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  • 201.
    Domi, Esi
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Univ Camerino, Italy.
    Caputi, Francesca Felicia
    Alma Mater Studiorum Univ Bologna, Italy.
    Romualdi, Patrizia
    Alma Mater Studiorum Univ Bologna, Italy.
    Domi, Ana
    Univ Camerino, Italy.
    Scuppa, Giulia
    Univ Camerino, Italy.
    Candeletti, Sanzio
    Alma Mater Studiorum Univ Bologna, Italy.
    Atkins, Alison Lynn
    Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
    Heilig, Markus
    Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Psykiatriska kliniken inkl beroendekliniken.
    Demopulos, Gregory
    Omeros Corp, WA 98101 USA.
    Gaitanaris, George
    Omeros Corp, WA 98101 USA.
    Ciccocioppo, Roberto
    Univ Camerino, Italy.
    Ubaldi, Massimo
    Univ Camerino, Italy.
    Activation of PPAR gamma Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission2019In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 39, no 49, p. 9864-9875Article in journal (Refereed)
    Abstract [en]

    An isoform of peroxisome proliferator-activated receptors (PPARs), PPAR gamma, is the receptor for the thiazolidinedione class of antidiabetic medications including pioglitazone. Neuroanatomical data indicate PPAR gamma localization in brain areas involved in drug addiction. Preclinical and clinical data have shown that pioglitazone reduces alcohol and opioid self-administration, relapse to drug seeking, and plays a role in emotional responses. Here, we investigated the behavioral effect of PPAR gamma manipulation on nicotine withdrawal in male Wistar rats and in male mice with neuron-specific PPAR gamma deletion (PPAR gamma(()(+/+)())) and their littermate wild-type (PPAR gamma((-/-))) controls. Real-time quantitative RT-PCR and RNAscope in situ hybridization assays were used for assessing the levels of expression and cell-type localization of PPAR gamma function, Memory, Mortality, Older subjects, Structural brain abnormalities during nicotine withdrawal. Brain site-specific microinjections of the PPAR gamma agonist pioglitazone were performed to explore the role of this system on nicotine withdrawal at a neurocircuitry level. Results showed that activation of PPAR gamma by pioglitazone abolished the expression of somatic and affective nicotine withdrawal signs in rats and in (PPAR gamma(()(+/+)())) mice. This effect was blocked by the PPAR gamma antagonist GW9662. During early withdrawal and protracted abstinence, the expression of PPAR gamma increased in GABAergic and glutamatergic cells of the amygdala and hippocampus, respectively. Hippocampal microinjections of pioglitazone reduced the expression of the physical signs of withdrawal, whereas excessive anxiety associated with protracted abstinence was prevented by pioglitazone microinjection into the amygdala. Our results demonstrate the implication of the neuronal PPAR gamma in nicotine withdrawal and indicates that activation of PPAR gamma may offer an interesting strategy for smoking cessation.

  • 202.
    Lee, Chih Feng
    et al.
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, Faculty of Science & Engineering.
    Manzie, Chris
    University of Melbourne, Australia.
    Active Brake Judder Attenuation Using an Electromechanical Brake-by-Wire System2016In: IEEE/ASME transactions on mechatronics, ISSN 1083-4435, E-ISSN 1941-014X, Vol. 21, no 6, p. 2964-2976Article in journal (Refereed)
    Abstract [en]

    Brake judder is an undesirable phenomenon in passenger vehicles whereby disk thickness variations lead to brake torque variations (BTVs) during light braking events with a consequence of reduced braking performance and driver satisfaction. Most solutions involve passive approaches; however, in this study, a novel active brake judder attenuation strategy utilizing the capabilities of a prototype electromechanical brake (EMB) is proposed. Two attenuation algorithms with different sensor requirements are presented, where compensating clamp force commands are generated to cancel the judder causing BTV arises during light braking. The first approach is founded on the linear parameter-varying (LPV) control structure, which is designed using the output regulation theory and scheduled using wheel angular speed and acceleration. The second approach examines the adaptive feedforward compensation, where the compensator is scheduled using wheel angular position, speed, and acceleration. Experimental investigations showed favorable results for the LPV compensator, albeit with high sampling rate requirements. On the other hand, the adaptive compensator demonstrated lower sampling rate requirements with better BTV attenuation, but required wheel position measurements. These results highlight the applicability of EMBin judder reduction and the advantage of having wheel measurements.

  • 203.
    Kucher, Kostiantyn
    et al.
    Linnéuniversitetet, Institutionen för datavetenskap (DV).
    Paradis, Carita
    Lund University.
    Sahlgren, Magnus
    Swedish Research Institute (RISE SICS).
    Kerren, Andreas
    Linnéuniversitetet, Institutionen för datavetenskap (DV).
    Active Learning and Visual Analytics for Stance Classification with ALVA2017In: ACM Transactions on Interactive Intelligent Systems, ISSN 2160-6455, E-ISSN 2160-6463, Vol. 7, no 3, article id 14Article in journal (Refereed)
    Abstract [en]

    The automatic detection and classification of stance (e.g., certainty or agreement) in text data using natural language processing and machine learning methods create an opportunity to gain insight into the speakers' attitudes towards their own and other people's utterances. However, identifying stance in text presents many challenges related to training data collection and classifier training. In order to facilitate the entire process of training a stance classifier, we propose a visual analytics approach, called ALVA, for text data annotation and visualization. ALVA's interplay with the stance classifier follows an active learning strategy in order to select suitable candidate utterances for manual annotation. Our approach supports annotation process management and provides the annotators with a clean user interface for labeling utterances with multiple stance categories. ALVA also contains a visualization method to help analysts of the annotation and training process gain a better understanding of the categories used by the annotators. The visualization uses a novel visual representation, called CatCombos, which groups individual annotation items by the combination of stance categories. Additionally, our system makes a visualization of a vector space model available that is itself based on utterances. ALVA is already being used by our domain experts in linguistics and computational linguistics in order to improve the understanding of stance phenomena and to build a stance classifier for applications such as social media monitoring.

  • 204.
    Gaipov, Abduzhappar
    et al.
    University of Tennessee Health Science Center, Memphis, TN, USA, National Scientific Medical Research Center, Astana, Kazakhstan.
    Molnar, Miklos Z
    University of Tennessee Health Science Center, Memphis, TN, USA, Semmelweis University, Budapest, Hungary.
    Potukuchi, Praveen K
    University of Tennessee Health Science Center, Memphis, TN, USA.
    Sumida, Keiichi
    University of Tennessee Health Science Center, Memphis, TN, USA,Toranomon Hospital Kajigaya, Kanagawa, Japan..
    Szabó, Zoltán
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
    Akbilgic, Oguz
    University of Tennessee Health Science Center, Memphis, TN, USA.
    Streja, Elani
    University of California, Irvine, Orange, CA, USA..
    Rhee, Connie M
    University of California, Irvine, Orange, CA, USA..
    Koshy, Santhosh K G
    University of Tennessee Health Science Center, Memphis, TN, USA.
    Canada, Robert B
    University of Tennessee Health Science Center, Memphis, TN, USA.
    Kalantar-Zadeh, Kamyar
    University of California, Irvine, Orange, CA, USA..
    Kovesdy, Csaba P
    University of Tennessee Health Science Center, Memphis, TN, USA, Memphis VA Medical Center, Memphis, TN, USA.
    Acute kidney injury following coronary revascularization procedures in patients with advanced CKD.2019In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 34, no 11, p. 1894-1901Article in journal (Refereed)
    Abstract [en]

    Background: Previous studies reported that compared with percutaneous coronary interventions (PCIs), coronary artery bypass grafting (CABG) is associated with a reduced risk of mortality and repeat revascularization in patients with mild to moderate chronic kidney disease (CKD) and end-stage renal disease (ESRD). Information about outcomes associated with CABG versus PCI in patients with advanced stages of CKD is limited. We evaluated the incidence and relative risk of acute kidney injury (AKI) associated with CABG versus PCI in patients with advanced CKD.

    Methods: We examined 730 US veterans with incident ESRD who underwent a first CABG or PCI up to 5 years prior to dialysis initiation. The association of CABG versus PCI with AKI was examined in multivariable adjusted logistic regression analyses.

    Results: A total of 466 patients underwent CABG and 264 patients underwent PCI. The mean age was 64 ± 8 years, 99% were male, 20% were African American and 84% were diabetic. The incidence of AKI in the CABG versus PCI group was 67% versus 31%, respectively (P < 0.001). The incidence of all stages of AKI were higher after CABG compared with PCI. CABG was associated with a 4.5-fold higher crude risk of AKI {odds ratio [OR] 4.53 [95% confidence interval (CI) 3.28-6.27]; P < 0.001}, which remained significant after multivariable adjustments [OR 3.50 (95% CI 2.03-6.02); P < 0.001].

    Conclusion: CABG was associated with a 4.5-fold higher risk of AKI compared with PCI in patients with advanced CKD. Despite other benefits of CABG over PCI, the extremely high risk of AKI associated with CABG should be considered in this vulnerable population when deciding on the optimal revascularization strategy.

  • 205.
    Juhola, Sirkku
    et al.
    Helsinki University, Finland.
    Goodsite, M.E.
    University of Southern Denmark, Denmark.
    Davis, M.
    Stockholm Environment Institute US Centre, USA.
    Klein, Richard J.T.
    Linköping University, Department of Thematic Studies, Centre for Climate Science and Policy Research. Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Stockholm Environment Institute, Sweden.
    Davídsdóttir, B.
    University of Iceland, Iceland.
    Atlason, R.
    University of Iceland, Iceland.
    Landauer, Mia
    Aalto University, Finland.
    Linnér, Björn-Ola
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Thematic Studies, Centre for Climate Science and Policy Research.
    Neset, Tina Schmid
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Thematic Studies, Centre for Climate Science and Policy Research.
    Glaas, Erik
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Thematic Studies, Centre for Climate Science and Policy Research.
    Eskeland, Gunnar
    Norwegian School of Economics, Norway.
    Gammelgaard Ballantyne, Anne
    Aarhus University, Denmark.
    Adaptation decision-making in the Nordic countries: assessing the potential for joint action2014In: Environment Systems and Decisions, ISSN 2194-5403, E-ISSN 2194-5411, Vol. 34, no 4, p. 600-611Article in journal (Refereed)
    Abstract [en]

    In a global context, the outlook for the Nordic region is relatively favourable, given its relatively stronger resiliency to climate change impacts in comparison to many other geo-political regions of the world. Overall, the projected climatic changes include increases in mean temperatures and in precipitation, although regional variations can be significant. The countries’ robust institutions and economies give them a strong capacity to adapt to these changes. Still, the need for adaptation to the changing climate has been and still is substantial, and in most of the region, there has been progress on the issue. This paper explores the potential for Nordic cooperation on adaptation; specifically, for the development of a regional adaptation strategy. In particular, it addresses two questions (1) What is the current state of adaptation in the Nordic countries? and (2) What are the potential benefits and weaknesses of a Nordic strategy for adaptation? In order to answer these two questions, this paper examines reviews the current national adaptation policies of each Nordic country and discusses the challenges facing a Nordic strategy and finally assesses the potential for common Nordic adaptation policy and further cooperation.

  • 206. Order onlineBuy this publication >>
    Johansson, Pontus
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, The Institute of Technology.
    Adapting manufacturing strategy to industrial after-sales service operations2006Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This dissertation is initiated from an increased awareness within industry of the importance of services in general and of after-sales services in particular. The scope of this research is to analyse how the specific characteristics of after-sales services affect a company’s manufacturing strategy, which in effect should become an operations strategy not only considering the manufacturing of goods. Considering the after-sales service as a product, consisting of both good and service characteristics, the objective of this dissertation is to develop conceptual models for an improved long-term management of operations where production of both new goods and after-sales services are competing for the same or similar resources. Specifically, the structural decision categories of a manufacturing strategy, process technology, capacity, facilities, and vertical integration, are adapted to include the demands of after-sales service products.

    The research result is an extension of the existing manufacturing strategy framework, which is transformed towards a more general operations strategy framework capable of providing managerial guidance for a larger set of products than just pure goods. Tools are developed for analysing what processes would be suitable for the after-sales services, and whether the after-sales processes should be merged with, or separated from, the new goods process. An extended long term service capacity framework is also introduced, looking specifically at the needs of after-sales service operations. Through seven case studies as well as a survey of 45 Italian providers of both manufactured goods and services, the after-sales supply chain is mapped and classified with respect to vertical integration and facilities.

    List of papers
    1. Industrial service profiling: Matching service offerings and processes
    Open this publication in new window or tab >>Industrial service profiling: Matching service offerings and processes
    2004 (English)In: International Journal of Production Economics, ISSN 0925-5273, E-ISSN 1873-7579, Vol. 89, no 3, p. 309-320Article in journal (Refereed) Published
    Abstract [en]

    Firms using industrial goods as a resource in their own operations need support and services to maintain an efficient use of these resources. Education, spare parts and maintenance are just some examples of services required by many industrial customers. These services make up a large part of many industrial companies purchase budget, but, even more importantly, for the supplier these services often make up a substantial proportion of the company's profit. There is also a trend towards the integration of goods and services. However, there is little help available on strategies for the efficient supply or manufacture of such services. An operations strategy should not be limited to supporting just new sales if the after-sales market of industrial services has a large impact on the company's competitive advantage. A complete operations strategy should therefore be linked not only to the marketing strategy, but also to a service strategy of the company. In this paper we take the supplier's view on the task of providing industrial services, i.e. the supply of after-sales services, including tangibles such as spare parts and consumables, related to the maintenance of industrial goods. We focus on the positioning of industrial services relative manufacturing, aiming at an integrated approach for manufacturing and service operations management. We extend the product-profiling concept of Hill to service operations, developing the concept of industrial service profiling, providing a detailed analysis of market and service offering characteristics relative production characteristics. The resulting profile reveals possible mismatches in the existing operations, and can also be used to identify areas in need of corrective actions.

    Keywords
    Produktionsstrategi
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-22470 (URN)10.1016/S0925-5273(03)00028-8 (DOI)1713 (Local ID)1713 (Archive number)1713 (OAI)
    Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
    2. Linking product-process matrices for manufacturing and service operations
    Open this publication in new window or tab >>Linking product-process matrices for manufacturing and service operations
    2006 (English)In: International Journal of Production Economics, ISSN 0925-5273, Vol. 104, no 2, p. 615-624Article in journal (Refereed) Published
    Abstract [en]

    Firms using industrial goods as a resource in their own operations need support and services to maintain the efficient use of these resources. The prevailing trend is to integrate goods and services in a product package. We take the supplier's view on the task of providing industrial services, i.e. the supply of after-sales services, including tangibles such as spare parts and consumables, related to industrial goods. We study the relationship between goods manufacturing and industrial services, aiming at an integrated approach for manufacturing and service operations decisions on process choice. In this paper, we specifically explore the linkage between goods manufacturing and service operations product–process matrices. Product, market demand and process characteristics can develop differently for industrial services relative to the manufactured good, wherefore it is important to analyse volume, variety and process issues for both manufacturing and service operations, respectively, in order to create a match between product and process characteristics. We derive a framework for process choice in joint manufacturing and after-sales service operations, and illustrate with an industrial case study.

    Keywords
    After-sales service; Manufacturing and service operations management; Product–process matrix
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13879 (URN)10.1016/j.ijpe.2005.12.008 (DOI)
    Available from: 2006-09-08 Created: 2006-09-08
    3. Long-term capacitymanagement for integrated manufacturing and service operations
    Open this publication in new window or tab >>Long-term capacitymanagement for integrated manufacturing and service operations
    2006 (English)In: Omega, ISSN 0030-2228, E-ISSN 1541-3764Article in journal (Other academic) Submitted
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:liu:diva-52939 (URN)
    Available from: 2010-01-13 Created: 2010-01-13 Last updated: 2017-12-12
    4. Configuring the after-sales service supply chain: A multiple case study
    Open this publication in new window or tab >>Configuring the after-sales service supply chain: A multiple case study
    2007 (English)In: International Journal of Production Economics, ISSN 0925-5273, E-ISSN 1873-7579, Vol. 110, no 1-2, p. 52-69Article in journal (Refereed) Published
    Abstract [en]

    After-sales service in firms manufacturing and selling durable goods has a strategic relevance in its potential contribution to company profitability, customer retention and product development. This paper addresses the configuration of the after-sales supply chain. Three configuration choices are analysed: The degree of vertical integration, the degree of centralisation, and the decoupling of activities (i.e. how activities are decomposed and separated organisationally). Exploratory case study research was performed over seven companies belonging to durable consumer goods industries. The empirical findings show that configuration choices vary, suggesting that no “one best way” exists. Moreover, many firms develop multiple configurations. Choices are influenced by drivers, including the attractiveness of the after-sales business, the strategic priorities, the characteristics of the physical product and the services offered, and the configuration of the manufacturing and distribution supply chain. The paper discusses how these drivers may lead to consistent configuration choices, and how choices are related.

    Keywords
    After-sales service, Supply chain configuration, Durable consumer goods, Case study
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13881 (URN)10.1016/j.ijpe.2007.02.009 (DOI)
    Available from: 2006-09-08 Created: 2006-09-08 Last updated: 2017-12-13
    5. The after-sales service, aligning supply chain configuration with strategy: evidence from the household appliance industry”
    Open this publication in new window or tab >>The after-sales service, aligning supply chain configuration with strategy: evidence from the household appliance industry”
    2005 (English)In: 12th European Operations Management Association Conference in Budapest, Hungary, June 2005, 2005Conference paper, Published paper (Other academic)
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13882 (URN)
    Available from: 2006-09-08 Created: 2006-09-08 Last updated: 2009-06-01
    6. Adapting manufacturing strategy to the increased service content of products
    Open this publication in new window or tab >>Adapting manufacturing strategy to the increased service content of products
    2006 (English)In: 14th International Working Seminar on Production Economics in Innsbruck, Austria, February, 2006Conference paper, Published paper (Other academic)
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13883 (URN)
    Available from: 2006-09-08 Created: 2006-09-08 Last updated: 2009-02-27
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  • 207.
    Johansson, Pontus
    Linköping University, Department of Management and Engineering, Production Economics . Linköping University, The Institute of Technology.
    Adapting manufacturing strategy to the increased service content of products2006In: 14th International Working Seminar on Production Economics in Innsbruck, Austria, February, 2006Conference paper (Other academic)
  • 208.
    Ris, Inge
    et al.
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense M, Denmark.
    Schröder, Karin
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Kongsted, Alice
    Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense M, Denmark; Chiropractic Knowledge Hub, Odense M, Denmark.
    Abbott, Allan
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Nilsen, Per
    Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Health, Medicine and Caring Sciences, Division of Society and Health.
    Hartvigsen, Jan
    Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense M, Denmark; Chiropractic Knowledge Hub, Odense M, Denmark.
    Öberg, Birgitta
    Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine.
    Adapting the determinants of implementation behavior questionnaire to evaluate implementation of a structured low back pain programme using mixed-methods2021In: Health Science Reports, E-ISSN 2398-8835, Vol. 4, no 2, article id e266Article in journal (Refereed)
    Abstract [en]

    Background and Aims: Best-practice low back pain (LBP) primary care programmes have been developed based on evidence-based clinical guidelines and implemented in Sweden and Denmark. The theoretical domains framework (TDF) was utilized in the design of the implementation strategy. Based on the TDF domains, the Determinants of Implementation Behavior Questionnaire (DIBQ) has been developed to evaluate implementation determinants, but its feasibility and validity need to be tested and adapted to study specific contexts. This study aimed to tailor the DIBQ for evaluation of implementation for LBP primary care programmes. The objectives were to (a) translate the DIBQ into Swedish and Danish, (b) adapt the DIBQ into DIBQ-tailored (DIBQ-t) to study content validity, (c) test the DIBQ-t for feasibility, and (d) perform validity testing of DIBQ-t.

    Methods: We used a mixed-methods design. First, forward translation of the DIBQ, then adaptation into DIBQ-t using qualitative face validity and quantitative content validity was done. Finally, to determine feasibility and construct validity using confirmatory factor analyses, we used data from DIBQ-t collected after the programmes' 2-day course.

    Results: The final DIBQ-t included 28 items describing 10 of the original 18 DIBQ domains and was considered feasible. A total of 598 clinicians out of 609 responded to the DIBQ-t, with only 2‰ of the items missing. The confirmatory factor analyses showed a good fit after removing two items with the lowest domain loading. The DIBQ-t maintained linkage to all domains within the Behavioral Change Wheel. The clinicians' expectations, according to the DIBQ-t, indicate facilitating determinants outweighing barriers at the initiation of implementation processes.

    Conclusions: The study resulted in a feasible and valid version of a questionnaire for evaluating clinicians' expectations regarding implementation determinants of best-practice LBP primary care programmes.

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  • 209.
    Falk, Karolina
    et al.
    Linköping University, Department of Management and Engineering, Energy Systems. Linköping University, The Institute of Technology.
    Forsberg, Joel
    Linköping University, Department of Management and Engineering, Energy Systems. Linköping University, The Institute of Technology.
    Adapting to the Changes Enforced by EU’s Network Codes for Electricity: The Consequences for an Electricity Company from a Distribution System Operator’s Perspective2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    To reach EU’s climate and energy target an integrated electricity market is considered to be required (Klessmann, et al., 2011; Boie, et al., 2014; Becker, et al., 2013). As a result the European Commission decided to form a set of rules, named the Network Codes, to create a single European market (ENTSO-E, 2013b). The Network Codes will affect Distribution- and Transmission System Operators, grid users and production units as well as all the other actors on the electricity market (Eurelectric, n.d.a). Concerns regarding what the Network Codes’ actual consequences are have been expressed within the line of business (Swedish Energy, 2013a). Therefore the purpose of this master’s thesis was to determine and furthermore illustrate the consequences the Network Codes will have, in current version, for a Swedish non-transmission system connected electricity company and determine what actions need to be taken.

    The purpose has been addressed by conducting interviews, document studies and by utilizing a change management model, the Intervention Strategy Model, introduced by Paton & McCalman (2000). The structured approach that is the nature of the model was used when determining the consequences the Network Codes enforce and what actions a non-transmission system connected electricity company has to take to cope with them. To further facilitate the determination of these actions this study was conducted on a non-transmission system connected electricity company, in this thesis named Electricity Company A.

    The investigation of the concerns expressed within the line of business illustrated that the concerns were diverse but a majority of them might be incorporated into either of the following groups, simulation models, demand side aggregator and information handling. Out of these groups information handling was by far the area of greatest concern with issues primarily connected to the Distribution System Operator. Consequently this thesis focused on the Distribution System Operator’s perspective.

    The analysis of the area of greatest concern, presented in two flow charts, clearly showed the increased amount of communication enforced by the Network Codes. This increased information handling results in numerous possible organisational consequences for the Distribution System Operator, for example might new systems be required and some existing systems be used with or without adaption. Furthermore, the extra workload could possibly be handled by the existing personnel, in some cases after complementary education, but it might also require new personnel. Finally the Network Codes open up for the possibility for the Distribution System Operator to define certain details which may be conducted individually or in cooperation with other Distribution System Operators. Which of these possible consequences that will affect a specific company is, however, dependent on its preconditions.

    The study on Electricity Company A reveals that the numerous actions required to handle the new communication were not as significant as the line of business might have feared. For Electricity Company A, primarily a new system is needed to handle the real-time values and some of the existing systems need to be updated. Additionally the combined extra work load might require extra personnel for Electricity Company A even though the individual work assignments are fairly small. The actions required should be fairly similar for companies of approximately equal size but might be more extensive for smaller non-transmission system connected electricity companies. All companies need, however, to conduct an individual analysis to determine which specific actions are required for them.

    The conclusions of this thesis aspired, and partly succeeded, to be generalizable on a European level. One example of this is the usage of the Intervention Strategy Model which proved applicable for determining which specific actions are required for all European electricity companies. Furthermore the concerns presented and the possible consequences of the increased information handling found, are generalizable but not complete for all European electricity companies. This thesis focused on one part of the complex Network Codes’ consequences and consequently further research is needed to fully understand the consequences for the electricity business in total.

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    Adapting to the Changes Enforced by EU’s Network Codes for Electricity - Falk & Forsberg
  • 210.
    Martinez, Sandra
    et al.
    GLOBOPE Research and Consulting, Spain.
    Errasti, Ander
    NATRA Grp, Spain.
    Rudberg, Martin
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Adapting Zaras Pronto Moda to a value brand retailer2015In: Production planning & control (Print), ISSN 0953-7287, E-ISSN 1366-5871, Vol. 26, no 9, p. 723-737Article in journal (Refereed)
    Abstract [en]

    The clothing sector is currently characterised by frequent assortment rotation in stores, a quick response product development and a focus on minimising end-of-campaign stock levels. This paper is based on a case study carried out at a value brand retailer, with a purpose to show how the company increased competitiveness in a market requiring more responsiveness. The case presented shows that the establishment of an adequate supply strategy for differentiated product segments, the introduction of mini-collections, the redesign of business processes (especially the new product development and the order fulfilment processes) and the redesign of the supply chain, lead to a sales increase and purchasing savings. Moreover, the study treats how a value brand retailer, facing different supply chain challenges compared with the leading brands, balance global and local production, lean and agile manufacturing and how it is possible to abandon the traditional two-campaign paradigm in favour of more rapid replenishment.

  • 211.
    Sivertsson, Martin
    et al.
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Sundström, Christofer
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Eriksson, Lars
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Adaptive Control of a Hybrid Powertrain with Map-based ECMS2011In: Proceedings of the 18th IFAC World Congress, 2011 / [ed] Sergio Bittanti, Angelo Cenedese, Sandro Zampieri, 2011, p. 2949-2954Conference paper (Refereed)
    Abstract [en]

    To fully utilize the fuel reduction potential of a hybrid powertrain requires a careful design of the energy management control algorithms. Here a controller is created using mapbased equivalent consumption minimization strategy and implemented to function without any knowledge of the future driving mission. The optimal torque distribution is calculated oine and stored in tables. Despite only considering stationary operating conditions and average battery parameters, the result is close to that of deterministic dynamic programming. Eects of making the discretization of the tables sparser are also studied and found to have only minor eects on the fuel consumption. The controller optimizes the torque distribution for the current gear as well as assists the driver by recommending the gear that would give the lowest consumption. Two ways of adapting the control according to the battery state of charge are proposed and investigated. One of the adaptive strategies is experimentally evaluated and found to ensure charge sustenance despite poor initial values.

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  • 212.
    Sivertsson, Martin
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Adaptive Control Using Map-Based ECMS for a PHEV2012In: E-COSM'12 -- IFAC Workshop on Engine and Powertrain Control, Simulation and Modeling, 2012, p. 357-362Conference paper (Refereed)
    Abstract [en]

    A plug-in hybrid electric vehicle(PHEV) is a promising way of achieving the benefits of the electric vehicle without being limited by the electric range. This paper develops an adaptive control strategy based on a map-based ECMS approach. The control is developed andimplemented in a simulator provided by IFP Energies nouvelles for the PHEV benchmark. The implemented control strives to be as blended as possible, whilst still ensuring that all electric energy is used in the driving mission. The controller is adaptive to reduce the importance ofcorrect initial values but since the initial values aect the consumption a method is developed to estimate the optimal initial value for the controller based on driving cycle information. This is seen to work well for most driving cycles with promising consumption results. The controller also fulfills all requirements set by the PHEV Benchmark.

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  • 213.
    Pahkasalo, Carolina
    et al.
    Linköping University, Department of Electrical Engineering, Vehicular Systems.
    Sollander, André
    Linköping University, Department of Electrical Engineering, Vehicular Systems.
    Adaptive Energy Management Strategies for Series Hybrid Electric Wheel Loaders2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    An emerging technology is the hybridization of wheel loaders. Since wheel loaders commonly operate in repetitive cycles it should be possible to use this information to develop an efficient energy management strategy that decreases fuel consumption. The purpose of this thesis is to evaluate if and how this can be done in a real-time online application. The strategy that is developed is based on pattern recognition and Equivalent Consumption Minimization Strategy (ECMS), which together is called Adaptive ECMS (A-ECMS). Pattern recognition uses information about the repetitive cycles and predicts the operating cycle, which can be done with Neural Network or Rule-Based methods. The prediction is then used in ECMS to compute the optimal power distribution of fuel and battery power. For a robust system it is important with stability implementations in ECMS to protect the machine, which can be done by adjusting the cost function that is minimized. The result from these implementations in a quasistatic simulation environment is an improvement in fuel consumption by 7.59 % compared to not utilizing the battery at all. 

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  • 214.
    Dastgeer, Usman
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems.
    Li, Lu
    Linköping University, Department of Computer and Information Science, Software and Systems.
    Kessler, Christoph
    Linköping University, Department of Computer and Information Science, Software and Systems.
    Adaptive Implementation Selection in the SkePU Skeleton Programming Library2013In: Advanced Parallel Processing Technologies (APPT-2013), Proceedings / [ed] Chengyung Wu and Albert Cohen (eds.), 2013, p. 170-183Conference paper (Refereed)
    Abstract [en]

    In earlier work, we have developed the SkePU skeleton programming library for modern multicore systems equipped with one or more programmable GPUs. The library internally provides four types of implementations (implementation variants) for each skeleton: serial C++, OpenMP, CUDA and OpenCL targeting either CPU or GPU execution respectively. Deciding which implementation would run faster for a given skeleton call depends upon the computation, problem size(s), system architecture and data locality.

    In this paper, we present our work on automatic selection between these implementation variants by an offline machine learning method which generates a compact decision tree with low training overhead. The proposed selection mechanism is flexible yet high-level allowing a skeleton programmer to control different training choices at a higher abstraction level. We have evaluated our optimization strategy with 9 applications/kernels ported to our skeleton library and achieve on average more than 94% (90%) accuracy with just 0.53% (0.58%) training space exploration on two systems. Moreover, we discuss one application scenario where local optimization considering a single skeleton call can prove sub-optimal, and propose a heuristic for bulk implementation selection considering more than one skeleton call to address such application scenarios.

  • 215.
    Dhar, Abhishek
    et al.
    Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
    Bhasin, Shubhendu
    Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
    Adaptive MPC for Uncertain Discrete-Time LTI MIMO Systems with Incremental Input Constraints2018Conference paper (Other academic)
    Abstract [en]

    In this paper, an adaptive model predictive control (MPC) strategy is proposed for controlling a discrete-time linear MIMO system with parametric uncertainties and subjected to actuator constraints. Compared to previous results in literature which either solve the constrained MPC problem for stable uncertain systems or the unconstrained MPC problem for unstable uncertain systems, this result, presents a solution approach for constrained MPC problems for fully uncertain and unstable systems. An adaptive law, designed to update the estimated parameters of the plant, is combined with a constrained MPC for an estimated system. A sufficient condition is imposed on the adaptation gain to account for feasibility of the MPC optimization problem in the presence of the actuator constraint. Stability analysis of the closed loop system with the proposed adaptive MPC strategy has been shown to guarantee the ultimate boundedness of parameter estimation errors and boundedness as well as asymptotic convergence of the tracking errors to zero.

  • 216.
    Li, Lu
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Dastgeer, Usman
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Kessler, Christoph
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Adaptive Off-Line Tuning for Optimized Composition of Components for Heterogeneous Many-Core Systems2013In: High Performance Computing for Computational Science - VECPAR 2012 / [ed] Dayde, Michel, Marques, Osni, Nakajima, Kengo, Springer, 2013, p. 329-345Conference paper (Refereed)
    Abstract [en]

    In recent years heterogeneous multi-core systems have been given much attention. However, performance optimization on these platforms remains a big challenge. Optimizations performed by compilers are often limited due to lack of dynamic information and run time environment, which makes applications often not performance portable. One current approach is to provide multiple implementations for the same interface that could be used interchangeably depending on the call context, and expose the composition choices to a compiler, deployment-time composition tool and/or run-time system. Using off-line machine-learning techniques allows to improve the precision and reduce the run-time overhead of run-time composition and leads to an improvement of performance portability. In this work we extend the run-time composition mechanism in the PEPPHER composition tool by off-line composition and present an adaptive machine learning algorithm for generating compact and efficient dispatch data structures with low training time. As dispatch data structure we propose an adaptive decision tree structure, which implies an adaptive training algorithm that allows to control the trade-off between training time, dispatch precision and run-time dispatch overhead.

    We have evaluated our optimization strategy with simple kernels (matrix-multiplication and sorting) as well as applications from RODINIA benchmark on two GPU-based heterogeneous systems. On average, the precision for composition choices reaches 83.6 percent with approximately 34 minutes off-line training time.

  • 217.
    Ulvklo, Morgan
    et al.
    n/a.
    Granlund, Gösta H.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Knutsson, Hans
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Adaptive Reconstruction using Multiple Views1998Report (Other academic)
    Abstract [en]

    This report introduces a signal processing strategy for depth segmentation and scene reconstruction that incorporates occlusion as a natural component. The work aims to maximize the use of connectivity in the temporal domain as much as possible under the condition that the scene is static and that the camera motion is known. An object behind the foreground is reconstructed using the fact that different parts of the object have been seen in different images in the sequence. One of the main ideas in the reported work is the use of a spatiotemporal certainty volume c(x) with the same dimension as the input spatiotemporal volume s(x), and then use c(x) as a 'blackboard' for rejecting already segmented image structures. The segmentation starts with searching for image structures in the foreground, eliminates their occluding influence, and then proceeds. Normalized convolution, which is a Weighted Least Mean Square technique for filtering data with varying spatial reliability, is used for all filtering. High spatial resolution near object borders is achieved and only neighboring structures with similar depth supports each other.

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  • 218.
    Ulvklo, Morgan
    et al.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Granlund, Gösta H.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Knutsson, Hans
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Adaptive Reconstruction Using Multiple Views1998In: Proceedings of the IEEE Southwest Symposium on Image Analysis and Interpretation: Tucson, Arizona, USA, 1998, p. 47-52Conference paper (Refereed)
    Abstract [en]

    This paper introduces a novel algorithm for extracting the optical flow obtained from a translating camera in a static scene. Occlusion between objects is incorporated as a natural component in a scene reconstruction strategy by first evaluate and reconstruct the foreground and then exclude its influence on the partly occluded objects behind.

  • 219.
    Fritzson, D.
    et al.
    SKF Nova AB, Chalmers Teknikpark, 412 88, Göteborg, Sweden.
    Nordling, P.
    Adaptive scheduling strategy optimizer for parallel rolling bearing simulation2000In: Future generations computer systems, ISSN 0167-739X, E-ISSN 1872-7115, Vol. 16, no 5, p. 563-570Article in journal (Refereed)
    Abstract [en]

    Rolling bearing simulations are very computationally intensive and need to utilize the potential of parallel computing. The load distribution over the processors in a rolling bearing simulation is very dynamic. In this paper we present the Adaptive Scheduling Strategy Optimizer (ASSO) for scheduling parallel simulations. The result of this is that the application can automatically select a near optimal scheduling strategy (with respect to the available scheduling strategies). The ASSO is used daily in real bearing simulations.

  • 220.
    Fritzson, Dag
    et al.
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
    Nordling, Patrik
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    Adaptive scheduling strategy optimizer for parallel rolling bearing simulation1999In: High-Performance Computing and Networking: 7th International Conference, HPCN Europe 1999 Amsterdam, The Netherlands, April 12–14, 1999 Proceedings / [ed] Peter Sloot, Marian Bubak, Alfons Hoekstra and Bob Hertzberger, Springer Berlin/Heidelberg, 1999, Vol. 1593, p. 99-108Chapter in book (Refereed)
    Abstract [en]

    Rolling bearing simulations are very computationally intensive and need to utilize the potential of parallel computing. The load distribution over the processors in a rolling bearing simulation is very dynamic. In this paper we present the Adaptive Scheduling Strategy Optimizer (ASSO) for scheduling parallel simulations. The result of this is that the application can automatically select a near optimal scheduling strategy (with respect to the available scheduling strategies). The ASSO is used daily in real bearing simulations.

  • 221.
    Kindström, Daniel
    et al.
    Linköping University, Department of Management and Engineering, Industrial Economics. Linköping University, Faculty of Science & Engineering.
    Kowalkowski, Christian
    Department of Marketing, Hanken School of Economics, Helsinki, Finland.
    Brashear Alejandro, Thomas
    University of Massachusetts Amherst, Amherst, USA.
    Adding services to product-based portfolios: Adding services to product-based portfolios: An exploration of the implications for the sales function2015In: Journal of Service Management, ISSN 1757-5818, E-ISSN 1757-5826, Vol. 26, no 3, p. 372-393Article in journal (Refereed)
    Abstract [en]

    Purpose: The objective of this research is to explore the implications for the sales function of the infusion of services by formerly product-based firms. In particular, it aims at identifying the changes that need to be made at the sales-function level if the services are to be successfully sold.Design/Methodology: This research is an exploratory qualitative case study. Data were collected by focus group discussions and in-depth interviews with relevant managers in three large multinational companies based in Northern Europe, which were pursuing service-led growth. Findings: The effects of service infusion processes on the sales function could be seen with respect to the three parts of the analytical framework: organization, roles, and competences. The results illustrate the need for a changed perspective with respect to all three parts, if a product-based firm is to be successful in the infusing of associated services into its portfolio of offerings. Analysis of the results identifies key operational initiatives that management needs to understand and implement when corporate and marketing strategies increasingly focus on service-led growth.Research limitations:The study was exploratory and vendor centric, which means that it did not quantitatively assess the results or directly involve the customers at whom the services were directed. Also, the choice of business-to-business firms limits the capacity to generalize the findings. Originality/Value:Whereas relationship-based and value-based selling are approaches more geared to the sales-force level, the study reported in this paper set out to understand fundamental differences at the sales-function level when firms pursue service-led growth. The findings suggest that the realignment of corporate strategy towards an increased focus on services may have far-reaching implications for the sales function.

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  • 222.
    Klenkar, Goran
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics . Linköping University, The Institute of Technology.
    Brian, Björn
    Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics . Linköping University, The Institute of Technology.
    Ederth, Thomas
    Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics . Linköping University, The Institute of Technology.
    Stengel, Gudrun
    Chalmers.
    Hook, Fredrik
    Chalmers.
    Piehler, Jacob
    University of Frankfurt.
    Liedberg, Bo
    Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics . Linköping University, The Institute of Technology.
    Addressable adsorption of lipid vesicles and subsequent protein interaction studies2008In: BIOINTERPHASES, ISSN 1559-4106, Vol. 3, no 2, p. 29-37Article in journal (Refereed)
    Abstract [en]

    We demonstrate a convenient chip platform for the addressable immobilization of protein-loaded vesicles on a microarray for parallelized, high-throughput analysis of lipid-protein systems. Self-sorting of the vesicles on the microarray was achieved through DNA bar coding of the vesicles and their hybridization to complementary strands, which are preimmobilized in defined array positions on the chip. Imaging surface plasmon resonance in ellipsometric mode was used to monitor vesicle immobilization, protein tethering, protein-protein interactions, and chip regeneration. The immobilization strategy proved highly specific and stable and presents a mild method for the anchoring of vesicles to predefined areas of a surface, while unspecific adsorption to both noncomplementary regions and background areas is nonexistent or, alternatively, undetectable. Furthermore, histidine-tagged receptors have been stably and functionally immobilized via bis-nitrilotriacetic acid chelators already present in the vesicle membranes. It was discovered though that online loading of proteins to immobilized vesicles leads to cross contamination of previously loaded vesicles and that it was necessary to load the vesicles offline in order to obtain pure protein populations on the vesicles. We have used this cross-binding effect to our benefit by coimmobilizing two receptor subunits in different ratios on the vesicle surface and successfully demonstrated ternary complex formation with their ligand. This approach is suitable for mechanistic studies of complex multicomponent analyses involving membrane-bound systems.

  • 223.
    Vlasceanu, Madalina
    et al.
    Department of Psychology, New York University, New York, NY 10003, USA..
    Doell, Kimberly C.
    Department of Psychology, New York University, New York, NY 10003, USA.;Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna 1010, Austria..
    Bak-Coleman, Joseph B.
    Craig Newmark Center for Journalism Ethics and Security, Columbia University, New York, NY 10018, USA.;Institute for Rebooting Social Media, Harvard University, Cambridge, MA 02138, USA..
    Todorova, Boryana
    Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna 1010, Austria..
    Berkebile-Weinberg, Michael M.
    Department of Psychology, New York University, New York, NY 10003, USA..
    Grayson, Samantha J.
    Department of Psychology, Stanford University, Stanford, CA 94305, USA..
    Patel, Yash
    Department of Psychology, New York University, New York, NY 10003, USA..
    Goldwert, Danielle
    Department of Psychology, New York University, New York, NY 10003, USA..
    Pei, Yifei
    Department of Psychology, New York University, New York, NY 10003, USA..
    Chakroff, Alek
    San Luis Obispo, CA 93405, USA..
    Pronizius, Ekaterina
    Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna 1010, Austria..
    van den Broek, Karlijn L.
    Copernicus Institute of Sustainable Development, Utrecht University, Utrecht, 3584 CB, Netherlands..
    Vlasceanu, Denisa
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA..
    Constantino, Sara
    School of Public Policy and Urban Affairs, Northeastern University, Boston, MA 02115, USA.;Department of Psychology, Northeastern University, Boston, MA 02115, USA..
    Morais, Michael J.
    Amazon, Seattle, WA 98109, USA..
    Schumann, Philipp
    Department of Psychology, Carl von Ossietzky University of Oldenburg, Oldenburg 26129, Germany..
    Rathje, Steve
    Department of Psychology, New York University, New York, NY 10003, USA..
    Fang, Ke
    Department of Psychology, New York University, New York, NY 10003, USA..
    Aglioti, Salvatore Maria
    Santa Lucia Foundation, IRCCS, Rome 179, Italy.;Department of Psychology, Sapienza University of Rome, Rome 185, Italy..
    Alfano, Mark
    Department of Philosophy, Macquarie University, Sydney, NSW 2000, Australia..
    Alvarado-Yepez, Andy J.
    Universidad Peruana Cayetano Heredia, San Martín de Porres 15102, Peru..
    Andersen, Angélica
    Post-Graduation Program in Linguistics, Federal University of Paraná, Curitiba 80060150, Brasil..
    Anseel, Frederik
    UNSW Business School, University of New South Wales, Sydney, NSW 2052, Australia..
    Apps, Matthew A. J.
    Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham B15 2TT, UK..
    Asadli, Chillar
    Psychology Scientific Research Institute, Baku, Azerbaijan..
    Awuor, Fonda Jane
    Kenya Marine and Fisheries Research Institute, Kisumu 1881-40100, Kenya..
    Azevedo, Flavio
    Department of Psychology, University of Groningen, Groningen 9712TS, Netherlands..
    Basaglia, Piero
    Department of Economics, University of Hamburg, Hamburg 20146, Germany..
    Bélanger, Jocelyn J.
    Department of Psychology, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates..
    Berger, Sebastian
    Department of Sociology, University of Bern, Bern 3012, Switzerland..
    Bertin, Paul
    LAPCOS, Université Côte d’Azur, Nice 6357, France.;Center for Social and Cultural Psychology, Université libre de Bruxelles, Brussels 1050, Belgium..
    Białek, Michał
    Institute of Psychology, Faculty of Historical and Pedagogical Sciences, University of Wroclaw, Wroclaw 50-120, Poland..
    Bialobrzeska, Olga
    Institute of Psychology, SWPS University, Warsaw 03-815, Poland..
    Blaya-Burgo, Michelle
    Department of Psychology, Division of Behavioral &amp; Organizational Sciences, Claremont Graduate University, Claremont, NH 91711, USA..
    Bleize, Daniëlle N. M.
    Behavioural Science Institute, Radboud University, Nijmegen, 6500 HE, Netherlands..
    Bø, Simen
    Department of Strategy and Management, Norwegian School of Economics, Bergen 5045, Norway..
    Boecker, Lea
    Department of Economic Psychology, Social Psychology and Experimental Methods, Leuphana University Lüneburg, Lüneburg 21335, Germany..
    Boggio, Paulo S.
    Social and Cognitive Neuroscience Laboratory, Mackenzie Presbyterian University, Sao Paulo 1241001, Brazil..
    Borau, Sylvie
    Toulouse Business School, Institute for Advanced Study in Toulouse. Toulouse, 31000, France..
    Bos, Björn
    Department of Economics, University of Hamburg, Hamburg 20146, Hamburg..
    Bouguettaya, Ayoub
    School of Psychology, University of Birmingham, Birmingham B15 2TT, UK..
    Brauer, Markus
    Department of Psychology, University of Wisconsin–Madison, Madison, WI 53706, USA..
    Brick, Cameron
    Department of Psychology, University of Amsterdam, Amsterdam, 1018 WT, Netherlands.;Department of Psychology, Inland Norway University of Applied Sciences, Elverum 2418, Norway..
    Brik, Tymofii
    Policy Research Department, Kyiv School of Economics, Kyiv 2000, Ukraine..
    Briker, Roman
    Department of Organisation, Strategy, and Entrepreneurship, School of Business and Economics, Maastricht University, Maastricht 6211 LK, Netherlands..
    Brosch, Tobias
    Department of Psychology and Swiss Center for Affective Sciences, University of Geneva, Geneva 1205, Switzerland..
    Buchel, Ondrej
    Institute for Sociology of the Slovak Academy of Sciences, Slovak Academy of Sciences, Bratislava 81364, Slovakia..
    Buonauro, Daniel
    Psychological Science, Pomona College, Claremont, CA 91711, USA..
    Butalia, Radhika
    Department of Movement Sciences, KU Leuven, Leuven 3001, Belgium..
    Carvacho, Héctor
    Escuela de Psicología, Pontificia Universidad Católica de Chile, Santiago, Chile..
    Koppel, Lina
    Linköping University, Department of Management and Engineering, Economics. Linköping University, Faculty of Arts and Sciences.
    Västfjäll, Daniel
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Decision Research .
    Tinghög, Gustav
    Linköping University, Department of Management and Engineering, Economics. Linköping University, Faculty of Arts and Sciences.
    Addressing climate change with behavioral science: A global intervention tournament in 63 countries2024In: Science Advances, E-ISSN 2375-2548, Vol. 10, no 6Article in journal (Refereed)
    Abstract [en]

    Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions’ effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2.3%), policy support by writing a letter to a future-generation member (2.6%), information sharing by negative emotion induction (12.1%), and no intervention increased the more effortful behavior—several interventions even reduced tree planting. Last, the effects of each intervention differed depending on people’s initial climate beliefs. These findings suggest that the impact of behavioral climate interventions varies across audiences and target behaviors.

  • 224.
    Valeriani, Giuseppe
    et al.
    Ostergotland Cty Council, Sweden.
    Vukovic, Iris Sarajlic
    Sahlgrens Univ Hosp, Sweden.
    Lindegaard, Tomas
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Felizia, Roberto
    Ostergotland Cty Council, Sweden.
    Mollica, Richard
    Harvard Med Sch, MA 02115 USA.
    Andersson, Gerhard
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Addressing Healthcare Gaps in Sweden during the COVID-19 Outbreak: On Community Outreach and Empowering Ethnic Minority Groups in a Digitalized Context2020In: Healthcare, E-ISSN 2227-9032, Vol. 8, no 4, article id 445Article in journal (Refereed)
    Abstract [en]

    Since its early stages, the COVID-19 pandemic has interacted with existing divides by ethnicity and socioeconomic statuses, exacerbating further inequalities in high-income countries. The Swedish public health strategy, built on mutual trust between the government and the society and giving the responsibility to the individual, has been criticized for not applying a dedicated and more diverse strategy for most disadvantaged migrants in dealing with the pandemic. In order to mitigate the unequal burden on the marginalized members of society, increasing efforts have been addressed to digital health technologies. Despite the strong potential of providing collective public health benefits, especially in a highly digitalized context as Sweden, need for a stronger cooperation between the public health authorities and migrant community leaders, representatives of migrant associations, religious leaders and other influencers of disadvantaged groups has emerged. Suggestions are presented on more culturally congruent, patient-centered health care services aimed to empower people to participate in a more effective public health response to the COVID-19 crisis.

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  • 225.
    Wang, Siqi
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering. Northeastern Univ, Peoples R China.
    Zhang, Bin
    Northeastern Univ, Peoples R China.
    Qiao, Rong-Hao
    Northeastern Univ, Peoples R China.
    Luo, Yan-Wen
    Northeastern Univ, Peoples R China.
    Luo, Xue-Mei
    Chinese Acad Sci, Peoples R China.
    Zhang, Guang-Ping
    Chinese Acad Sci, Peoples R China.
    Adjusting Competitive Reaction to Control Nucleation and Growth of MnO2 for a High-Stress Output Electrochemical Actuator2023In: ACS APPLIED ELECTRONIC MATERIALS, ISSN 2637-6113Article in journal (Refereed)
    Abstract [en]

    Manganese dioxide (MnO2) with biocompatibility has promising applications in low-voltage electrochemical actuators of implantable medical devices, which can convert electrical energy to mechanical motion. However, the unsatisfactory actuation strain restricts the generation of a larger output stress of MnO2 for practical application. Herein, a competitive reaction-driven-MnO2 (CRD-MnO2) nanorod network was fabricated on a nickel (Ni) thin-film substrate by adjusting the component molar ratios. We find that the competitive reaction between 3,4-ethylene-dioxythiophene (EDOT) polymerization and oxidation of Mn2+ controls the nucleation and growth behavior of MnO2. The variation in the electron environment, newly generated oxygen vacancies, and a higher content of structural water effectively improve the electroactivity of MnO2 and simultaneously cause more serious Jahn-Teller (JT) distortion of the crystal octahedrons. Thus, an excellent output performance simultaneously having a much higher actuating strain of 8.3% and an actuation stress of 390.1 MPa is generated during a redox reaction between Mn4+ and Mn3+ under 0-1 V. Moreover, the CRD-MnO2/Ni composite actuating films assembled on a 3D-printed resin model of a human hand with separated finger joints can perform smooth grasping and releasing actions, demonstrating a huge potential for in vitro rehabilitation exercises and implantability for people with finger dyskinesia. This work provides a strategy for actuator material fabrication by controlling a nucleation and growth process by adjusting a competitive reaction.

  • 226.
    Östlund, Gunnel
    et al.
    Mälardalens högskola, Hälsa och välfärd, Sweden.
    Björk, Mathilda
    Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Medical and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Department of Rehabilitation, School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Thyberg, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Rheumatology.
    Valtersson, Eva
    Region Östergötland, Heart and Medicine Center, Department of Rheumatology.
    Sverker, Annette
    Linköping University, Department of Social and Welfare Studies, Social Work. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Activity and Health.
    Adjustment, avoidance, interaction, and acceptance strategies where used by men with participation restrictions due to early RA2015Conference paper (Refereed)
    Abstract [en]

    Background: Approximately 1/3 of patients diagnosed with the chronic disease Rheumatoid Arthritis (RA) are men, however few studies describe experiences and strategies to handle daily activities [2]. Daily life with a chronic disease means learning to live under new circumstances. This also foresee a continuous adaptation to new ways of living. The process of coping in which the individual change the perceived cause of stress as in problem-focused coping or when managing the emotions of stress, as in emotion-focused coping where first mentioned by Lazarus and Folkman [1]. Coping is described as an individual style to handle stressful events that might be changed over time.

    Objectives: The aim was to explore men's strategies for dealing with participation restrictions in everyday life due to early RA.

    Methods: This study is associated with the prospective multi-centre early arthritis project under the Swedish acronym “TIRA-2” [3]. Participants were 25 males of which 22 were work active, mean age 53 years, contemporary treated with mean disease duration of 3 years. Individual interviews were done using the Critical Incident Technique (CIT) [4]. The verbatim transcribed text were analyzed and categorized using content analysis. The study has been approved by the Ethics Committee.

    Results: The men experienced that RA partly required a changed life style and most of them used a combination of strategies to deal with the participation restrictions in relation to RA. In the adjustment strategy new behaviors and tools were used to solve participation restrictions. The avoidance strategy included deliberate avoidance of possible participation restrictions, such as staying at home in the evenings and avoiding socializing with friends. The interaction strategy included to verbally express needs and give demands in relation to others both at work and in the family and ask for help when needed. The acceptance strategy was identified by the wordings used when talking about the experienced participation restrictions as “I accept that everything takes longer time”.

    Conclusions: The interviewed men with early RA were contemporary treated and active in the work force, still, all of them had to deal with some participation restrictions. Moreover, this study claims that most men used a combination of strategies to deal with the experienced participation restriction.

  • 227.
    Soliman, Ahmed
    Linköping University, Department of Management and Engineering, Environmental Technology and Management.
    Adopting Modular Design Strategy towards Circular Economy: A Case Study at a Swedish Original Equipment Manufacturer2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The societal shift towards the circular economy is gaining momentum due to the push from the legislation side and the increasing social awareness towards the ecological imbalance caused by the linear model of resource extraction and consumption. The topic of design for the circular economy is gaining increasing interest in both academia and industry. The circular economy requires products to be designed based on a lifecycle approach and extended lifetime.This thesis aimed to investigate the potential application of modular design strategy as a supportive approach to aid Original Equipment Manufacturers (OEMs) in their bid to adapt their product features to fit within a circular economic model. Furthermore, the study has investigated the potential challenges encountered during the adoption of such a design strategy and concludes with recommendations to overcome the identified challenges.To address this aim, a case study was carried out within a global OEM, based on their interest in exploring the circular economy's design domain. A literature review and interviews have been conducted to assess how product circularity factors can be addressed using a modular design strategy and identifying the potential challenges that can hinder its realization.The study initially identified seven design factors that need to be addressed along the different phases of a product lifecycle to ensure a fit within a circular economic model. The seven circularity factors are design: based on a lifecycle approach, for durability, for adaptability, for upgradability, for ease of maintenance and repair, for ease of disassembly and reassembly, and standardization and compatibility.The study also revealed that a standardized and simplified interface between different modules within the product plays a vital role in enhancing its ability to address the different circularity factors. The standardized interface in the modular product qualifies the product to become useable for multiple usage cycles. Furthermore, such a modular product can be considered an open-source product since it can continuously be updated with the latest available technology. Such continuous updates allow the open-source product to adapt to the changes in the working environment effectively.Despite the capability of a modular design strategy to address the different circularity factors, several challenges can hinder its implementation in the industry. The primary challenge industries face when adopting such a strategy is identifying the main objectives of such an approach. Further, this strategy might negatively impact product profitability, which is a significant challenge for the industries. Moreover, the prospect of adopting modular strategies also faces design challenges, such as the potential of losing customer interest in a modular product.The thesis concludes with a few recommendations to overcome these challenges associated with adopting a modular design strategy for a circular economy. To overcome such challenges, industries need clear identification of the circular economy and the planned outcome of such a manufacturing shift based on clear systems thinking and transparency in product development. In the end, the study proposes a design framework, which may provide industries with a transparent methodology for designing a modular product for a circular economy.

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  • 228.
    Ferguson, Jennifer
    et al.
    Linköping University, Department of Management and Engineering, Business Administration.
    Ukkonen, Merja
    Linköping University, Department of Management and Engineering, Business Administration.
    Adopting Open Innovation: A New Framework for the Analysis of the Open Innovation Adoption Process2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: The term Open Innovation describes a phenomenon where organizations are no longer solely relying on internal R&D to innovate technologies that they then would bring to market. Instead, firms are looking outside for ideas or working with other organizations to develop technologies in order to capitalize on efficiencies of existing knowledge, reduce investment risks and increase speed to market. We identified a need to analyze the existing open innovation adoption frameworks in order to track similarities and differences so that we could create a new framework which is more comprehensive.

    Purpose: The purpose of this thesis is to create a framework for the analysis of the open innovation adoption process which is based on organizational change and other relevant streams of research. In order to do this we were to find answers to the following research questions:

    1) How can organizational change theory be used to analyze the movement from a closed to open innovation strategy?

    2) In addition to organizational change theory, which research streams should be considered when analyzing the open innovation adoption process?

    3) To what extent does our new framework provide an adequate foundation for analyzing the open innovation adoption process at SCA Hygiene Products?

    Results: Our new framework is meant for the analysis of open innovation adoption process. The framework helps researchers to analyze how different organizations have adopted open innovation based on the four research streams that we have analyzed. Our framework includes aspects of organizational change theory, knowledge management, networks and managerial roles.

    Key Words: open innovation adoption, organizational change, knowledge management, networks, SCA

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  • 229.
    Rosenhahn, Axel
    et al.
    Univ Heidelberg, D-69120 Heidelberg, Germany.
    Ederth, Thomas
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics .
    Pettitt, Michala E.
    Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England.
    Advanced nanostructures for the control of biofouling: The FP6 EU Integrated Project AMBIO2008In: BIOINTERPHASES, ISSN 1559-4106, Vol. 3, no 1, p. IR1-IR5Article in journal (Refereed)
    Abstract [en]

    The colonization of man made structures by marine or freshwater organisms or "biofouling" is a problem for maritime and aquaculture industries. Increasing restrictions on the use of toxic coatings that prevent biofouling, create a gap in the market that requires new approaches to produce novel nonbiocidal alternatives. This review details the systematic strategy adopted by an FP6 EU Integrated Project "AMBIO" to develop fundamental understanding of key surface properties that influence settlement and adhesion of fouling organisms. By this approach the project contributes to the understanding of fundamental phenomena involved in biofouling, and to the development of environmentally benign solutions by coating manufacturers within the consortium. (c) 2008 American Vacuum Society.

  • 230.
    Kuhne, Philipp
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Armakavicius, Nerijus
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Stanishev, Vallery
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Herzinger, Craig M,
    J. A. Woollam Company, Inc., Lincoln, NE, USA.
    Schubert, Mathias
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Darakchieva, Vanya
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Advanced Terahertz Frequency-Domain Ellipsometry Instrumentation for In Situ and Ex Situ Applications2018In: IEEE Transactions on Terahertz Science and Technology, ISSN 2156-342X, Vol. 8, no 3, p. 257-270Article in journal (Refereed)
    Abstract [en]

    We present a terahertz (THz) frequency-domain spectroscopic ellipsometer design that suppresses formation of standing waves by use of stealth technology approaches. The strategy to suppress standing waves consists of three elements geometry, coating, and modulation. The instrument is based on the rotating analyzer ellipsometer principle and can incorporate various sample compartments, such as a superconducting magnet, in situ gas cells, or resonant sample cavities, for example. A backward wave oscillator and three detectors are employed, which permit operation in the spectral range of 0.1–1 THz (3.3–33 cm−1 or 0.4–4 meV). The THz frequency-domain ellipsometer allows for standard and generalized ellipsometry at variable angles of incidence in both reflection and transmission configurations. The methods used to suppress standing waves and strategies for an accurate frequency calibration are presented. Experimental results from dielectric constant determination in anisotropic materials, and free charge carrier determination in optical Hall effect (OHE), resonant-cavity enhanced OHE, and in situ OHE experiments are discussed. Examples include silicon and sapphire optical constants, free charge carrier properties of two-dimensional electron gas in a group III nitride high electron mobility transistor structure, and ambient effects on free electron mobility and density in epitaxial graphene.

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  • 231. Order onlineBuy this publication >>
    Bernhardsson, Susanne
    Linköping University, Department of Medical and Health Sciences, Division of Physiotherapy. Linköping University, Faculty of Medicine and Health Sciences.
    Advancing evidence-based practice in primary care physiotherapy: Guideline implementation, clinical practice, and patient preferences2015Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Research on physiotherapy treatment interventions has increased dramatically in the past 25 years and it is a challenge to transfer research findings into clinical practice, so that patients benefit from effective treatment. Development of clinical practice guidelines is a potentially useful strategy to implement research evidence into practice. However, the impact of guideline implementation in Swedish primary care physiotherapy is unknown. To achieve evidence-based practice (EBP), research evidence should be integrated with clinical expertise and patient preferences, but knowledge is limited about these factors in Swedish primary care physiotherapy.

    The overall aim of this thesis was to increase understanding of factors of importance for the implementation of EBP in Swedish primary care physiotherapy. Specific aims were: to translate and adapt a questionnaire for the measurement of EBP and guidelines; to investigate physiotherapists’ attitudes, knowledge and behaviour related to EBP and guidelines; to examine clinical practice patterns; to evaluate the effects of a tailored guideline implementation strategy; and to explore patients’ preferences for physiotherapy.

    The thesis comprises four studies (A-D), reported in five papers. In Study A, a questionnaire for the measurement of EBP and guidelines was translated, cross-culturally adapted, and tested for validity (n=10) and reliability (n=42). Study B was a cross-sectional study in which this questionnaire was used to survey primary care physiotherapists in the county council Region Västra Götaland (n=271). In Study C, a strategy for the implementation of guidelines was developed and evaluated, using the same questionnaire (n=271 at baseline, n=256 at follow-up), in a prospective controlled trial. The strategy was based on an implementation model, was tailored to address the determinants of guideline use identified in Study B, and comprised several components including an educational seminar. Study D was an exploratory qualitative study of patients with musculoskeletal disorders (n=20), using qualitative content analysis.

    The validity and reliability of the questionnaire was found to be satisfactory. Most physiotherapists have a positive regard for EBP and guidelines, although these attitudes are not fully reflected in the reported use of guidelines. The most important determinants of  guideline use were considering guidelines important to facilitate practice and knowing how to integrate patient preferences with guidelines. The tailored, multi-component guideline implementation significantly affected awareness of, knowledge of, and access to guidelines. Use of guidelines was significantly affected among those who attended an implementation seminar. Clinical practice for common musculoskeletal conditions included interventions supported by evidence of various strengths as well as interventions with insufficient research evidence. The most frequently reported interventions were advice and exercise therapy. The interviewed patients expressed trust and confidence in the professionalism of physiotherapists and in the therapists’ ability to choose appropriate treatment, rendering treatment preferences subordinate. This trust seemed to foster active engagement in their physiotherapy.

    In conclusion: The adapted questionnaire can be used to reliably measure EBP in physiotherapy. The positive attitudes found do not necessarily translate to guideline use, due to several perceived barriers. The tailored guideline implementation strategy used can be effective to reduce barriers and contribute to increased use of guidelines. The clinical practice patterns identified suggest that physiotherapists rely both on research evidence and their clinical expertise when choosing treatment methods. Patients’ trust in their physiotherapist’s competence and preference for active engagement in their therapy need to be embraced by the clinician and, together with the therapist’s clinical expertise, integrated with guideline use in the clinical decision making. Further research is needed on how the EBP components and different knowledge sources can be integrated in physiotherapy practice, as well as on implementation effects on patient outcomes.

    List of papers
    1. Measuring Evidence-Based Practice in Physical Therapy: Translation, Adaptation, Further Development, Validation, and Reliability Test of a Questionnaire
    Open this publication in new window or tab >>Measuring Evidence-Based Practice in Physical Therapy: Translation, Adaptation, Further Development, Validation, and Reliability Test of a Questionnaire
    2013 (English)In: Physical Therapy, ISSN 0031-9023, E-ISSN 1538-6724, Vol. 93, no 6, p. 819-832Article in journal (Refereed) Published
    Abstract [en]

    Background. Evidence-based practice (EBP) and evidence-based clinical practice guidelines are becoming increasingly important in physical therapy. For the purpose of meeting the goals of designing, implementing, and evaluating strategies to facilitate the development of more EBP in primary care physical therapy, a valid and reliable questionnaire for measuring attitudes, knowledge, behavior, prerequisites, and barriers related to EBP and guidelines is needed. less thanbrgreater than less thanbrgreater thanObjective. The 3 objectives of this study were: (1) to translate and cross-culturally adapt a questionnaire to a Swedish primary care context for the purpose of measuring various aspects of EBP and guidelines in physical therapy, (2) to further develop the questionnaire to examine more aspects of guidelines, and (3) to test the validity and reliability of the adapted Swedish questionnaire. less thanbrgreater than less thanbrgreater thanDesign. This was an instrument development study with validity and reliability testing. less thanbrgreater than less thanbrgreater thanMethods. A previously used questionnaire about EBP was translated and cross-culturally adapted to a Swedish primary care physical therapy context. Additional items were constructed. A draft version was pilot tested for content validity (n=10), and a revised version was tested for test-retest reliability (n=42). The percentage of agreement between the 2 tests was analyzed. less thanbrgreater than less thanbrgreater thanResults. The development process resulted in a first questionnaire draft containing 48 items. The validation process resulted in a second draft with acceptable content validity and consisting of 38 items. The test-retest analysis showed that the median percentage of agreement was 67% (range=41%-81%). After removal or revision of items with poor agreement, the final questionnaire included 31 items. less thanbrgreater than less thanbrgreater thanLimitations. Only face validity and content validity were tested. less thanbrgreater than less thanbrgreater thanConclusions. The final translated and adapted questionnaire was determined to have good face and content validity and acceptable reliability for measuring self-reported attitudes, knowledge, behavior, prerequisites, and barriers related to EBP and guidelines among physical therapists in primary care settings.

    Place, publisher, year, edition, pages
    American Physical Therapy Association (APTA), 2013
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-95503 (URN)10.2522/ptj.20120270 (DOI)000319546800010 ()
    Available from: 2013-07-05 Created: 2013-07-05 Last updated: 2017-12-06
    2. Determinants of Guideline Use in Primary Care Physical Therapy: A Cross-Sectional Survey of Attitudes, Knowledge, and Behavior
    Open this publication in new window or tab >>Determinants of Guideline Use in Primary Care Physical Therapy: A Cross-Sectional Survey of Attitudes, Knowledge, and Behavior
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    2014 (English)In: Physical Therapy, ISSN 0031-9023, E-ISSN 1538-6724, Vol. 94, no 3, p. 343-354Article in journal (Refereed) Published
    Abstract [en]

    Background. Understanding of attitudes, knowledge, and behavior related to evidence-based practice (ESP) and use of evidence-based clinical practice guidelines in primary care physical therapy is limited. Objectives. The objectives of this study were: (1) to investigate self-reported attitudes, knowledge, behavior, prerequisites, and barriers related to EBP and guideline use among physical therapists in primary care and (2) to explore associations of self-reported use of guidelines with these social cognitive factors along with demographic and workplace characteristics. Design. This was a cross-sectional survey. Methods. A web-based survey of 419 physical therapists in primary care in western Sweden was performed. Multiple logistic regression analysis was performed to examine factors associated with guideline use. Results. The response rate was 64.7%. Most respondents had positive attitudes toward EBP and guidelines: 90% considered EBP necessary, and 96% considered guidelines important. Approximately two thirds reported confidence in finding and using evidence. One third reported being aware of guidelines. Thirteen percent knew where to find guidelines, and only 9% reported having easy access to guidelines. Fewer than half reported using guidelines frequently. The most important barriers to using guidelines were lack of time, poor availability, and limited access to guidelines. Young age and brief work experience were associated with positive attitudes toward EBP. A postgraduate degree was associated with higher application of EBP. Positive attitudes, awareness of guidelines, considering guidelines to facilitate practice, and knowing how to integrate patient preferences with guideline use were associated with frequent use of guidelines. Limitations. Data were self-reported, which may have increased the risk of social.desirability bias. Conclusions. Use of guidelines was not as frequent as could be expected in view of the positive attitudes toward EBP and guidelines among physical therapists. Awareness of and perceived access to guidelines were limited. The identified determinants can be addressed when developing guideline implementation strategies.

    Place, publisher, year, edition, pages
    American Physical Therapy Association (APTA), 2014
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-106033 (URN)10.2522/ptj.20130147 (DOI)000332351300008 ()
    Available from: 2014-04-17 Created: 2014-04-17 Last updated: 2023-12-28
    3. Evaluation of a tailored, multi-component intervention for implementation of evidence-based clinical practice guidelines in primary care physical therapy: a non-randomized controlled trial.
    Open this publication in new window or tab >>Evaluation of a tailored, multi-component intervention for implementation of evidence-based clinical practice guidelines in primary care physical therapy: a non-randomized controlled trial.
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    2014 (English)In: BMC Health Services Research, E-ISSN 1472-6963, Vol. 14, no 1, p. 105-Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND:

    Clinical practice guidelines are important for transmitting research findings into practice and facilitating the application of evidence-based practice (EBP). There is a paucity of knowledge about the impact of guideline implementation strategies in primary care physical therapy. The aim of this study was to evaluate the effect of a guideline implementation intervention in primary care physical therapy in western Sweden.

    METHODS:

    An implementation strategy based on theory and current evidence was developed. A tailored, multi-component implementation intervention, addressing earlier identified determinants, was carried out in three areas comprising 28 physical therapy practices including 277 physical therapists (PTs) (intervention group). In two adjacent areas, 171 PTs at 32 practices received no intervention (control group). The core component of the intervention was an implementation seminar with group discussions. Among other components were a website and email reminders. Data were collected at baseline and follow-up with a web-based questionnaire. Primary outcomes were the self-reported awareness of, knowledge of, access to, and use of guidelines. Secondary outcomes were self-reported attitudes toward EBP and guidelines. Analyses were performed using Pearson's χ2 test and approximative z-test.

    RESULTS:

    168 PTs (60.6%) in the intervention group and 88 PTs (51.5%) in the control group responded to the follow-up questionnaire. 186/277 PTs (67.1%) participated in the implementation seminars, of which 97 (52.2%) responded. The proportions of PTs reporting awareness of (absolute difference in change 20.6%, p = 0.023), knowledge where to find (20.4%, p = 0.007), access to (21.7%, p < 0.001), and frequent use of (9.5%, NS) guidelines increased more in the intervention group than in the control group. The proportion of PTs reporting frequent guideline use after participation in the implementation seminar was 15.2% (p = 0.043) higher than the proportion in the control group. A higher proportion considered EBP helpful in decision making (p = 0.018). There were no other significant differences in secondary outcomes.

    CONCLUSIONS:

    A tailored, theory- and evidence-informed, multi-component intervention for the implementation of clinical practice guidelines had a modest, positive effect on awareness of, knowledge of, access to, and use of guidelines, among PTs in primary care in western Sweden. In general, attitudes to EBP and guidelines were not affected.

    Place, publisher, year, edition, pages
    BioMed Central, 2014
    Keywords
    Implementation; Physical therapy; Evidence-based practice; Practice guidelines
    National Category
    Physiotherapy
    Identifiers
    urn:nbn:se:liu:diva-105610 (URN)10.1186/1472-6963-14-105 (DOI)000333535400002 ()24589291 (PubMedID)
    Available from: 2014-03-28 Created: 2014-03-28 Last updated: 2023-12-28
    4. Clinical practice in line with evidence?: A survey among primary care physiotherapists in western Sweden
    Open this publication in new window or tab >>Clinical practice in line with evidence?: A survey among primary care physiotherapists in western Sweden
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    2015 (English)In: Journal of Evaluation In Clinical Practice, ISSN 1356-1294, E-ISSN 1365-2753, Vol. 21, no 6, p. 1169-1177Article in journal (Refereed) Published
    Abstract [en]

    Rationale, aims and objectives

    Evidence-based practice is becoming increasingly important in primary care physiotherapy. Clinical practice needs to reflect current best evidence and be concordant with evidence-based clinical guidelines. There is limited knowledge about therapeutic interventions used in primary care physiotherapy in Sweden. The objectives were to examine preferred treatment interventions reported by publicly employed physiotherapists in primary care for three common musculoskeletal disorders (low back pain, neck pain and subacromial pain), the extent to which these interventions were supported by evidence, and associations with demographic variables.

    Methods

    419 physiotherapists in primary care in western Sweden were surveyed using a validated web-based questionnaire.

    Results

    The survey was completed by 271 respondents (65%). Median number of interventions reported was 7 (range 1–16). The most common treatment interventions across the three conditions were advice on posture (reported by 82–94%), advice to stay active (86–92%), and different types of exercise (65–92%). Most of these interventions were supported by evidence. However, interventions with insufficient evidence, such as advice on posture, TENS and aquatic exercise, were also used by 29–96%. Modalities such as laser therapy and ultrasound were sparingly used (<5%), which is in line with evidence. For neck pain, use of evidence-based interventions was associated with gender and for subacromial pain, with work experience.

    Conclusions

    Advice and exercise therapy were the interventions most frequently reported across the three diagnoses, illustrating an active treatment strategy. While most reported interventions are supported by evidence, interventions with unclear or no evidence of effect were also used to a high extent.

    Place, publisher, year, edition, pages
    John Wiley & Sons, 2015
    Keywords
    clinical practice, evidence, evidence-based practice, interventions, physical therapy, treatment
    National Category
    Health Care Service and Management, Health Policy and Services and Health Economy General Practice
    Identifiers
    urn:nbn:se:liu:diva-122555 (URN)10.1111/jep.12380 (DOI)000371414500032 ()25988993 (PubMedID)
    Note

    Funding agencies: local Research and Development Board for Gothenburg and Sodra Bohuslan; Linkoping University

    Available from: 2015-11-09 Created: 2015-11-09 Last updated: 2023-12-28Bibliographically approved
    5. “In the physio we trust”: A qualitative study on patients’ preferences for physiotherapy
    Open this publication in new window or tab >>“In the physio we trust”: A qualitative study on patients’ preferences for physiotherapy
    2017 (English)In: Physiotherapy Theory and Practice, ISSN 0959-3985, E-ISSN 1532-5040, Vol. 33, no 7, p. 535-549Article in journal (Refereed) Published
    Abstract [en]

    Background: Patient preferences are suggested to be incorporated in clinical decision making, but little is known about preferences for physiotherapy treatment of patients with musculoskeletal pain. This study aimed to explore preferences regarding physiotherapy treatment and participation in decision making, of patients who seek primary care physiotherapy for pain in the back, neck or shoulder.

    Methods: A qualitative study set in an urban physiotherapy clinic in Sweden. Individual, semi-structured interviews were conducted with a purposeful sample of 20 individuals who sought physiotherapy for back, neck or shoulder pain. The interviews were digitally recorded, transcribed verbatim and analysed with qualitative content analysis.

    Results: An overarching theme, embracing six categories, was conceptualised: Trust in the physiotherapist fosters active engagement in therapy. Most informants preferred active treatment strategies such as exercise and advice for self-management, allowing them to actively engage in their therapy. Some preferred passive treatments, primarily acupuncture (because they had heard that it works well) or massage therapy (because “it feels good”). Preferences were consistent across the three musculoskeletal conditions. Key influencers on treatment preferences were previous experiences and media. All informants wanted to be involved in the clinical decision making, but to varying extents. Some expressed a preference for an active role and wanting to share decisions while others were content with a passive role. Expectations for a professional management were reflected in trust and confidence in physiotherapists’ skills and competence, expectations for good outcomes, and believing that treatment methods should be evidence-based.

    Conclusions: Trust in the physiotherapist’s ability to choose appropriate treatment and confidence in the professional skills and competence of physiotherapists, as well as a desire to participate in clinical decision making, fostered active engagement in physiotherapy. Preferences for particular interventions were subordinate, although a preference for active treatments dominated. Preferences for active engagement need to be embraced by the physiotherapist. Awareness of these preferences can facilitate clinical decision making and contribute to increased quality of care for patients with musculoskeletal pain.

    Place, publisher, year, edition, pages
    Taylor & Francis, 2017
    Keywords
    Physical therapy, patient preferences, shared decision making, primary care, guidelines
    National Category
    Physiotherapy Public Health, Global Health, Social Medicine and Epidemiology
    Identifiers
    urn:nbn:se:liu:diva-122556 (URN)10.1080/09593985.2017.1328720 (DOI)000403937700003 ()
    Note

    Funding agencies: Local Research and Development Board for Gothenburg; Local Research and Development Board for Sodra Bohuslan

    Previous status of this publication was Manuscript

    Available from: 2015-11-09 Created: 2015-11-09 Last updated: 2023-12-28Bibliographically approved
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  • 232.
    Nilsson, Barbro
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences and Learning, Learning in Working Life and Educational Settings. Linköping University, Department of Behavioural Sciences and Learning, Work and Working Life. Linköping University, HELIX Vinn Excellence Centre.
    Advisory Partnership in a Governmental Mandated Network2008In: Partnership - as a Strategy for Social Innovation and Sustainable Change / [ed] Lennart Svensson & Barbro Nilsson, Stockholm: Santérus Academic Press , 2008, 1, p. 55-80Chapter in book (Other academic)
    Abstract [en]

    Is partnership as an organisational principle a way to overcome the limitations of project-organisation and its focus on short-term outcomes? Or is the interest in partnership organisations only an expression of a trend or a fashion in the growing market for organisational development in complex situations? In this book 14 scholars get new data and make careful analysis of the partnership organisation both in theory and in practice. They analyse the effectiveness of the partnership organisation in implementing changes and innovation with long-term effects rather than short-term results. The ambition is to address practical dilemmas and problems in the partnership organisation by using different theoretical perspectives - theories about organisational learning, strategies for change, power and empowerment, gender analysis, governance and participation etc. The research presented is valuable in order to achieve deeper understanding of the pros and cons with the partnership organisation. When can it be useful? What kind of problems can be addressed? Which conditions are necessary if the partnership model is to be used? Editors are Lennart Svensson, professor of sociology at the University of Linkoping, Sweden and Barbro Nilsson, Ph.D. and lecturer of pedagogic at the Institution of Behaviour Science learning at the University of Linkoping. Also contributing are Ken Caplan, Leda Stott, Erik Lindhult, Ingela Malqvist, Marianne Parmsund, Ann-Christine Larsson, Maria Bogren, Sofia Wistus, Ragnar Andersson, Hanna Westberg, Anette Scoppetta and Gun Hedlund.

  • 233.
    Cederlund, Veronica
    et al.
    Linköping University, The Tema Institute.
    Larsson, Helena
    Linköping University, The Tema Institute.
    Advocacy for Effective Activism2006Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
    Abstract [en]

    The Movement Action Plan (MAP) was created by Bill Moyer (1933-2002), an experienced activist engaged in movements for civil rights, peace and the environment, as he believed activists need to become aware of the roles they and their organisations are playing in the larger social movement in order to become successful. MAP is a practical strategy and action-planning model as well as a “how-to-do it” analytical tool for evaluating and organising social movements. The aim of this study is to investigate if the success of the Swedish Society for Nature Conservation (SSNC) can be explained by the MAP model through a triangulation of methods; quantitative content analysis of the SSNC’s action plans and annual reports (2000-2005), as well as qualitative interviews with employees at the SSNC. Throughout the research materials and interviews, the organisation clearly demonstrates that they advocate as effective activists according to Moyer. The overall conclusion from this research is that Moyer’s tools to a great extent already is utilised, and that this could explain the SSNC’s success in transforming from a small group of educated elites into becoming a social movement.

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  • 234.
    Andersson, Torbjörn
    et al.
    Linköping University, Department of Management and Engineering, Machine Design. Linköping University, Faculty of Science & Engineering.
    Warell, Anders
    Lund University, Lund Sweden.
    Aesthetic Flexibility in the Management of Visual Product Branding2015In: Procedia Manufacturing, ISSN 2351-9789, Vol. 3, p. 2191-2198Article in journal (Refereed)
    Abstract [en]

    This paper will investigate the strategic design decision-making of an in-house designer in a company with a large product portfolio, with respect to how designers plan for future visual alterations of the product. In-house designers have to think strategically about the creation of recognition and differentiation through design because they influence the company’s overall strategies. Therefore, while balancing aesthetic and semiotic qualities of the product, designers have to consider current as well as future needs for recognition and product differentiation. The ability to do so is affected by cost and brand positioning strategy. An exploratory study was setup to investigate what design strategies could be found in an industrial design team employed by a company. The study exposed how in-house designers could strategically incorporate aesthetic flexibility in product parts in order to create opportunities for faster facelifts or redesigns. The importance of managing carry-over details in larger product portfolios was also discovered. To carry over parts from different products is an important way for a company to save money, development time and at the same time increase brand recognition through repetition. Carry-over can be an aid to enhance visual recognition, but it can also be a hindrance when the designer needs to create differencing design values. Most products have a lifespan before they need to be updated or redesigned, which depends on the competition in a product segment. This makes it extra important for designers to have an understanding of when to incorporate carry-over details and when not to. A model was created to describe how carry-over details, design cues and aesthetic flexibility could be managed in a product portfolio. The model is based on Rune Monö’s works and brand management literature, with an emphasis on the brand positioning framework of Point of Difference, Point of Parity and brand extension by Keller et al.

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  • 235.
    Kald, Magnus
    et al.
    Linköping University, Department of Computer and Information Science, EISLAB - Economic Information Systems. Linköping University, The Institute of Technology.
    Nilsson, Fredrik
    Linköping University, Department of Computer and Information Science, EISLAB - Economic Information Systems. Linköping University, The Institute of Technology.
    Affärsstrategier, prestationsmätningssystem och ekonomiska resultat: empiriska bevis2003Conference paper (Refereed)
  • 236.
    Dawi, E. A.
    et al.
    Ajman Univ, U Arab Emirates.
    Mustafa, Elfatih Mohammed
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    Padervand, M.
    Univ Maragheh, Iran.
    Ashames, A.
    Ajman Univ, U Arab Emirates.
    Hajiahmadi, S.
    Shahid Beheshti Univ Med Sci, Iran.
    Saleem, L.
    Univ Amsterdam, Netherlands.
    Baghernejad, M.
    Forschungszentrum Julich GmbH, Germany.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    Ag/AgCl Decorated Ionic Liquid@Tantalum Pentoxide Nanostructures: Fabrication, Photocatalytic Activity, and Cytotoxicity Effects Against Human Brain Tumor Cells2023In: JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, ISSN 1574-1443Article in journal (Refereed)
    Abstract [en]

    Environmental contaminants have become a major concern for human beings due to their adverse effects on drinking water quality. Heterogeneous photocatalysis has been extensively investigated as a potential strategy to minimize the consequences of as-related processes. Using a room-temperature ionic liquid-mediated co-precipitation method, Ag@AgCl nanoparticles were loaded onto tantalum pentoxide to make a plasmonic photocatalyst to remove Congo Red dye. The physicochemical properties of the photocatalysts were characterized by X-ray diffraction powder (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), Diffuse Reflectance Spectroscopy (DRS), Fourier-transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM), photoluminescence (PL), and nitrogen adsorption-desorption isotherms. The results indicate that 96% of the dye was degraded within 20 min with a rate constant of 0.14 min(-1). The key radicals involved in the photocatalysis, recognized as O-2(center dot-) species, were identified by electron spin resonance (ESR) in the presence of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), as the spin trapping agent. Our findings and quenching experiments elucidates the mechanism of the charge carrier migration. The cytotoxicity activity of the nanostructures was also examined against human brain glioblastoma tumor cells for the first time. A precise analysis of the cell death pathway was conducted using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and caspase activity assays in combination with fluorescence microscopy images. The prepared nanomaterials were found to be promising candidates for treating the organic pollutants and biomedical waste effluents from academic and industrial activities.

  • 237.
    Keresztes, Réka
    Linköping University, Department of Culture and Communication.
    Against the Odds: The challenges of bilingualism in a monolingual environment2006Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this study has been to describe the reasoning of five immigrant parents with Swedish partners who raise their child to become bilingual. Having interviewed the informants, three central themes became apparent: bilingualism, identity and the environment. All five families reason that they raise their child with the mother tongue of the mother and the mother tongue of the father and that it is natural. Discussions about identity and culture are made in specific reference to the surrounding monolingual environment, which is often perceived as an obstacle to bilingualism.

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  • 238.
    Damman, Peter
    et al.
    University of Amsterdam.
    Clayton, Tim
    London School Hyg and Trop Med.
    Wallentin, Lars
    University of Amsterdam.
    Lagerqvist, Bo
    UCR, Uppsala.
    Fox, Keith A
    Royal Infirm, Edinburgh.
    Hirsch, Alexander
    University of Amsterdam.
    Windhausen, Fons
    University of Amsterdam.
    Swahn, Eva
    Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.
    Pocock, Stuart J
    London School Hyg and Trop Med.
    Tijssen, Jan G
    University of Amsterdam.
    de Winter, Robbert J
    University of Amsterdam.
    Age and 5-Year Outcomes After a Routine or Selective Invasive Strategy for Non-ST-Segment Elevation Acute Coronary Syndromes in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol 58, issue 20, pp B110-B1102011In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Elsevier , 2011, Vol. 58, no 20, p. B110-B110Conference paper (Refereed)
    Abstract [en]

    n/a

  • 239.
    Börjesson, Maria
    et al.
    VTI Swedish Road and Transport Research Institute, Stockholm, Sweden; KTH Royal Institute of Technology, Stockholm, Sweden.
    Isacsson, Gunnar
    Swedish Transport Administration, Borlänge, Sweden.
    Andersson, Mats
    WSP Analysis & Strategy, Stockholm, Sweden.
    Anderstig, Christer
    WSP Analysis & Strategy, Stockholm, Sweden.
    Agglomeration, productivity and the role of transport system improvements2019In: Economics of Transportation, ISSN 2212-0122, E-ISSN 2212-0130, Vol. 18, p. 27-39Article in journal (Refereed)
    Abstract [en]

    We explore how transport improvements impact agglomeration defined as accessibility and thereby productivity in mid-Sweden including Stockholm 1995–2006. We apply an accessibility index derived from a multi-modal transport model. This is a more accurate measure of agglomeration than those previously used and also necessary for understanding how governments can impact agglomeration, and thereby productivity, by transport investments. We regress temporal changes in wages on temporal changes in agglomeration by applying a FE estimator. We deal with the potential endogeneity using a novel instrumental variable. Our best estimates of the agglomeration elasticity on productivity lie within the interval 0.028–0.035.

  • 240.
    Khodaparast, Ladan
    et al.
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Khodaparast, Laleh
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Gallardo, Rodrigo
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Louros, Nikolaos N.
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Michiels, Emiel
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Ramakrishnan, Reshmi
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Ramakers, Meine
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Claes, Filip
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Young, Lydia
    Univ Leeds, England; Univ Leeds, England.
    Shahrooei, Mohammad
    KULeuven, Belgium.
    Wilkinson, Hannah
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Desager, Matyas
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Tadesse, Wubishet Mengistu
    KULeuven, Belgium.
    Nilsson, Peter
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Hammarström, Per
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Aertsen, Abram
    KULeuven, Belgium.
    Carpentier, Sebastien
    KULeuven, Belgium.
    Van Eldere, Johan
    KULeuven, Belgium.
    Rousseau, Frederic
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Schymkowitz, Joost
    SWITCH Lab, Belgium; KULeuven, Belgium.
    Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis2018In: Nature Communications, E-ISSN 2041-1723, Vol. 9, article id 866Article in journal (Refereed)
    Abstract [en]

    Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are unique within a proteome, but that a small minority of APRs occur in many proteins. When aggregation is nucleated in bacteria by such frequently occurring APRs, it leads to massive and lethal inclusion body formation containing a large number of proteins. Buildup of bacterial resistance against these peptides is slow. In addition, the approach is effective against drug-resistant clinical isolates of Escherichia coli and Acinetobacter baumannii, reducing bacterial load in a murine bladder infection model. Our results indicate that redundant APRs are weak points of bacterial protein homeostasis and that targeting these may be an attractive antibacterial strategy.

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  • 241.
    Eriksson, Mia
    et al.
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Peña-Martínez, Pablo
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Ramakrishnan, Ramprasad
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Chapellier, Marion
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Högberg, Carl
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Glowacki, Gabriella
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Orsmark-Pietras, Christina
    Department of Clinical Genetics, Lund University, Lund, Sweden.
    Velasco-Hernández, Talía
    Department of Molecular Hematology, Lund University, Lund, Sweden.
    Lazarevic, Vladimir Lj
    Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
    Juliusson, Gunnar
    Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
    Cammenga, Jörg
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology.
    Mulloy, James C
    Division of Experimental Hematology and Cancer Biology, Cincinnati Childrens Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
    Richter, Johan
    Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
    Fioretos, Thoas
    Department of Clinical Genetics, Lund, Sweden.
    Ebert, Benjamin L.
    Division of Hematology, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, USA.
    Järås, Marcus
    Department of Clinical Genetics, Lund, Sweden.
    Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NF?B-dependent differentiation of AML cells2017In: Blood Advances, ISSN 2473-9529 , E-ISSN 2473-9537, Vol. 1, no 23, p. 2046-2057Article in journal (Refereed)
    Abstract [en]

    Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregulated on primary AML CD34+CD38-cells relative to corresponding normal bone marrow cells. Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 inMLL-AF9-driven human AML resulted in induction of apoptosis by p38 MAPK-dependent activation of Caspase 3 and myeloid differentiation in a NF?B-dependent manner. By using murineTrp53 -/- MLL-AF9AML cells, we demonstrate that p53 is dispensable for Pam3CSK4-induced apoptosis and differentiation. Moreover, murineAML1-ETO9a-driven AML cells also were forced into apoptosis and differentiation on TLR1/TLR2 activation, demonstrating that the antileukemic effects observed were not confined toMLL-rearranged AML. We further evaluated whether Pam3CSK4 would exhibit selective antileukemic effects. Ex vivo Pam3CSK4 treatment inhibited murine and human leukemia-initiating cells, whereas murine normal hematopoietic stem and progenitor cells (HSPCs) were relatively less affected. Consistent with these findings, primary human AML cells across several genetic subtypes of AML were more vulnerable for TLR1/TLR2 activation relative to normal human HSPCs. In theMLL-AF9AML mouse model, treatment with Pam3CSK4 provided proof of concept for in vivo therapeutic efficacy. Our results demonstrate that TLR1 and TLR2 are upregulated on primitive AML cells and that agonistic targeting of TLR1/TLR2 forces AML cells into apoptosis by p38 MAPK-dependent activation of Caspase 3, and differentiation by activating NF?B, thus revealing a new putative strategy for therapeutically targeting AML cells.

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  • 242.
    Duchamp, Vincent
    et al.
    ENAC.
    Josefsson, Billy
    LFV.
    Polishchuk, Tatiana
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Polishchuk, Valentin
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Sáez, Raul
    UPC Barcelona.
    Wiren, Richard
    Ericsson, Finland.
    Air Traffic Deconflicon Using Sum Coloring2019Conference paper (Refereed)
    Abstract [en]

    This paper studies strategic conflict resolution for air traffic based on sum coloring. We consider two application scenarios: manned and unmanned air traffic, with similar targets: to improve efficiency of operations and to reduce the costs. For the Unmanned Air Vehicles Traffic Management (UTM) we consider also a payment mechanism which incentivizes the operators to share information necessary to find a socially optimal solution. We quantify the potential savings via a series of experiments, showing that our methods drastically outperform the widely used FirstCome-First-Serve (FCFS) strategy.

  • 243.
    Duchamp, Vincent
    et al.
    Ecole Natl Aviat Civile ENAC, France.
    Josefsson, Billy
    LFV, Sweden.
    Polishchuk, Tatiana
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Polishchuk, Valentin
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Saez, Raul
    Tech Univ Catalonia UPC, Spain.
    Wiren, Richard
    Ericsson, Finland.
    Air Traffic Deconfliction Using Sum Coloring2019In: 2019 IEEE/AIAA 38TH DIGITAL AVIONICS SYSTEMS CONFERENCE (DASC), 2019Conference paper (Refereed)
    Abstract [en]

    This paper studies strategic conflict resolution for air traffic based on sum coloring. We consider two application scenarios: manned and unmanned air traffic, with similar targets: to improve efficiency of operations and to reduce the costs. For the Unmanned Air Vehicles Traffic Management (UTM) we consider also a payment mechanism which incentivizes the operators to share information necessary to find a socially optimal solution. We quantify the potential savings via a series of experiments, showing that our methods drastically outperform the widely used First-Come -First-Serve (FCFS) strategy.

  • 244.
    Hadziefendic, Adnan
    et al.
    Linköping University, Department of Management and Engineering, Business Administration .
    Emborg, Oscar
    Linköping University, Department of Management and Engineering, Business Administration .
    Aktieanalytikers rekommendationer:värdet av revideringar på de nordiska marknaderna2010Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: To determine whether or not stock analysts as a group add value for investors the question that should be asked is if it’s profitable to follow the analysts' consensus recommendations. A problem with following these is that the recommendations that enter into the consensus can remain unchanged for long periods which mean that they generally become less informative over time. Studies that instead evaluate recommendation revisions have shown that it can be more profitable to follow the analysts when they change their opinions regarding a stock.

    Aim: The aim of this study is to evaluate analysts’ recommendation revisions in the Nordic markets and to analyze investment strategies based on these revisions that consider the impact of transaction costs.

    Completion: The recommendation revisions have been evaluated quantitatively using data from Inquiry Financial for the period 2006 – 2009. We construct six portfolios for each market, where the portfolios consist of up- and downgraded stocks with different holding periods in order to determine how informative the revisions are.

    Findings: We find that recommendation revisions are informative in several of the studied markets, where stock prices continue to drift upward for upgrades and downward for downgrades several months after the revision. An investor acting on these revisions would have been able to generate abnormal returns in a number of considered strategies, gross of transaction costs. When the impact of transaction costs is considered no strategy generates significant alpha due to the frequent rebalancing required, but the results nonetheless indicates that there is value in following the revisions.

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  • 245.
    Besterman, Andreas
    et al.
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Larsson, Mattias
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Aktieavkastningars relation till fundamental multiplar: En studie om fundamentala värdedrivare och prisanomalier på marknaden2016Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Previous studies has presented evidence of abnormal stock returns when applying valuemultiple based strategies in assembling portfolios. The previous studies has not consideredthe fundamental theoretical values that determine the value multiple. As a consequence, it isof interest to examine the performance of portfolios assembled with respect to thesefundamental value drivers. With the use of regression analysis, it is of interest to find out ifportfolios can be constructed that outperform the market portfolio in a sense of risk adjustedreturns.

    Purpose: This study aims to empirically examine if future stock returns can be derived from therelationship between their fundamentally determined multiples and the market multiple.

    Implementation: With the help of regression analysis of value multiples this study derives their equilibriumprice of stocks and apply deviation from equilibrium in construction of portfolios.

    Conclusion: The results indicate that a strategy based on regressions of the EV/EBITDA multiple maygenerate superior risk adjusted portfolio returns than suggested by the efficient markethypothesis during the period between 2006-2016. Similar results was found using the P/Emultiple however these results could not be statistically confirmed. Using the EV/S multipleno risk adjusted abnormal returns could be proven.

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  • 246.
    Gilani, Göransson, Adrian
    et al.
    Linköping University, Department of Management and Engineering. Linköping University, Faculty of Arts and Sciences.
    Nizialek, Dawid
    Linköping University, Department of Management and Engineering. Linköping University, Faculty of Arts and Sciences.
    Aktiers avkastning i relation till EV/Sales, EV/EBITDA och P/B: En kvantitativ studie om investeringsstrategier på Nasdaq First North mellan 2010-20212021Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: With an increasing interest in the stock market, more people are searching for simple tips and tricks in order to achieve what all investors strive for, beating the market. Several investment strategies have been studied on different markets and over different time periods, however few of these on Nasdaq First North. Previous studies have mainly focused on larger stock markets such as the NYSE or FTSE, whilst Swedish studies tend to analyse Nasdaq Stockholm. As a result, there is room for examining whether an investment strategy can be constructed which can beat Nasdaq First North over time. The strategies which are analysed are based on the multiples deemed most suitable for the relatively young and small companies listed on First North.

    Purpose: The study aims to analyse whether investment strategies based on the valuation multiples EV/Sales, EV/EBITDA and P/B can be exploited to generate excess returns in both absolute and risk adjusted terms against the benchmark index First North All-Share, which is comprised of all stocks listed on the stock market First North. 

    Method: The study applies a quantitative research approach. Data for all companies listed on First North over the time period 2010-2021 have been collected in order to create low and high valued portfolios for each multiple. These have in turn been evaluated based on yearly and accumulated returns as well as risk adjusted measures such as their Jensens alpha, Treynor index and Sharpe ratio. 

    Results: Five of six portfolios generated excess accumulated returns against the benchmark index and all six generated excess risk adjusted returns against the benchmark index over the eleven-year time period. The highest absolute return was generated by the low EV/Sales portfolio and the lowest absolute return was generated by the high P/B portfolio.

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  • 247.
    Adem Nur, Bellal
    et al.
    Linköping University, Department of Management and Engineering, Economics. Linköping University, Faculty of Arts and Sciences.
    Huskanovic, Jasmin
    Linköping University, Department of Management and Engineering, Economics. Linköping University, Faculty of Arts and Sciences.
    Aktiv eller passiv, vilken förvaltningsstrategi har presterat bäst under coronapandemin?: - En komparativ studie baserad på svenska fonder2022Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis examines whether active or passive fund management has performed better during the corona pandemic in the Swedish fund market. With the help of Refinitiv Eikon and Morningstar, we have collected relevant weekly data for 20 actively managed funds and 12 passively managed funds between 2020-03-06 and 2022-02-11. After careful calculation of the various performance measures in Microsoft Excel, we can state that the passive management has performed better during the corona pandemic, but this result is not a guarantee for future fund choices during future crises or economic shocks.

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  • 248.
    Lindström, Veronica
    et al.
    Linköping University, Department of Management and Engineering, Production Economics . Linköping University, The Institute of Technology.
    Winroth, Mats
    Chalmers University.
    Aligning manufacturing strategy and levels of automation: A Case Study2010In: Journal of engineering and technology management, ISSN 0923-4748, E-ISSN 1879-1719, Vol. 27, no 3-4, p. 148-159Article in journal (Refereed)
    Abstract [en]

    Research has shown that alignment between manufacturing strategy and decisions regarding automation are often of an ad hoc nature, i.e. the support for automation decisions is poor. Support tools to find an appropriate level of automation are thus needed in order to achieve more efficient and robust production systems. The methodology presented in this paper contains five sub-processes where the chosen level of automation is aligned with the manufacturing strategy. Together they form an automation strategy, which secures a desired direction of the firm and also supports robustness and reliability of the manufacturing system due to the holistic approach chosen.

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  • 249.
    Kurilova-Palisaitiene, Jelena
    et al.
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering.
    Sundin, Erik
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Department of Management and Engineering, Environmental Technology and Management.
    Aligning remanufacturing in comparison to recirculation processes2021Conference paper (Refereed)
    Abstract [en]

    Remanufacturing is a value retention process (VRP), along with direct reuse, repair, and comprehensive refurbishment, which prepares the used product for new uses by controlling and recapturing its value through several industrial operations. Remanufacturing possesses significant financial, environmental, and societal opportunities, and some manufacturers tend to challenge their business models, production systems, products, logistics, and customer management to comply with a circular economy (CE). 

    However, remanufacturing is sometimes undervalued and is ranked low, compared to other VRPs, among the recirculation processes (after-use-phase processes that bring and keep used products, their parts or material in a closed material loop through reuse, recycling, downcycling, and upcycling). The main reason for this is the greater number of resources required and fewer benefits provided compared to direct product reuse and repair. This paper studies a remanufacturer using different VRPs to satisfy customer needs and to better balance an incoming core (used product and its part) quality and the demanded product quality. 

    The aim of this paper is to define remanufacturing value and better align remanufacturing in comparison to other recirculation processes. The data was collected through a literature study and interviews with an EEE remanufacturer to fulfill the aim of this paper. The literature study covered the previous knowledge on remanufacturing, VRPs and recirculation processes. The interviews with an EEE remanufacturer provided valuable input to the scope of the VRPs performed by a single remanufacturer.

    Lean approaches the remanufacturing value from a customer perspective shifting the paradigm of VRP, where remanufacturing is ranked low. Remanufacturing tends to demand greater resources to save the product value and implies greater product intervention. However, the output quality assured with a longer warranty, new product identity and prolonged (doubled or tripled) product use phase overcomes the benefits associated with the other VRPs, when customer value is in focus. The analysis of the remanufacturing value in comparison to other recirculation processes elevates remanufacturing in a recirculation taxonomy for technical products. The assessment of social, environmental, and economic benefits with remanufacturing compliments the findings. The result of the study lays the foundation for the development of the “9R taxonomy” – a framework on recirculation processes for technical products, where six VRPs can be handled by a remanufacturer.

  • 250.
    López Romero, Ana-María
    Linköping University, Department of Thematic Studies, Tema Environmental Change.
    Alignment of mitigation pledges with government expenditure in Latin America: A case study of Chile, Colombia and Peru in the COVID-19 context2021Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The implementation of Nationally Determined Contributions (NDC) in 2020 has coincided with the outbreak of COVID-19. Recovery paths taken to deal with the economic consequences of the pandemic can be either an opportunity to foster a sustainable growth or a return to business-as-usual model. Assuming that national budgets define the economic strategy of governments, this thesis addresses the relationship between mitigation pledges outlined in NDCs and mitigation-related expenditure in Chile, Peru and Colombia pre- and during the COVID-19 pandemic. A deductive thematic analysis of NDCs is used to identify the prioritized mitigation sectors and to allow for a refined focus in the analysis of the relevant mitigation-related expenses for each case country. Budgets of 2020 and 2021 are compared and discussed in the light of previous research. Results show different levels of climate ambition but common prioritised sectors (energy, land-use, and industry). Regarding Peru, the budgets indicate a higher mitigation ambition than their NDC by including expenditure in areas that are not mentioned in the NDC. Contrary, Colombia and Chile have detailed NDCs that cover more aspects than indicated through their government expenditure. Generally, energy and industry expenditure misalign with the NDC pledges, due to the increase of expenses on national fossil fuels resources in 2021. Land-use mitigation expenditure, linked to forestry and agriculture, have increased in Chile and Peru but are hardly represented in Colombia. Thus, the thesis outlines early misalignments of mitigation targets with government expenditure and differences in accountability and transparency that could challenge the monitoring of progress towards the achievement of the pledges.

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