were affected. In breast cancer patients, intratumoral levels of IL-1 beta were significantly higher compared with normal adjacent breast tissue. less thanbrgreater than less thanbrgreater thanConclusion: IL-1 may be under the control of estrogen in vivo and may be attenuated by antiestrogen therapy and diet modifications. The increased IL-1 beta in breast cancers of women strongly suggests IL-1 as a potential therapeutic target in breast cancer treatment and prevention.

  • 220.
    Abrahamsson, Annelie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Rzepecka, Anna
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
    Dabrosin, Charlotta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Equal Pro-inflammatory Profiles of CCLs, CXCLs, and Matrix Metalloproteinases in the Extracellular Microenvironment In Vivo in Human Dense Breast Tissue and Breast Cancer2018In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 8, article id 1994Article in journal (Refereed)
    Abstract [en]

    The inflammatory microenvironment affects breast cancer progression. Proteins that govern the inflammatory response are secreted into the extracellular space, but this compartment still needs to be characterized in human breast tissues in vivo. Dense breast tissue is a major risk factor for breast cancer by yet unknown mechanisms and no non-toxic prevention for these patients exists. Here, we used the minimal invasive technique of microdialysis for sampling of extracellular proteins in live tissues in situ in breast cancers of women before surgery and in healthy women having dense or non-dense breast tissue on mammography. Proteins were profiled using a proximity extension assay. Out of the 32 proteins assessed, 26 exhibited similar profiles in breast cancers and dense breast tissues; CCL-4, -7, -8, -11, -15, -16, -22, -23, and -25, CXCL-5, -8, -9, -16 as well as sIL-6R, IL-18, vascular endothelial growth factor, TGF-a, fibroblast growth factor 19, matrix metalloproteinase (MMP)-1, -2, -3, and urokinase-type plasminogen activator were all increased, whereas CCL-3, CX3CL1, hepatocyte growth factor, and MMP-9 were unaltered in the two tissues. CCL-19 and -24, CXCL-1 and -10, and IL-6 were increased in dense breast tissue only, whereas IL-18BP was increased in breast cancer only. Our results provide novel insights in the inflammatory microenvironment in human breast cancer in situ and define potential novel therapeutic targets. Additionally, we show previously unrecognized similarities of the pro-inflammatory microenvironment in dense breast tissue and breast cancer in vivo suggesting that anti-inflammatory breast cancer prevention trials for women with dense breast tissue may be feasible.

  • 221.
    Abrahamsson, Annelie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Rzepecka, Anna
    Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Dabrosin, Charlotta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Increased nutrient availability in dense breast tissue of postmenopausal women in vivo2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 42733Article in journal (Refereed)
    Abstract [en]

    Metabolic reprogramming is a hallmark of cancer. Nutrient availability in the tissue microenvironment determines cellular events and may play a role in breast carcinogenesis. High mammographic density is an independent risk factor for breast cancer. Whether nutrient availability differs in normal breast tissues with various densities is unknown. Therefore we investigated whether breast tissues with various densities exhibited differences in nutrient availability. Healthy postmenopausal women from the regular mammographic screening program who had either predominantly fatty breast tissue (nondense), n = 18, or extremely dense breast tissue (dense), n = 20, were included. Microdialysis was performed for the in vivo sampling of amino acids (AAs), analyzed by ultra-high performance liquid chromatography with tandem mass spectroscopy, glucose, lactate and vascular endothelial growth factor (VEGF) in breast tissues and, as a control, in abdominal subcutaneous (s.c.) fat. We found that dense breast tissue exhibited significantly increased levels of 20 proteinogenic AAs and that 18 of these AAs correlated significantly with VEGF. No differences were found in the s.c. fat, except for one AA, suggesting tissue-specific alterations in the breast. Glucose and lactate were unaltered. Our findings provide novel insights into the biology of dense breast tissue that may be explored for breast cancer prevention strategies.

  • 222.
    Abrahamsson, Annelie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Rzepecka, Anna
    Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
    Romu, Thobias
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Borga, Magnus
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Dahlqvist Leinhard, Olof
    Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Lundberg, Peter
    Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Kihlberg, Johan
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
    Dabrosin, Charlotta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo2016In: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 5, no 10, article id e1229723Article in journal (Refereed)
    Abstract [en]

    Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment.Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes. On the MRI, lean tissue fraction (LTF) was calculated for a continuous measurement of breast density. LTF confirmed the selection from the mammograms and gave a continuous measurement of breast density. Microdialysis revealed significantly increased extracellular in vivo levels of IL-6, IL-8, vascular endothelial growth factor, and CCL5 in dense breast tissue as compared with nondense breasts. Moreover, the ratio IL-1Ra/IL-1 was decreased in dense breasts. No differences were found in levels of IL-1, IL-1Ra, CCL2, leptin, adiponectin, or leptin:adiponectin ratio between the two breast tissue types. Significant positive correlations between LTF and the pro-inflammatory cytokines as well as between the cytokines were detected. Stainings of the core biopsies exhibited increased levels of immune cells in dense breast tissue.Our data show that dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment and, if confirmed in a larger cohort, suggests novel targets for prevention therapies for women with dense breast tissue.

  • 223.
    Abrahamsson, Kenneth
    et al.
    Department of Business Administration, Technology and Social Sciences, Human Work Science, Luleå univeristet.
    Abrahamsson, LenaDepartment of Business Administration, Technology and Social Sciences, Human Work Science, Luleå univeristet.Björkman, TorstenDepartment of Business Administration, Technology and Social Sciences, Human Work Science, Luleå univeristet.Ellström, Per-ErikLinköping University, HELIX Vinn Excellence Centre. Linköping University, Department of Behavioural Sciences and Learning, Work and Working Life. Linköping University, Department of Behavioural Sciences and Learning, Education and Sociology. Linköping University, Faculty of Arts and Sciences.Johansson, JanDepartment of Business Administration, Technology and Social Sciences, Human Work Science, Luleå univeristet.
    Utbildning, kompetens och arbete2002Collection (editor) (Other academic)
    Abstract [sv]

    Syftet med denna bok är att ge en översiktsbild av forskning om samspelet mellan utbildning, yrkesverksamhet och lärande. Avsikten är också att överbrygga klyftan mellan en i huvudsak utbildningsinriktad forskning och en forskning med tonvikt på lärande, utveckling och förändring. Fokus är kompetensförsörjningen till och inom arbetslivet. Uppmärksamhet ägnas även överutbildning och underlärande, dvs. den klassiska frågan om matchning mellan utbud och efterfrågan. Innehållet belyser även yrkesbegreppet och hur kvalifikationskraven ändras eller är stabila över tid i olika verksamheter samt villkoren för lärande på arbetsplatsen.

    Förutom en översikt av aktuell svensk forskning syftar boken till att skapa underlag för policyutveckling och konkreta insatser när det gäller villkoren för kompetensförsörjning och lärande i arbetslivet. Boken riktar sig till utbildningar i högskolan i allmänhet och lärarutbildningar i synnerhet med syfte att skapa ökad insikt om hur kunskap utvecklas och nyttiggörs i utbildning och arbetsliv. En annan målgrupp är politiker, utbildningsplanerare och företrädare för arbetsmarknadspolitik och arbetsmarknadens parter med intresse för hur utbildning, arbetsmarknad och välfärd utvecklas i Sverige.

  • 224. Abrahamsson, Lena
    et al.
    Bengtsson, Lars
    Gremyr, Ida
    Kowalkowski, Christian
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Lindahl, Marcus
    Nilsson, Anders
    Rehn, Alf
    Segerstedt, Anders
    Säfsten, Kristina
    Öhman, Peter
    Industriell ekonomi och organisering2016Book (Refereed)
  • 225.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Affärsmodeller för citylogistik & samordnad varudistribution: Handbok för kommuner och privata aktörer2017Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Den här handboken är resultatet av forskningsprojektet ”Affärsmodeller för citylogistik” som har finansierats av Vinnova och genomförts av forskare på Linköpings Universitet vid avdelningen Logistik- & Kvalitetsutveckling under perioden 2015 – 2017. Projektet är en direkt uppföljning av Färdplan Citylogistik – Godstransporter i urbana miljöer som visade att citylogistik och samordnad varudistribution behövs för att kunna driva utvecklingen mot mer hållbara och attraktiva städer med emissionsfria godstransporter. Den här boken presenterar en modell som syftar till att hjälpa kommuner och företag att komma igång med citylogistik och samordnad varudistribution – En affärsmodell som också fungerar som ett beslutsunderlag. Projektet grundar sig också i Forsknings- och innovationsagenda för framtidens logistik, där citylogistik lyfts fram som ett av de viktigaste utvecklingsområdena inom logistikområdet i framtiden.

  • 226.
    Abrahamsson, Mats
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Dagens Managementverktyg är alldeles för trubbigt.2004In: TH : Transport & Hantering, ISSN 0346-2773, Vol. 5, p. 20-21Article in journal (Other (popular science, discussion, etc.))
  • 227.
    Abrahamsson, Mats
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Det är skillnad på elitserien och lägre divisioner2004In: TH : Transport & Hantering, ISSN 0346-2773, Vol. 4Article in journal (Other (popular science, discussion, etc.))
  • 228.
    Abrahamsson, Mats
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Logistics in the Strategy of the Firm2007In: NOFOMA,2006, 2007, p. 15-20Conference paper (Refereed)
  • 229.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Logistik för ökad svensk konkurrenskraft: Forsknings- och innovationsagenda för framtidens logistik2013Report (Other academic)
    Abstract [sv]

    Framtidens logistik står inför mycket stora utmaningar som har direkt bäring på svenska företags och organisationers förmåga till tillväxt, hållbarhet och konkurrenskraft. 

    Det står utom all tvivel att logistikens betydelse kommer att öka ännu mer i framtiden. Vinnare på de globala, rörliga marknaderna kommer ett vara de flödeseffektiva företagen, som har förmåga att hantera förändringarna på marknaden med en effektiv logistik som grund. För att lyckas behövs ett Logistiklyft för Sverige, med ett medvetet fokus på att utveckla de dynamiska förmågorna i företag och organisationer. Detta gäller i de allra flesta branscher och typ av företag.

    Den här innovations- och forskningsagendan utgår från den svenska traditionen och internationellt sett unika kunskapen och förmågan att med en systemsyn som grund designa, utveckla och styra komplexa system där flera olika kompetenser samverkar. Logistikens systemkunskap handlar om att lära sig att utforma och styra omfattande och allt mer komplexa försörjningskedjor (supply chains) från råvara till slutkund i syfte att öka svenska företags internationella konkurrenskraft och förmåga att växa på ett miljömässigt och ekonomiskt hållbart sätt

    Agendan adresserar behovet av kompetens och kunskap för mer innovativ logistikutveckling som följer:

    • Utveckling av kunskap om nya och mer innovativa logistiksystem och modeller för industri & handel 
    • Tjänsteutveckling för transport/logistik och IT-företag som stöd för mer innovativa logistiksystem, men också att ta till vara och stimulera den omfattande tjänsteutveckling som finns i förnyelsen av svenskt näringsliv, t ex mot högre grad av e-handel. 
    • Tillämpning av befintliga logistikkunskaper för områden och sektorer i behov av ett logistiklyft och ökad flödeseffektivitet, t.ex. logistik för små- och medelstora företag (SME) med fokus på HUR (genomförandeprocesser) istället för VAD (utformning av koncept och modeller). 
    • Utveckling av kunskaper om hur logistiksystem kan bidra till en hållbar utveckling, såväl miljömässigt som socialt.
    • Utveckling av kunskap om och tillämpning av logistiklösningar med primär samhällsnytta, t ex sjukvårdslogistik och citylogistik samt effektiv och hållbar försörjning av livsmedel, energi etc.

    Den här forsknigs- och innovationsagendan är utvecklad i samarbete mellan Linköpings Universitet, Lunds Tekniska Högskola, Chalmers Tekniska Högskola och en lång rad företag där Axis, SKF, Volvo och Nobel Biocare har funnits med i projektets styrgrupp. 

    Agendan finns endast som PDF. Kontakta Mats Abrahamsson, Linköpings Universitet. mats.abrahamsson@liu.se

  • 230.
    Abrahamsson, Mats
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Nya tider kräver nya managementverktyg2003In: Management magazine, ISSN 1651-8055, Vol. 2Article in journal (Other academic)
    Abstract [sv]

       

  • 231.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    The Role of Logistics in Corporate Strategy2010In: Dimensionen der Logistik / [ed] in Schönberger, R., & Elbert, R., Heidelberg: Gabler Research , 2010, p. 533-552Chapter in book (Other academic)
    Abstract [de]

    Funktionen, Institutionen und Handlungsebenen beschreiben die drei Dimensionen des von Professor Dr. Dr. h.c. Hans-Christian Pfohl geschaffenen Logistikwürfels. Anlässlich seiner Emeritierung beleuchten Wissenschaftler und Praktiker in 75 Fachbeiträgen die Logistik mit all ihren Facetten und aktuellen Entwicklungen und geben Anregungen für die zukünftige Forschung und Praxis.

  • 232.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    The Role of Logistics in Corporate Strategy2008In: Northern lights in logistics & supply chain management / [ed] Stentoft, Halldorsson, Jahre, Spens, Copenhagen: Copenhagen Business School Press, 2008, 1, p. 49-66Chapter in book (Refereed)
    Abstract [en]

    "Northern Lights in Logistics & Supply Chain Management" portrays the past, present and future research of the subject in the Nordic countries. The NOFOMA conference - a network of Nordic researchers within the field of Logistics and Supply Chain Management - has been a focal point in the contribution to the continuous improvement and further development of Nordic research. The network has also opened up for interaction with fellow researchers from other countries. There are sixteen chapters in the book that in its own way colours the Nordic rainbow of research within Logistics and Supply Chain Management. The chapters are structured in four themes: 1) Origins and strategic aspects; 2) Research approaches in the Nordic countries; 3) Advancement of distribution strategies and; 4) Emerging application areas of logistics and SCM. The chapters provide an understanding and, perhaps more importantly, consciousness for scholars that are part of this research environment: Where are we now, what have we been influenced by, and in what area are we able to provide positive impact? The aim of the book is also to contribute to increased visibility to fellow international scholars within Logistics and Supply Chain Management.

  • 233.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Aldin, Niklas
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Stahre, Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Logistics Platforms for Improved Dynamic Effectiveness2003In: International Journal of Logistics Management, ISSN 0957-4093, E-ISSN 1758-6550, Vol. 3Article in journal (Refereed)
  • 234.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Aronsson, Håkan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    A model for measuring logistics structures2003In: ESTIEM magazine, ISSN 0874-5242, Vol. 25, no 2/2003Article in journal (Other academic)
    Abstract [en]

      

  • 235.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Aronsson, Håkan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Ett avancerat laboratorium för visualisering av logistiksystem2004In: TH : Transport & Hantering, ISSN 0346-2773, Vol. 3, p. 18-19Article in journal (Other (popular science, discussion, etc.))
  • 236.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Aronsson, Håkan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Measuring Logistics Structure1999In: International Journal of Logistics Management, ISSN 0957-4093, E-ISSN 1758-6550, Vol. 2, no 3, p. 263-284Article in journal (Refereed)
  • 237.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Aronsson, Håkan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Lindskog, Magnus
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Beyond the Beer-Game: An Arena for Visualising Complex Logistics Systems.2004In: Annual NOFOMA Conference for Nordic Researchers in Logistics: Challenging Boundaries with Logistics.,2004, Linköping: Linköpings universitet , 2004Conference paper (Refereed)
  • 238.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Engineering, Logistics .
    Brege, Staffan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics .
    Dynamic effectiveness: Improved industrial distribution from interaction between marketing and logistics strategies2005In: Journal of Distribution Channels, ISSN 1046-669X, E-ISSN 1540-7039, Vol. 12, no 2, p. 83-112Article in journal (Refereed)
    Abstract [en]

    Based on different observations, in theory as well as in practice, we have identified strategies and operations following two different tracks, striving in different directions, despite it being well known they should go hand in hand. For companies challenged by a more and more dynamic business environment with heavier market segmentation, additional marketing channels, increasing globalisation on supplier and customer side, and high pressure on profit margins, the result from this is competitive weakness. The purpose of this article is to switch focus from operational effectiveness and strategic positioning as static success concepts on how to improve industrial distribution, to dynamic challenges of how to continuously manage the interaction between marketing strategies and operations (e.g., logistics) under the influence of a dynamic business environment. From theories in market strategies, logistics, flexibility, and marketing channels together with empirical experience from a best practice case study, we are introducing a model for dynamic effectiveness, describing the different characteristics of a company and what to focus on in order to become more dynamic. In order to constantly move to new market positions, and at the same time, restructure logistics and improve operational effectiveness, we have identified the dynamic capabilities of an organisation to be the key to success in industrial distribution. We define dynamic effectiveness as "how fast-and-well a company can go from one strategic positioning and productivity frontier to another." It tells that a frequent interaction between new strategic moves and actions for higher operational effectiveness is required to be in pace with the dynamic and changing business environment and to stay ahead of competition. As a part, of this, best, practice logistics performance makes it possible not only to be more agile to new strategic moves, but also to drive strategic development from a high operational level. This is achieved by designing logistics to be a resource base to support and be an enabler for new strategic moves on the market. © 2004 by The Haworth Press, Inc. All rights reserved.

  • 239.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Brege, Staffan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Industrial marketing.
    Dynamic Effectiveness - Improved Industrial Distribution from Interaction between Marketing and Logistics Strategies2004In: Journal of Distribution Channels, ISSN 1046-669X, E-ISSN 1540-7039, Vol. 12, no 2, p. 83-112Article in journal (Refereed)
  • 240.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Brege, Staffan
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Industrial marketing.
    Norrman, Andreas
    Lunds universitet.
    Distribution Channel Reengineering - organizational separation of distribution and sales functions in the European market1998In: Transport Logistics, ISSN 0929-9645, E-ISSN 1568-5705, Vol. 1, no 4, p. 237-249Article in journal (Refereed)
  • 241.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Christopher, Martin
    Cranfield School of Management, Cranfield, Bedford, UK.
    Stensson, Bo-Inge
    SKF, Sverige.
    Mastering Supply Chain Management in an era of uncertainty at SKF2015In: Global Business and Organizational Excellence: a review of research & best practices, ISSN 1932-2054, Vol. 34, no 6, p. 6-17Article in journal (Other academic)
    Abstract [en]

    To stay ahead in an increasingly competitive business environment, organizations need agile supply chain systems that are holistically designed and managed. The experiences of SKF, a Swedish multinational firm, point to the benefits of reengineering upstream capabilities to create value downstream. To foster the flexibility, responsiveness, and other dynamic capabilities needed to manage increased supply chain complexity, the company established programs to involve its suppliers in the value creation process, making them an extension of the organization’s resource base. The overall objective has been to migrate from a business model based on economies of scale in operations to one that exploits both economies of scope and economies of integration. As a result of its efforts to create a more agile and cost-efficient supply chain, the company has been able to decrease supply risks while improving its value creation process and responsiveness to new customer demands and advancing its sustainability and social responsibility initiatives. 

  • 242.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Karlöf, Stefan
    Sonat, Sverige.
    Det dynamiska företaget: om följsamhet och flödesorienterade affärsmodeller2011 (ed. 1)Book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Dagens osäkra affärsklimat betraktas av många som ett problem och en risk som måste hanteras. I den här boken vänder författarna på perspektivet och betraktar osäkerheten som en möjlighet till framgång - om företaget har tillräcklig dynamisk förmåga. Den dynamiska förmågan innebär att företaget snabbt kan förändra sin marknadsstrategi och sin dagliga verksamhet. Det kräver en tydlig och flödesorienterad affärsmodell med en effektiv och följsam kedja från leverantör till slutkund. Denna bok presenterar en modell för hur företaget kan uppnå en sådan dynamisk effektivitet och diskuterar hur man kan omsätta den i praktisk handling. Boken vänder sig till chefer och ledningsgrupper i företag som vill utvecklas i takt med omvärldens krav och därmed få bäst förutsättningar att överleva och växa i det krävande affärsklimatet - survival of the fittest!

  • 243.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Malmgren, Mike
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Andersson, Dan
    Chalmers.
    Inside the Core: Managing risks in Business Critical Outsourcing2011In: Proceedings of the 20th Annual IPSERA Conference, Vision 20/20 – Preparing Today for Tomorrow’s Challenges / [ed] F. Rozemeijer, M. Wetzels, L. Quintens, 2011, p. 1092-1101Conference paper (Refereed)
    Abstract [en]

    Organizations are increasingly outsourcing business critical activities, which increases the risk of substantial negative impact on the financial and strategic business performance. The aim of this paper is to show how outsourcer and supplier seek to mitigate the risks during the negotiations and the ongoing operations of the outsourced activities. The conclusion is that risk mitigating dimensions are directional and operates at different organizational levels, and secondly, that the dimension operates sequentially as a means to mitigate performance and relational risks. It is also concluded that goodwill trust and a cooperative stance have substantial impact on the success of the outsourcing.

  • 244.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Malmgren, Mike
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Andersson, Dan
    Chalmers.
    Managing risk in complex and business critical outsourcing of services2011In: Proceedings of 18th International Annual Conference of the European Operations Management Association. EurOMA, 2011Conference paper (Refereed)
    Abstract [en]

    Over the past two decades the phenomenon of outsourcing of resources and activities has emerged as an important trend in a wide range of organizations and many companies are today outsourcing complex and business critical resources and activities. This increase in business criticality also increases the risk of substantial and negative impact on the financial and strategic performance. The proposition is that business critical outsourcing is approached with a joint risk perspective and that an understanding of the decision process is essential for success. Further, it is important to view outsourcing as an ongoing process with a number of key stages.

  • 245.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Rehme, Jakob
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    The Role of Logistics in Retailers' Corporate Strategy: A Driver for Growth and Customer Value2010In: Supply Chain Forum: an International Journal, ISSN 1625-8312, E-ISSN 1624-6039, Vol. 11, no 4, p. 14-23Article in journal (Refereed)
    Abstract [en]

    This article explores the role of logistics and supply chain management (SCM) in retailers’ corporate strategy and is based on reviewing multiple qualitative case studies of companies in the Swedish food retail sector. The article proposes that the role of logistics for what is referred to in this paper as modern retailers is twofold: to create profitability and to support growth and market expansion. International modern retailers are empirically compared with similar companies in the Swedish market. The dominating Swedish food retailers have taken command in the food supply chain but are primarily concerned with traditional logistics roles in cost cutting. This role is perfectly fine as long as the strategic intent of the companies is focused on market retention and not on geographical expansion and/or new marketing or store concepts. We argue that the success of modern retailers in terms of growth rate, profitability, and market expansion is explained to a large extent by the role of logistics in corporate strategy—when the role for supporting growth and increasing customer value from high-performance supply capabilities is a driver for market expansion. However, in many of our cases the traditional logistics roles of cutting costs and lead-times is still the dominating pattern that limits the possibility of expanding into new markets. Better knowledge of logistics’ role in retail corporate strategy can help companies develop and improve their strategic intent as well as redefine the role of logistics.

  • 246.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Rehme, Jakob
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Sandberg, Erik
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Olle, Olsson
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    The Role of Buying Groups in Retail Logistics2010Conference paper (Refereed)
  • 247.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Rehme, Jakob
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Sandberg, Erik
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Olsson, Olle
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    The role of purchasing groups in retail logistics2012In: Nordic Retail Research: Emerging Diversity / [ed] Johan Hagberg, Ulrika Holmberg, Malin Sundström, Lars Walter, Göteborg: Bokförlaget BAS , 2012, 1, p. 155-172Chapter in book (Other academic)
    Abstract [en]

    This book aims to provide an illustration of the diversity that characterises contemporary Nordic research in the field of retail. The book draws on a large variety of methods, describes a variety of retail sectors and covers a large number of retail phenomena. The book is suitable for researchers, graduate students and professionals who want to learn more about contemporary retailing research

  • 248.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Sandberg, Erik
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Rehme, Jakob
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Logistik i svensk handel: Ett projekt finansierat av Handelns Utvecklingsråd2011Report (Other academic)
    Abstract [sv]

    Den här rapporten sammanfattar ett forskningsprojekt, Logistik i svensk handel, som har pågått under perioden juli 2009 t.o.m. februari 2011 och som är finansierat av Handelns Utvecklingsråd.

    En utgångspunkt och hypotes för projektet var att det finns avgörande branschmässiga skillnader i sättet att arbeta med logistikfrågor. En hypotes som har testats mot empirin, vilket har lett till slutsatsen att logistiken endast i begränsad omfattning är branschspecifik och att branschtillhörighet inte är den avgörande faktorn för hur logistiken utformas för handelsföretag. En viktigare faktor, är hur butikerna drivs visavi centrala enheter, hur integrationen ser ut mellan logistikstrategi och inköps- respektive marknadsstrategi, samt hur systemgränserna för logistiken definieras.

    Genom hela arbetet har vi jämfört den logistikbild vi har sett med en ”ideal bild”, i form av logistiken i internationell ”mega-retailing”, vilket idag representerar ”best practice” inom logistik och där logistiken är en integrerad del av företagens affärsmodell och ett direkt stöd för företagets lönsamhet och tillväxt. Den jämförelsen visar att det är mycket stora skillnader i logistikkompetens och mognad mellan olika företag och att logistik inom många handelsföretag fortfarande är ett område med stor förbättringspotential.

    Förutom den här rapporten har projektet genererat en lång rad akademiska artiklar som är publicerade i journaler och/eller har presenterats på konferenser och seminarier. Vi har varit i kontakt med ett stort antal, kollegor, företag och forskare i Sverige och andra länder för att samla material. Ett stort tack till alla de som har bidragit med material till projektet.

    Ett speciellt tack till Andreas Hedlund på Handelns Utvecklingsråd, som förutom finansiellt stöd har backat upp projektet med seminarier arrangerade av Handelns utvecklingsråd.

    Linköping i Maj 2011

    Mats Abrahamsson   Jakob Rehme   Erik Sandberg

  • 249.
    Abrahamsson, Mats
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Stahre, Fredrik
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Huge-Brodin, Maria
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Rehme, Jakob
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Andersson, Dan
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Logistics Changes and Challenges in Swedish Food Supply Chains2008In: Nofoma 2008, 2008Conference paper (Refereed)
  • 250.
    Abrahamsson, Mats
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Economics, Logistics.
    Wandel, Sten
    Lunds universitet.
    Model of Tiering in Third Party Logistics with a Service Parts Distribution Case Study1998In: Transport Logistics, ISSN 0929-9645, E-ISSN 1568-5705, Vol. 1, no 3, p. 181-194Article in journal (Refereed)
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